Updated on 2024/04/12

写真a

 
OINUMA Ken-Ichi
 
Organization
Graduate School of Medicine Department of Basic Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • Ph.D. in Agricultural Science （ University of Tsukuba ）

Research Areas

  • Life Science / Bacteriology

Research Interests

  • 緑膿菌

  • クオラムセンシング

  • 薬剤耐性

  • 感染症

  • 細菌

Research subject summary

  • 1) 日和見感染菌の細胞間コミュニケーションと病原性制御機構の解析
    2) 病原菌の薬剤耐性機構の解明

Professional Memberships

  • 日本バイオフィルム学会

      Domestic

  • 日本生化学会

      Domestic

  • 日本感染症学会

      Domestic

  • 緑膿菌感染症研究会

      Domestic

  • 日本農芸化学会

      Domestic

  • 日本医真菌学会

      Domestic

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Committee Memberships (off-campus)

  • 会員   日本バイオフィルム学会  

    2020.12 - Now 

  • 会員   日本医真菌学会  

    2016.08 - Now 

  • 会員   日本感染症学会  

    2016.06 - Now 

  • 会員   緑膿菌感染症研究会  

    2015.11 - Now 

  • 会員   糸状菌分子生物学研究会  

    2012.09 - 2023.06 

  • 会員   日本生化学会  

    2003.05 - Now 

  • 会員   日本農芸化学会  

    2001.11 - Now 

▼display all

Awards

  • 筑波大学学長表彰

    2006.03  

Job Career (off-campus)

  • 東京農業大学   生命科学研究科バイオサイエンス専攻   非常勤講師

    2021.11 - Now

  • 帝塚山大学   現代生活学部   非常勤講師

    2017.09 - Now

  • 筑波大学   生命環境系   助教

    2012.04 - 2015.03

  • 日本大学   生物資源科学部   ポストドクトラルフェロー

    2011.04 - 2012.03

  • University of Washington   Department of Microbiology

    2009.04 - 2011.03

  • University of Washington   Department of Microbiology

    2007.04 - 2009.03

  • 筑波大学大学院   生命環境科学研究科   日本学術振興会特別研究員（DC2, PD）

    2005.04 - 2007.03

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Education

  • Nihon University     Graduated/Completed

    1997.04 - 2001.03

Papers

  • Identification of a mycobacterial hydrazidase, an isoniazid-hydrolyzing enzyme. Reviewed

    Sakiyama A, Saren C, Kaneko Y, Oinuma K

    Scientific reports   13 ( 1 )   8180   2023.05

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-023-35213-5

    PubMed

  • Differences in severity of bacteraemia caused by hypermucoviscous and non-hypermucoviscous Klebsiella pneumoniae. Reviewed

    Hiroki Namikawa, Ken-Ichi Oinuma, Koichi Yamada, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto

    International journal of antimicrobial agents   61 ( 5 )   106767 - 106767   2023.05（ ISSN:0924-8579 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Klebsiella pneumoniae strains pose a significant threat to public health. Currently, it is inconclusive whether hypermucoviscous K. pneumoniae (hmKp; semi-quantitatively defined by a positive 'string test') bacteraemia is clinically more severe than non-hmKp bacteraemia. Hence, this systematic review and meta-analysis was conducted with the aim of drawing some conclusions on hypermucoviscosity and bacteraemia. METHODS: PubMed and Web of Science databases were searched for all relevant publications from January 2000 to March 2022. The outcome measures were mortality rate and abscess formation. RESULTS: Fourteen observational studies were included in this systematic review, comprising a total of 3092 patients with K. pneumoniae bacteraemia, including 746 (24.1%) patients with hmKp strains. The meta-analysis showed that hmKp bacteraemia did not account for a significant increase in the incidence of all-cause mortality compared with non-hmKp bacteraemia [pooled hazard ratio 1.30, 95% confidence interval (CI) 0.79-2.12; P=0.30]. However, hmKp bacteraemia was associated with a significant increase in the incidence of abscess formation compared with non-hmKp bacteraemia (pooled odds ratio 7.74, 95% CI 4.96-12.06; P<0.00001). CONCLUSIONS: Although mortality may not be dependent on the causative agent, this review reaffirms the importance of the string test to detect hmKp. There is a need for prudent management, especially for patients with hmKp, that should include investigations for liver abscess and/or metastatic spread, and measures for early and proper source control as this can improve the prognosis.

    DOI： 10.1016/j.ijantimicag.2023.106767

    PubMed

  • Predictors of hypervirulent Klebsiella pneumoniae infections: a systematic review and meta-analysis. Reviewed

    H Namikawa, K-I Oinuma, K Yamada, Y Kaneko, H Kakeya, T Shuto

    The Journal of hospital infection   134   153 - 160   2023.04（ ISSN:0195-6701 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND: Hypervirulent Klebsiella pneumoniae (hvKp) infections confer notable morbidity and mortality. Differential diagnosis to determine whether the infections are caused by either the hvKp or classical K. pneumoniae (cKp) strain is particularly important for undertaking optimal clinical care and infection control efforts. AIM: To identify and assess the potential predictors of hvKp infections. METHODS: PubMed, Web of Science, and Cochrane Library databases were searched for all relevant publications from January 2000 to March 2022. The search terms included a combination of the following terms: (i) Klebsiella pneumoniae or K. pneumoniae and (ii) hypervirulent or hypervirulence. A meta-analysis of factors for which risk ratio was reported in three or more studies was conducted, and at least one statistically significant association was identified. FINDINGS: In this systematic review of 11 observational studies, a total of 1392 patients with K. pneumoniae infection and 596 (42.8%) with hvKp strains were evaluated. In the meta-analysis, diabetes mellitus and liver abscess (pooled risk ratio: 2.61 (95% confidence interval: 1.79-3.80) and 9.04 (2.58-31.72), respectively; all P < 0.001) were predictors of hvKp infections. CONCLUSION: For patients with a history of the abovementioned predictors, prudent management, including the search for multiple sites of infection and/or metastatic spread and the enforcement of an early and appropriate source control procedure, should be initiated in consideration of the potential presence of hvKp. We believe that this research highlights the urgent need for increasing clinical awareness of the management of hvKp infections.

    DOI： 10.1016/j.jhin.2023.02.005

    PubMed

  • Rifampicin exerts anti-mucoviscous activity against hypervirulent Klebsiella pneumoniae via binding to the RNA polymerase β subunit. Reviewed

    Mitsunori Tohda, Ken-Ichi Oinuma, Arata Sakiyama, Taishi Tsubouchi, Mamiko Niki, Hiroki Namikawa, Kenshi Yamane, Koichi Yamada, Tetsuya Watanabe, Kazuhisa Asai, Hiroshi Kakeya, Yukihiro Kaneko, Tomoya Kawaguchi

    Journal of global antimicrobial resistance   32   21 - 28   2023.03（ ISSN:2213-7165 ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    OBJECTIVES: In hypervirulent Klebsiella pneumoniae (hvKP), the hypermucoviscous capsule is known to be a major virulence determinant. We previously discovered that rifampicin (RFP), a bactericidal drug that binds to and inhibits the β subunit of RNA polymerase (RpoB), elicits anti-mucoviscous activity against hvKP by suppressing rmpA, a regulator of capsule production. Here, we aimed to determine whether RFP exerts this effect at sub-growth-inhibitory concentrations via its binding to RpoB. METHODS: Five spontaneous RFP-resistant mutants (R1-R5) were prepared from an hvKP clinical isolate and subjected to whole genome sequencing and mucoviscosity analyses. Subsequently, a two-step allelic exchange procedure was used to create a rpoB mutant R6 and revertants with wild-type rpoB from R1-R5 (named R1'-R5'). Transcription levels of rmpA and the capsular polysaccharide polymerase gene magA and capsule thickness of R1-R5 and R1'-R5' grown without or with RFP were evaluated by quantitative reverse transcription polymerase chain reaction and microscopic observation using India ink staining. RESULTS: R1-R5 all had non-synonymous point mutations in rpoB and were highly resistant to the bactericidal effects and anti-mucoviscous activity of RFP. While the properties of R6 were similar to those of R1-R5, the responses of R1'-R5' to RFP were identical to those of the wild type. rmpA and magA transcription levels and capsule thickness correlated well with the mucoviscosity levels. CONCLUSIONS: RFP exerts anti-mucoviscous activity by binding to RpoB. The mechanism of how this causes rmpA suppression remains to be explored.

    DOI： 10.1016/j.jgar.2022.11.018

    PubMed

  • Discovery of a LuxR-type regulator involved in isoniazid-dependent gene regulation in Mycobacterium smegmatis. Reviewed

    Arata Sakiyama, Ken-Ichi Oinuma, Yukihiro Kaneko

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy   29 ( 3 )   322 - 328   2023.03（ ISSN:1341-321X ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    OBJECTIVE: Most non-tuberculous mycobacteria exhibit intrinsic resistance against the anti-tuberculosis drug isoniazid (INH). We previously found that a pyrazinamidase/nicotinamidase of Mycobacterium smegmatis, named PzaA, has an enzymatic activity to hydrolyze INH, which may contribute to intrinsic resistance. Furthermore, PzaA expression is strongly induced by INH under nitrogen-depleted conditions, although the precise mechanism of this phenomenon remains unclear. Here, we aimed to reveal the mechanism underlying the INH-dependent induction of PzaA using a transcriptomic approach. METHODS: RNA sequencing was performed to identify INH-inducible genes other than pzaA. 5' rapid amplification of cDNA ends analysis was employed to identify the transcription start sites of INH-induced transcription units. The function of a LuxR-like regulator gene (MSMEI_1050) found within the gene cluster containing pzaA was confirmed by gene deletion and complementation experiments involving INH hydrolysis assay and quantitative reverse transcription PCR. RESULTS: RNA sequencing revealed 23 genes that INH strongly induced under conditions of nitrogen depletion, 17 of which were in a gene cluster containing pzaA. This cluster comprised at least three transcription units, including a non-INH-inducible monocistronic unit containing MSMEI_1050. Deletion of this gene deprived M. smegmatis of the ability to respond to INH, and complementation restored this ability. CONCLUSIONS: MSMEI_1050 plays a key role in INH-dependent gene regulation. The precise mechanism of action is to be determined in future studies.

    DOI： 10.1016/j.jiac.2022.12.011

    PubMed

    Repository URL： http://hdl.handle.net/10466/0002000443

  • A Culture Supernatant from an Actinomycete sp. Affects Biofilm Formation and Virulence Expression of Candida auris(和訳中) Reviewed

    Yamane Kenshi, Niki Mamiko, Tsubouchi Taishi, Watanabe Tetsuya, Asai Kazuhisa, Oinuma Ken-Ichi, Sakiyama Arata, Saren Chaogetu, Matsumoto Yuki, Makimura Koichi, Kaneko Yukihiro, Kawaguchi Tomoya

    Medical Mycology Journal   64 ( 1 )   7 - 17   2023.01（ ISSN:2185-6486 ）

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    Publishing type：Research paper (scientific journal)  

  • Siderophore production as a biomarker for Klebsiella pneumoniae strains that cause sepsis: A pilot study. Reviewed

    Hiroki Namikawa, Makoto Niki, Mamiko Niki, Ken-Ichi Oinuma, Koichi Yamada, Kiyotaka Nakaie, Taishi Tsubouchi, Yoshihiro Tochino, Yasuhiko Takemoto, Yukihiro Kaneko, Hiroshi Kakeya, Taichi Shuto

    Journal of the Formosan Medical Association = Taiwan yi zhi   121 ( 4 )   848 - 855   2022.04（ ISSN:0929-6646 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    BACKGROUND/PURPOSE: Klebsiella pneumoniae bacteremia-induced sepsis is a clinically important condition with a high mortality rate and various known virulence factors. However, studies on the association of these virulence factors with the occurrence of K. pneumoniae bacteremia-induced sepsis are scarce. We aimed to investigate clinical variables and virulence factors in patients with K. pneumoniae bacteremia-induced sepsis. METHODS: We retrospectively reviewed the medical records of 76 patients with K. pneumoniae bacteremia between January 2012 and July 2017. Patients were divided into sepsis (n = 25) and non-sepsis (n = 51) groups. Patient background characteristics, antimicrobial regimens, and prognosis were evaluated. We assessed the distribution of virulence factors related to K. pneumoniae, such as mucoviscosity, capsular polysaccharide, and siderophores. Siderophore production levels were determined by measuring the orange halo zone on chrome azurol S agar plate assay. RESULTS: There were no intergroup differences in male-to-female ratio and age. Multivariable analysis revealed that siderophore production level (p < 0.01) was an independent predictor of K. pneumoniae bacteremia-induced sepsis. Furthermore, the optimal cut-off point of siderophore production to predict sepsis was 9.6 mm (sensitivity, 86%; specificity, 76%; AUC, 0.81). CONCLUSION: Siderophore production was an independent predictor of sepsis caused by K. pneumoniae bacteremia. The optimal cut-off point for siderophore production for sepsis occurrence prediction was 9.6 mm. To improve outcomes, patients with K. pneumoniae bacteremia-induced sepsis with high siderophore production levels should be managed prudently.

    DOI： 10.1016/j.jfma.2021.06.027

    PubMed

  • Genomic characterization of triple-carbapenemase-producing Acinetobacter baumannii Reviewed

    Ken-Ichi Oinuma, Masato Suzuki, Arata Sakiyama, Taishi Tsubouchi, Kozo Saeki, Kanako Sato, Mamiko Niki, Koichi Yamada, Keigo Shibayama, Hiroshi Kakeya, Yukihiro Kaneko

    JAC-Antimicrobial Resistance   3 ( 4 )   dlab191   2021.12

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    <title>Abstract</title>
    <sec>
    <title>Objectives</title>
    To characterize Acinetobacter baumannii OCU_Ac16a, a clinical isolate co-harbouring three acquired carbapenemase genes, blaNDM-1, blaTMB-1, and blaOXA-58, and assess the clinical significance of so-called multiple-carbapenemase producers.


    </sec>
    <sec>
    <title>Methods</title>
    OCU_Ac16a and its close relative, OCU_Ac16b, which lacks the blaNDM-1, were isolated from sputum cultures of a patient at Osaka City University Hospital. We subjected these strains to whole-genome analysis, particularly focusing on the genetic context of each carbapenemase gene. The transmissibility and functionality of each carbapenemase gene were analysed by conjugation and transformation experiments and antimicrobial susceptibility tests.


    </sec>
    <sec>
    <title>Results</title>
    bla TMB-1 was located in a class 1 integron on the chromosome, whereas blaNDM-1 and blaOXA-58 were found on plasmids named pOCU_Ac16a_2 and pOCU_Ac16a_3, respectively. pOCU_Ac16a_2 (which exhibited highly efficient self-transmissibility) and pOCU_Ac16a_3 (which did not show transmissibility but could be introduced into another A. baumannii strain via electroporation) could both confer carbapenem resistance (MICs ≥512 and ≥32 mg/L, respectively) on the recipient strain. The functionality of blaTMB-1 was evident from the high resistance of OCU_Ac16b to ceftazidime and cefepime (MICs ≥256 and 48 mg/L, respectively), and the high resistance of OCU_Ac16a to cefiderocol (MIC 32 mg/L) could be explained by the additive effect of blaNDM-1 and blaTMB-1.


    </sec>
    <sec>
    <title>Conclusions</title>
    Our data revealed the genomic organization of OCU_Ac16a and demonstrated that all the carbapenemase genes are functional, each contributing to the extremely high broad-spectrum resistance of OCU_Ac16a to β-lactams. As multiple-carbapenemase producers can be serious health threats as drug-resistant pathogens and disseminators of carbapenemase genes, close attention should be paid to their emergence.


    </sec>

    DOI： 10.1093/jacamr/dlab191

    PubMed

  • Complete Genome Sequence of a Clinical Isolate of Acinetobacter baumannii Harboring 11 Plasmids. Reviewed

    Sakiyama A, Matsumoto Y, Tsubouchi T, Suzuki M, Niki M, Niki M, Oinuma KI, Kakeya H, Kaneko Y

    Microbiology resource announcements   10 ( 39 )   e0069521   2021.09

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/MRA.00695-21

    PubMed

  • Nutritional status positively impacts humoral immunity against its Mycobacterium tuberculosis, disease progression, and vaccine development Reviewed

    Niki Mamikoc, Yoshiyama Takashi, Nagai Hideaki, Miyamoto Yuji, Niki Makoto, Oinuma Ken-ichi, Tsubouchi Taishi, Kaneko Yukihiro, Matsumoto Sohkichi, Sasaki Yuka, Hoshino Yoshihiko

    PLOS ONE   15 ( 8 )   e0237062   2020.08（ ISSN:1932-6203 ）

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    Publishing type：Research paper (scientific journal)  

    Nutritional status contributes to the regulation of immune responses against pathogens, and malnutrition has been considered as a risk factor for tuberculosis (TB). Mycobacterium tuberculosis (Mtb), the causative agent of TB, can modulate host lipid metabolism and induce lipid accumulation in macrophages, where the bacilli adopt a dormant phenotype. In addition, serum lipid components play dual roles in the regulation of and protection from Mtb infection. We analyzed the relationship between nutritional status and the humoral immune response in TB patients. We found that serum HDL levels are positively correlated with the serum IgA specific for Mtb antigens. Analysis of the relationship between serum nutritional parameters and clinical parameters in TB patients showed that serum albumin and CRP levels were negatively correlated before treatment. We also observed reduced serum LDL levels in TB patients following treatment. These findings may provide insight into the role of serum lipids in host immune responses against Mtb infection. Furthermore, improving the nutritional status may enhance vaccination efficacy.

    DOI： 10.1371/journal.pone.0237062

    PubMed

  • Complete Genome Sequence of Acinetobacter baumannii ATCC 19606(T), a Model Strain of Pathogenic Bacteria Causing Nosocomial Infection Reviewed

    Tsubouchi Taishi, Suzuki Masato, Niki Makoto, Oinuma Ken-Ichi, Niki Mamiko, Kakeya Hiroshi, Kaneko Yukihiro

    MICROBIOLOGY RESOURCE ANNOUNCEMENTS   9 ( 20 )   2020.05（ ISSN:2576-098X ）

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    Publishing type：Research paper (scientific journal)  

    Acinetobacter baumannii ATCC 19606T, which is often used in genetic studies as a routine model microorganism, belongs to sequence type 52 (ST52), showing beta-lactam resistance. We present the complete 3.996-Mbp genome sequence (1 chromosome plus 2 plasmids), generated by combining long-read (MinION) and short-read (MiniSeq) sequencing data.

    DOI： 10.1128/MRA.00289-20

    PubMed

  • 高粘稠性Klebsiella pneumoniaeに対するリファンピシンの有用性 Invited

    並川 浩己, 老沼 研一, 金子 幸弘, 掛屋 弘

    (公財)日本感染症医薬品協会　The Japanese Journal of Antibiotics   72 ( 4 )   301 - 306   2019.12（ ISSN:0368-2781 ）

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    Publishing type：Research paper (scientific journal)  

    近年、日本を含めた東・東南アジアを中心として、高粘稠性のKlebsiella pneumoniae(hvKP)が臨床上問題となっている。本菌の高病原性には、莢膜多糖合成遺伝子であるregulator of mucoid phenotype A(rmpA)等の働きによる莢膜多糖の過剰産生が関与している。今までhvKPの高病原性のメカニズムに関する研究は数多くされてきているが、抗病原性療法に焦点をあてた研究はない。我々は、hvKPの高粘稠性を抑制することができる薬剤を既存の抗菌薬の中から探索した。結果、リファンピシン(RFP)に強い粘稠性抑制作用があることを発見した。またRFPは莢膜の厚さを減少させ、さらにrmpAを中心とした莢膜関連遺伝子の転写を抑制することが判明した。以上のことから、リファンピシンが本菌による難治性感染症に対する治療薬として役立つ可能性があることが示唆された。(著者抄録)

  • Clinical and virulence factors related to the 30-day mortality of Klebsiella pneumoniae bacteremia at a tertiary hospital: a case-control study Reviewed

    Namikawa Hiroki, Niki Makoto, Niki Mamiko, Yamada Koichi, Nakaie Kiyotaka, Sakiyama Arata, Oinuma Ken-Ichi, Tsubouchi Taishi, Tochino Yoshihiro, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES   38 ( 12 )   2291 - 2297   2019.10（ ISSN:0934-9723 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s10096-019-03676-y

    PubMed

  • Clinical characteristics of bacteremia caused by hypermucoviscous Klebsiella pneumoniae at a tertiary hospital Reviewed

    Namikawa Hiroki, Yamada Koichi, Sakiyama Arata, Imoto Waki, Yamairi Kazushi, Shibata Wataru, Yoshii Naoko, Niki Makoto, Nakaie Kiyotaka, Oinuma Ken-Ichi, Tsubouchi Taishi, Niki Mamiko, Tochino Yoshihiro, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE   95 ( 1 )   84 - 88   2019.09（ ISSN:0732-8893 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.diagmicrobio.2019.04.008

    PubMed

  • Discovery of anti-mucoviscous activity of rifampicin and its potential as a candidate antivirulence agent against hypervirulent Klebsiella pneumoniae Reviewed

    Namikawa Hiroki, Oinuma Ken-Ichi, Sakiyama Arata, Tsubouchi Taishi, Tahara Yuhei O., Yamada Koichi, Niki Mamiko, Takemoto Yasuhiko, Miyata Makoto, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS   54 ( 2 )   167 - 175   2019.08（ ISSN:0924-8579 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.ijantimicag.2019.05.018

    PubMed

  • Mortality caused by extended-spectrum beta-lactamase-producing Enterobacteriaceae bacteremia; a case control study: alert to Enterobacteriaceae strains with high minimum inhibitory concentrations of piperacillin/tazobactam. Reviewed

    Hiroki Namikawa, Koichi Yamada, Kazushi Yamairi, Wataru Shibata, Hiroki Fujimoto, Etsuko Takizawa, Makoto Niki, Kiyotaka Nakaie, Ken-Ichi Oinuma, Mamiko Niki, Yasuhiko Takemoto, Yukihiro Kaneko, Taichi Shuto, Hiroshi Kakeya

    Diagnostic microbiology and infectious disease   94 ( 3 )   287 - 292   2019.07（ ISSN:0732-8893 ）

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    Publishing type：Research paper (scientific journal)  

    This study aimed to assess the prognostic factors of patients with bacteremia due to extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE) as well as the antimicrobial susceptibility, particularly to piperacillin/tazobactam (PTZ), among ESBL-PE strains. The medical records of 65 patients with ESBL-PE bacteremia divided into the survivor group (n = 52) and nonsurvivor group (n = 13) were retrospectively reviewed. The male-to-female ratio, age, underlying disease, leukocyte count, C-reactive protein level, and treatment did not differ between the 2 groups. Multivariate analysis showed that the independent predictors associated with hospital mortality of ESBL-PE bacteremia were sepsis (P = 0.047) and febrile neutropenia (P = 0.008); thus, early assessment of these conditions is important. Further, the minimum inhibitory concentration values of ESBL-PE isolates in nonsurvivors tended to be higher than those in survivors. PTZ should be used with caution in cases of ESBL-PE strains with low susceptibility to the drug.

    DOI： 10.1016/j.diagmicrobio.2019.01.018

    PubMed

  • Genome-Based Epidemiological Analysis of 13 Acinetobacter Strains Isolated from Blood Cultures of Hospitalized Patients from a University Hospital in Japan Reviewed

    Oinuma Ken-Ichi, Suzuki Masato, Nakaie Kiyotaka, Sato Kanako, Saeki Kozo, Sakiyama Arata, Takizawa Etsuko, Niki Makoto, Niki Mamiko, Yamada Koichi, Shibayama Keigo, Kakeya Hiroshi, Kaneko Yukihiro

    国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会　JAPANESE JOURNAL OF INFECTIOUS DISEASES   72 ( 4 )   274 - 280   2019.07（ ISSN:1344-6304 ）

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    Publishing type：Research paper (scientific journal)  

    <p>The genus <i>Acinetobacter</i> comprises many species that can cause infectious diseases. Despite their importance as nosocomial pathogens, the clinical distributions of individual species or clones are not well understood. In this study, we aimed to characterize 13 <i>Acinetobacter</i> strains isolated from blood cultures from Osaka City University Hospital. We conducted whole-genome sequencing to reveal their genetic background. We also performed PCR-based open reading frame typing (POT) and compared the results with those of multilocus sequence typing (MLST) to confirm its reliability as a genotyping method. Although biochemical analysis suggested that most isolates were <i>A. baumannii</i>, genomic analysis revealed that the collection of <i>Acinetobacter</i> isolates comprised six different species, with non-<i>baumannii Acinetobacter</i> species representing the majority. All strains possessed an inherent ADC-type β-lactamase gene, whereas the distribution of OXA-type enzymes was limited to <i>A. baumannii, A. pittii</i>, and <i>A. colistiniresistens</i>. While MLST properly discriminated four <i>A. baumannii</i> strains as different clones, POT failed to distinguish three of the four <i>A. baumannii</i> strains from each other, highlighting a potential pitfall that may be encountered when applying POT to non-epidemiological <i>A. baumannii</i> strains.</p>

    DOI： 10.7883/yoken.JJID.2018.403

    CiNii Article

  • Extracytoplasmic diaphorase activity of Streptomyces coelicolor A3(2) Reviewed

    Oinuma Ken-Ichi, Yamaguchi Itaru, Shindo Daiki, Fujimoto Masahiro, Nishiyama Tatsuya, Takano Hideaki, Takaya Naoki, Ueda Kenji

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   503 ( 3 )   1581 - 1586   2018.09（ ISSN:0006-291X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2018.07.083

    PubMed

  • The Pseudomonas aeruginosa Orphan Quorum Sensing Signal Receptor QscR Regulates Global Quorum Sensing Gene Expression by Activating a Single Linked Operon Reviewed

    Ding Fengming, Oinuma Ken-Ichi, Smalley Nicole E., Schaefer Amy L., Hamwy Omar, Greenberg E. Peter, Dandekar Ajai A.

    MBIO   9 ( 4 )   2018.08（ ISSN:2150-7511 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/mBio.01274-18

    PubMed

  • Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients Reviewed

    Niki Mamiko, Yoshiyama Takashi, Miyamoto Yuji, Okumura Masao, Niki Makoto, Oinuma Ken-ichi, Kaneko Yukihiro, Matsumoto Sohkichi, Sasaki Yuka, Ogata Hideo, Goto Hajime, Kudoh Shoji, Hoshino Yoshihiko

    JOURNAL OF IMMUNOLOGY RESEARCH   2018   4928757   2018.07（ ISSN:2314-8861 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1155/2018/4928757

    PubMed

  • Two-Component Flavin-Dependent Riboflavin Monooxygenase Degrades Riboflavin in Devosia riboflavina. Reviewed

    Kanazawa H, Shigemoto R, Kawasaki Y, Oinuma KI, Nakamura A, Masuo S, Takaya N

    Journal of bacteriology   200 ( 12 )   2018.06（ ISSN:0021-9193 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1128/JB.00022-18

    PubMed

  • NOVEL ANTIOXIDANT ISOLATED FROM WARCUPIELLA SPINULOSA JCM 2358, 7-HYDROXYCORDYLACTAM Reviewed

    Shigemoto, Ryosuke, Oinuma, Ken-Ichi, Masuo, Shunsuke, Takaya, Naoki

    PERGAMON-ELSEVIER SCIENCE LTD, HETEROCYCLES   96 ( 6 )   1075 - 1079   2018.06（ ISSN:0385-5414 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3987/COM-18-13895

  • Successful Treatment of Intestinal Mycosis Caused by a Simultaneous Infection with Lichtheimia ramosa and Aspergillus calidoustus Reviewed

    Kaneko Yukihiro, Oinuma Ken-Ichi, Terachi Tsuneko, Arimure Yasuaki, Niki Mamiko, Yamada Koichi, Kakeye Hiroshi, Mizutani Tetsu

    INTERNAL MEDICINE   57 ( 16 )   2421 - 2424   2018（ ISSN:0918-2918 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.2169/internalmedicine.0254-17

  • Clinical Characteristics and Low Susceptibility to Daptomycin in Enterococcus faecium Bacteremia Reviewed

    Namikawa Hiroki, Yamada Koichi, Shibata Wataru, Fujimoto Hiroki, Takizawa Etsuko, Niki Makoto, Nakaie Kiyotaka, Nakamura Yasutaka, Oinuma Ken-Ichi, Niki Mamiko, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    東北ジャーナル刊行会　TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE   243 ( 3 )   211 - 218   2017.11（ ISSN:0040-8727 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1620/tjem.243.211

    PubMed

    CiNii Article

  • Identification of a Novel Rhizopus-specific Antigen by Screening with a Signal Sequence Trap and Evaluation as a Possible Diagnostic Marker of Mucormycosis Reviewed

    Sato Kanako, Oinuma Ken-Ichi, Niki Mamiko, Yamagoe Satoshi, Miyazaki Yoshitsugu, Asai Kazuhisa, Yamada Koichi, Hirata Kazuto, Kaneko Yukihiro, Kakeya Hiroshi

    MEDICAL MYCOLOGY   55 ( 7 )   713 - 719   2017.10（ ISSN:1369-3786 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1093/mmy/myw146

    PubMed

  • Sirtuin A regulates secondary metabolite production by Aspergillus nidulans. Reviewed

    Itoh E, Shigemoto R, Oinuma K, Shimizu M, Masuo S, Takaya N

    The Journal of general and applied microbiology   63 ( 4 )   228 - 235   2017.09（ ISSN:0022-1260 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.2323/jgam.2016.11.002

    PubMed

  • Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase. Reviewed

    Itoh E, Odakura R, Oinuma K, Shimizu M, Masuo S, Takaya N

    The Journal of biological chemistry   292 ( 26 )   11043 - 11054   2017.06（ ISSN:0021-9258 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1074/jbc.M116.753772

    PubMed

  • Structural basis of the substrate recognition of hydrazidase isolated from Microbacterium sp. strain HM58-2, which catalyzes acylhydrazide compounds as its sole carbon source. Reviewed

    Akiyama T, Ishii M, Takuwa A, Oinuma K, Sasaki Y, Takaya N, Yajima S

    Biochemical and biophysical research communications   482 ( 4 )   1007 - 1012   2017.01（ ISSN:0006-291X ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1016/j.bbrc.2016.11.148

    PubMed

  • Clinical Characteristics of Bacteremia Caused by Extended-spectrum Beta-lactamase-producing Escherichia coli at a Tertiary Hospital Reviewed

    Namikawa Hiroki, Yamada Koichi, Fujimoto Hiroki, Oinuma Ken-Ichi, Tochino Yoshihiro, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    一般社団法人 日本内科学会　INTERNAL MEDICINE   56 ( 14 )   1807 - 1815   2017（ ISSN:0918-2918 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.2169/internalmedicine.56.7702

    PubMed

    CiNii Article

  • Genome Sequence of an Acinetobacter baumannii Strain Carrying Three Acquired Carbapenemase Genes. Reviewed

    Oinuma K, Suzuki M, Sato K, Nakaie K, Niki M, Takizawa E, Niki M, Shibayama K, Yamada K, Kakeya H, Kaneko Y

    Genome announcements   4 ( 6 )   2016.11

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1128/genomeA.01290-16

    PubMed

  • Two unusual cases of successful treatment of hypermucoviscous Klebsiella pneumoniae invasive syndrome Reviewed

    Namikawa Hiroki, Yamada Koichi, Fujimoto Hiroki, Oinuma Ken-Ichi, Tochino Yoshihiro, Takemoto Yasuhiko, Kaneko Yukihiro, Shuto Taichi, Kakeya Hiroshi

    BMC INFECTIOUS DISEASES   16 ( 1 )   680   2016.11（ ISSN:1471-2334 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1186/s12879-016-2011-3

    PubMed

  • Alternative fermentation pathway of cinnamic acid production via phenyllactic acid. Reviewed

    Masuo S, Kobayashi Y, Oinuma K, Takaya N

    Applied microbiology and biotechnology   100 ( 20 )   8701 - 9   2016.10（ ISSN:0175-7598 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1007/s00253-016-7623-4

    PubMed

  • Draft Genome Sequence of Microbacterium sp. Strain HM58-2, Which Hydrolyzes Acylhydrazides. Reviewed

    Akiyama T, Ishige T, Kanesaki Y, Ito S, Oinuma K, Takaya N, Sasaki Y, Yajima S

    Genome announcements   4 ( 3 )   2016.06

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1128/genomeA.00554-16

    PubMed

  • An Intrinsic Strain of Colistin-resistant Acinetobacter Isolated from a Japanese Patient Reviewed

    Takizawa Etsuko, Yamada Koichi, Oinuma Ken-Ichi, Sato Kanako, Niki Mamiko, Namikawa Hiroki, Fujimoto Hiroki, Asai Kazuhisa, Kaneko Yukihiro, Kakeya Hiroshi

    一般社団法人 日本内科学会　INTERNAL MEDICINE   55 ( 16 )   2301 - 2306   2016（ ISSN:0918-2918 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.2169/internalmedicine.55.6807

    PubMed

    CiNii Article

  • Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse. Reviewed

    Kawaguchi H, Teramura H, Uematsu K, Hara KY, Hasunuma T, Hirano K, Sazuka T, Kitano H, Tsuge Y, Kahar P, Niimi-Nakamura S, Oinuma K, Takaya N, Kasuga S, Ogino C, Kondo A

    Bioresource technology   182   169 - 78   2015.04（ ISSN:0960-8524 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1016/j.biortech.2015.01.097

    PubMed

  • Hydrazidase, a novel amidase signature enzyme that hydrolyzes acylhydrazides. Reviewed

    Oinuma K, Takuwa A, Taniyama K, Doi Y, Takaya N

    Journal of bacteriology   197 ( 6 )   1115 - 24   2015.03（ ISSN:0021-9193 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1128/JB.02443-14

    PubMed

  • Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production Reviewed

    Kawaguchi H, Uematsu K, Ogino C, Teramura H, Niimi-Nakamura S, Tsuge Y, Hasunuma T, Oinuma K, Takaya N, Kondo A

    Biochemical Engineering Journal   88   188 - 194   2014.05

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

  • Divergent effects of desferrioxamine on bacterial growth and characteristics. Reviewed

    Eto D, Watanabe K, Saeki H, Oinuma K, Otani K, Nobukuni M, Shiratori-Takano H, Takano H, Beppu T, Ueda K

    The Journal of antibiotics   66 ( 4 )   199 - 203   2013.04（ ISSN:0021-8820 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1038/ja.2012.111

    PubMed

  • Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis. Reviewed

    Nomura J, Hashimoto H, Ohta T, Hashimoto Y, Wada K, Naruta Y, Oinuma K, Kobayashi M

    Proceedings of the National Academy of Sciences of the United States of America   110 ( 8 )   2810 - 5   2013.02（ ISSN:0027-8424 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1073/pnas.1200338110

    PubMed

  • Crystal structure of QscR, a Pseudomonas aeruginosa quorum sensing signal receptor. Reviewed International coauthorship

    Lintz MJ, Oinuma K, Wysoczynski CL, Greenberg EP, Churchill ME

    Proceedings of the National Academy of Sciences of the United States of America   108 ( 38 )   15763 - 8   2011.09（ ISSN:0027-8424 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1073/pnas.1112398108

    PubMed

  • Acyl-homoserine lactone binding to and stability of the orphan Pseudomonas aeruginosa quorum-sensing signal receptor QscR. Reviewed International coauthorship

    Oinuma K, Greenberg EP

    Journal of bacteriology   193 ( 2 )   421 - 8   2011.01（ ISSN:0021-9193 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1128/JB.01041-10

    PubMed

  • Reversible signal binding by the Pseudomonas aeruginosa quorum-sensing signal receptor LasR. Reviewed International coauthorship

    Sappington KJ, Dandekar AA, Oinuma K, Greenberg EP

    mBio   2 ( 1 )   e00011 - 11   2011

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1128/mBio.00011-11

    PubMed

  • Quorum-sensing-regulated bactobolin production by Burkholderia thailandensis E264. Reviewed International coauthorship

    Seyedsayamdost MR, Chandler JR, Blodgett JA, Lima PS, Duerkop BA, Oinuma K, Greenberg EP, Clardy J

    Organic letters   12 ( 4 )   716 - 9   2010.02（ ISSN:1523-7060 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1021/ol902751x

    PubMed

  • Transcriptional regulation of the nitrile hydratase gene cluster in Pseudomonas chlororaphis B23. Reviewed

    Sakashita T, Hashimoto Y, Oinuma K, Kobayashi M

    Journal of bacteriology   190 ( 12 )   4210 - 7   2008.06（ ISSN:0021-9193 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1128/JB.00061-08

    PubMed

  • Discovery and characterization of a novel aliphatic aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis

    老沼　研一

    筑波大学   2006.03

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    Publishing type：Doctoral thesis   Kind of work：Single Work  

  • Discovery of a reaction intermediate of aliphatic aldoxime dehydratase involving heme as an active center. Reviewed

    Konishi K, Ohta T, Oinuma K, Hashimoto Y, Kitagawa T, Kobayashi M

    Proceedings of the National Academy of Sciences of the United States of America   103 ( 3 )   564 - 8   2006.01（ ISSN:0027-8424 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1073/pnas.0505412103

    PubMed

  • Nitrile pathway involving acyl-CoA synthetase: overall metabolic gene organization and purification and characterization of the enzyme. Reviewed

    Hashimoto Y, Hosaka H, Oinuma K, Goda M, Higashibata H, Kobayashi M

    The Journal of biological chemistry   280 ( 10 )   8660 - 7   2005.03（ ISSN:0021-9258 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1074/jbc.M405686200

    PubMed

  • Stopped-flow spectrophotometric and resonance Raman analyses of aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis. Reviewed

    Oinuma K, Kumita H, Ohta T, Konishi K, Hashimoto Y, Higashibata H, Kitagawa T, Shiro Y, Kobayashi M

    FEBS letters   579 ( 6 )   1394 - 8   2005.02（ ISSN:0014-5793 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1016/j.febslet.2005.01.037

    PubMed

  • Identification of crucial histidines involved in carbon-nitrogen triple bond synthesis by aldoxime dehydratase. Reviewed

    Konishi K, Ishida K, Oinuma K, Ohta T, Hashimoto Y, Higashibata H, Kitagawa T, Kobayashi M

    The Journal of biological chemistry   279 ( 46 )   47619 - 25   2004.11（ ISSN:0021-9258 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1074/jbc.M407223200

    PubMed

  • Heme environment in aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis. Reviewed

    Oinuma K, Ohta T, Konishi K, Hashimoto Y, Higashibata H, Kitagawa T, Kobayashi M

    FEBS letters   568 ( 1-3 )   44 - 8   2004.06（ ISSN:0014-5793 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1016/j.febslet.2004.05.008

    PubMed

  • Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. Sequencing, gene expression, purification, and characterization. Reviewed

    Oinuma K, Hashimoto Y, Konishi K, Goda M, Noguchi T, Higashibata H, Kobayashi M

    The Journal of biological chemistry   278 ( 32 )   29600 - 8   2003.08（ ISSN:0021-9258 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    DOI： 10.1074/jbc.M211832200

    PubMed

  • Site-directed mutagenesis for cysteine residues of cobalt-containing nitrile hydratase. Reviewed

    Hashimoto Y, Sasaki S, Herai S, Oinuma K, Shimizu S, Kobayashi M

    Journal of inorganic biochemistry   91 ( 1 )   70 - 7   2002.07（ ISSN:0162-0134 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    PubMed

  • AmfS, an extracellular peptidic morphogen in Streptomyces griseus. Reviewed

    Ueda K, Oinuma K, Ikeda G, Hosono K, Ohnishi Y, Horinouchi S, Beppu T

    Journal of bacteriology   184 ( 5 )   1488 - 92   2002.03（ ISSN:0021-9193 ）

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

    PubMed

▼display all

Books and Other Publications

MISC

  • 【エキスパートに聞く 耐性菌と院内感染-産婦人科医に必要な基礎知識】耐性菌総論　検出菌と原因菌　感染症治療の考え方 International journal

    榮山 新, 老沼 研一, 金子 幸弘

    臨床婦人科産科   75 ( 8 )   721 - 728   2021.08（ ISSN:0386-9865 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine：Domestic journal  

    ＜文献概要＞●抗菌薬の適正使用とは,不必要な使用を避けつつ,必要な場合には,適切な抗菌薬の選択に加え,適切な投与経路で,量・期間ともに十分に使用することである.●原因菌や抗菌薬の特性を理解したうえで,検査の意義を十分に吟味し,「念のため」の抗菌薬使用や「とりあえず」の広域抗菌薬の選択を避ける.●耐性菌が検出された場合には,治療対象となるかどうかの判断に加え,接触予防策などの感染対策が必要となる.

  • ヒドラジン類縁化合物の微生物代謝 明らかとなった新規分解機構 Invited

    老沼　研一, 高谷　直樹

    化学と生物 (日本農芸化学会 学会誌)   54 ( 4 )   228 - 230   2016.03

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Joint Work  

  • 多様な微生物代謝を利用した芳香族バイオ素材の開発 Invited

    桝尾　俊介, 老沼　研一, 高谷　直樹

    ケミカルエンジニヤリング (株式会社 化学工業社)   58 ( 8 )   38 - 43   2013.08

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Joint Work  

  • 細菌のクオラムセンシング機構：アシルホモセリンラクトンレセプター研究の新展開 Invited

    老沼　研一

    B&I バイオサイエンスとインダストリー (一般財団法人 バイオインダストリー協会)   71 ( 2 )   138 - 141   2013.03

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Single Work  

  • クオラムセンシング研究の最前線 -孤立したシグナル受容体の役割を考える- Invited

    老沼　研一

    生物工学会誌   90 ( 6 )   350 - 350   2012.06

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   Kind of work：Single Work  

Presentations

  • Acinetobacter baumannii OCU_Ac16b株の莢膜型転換メカニズムの解析 Domestic conference

    薩仁朝格吐, 榮山 新, 老沼 研一, 鈴木 仁人, 坪内 泰志, 仁木 満美子, 金子 幸弘

    第58回緑膿菌感染症研究会  2024.01  緑膿菌感染症研究会

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    Presentation type：Oral presentation (general)  

  • Mycobacterium smegmatisが有するイソニアジド依存的な遺伝子制御に関与するLuxR型制御因子の解析 Domestic conference

    榮山 新, 金子 幸弘, 老沼 研一

    第7回抗酸菌研究会  2023.11  抗酸菌研究会

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    Presentation type：Oral presentation (general)  

  • Acinetobacter baumannii OCU_Ac16b-L株の厚莢膜形成メカニズムの解析 Domestic conference

    薩仁 朝格吐, 榮山 新, 老沼 研一, 鈴木 仁人, 佐伯 康匠, 坪内 泰志, 仁木 満美子, 山田 康一, 柴山 恵吾, 掛屋 弘, 金子 幸弘

    第57回緑膿菌感染症研究会  2023.02  緑膿菌感染症研究会

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    Presentation type：Oral presentation (general)  

  • Mycobacterium smegmatisからのINH分解酵素の発見とその役割の解明 Domestic conference

    榮山 新, 薩仁朝格吐, 金子 幸弘, 老沼 研一

    第6回抗酸菌研究会  2022.11 

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    Presentation type：Oral presentation (general)  

    Venue：岡山国際交流センター  

  • リファンピシンの高病原性肺炎桿菌に対する粘性抑制作用機序の解明 (第64回日本感染症学会中日本地方会学術奨励賞受賞講演) Invited Domestic conference

    東田 充功, 老沼 研一, 並川 浩己, 榮山 新, 坪内 泰志, 山田 康一, 仁木 満美子, 渡辺 徹也, 浅井 一久, 掛屋 弘, 金子 幸弘, 川口 知哉

    第65回日本感染症学会中日本地方会学術集会  2022.11 

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    Presentation type：Oral presentation (invited, special)  

    Venue：出島メッセ長崎  

  • Persisterに対する抗菌化学療法 Invited Domestic conference

    老沼 研一

    第65回日本感染症学会中日本地方会学術集会  2022.11 

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    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：出島メッセ長崎  

  • Discovery and analysis of an isoniazid-hydrolyzing enzyme from Mycolicibacterium smegmatis International conference

    Arata Sakiyama, Chaogetu Saren, Ken-Ichi Oinuma, Yukihiro Kaneko

    ASM Microbe 2022  2022.06  American Society for Microbiology

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    Presentation type：Poster presentation  

    Venue：Washington D.C.（米国）  

  • RNA-seqを用いたMycolicibacterium smegmatisのイソニアジド分解酵素発現機序の解析 Domestic conference

    栄山 新，老沼 研一，金子 幸弘

    日本農芸化学会2022年度大会  2022.03 

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    Presentation type：Oral presentation (general)  

    Venue：京都（オンライン開催）  

  • Mycobacterium smegmatis由来PzaAの酵素学的特性と発現制御機構の解析 Domestic conference

    榮山 新, 薩仁朝格吐, 老沼 研一, 金子 幸弘

    日本農芸化学会2021年度大会  2021.03 

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    Presentation type：Oral presentation (general)  

  • 緑膿菌クオラムセンシング制御因子の研究 Invited Domestic conference

    老沼 研一

    第55回緑膿菌感染症研究会  2021.02 

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    Presentation type：Symposium, workshop panel (nominated)  

    Venue：大阪(オンライン開催)  

  • Acinetobacter baumannii OCU_Ac16aが保持するblaTMB-1とblaOXA-58の機能性の検討 Domestic conference

    榮山 新, 老沼 研一, 鈴木 仁人, 佐伯 康匠, 坪内 泰志, 仁木 満美子, 山田 康一, 柴山 恵吾, 掛屋 弘, 金子 幸弘

    第55回緑膿菌感染症研究会  2021.02 

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    Presentation type：Oral presentation (general)  

    Venue：大阪(オンライン開催)  

  • 当院で分離された多剤耐性Acinetobacter baumannii株の完全長ゲノム解析から見出した知見 Domestic conference

    藤本 凜太郎, 坪内 泰志, 鈴木 仁人, 仁木 誠, 仁木 満美子, 老沼 研一, 山田 康一, 掛屋 弘, 金子 幸弘

    第55回緑膿菌感染症研究会  2021.02 

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    Presentation type：Oral presentation (general)  

    Venue：大阪(オンライン開催)  

  • カルバペネマーゼ遺伝子多重保持株Acinetobacter baumannii OCU_Ac16aが有するblaTMB-1とblaOXA-58の機能性 Domestic conference

    榮山 新, 老沼 研一, 鈴木 仁人, 佐伯 康匠, 坪内 泰志, 仁木 満美子, 山田 康一, 柴山 恵吾, 掛屋 弘, 金子 幸弘

    第63回日本感染症学会中日本地方会学術集会  2020.11 

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    Presentation type：Oral presentation (general)  

  • 緑膿菌のAHLレセプターRhlRのN末端アミノ酸残基が本タンパク質の活性と可溶性に与える影響の検討 Domestic conference

    老沼 研一, 宮崎 裕太郎, 島内 幸啓, 笹野 敦也, 金子 幸弘

    日本バイオフィルム学会学術集会  2020.08  日本バイオフィルム学会

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    Presentation type：Oral presentation (general)  

  • 緑膿菌クオラムセンシング制御因子RhlRの組換え大腸菌を用いた機能解析 Domestic conference

    老沼 研一, 矢守 志穏, 松岡 俊佑, 金子 幸弘

    第54回緑膿菌感染症研究会  2020.02 

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    Presentation type：Oral presentation (general)  

    Venue：長良川国際会議場  

  • Mycobacterium smegmatisが有するINH分解酵素の同定 Domestic conference

    榮山 新, 薩仁朝格吐, 老沼 研一, 金子 幸弘

    第4回 抗酸菌研究会  2019.11 

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    Presentation type：Oral presentation (general)  

  • Klebsiella pneumoniae菌血症の30日後死亡予測因子の解析 ～遺伝子学的特徴も含めて～ Domestic conference

    並川 浩己, 仁木 誠, 仁木 満美子, 山田 康一, 中家 清隆, 榮山 新, 老沼 研一, 坪内 泰志, 金子 幸弘, 首藤 太一, 掛屋 弘

    第62回日本感染症学会中日本地方会学術集会  2019.11 

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    Presentation type：Oral presentation (general)  

    Venue：アクトシティ浜松  

  • Molecular characterization of Pseudomonas aeruginosa quorum sensing signal receptor RhlR Invited International conference

    Ken-Ichi Oinuma

    ERATO-MiCS International Symposium on Sociomicrobiology  2019.07 

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    Presentation type：Oral presentation (invited, special)  

    Venue：筑波大学 大学会館  

  • 緑膿菌クオラムセンシングシグナルレセプターRhlRの大腸菌による発現と解析 Domestic conference

    老沼 研一, 秦 大樹, 金子 幸弘

    第33回バイオフィルム学会学術集会  2019.07 

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    Presentation type：Oral presentation (general)  

    Venue：久留米大学 筑水会館  

  • Mycobacterium smegmatisが産生するhydrazidaseの発見と解析 Domestic conference

    栄山 新, 老沼 研一, 金子 幸弘

    日本農芸化学会2019年度大会  2019.03 

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    Presentation type：Oral presentation (general)  

    Venue：東京農業大学 世田谷キャンパス  

  • アシネトバクター属細菌の内因性因子によるカルバペネム耐性獲得機構の解析 Domestic conference

    榮山 新, 老沼 研一, 金子 幸弘

    第53回緑膿菌感染症研究会学術集会  2019.03 

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    Presentation type：Oral presentation (general)  

    Venue：秋田拠点センターALVE  

  • 当院で分離されたカルバペネム高度耐性Acinetobacter baumannii株のカルバペネマーゼ遺伝子の周辺構造と接合伝達性 Domestic conference

    老沼 研一, 鈴木 仁人, 佐伯 康匠, 坪内 泰志, 仁木 満美子, 山田 康一, 柴山 恵吾, 掛屋 弘, 金子 幸弘

    第53回緑膿菌感染症研究会学術集会  2019.03 

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    Presentation type：Oral presentation (general)  

    Venue：秋田拠点センターALVE  

  • hypermucoviscous Klebsiella pneumoniae感染症に対する新たなる治療戦略の確立にむけた基礎的研究 (第12回日本化学療法学会西日本支部 支部長賞(基礎部門) 受賞講演) Invited Domestic conference

    並川 浩己, 老沼 研一, 山入 和志, 柴多 渉, 山田 康一, 藤本 寛樹, 仁木 満美子, 金子 幸弘, 掛屋 弘

    第66回日本化学療法学会西日本支部総会  2018.11 

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    Presentation type：Oral presentation (invited, special)  

    Venue：かごしま県民交流センター  

  • hypermucoviscous Klebsiella pneumoniaeによる菌血症の臨床的特徴と予測因子の解析 Domestic conference

    並川 浩己, 榮山 新, 井本 和紀, 山入 和志, 柴多 渉, 吉井 直子, 山田 康一, 中家 清隆, 老沼 研一, 仁木 満美子, 坪内 泰志, 金子 幸弘, 首藤 太一, 掛屋 弘

    第61回日本感染症学会中日本地方会学術集会  2018.11 

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    Presentation type：Oral presentation (general)  

    Venue：かごしま県民交流センター  

  • protein RSA(Rhizopus-specific antigen)の機能解析 Domestic conference

    柴多 渉, 仁木 満美子, 老沼 研一, 井本 和紀, 山入 和志, 並川 浩己, 吉井 直子, 山田 康一, 金子 幸弘, 掛屋 弘

    第62回日本医真菌学会総会・学術集会  2018.09  (一社)日本医真菌学会

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    Presentation type：Poster presentation  

    Venue：東京都大手町サンケイプラザ  

  • hypermucoviscous Klebsiella pneumoniaeによる菌血症の臨床的特徴と予測因子の解析 Domestic conference

    並川 浩己, 榮山 新, 山内 健, 奥山 直木, 幕内 安弥子, 福本 一夫, 衣畑 成紀, 老沼 研一, 山田 康一, 豊田 宏光, 鎌田 紀子, 栩野 吉弘, 竹本 恭彦, 森村 美奈, 金子 幸弘, 掛屋 弘, 首藤 太一

    第17回日本病院総合診療医学会学術総会  2018.09  (一社)日本病院総合診療医学会

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    Presentation type：Oral presentation (general)  

    Venue：じゅうろくプラザ（岐阜市文化産業交流センター）  

  • 当院におけるAcinetobacter属細菌の分子疫学解析 Domestic conference

    老沼 研一

    第5回感染症科学研究センター研究セミナー  2018.07 

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    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：大阪市立大学 医学部学舎  

  • The development of new treatment strategy for hypermucoviscous Klebsiella pneumoniae infection with rifampicin as a candidate anti-mucoviscosity therapeutic agent International conference

    Namikawa H, Oinuma K, Sakiyama A, Yamada K, Kaneko Y, Kakeya H

    ASM Microbe 2018  2018.06  American Society for Microbiology

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    Presentation type：Poster presentation  

    Venue：Georgia World Congress Center  

  • 当院で分離されたカルバペネム高度耐性アシネトバクター株の耐性因子の特定と解析 Domestic conference

    老沼　研一, 鈴木　仁人, 佐藤　佳奈子, 佐伯　康匠, 中家　清隆, 滝沢　恵津子, 仁木　誠, 仁木　満美子, 山田　康一, 柴山　恵吾, 掛屋　弘, 金子　幸弘

    第52回緑膿菌感染症研究会学術集会  2018.02 

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    Presentation type：Oral presentation (general)  

    Venue：東北大学 星陵会館  

  • 散発事例でのAcinetobacter baumanniiにおけるPOT法とMLSTでの遺伝子型の相違 Domestic conference

    榮山　新, 老沼　研一, 鈴木　仁人, 佐藤　佳奈子, 佐伯　康匠, 中家　清隆, 滝沢　恵津子, 仁木　誠, 仁木　満美子, 山田　康一, 柴山　恵吾, 掛屋　弘, 金子　幸弘

    第52回緑膿菌感染症研究会学術集会  2018.02 

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    Presentation type：Oral presentation (general)  

    Venue：東北大学 星陵会館  

  • 高病原性Klebsiella pneumoniaeの粘性多糖の解析と抑制方法の開発 Domestic conference

    老沼 研一

    第8回醗酵学フォーラム  2017.11 

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    Presentation type：Oral presentation (general)  

    Venue：天童温泉「滝の湯」  

  • 微生物由来のヒドラジド加水分解酵素の探索と解析 Domestic conference

    榮山 新, 老沼 研一, 金子 幸弘

    第8回醗酵学フォーラム  2017.11 

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    Presentation type：Oral presentation (general)  

    Venue：天童温泉「滝の湯」  

  • NDM型とTMB型の2種のメタロ-β-ラクタマーゼを有するアシネトバクター属臨床分離株の発見と解析 Domestic conference

    老沼　研一, 鈴木　仁人, 佐藤　佳奈子, 佐伯　康匠, 中家　清隆, 滝沢　恵津子, 仁木　誠, 仁木　満美子, 山田　康一, 柴山　恵吾, 掛屋　弘, 金子　幸弘

    第87回日本感染症学会西日本地方会学術集会 第60回日本感染症学会中日本地方会学術集会 第65回日本化学療法学会西日本支部総会 合同学会  2017.10 

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    Presentation type：Oral presentation (general)  

    Venue：長崎ブリックホール  

  • hypermucoviscous Klebsiella pneumoniae感染症に対する新たなる治療戦略の確立にむけた基礎的研究 Domestic conference

    並川 浩己, 老沼 研一, 山入 和志, 柴多 渉, 山田 康一, 藤本 寛樹, 仁木 満美子, 金子 幸弘, 掛屋 弘

    第65回日本化学療法学会西日本支部総会  2017.10  (公社)日本化学療法学会

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    Presentation type：Oral presentation (general)  

    Venue：長崎ブリックホール  

  • 結核菌感染における液性免疫の役割 Domestic conference

    仁木　満美子, 星野　仁彦, 仁木　誠, 老沼　研一, 金子　幸弘

    第87回日本感染症学会西日本地方会学術集会 第60回日本感染症学会中日本地方会学術集会 第65回日本化学療法学会西日本支部総会 合同学会  2017.10 

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    Presentation type：Oral presentation (general)  

    Venue：長崎ブリックホール  

  • 血液由来Acinetobacter baumanniiのPOT法とMLSTによる遺伝子型の比較 Domestic conference

    榮山　新, 老沼　研一, 鈴木　仁人, 佐藤　佳奈子, 佐伯　康匠, 中家　清隆, 滝沢　恵津子, 仁木　誠, 仁木　満美子, 山田　康一, 柴山　恵吾, 掛屋　弘, 金子　幸弘

    第87回日本感染症学会西日本地方会学術集会 第60回日本感染症学会中日本地方会学術集会 第65回日本化学療法学会西日本支部総会 合同学会  2017.10 

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    Presentation type：Oral presentation (general)  

    Venue：長崎ブリックホール  

  • hypermucoviscous Klebsiella pneumoniae感染症に対する新たな治療法の確立に関する研究 Domestic conference

    並川　浩己, 老沼　研一, 山田　康一, 藤本　寛樹, 仁木　満美子, 竹本　恭彦, 金子　幸弘, 掛屋　弘, 首藤　太一

    第15回日本病院総合診療医学会学術総会  2017.09 

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    Presentation type：Oral presentation (general)  

    Venue：ディズニーアンバサダーホテル  

  • ゲノム情報に基づくアシネトバクター属臨床分離株の分子疫学解析 Domestic conference

    老沼　研一, 鈴木　仁人, 佐藤　佳奈子, 中家　清隆, 滝沢　恵津子, 仁木　誠, 仁木　満美子, 山田　康一, 柴山　恵吾, 掛屋　弘, 金子　幸弘

    第91回日本感染症学会総会・学術講演会 第65回日本化学療法学会学術集会 合同学会  2017.04 

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    Presentation type：Oral presentation (general)  

    Venue：京王プラザホテル  

  • Enterococcus faecalisとEnterococcus faeciumによる菌血症の比較検討 Domestic conference

    並川　浩己, 山田　康一, 柴多　渉, 藤本　寛樹, 中家　清隆, 滝沢　恵津子, 中村　安孝, 安倍　順子, 岡田　恵代, 藤田　明子, 老沼　研一, 仁木　満美子, 金子　幸弘, 首藤　太一, 掛屋　弘

    第91回日本感染症学会総会・学術講演会 第65回日本化学療法学会学術集会 合同学会  2017.04 

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    Presentation type：Poster presentation  

    Venue：京王プラザホテル  

  • Rhizopus属特異的抗原の診断への応用～マウスモデルを用いた検討 Domestic conference

    佐藤　佳奈子, 金子　幸弘, 老沼　研一, 仁木　満美子, 山田　康一, 山越　智, 宮崎　義継, 掛屋　弘

    第91回日本感染症学会総会・学術講演会 第65回日本化学療法学会学術集会 合同学会  2017.04 

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    Presentation type：Oral presentation (general)  

    Venue：京王プラザホテル  

  • POT法およびMLST法によるアシネトバクター属臨床分離株の遺伝子型解析 Domestic conference

    老沼 研一, 鈴木 仁人, 佐藤 佳奈子, 中家 清隆, 滝沢 恵津子, 仁木 誠, 仁木 満美子, 山田 康一, 柴山 恵吾, 掛屋 弘, 金子 幸弘

    第51回緑膿菌感染症研究会学術集会  2017.02  緑膿菌感染症研究会

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    Presentation type：Oral presentation (general)  

    Venue：レンブラントホテル大分  

  • 当院で血液培養より分離されたアシネトバクター属細菌の分子疫学解析 Domestic conference

    金子 幸弘, 老沼 研一, 佐藤 佳奈子, 鈴木 仁人, 柴山 恵吾, 滝沢 恵津子, 仁木 誠, 中家 清隆, 仁木 満美子, 山田 康一, 掛屋 弘

    第28回日本臨床微生物学会総会・学術集会  2017.01  (一社)日本臨床微生物学会

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    Presentation type：Oral presentation (general)  

    Venue：長崎ブリックホール, 長崎新聞文化ホール, 長崎県医師会館  

  • アシネトバクター属臨床分離株の薬剤感受性試験と分子疫学解析 Domestic conference

    老沼 研一, 佐藤 佳奈子, 鈴木 仁人, 柴山 恵吾, 滝沢 恵津子, 仁木 誠, 中家 清隆, 仁木 満美子, 山田 康一, 掛屋 弘, 金子 幸弘

    第59回日本感染症学会中日本地方会学術集会  2016.11  (一社)日本感染症学会

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    Presentation type：Oral presentation (general)  

    Venue：沖縄コンベンションセンター, カルチャーリゾートフェストーネ  

  • マウスモデルを用いた侵襲性肺ムーコル症に対する新規診断系の検討 Domestic conference

    金子 幸弘, 佐藤 佳奈子, 老沼 研一, 仁木 満美子, 山田 康一, 山越 智, 宮﨑 義継, 掛屋 弘

    第59回日本感染症学会中日本地方会学術集会  2016.11 

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    Presentation type：Oral presentation (general)  

    Venue：沖縄コンベンションセンター, カルチャーリゾートフェストーネ  

  • Aspergillus calidoustus重複感染が確認されたLichtheimia ramosaによる消化管型ムーコル症の一例 Domestic conference

    水谷 哲, 老沼 研一, 寺地 つね子, 掛屋 弘, 金子 幸弘

    第60回日本医真菌学会総会・学術集会  2016.10  (一社)日本医真菌学会

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    Presentation type：Poster presentation  

    Venue：東京都立産業貿易センター 台東館  

  • 侵襲性肺ムーコル症マウスモデルにおけるRhizopus oryzae特異的分泌抗原の有用性の検討 Domestic conference

    佐藤 佳奈子, 老沼 研一, 山田 康一, 掛屋 弘, 金子 幸弘

    第60回日本医真菌学会総会・学術集会  2016.10  (一社)日本医真菌学会

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    Presentation type：Poster presentation  

    Venue：東京都立産業貿易センター 台東館  

  • 遺伝子組換え大腸菌を用いたフェニル乳酸生産に影響を与える遺伝子の発現解析 Domestic conference

    宮川 寛規, 川口 秀夫, 荻野 千秋, 老沼 研一, 高谷 直樹, 近藤 昭彦

    第68回日本生物工学会大会  2016.09 

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    Presentation type：Poster presentation  

    Venue：富山国際会議場, ANAクラウンプラザホテル富山  

  • Discovery and analysis of a novel Rhizopus antigen as a potential diagnostic marker for mucormycosis Invited International conference

    Oinuma K, Sato K, Niki M, Kakeya H, Kaneko Y

    2016 International Symposium on New Frontiers in Microbiology and Biotechnology  2016.07 

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    Presentation type：Oral presentation (general)  

    Venue：筑波大学  

  • 血液由来Acinetobacter属細菌の薬剤感受性試験と菌種同定 Domestic conference

    老沼 研一, 佐藤 佳奈子, 滝沢 恵津子, 仁木 誠, 中家 清隆, 並川 浩己, 藤本 寛樹, 仁木 満美子, 山田 康一, 掛屋 弘, 金子 幸弘

    第50回緑膿菌感染症研究会学術集会  2016.02  緑膿菌感染症研究会

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    Presentation type：Oral presentation (general)  

    Venue：ヒルトン東京お台場  

  • Aspergillus niger由来芳香族ポリエステル分解酵素の発見と解析 Domestic conference

    老沼 研一, 金子 達雄, 高谷 直樹

    日本農芸化学会2015年度大会  2015.03 

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    Presentation type：Oral presentation (general)  

    Venue：ホテルグランヴィア岡山, 岡山大学 津島キャンパス  

  • Microbacterium sp.におけるヒドラジド代謝遺伝子の解析 Domestic conference

    秋山 友了, 多久和 篤史, 石毛 太一郎, 佐々木 康幸, 伊藤 晋作, 老沼 研一, 高谷 直樹, 矢嶋 俊介

    日本農芸化学会2015年度大会  2015.03 

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    Presentation type：Oral presentation (general)  

    Venue：ホテルグランヴィア岡山, 岡山大学 津島キャンパス  

  • Streptomyces属放線菌が産生する菌体外ジアホラーゼの解析 Domestic conference

    老沼 研一, 進藤 大騎, 高野 英晃, 高谷 直樹, 上田 賢志

    日本農芸化学会2015年度大会  2015.03 

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    Presentation type：Oral presentation (general)  

    Venue：ホテルグランヴィア岡山, 岡山大学 津島キャンパス  

  • Development of fermentation production systems for useful aromatic compounds Invited International conference

    Oinuma K, Masuo S, Shigemoto R, Takaya N

    2015 International Symposium on New Frontiers in Microbiology and Biotechnology  2015.01 

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    Presentation type：Oral presentation (general)  

    Venue：江南大学（無錫市, 中国）  

  • バイオマス糖化液由来成分が大腸菌のフェニル乳酸発酵に与える影響 Domestic conference

    川口 秀夫, 寺村 浩, 中村 聡子, 荻野 千秋, 原 清敬, 蓮沼 誠久, 老沼 研一, 高谷 直樹, 平野 恒, 佐塚 隆志, 北野 英己, 近藤 昭彦

    第66回日本生物工学会大会  2014.09  (公社)日本生物工学会

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    Presentation type：Poster presentation  

    Venue：札幌コンベンションセンター  

  • Development of fermentation systems for useful aromatic compounds International conference

    Oinuma K

    Kickoff Symposium for Tsukuba-Norwich Collaborative Research Networks  2014.03 

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    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：筑波大学  

  • 同時糖化発酵によるセルロースからのフェニル乳酸生産 Domestic conference

    川口 秀夫, 中村 聡子, 荻野 千秋, 老沼 研一, 高谷 直樹, 近藤 昭彦

    第65回日本生物工学会大会  2013.09  (公社)日本生物工学会

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    Presentation type：Poster presentation  

    Venue：広島国際会議場  

  • Degradation and adsorption of soil humic acids by various fungal species Domestic conference

    2013.03 

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    Presentation type：Oral presentation (general)  

  • Biochemical and structural analyses of bacterial quorum-sensing signal receptors Invited International conference

    Oinuma K, Greenberg EP

    2013 International Symposium on New Frontiers in Microbiology and Biotechnology  2013.03 

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    Presentation type：Oral presentation (general)  

    Venue：江南大学（無錫市, 中国）  

  • 糸状菌の代謝を活用したバイオマス材料 Invited Domestic conference

    老沼 研一

    プレ戦略イニシアティブ「生物機能の高度利用を目指した応用微生物学研究拠点」シンポジウム  2012.12 

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    Presentation type：Oral presentation (invited, special)  

    Venue：筑波大学  

  • バイオマス利活用に向けた組換えバイオマスの栽培・利用の技術開発 Domestic conference

    小口 太一, 老沼 研一, 高谷 直樹, 渡邉 和男, 江面 浩

    NC-CARP公開キックオフシンポジウム  2012.05 

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    Presentation type：Poster presentation  

    Venue：東京大学 弥生講堂一条ホール  

  • Investigation of acyl-homoserine lactone binding to and stability of the Pseudomonas aeruginosa quorum-sensing signal receptor, QscR Domestic conference

    2010.12 

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    Presentation type：Poster presentation  

  • 緑膿菌Quorum sensing の分子メカニズム Invited Domestic conference

    老沼 研一

    特別講演会  2010.11  徳島大学歯学部

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    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：徳島大学歯学部  

  • 緑膿菌Pseudomonas aeruginosaの集団行動～クオラムセンシング機構の新たな側面 Invited Domestic conference

    老沼 研一

    特別講演  2010.11  日本大学生物資源科学部

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    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：日本大学生物資源科学部  

  • Biochemical analysis of QscR, an orphan quorum-sensing signal receptor in Pseudomonas aeruginosa Invited Domestic conference

    老沼 研一

    特別講演  2010.11  筑波大学大学院生命環境科学研究科

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    Presentation type：Public lecture, seminar, tutorial, course, or other speech  

    Venue：筑波大学  

  • Investigation of the Pseudomonas aeruginosa quorum-sensing regulator, QscR, leads to a new model of how acyl-homoserine lactone receptors are synthesized International conference

    Oinuma K, Greenberg EP

    The 24th Annual North American Cystic Fibrosis Conference  2010.10 

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    Presentation type：Poster presentation  

    Venue：Baltimore Convention Center (Baltimore, Maryland, USA)  

  • Analysis of the reaction mechanism of aliphatic aldoxime dehydratase from the industrial strain, Pseudomonas chlororaphis B23 International conference

    Oinuma K, Konishi K, Ohta T, Kumita H, Hashimoto Y, Shiro Y, Kitagawa T, Kobayashi M

    第9回日中韓酵素工学会議  2006.10 

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    Presentation type：Oral presentation (general)  

    Venue：ピアザ淡海  

  • Analysis of the reaction mechanism of aldoxime dehydratase containing heme as the active center International conference

    Oinuma K, Kumita H, Ohta T, Konishi K, Ishida K, Hashimoto Y, Higashibata H, Kitagawa T, Shiro Y, Kobayashi M

    30th FEBS Congress & 9th IUBMB Conference  2005.07  Federation of European Biochemical Societies, International Union of Biochemistry and Molecular Biology

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    Presentation type：Poster presentation  

    Venue：Budapest, Hungary  

  • Overall nitrile pathway in the industrial Pseudomonas chlororaphis B23 International conference

    Hashimoto Y, Hosaka H, Oinuma K, Goda M, Higashibata H, Kobayashi M

    30th FEBS Congress & 9th IUBMB Conference  2005.07  Federation of European Biochemical Societies, International Union of Biochemistry and Molecular Biology

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    Presentation type：Poster presentation  

    Venue：Budapest, Hungary  

  • Heme environment in aldoxime dehydratase involved in nitrile synthesis International conference

    Oinuma K, Ohta T, Konishi K, Hashimoto Y, Higashibata H, Kitagawa T, Kobayashi M

    ASBMB Annual Meeting and 8th IUBMB Conference  2004.06 

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    Presentation type：Poster presentation  

    Venue：Hynes Convention Center, Boston, USA  

  • Nitrile pathway involving Acyl-CoA synthetase in the industrial microorganism International conference

    Hosaka H, Hashimoto Y, Oinuma K, Goda M, Higashibata H, Kobayashi M

    ASBMB Annual Meeting and 8th IUBMB Conference  2004.06 

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    Presentation type：Poster presentation  

    Venue：Hynes Convention Center, Boston, USA  

  • Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of the industrial Pseudomonas chlororaphis B23 International conference

    Oinuma K, Hashimoto Y, Konishi K, Goda M, Higashibata H, Kobayashi M

    103rd General Meeting of the American Society for Microbiology  2003.05 

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    Presentation type：Poster presentation  

    Venue：Washington Convention Center (Washington, D.C., USA)  

▼display all

Grant-in-Aid for Scientific Research

  • 緑膿菌の病原性抑制薬の開発に向けたクオラムセンシング制御機構の基盤研究

    Grant-in-Aid for Scientific Research(C)  2022

  • 緑膿菌クオラムセンシング機構の総体的理解に向けたAHLレセプターの機能解析

    Grant-in-Aid for Young Scientists(B)  2017.04

  • 薬剤耐性アシネトバクターのゲノム疫学解析による耐性機構の解明

    Grant-in-Aid for Scientific Research(C)  2017.04

  • 芳香族主鎖型ポリマー加水分解酵素の探索と機能解析

    Grant-in-Aid for Young Scientists(B)  2014.04

  • ニトリル代謝系の分子機能解析

    Grant-in-Aid for JSPS Fellows  2005.04

Incentive donations / subsidies

  • 結核菌類縁種由来ヒドラジド分解酵素の同定と解析

    公益財団法人野田産業科学研究所  2018.04

Other subsidies, etc.

  • 緑膿菌のクオラムセンシング制御因子RhlRの分子機能解析

    大学  2017.04

Outline of education staff

  • 1) 医学部学生に対する講義・実習
    　大阪市立（公立）大学医学部医学科2,3回生を対象とした「細菌・真菌感染症」において、「インフルエンザ菌」、「緑膿菌とアシネトバクター」、「梅毒と淋菌およびクラミジア感染症」の講義（計3コマ）を受け持つとともに、教授、准教授らと共同で実習を担当している。また、1回生を対象とした医学研究推進コース1では、例年2～3名の学生のレポート評価を担当しており、3回生を対象とした医学研究推進コース3では、2～3名の学生を約3か月間教室で預かり研究指導を行っている。

    2) 大学院生に対する講義・実習
    　大阪市立（公立）大学大学院医学研究科（博士課程および修士課程）の専門科目である「細菌学セミナー」、「細菌学研究演習」、「細菌学実習」、「研究指導」、「発表表現演習」、「都市医学」（いずれもオムニバス方式（一部共同））を他教員と分担で受け持っている。また、共通科目である病理病態学概論において、細菌の病原因子に関する講義を担当している（1コマ）。

    3) 大学院生に対する研究指導
    　細菌学教室所属の大学院生に対し、研究計画の立案、分子生物学的実験手技、実験データの解釈、報告書・論文の作成等に関する指導を行っている。

Charge of on-campus class subject

  • 人体を考える

    2023   Weekly class   Undergraduate

  • 医学研究推進コース3

    2023   Practical Training   Undergraduate

  • 病理病態学概論

    2023     Graduate school

  • 都市医学（細菌学）

    2023     Graduate school

  • 発表表現演習（細菌学）

    2023     Graduate school

  • 研究指導

    2023     Graduate school

  • 細菌学実習

    2023   Practical Training   Graduate school

  • 細菌学研究演習

    2023     Graduate school

  • 細菌学セミナー

    2023     Graduate school

  • 細菌・真菌感染症

    2023     Undergraduate

  • 病理病態学概論

    2022     Graduate school

  • 都市医学（細菌学）

    2022     Graduate school

  • 発表表現演習（細菌学）

    2022     Graduate school

  • 研究指導

    2022     Graduate school

  • 細菌学実習

    2022   Practical Training   Graduate school

  • 細菌学研究演習

    2022     Graduate school

  • 細菌学セミナー

    2022     Graduate school

  • 細菌・真菌感染症

    2022     Undergraduate

  • 医学研究推進コース3

    2022   Practical Training   Undergraduate

  • 修業実習

    2021   Practical Training   Undergraduate

  • 病理病態学概論

    2021     Graduate school

  • 都市医学（細菌学）

    2021     Graduate school

  • 発表表現演習（細菌学）

    2021     Graduate school

  • 研究指導

    2021     Graduate school

  • 細菌学実習

    2021   Practical Training   Graduate school

  • 細菌学研究演習

    2021     Graduate school

  • 細菌学セミナー

    2021     Graduate school

  • 細菌・真菌感染症コース

    2021     Undergraduate

  • 環境と健康

    2020     Undergraduate

  • 修業実習

    2020     Undergraduate

  • 細菌・真菌感染症コース (M2)

    2020     Undergraduate

  • 細菌・真菌感染症コース (M3)

    2020     Undergraduate

  • 細菌学セミナー

    2020     Graduate school

  • 細菌学研究演習

    2020     Graduate school

  • 細菌学実習

    2020     Graduate school

  • 研究指導

    2020     Graduate school

  • 発表表現演習

    2020     Graduate school

  • 都市医学

    2020     Graduate school

  • 病理病態学概論

    2020     Graduate school

  • 病理病態学概論

    2019     Graduate school

  • 都市医学

    2019     Graduate school

  • 発表表現演習

    2019     Graduate school

  • 研究指導

    2019     Graduate school

  • 細菌学実習

    2019     Graduate school

  • 細菌学研究演習

    2019     Graduate school

  • 細菌学セミナー

    2019     Graduate school

  • 細菌・真菌感染症コース (M3)

    2019     Undergraduate

  • 細菌・真菌感染症コース (M2)

    2019     Undergraduate

  • 修業実習

    2019     Undergraduate

  • 細菌・真菌感染症コース (M3)

    2018     Undergraduate

  • 細菌学実習

    2018     Graduate school

  • 感染制御セミナー

    2018     Graduate school

  • 細菌学研究演習

    2018     Graduate school

  • 細菌学セミナー

    2018     Graduate school

  • 修業実習

    2018     Undergraduate

  • 細菌・真菌感染症コース (M2)

    2018     Undergraduate

  • 修業実習

    2017     Undergraduate

  • 病理病態学概論

    2017     Graduate school

  • 細菌・真菌感染症コース (M2)

    2017     Undergraduate

  • 細菌・真菌感染症コース (M3)

    2017     Undergraduate

▼display all

Charge of off-campus class subject

  • 細胞分子機能科学特論II

    2021.11
    -
    Now
    Institution：Tokyo University of Agriculture

    　More details

    Level：Postgraduate 

  • 生化学実験

    2017.09
    -
    Now
    Institution：Tezukayama University

    　More details

    Level：Undergraduate (specialized) 

Faculty development activities

  • FD活動への貢献  2023

    　More details

    教育能力の向上のため、本学医学部が主催する教育分野FD講演会に参加した（4回）。

  • FD活動への貢献  2022

    　More details

    教育能力の向上のため、本学医学部が主催する教育分野FD講演会に参加した（4回）。

  • FD活動への貢献  2021

    　More details

    教育能力の向上のため、本学医学部が主催する教育分野FD講演会に参加した（4回）。また、第7回 教育分野FDワークショップに受講者として参加した。

  • FD活動への貢献  2020

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    教育分野FD講演会に参加（1回）

  • FD活動への貢献  2019

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    教育分野FD講演会に参加（1回）

  • FD活動への貢献  2018

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    教育分野FD講演会に参加（1回）

  • FD活動への貢献  2017

    　More details

    教育分野FD講習会に参加（1回）

▼display all

Original item・Special report (Education Activity)

  • 2023

    　 More details

    Original item：リゾーム型研究人材育成プログラム（国立研究開発法人 科学技術振興機構 次世代研究者挑戦的研究プログラム [事業統括: 大阪公立大学 社会連携担当副学長 重松 孝昌教授]）において、細菌学教室に所属する1名の大学院生（博士課程）に対し、指導教員として研究指導と資格審査を行った。

  • 2022

    　 More details

    Original item：リゾーム型研究人材育成プログラム（国立研究開発法人 科学技術振興機構 次世代研究者挑戦的研究プログラム [事業統括: 大阪公立大学 社会連携担当副学長 重松 孝昌教授]）において、細菌学教室に所属する2名の大学院生（博士課程2名）に対し、指導教員として研究指導と資格審査を行った。

  • 2021

    　 More details

    Original item：リゾーム型研究人材育成プログラム（国立研究開発法人 科学技術振興機構 次世代研究者挑戦的研究プログラム [事業統括: 大阪公立大学 社会連携担当副学長 重松 孝昌教授]）において、細菌学教室に所属する2名の大学院生（博士課程2名）に対し、指導教員として研究指導と資格審査を行った。

Other

  • Job Career

    2021.04 - Now

  • Job Career

    2015.04 - 2021.03