Updated on 2022/07/25

写真a

 
MATSUNAGA Shinji
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • 博士（医学） （ Tottori University ）

  • 修士（薬学） （ Gifu Pharmaceutical University ）

Research Areas

  • Life Science / Pharmacology

Research Interests

  • 腫瘍血管

  • 抗癌剤

  • 腫瘍

Research subject summary

  • 腫瘍血管と腫瘍組織環境

Research Career

  • 腫瘍組織環境と血管正常化

    2013.05 - Now 

  • DNA損傷修復におけるDNA二重鎖切断修復遺伝子変異の影響

    2011.07 - 2014.03 

  • 癌患者における細菌感染と腫瘍免疫

    2007.04 - 2011.07 

Professional Memberships

  • 日本薬理学会

      Domestic

  • 日本臨床薬理学会

      Domestic

  • 日本癌学会

      Domestic

  • 日本薬学会

      Domestic

Job Career (off-campus)

  • 鳥取大学医学部病態解析医学講座   分子薬理学分野   助教

    2013.05 - 2016.06

  • University of Texas Southwestern Medical Center   Department of Radiation Oncology   Post Doctoral Fellow

    2011.07 - 2013.04

  • 鳥取大学医学部附属病院　   薬剤部   薬剤師

    2010.07 - 2011.07

  • 独立行政法人国立病院機構　米子医療センター   薬剤科   薬剤師

    2006.04 - 2010.06

Education

  • Tottori University   Doctor's Course   Graduated/Completed

    2007.04 - 2011.03

  • Gifu Pharmaceutical University   The first semester of doctoral program   Graduated/Completed

    2004.04 - 2006.03

  • Gifu Pharmaceutical University     Graduated/Completed

    2000.04 - 2004.03

Papers

  • Prolyl-hydroxylase inhibitors reconstitute tumor blood vessels in mice(和訳中) Reviewed

    Nishide Shunji, Uchida Junji, Matsunaga Shinji, Tokudome Kentaro, Yamaguchi Takehiro, Kabei Kazuya, Moriya Taiki, Miura Katsuyuki, Nakatani Tatsuya, Tomita Shuhei

    (公社)日本薬理学会　Journal of Pharmacological Sciences   143 ( 2 )   122 - 126   2020.06（ ISSN:1347-8613 ）

  • Effects of orally active hypoxia inducible factor alpha prolyl hydroxylase inhibitor, FG4592 on renal fibrogenic potential in mouse unilateral ureteral obstruction model. Reviewed

    Kabei K, Tateishi Y, Shiota M, Osada-Oka M, Nishide S, Uchida J, Nakatani T, Matsunaga S, Yamaguchi T, Tomita S, Miura K

    Journal of pharmacological sciences   142 ( 3 )   93 - 100   2020.03（ ISSN:1347-8613 ）

    　More details

  • Controlling the Phenotype of Tumor-Infiltrating Macrophages via the PHD-HIF Axis Inhibits Tumor Growth in a Mouse Model. Reviewed

    Nishide S, Matsunaga S, Shiota M, Yamaguchi T, Kitajima S, Maekawa Y, Takeda N, Tomura M, Uchida J, Miura K, Nakatani T, Tomita S

    iScience   19   940 - 954   2019.09

    　More details

  • A dipeptidyl peptidase-4 (DPP-4) inhibitor, linagliptin, attenuates cardiac dysfunction after myocardial infarction independently of DPP-4. Reviewed

    Yamaguchi T, Watanabe A, Tanaka M, Shiota M, Osada-Oka M, Sano S, Yoshiyama M, Miura K, Kitajima S, Matsunaga S, Tomita S, Iwao H, Izumi Y

    Journal of pharmacological sciences   139 ( 2 )   112 - 119   2019.02（ ISSN:1347-8613 ）

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  • Tumour blood vessel normalisation by prolyl hydroxylase inhibitor repaired sensitivity to chemotherapy in a tumour mouse model Reviewed

    Koyama Satoshi, Matsunaga Shinji, Imanishi Masaki, Maekawa Yoichi, Kitano Hiroya, Takeuchi Hiromi, Tomita Shuhei

    SCIENTIFIC REPORTS   7   45621   2017.03（ ISSN:2045-2322 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep45621

    PubMed

  • Hypoxia-Inducible Factor-1 alpha in Smooth Muscle Cells Protects Against Aortic Aneurysms-Brief Report Reviewed

    Imanishi Masaki, Chiba Yoichi, Tomita Noriko, Matsunaga Shinji, Nakagawa Toshitaka, Ueno Masaki, Yamamoto Kazuhiro, Tamaki Toshiaki, Tomita Shuhei

    ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY   36 ( 11 )   2158 - +   2016.11（ ISSN:1079-5642 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1161/ATVBAHA.116.307784

    PubMed

  • Spontaneous tumor development in bone marrow-rescued DNA-PKcs(3A/3A) mice due to dysfunction of telomere leading strand deprotection Reviewed

    Zhang S., Matsunaga S., Lin Y-F, Sishc B., Shang Z., Sui J., Shih H-Y, Zhao Y., Foreman O., Story M. D., Chen D. J., Chen B. P. C.

    ONCOGENE   35 ( 30 )   3909 - 3918   2016.07（ ISSN:0950-9232 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/onc.2015.459

  • The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair. Reviewed

    Li M, Lin YF, Palchik GA, Matsunaga S, Wang D, Chen BP

    Free radical biology & medicine   76   278 - 85   2014.11（ ISSN:0891-5849 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.freeradbiomed.2014.08.019

    PubMed

  • DNA-PKcs is required to maintain stability of Chk1 and Claspin for optimal replication stress response. Reviewed

    Lin YF, Shih HY, Shang Z, Matsunaga S, Chen BP

    Nucleic acids research   42 ( 7 )   4463 - 73   2014.04（ ISSN:0305-1048 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/nar/gku116

    PubMed

  • DNA-PKcs activates the Chk2–Brca1 pathway during mitosis to ensure chromosomal stability. Reviewed

    3 ( 2 )   e85   2014

    　More details

    Publishing type：Research paper (scientific journal)  

  • Diagnostic and prognostic impact of serum-soluble UL16-binding protein 2 in lung cancer patients. Reviewed

    Yamaguchi K, Chikumi H, Shimizu A, Takata M, Kinoshita N, Hashimoto K, Nakamoto M, Matsunaga S, Kurai J, Miyake N, Matsumoto S, Watanabe M, Yamasaki A, Igishi T, Burioka N, Shimizu E

    Cancer science   103 ( 8 )   1405 - 13   2012.08（ ISSN:1347-9032 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    DOI： 10.1111/j.1349-7006.2012.02330.x

    PubMed

  • Pseudomonas aeruginosa quorum-sensing molecule N-3-oxo-dodecanoyl homoserine lactone down-regulate cell surface ULBP2 on lung cancer cell lines Reviewed

    62 ( 2 )   77 - 90   2011.03（ ISSN:00440558 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    CiNii Article

  • Incadronate induces cell detachment and apoptosis in prostatic PC-3 cells. Reviewed

    Matsunaga S, Iguchi K, Usui S, Hirano K

    Anticancer research   27 ( 2 )   927 - 32   2007.03（ ISSN:0250-7005 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    PubMed

  • Inhibition of caveolin-1 expression by incadronate in PC-3 prostate cells. Reviewed

    Iguchi K, Matsunaga S, Nakano T, Usui S, Hirano K

    Anticancer research   26 ( 4B )   2977 - 81   2006.07（ ISSN:0250-7005 ）

    　More details

    Publishing type：Research paper (scientific journal)  

    PubMed

  • Survey of the Use of Supplements by Persons Visiting Gifu Pharmaceutical University Pharmacy Reviewed

    ADACHI Tetsuo, MATSUNAGA Shinji, KUBOTA Masafumi, TAKASHIMA Eiji, TSUCHIYA Teruo, HIRANO Kazuyuki

    Japanese Society of Pharmaceutical Health Care and Sciences, Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)   31 ( 10 )   845 - 850   2005.10（ ISSN:1346342X ）

    　More details

    Publishing type：Research paper (scientific journal)  

    Amid the increasing use of supplements due to people's growing interest in their health and deregulation, there have been cases of supplements adversely affecting people's health and interacting with drugs. For this reason, pharmacists are often required to give guidance on the use of supplements.<BR>We conducted a questionnaire survey concerning the use of supplements by persons visiting the Gifu Pharmaceutical University Pharmacy, which had the following findings. Of those surveyed, 41.8% had used supplements. A large number of younger people used vitamin and mineral preparations for health maintenance and dieting purposes, and many older people used various supplements for health maintenance and as an additional treatment for diseases. Eighty-five percent of those surveyed said that they read the precautions for use, but only 55% checked warnings and adverse effects and just 59% said they were aware of interactions with drugs, indicating a lack of awareness of the risks of supplements. When pharmacists are consulted concerning the use of supplements, they should base their advice on knowledge of the patient's use of drugs and emphasize the need to improve their lifestyle so that they do not have to depend on supplements.

    DOI： 10.5649/jjphcs.31.845

    CiNii Article

▼display all

Presentations

Industrial Property Rights

  • 腫瘍関連マクロファージ賦活化剤

    冨田　修平、松永　慎司

    　More details

    property_type：Patent 

    Application no：特願2019-143014 

  • 抗癌剤の抗腫瘍効果の増強剤、癌治療剤、及び癌治療用医薬組成物

    冨田　修平、松永　慎司

    　More details

    property_type：Patent 

    Application no：2016-171299 

    Announcement no：特開2018-35112 

    Publication no：特開2018-35112 

Grant-in-Aid for Scientific Research

  • 腫瘍微小環境改善薬による抗腫瘍免疫応答制御機構の解明

    Grant-in-Aid for Scientific Research(C)  2020.04

  • 抗癌剤増感作用をもたらす腫瘍内血管再構築機構の解明

    Grant-in-Aid for Young Scientists(B)  2017.04

Outline of education staff

  • 薬理学

Charge of on-campus class subject

  • 医学研究基本演習

    2021     Graduate school

  • 生体と薬物

    2021     Undergraduate

  • 薬理学実習（生体と薬物）

    2021   Practical Training   Undergraduate

  • 修業実習

    2021     Undergraduate

  • 薬理学実習

    2020     Undergraduate

  • 修業実習

    2020     Undergraduate

  • 看護科薬理学

    2020     Undergraduate

  • 医学研究基本演習

    2020     Graduate school

  • 薬理学実習

    2019     Undergraduate

  • 看護科薬理学

    2019     Undergraduate

  • 医学研究基本演習

    2019     Graduate school

  • 修業実習

    2019     Undergraduate

  • 薬理学実習

    2018     Undergraduate

  • 医学研究基本演習

    2018     Graduate school

  • 看護科薬理学

    2018     Undergraduate

  • 修業実習

    2017     Undergraduate

  • 薬理学実習

    2017     Undergraduate

  • 看護科薬理学

    2017     Undergraduate

  • 医学研究基本演習

    2017     Graduate school

  • 薬理学実習

    2016     Undergraduate

▼display all

Charge of off-campus class subject

  • 薬理学

    Institution：Tottori University

Number of instructed thesis, researches

  • 2020

    [Number of instructed the Master's Program] (previous term)：1  [Number of instructed the Master's Program] (letter term)：1

Other

  • Job Career

    2016.07 - 2017.09