Researcher Profiles - KAKEHASHI Anna

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KAKEHASHI Anna

Organization

Graduate School of Medicine Department of Basic Medical Science Associate Professor
School of Medicine Department of Medical Science

Affiliation

Institute of Medcine

Homepage

http://www.med.osaka-cu.ac.jp/pathology/

Other name(s)

KINOSHITA ANNA

Profile

Anna Kakehashi had entered Osaka City University Graduated School of Medicine in April, 1999 and graduated with PhD D.M.Sc. Degree in March, 2003. Thereafter, she was employed at the Department of Molecular Pathology, Osaka Metropolitan University (former Osaka City University) Graduate School of Medicine as a Research Resident, in 2007 became the Research Associate, in 2013 Lecturer, and in July 2023 Associate Professor at the Department of Molecular Pathology. Her research belongs to the field of experimental, molecular pathology and chemical carcinogenesis, mostly devoted to the investigation of mechanisms of carcinogenesis, cancer risk assessment, early detection, prevention, and treatment of cancer. The recent research is focused on virus and metabolic dysfunction-associated steatohepatitis (MASH)-related and pancreatic carcinogenesis, development of new cancer and cancer stem cell markers. In respect with internation research, her work on the risk assessment of Bioethanol (ETBE) was highly evaluated by Environmetal Protection Agency (US EPA). Furthermore, from 2020 with Chiang Mai University, School of Medicine, Thailand. Osaka Metropolitan University has received an agreement exchange subsidy project (researcher dispatch) with overseas universities.

Affiliation campus

Abeno Campus

Position

Graduate School of Medicine Department of Basic Medical Science

Associate Professor 2023.07 - Now
Graduate School of Medicine Department of Basic Medical Science

Lecturer 2013.04 - 2023.06
School of Medicine Department of Medical Science

Assistant Professor 2006.07 - 2013.03
School of Medicine Department of Medical Science Japan Society for the Promotion of Science

Research Fellow 2006.04 - 2006.06
School of Medicine Department of Medical Science Ministry of Health, Labor and Welfare Subsidy Young Researcher Development and Utilization Project

Research resident 2003.12 - 2006.03

Degree

Doctor of Medical Science （ Osaka City University ）
Master of Science （ Others ） ( Saint-Petersburg State University )

Research Areas

Life Science / Experimental pathology / molecular pathology, chemical carcinogenesis, cancer diagnosis,・treatment・prevention, MASH, oxidative stress, DNA damage and repair

Research Interests

Molecular Pathology
Chemical Carcinogenesis
Translational Research
Cancer Risk Assessment
Cancer biomarkers and molecular targets
Oxidative stress-DNA damage-DNA repair
Cancer Prevention
MAFLD/MASH
PDAC
Hepatocellular carcinoma

Research subject summary

Investigation of mechanisms of carcinogenesis: biochemical and molecular-biological analyses.
Investigation of biomarkers and mechanisms of virus and NASH-associated liver cancer, and invasive pancreatic ductal carcinoma.
Analysis of the proteome, metabolome alterations and biological markers in carcinogenesis.
Oxidative stress, DNA damage and repair in carcinogenesis.
Risk assessment of chemical carcinogens.
Cancer Prevention.

Research Career

浸潤性膵管がんの早期発見バイオ―マーカー及び発がん機序解明

2020.04 - Now
Analysis of mechanisms of NASH-associated carcinogenesis and detection of biomarkers

NASH, liver cancer, mechanism, biomarker Individual

2017.04 - Now
Study on mechanisms of carcinogenesis: Biochemical and molecular-biological approach

Chemical carcinogenesis, Molecular pathology, Biochemistry Individual

2003.04 - Now
Translational research in investigation of cancer mechanisms and novel biomarkers

Liver cancer, pancreas cancer, lung cancer, biomarker, molecular targets, translational research Individual

2003.04 - Now
Cancer chemoprevention

Cancer prevention, Chemoprevention Individual

2003.04 - Now
Oxidative stress DNA damage and repair in carcinogenesis

Individual

2000.04 - Now
Cancer risk assessment for genotoxic and non-genotoxic carcinogens

Cancer risk assessment, Toxicologic pathology, Molecular pathology Individual

1999.04 - Now
Study on molecular mechanisms of arsenic carcinogenicity

arsenic, carcinogenesis, mechanism International Joint Research

1999.04 - Now

Professional Memberships

Japanese Association for Cancer Research

Domestic
Japanese Society for Carcinogenic Pathology

Domestic
Society of Toxicology (USA)

Overseas
Japanese Food and Chemical Association

Domestic
Japanese Toxicology Association

Domestic
Japanese Association for Cancer Prevention

Domestic
Japanese Toxicologic Pathology Association

Domestic
Japanese Pathology Association

Domestic

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Awards

高松宮妃癌研究基金学術省

梯アンナ

2022.04 公益財団法人浸潤性膵管癌の早期発見や治療のための新規バイオーマーカーおよび分子ターゲットの解明

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Country：Japan
弟8回大阪市立大学女性研究者特別賞[岡村賞]

梯アンナ

2021.12 大阪市立大学

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Country：Japan
Osaka City Medical Association President Award 2017

Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Masaki Fujioka, Min Wei, Shoji Fukushima, Hideki Wanibuchi

2018.03 Osaka City Medical Association Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital

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Country：Japan
Dean Award of Excellence 2017

2018.03 Osaka City University Graduate School of Medicine Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital Journal: Oxidative Medicine and Cellular Longevity

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Country：Japan
Award for young scientists from Society of Toxicology of Japan

Anna Kakehashi

2003.07 JTA Carcinogenicity of low doses of phenobarbital in the rat liver: Evidence for hormesis

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Country：Japan
Award from the Chairman of Society of Toxicologic Pathology of Japan

Phenobarbital at low dose suppresses rat hepatocarcinogenesis by altering cellproliferation, apoptosis and inhibiting oxidative DNA damage

2002.01 JSTP

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Country：Japan

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Education

Osaka City University Chemical carcinogenesis Cancer risk assessment Mol.pathology Doctor's Course Graduated/Completed

1999 - 2003

Papers

Metabolism and effects of acetoaceto-o-toluidine in the urinary bladder of humanized-liver mice Invited

Suzuki Shugo, Gi Min, Yanagiba Yukie, Yoneda Nao, Uehara Shotaro, Yokota Yuka, Noura Ikue, Fujioka Masaki, Vachiraarunwong Arpamas, Kakehashi Anna, Koda Shigeki, Suemizu Hiroshi, Wanibuchi Hideki

Journal of Toxicologic Pathology 38 ( 1 ) 59 - 67 2025.01（ ISSN:0914-9198 ）（ eISSN:1881915X ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

 Occupational exposure to aromatic amines is a major risk factor for urinary bladder cancer. Our previous studies showed that acetoaceto-o-toluidine, which is produced using o-toluidine as a raw material, promotes urinary bladder carcinogenesis in rats. We also found high concentrations of o-toluidine, a human bladder carcinogen, in the urine of acetoaceto-o-toluidine-treated rats, indicating that urinary o-toluidine derived from acetoaceto-o-toluidine may play an important role in bladder carcinogenesis. However, this has not been investigated in humans. In the present study, we used non-humanized (F1-TKm30 mice) and humanized-liver mice established by human hepatocyte transplantation to compare differences in urinary acetoaceto-o-toluidine metabolites produced by human and mouse liver cells. We also examined the changes in acetoaceto-o-toluidine-induced mRNA expression in the liver and the proliferative effects on the bladder epithelium. Urinary o-toluidine was detected in both non-humanized and humanized mice. Acetoaceto-o-toluidine metabolites in the urine, cell proliferation activities, and DNA damage in the bladder urothelium were similar in non-humanized and humanized-liver mice. RNA expression analysis revealed that CYP1A2 expression increased in the livers of humanized-liver mice, and Cyp2c29 expression (equivalent to human CYP2C9/19) increased in the livers of non-humanized mice. These data suggest that acetoaceto-o-toluidine may be a human carcinogen, as evidenced by the detection of urinary o-toluidine in acetoaceto-o-toluidine-treated humanized-liver mice. This animal model is important for extrapolating toxicity data from animals to humans.

DOI： 10.1293/tox.2024-0042

PubMed
Urinary bladder carcinogenic potential of 4,4'-methylenebis(2-chloroaniline) in humanized-liver mice. Reviewed

Shugo Suzuki, Min Gi, Takuma Kobayashi, Noriyuki Miyoshi, Nao Yoneda, Shotaro Uehara, Yuka Yokota, Ikue Noura, Masaki Fujioka, Arpamas Vachiraarunwong, Anna Kakehashi, Hiroshi Suemizu, Hideki Wanibuchi

Toxicological Sciences : an official journal of the Society of Toxicology 202 ( 2 ) 210 - 219 2024.12（ ISSN:10966080 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Occupational exposure to 4,4'-methylenebis(2-chloroaniline) (MOCA) has been linked to an increased risk of bladder cancer among employees in Japanese plants, indicating its significance as a risk factor for urinary bladder cancer. To investigate the role of MOCA metabolism in bladder carcinogenesis, we administered MOCA to non-humanized (F1-TKm30 mice) and humanized-liver mice for 4 and 28 wk. We compared MOCA-induced changes in metabolic enzyme expression, metabolite formation, and effects on the urinary bladder epithelium in the 2 models. At week 4, MOCA exposure induced simple hyperplasia, cell proliferation, and DNA damage in the urothelium of the humanized-liver mice, whereas in the non-humanized mice, these effects were not observed. Notably, the concentration of 4-amino-4'-hydroxylamino-3,3'-dichlorodiphenylmethane (N-OH-MOCA) in the urine of humanized-liver mice was more than 10 times higher than that in non-humanized mice at the 4-wk mark. Additionally, we observed distinct differences in the expression of cytochrome P450 isoforms between the 2 models. Although no bladder tumors were detected after 28 wk of treatment in either group, these findings suggest that N-OH-MOCA significantly contributes to the carcinogenic potential of MOCA in humans.

DOI： 10.1093/toxsci/kfae119

PubMed
Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long-term study after 2-week intra-tracheal intrapulmonary administration. Reviewed

Sheema AN, Naiki-Ito A, Kakehashi A, Ahmed OHM, Alexander DB, Alexander WT, Numano T, Kato H, Goto Y, Takase H, Hirose A, Wakahara T, Miyazawa K, Takahashi S, Tsuda H

Archives of Toxicology 98 ( 12 ) 4143 - 4158 2024.12（ ISSN:0340-5761 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

DOI： 10.1007/s00204-024-03863-7

PubMed
Characterizing the toxicological responses to inorganic arsenicals and their metabolites in immortalized human bladder epithelial cells. Reviewed

Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Runjie Guo, Tomoki Yamamoto, Anna Kakehashi, Masayuki Shiota, Hideki Wanibuchi

Archives of toxicology 98 ( 7 ) 2065 - 2084 2024.07（ ISSN:0340-5761 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Arsenic is highly toxic to the human bladder. In the present study, we established a human bladder epithelial cell line that closely mimics normal human bladder epithelial cells by immortalizing primary uroplakin 1B-positive human bladder epithelial cells with human telomerase reverse transcriptase (HBladEC-T). The uroplakin 1B-positive human bladder epithelial cell line was then used to evaluate the toxicity of seven arsenicals (iAsV, iAsIII, MMAV, MMAIII, DMAV, DMAIII, and DMMTAV). The cellular uptake and metabolism of each arsenical was different. Trivalent arsenicals and DMMTAV exhibited higher cellular uptake than pentavalent arsenicals. Except for MMAV, arsenicals were transported into cells by aquaglyceroporin 9 (AQP9). In addition to AQP9, DMAIII and DMMTAV were also taken up by glucose transporter 5. Microarray analysis demonstrated that arsenical treatment commonly activated the NRF2-mediated oxidative stress response pathway. ROS production increased with all arsenicals, except for MMAV. The activating transcription factor 3 (ATF3) was commonly upregulated in response to oxidative stress in HBladEC-T cells: ATF3 is an important regulator of necroptosis, which is crucial in arsenical-induced bladder carcinogenesis. Inorganic arsenics induced apoptosis while MMAV and DMAIII induced necroptosis. MMAIII, DMAV, and DMMTAV induced both cell death pathways. In summary, MMAIII exhibited the strongest cytotoxicity, followed by DMMTAV, iAsIII, DMAIII, iAsV, DMAV, and MMAV. The cytotoxicity of the tested arsenicals on HBladEC-T cells correlated with their cellular uptake and ROS generation. The ROS/NRF2/ATF3/CHOP signaling pathway emerged as a common mechanism mediating the cytotoxicity and carcinogenicity of arsenicals in HBladEC-T cells.

DOI： 10.1007/s00204-024-03750-1

PubMed
Elucidation of anticancer effects of Propolis Reviewed

Kakehashi, A.

115 ３ - ３ 2024.04
Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma Reviewed

Tagami M, Kasashima H, Kakehashi A, Yoshikawa A, Nishio M, Misawa N, Sakai A, Wanibuchi H, Yashiro M, Azumi A, Honda S

Frontiers in Oncology 14 1277749 2024.01（ ISSN:2234-943X ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

DOI： 10.3389/fonc.2024.1277749

PubMed
Nicotine promotes the development of invasive bladder carcinoma in rats

FUJIOKA Masaki, SUZUKI Shugo, GI Min, NOURA Ikue, VACHIRAARUNWONG Arpamas, KAKEHASHI Anna, WANIBUCHI Hideki

Journal of Toxicologic Pathology advpub ( 0 ) 2024（ ISSN:09149198 ）（ eISSN:1881915X ）

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Publishing type：Research paper (scientific journal)

Tobacco smoking is a major risk factor for human cancers including urinary bladder carcinoma. In a previous study, nicotine was shown to enhance rat urinary bladder carcinogenesis in a two-stage carcinogenesis model. In this study, we examined the progressive effects of nicotine on bladder carcinogenesis in F344 rats treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). Nicotine, administered in drinking water for 52 weeks following 4 weeks of BBN treatment, significantly increased the incidence and multiplicity of invasive urothelial carcinoma in a dose-dependent manner. The Ki67 labeling index of bladder papillomas was significantly increased by nicotine in a dose-dependent manner. However, nicotine treatment did not affect the incidence or total number of tumors, and nicotine administration alone for 52 weeks did not result in any neoplastic lesions. These data suggest that while nicotine does not initiate carcinogenesis, it has the potential to promote invasive urinary cancers.

DOI： 10.1293/tox.2024-0087
Comparative analysis of the toxic effects on the mouse lung of 4 weeks exposure to the heated tobacco product Ploom TECH+ and 3R4F reference cigarettes

NOURA Ikue, SUZUKI Shugo, GI Min, FUJIOKA Masaki, MATSUE Taisuke, KAKEHASHI Anna, WANIBUCHI Hideki

Journal of Toxicologic Pathology advpub ( 0 ) 2024（ ISSN:09149198 ）（ eISSN:1881915X ）

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Publishing type：Research paper (scientific journal)

Pulmonary emphysema is primarily attributable to prolonged exposure to cigarette smoke. Novel tobacco substitutes, such as heated tobacco products, have emerged as healthier alternatives to cigarettes. The effects of short-term inhalation of a heated tobacco product, Ploom TECH+ (PT+), on the lungs of mice were compared with those of 3R4F reference cigarettes. Male 10-week-old C57BL mice were exposed to clean air (control), 3R4F, or PT+ for 1 h/d, 5 d/week for two or four weeks. After four weeks of exposure, the number of inflammatory cells and proportion of neutrophils and lymphocytes in the bronchoalveolar lavage fluid and the number of macrophages in the lung tissue increased significantly in mice exposed to 3R4F but not in those exposed to PT+. Changes in the expression of genes related to inflammation-related factors were observed in the lung tissues of mice exposed to 3R4F for two and four weeks. Chemokine (C-C motif) ligand 17, resistin-like alpha, and lipocalin 2 were among the upregulated genes. In our previous short-term tobacco inhalation study, these genes were identified as useful markers of emphysema effects induced by exposure to cigarette smoke from Peace cigarettes, detectable before pulmonary histological changes appeared. These effects were not observed in the PT+-exposed mice. These data suggest that PT+ caused less damage to the lungs of mice than 3R4F, particularly regarding the induction of emphysema.

DOI： 10.1293/tox.2024-0069
Evaluation of the Mechanisms Involved in the Development of Bladder Toxicity following Exposure to Occupational Bladder Cancer Causative Chemicals Using DNA Adductome Analysis Reviewed International coauthorship

Suzuki S, Gi M, Komiya M, Obikane A, Vachiraarunwong A, Fujioka M, Kakehashi A, Totsuka Y, Wanibuchi H

14 ( 1 ) 2023.12

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Publishing type：Research paper (scientific journal)

DOI： 10.3390/biom14010036

PubMed
DNA Methylation Aberrations in Dimethylarsinic Acid-Induced Bladder Carcinogenesis. Reviewed

Yamamoto T, Gi M, Yamashita S, Suzuki S, Fujioka M, Vachiraarunwong A, Guo R, Qiu G, Kakehashi A, Kato M, Uchida J, Wanibuchi H

Cancers 15 ( 21 ) 2023.11（ ISSN:2072-6694 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.3390/cancers15215274

PubMed
Recent Insights into the Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis. Reviewed

Kakehashi A, Suzuki S, Wanibuchi H

Cancers 15 ( 18 ) 2023.09（ ISSN:2072-6694 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.3390/cancers15184566

PubMed
Dimethylarsinic acid induces bladder carcinogenesis via the amphiregulin pathway. Reviewed

Shugo Suzuki, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi

Toxicology Letters 384 128 - 135 2023.08（ ISSN:0378-4274 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Dimethylarsinic acid (DMA) is a major metabolite in the urine of humans and rats exposed to inorganic arsenicals, and is reported to induce rat bladder carcinogenesis. In the present study, we focused on early pathways of carcinogenesis triggered by DMA that were also active in tumors. RNA expression in the bladder urothelium of rats treated with 0 and 200 ppm DMA in the drinking water for 4 weeks and in bladder tumors of rats treated with 200 ppm DMA for 2 years was initially examined using microarray analysis and Ingenuity Pathway Analysis (IPA). Expression of 160 genes was altered in both the urothelium of rats treated for 4 weeks with DMA and in DMA-induced tumors. IPA associated 36 of these genes with liver tumor diseases. IPA identified the amphiregulin (Areg)-regulated pathway as a Top Regulator Effects Network. Therefore, we focused on Areg and 6 of its target genes: cyclin A2, centromere protein F, marker of proliferation Ki-67, protein regulator of cytokinesis 1, ribonucleotide reductase M2, and topoisomerase II alpha. We confirmed high mRNA expression of Areg and its 6 target genes in both the urothelium of rats treated for 4 weeks with DMA and in DMA-induced tumors. RNA interference of human amphiregulin (AREG) expression in human urinary bladder cell lines T24 and UMUC3 decreased expression of AREG and its 6 target genes and decreased cell proliferation. These data suggest that Areg has an important role in DMA-induced rat bladder carcinogenesis.

DOI： 10.1016/j.toxlet.2023.08.004

PubMed
o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice. Reviewed

Yuka Yokota, Shugo Suzuki, Min Gi, Yukie Yanagiba, Nao Yoneda, Masaki Fujioka, Anna Kakehashi, Shigeki Koda, Hiroshi Suemizu, Hideki Wanibuchi

Toxicology 488 153483 - 153483 2023.04（ ISSN:0300-483X ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Occupational exposure to aromatic amines is one of the most important risk factors for urinary bladder cancer. When considering the carcinogenesis of aromatic amines, metabolism of aromatic amines in the liver is an important factor. In the present study, we administered ortho-toluidine (OTD) in the diet to mice for 4 weeks. We used NOG-TKm30 mice (control) and humanized-liver mice, established via human hepatocyte transplantation, to compare differences in OTD-induced expression of metabolic enzymes in human and mouse liver cells. We also investigated OTD-urinary metabolites and proliferative effects on the urinary bladder epithelium. RNA and immunohistochemical analyses revealed that expression of N-acetyltransferases mRNA in the liver tended to be lower than that of the P450 enzymes, and that OTD administration had little effect on N-acetyltransferase mRNA expression levels. However, expression of CYP3A4 was increased in the livers of humanized-liver mice, and expression of Cyp2c29 (human CYP2C9/19) was increased in the livers of NOG-TKm30 mice. OTD metabolites in the urine and cell proliferation activities in the bladder urothelium of NOG-TKm30 and humanized-liver mice were similar. However, the concentration of OTD in the urine of NOG-TKm30 mice was markedly higher than in the urine of humanized-liver mice. These data demonstrate differences in hepatic metabolic enzyme expression induced by OTD in human and mouse liver cells, and consequent differences in the metabolism of OTD by human and mouse liver cells. This type of difference could have a profound impact on the carcinogenicity of compounds that are metabolized by the liver, and consequently, would be important in the extrapolation of data from animals to humans.

DOI： 10.1016/j.tox.2023.153483

PubMed
Safety and Feasibility of Contrast-Enhanced Computed Tomography with a Nanoparticle Contrast Agent for Evaluation of Diethylnitrosamine-Induced Liver Tumors in a Rat Model. Reviewed

Nota T, Kageyama K, Yamamoto A, Kakehashi A, Yonezawa H, Jogo A, Sohgawa E, Murai K, Ogawa S, Miki Y

Academic Radiology 30 ( 1 ) 30 - 39 2023.01（ ISSN:1076-6332 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

DOI： 10.1016/j.acra.2022.03.027

PubMed
The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β-catenin signaling. Reviewed

Taisuke Matsue, Min Gi, Masayuki Shiota, Hirokazu Tachibana, Shugo Suzuki, Masaki Fujioka, Anna Kakehashi, Tomoki Yamamoto, Minoru Kato, Junji Uchida, Hideki Wanibuchi

Cancer Science 113 ( 8 ) 2642 - 2653 2022.08（ ISSN:1347-9032 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Carbonic anhydrases (CAs) play an important role in maintaining pH homeostasis. We previously demonstrated that overexpression of CA2 was associated with invasion and progression of urothelial carcinoma (UC) in humans. The purpose of the present study was to evaluate the effects of the CA inhibitor acetazolamide (Ace) on N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN)-induced bladder carcinogenesis in mice and explore the function of CA2 in muscle invasion by UC. Male mice were treated with 0.025% (experiment 1) or 0.05% BBN (experiment 2) in their drinking water for 10 weeks, then treated with cisplatin (Cis), Ace, or Cis plus Ace for 12 weeks. In experiment 1, the overall incidence of BBN-induced UCs was significantly decreased in the BBN→Ace and BBN→Cis+Ace groups. In experiment 2, the overall incidence of BBN-induced UCs was significantly decreased in the BBN→Cis+Ace group, and the incidence of muscle invasive UC was significantly decreased in both the BBN→Ace and the BBN→Cis+Ace groups. We also show that overexpression of CA2 by human UC cells T24 and UMUC3 significantly increased their migration and invasion capabilities, and that Ace significantly inhibited migration and invasion by CA2-overexpressing T24 and UMUC3 cells. These data demonstrate a functional association of CA2 with UC development and progression, confirming the association of CA2 with UC that we had shown previously by immunohistochemical analysis of human UC specimens and proteome analysis of BBN-induced UC in rats. Our finding that inhibition of CA2 inhibits UC development and muscle invasion also directly confirms that CA2 is a potential therapeutic target for bladder cancers.

DOI： 10.1111/cas.15467

PubMed
炭酸脱水酵素阻害剤のアセタゾラミドはβ-カテニンシグナル伝達の抑制を介して膀胱癌を抑制する(The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β-catenin signaling) Reviewed

Matsue Taisuke, Gi Min, Shiota Masayuki, Tachibana Hirokazu, Suzuki Shugo, Fujioka Masaki, Kakehashi Anna, Yamamoto Tomoki, Kato Minoru, Uchida Junji, Wanibuchi Hideki

Cancer Science 113 ( 8 ) 2642 - 2653 2022.08（ ISSN:1347-9032 ）

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Publishing type：Research paper (scientific journal)

N-ブチル-N-(4-ヒドロキシブチル)ニトロソアミン(BBN)で誘発した膀胱癌マウスモデルに対して、炭酸脱水酵素(CA)阻害剤アセタゾラミド(Ace)単独またはシスプラチン(Cis)との併用による抗腫瘍効果を検討した。C57BL/6J雄マウスを0.025%BBN(実験1)または0.05%BBN(実験2)を含む飲料水で10週間飼育した後、Cis、Ace、またはCis+Aceを12週間投与した。実験1では、BBN誘発膀胱癌の全発生率は、BBN→Ace群およびBBN→Cis+Ace群で有意に減少した。実験2では、BBN→Cis+Ace群においてBBN誘発膀胱癌の全発生率が有意に減少し、BBN→Ace群およびBBN→Cis+Ace群の両方で筋層浸潤性膀胱癌の発生率が有意に減少した。ヒト膀胱癌細胞T24とUMUC3におけるCA2の過剰発現は、その遊走・浸潤能を有意に増加させたが、AceはCA2過剰発現細胞の遊走・浸潤を有意に阻害した。以上より、CA2が膀胱癌の発生と進行に機能的に関与することが示された。
Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung Reviewed

Suzuki Shugo, Asai Kazuhisa, Gi Min, Kojima Kazuya, Kakehashi Anna, Oishi Yuji, Matsue Taisuke, Yukimatsu Nao, Hirata Kazuto, Kawaguchi Tomoya, Wanibuchi Hideki

Journal of Toxicologic Pathology 35 ( 3 ) 247 - 254 2022.07（ ISSN:0914-9198 ）（ eISSN:1881915X ）

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Publishing type：Research paper (scientific journal)

 Cigarette smoking is known to increase the risk of cancer and chronic obstructive pulmonary disease (COPD). In this study, we evaluated the effects of short-term nose-only inhalation exposure to cigarette smoke in mice. Male 10-week-old C57BL mice were exposed to clean air (control) or mainstream cigarette smoke for 1 h/day, 5 days/week, for 2 or 4 weeks. Exposure to cigarette smoke increased the number of inflammatory cells, especially neutrophils, in the bronchoalveolar lavage fluid, increased inflammatory cell infiltration foci, and caused an increase in the thickness of the peripheral bronchial epithelium. Microarray gene expression analysis indicated that smoke exposure induced inflammatory responses, including leukocyte migration and activation of phagocytes and myeloid cells, as early as two weeks after the initiation of exposure. Importantly, chemokine (C-C motif) ligand 17, resistin-like alpha, and lipocalin 2 were upregulated and may serve as useful markers of the toxic effects of exposure to cigarette smoke before pulmonary histological changes become evident.

DOI： 10.1293/tox.2021-0077

PubMed
マウス肺へのタバコ煙吸入曝露に応答するバイオマーカー(Response biomarkers of inhalation exposure to cigarette smoke in the mouse lung) Reviewed

Suzuki Shugo, Asai Kazuhisa, Gi Min, Kojima Kazuya, Kakehashi Anna, Oishi Yuji, Matsue Taisuke, Yukimatsu Nao, Hirata Kazuto, Kawaguchi Tomoya, Wanibuchi Hideki

Journal of Toxicologic Pathology 35 ( 3 ) 247 - 254 2022.07（ ISSN:0914-9198 ）

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Publishing type：Research paper (scientific journal)

タバコ煙による短期間の吸入曝露が、マウス肺に及ぼす影響について検討した。10週齢の雄性C57BL/6Jマウスに1日1時間、1週間に5日、2週間もしくは4週間にわたって、タバコ主流煙を鼻に吸入曝露させた。気管支肺胞洗浄液(BAL)を行い、BAL中の細胞を調べ、病理組織学的/免疫組織学的に解析した。その結果、BAL中の炎症細胞、特に好中球数の増加や炎症細胞の浸潤巣の増加が認められ、末梢気管支上皮細胞肥厚の増大も観察された。また、マイクロアレイ遺伝子発現解析では、タバコ煙吸入曝露を受けた日から2週間後には、白血球の遊走や食細胞ならびに骨髄性細胞の活性化を含む炎症反応が誘導されていた。タバコ煙の吸入により、ケモカイン(C-Cモチーフ)リガンド17(CCL17)、レジスチン様分子α(Rentla)およびリポカリン2(LCN2)が上方制御されていたことから、これらの分子により、明らかな肺組織の変化が生じる前に、タバコ煙曝露による毒性作用が予測されると考えられ、バイオマーカーとしての有用性が示唆された。
FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment. Reviewed

Tagami M, Kakehashi A, Katsuyama-Yoshikawa A, Misawa N, Sakai A, Wanibuchi H, Azumi A, Honda S

PloS one 17 ( 3 ) e0263895 2022

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DOI： 10.1371/journal.pone.0263895

PubMed
Expression of thrombospondin-1 in conjunctival squamous cell carcinoma is correlated to the Ki67 index and associated with progression-free survival. Reviewed

Tagami M, Kakehashi A, Sakai A, Misawa N, Katsuyama-Yoshikawa A, Wanibuchi H, Azumi A, Honda S

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 259 ( 10 ) 3127 - 3136 2021.10（ ISSN:0721-832X ）

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DOI： 10.1007/s00417-021-05236-7

PubMed
Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis. Reviewed

Anna Kakehashi, Shugo Suzuki, Masayuki Shiota, Nina Raymo, Min Gi, Taro Tachibana, Vasily Stefanov, Hideki Wanibuchi

Cancers 13 ( 14 ) 2021.07（ ISSN:2072-6694 ）

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In the present study, the role of a novel protein involved in neurite development and endoplasmic reticulum (ER) stress, canopy homolog 2 (CNPY2), was investigated in mouse and human hepatocarcinogenesis. Firstly, a sensitive quantitative and qualitative detection of protein expression using QSTAR Elite LC-Ms/Ms was performed for the analysis of lysates of microdissected hepatocellular altered foci (AF), adenomas (HCAs), carcinomas (HCCs) and peri-tumoral livers from C57Bl/6J mice treated with diethylnitrosamine (DEN) and then maintained for 27 or 38 weeks on basal diet. Significant overexpression of 18.5 kDa CNPY2 processed form was demonstrated in AF, HCAs and HCCs, while low expression was observed in the livers of DEN-treated and control mice. Furthermore, CNPY2 elevation in AF and tumors was coordinated with accumulation of numerous cytoskeletal proteins, including cytokeratins 8 and 18, actin, non-muscle myosin and septin 9 and those involved in ER and mitochondrial stresses such as calreticulin, prohibitins 1 and 2 and YME1-like-1. Knockdown of CNPY2 in Huh7 and HepG2 human liver cancer cells resulted in significant suppression of cell survival and invasive potential, inhibition of cyclin D1, induction of p21Waf1/Cip1 and suppression of the apoptosis inhibitor Bcl2. In contrast, transfection of a mouse CNPY2 (mCNPY2-Ds-Red) vector plasmid in Huh7 and HepG2 cancer cells, with subsequent accumulation of CNPY2 in the ER, resulted in significant increase in cancer cells survival. Clinicopathological analysis in 90 HCV-positive HCC patients, revealed significant association of CNPY2 overexpression with poor overall (p = 0.041) survival. Furthermore, CNPY2 increase was associated with vessel invasion (p = 0.038), poor histological differentiation (p = 0.035) and advanced clinical stage (p = 0.016). In conclusion, CNPY2 is a promising molecular target elevated early in hepatocarcinogenesis and prognostic marker for human HCV-associated HCC. CNPY2 is involved in the processes of ER stress, cell cycle progression, proliferation, survival and invasion of liver tumor cells.

DOI： 10.3390/cancers13143613

PubMed
Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis Reviewed International coauthorship

13 ( 6 ) 1216 2021.03

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Accumulation of 8-hydroxydeoxyguanosine, L-arginine and glucose metabolites by liver tumor cells are the important characteristic features of metabolic syndrome and non-alcoholic steatohepatitis-associated hepatocarcinogenesis Reviewed International coauthorship

Anna Kakehashi, Shugo Suzuki, Naomi Ishii, Takahiro Okuno, Yuko Kuwae, Masaki Fujioka, Min Gi, Vasily Stefanov, Hideki Wanibuchi

International Journal of Molecular Sciences 21 ( 20 ) 7746 2020.10

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To uncover mechanisms and explore novel biomarkers of obesity, type 2 diabetes (T2DM) and nonalcoholic steatohepatitis (NASH)-associated hepatocarcinogenesis, cellular and molecular alterations in the liver, and hepatocellular carcinomas (HCCs) were investigated in NASH model 60-week-old Tsumura, Suzuki, Obese Diabetic (TSOD) mice and NASH HCC patients. Markedly elevated lipid deposition, inflammation, fibrosis, and peroxisome proliferation in the liver, preneoplastic lesions, and HCCs of TSOD mice were accompanied by accumulation of polysaccharides in the cellular cytoplasm and nuclei and increase of oxidative DNA damage marker, 8-hydroxydeoxyguanosine (8-OHdG) formation in the liver and altered foci. Metabolomics of TSOD mice HCCs demonstrated significant elevation of the concentration of amino acid L-arginine, phosphocreatine, S-adenosylmethionine/S-adenosylhomocysteine ratio, adenylate, and guanylate energy charges in coordination with tremendous rise of glucose metabolites, mostly fructose 1,6-diphosphate. L-arginine accumulation in HCCs was associated with significant under-expression of arginase 1 (ARG1), suppression of the urea cycle, methionine and putrescine degradation pathways, activation of Ser and Thr kinase Akt AKT, phosphoinositide 3-kinase (PI3K), extracellular signal-regulated kinase 1/2 (ERK1/2) kinases, β-catenin, mammalian target of rapamycin (mTOR), and cell proliferation. Furthermore, clinicopathological analysis in 20 metabolic syndrome/NASH and 80 HCV-positive HCC patients demonstrated significant correlation of negative ARG1 expression with poor tumor differentiation, higher pathological stage, and significant decrease of survival in metabolic syndrome/NASH-associated HCC patients, thus indicating that ARG1 could become a potential marker for NASH HCC. From these results, formation of oxidative stress and 8-OHdG in the DNA and elevation of glucose metabolites and L-arginine due to ARG1 suppression in mice liver cells are the important characteristics of T2DM/NASH-associated hepatocarcinogenesis, which may take part in activating oxidative stress resistance, synthesis of phosphocreatine, cell signaling, methylation, and proliferation.
F344ラットにおける膀胱発癌物質の検出のためのバイオマーカーとしてのγ-H2AXの役割(Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats) Reviewed

Suzuki Shugo, Gi Min, Toyoda Takeshi, Kato Hiroyuki, Naiki-Ito Aya, Kakehashi Anna, Ogawa Kumiko, Takahashi Satoru, Wanibuchi Hideki

Journal of Toxicologic Pathology 33 ( 4 ) 279 - 285 2020.10（ ISSN:0914-9198 ）

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ラットにおける非遺伝性膀胱発癌物質の検出に、ヒストンH2AXのセリン139のリン酸化(γ-H2AX)が利用できるか検討した。6週齢雄F344ラットに15種の化学物質を4週間投与した。免疫組織化学分析より、3種の遺伝毒性膀胱発癌物質の全てと7種の非遺伝毒性膀胱発癌物質のうち6種が、ラットの膀胱尿路上皮におけるγ-H2AX形成を有意に増大させた。5種の膀胱非発癌物質のうち4種は、遺伝毒性に関係なく膀胱上皮におけるγ-H2AX形成を上昇させなかった。以上より、γ-H2AXはラットにおける遺伝毒性と非遺伝毒性の膀胱発癌物質を検出するための、有用なバイオマーカーになりうると考えられた。
Expression, intracellular localization, and mutation of EGFR in conjunctival squamous cell carcinoma and the association with prognosis and treatment Reviewed

Atsushi Sakai, Mizuki Tagami, Anna Kakehashi, Atsuko Katsuyama-Yoshikawa, Norihiko Misawa, Hideki Wanibuchi, Atsushi Azumi, Shigeru Honda

PLoS One 15 ( 8 ) e0238120 2020.08

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Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats. Reviewed

Shugo Suzuki, Min Gi, Takeshi Toyoda, Hiroyuki Kato, Aya Naiki-Ito, Anna Kakehashi, Kumiko Ogawa, Satoru Takahashi, Hideki Wanibuchi

Journal of Toxicologic Pathology 33 ( 4 ) 279 - 285 2020.08

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Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal
Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model Reviewed

Fujioka Masaki, Suzuki Shugo, Gi Min, Kakehashi Anna, Oishi Yuji, Okuno Takahiro, Yukimatsu Nao, Wanibuchi Hideki

ARCHIVES OF TOXICOLOGY 2020.02（ ISSN:0340-5761 ）

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以前の研究では妊娠中のCD-1マウスは、妊娠8〜18日目から飲料水に200ppmのジメチルアルシン酸（DMA）を投与され、84週齢の子孫で腫瘍形成が評価された。 DMAは、雄のコントロールの子孫と比較して、肺腺癌（10.0％）および総腫瘍（33.3％）の発生率を上昇させた。また、雄の子孫における肝細胞癌の発生率（10.0％）も上昇した。 DMAとその代謝物は、DMA処理新生児マウスの肺で検出された。マイクロアレイおよびリアルタイムPCR分析により、新生児および6週齢のDMA処理マウスの肺でkeratin 8（Krt8）の高発現が検出された。また、ウエスタンブロット分析は、DMAが雄マウスの肺ではヒストンH3K9のメチル化を上昇した。H3K9me3抗体を使用したクロマチン免疫沈降シーケンス（ChIP-seq）分析により、DMAとコントロール群マウスの間ではヘテロクロマチン形成に違いが見られた。Krt8の高発現は、雄の子孫の肺の腺腫および腺癌でも検出された。これらのデータは、経胎盤DMA治療が雄マウスの肺および肝臓の発癌を促進した。肺では、DMAはヒストンH3K9の異常なメチル化を引き起こし、Krt8発現を増加させ、細胞増殖を促進した。

DOI： 10.1007/s00204-020-02665-x

PubMed
Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats Reviewed

Yukimatsu Nao, Gi Min, Okuno Takahiro, Fujioka Masaki, Suzuki Shugo, Kakehashi Anna, Yanagiba Yukie, Suda Megumi, Koda Shigeki, Nakatani Tatsuya, Wanibuchi Hideki

ARCHIVES OF TOXICOLOGY 93 ( 12 ) 3617 - 3631 2019.12（ ISSN:0340-5761 ）

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最近の疫学研究は、アミンアセトアセト-o-トルイジド（AAOT）の職業的曝露により日本では膀胱癌の著しい増加が見られた。しかし、AAOTの発がん性についてはほとんど知られていない。 AAOTの膀胱発がん性を評価するために、雄と雌のF344ラットをN-ブチル-N-（4-ヒドロキシブチル）ニトロソアミン（BBN）で4週間処理した後、31週間を0、0.167、0.5、または1.5％AAOTの混じ投与を行った。その結果、雄と雌ラットの0.5および1.5％AAOT群では膀胱腫瘍の発生率と個数は、有意に増加した。尿中にAAOTの最も多い代謝産物（ヒト膀胱発がん物質）o-トルイジン（OTD）のレベルが上昇していた。遺伝子発現解析により、JUNとその下流の標的遺伝子の発現は、1.5％AAOTを投与した雄ラットの尿路上皮で増加したことが明らかになった。これらの結果は、AAOTがラットのBBN誘発膀胱発がんを促進し、JUNとその下流の標的遺伝子の過剰発現がAAOTの膀胱発がん性に関与している可能性を示唆された。

DOI： 10.1007/s00204-019-02605-4

PubMed
Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats Reviewed

Gi Min, Fujioka Masaki, Totsuka Yukari, Matsumoto Michiharu, Masumura Kenichi, Kakehashi Anna, Yamaguchi Takashi, Fukushima Shoji, Wanibuchi Hideki

MUTAGENESIS 34 ( 3 ) 279 - 287 2019.05（ ISSN:0267-8357 ）

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本研究では、低用量の食餌性遺伝毒性発がん物質2-アミノ-3-メチルイミダゾ[4,5-f]キノリン（IQ）の変異原性と発がん性を検討した。雄のF344 gpt deltaトランスジェニックラットに、0、0.1、1、10、または100 ppmの4週間をIQを混じ投与した。10および100 ppm群では肝臓のgpt導入遺伝子変異の頻度は、有意に増加した。さらに、1、10、100 ppm群で変異スペクトルが変更した。1、10、100 ppmのIQを用量した肝臓では依存的に、G：CからT：Aの変異が増加した。また、 100 ppm G：CからA：T、A：TからT：AおよびA：TからC：Gへの移行の頻度は上昇した。100 ppm群ではラットの肝臓の前がん病変であるGST-P陽性病巣の増加も観察された。

DOI： 10.1093/mutage/gez015

PubMed
Acetoaceto-o-toluidide enhances cellular proliferative activity in the urinary bladder of rats. Reviewed

Takahiro Okuno, Min Gi, Masaki Fujioka, Nao Yukimatu, Anna Kakehashi, Akito Takeuchi , Gingi Endo , Yoko Endo, Hideki Wanibuchi

TOXICOLOGICAL SCIENCES 169 ( 2 ) 456 - 464 2019.02（ ISSN:1096-6080 ）

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Acetoaceto-o-toluidide (AAOT) is made from ortho-toluidine (OTD) and is used for the synthesis of pigments. A report of occupational urinary bladder carcinomas in Japanese workers chronically exposed to OTD and AAOT has recently been published. OTD is a well-known human urinary bladder carcinogen; however, little is known about the toxicity and the carcinogenicity of AAOT. The aim of the present study is to evaluate the toxic effects of AAOT on urinary bladder epithelium. In vitro, the cytotoxicities of AAOT and OTD were evaluated in rat (MYP3) and human (1T1) urothelial cells. The LC50 of AAOT was higher than that of OTD in both MYP cells and 1T1 cells. In vivo, 6-week-old male and female F344 rats were fed diets supplemented with 0%, 1.5%, or 3% AAOT for 4 weeks. Incidences of simple hyperplasia, cell proliferative activity, and γ-H2AX expression, which is a novel marker for the prediction of carcinogenicity, were significantly increased in a dose-dependent manner in the bladder urothelium of male and female rats administered AAOT. Furthermore, in male and female rats administered AAOT, the major urine metabolite of AAOT was OTD. These results demonstrate that AAOT has proliferation-enhancing activity and suggest that OTD metabolized from AAOT may play a pivotal role in the deleterious effects of AAOT in rats. The results of the present study also indicate that AAOT, like other carcinogenic aromatic amines, is likely to be a human bladder carcinogen.

DOI： 10.1093/toxsci/kfz051

PubMed
A chronic toxicity study of diphenylarsinic acid in the drinking water of C57BL/6J mice for 52 weeks. Reviewed

Takashi Yamaguchi, Min Gi, Masaki Fujioka, Yoshiyuki Tago, Anna Kakehashi, Hideki Wanibuchi

JOURNAL OF TOXICOLOGIC PATHOLOGY 32 ( 3 ) 127 - 134 2019（ ISSN:0914-9198 ）

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Diphenylarsinic acid (DPAA), a neurotoxic organic arsenical, is present in the groundwater and soil in some regions of Japan due to illegal dumping. The purpose of the present study was to evaluate the potential toxicity of DPAA when administered to mice in their drinking water for 52 weeks. DPAA was administered to mice at concentrations of 0, 6.25, 12.5, and 25 ppm in their drinking water for 52 weeks. There were no significant differences in final body weights between the control groups and the DPAA treatment groups in male or female mice. Relative liver weights were significantly increased in males treated with 25 ppm DPAA, and absolute liver weights were significantly decreased in female mice treated with 25 ppm DPAA. In female mice, cholangitis and simple bile duct hyperplasia were observed in the 12.5 and 25 ppm DPAA groups, and focal necrosis of hepatocytes was observed in the 25 ppm DPAA group. Proteomic analysis and Ingenuity Pathway Analysis identified 18 proteins related to hepatotoxicity that were overexpressed in the female 25 ppm group. The phase I metabolic enzyme CYP2E1 was one of these overexpressed proteins. Immunostaining confirmed high expression of CYP2E1 in the livers of females in the 25 ppm group. These results suggest that DPAA is toxic to the intrahepatic bile duct epithelium and hepatocytes in female mice and that CYP2E1 might be involved in DPAA-associated toxicity. The no-observed-adverse-effect levels of DPAA were 12.5 ppm for males and 6.25 ppm for females under the conditions of this study.

DOI： 10.1293/tox.2018-0067

CiNii Article
Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats. Reviewed

Min Gi, Masaki Fujioka, Shotaro Yamano, Anna Kakehashi, Yuji Oishi, Takahiro Okuno, Nao Yukimatsu, Takashi Yamaguchi, Yoshiyuki Tago, Mitsuaki Kitano, Shim-mo, Hideki Wanibuchi

ARCHIVES OF TOXICOLOGY 92 ( 12 ) 3565 - 3583 2018.12（ ISSN:0340-5761 ）

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DOI： 10.1007/s00204-018-2316-7

PubMed
Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer. Reviewed

Yasuomi Shimizu, Satoshi Tamada, Minoru Kato, Yuji Takeyama, Masaki Fujioka, Anna Kakehashi, Tatsuya Nakatani, Hideki Wanibuchi, Min Gi

EXPERIMENTAL AND THERAPEUTIC MEDICINE 16 ( 6 ) 4463 - 4470 2018.12（ ISSN:1792-0981 ）

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DOI： 10.3892/etm.2018.6787

PubMed
mTOR activation in liver tumors is associated with metabolic syndrome and non-alcoholic steatohepatitis in both mouse models and humans. Reviewed

Takahiro Okuno, Anna Kakehashi, Naomi Ishii, Masaki Fujioka, Min Gi, Hideki Wanibuchi

CANCERS 10 ( 12 ) 2018.12（ ISSN:2072-6694 ）

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DOI： 10.3390/cancers10120465

PubMed
Quantitative Approaches to Assess Key Carcinogenic Events of Genotoxic Carcinogens. Reviewed

Shoji Fukushima, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi, Michiharu Matsumoto

TOXICOLOGICAL RESEARCH 34 ( 4 ) 291 - 296 2018.10（ ISSN:1976-8257 ）

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DOI： 10.5487/TR.2018.34.4.291

PubMed
In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats. Reviewed

Min Gi, Masaki Fujioka, Anna Kakehashi, Takahiro Okuno, Kenichi Masumura, Takehiko Nohmi, Michiharu Matsumoto, Masako Omori, Hideki Wanibuchi, Shoji Fukushima

ARCHIVES OF TOXICOLOGY 92 ( 10 ) 3207 - 3221 2018.10（ ISSN:0340-5761 ）

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DOI： 10.1007/s00204-018-2282-0

PubMed
Carcinogenicity induced by prenatal exposure to dimethylarsinic acid in CD1 mice Reviewed

Masaki Fujioka, Min Gi, Kenji Kumada, Takahiro Okuno, Anna Kakehashi, Hideki Wanibuchi

CANCER SCIENCE 109 584 - 584 2018.01（ ISSN:1349-7006 ）

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Roles of Ink4a/Arf in BBN-induced mouse bladder carcinogenesis Reviewed

Kohyama Yuki, Gi Min, Fujioka Masaki, Kumada Kenji, Okuno Takahiro, Kakehashi Anna, Wanibuchi Hideki

CANCER SCIENCE 109 167 - 167 2018.01（ ISSN:1349-7006 ）

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Proteome characteristics of non-alcoholic steatohepatitis liver tissue and associated hepatocellular carcinomas. Reviewed

109 584 - 584 2018.01（ ISSN:1349-7006 ）

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Inhibitory effects of acetazolamide on the BBN-induced mouse bladder carcinogenesis Reviewed

Min Gi , Masaki Fujioka, Anna Kakehashi, Takahiro Okuno, Yuki Kouyama, Kenji Kumada, Hideki Wanibuchi

CANCER SCIENCE 109 305 - 305 2018.01（ ISSN:1349-7006 ）

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Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis Reviewed

Kakehashi Anna, Ishii Naomi, Okuno Takahiro, Fujioka Masaki, Gi Min, Wanibuchi Hideki

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 ( 8 ) 2017.08（ ISSN:1422-0067 ）

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DOI： 10.3390/ijms18081801

PubMed
F344ラットへのジフェニルアルシン酸含有飲料水104週間投与の発癌性に関する検討(A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks) Reviewed

Yamaguchi Takashi, Gi Min, Fujioka Masaki, Doi Kenichiro, Okuno Takahiro, Kakehashi Anna, Wanibuchi Hideki

(一社)日本毒性学会　The Journal of Toxicological Sciences 42 ( 4 ) 475 - 483 2017.08（ ISSN:0388-1350 ）

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ジフェニルアルシン酸(DPAA)含有飲料水を雌雄F344ラットに104週間摂取させ、過去に52週間DPAAを投与した際に認められた肝内胆管肥厚が腫瘍に進展するか否かを含め、DPAAによる発癌性を検討した。雌雄ラットを4群に分け、飲料水中のDPAA濃度を0、5、10、20ppmの4段階に設定し、雌雄の群間で発癌性を比較した。その結果、雌性20ppm群では有意な生存率の低下を認め、雄性20ppm群と雌性10、20ppm群では有意な体重の減少を認めた。全組織における腫瘍の包括的組織病理学的検査では、雌雄ラットの全群で、どの器官にも腫瘍発生率の有意な上昇を認めなかった。以上より、DPAAは雌雄F344ラットの発癌物質ではないと考えられた。
Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers Reviewed

Tachibana Hirokazu, Gi Min, Kato Minoru, Yamano Shotaro, Fujioka Masaki, Kakehashi Anna, Hirayama Yukiyoshi, Koyama Yuki, Tamada Satoshi, Nakatani Tatsuya, Wanibuchi Hideki

CANCER SCIENCE 108 ( 3 ) 331 - 337 2017.03（ ISSN:1349-7006 ）

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DOI： 10.1111/cas.13143

PubMed
Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas Reviewed

Kakehashi Anna, Stefanov Vasily E., Ishii Naomi, Okuno Takahiro, Fujii Hideki, Kawai Kazuaki, Kawada Norifumi, Wanibuchi Hideki

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 18 ( 2 ) 2017.02（ ISSN:1422-0067 ）

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DOI： 10.3390/ijms18020434

PubMed
A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks Reviewed

Yamaguchi Takashi, Gi Min, Yamano Shotarou, Fujioka Masaki, Tatsumi Kumiko, Kawachi Satoko, Ishii Naomi, Doi Kenichiro, Kakehashi Anna, Wanibuchi Hideki

EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 69 ( 1 ) 1 - 7 2017.01（ ISSN:0940-2993 ）

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DOI： 10.1016/jetp.2016.10.002
Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital Reviewed

Kakehashi Anna, Ishii Naomi, Okuno Takahiro, Fujioka Masaki, Gi Min, Fukushima Shoji, Wanibuchi Hideki

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017 8541064 2017（ ISSN:1942-0900 ）

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DOI： 10.1155/2017/8541064

PubMed
Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis Reviewed

Doi Kenichiro, Fujioka Masaki, Sokuza Yui, Ohnishi Mariko, Gi Min, Takeshita Masanori, Kumada Kenji, Kakehashi Anna, Wanibuchi Hideki

IN VIVO 31 ( 2 ) 187 - 197 2017（ ISSN:0258-851X ）

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DOI： 10.21873/invivo.11044

PubMed
A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks. Reviewed

Yamaguchi T, Gi M, Fujioka M, Doi K, Okuno T, Kakehashi A, Wanibuchi H

The Journal of Toxicological Sciences 42 ( 4 ) 475 - 483 2017（ ISSN:0388-1350 ）

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Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

Diphenylarsinic acid (DPAA), a neurotoxic organic arsenical used as a chemical warfare agent, is present in the groundwater and soil in some regions of Japan due to illegal dumping after World War II. We previously demonstrated that DPAA promotes diethylnitrosamine-induced liver carcinogenesis in a medium-term rat liver bioassay. The purpose of the present study was to evaluate the potential carcinogenicity of DPAA, including investigation of whether the bile duct hyperplasia in the liver that was observed in a previous 52 week rat chronic study develops into a tumor, when administered to rats in their drinking water for 104 weeks. DPAA was administered to groups 1-4 at concentrations of 0, 5, 10, and 20 ppm in their drinking water for 104 weeks. A significant decrease in survival rate was found for females in the 20 ppm DPAA group. Body weights of males in the 20 ppm and females in the 10 and 20 ppm DPAA groups were significantly decreased compared to the controls. Overall histopathological evaluation of neoplasms in all tissues showed no significant increase of tumor incidence in any organ or tissue of the 5, 10, or 20 ppm DPAA-treated male or female F344 rats. In conclusion, the present study demonstrated that DPAA is not a complete carcinogen in male or female F344 rats.

DOI： 10.2131/jts.42.475

PubMed

CiNii Article
Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay Reviewed

Ishii Naomi, Gi Min, Fujioka Masaki, Yamano Shotaro, Okumura Mai, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会　JOURNAL OF TOXICOLOGIC PATHOLOGY 30 ( 1 ) 39 - 45 2017（ ISSN:0914-9198 ）

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 We have previously demonstrated that diphenylarsinic acid (DPAA) promotes liver carcinogenesis in rats in a medium-term liver carcinogenicity bioassay. However, the effects of DPAA on other organs have not been determined. In the present study, the effects of DPAA on carcinogenesis were investigated using a rat multiorgan carcinogenicity bioassay. A total of 60 six-week-old male F344 rats were treated with the carcinogens diethylnitrosamine, N-butyl-N-(4-hydroxybutyl) nitrosamine, N-methyl-N-nitrosourea, N-bis (2-hydroxypropyl) nitrosamine, and 1,2-dimethylhydrazine dihydrochloride to initiate carcinogenesis in multiple organs. After initiation, DPAA was given at a dose of 0, 5, or 20 ppm in drinking water for 27 weeks. The incidences of moderate and severe bile duct hyperplasia were significantly increased in the 20 ppm DPAA group (29.4%, 70.6%, respectively) compared with the 0 ppm DPAA group (0%, 0%, respectively), and the incidence and multiplicity of cholangioma were significantly increased in the 20 ppm DPAA group (29.4%, 0.4 ± 0.8/rat) compared with the 0 ppm DPAA group (0%, 0/rat). The total number and average area of glutathione S-transferase placenta form-positive foci, preneoplastic lesions in rat livers, were significantly increased in the 20 ppm DPAA group (10.5 ± 2.2/cm2, 5.3 ± 1.7 mm2/cm2) compared with the 0 ppm DPAA group (6.2 ± 2.9/cm2, 2.4 ± 1.4 mm2/cm2). In conclusion, our results demonstrate that DPAA promotes hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay; no promotion effects were observed in other organs.

DOI： 10.1293/tox.2016-0049

PubMed

CiNii Article
Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats Reviewed

Fujioka Masaki, Gi Min, Kawachi Satoko, Tatsumi Kumiko, Ishii Naomi, Doi Kenichiro, Kakehashi Anna, Wanibuchi Hideki

JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA 49 125 - 130 2016.11（ ISSN:1001-0742 ）

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DOI： 10.1016/j.jes.2016.07.005

PubMed
Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats Reviewed

Kakehashi Anna, Yoshida Midori, Tago Yoshiyuki, Ishii Naomi, Okuno Takahiro, Gi Min, Wanibuchi Hideki

TOXINS 8 ( 11 ) 2016.11（ ISSN:2072-6651 ）

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DOI： 10.3390/toxins8110275

PubMed
Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats Reviewed

Kakehashi Anna, Ishii Naomi, Fujioka Masaki, Doi Kenichiro, Gi Min, Wanibuchi Hideki

PLOS ONE 11 ( 7 ) e0158654 2016.07（ ISSN:1932-6203 ）

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DOI： 10.1371/journal.pone.0158654

PubMed
Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose-Response for Key Events in Rat Hepatocarcinogenesis Reviewed

Shoji Fukushima, Min Gi, Anna Kakehashi, Hideki Wanibuchi

Thresholds of Genotoxic Carcinogens: From Mechanisms to Regulation 1 - 17 2016.05

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This chapter provides quantitative data on key events in rat hepatocarcinogenesis of three genotoxic carcinogens: 2-amino-3,8-dimethylimidazo[4,5-. f]quinoxaline (MeIQx), 2-amino-3-methylimidazo[4,5-. f]quinoline (IQ), and N-nitrosodiethylamine (DEN). MeIQx at very low doses increased formation of DNA-MeIQx adducts
somewhat higher doses caused elevation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) DNA damage
at still higher doses gene mutations occurred
the much higher doses induced formation of glutathione S-transferase placental form (GST-P)-positive foci which are preneoplastic lesions. These data indicate that key events of MeIQx carcinogenesis showed the expected trend of doses for quantitative assessment. Similarly, only the highest dose of IQ caused an increase in the number of GST-P-positive foci in the liver, while IQ-DNA adduct formation was observed with very low doses. Moreover, treatment with DEN at low doses had no observed effect on the development of GST-P-positive foci in the liver. These data contribute to understand that genotoxic carcinogens have a threshold, at least a practical threshold for their carcinogenicity.

DOI： 10.1016/B978-0-12-801663-3.00001-7
CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus-positive patients with resected hepatocellular carcinoma Reviewed

Kakehashi Anna, Ishii Naomi, Sugihara Eiji, Gi Min, Saya Hideyuki, Wanibuchi Hideki

CANCER SCIENCE 107 ( 5 ) 609 - 618 2016.05（ ISSN:1349-7006 ）

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DOI： 10.1111/cas.12908

PubMed
Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens Reviewed

Fukushima Shoji, Gi Min, Kakehashi Anna, Wanibuchi Hideki, Matsumoto Michiharu

MUTAGENESIS 31 ( 3 ) 341 - 346 2016.05（ ISSN:0267-8357 ）

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DOI： 10.1093/mutage/gev049

PubMed
Preventive Effects of Spirogyra neglecta and a Polysaccharide Extract against Dextran Sodium Sulfate Induced Colitis in Mice. Reviewed

Taya S, Kakehashi A, Wongpoomchai R, Gi M, Ishii N, Wanibuchi H

Asian Pacific journal of cancer prevention : APJCP 17 ( 4 ) 2235 - 45 2016（ ISSN:1513-7368 ）

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PubMed
Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters Reviewed

Gi Min, Fujioka Masaki, Yamano Shotaro, Shimomura En I., Kanki Masayuki, Kawachi Satoko, Tachibana Hirokazu, Tatsumi Kumiko, Fang He, Ishii Naomi, Kakehashi Anna, Wanibuchi Hideki

JOURNAL OF TOXICOLOGICAL SCIENCES 40 ( 5 ) 647 - 656 2015.10（ ISSN:0388-1350 ）

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Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats Reviewed

Xie Xiao-Li, Gi Min, Fujioka Masaki, Doi Kenichiro, Yamano Shotaro, Tachibana Hirokazu, Fang He, Kakehashi Anna, Wanibuchi Hideki

FOOD AND CHEMICAL TOXICOLOGY 83 193 - 200 2015.09（ ISSN:0278-6915 ）

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DOI： 10.1016/j.fct.2015.06.007

PubMed
Integrative analyses of miRNA and proteomics identify potential biological pathways associated with onset of pulmonary fibrosis in the bleomycin rat model Reviewed

Fukunaga Satoki, Kakehashi Anna, Sumida Kayo, Kushida Masahiko, Asano Hiroyuki, Gi Min, Wanibuchi Hideki

TOXICOLOGY AND APPLIED PHARMACOLOGY 286 ( 3 ) 188 - 197 2015.08（ ISSN:0041-008X ）

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DOI： 10.1016/j.taap.2015.04.014

PubMed
Novel biomarkers for gastric cancer stem cells utilizing comparative proteomics analysis Reviewed

Yashiro Masakazu, Morisaki Tamami, Hasegawa Tsuyoshi, Kakehashi Anna, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

CANCER RESEARCH 75 2015.08（ ISSN:0008-5472 ）

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DOI： 10.1158/1538-7445.AM2015-1405
Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice Reviewed

Gi Min, Fujioka Masaki, Yamano Shotaro, Shimomura Eri, Ishii Naomi, Kakehashi Anna, Takeshita Masanori, Wanibuchi Hideki

TOXICOLOGICAL SCIENCES 145 ( 1 ) 196 - 208 2015.05（ ISSN:1096-6080 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1093/toxsci/kfv045

PubMed
エチル-ターシャリー-ブチルエーテルを短期投与したラット肝臓における細胞増殖の誘導(Induction of cell proliferation in the rat liver by the short-term administration of ethyl tertiary-butyl ether) Reviewed

Kakehashi Anna, Hagiwara Akihiro, Imai Norio, Wei Min, Fukushima Shoji, Wanibuchi Hideki

日本毒性病理学会　Journal of Toxicologic Pathology 28 ( 1 ) 27 - 32 2015.01（ ISSN:0914-9198 ）

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F344ラットへの短期間での高用量エチル-tertiary-ブチルエーテル(ETBE)投与が肝細胞増殖に与える影響について検討した。F344ラットに1000mg/kg(発癌促進効果を示す量の2倍量)のETBEを1日2回、3、10、17および28日間投与した。ETBE投与群では対照群に比べ、肝重量と腎重量が有意に増加した。顕微鏡的変化は肝臓でのみ認められ、ETBE投与群では全ての時点で肝肥大が見られた(day3で33%、day10で60%、day17およびday28で100%)。ETBE投与期間が3日から28日に増えるに従い、肝肥大の程度も亢進した。ETBE投与群ではday17においてアポトーシス細胞数が増加し、またday3およびday28におけるETBE投与群の肝細胞の有糸分裂は対照群に比べ増大していた。ETBEの短期投与は細胞増殖活性を増大させ、再生的細胞増殖を誘導することにより、以上、肝癌発癌作用に寄与すると考えられた。
Paraneoplastic Ma Antigen-Like 1 as a Potential Prognostic Biomarker in Human Pancreatic Ductal Adenocarcinoma Reviewed

Kuwae Yuko, Kakehashi Anna, Wakasa Kenichi, Wei Min, Yamano Shotaro, Ishii Naomi, Ohsawa Masahiko, Wanibuchi Hideki

PANCREAS 44 ( 1 ) 106 - 115 2015.01（ ISSN:0885-3177 ）

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DOI： 10.1097/MPA.0000000000000220

PubMed
Induction of cell proliferation in the rat liver by the short-term administration of ethyl tertiary-butyl ether. Reviewed

Kakehashi A, Hagiwara A, Imai N, Wei M, Fukushima S, Wanibuchi H

日本毒性病理学会　Journal of toxicologic pathology 28 ( 1 ) 27 - 32 2015.01（ ISSN:0914-9198 ）

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In the present study, in continuation of our previous experiment in order to investigate the mode of action (MOA) of ethyl tertiary-butyl ether (ETBE) hepatotumorigenicity in rats, we aimed to examine alterations in cell proliferation, that are induced by short-term administration of ETBE. F344 rats were administered ETBE at doses of 0, and 1,000 mg/kg body weight twice a day by gavage for 3, 10, 17 and 28 days. It was found that the previously observed significant increase of P450 total content and hydroxyl radical levels after 7 days of ETBE administration, and 8-OHdG formation at day 14, accompanied by accumulation of CYP2B1/2B2, CYP3A1/3A2, CYP2C6, CYP2E1 and CYP1A1 and downregulation of DNA oxoguanine glycosylase 1, was preceded by induction of cell proliferation at day 3. Furthermore, we observed an increase in regenerative cell proliferation as a result of ETBE treatment at day 28, followed by induction of cell cycle arrest and apoptosis by day 14. These results indicated that short-term administration of ETBE led to a significant early increase in cell proliferation activity associated with induction of oxidative stress, and to a regenerative cell proliferation as an adaptive response, which could contribute to the hepatotumorigenicity of ETBE in rats.

DOI： 10.1293/tox.2014-0056

PubMed

CiNii Article
Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters. Reviewed

Gi M, Fujioka M, Yamano S, Shimomura E, Kanki M, Kawachi S, Tachibana H, Tatsumi K, Fang H, Ishii N, Kakehashi A, Wanibuchi H

一般社団法人　日本毒性学会　The Journal of toxicological sciences 40 ( 5 ) 647 - 56 2015（ ISSN:0388-1350 ）

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Based on the findings of epidemiological studies in Japan that occupational exposure to 1,2-dichloropropane (1,2-DCP) was associated with increased cholangiocarcinomas, 1,2-DCP has recently been classified as being carcinogenic to humans (Group 1). However, the cholangiocarcinogenicity of 1,2-DCP has not been demonstrated experimentally, and it was negative for cholangiocarcinogenicity in rats and mice. The present study determined the effects of 1,2-DCP on N-nitrosobis(2-oxopropyl)amine (BOP)-induced cholangiocarcinogenesis in male hamsters. We found that 1,2-DCP did not enhance the development of BOP-induced atypical biliary hyperplasia and did not induce any lesions in liver bile duct when administered alone. Notably, 1,2-DCP had no effect on the proliferative activity of bile duct epithelial cells regardless of BOP-initiation. These results demonstrate that 1,2-DCP lacks promoting effects on BOP-induced cholangiocarcinogenesis and suggest the possibility that 1,2-DCP is not cholangiocarcinogenic to the hamster in the present model. In addition, 1,2-DCP also lacks promoting effects on pancreatic, lung, and renal carcinogenesis. As the occurrence of occupational cholangiocarcinomas in Japan might be attributed to exposure to multiple chemicals, the results of the present study indicate that it will be necessary to determine the cholangiocarcinogenic effects of concurrent exposure of 1,2-DCP and the other halogen solvents to which workers with cholangiocarcinomas were exposed.

DOI： 10.2131/jts.40.647

PubMed

CiNii Article
Valerian Inhibits Rat Hepatocarcinogenesis by Activating GABA(A) Receptor-Mediated Signaling Reviewed

Kakehashi Anna, Kato Ayumi, Ishii Naomi, Wei Min, Morimura Keiichirou, Fukushima Shoji, Wanibuchi Hideki

PLOS ONE 9 ( 11 ) e113610 2014.11（ ISSN:1932-6203 ）

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DOI： 10.1371/journal.pone.0113610

PubMed
Comparative Proteomics Analysis of Gastric Cancer Stem Cells Reviewed

Morisaki Tamami, Yashiro Masakazu, Kakehashi Anna, Inagaki Azusa, Kinoshita Haruhito, Fukuoka Tatsunari, Kasashima Hiroaki, Masuda Go, Sakurai Katsunobu, Kubo Naoshi, Muguruma Kazuya, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

PLOS ONE 9 ( 11 ) e110736 2014.11（ ISSN:1932-6203 ）

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DOI： 10.1371/journal.pone.0110736

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Threshold of Genotoxic Carcinogens: Consideration from No-Effect Doses for Cancer-Related Markers in Chemical Carcinogenesis Reviewed

Fukushima Shoji, Gi Min, Kakehashi Anna, Wanibuchi Hideki

MUTAGENESIS 29 ( 6 ) 554 - 554 2014.11（ ISSN:0267-8357 ）

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A Comparative Study of Clinicopathological Features Between Simple Bone Cysts of the Calcaneus and the Long Bone Reviewed

Takada Jun, Hoshi Manabu, Oebisu Naoto, Ieguchi Makoto, Kakehashi Anna, Wanibuchi Hideki, Nakamura Hiroaki

FOOT & ANKLE INTERNATIONAL 35 ( 4 ) 374 - 382 2014.04（ ISSN:1071-1007 ）

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DOI： 10.1177/1071100713519600

PubMed
Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways Reviewed

Kakehashi Anna, Hagiwara Akihiro, Imai Norio, Nagano Kasuke, Nishimaki Fukumi, Banton Marcy, Wei Min, Fukushima Shoji, Wanibuchi Hideki

TOXICOLOGY AND APPLIED PHARMACOLOGY 273 ( 2 ) 390 - 400 2013.12（ ISSN:0041-008X ）

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DOI： 10.1016/j.taap.2013.09.016

PubMed
Novel medium-term carcinogenesis model for lung squamous cell carcinoma induced by N-nitrosotris-chloroethylurea in mice Reviewed

Tago Yoshiyuki, Yamano Shotaro, Wei Min, Kakehashi Anna, Kitano Mitsuaki, Fujioka Masaki, Ishii Naomi, Wanibuchi Hideki

CANCER SCIENCE 104 ( 12 ) 1560 - 1566 2013.12（ ISSN:1349-7006 ）

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DOI： 10.1111/cas.12289

PubMed
マウス膀胱発癌に及ぼすタバコ主流煙吸入による修飾作用の評価(Evaluation of the Modifying Effect of Inhalation of Mainstream Cigarette Smoke on Mouse Bladder Carcinogenesis) Reviewed

Kato Minoru, Wei Min, Yamano Shotaro, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会　Journal of Toxicologic Pathology 26 ( 4 ) 447 - 451 2013.12（ ISSN:0914-9198 ）

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タバコ煙吸入曝露システムを用い、膀胱発癌に対するタバコ主流煙吸入の影響を評価した。6週齢雄性C57BLマウス96匹を対照群とタバコ煙曝露群に分け、8週間にわたり飲料水中に0.025%のN-butyl-N-(4-hydroxybutyl)nitrosamine(BBN)を添加して与えた。1週間のウオッシュアウト後、対照群には清浄な空気を、曝露群には300mg/m3のタバコ主流煙を22週間にわたり1週間に5日、1日2時間吸入曝露させた。膀胱腫瘍(乳頭腫および尿路上皮癌)の発生率は、統計的有意差には至らなかったが、対照群(15.8%)よりもタバコ煙曝露群(25.0%)で高かった。膀胱上皮におけるチトクロムP450(CYP)酵素および増殖細胞核抗原(PCNA)のmRNA発現レベルを評価したところ、cyp1a1発現はタバコ煙曝露群で有意に増加したが、cyp1a2、cyp1b1、cyp2a4、cyp2b10、cyp2e1、PCNAの発現には大きな影響を及ぼさなかった。以上から、22週間にわたるタバコ主流煙への限定的曝露によりcyp1a1発現の有意な増加が認められたが、膀胱腫瘍の増加は有意ではなく、膀胱発癌に対するタバコ煙の影響を明らかにするには、より長期の曝露が必要であることが示された。
Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DAN damage in rats Reviewed

Wei Min, Yamada Takanori, Yamano Shotaro, Kato Minoru, Kakehashi Anna, Fujioka Masaki, Tago Yoshiyuki, Kitano Mistuaki, Wanibuchi Hideki

TOXICOLOGY AND APPLIED PHARMACOLOGY 273 ( 1 ) 1 - 9 2013.11（ ISSN:0041-008X ）

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DOI： 10.1016/j.taap.2013.08.022

PubMed
Oxidative stress in the carcinogenicity of chemical carcinogens. Reviewed

Kakehashi A, Wei M, Fukushima S, Wanibuchi H

Cancers 5 ( 4 ) 1332 - 54 2013.10

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DOI： 10.3390/cancers5041332

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Oncomodulin is a novel early marker of urinary bladder carcinogenesis in F344 rats Reviewed

Okumura M., Wei M., Yamano S., Fujioka M., Kakehashi A., Wanibuchi H.

EUROPEAN JOURNAL OF CANCER 49 S198 - S199 2013.09（ ISSN:0959-8049 ）

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L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes Reviewed

Xie Xiao-Li, Kakehashi Anna, Wei Min, Yamano Shotaro, Takeshita Masanori, Yunoki Takayuki, Wanibuchi Hideki

FOOD AND CHEMICAL TOXICOLOGY 59 137 - 144 2013.09（ ISSN:0278-6915 ）

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DOI： 10.1016/j.fct.2013.05.044

PubMed
Twenty-One Proteins Up-Regulated in Human H-ras Oncogene Transgenic Rat Pancreas Cancers are Up-Regulated in Human Pancreas Cancer Reviewed

Yabushita Setsuko, Fukamachi Katsumi, Kikuchi Fumitake, Ozaki Masakazu, Miyata Kaori, Sukata Tokuo, Deguchi Yoshihito, Tanaka Hajime, Kakehashi Anna, Kawamura Satoshi, Uwagawa Satoshi, Wanibuchi Hideki, Suzui Masumi, Alexander David B., Tsuda Hiroyuki

PANCREAS 42 ( 6 ) 1034 - 1039 2013.08（ ISSN:0885-3177 ）

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Twenty-one proteins up-regulated in human H-ras oncogene transgenic rat pancreas cancers are up-regulated in human pancreas cancer. Reviewed

Yabushita S, Fukamachi K, Kikuchi F, Ozaki M, Miyata K, Sukata T, Deguchi Y, Tanaka H, Kakehashi A, Kawamura S, Uwagawa S, Wanibuchi H, Suzui M, Alexander DB, Tsuda H

Pancreas 42 ( 6 ) 1034 - 9 2013.08（ ISSN:0885-3177 ）

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DOI： 10.1097/MPA.0b013e3182883624

PubMed
Clinicopathological significance of combined analysis of cytokeratin19 expression and preoperative serum CYFRA21-1 levels in human lung squamous cell carcinoma. Reviewed

Hanada S, Nishiyama N, Mizuguchi S, Yamano S, Kakehashi A, Wei M, Inoue H, Komatsu H, Chung K, Suehiro S, Wanibuchi H

Osaka city medical journal 59 ( 1 ) 35 - 44 2013.06（ ISSN:0030-6096 ）

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PubMed
ヒト肺扁平上皮がんにおけるサイトケラチン19の発現と術前血清CYFRA21-1濃度の複合分析の臨床病理学的な意義(Clinicopathological Significance of Combined Analysis of Cytokeratin19 Expression and Preoperative Serum CYFRA21-1 Levels in Human Lung Squamous Cell Carcinoma) Reviewed

Hanada Shoji, Nishiyama Noritoshi, Mizuguchi Shinjiro, Yamano Shotaro, Kakehashi Anna, Wei Min, Inoue Hidetoshi, Komatsu Hiroaki, Chung Kyukwang, Suehiro Shigefumi, Wanibuchi Hideki

大阪市医学会　Osaka City Medical Journal 59 ( 1 ) 35 - 44 2013.06（ ISSN:0030-6096 ）

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YT-4-1(YRA) 胃癌幹細胞関連蛋白の同定と臨床的意義(YT Young Researcher Award & Traveler's Grant,第113回日本外科学会定期学術集会) Reviewed

森崎珠実, 八代正和, 渡邊真央, 大北仁裕, 福岡達成, 長谷川毅, 吉井真美, 櫻井克宣, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 梯アンナ, 鰐渕英機, 平川弘聖

一般社団法人日本外科学会　日本外科学会雑誌 114 ( 2 ) 2013.03（ ISSN:18801129 ）

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CiNii Article
Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors Reviewed

Komatsu Hiroaki, Kakehashi Anna, Nishiyama Noritoshi, Izumi Nobuhiro, Mizuguchi Shinjiro, Yamano Shotaro, Inoue Hidetoshi, Hanada Shoji, Chung Kyukwang, Wei Min, Suehiro Shigefumi, Wanibuchi Hideki

CANCER BIOMARKERS 13 ( 3 ) 171 - 180 2013（ ISSN:1574-0153 ）

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DOI： 10.3233/CBM-130336

PubMed
Evaluation of the Modifying Effect of Inhalation of Mainstream Cigarette Smoke on Mouse Bladder Carcinogenesis Reviewed

Kato Minoru, Wei Min, Yamano Shotaro, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会　JOURNAL OF TOXICOLOGIC PATHOLOGY 26 ( 4 ) 447 - 451 2013（ ISSN:0914-9198 ）

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Cigarette smoking is one of the major risk factors of bladder cancer in humans. To date, however, there is no experimental evidence for the effects of inhalation exposure to mainstream cigarette smoke on bladder carcinogenesis. The purpose of the present study was to evaluate the effect of inhalation of mainstream cigarette smoke on mouse bladder carcinogenesis using a cigarette smoke inhalation exposure system. Six-week-old male C57BL mice were administered 0.025% N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in their drinking water for 8 weeks and then divided into 2 groups and exposed to 0 or 300 mg/m3 wet total particulate matter mainstream cigarette smoke for 2 h per day, five times per week, for 22 weeks. The incidences of bladder tumors (papilloma and urothelial carcinoma) tended to increase in the cigarette smoke-exposed group (25.0%) compared with the controls (15.8%), albeit without a statistically significant difference. We also evaluated mRNA expression levels of cytochrome P450 (cyp) enzymes and proliferating cell nuclear antigen (PCNA) in the bladder epithelium. Expression of cyp1a1 was significantly increased in the cigarette smoke-exposed group. Cigarette smoke exposure did not have a significant effect on the expression of cyp1a2, cyp 1b1, cyp 2a4, cyp 2b10, cyp 2e1, or PCNA. In conclusion, limited exposure to mainstream cigarette smoke for 22 weeks, caused a significant increase in cyp1a1 expression. This increase coupled with the nonsignificant increase in bladder tumors suggests that a longer period of exposure is required to clarify the effects of cigarette smoke on bladder carcinogenesis.

DOI： 10.1293/tox.2013-0039

PubMed

CiNii Article
Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma Reviewed

Hanada Shoji, Kakehashi Anna, Nishiyama Noritoshi, Wei Min, Yamano Shotaro, Chung Kyukwang, Komatsu Hiroaki, Inoue Hidetoshi, Suehiro Shigefumi, Wanibuchi Hideki

CANCER BIOMARKERS 13 ( 4 ) 289 - 298 2013（ ISSN:1574-0153 ）

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DOI： 10.3233/CBM-130354

PubMed
Dammar resin, a non-mutagen, induces oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline (vol 748, pg 29, 2012) Reviewed

Xie Xiao-Li, Wei Min, Kakehashi Anna, Yamano Shotaro, Okabe Kyoko, Tajiri Masaki, Wanibuchi Hideki

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 749 ( 1-2 ) 105 - 105 2012.12（ ISSN:1383-5718 ）

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DOI： 10.1016/j.mrgentox.2012.08.004
Threshold for Genotoxic Carcinogens : The Central Concern in Carcinogenic Risk Assessment Reviewed

Fukushima Shoji, Wei Min, Kakehashi Anna, WANIBUCHI Hideki

日本環境変異原学会　Genes and environment : the official journal of the Japanese Environmental Mutagen Society 34 ( 4 ) 153 - 156 2012.11（ ISSN:18807046 ）

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To verify scientifically whether the non-threshold concept of genotoxic carcinogenicity is valid, we examined the hepatocarcinogenicities at low doses of three genotoxic carcinogens: 2-amino-3, 8 dimethylimidazo[4,5-f]quinoxaline (MeIQx), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and N-nitrosodiethylamine (DEN) using a medium-term rat hepatocarcinogenicity bioassay. We also examined alterations of molecular markers that cells typically acquire as they move through the initiation and promotion stages of carcinogenesis. We found that low doses of MeIQx induced formation of DNA-MeIQx adducts, somewhat higher doses caused elevation of oxidative DNA damage, at further higher doses gene mutations occurred; and the very highest dose of MeIQx induced formation of glutathione S-transferase placental form (GST-P) positive foci in the liver, a well-known preneoplastic lesion marker in rat hepatocarcinogenesis. Similarly, low doses of IQ and DEN had no effect on formation of GST-P positive foci in the rat liver. Furthermore, we demonstrated that concurrent treatment with combinations of sub-carcinogenic doses of MeIQx and DEN were not hepatocarcinogenic and the combined effects were neither additive nor synergistic. Moreover, concurrent treatment with low carcinogenic doses of these 2 carcinogens did not show additive or synergistic effects, and synergetic effects were observed only in rats co-administered high doses of those 2 carcinogens. These findings demonstrated the existence of no effect levels for these genotoxic hepatocarcinogens, and suggested that there is a threshold, at least a practical threshold, that should be considered when evaluating the risk of exposure to genotoxic carcinogens. 

DOI： 10.3123/jemsge.34.153

CiNii Article
Long-term treatment with L-isoleucine or L-leucine in AIN-93G diet has promoting effects on rat bladder carcinogenesis Reviewed

Xie Xiao-Li, Wei Min, Yunoki Takayuki, Kakehashi Anna, Yamano Shotaro, Kato Minoru, Wanibuchi Hideki

FOOD AND CHEMICAL TOXICOLOGY 50 ( 11 ) 3934 - 3940 2012.11（ ISSN:0278-6915 ）

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DOI： 10.1016/j.fct.2012.07.063

PubMed
Dammar resin, a non-mutagen, inducts oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline Reviewed

Xie Xiao-Li, Wei Min, Kakehashi Anna, Yamano Shotaro, Okabe Kyoko, Tajiri Masaki, Wanibuchi Hideki

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS 748 ( 1-2 ) 29 - 35 2012.10（ ISSN:1383-5718 ）

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DOI： 10.1016/j.mrgentox.2012.06.005

PubMed
ラットにおける低用量の2-amino-3,8-dimethylimidazo[4,5-f]quinoxalineとdiethylnitrosamineの混合による肝発癌性の欠如　遺伝毒性発癌物質に対する閾値の存在に関する示唆(Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens) Reviewed

Wei Min, Kakehashi Anna, Yamano Shotaro, Tamano Seiko, Shirai Tomoyuki, Wanibuchi Hideki, Fukushima Shoji

日本毒性病理学会　Journal of Toxicologic Pathology 25 ( 3 ) 209 - 214 2012.09（ ISSN:0914-9198 ）

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ラットにて、2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline(MeIQx)とdiethylnitrosamine(DEN)の同時投与の肝発癌性を検討し、この組み合わせの無効果レベルが存在するかを調べた。実験1では、種々の用量のMeIQxで誘導の肝発癌に及ぼす発癌下用量のDEN同時投与を評価した。また、実験2では、発癌下、低発癌、高発癌用量のMeIQxとDENの組み合わせの肝発癌性を検討した。実験1で、DENはMeIQxの肝発癌性を増強せず、実験2では、発癌下用量の組み合わせでの肝発癌は見られず、発癌下用量のDENとMeIQxの組み合わせ効果は、相加的でも相乗的でもなかった。さらに低用量の組み合わせは、相加的・相乗的効果を示さず、高用量の同時投与で相乗効果が見られた。これらの結果は、この2つの肝発癌物質の組み合わせに無効果レベルのがあることを示した。
Methionine Sulfoxide Stimulates Hepatocarcinogenesis in Non-alcoholic Steatohepatitis (NASH) Mouse : Possible Role of Free Radical-mediated DNA Methylation Reviewed

Kawai Kazuaki, Li Yun-Shan, Song Ming-Fen, OOTSUYAMA Yuko, KAKEHASHI Anna, WANIBUCHI Hideki, OOTSUYAMA Akira, NORIMURA Toshiyuki, KASAI Hiroshi

日本環境変異原学会　Genes and environment : the official journal of the Japanese Environmental Mutagen Society 34 ( 3 ) 123 - 128 2012.08（ ISSN:18807046 ）

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We have reported the formation of 5-methylcytosine from cytosine in vitro, with methyl radicals generated from methionine sulfoxide (MetO). To confirm this reaction in vivo, MetO was added to the drinking water and administered to non-alcoholic steatohepatitis (NASH) mice, which develop hepatitis caused by endogenous oxidative stress. Histopathological examinations revealed incidences of hepatocellular carcinoma of 16.7% and 90% in the 0% and 3% MetO groups, respectively. Higher DNA methylation was detected in the promoter region of the p16 gene isolated from the livers of MetO-treated mice. The higher incidence of liver tumors may be due to the methyl radical-mediated formation of 5-methylcytosine in DNA, which triggers epigenetic changes. 

DOI： 10.3123/jemsge.34.123

CiNii Article
DDX39 acts as a suppressor of invasion for bladder cancer Reviewed

Kato Minoru, Wei Min, Yamano Shotaro, Kakehashi Anna, Tamada Satoshi, Nakatani Tatsuya, Wanibuchi Hideki

CANCER SCIENCE 103 ( 7 ) 1363 - 1369 2012.07（ ISSN:1349-7006 ）

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DOI： 10.1111/j.1349-7006.2012.02298.x

PubMed
AGR2 as a Potential Biomarker of Human Lung Adenocarcinoma Reviewed

Chung Kyukwang, Nishiyama Noritoshi, Wanibuchi Hideki, Yamano Shotaro, Hanada Shoji, Wei Min, Suehiro Shigefumi, Kakehashi Anna

大阪市立大学　Osaka City Medical journal 58 ( 1 ) 13 - 24 2012.06（ ISSN:00306096 ）

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CiNii Article
ヒト肺腺癌のバイオマーカーとなり得るAGR2(AGR2 as a Potential Biomarker of Human Lung Adenocarcinoma) Reviewed

Chung Kyukwang, Nishiyama Noritoshi, Wanibuchi Hideki, Yamano Shotaro, Hanada Shoji, Wei Min, Suehiro Shigefumi, Kakehashi Anna

大阪市医学会　Osaka City Medical Journal 58 ( 1 ) 13 - 24 2012.06（ ISSN:0030-6096 ）

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臨床使用と治療に有用な肺腺癌のバイオマーカーを同定するため、肺腺癌患者12名を対象に、液体クロマトグラフィー(LC)/タンデム質量分析(MS)を用いて過剰発現タンパク質を隣接の正常組織と比較した。12名中9名以上の肺腺癌患者で、177種のタンパク質が同定された。LC/タンデムMS、Ingenuity Pathway、免疫組織化学分析の結果に基づき、AGR2(anterior gradient homolog 2)が肺腺癌のバイオマーカーとして選別された。AGR2は肺腺癌患者の94%で陽性であった。負のAGR2発現は生存不良と関連した。AGR2はバイオマーカーとして臨床適用できる。
AGR2 as a potential biomarker of human lung adenocarcinoma. Reviewed

Chung K, Nishiyama N, Wanibuchi H, Yamano S, Hanada S, Wei M, Suehiro S, Kakehashi A

Osaka city medical journal 58 ( 1 ) 13 - 24 2012.06（ ISSN:0030-6096 ）

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PubMed
Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis Reviewed

Nakatani Shinya, Wei Min, Ishimura Eiji, Kakehashi Anna, Mori Katsuhito, Nishizawa Yoshiki, Inaba Masaaki, Wanibuchi Hideki

NEPHROLOGY DIALYSIS TRANSPLANTATION 27 ( 5 ) 1889 - 1897 2012.05（ ISSN:0931-0509 ）

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DOI： 10.1093/ndt/gfr682

PubMed
Comparison proteome analysis of scirrhous gastric carcinoma stem cell-like SP and hypoxia-resistant cell lines Reviewed

Morisaki Tamami, Yashiro Masakazu, Kakehashi Anna, Okita Yoshihiro, Fukuoka Tatsunari, Aomatsu Naoki, Yoshii Mami, Hasegawa Tsuyoshi, Matsuoka Junko, Nagahara Hisashi, Kimura Kenjiro, Noda Eiji, Amano Ryosuke, Kubo Naoshi, Tanaka Hiroaki, Muguruma Kazuya, Yamada Nobuya, Maeda Kiyoshi, Nakata Bunzo, Ohira Masaichi, Wanibuchi Hideki, Hirakawa Kosei

CANCER RESEARCH 72 2012.04（ ISSN:0008-5472 ）

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DOI： 10.1158/1538-7445.AM2012-3380
Hormonally Active Doses of Isoflavone Aglycones Promote Mammary and Endometrial Carcinogenesis and Alter the Molecular Tumor Environment in Donryu Rats Reviewed

Kakehashi Anna, Tago Yoshiyuki, Yoshida Midori, Sokuza Yui, Wei Min, Fukushima Shoji, Wanibuchi Hideki

TOXICOLOGICAL SCIENCES 126 ( 1 ) 39 - 51 2012.03（ ISSN:1096-6080 ）

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DOI： 10.1093/toxsci/kfs016

PubMed
2-Amino-3-Methylimidazo[4,5-f]Quinoline (IQ) Promotes Mouse Hepatocarcinogenesis by Activating Transforming Growth Factor-beta and Wnt/beta-Catenin Signaling Pathways Reviewed

Xie Xiao-Li, Wei Min, Kakehashi Anna, Yamano Shotaro, Tajiri Masaki, Wanibuchi Hideki

TOXICOLOGICAL SCIENCES 125 ( 2 ) 392 - 400 2012.02（ ISSN:1096-6080 ）

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DOI： 10.1093/toxsci/kfr314

PubMed
Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens Reviewed

Wei Min, Kakehashi Anna, Yamano Shotaro, Tamano Seiko, Shirai Tomoyuki, Wanibuchi Hideki, Fukushima Shoji

日本毒性病理学会　JOURNAL OF TOXICOLOGIC PATHOLOGY 25 ( 3 ) 209 - 214 2012（ ISSN:0914-9198 ）

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The purposes of the present study were to evaluate the hepatocarcinogenicity of concurrent treatment of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) and diethylnitrosamine (DEN) in rats and to determine whether no effect levels of combinations of these two different structural categories of genotoxic hepatocarcinogens exist. Two 16-week rat hepatocarcinogenesis assays were performed using a total of 790 male F344 rats. In experiment 1, we evaluated the effects of concurrent treatment of a subcarcinogenic dose of DEN on rat hepatocarcinogenesis induced by various doses of MeIQx. In experiment 2, we determined hepatocarcinogenicities of combinations of MeIQx and DEN at subcarcinogenic doses, low carcinogenic doses and high carcinogenic doses. Quantitative analyses of glutathione S-transferase placental form (GST-P)-positive foci, a preneoplastic lesion of the liver in rats, revealed that concurrent treatment with subcarcinogenic doses of DEN did not enhance MeIQx-induced rat hepatocarcinogenicity. We also found that concurrent treatment with combinations of subcarcinogenic doses of DEN and MeIQx was not hepatocarcinogenic, indicating that the combined effects of subcarcinogenic doses of DEN and MeIQx were neither additive nor synergistic. Moreover, concurrent treatment with low carcinogenic doses of these 2 carcinogens did not show additive or synergistic effects. Synergetic effects were observed only in rats coadministered high carcinogenic doses of the 2 carcinogens. These results demonstrate the existence of no effect levels of combinations of these 2 genotoxic hepatocarcinogens, and provide new evidence supporting our idea that there is a threshold, at least a practical threshold, that should be considered when evaluating the risk of genotoxic carcinogens.

DOI： 10.1293/tox.25.209

PubMed

CiNii Article
Low-dose carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in rats: Evidence for the existence of no-effect levels and a mechanism involving p21(Cip/WAF1) Reviewed

Wei Min, Kakehashi Anna, Yamano Shotaro, Fukushima Shoji, Wanibuchi Hideki

CANCER RESEARCH 71 2011.04（ ISSN:0008-5472 ）

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DOI： 10.1158/1538-7445.AM2011-5553
Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay : Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis Reviewed

ISHII Naomi, WEI Min, KAKEHASHI Anna, DOI Kenichiro, YAMANO Shotaro, INABA Masaaki, WANIBUCHI Hideki

Journal of toxicologic pathology 24 ( 1 ) 25 - 36 2011.03（ ISSN:09149198 ）

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CiNii Article
Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer Reviewed

Hoshi Hirotaka, Sawada Tetsuji, Uchida Motoyuki, Saito Hikaru, Iijima Hiroko, Toda-Agetsuma Mikako, Wada Tsutomu, Yamazoe Sadaaki, Tanaka Hiroaki, Kimura Kenjiro, Kakehashi Anna, Wei Min, Hirakawa Kosei, Wanibuchi Hideki

INTERNATIONAL JOURNAL OF ONCOLOGY 38 ( 3 ) 619 - 627 2011.03（ ISSN:1019-6439 ）

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DOI： 10.3892/ijo.2011.911

PubMed
Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of Kojic acid in F344 rats Reviewed

Chusiri Yaowares, Wongpoomchai Rawiwan, Kakehashi Anna, Wei Min, Wanibuchi Hideki, Vinitketkumnuan Usanee, Fukushima Shoji

FOOD AND CHEMICAL TOXICOLOGY 49 ( 2 ) 471 - 476 2011.02（ ISSN:0278-6915 ）

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DOI： 10.1016/j.fct.2010.11.027

PubMed
Mitochondrial Prohibitins and Septin 9 Are Implicated in the Onset of Rat Hepatocarcinogenesis Reviewed

Kakehashi Anna, Ishii Naomi, Shibata Takeshi, Wei Min, Okazaki Etsuko, Tachibana Taro, Fukushima Shoji, Wanibuchi Hideki

TOXICOLOGICAL SCIENCES 119 ( 1 ) 61 - 72 2011.01（ ISSN:1096-6080 ）

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DOI： 10.1093/toxsci/kfq307

PubMed
Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy Reviewed

Nakatani Shinya, Kakehashi Anna, Ishimura Eiji, Yamano Shotaro, Mori Katsuhito, Wei Min, Inaba Masaaki, Wanibuchi Hideki

EXPERIMENTAL DIABETES RESEARCH 2011 979354 2011（ ISSN:1687-5214 ）

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DOI： 10.1155/2011/979354

PubMed
Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma Reviewed

Chung Kyukwang, Nishiyama Noritoshi, Yamano Shotaro, Komatsu Hiroaki, Hanada Shoji, Wei Min, Wanibuchi Hideki, Suehiro Shigefumi, Kakehashi Anna

CANCER BIOMARKERS 10 ( 2 ) 101 - 107 2011（ ISSN:1574-0153 ）

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DOI： 10.3233/CBM-2012-0234

PubMed
Existence of a threshold for genotoxic carcinogens Reviewed

WEI MIN, KAKEHASHI ANNA, FUKUSHIMA SHOJI, WANIBUCHI HIDEKI

The Japanese Society of Toxicology, Annual Meeting of the Japanese Society of Toxicology 38 ( 0 ) 184 - 184 2011

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DOI： 10.14869/toxp.38.0.184.0

CiNii Article
Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis Reviewed

Ishii Naomi, Wei Min, Kakehashi Anna, Doi Kenichiro, Yamano Shotaro, Inaba Masaaki, Wanibuchi Hideki

日本毒性病理学会　JOURNAL OF TOXICOLOGIC PATHOLOGY 24 ( 1 ) 25 - 35 2011（ ISSN:0914-9198 ）

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In the present study, modifying effects of diabetes on carcinogenesis induced in type 2 diabetes mellitus model Zucker diabetic fatty (ZDF) rats were investigated using a multiorgan carcinogenesis bioassay. Our results demonstrated enhancement of urinary bladder, colon and liver carcinogenesis in ZDF rats treated with five types of carcinogens (DMBDD). Elevated insulin and leptin and decreased adiponectin levels in the serum may be responsible for the high susceptibility of type 2 diabetes mellitus model rats to carcinogenesis in these organs. Possible mechanisms of increased susceptibility of diabetic rats to bladder carcinogenesis could be activation of the PI3K pathway and suppression of p53 in the urothelium in consequence of the above serum protein alterations.

DOI： 10.1293/tox.24.25

PubMed

CiNii Article
Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats. Reviewed

Tago Y, Wei M, Ishii N, Kakehashi A, Wanibuchi H

日本毒性病理学会　Journal of toxicologic pathology 23 ( 4 ) 245 - 51 2010.12（ ISSN:0914-9198 ）

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Equisetum arvense, commonly known as the field horsetail, has potential as a new functional food ingredient. However, little information is available on its side effects, and the general toxicity of Equisetum arvense has yet to be examined in detail. In the present study, we evaluated the influence of administration in diet at doses of 0, 0.3, 1 and 3% for 13 weeks in male and female F344 rats. No toxicity was detected with reference to clinical signs, body weight, urinalysis, hematology and serum biochemistry data and organ weights. Microscopic examination revealed no histopathological lesions associated with treatment. In conclusion, the no-observed-adverse-effect level (NOAEL) for Equisetum arvense was determined to be greater than 3% in both sexes of F344 rat (males and females: >1.79 g/kg BW/day and >1.85 g/kg BW/day, respectively) under the conditions of the present study. 

DOI： 10.1293/tox.23.245

PubMed

CiNii Article
F344ラットにおける食餌中投与されたEquisetum arvenseの亜慢性毒性の評価(Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats) Reviewed

Tago Yoshiyuki, Wei Min, Ishii Naomi, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会　Journal of Toxicologic Pathology 23 ( 4 ) 245 - 251 2010.12（ ISSN:0914-9198 ）

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一般にスギナとして知られているE.arvenseは、新規の機能性食品材料になる可能性がある。しかし、その副作用に関する情報は殆んど利用できず、全身毒性に関しても詳しく調べられていない。F344雌雄ラットに、E.arvenseを食餌に0、0.3、1、3%混ぜて13週間与え、その毒性を検討した。臨床徴候、体重、尿検査データ、血液および血清生化学データ、臓器重量に関して、毒性は全く検出されなかった。顕微鏡検査で、処置関連組織病理学的病変は認められなかった。F344雌雄ラットにおいて、E.arvenseの無毒性量は3%以上である(雄では>1.79g/kg体重/日、雌では>1.85g/kg体重/日)。
Rat Monoclonal Antibody Specific for Septin 9 Reviewed

Tachibana Taro, Okazaki Etsuko, Yoshimi Tomohiko, Azuma Masayuki, Kakehashi Anna, Wanibuchi Hideki

HYBRIDOMA 29 ( 2 ) 169 - 171 2010.04（ ISSN:1554-0014 ）

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DOI： 10.1089/hyb.2009.0092

PubMed
Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions Reviewed

Kakehashi Anna, Kato Ayumi, Inoue Masayo, Ishii Naomi, Okazaki Etsuko, Wei Min, Tachibana Taro, Wanibuchi Hideki

TOXICOLOGY AND APPLIED PHARMACOLOGY 242 ( 1 ) 47 - 55 2010.01（ ISSN:0041-008X ）

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DOI： 10.1016/j.taap.2009.09.013

PubMed
Sensitive quantitative assay for point mutations in the rat H-ras gene based on single nucleotide primer extension Reviewed

Yano Yoshihisa, Yano Tomohiro, Kinoshita Anna, Matoba Ai, Hasuma Tadayoshi, Wanibuchi Hideki, Morimura Keiichirou, Otani Shuzo, Fukushima Shoji

EXPERIMENTAL AND THERAPEUTIC MEDICINE 1 ( 4 ) 657 - 661 2010（ ISSN:1792-0981 ）

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DOI： 10.3892/etm_00000103

PubMed
Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats Reviewed

Tago Yoshiyuki, Wei Min, Ishii Naomi, Kakehashi Anna, Wanibuchi Hideki

JOURNAL OF TOXICOLOGIC PATHOLOGY 23 ( 4 ) 245 - 251 2010（ ISSN:0914-9198 ）

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Potassium Bromate Enhances N-Ethyl-N-Hydroxyethylnitrosamine-Induced Kidney Carcinogenesis Only at High Doses in Wistar Rats: Indication of the Existence of an Enhancement Threshold Reviewed

Wei Min, Hamoud Al-Salmy, Yamaguchi Takashi, Kakehashi Anna, Marimura Keiichirou, Doi Kenichiro, Kushida Masahiko, Kitano Mitsuaki, Wanibuchi Hideki, Fukushima Shoji

TOXICOLOGIC PATHOLOGY 37 ( 7 ) 983 - 991 2009.12（ ISSN:0192-6233 ）

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DOI： 10.1177/0192623309351720

PubMed
Characteristic upregulation of glucose-regulated protein 78 in an early lesion negative for hitherto established cytochemical markers in rat hepatocarcinogenesis. Reviewed

Sukata T, Uwagawa S, Ozaki K, Sumida K, Kushida M, Kakehashi A, Wanibuchi H, Miyata K, Ogata K, Fukushima S

日本毒性病理学会　Journal of toxicologic pathology 22 ( 4 ) 281 - 8 2009.12（ ISSN:0914-9198 ）

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Previously, we reported α2-macroglobulin (α2M) to be a novel marker characteristic of rat hepatocellular preneoplastic and neoplastic lesions negative for hitherto well-established markers. In the present study, we further examined other candidate markers with specificity for the same type of lesions. Glutathione S-transferase-placental form (GST-P)-negative hepatocellular altered foci (HAF) were generated using a two-stage (initiation and promotion) carcinogenesis protocol with N,N-diethylnitrosamine (DEN) and either Wy-14,643 or clofibrate, two peroxisome proliferators. Microarray analysis using total RNAs isolated from laser-microdissected GST-P-negative HAF (amphophilic cell foci) and adjacent normal tissues was conducted along with immunohistochemistry and real-time RT-PCR. Staining for glucose-regulated protein 78 (GRP78) was detected in GST-P-negative HAF and hepatocellular adenomas, and slightly increased GRP78 mRNA expression was observed in the lesions by real-time RT-PCR analysis. Thus, an early increase of GRP78 expression in hepatocarcinogenesis is likely a feature of the amphophilic subset of HAF. 

DOI： 10.1293/tox.22.281

PubMed

CiNii Article
Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident Reviewed

Romanenko Alina, Kakehashi Anna, Morimura Keiichirou, Wanibuchi Hideki, Wei Min, Vozianov Alexander, Fukushima Shoji

CARCINOGENESIS 30 ( 11 ) 1821 - 1831 2009.11（ ISSN:0143-3334 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1093/carcin/bgp193

PubMed
Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas Reviewed

Kakehashi Anna, Inoue Masayo, Wei Min, Fukushima Shoji, Wanibuchi Hideki

TOXICOLOGY AND APPLIED PHARMACOLOGY 238 ( 1 ) 71 - 79 2009.07（ ISSN:0041-008X ）

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DOI： 10.1016/j.taap.2009.04.018

PubMed
Existence of a Threshold for the Genotoxic Carcinogens : Evidence from Mechanism-based Carcinogenicity Studies Reviewed

Fukushima Shoji, Kakehashi Anna, Wei Min, WANIBUCHI Hideki

日本環境変異原学会　Genes and environment : the official journal of the Japanese Environmental Mutagen Society 31 ( 2 ) 33 - 36 2009.05（ ISSN:18807046 ）

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The hepatocarcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), a carcinogen contained in fried meat and fish, was examined in the medium-term rat liver carcinogenicity bioassay. Induction of DNA-MeIQx adducts occurred with low doses of the chemical, followed by increasing doses by elevation of 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in DNA and lacI gene mutations, which might have been related to the initiation of carcinogenesis by MeIQx. Further elevation of the MeIQx dose was shown to cause the formation of glutathione S-transferase placental form (GST-P) positive foci in the liver, a well-known preneoplastic marker in rat hepatocarcinogenesis. In studies with N-nitrosocompounds such as N-nitrosodiethylamine and N-nitrosodimethylamine, no induction of GST-P positive foci was observed after their administration at low doses. When the carcinogenicity of a well-known colon carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) was examined, PhIP-DNA adduct formation was observed after treatment with low doses, while only high doses of the chemical were found to induce aberrant crypt foci (ACF), which are a surrogate marker of preneoplastic lesions in the colon. In experiments with potassium bromate, carcinogenicity, mutagenicity, and 8-OHdG formation in the rat kidney were observed only after administration at high dose. From these results, the genotoxic carcinogens were concluded to have a threshold, at least practical, with respect to their carcinogenicity. 

DOI： 10.3123/jemsge.31.33

CiNii Article
Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker. Reviewed

Kushida M, Wanibuchi H, Wei M, Kakehashi A, Ozaki K, Sukata T, Miyata K, Ogata K, Uwagawa S, Fukushima S

日本毒性病理学会　Journal of toxicologic pathology 22 ( 1 ) 65 - 70 2009.03（ ISSN:0914-9198 ）

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Epidemiological studies suggest that alcohol consumption increases the risk of developing colorectal cancer. However, the data are confounded by numerous cosegregating variables. To cast further light on the relationships between alcohol intake and colon cancer development, 21-day-old male F344/DuCrj rats were fed 200 ppm 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in their diet for 8 weeks and doses of 0, 0.1, 0.3, 1, 3, 10 and 20% of ethanol in their drinking water ad libitum for 16 weeks thereafter. The rats were sacrificed after 24 weeks of experiment, and aberrant crypt foci (ACF), surrogate lesions for colon cancer, were examined under a light microscope at low magnification. Ethanol was found not to affect the ACF formation at any dose compared with the initiated-controls. Furthermore, ethanol did not alter colon epithelial cell proliferation. These data, obtained by analysis of a colon cancer surrogate marker lesion, indicate that ethanol lacks promotion activity for MeIQx-initiated rat colon carcinogenesis. 

DOI： 10.1293/tox.22.65

PubMed

CiNii Article
Characteristic Upregulation of Glucose-Regulated Protein 78 in an Early Lesion Negative for Hitherto Established Cytochemical Markers in Rat Hepatocarcinogenesis Reviewed

Sukata Tokuo, Uwagawa Satoshi, Ozaki Keisuke, Sumida Kayo, Kushida Masahiko, Kakehashi Anna, Wanibuchi Hideki, Miyata Kaori, Ogata Keiko, Fukushima Shoji

JOURNAL OF TOXICOLOGIC PATHOLOGY 22 ( 4 ) 281 - 288 2009（ ISSN:0914-9198 ）

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Ethanol Does Not Promote MeIQx-initiated Rat Colon Carcinogenesis Based on Evidence from Analysis of a Colon Cancer Surrogate Marker Reviewed

Kushida Masahiko, Wanibuchi Hideki, Wei Min, Kakehashi Anna, Ozaki Keisuke, Sukata Tokuo, Miyata Kaori, Ogata Keiko, Uwagawa Satoshi, Fukushima Shoji

JOURNAL OF TOXICOLOGIC PATHOLOGY 22 ( 1 ) 65 - 70 2009（ ISSN:0914-9198 ）

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Are there thresholds for carcinogens carcinogenicity? Reviewed

FUKUSHIMA Shoji, WEI Min, KAKEHASHI Anna, WANIBUCHI Hideki

Japanese Society of Mycotoxicology, JSM Mycotoxins 58 ( 2 ) 119 - 128 2008.07（ ISSN:02851466 ）

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Publishing type：Research paper (scientific journal)

A food-derived, genotoxic hepatocarcinogen, 2-amino-3,8-dimethylimidazo[4,5-f ] quinoxaline (MeIQx) low-dose carcinogenicity was examined in the rat liver using a medium term bioassay for carcinogens. MeIQx was shown to form DNA adducts at very low doses, but did not induce 8-hydroxy-2′-deoxyguanosine formations, lacI gene mutations or an initiation activity. Glutathione S-transferase placental form (GST-P)-positive foci which are preneoplastic lesions occurred at higher dose. Furthermore, N-nitroso compounds, such as N-nitrosodiethylamine and N-nitrosodimethylamine were found not to induce GST-P-positive foci in the rat liver at very low doses. A genotoxic colon carcinogen, 2-amino-1-methyl-6-phenolimidazo [4,5-b] pyridine (PhIP) induced PhIP-DNA adducts at very low dose with no-effect level and aberrant crypt foci as a surrogate marker of preneoplastic lesions appeared at relatively high doses.These results imply the existence of thresholds, at least practical ones for the carcinogenicities of these genotoxic carcinogens. A non-genotoxic carcinogen, phenobarbital showed hormetic phenomenon in rat hepatocarcinogenicity, indicating the real threshold for the carcinogenicity.

DOI： 10.2520/myco.58.119

CiNii Article
Chemopreventive effects of a serratane-type triterpenoid, 3 alpha-methoxyserrat-14-en-21 beta-ol (PJ-1), against rat lung carcinogenesis Reviewed

Yamaguchi Chiharu, Wanibuchi Hideki, Kakehashi Anna, Tanaka Reiko, Fukushima Shoji

FOOD AND CHEMICAL TOXICOLOGY 46 ( 6 ) 1882 - 1888 2008.06（ ISSN:0278-6915 ）

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DOI： 10.1016/j.fct.2007.12.018

PubMed
食品などに含まれる発がん物質に閾値が存在するのか Reviewed

梯アンナ

食衛誌 49 2008

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Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder Reviewed

Kinoshita Anna, Wanibuchi Hideki, Wei Min, Yunokl Takayuki, Fukushima Shoji

TOXICOLOGY AND APPLIED PHARMACOLOGY 221 ( 3 ) 295 - 305 2007.06（ ISSN:0041-008X ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.taap.2007.03.024

PubMed
Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice Reviewed

Kinoshita Anna, Wanibuchi Hideki, Morimura Keiichirou, Wei Min, Nakae Dai, Arai Tsuyoshi, Minowa Osamu, Noda Tetsuo, Nishimura Susumu, Fukushima Shoji

CANCER SCIENCE 98 ( 6 ) 803 - 814 2007.06（ ISSN:1347-9032 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1349-7006.2007.00475.x

PubMed
Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis Reviewed

Kang Jin Seok, Wanibuchi Hideki, Murai Takashi, Morimura Keiichirou, Kinoshita Anna, Fukushima Shoji

ONCOLOGY REPORTS 17 ( 4 ) 747 - 752 2007.04（ ISSN:1021-335X ）

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Publishing type：Research paper (scientific journal)
Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats Reviewed

Kang Jin Seok, Wanibuchi Hideki, Salim Elsayed I., Kinoshita Anna, Fukushima Shoji

FOOD AND CHEMICAL TOXICOLOGY 45 ( 3 ) 494 - 501 2007.03（ ISSN:0278-6915 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.fct.2006.09.013

PubMed
Carcinogenicity of dimethylarsinic acid in Ogg1-deficient mice

Cancer Science 98 ( 6 ) 803 - 814 2007

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Publishing type：Research paper (scientific journal)
Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder

Toxicol Appl Pharmacol 221 ( 3 ) 295 - 305 2007

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Publishing type：Research paper (scientific journal)
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident Reviewed

Romanenko Alina M., Morimura Keiichirou, Kinoshita Anna, Wanibuchi Hideki, Takahashi Satoru, Zaparin Wadim K., Vinnichenko Wladimir I., Vozianov Alexander F., Fukushima Shoji

CANCER SCIENCE 97 ( 11 ) 1168 - 1174 2006.11（ ISSN:1349-7006 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1349-7006.2006.00309.x

PubMed
Hormesis in Carcinogenicity of Non-genotoxic Carcinogens Reviewed

KINOSHITA Anna, WANIBUCHI Hideki, WEI Min, FUKUSHIMA Shoji

日本毒性病理学会　Journal of toxicologic pathology 19 ( 3 ) 111 - 122 2006.09（ ISSN:0914-9198 ）

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Recently the idea of hormesis, a biphasic dose-response relationship in which a chemical exerts opposite effects dependent on the dose, has attracted interest in the field of carcinogenesis. With non-genotoxic agents there is considerable experimental evidence in support of hormesis and the present review highlights current knowledge of dose-response effects. In particular, several in vivo studies have provided support for the idea that non-genotoxic carcinogens may inhibit hepatocarcinogenesis at low doses. Here, we survey the examples and discuss possible mechanisms of hormesis with cytochrome P450 inducers, such as phenobarbital, 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), α-benzene hexachloride (α-BHC), and other non-genotoxins. Epigenetic processes differentially can be affected by agents that impinge on oxidative stress, DNA repair, cell proliferation, apoptosis, intracellular communication and cell signaling. Non-genotoxic carcinogens may target nuclear receptors, cause aberrant DNA methylation at the genomic level and induce post-translational modifications at the protein level, thereby impacting on the stability or activity of key regulatory proteins, including oncoproteins and tumor suppressor proteins. Via multiple epigenetic lesions, non-genotoxic carcinogens can elicit a variety of changes contributing to cellular carcinogenesis.

DOI： 10.1293/tox.19.111

CiNii Article
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes Reviewed

Puatanachokchai Rawiwan, Morimura Keiichirou, Wanibuchi Hideki, Oka Mayuko, Kinoshita Anna, Mitsuru Fukui, Yamaguchi Shuji, Funae Yoshihiko, Fukushima Shoji

CANCER LETTERS 240 ( 1 ) 102 - 113 2006.08（ ISSN:0304-3835 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.canlet.2005.09.006

PubMed
N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage Reviewed

Nishikawa-Ogawa M, Wanibuchi H, Morimura K, Kinoshita A, Nishikawa T, Hayashi S, Yano Y, Fukushima S

CARCINOGENESIS 27 ( 5 ) 982 - 988 2006.05（ ISSN:0143-3334 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1093/carcin/bgi277

PubMed
Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice. Reviewed

Puatanachokchai R, Kakuni M, Wanibuchi H, Kinoshita A, Kang JS, Salim EI, Morimura K, Tamano S, Merlino GT, Fukushima S

Asian Pacific journal of cancer prevention : APJCP 7 ( 2 ) 274 - 8 2006.04（ ISSN:1513-7368 ）

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PubMed
A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response Reviewed

Shen J, Wanibuchi H, Waalkes MP, Salim EI, Kinoshita A, Yoshida K, Endo G, Fukushima S

TOXICOLOGY AND APPLIED PHARMACOLOGY 210 ( 3 ) 171 - 180 2006.02（ ISSN:0041-008X ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.taap.2005.04.018

PubMed
Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans Reviewed

Romanenko AM, Kinoshita A, Wanibuchi H, Wei M, Zaparin WK, Vinnichenko WI, Vozianov AF, Fukushima S

JOURNAL OF UROLOGY 175 ( 2 ) 739 - 743 2006.02（ ISSN:0022-5347 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/S0022-5347(05)00172-2

PubMed
Aberrant expression of E-cadherin and beta-catenin in association with transforming growth factor-beta 1 in urinary bladder lesions in humans after the Chernobyl accident Reviewed

Romanenko A, Morimura K, Kinoshita A, Wanibuchi H, Vozianov A, Fukushima S

CANCER SCIENCE 97 ( 1 ) 45 - 50 2006.01（ ISSN:1347-9032 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1349-7006.2005.00131.x

PubMed
Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470. Reviewed

Wanibuchi H, Wei M, Salim EI, Kinoshita A, Morimura K, Sudo K, Fukushima S

Asian Pacific journal of cancer prevention : APJCP 7 ( 1 ) 101 - 7 2006.01（ ISSN:1513-7368 ）

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PubMed
Effects of cessation of alcohol exposure on rat hepatocarcinogenesis. Reviewed

Wanibuchi H, Zhang Y, Kinoshita A, Wei M, Kang JS, Fukushima S

Asian Pacific journal of cancer prevention : APJCP 7 ( 1 ) 122 - 6 2006.01（ ISSN:1513-7368 ）

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Publishing type：Research paper (scientific journal)

PubMed
Existence of no hepatocarcinogenic effect levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without coadministration with ethanol Reviewed

Wanibuchi Hideki, Wei Min, Karim M. Rezaul, Morimura Keiichirou, Doi Kenichiro, Kinoshita Anna, Fukushima Shoji

TOXICOLOGIC PATHOLOGY 34 ( 3 ) 232 - 236 2006（ ISSN:0192-6233 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1080/01926230600713632

PubMed
Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf-1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident.

97 1168 - 1174 2006

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Publishing type：Research paper (scientific journal)
Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans.

J. Urology 175 ( 2 ) 739 - 743 2006

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Publishing type：Research paper (scientific journal)
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: Possible mechanisms Reviewed

Kushida M, Sukata T, Uwagawa S, Ozaki K, Kinoshita A, Wanibuchi H, Morimura K, Okuno Y, Fukushima S

TOXICOLOGY AND APPLIED PHARMACOLOGY 208 ( 3 ) 285 - 294 2005.11（ ISSN:0041-008X ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.taap.2005.03.018

PubMed
Dose-dependence of promotion of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis by ethanol: Evidence for a threshold Reviewed

Kushida M, Wanibuchi H, Morimura K, Kinoshita A, Kang JS, Puatanachokchai R, Wei M, Funae Y, Fukushima S

CANCER SCIENCE 96 ( 11 ) 747 - 757 2005.11（ ISSN:1349-7006 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1111/j.1349-7006.2005.00110.x

PubMed
Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens Reviewed

Fukushima S, Kinoshita A, Puatanachokchai R, Kushida M, Wanibuchi H, Morimura K

CARCINOGENESIS 26 ( 11 ) 1835 - 1845 2005.11（ ISSN:0143-3334 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1093/carcin/bgi160

PubMed
Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens. Reviewed

Fukushima S, Morimura K, Wanibuchi H, Kinoshita A, Salim EI

Toxicology and applied pharmacology 207 ( 2 Suppl ) 225 - 9 2005.09（ ISSN:0041-008X ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.taap.2005.01.037

PubMed
Lack of large intestinal carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine at low doses in rats initiated with azoxymethane Reviewed

Doi K, Wanibuchi H, Salim EI, Morimura K, Kinoshita A, Kudoh S, Hirata K, Yoshikawa J, Fukushima S

INTERNATIONAL JOURNAL OF CANCER 115 ( 6 ) 870 - 878 2005.07（ ISSN:0020-7136 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1002/ijc.20960

PubMed
Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms

208 ( 3 ) 285 - 294 2005

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Publishing type：Research paper (scientific journal)
Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.

240 ( 1 ) 102 - 113 2005

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Publishing type：Research paper (scientific journal)
Understanding arsenic carcinogenicity by the use of animal models Reviewed

Wanibuchi H, Salim EI, Kinoshita A, Shen J, Wei M, Morimura K, Yoshida K, Kuroda K, Endo G, Fukushima S

TOXICOLOGY AND APPLIED PHARMACOLOGY 198 ( 3 ) 366 - 376 2004.08（ ISSN:0041-008X ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1016/j.taap.2003.10.032
Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster Reviewed

Morimura K, Romanenko A, Min W, Salim EI, Kinoshita A, Wanibuchi H, Vozianov A, Fukushima S

ONCOLOGY REPORTS 11 ( 4 ) 881 - 886 2004.04（ ISSN:1021-335X ）

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Publishing type：Research paper (scientific journal)
Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in P53(+/-) and P53(+/+) mice Reviewed

Wei M, Wanibuchi H, Morimura K, Salim EI, Moku M, Doi K, Mitsuhashi M, Masuda C, Shen J, Kinoshita A, Fukushima S

ANTICANCER RESEARCH 24 ( 2B ) 785 - 790 2004（ ISSN:0250-7005 ）

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Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats-association with oxidative DNA damage and enhanced cell proliferation Reviewed

Shen J, Wanibuchi H, Salim EI, Wei M, Kinoshita A, Yoshida K, Endo G, Fukushima S

CARCINOGENESIS 24 ( 11 ) 1827 - 1835 2003.11（ ISSN:0143-3334 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1093/carcin/bgg143
Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression Reviewed

Kinoshita A, Wanibuchi H, Morimura K, Wei M, Shen J, Imaoka S, Funae Y, Fukushima S

CARCINOGENESIS 24 ( 8 ) 1389 - 1399 2003.08（ ISSN:0143-3334 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1093/carcin/bgg079
High susceptibility of p53 knockout mice to esophageal and urinary bladder carcinogenesis induced by N,N-dibutylnitrosamine Reviewed

Nishikawa T, Salim EI, Morimura K, Kaneko M, Ogawa M, Kinoshita A, Osugi H, Kinoshita H, Fukushima S

CANCER LETTERS 194 ( 1 ) 45 - 54 2003.05（ ISSN:0304-3835 ）

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DOI： 10.1016/S0304-3835(03)00057-0
Urinary bladder lesions induced by persistent chronic low-dose ionizing radiation Reviewed

Romanenko A, Morimura K, Wanibuchi H, Wei M, Zaparin W, Vinnichenko W, Kinoshita A, Vozianov A, Fukushima S

CANCER SCIENCE 94 ( 4 ) 328 - 333 2003.04（ ISSN:1347-9032 ）

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Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S-transferase placental form positive foci: A possible reactive oxygen species mechanism Reviewed

Nishikawa T, Wanibuchi H, Ogawa M, Kinoshita A, Morimura K, Hiroi T, Funae Y, Kishida H, Nakae D, Fukushima S

INTERNATIONAL JOURNAL OF CANCER 100 ( 2 ) 136 - 139 2002.07（ ISSN:0020-7136 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1002/ijc.10471
Detailed low-dose study of 1,1-b is(p-chlorophenyl)-2,2,2-trichloroethane carcinogenesis suggests the possibility of a hormetic effect Reviewed

Sukata T, Uwagawa S, Ozaki K, Ogawa M, Nishikawa T, Iwai S, Kinoshita A, Wanibuchi H, Imaoka S, Funae Y, Okuno Y, Fukushima S

INTERNATIONAL JOURNAL OF CANCER 99 ( 1 ) 112 - 118 2002.05（ ISSN:0020-7136 ）

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Publishing type：Research paper (scientific journal)

DOI： 10.1002/ijc.10312
Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1 Reviewed

Kinoshita A, Wanibuchi H, Imaoka S, Ogawa M, Masuda C, Morimura K, Funae Y, Fukushima S

CARCINOGENESIS 23 ( 2 ) 341 - 349 2002.02（ ISSN:0143-3334 ）

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Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident Reviewed

Romanenko A, Morimura K, Wanibuchi H, Salim EI, Kinoshita A, Kaneko M, Vozianov A, Fukushima S

INTERNATIONAL JOURNAL OF CANCER 86 ( 6 ) 790 - 798 2000.06（ ISSN:0020-7136 ）

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Biochemical markers of fetal brain developmental disturbances Reviewed

Arutjunyan A.V., Pavlova N.G., Konstantinova N.N., Pavlenko A.V. (Kakehashi A.), Kashcheeva T.K., Kozina L.S., Kasheeva T.K.

International Journal of Developmental Neuroscience 14 108 - 108 1996

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Publishing type：Research paper (scientific journal) Kind of work：Joint Work
Biochemical markers of brain development disorders Reviewed

Arutjunyan A.V., Pavlova N.G., Konstantinova N.N., Pavlenko A.V. (Kakehashi A.), Kashcheeva T.K.,Lyzlova L.V., Kozina L.S., Rusina E.I., Mikhailov A.V., Shelaeva E.V.

Neurochemistry 13 ( 3 ) 187 - 193 1996

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Publishing type：Research paper (scientific journal) Kind of work：Joint Work

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Books and Other Publications

Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose–Response for Key Events in Rat Hepatocarcinogenesis. In: Thresholds of Genotoxic Carcinogens, From Mechanisms to Regulation,

（ Role： Joint author）

2016.12

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Total pages：210 Responsible for pages：1–17
Isoleucine, Leucine and Their Role in Experimental Models of Bladder Carcinogenesis. In: Branched Chain Amino Acids in Clinical Nutrition

Wei M., Xie X-L., Yamano S., Kakehashi A., Wanibuchi H. （ Role： Joint author）

2015
Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies

Fukushima S., Wei M., Kakehashi A., Wanibuchi H.（ Role： Joint author）

In: Cancer Risk Assessment: Chemical Carcinogenesis, Hazard Evaluation, and Risk Quantification, Chapter 8. Thresholds for Genotoxic Carcinogens: Evidence from Mechanism-Based Carcinogenicity Studies. Editors: Hsu C.-H. and Stedeford T. John Wiley & Sons, Inc., Hoboken, NJ, USA, 832 pages, pp. 207-222, 2010. 2010
Neurochemistry: Cellular, Molecular and Clinical Aspects. BB-isoform of creatine kinase in amniotic fluid as a marker of brain development disorders.

Arutjunyan A.V., Pavlova N.G., Konstantinova N.N., Pavlenko A.V.(Kakehashi A.), Kashcheeva T.K.,Lyzlova L.V., Kozina L.S., Rusina E.I., Mikhailov A.V., Shelaeva E.V.（ Role： Joint author）

1997

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Total pages：1226 Responsible for pages：457-460

MISC

1,4-ジオキサンはin vivo変異原性陽性であるその変異原性および発がん性の定量解析 Reviewed

魏民, 藤岡正喜, 梯アンナ, 奥野高裕, 増村健一, 能美健彦, 松本道治, 大森雅子, 鰐渕英機, 福島昭治

大阪市医学会雑誌 69 32 - 32 2020.12（ ISSN:0386-4103 ）

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NADPH oxidase阻害剤Apocyninは酸化ストレスの抑制を介しEHEN誘発ラット腎発がんを抑制する

藤岡正喜, 魏民, 山野荘太郎, 河内聡子, 土井賢一郎, 石井真美, 梯アンナ, 鰐渕英機

日本酸化ストレス学会学術集会プログラム・抄録集 69th 102‐103 2016.08

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J-GLOBAL
分子メカニズムからみた病変把握と免疫染色　病理組織のプロテオーム解析による病変マーカー開発 Reviewed

鰐渕英機, 梯アンナ, 藤岡正喜, 奥野高裕, 魏民

日本組織細胞化学会　組織細胞化学 2016 175 - 189 2016.07

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膀胱癌予防のためのリスク因子の同定と発癌機序の解明 Reviewed

立花大和, 魏民, 梯アンナ, 鰐渕英機

日本腎泌尿器疾患予防医学研究会　日本腎泌尿器疾患予防医学研究会誌 24 ( 1 ) 24 - 28 2016.03（ ISSN:1347-5010 ）

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Mcl‐1蛋白を標的とする低分子抗がん物質の毒性と有効性の評価

土井賢一郎, 鰐渕英機, 魏民, 梯アンナ, 石井真美, 山野荘太郎

日本毒性病理学会講演要旨集 32nd 72 (JA),182 (EN) 2016

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J-GLOBAL
遺伝毒性発癌物質に対する閾値　発癌リスク評価を中心に(Threshold for Genotoxic Carcinogens: The Central Concern in Carcinogenic Risk Assessment) Reviewed

Fukushima Shoji, Wei Min, Kakehashi Anna, Wanibuchi Hideki

日本環境変異原学会　Genes and Environment 34 ( 4 ) 153 - 156 2012.11（ ISSN:1880-7046 ）

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非遺伝毒性肝発がん物質のラット肝臓における遺伝子発現解析

神吉将之, 魏民, 梯アンナ, 山野荘太朗, 鰐渕英機

日本毒性病理学会講演要旨集 28回 77 - 77 2012.02

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膀胱癌UPDATE(No.1) 目で診る膀胱癌　癌組織像を診る　チェルノブイリ膀胱炎と膀胱癌 Reviewed

鰐渕英機, 梯アンナ, 魏民, 福島昭治

医学図書出版(株)　泌尿器外科 24 ( 11 ) 1748 - 1753 2011.11（ ISSN:0914-6180 ）

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MicroRNA-125bはラット膀胱発がんの早期マーカーとして有用である(MircroRNA-125b is a potential early marker of rat urinary bladder carcinogenesis)

魏民, 梯アンナ, 山野荘太郎, 石井真美, 北野光昭, 鰐渕英機

日本癌学会総会記事 68回 146 - 147 2009.08（ ISSN:0546-0476 ）

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QSTAR Elite LC-MS/MSを用いたマウス肺腫瘍におけるプロテオーム解析(The proteome analysis of mice lung tumors by QSTAR Elite LC-MS/MS)

山野荘太郎, 梯アンナ, 魏民, 多胡善幸, 陳慶義, 鰐渕英機

日本癌学会総会記事 68回 121 - 121 2009.08（ ISSN:0546-0476 ）

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ラット多臓器発がんにおける糖尿病の影響(Modifying effects of diabetes mellitus in a rat multi-organ carcinogenesis model)

石井真美, 魏民, 梯アンナ, 仲谷慎也, 森聖, 鰐渕英機

日本癌学会総会記事 68回 118 - 118 2009.08（ ISSN:0546-0476 ）

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ラット膀胱発がん早期におけるイソロイシンおよびロイシンの修飾作用の検討(Effects of L-isoleucine and L-leucine at early stage of rat bladder carcinogenesis)

謝暁利, 山野荘太郎, 陳慶義, 梯アンナ, 鰐渕英機

日本癌学会総会記事 68回 110 - 110 2009.08（ ISSN:0546-0476 ）

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膀胱発がん物質の早期検出マーカーの検討

魏民, 梯アンナ, 福島昭治, 鰐渕英機

日本病理学会会誌 98 ( 1 ) 226 - 226 2009.03（ ISSN:0300-9181 ）

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ZDFラットを用いた糖尿病の発がんに及ぼす影響

石井真美, 魏民, 梯アンナ, 多胡善幸, 鰐渕英機

日本病理学会会誌 98 ( 1 ) 320 - 320 2009.03（ ISSN:0300-9181 ）

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マウス肝発がんにおけるプロテオーム及びバイオマーカーの検討

梯アンナ, 石井真美, 魏民, 鰐渕英機

日本病理学会会誌 98 ( 1 ) 357 - 357 2009.03（ ISSN:0300-9181 ）

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食品などに含まれる発がん物質に閾値が存在するのか

福島昭治, 梯アンナ, 魏民, 鰐渕英機

食品衛生学雑誌 49 ( 5 ) J - 314 2008.10（ ISSN:0015-6426 ）

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大豆イソフラボンのラット乳腺および子宮発がんに対する修飾作用(Modifying effects of soybean isoflavone on mammary gland and uterus carcinogenesis in Donryu rats)

多胡善幸, 梯アンナ, 北野光昭, 山野荘太郎, 大西真里子, 鰐渕英機

日本癌学会総会記事 67回 181 - 181 2008.09（ ISSN:0546-0476 ）

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Oncomodulinはラット膀胱発がんの早期マーカーとして有用である(Oncomodulin is a potential early marker of urinary bladder carcinogenesis in rats)

魏民, 森村圭一朗, 梯アンナ, 土井賢一郎, 福島昭治, 鰐渕英機

日本癌学会総会記事 67回 118 - 118 2008.09（ ISSN:0546-0476 ）

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マウスにおける肝前がん病変マーカーの検索(Analysis of novel protein biomarkers in mice hepatocarcinogenesis)

植松真美, 梯アンナ, 今中麻幸代, 魏民, 森聖, 鰐渕英機

日本癌学会総会記事 67回 122 - 122 2008.09（ ISSN:0546-0476 ）

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ラット肝発がんにおけるGST-P陽性細胞巣のプロテオーム及びバイオマーカーの検討(Proteomics of GST-P positive foci in rat hepatocarcinogenesis: Analysis of potential biomarkers)

梯アンナ, 今中麻幸代, 魏民, 大西真里子, 福島昭治, 鰐渕英機

日本癌学会総会記事 67回 122 - 122 2008.09（ ISSN:0546-0476 ）

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Ogg1遺伝子欠損マウスにおける多臓器発がんの検討

植松真美, 梯アンナ, 魏民, 北野光昭, 福島昭治, 鰐渕英機

日本病理学会会誌 97 ( 1 ) 368 - 368 2008.03（ ISSN:0300-9181 ）

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ジフェニルアルシン酸のラット肝発がんプロモーション作用

魏民, 梯アンナ, 土井賢一郎, 森村圭一朗, 福島昭治, 鰐渕英機

日本病理学会会誌 97 ( 1 ) 267 - 267 2008.03（ ISSN:0300-9181 ）

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チェルノブイリ原発事故後の長期低用量放射線暴露による膀胱がんの発生

梯アンナ, 森村圭一朗, 猪上麻幸代, 魏民, 福島昭治, 鰐渕英機

日本病理学会会誌 97 ( 1 ) 343 - 343 2008.03（ ISSN:0300-9181 ）

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大豆イソフラボンのラット乳腺発がんおよび子宮に対する修飾作用

多胡善幸, 梯アンナ, 今中麻幸代, 魏民, 森村圭一朗, 林修次, 鰐渕英機

日本毒性病理学会講演要旨集 24回 94 - 94 2008.02

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【尿路系腫瘍をめぐる諸問題】尿路上皮癌の組織分類新WHO分類との対比

鰐渕英機, 魏民, 梯アンナ, 福島昭治

病理と臨床 26 ( 2 ) 124 - 129 2008.02（ ISSN:0287-3745 ）

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OGG1遺伝子欠損マウスにおける多臓器発がんの検討

植松真美, 梯アンナ, 魏民, 森村圭一朗, 北野光昭, 福島昭治, 鰐渕英機

日本毒性病理学会講演要旨集 24回 84 - 84 2008.02

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臭素酸カリウムのラット腎臓における変異原性と発がん性の閾値の存在

魏民, 森村圭一朗, 梯アンナ, 串田昌彦, 當真香織, 鰐渕英機, 福島昭治

日本毒性病理学会講演要旨集 24回 88 - 88 2008.02

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マウス肝発がんにおける前がん病変マーカーの検索および機序解析

加藤あゆみ, 梯アンナ, 魏民, 多胡善幸, 山野荘太郎, 村井隆, 鰐渕英機

日本毒性病理学会講演要旨集 24回 79 - 79 2008.02

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ラット膀胱発癌におけるロイシン、イソロイシンの修飾作用の検討

山野荘太郎, 柚木孝之, 梯アンナ, 森聖, 福島昭治, 鰐渕英機

日本毒性病理学会講演要旨集 24回 92 - 92 2008.02

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ラット肝発がんにおけるGST-P陽性細胞巣のプロテオームおよびバイオマーカー解析

梯アンナ, 魏民, 森村圭一朗, 串田昌彦, 福島昭治, 鰐渕英機

日本毒性病理学会講演要旨集 24回 79 - 79 2008.02

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【毒性病理学の最近の話題】慢性ヒ素汚染がんと烏脚病

鰐渕英機, 魏民, 梯アンナ, 福島昭治

病理と臨床 25 ( 8 ) 780 - 785 2007.08（ ISSN:0287-3745 ）

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マウス肝発がんにおける前がん病変マーカーの検索(Cytokeratin 8/18 as a novel preneoplastic lesion marker regarding hepatocarcinogenesis in mice)

加藤あゆみ, 梯アンナ, 魏民, 當眞香織, 植松真美, 鰐渕英機

日本癌学会総会記事 66回 111 - 111 2007.08（ ISSN:0546-0476 ）

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ラット肝中期発癌性試験法を用いたマスティックの発癌性評価(Carcinogenic Effect of Mastic on Rat Liver Median-term Bioassay)

土井賢一郎, 魏民, 梯アンナ, 今中麻幸代, 當眞香織, 鰐渕英機

日本癌学会総会記事 66回 47 - 47 2007.08（ ISSN:0546-0476 ）

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ラットを用いたプロポリスの発がん性試験(Lack of carcinogenicitv of Propolis in rats)

鰐渕英機, 梯アンナ, 今中麻幸代, 當眞香織, 魏民, 森村圭一朗, 福島昭治

日本癌学会総会記事 66回 355 - 355 2007.08（ ISSN:0546-0476 ）

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Presentations

ヒト化肝臓マウスを用いた4,4’-methylenebis(2-chloroaniline)のヒト化肝細胞での代謝と膀胱発がん性の検証 Domestic conference

鈴木周五、魏民、藤岡正喜、Arpamas Vachiraarunwong、梯アンナ、鰐渕英機

2024年度文部科学省学術変革領域研究学術研究支援基盤形成先端モデル動物支援プラットフォーム成果発表会 2025.02

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Presentation type：Oral presentation (general)

Venue：滋賀
ヒト浸潤性膵管癌における新規マーカーとしての3 の解析及び発がん機序解明 Domestic conference

梯アンナ、鈴木周五、西土井悠作、邱桂鈺、Vachiraarunwon Arpamas、藤岡正喜、魏民、鰐渕英機

第41回日本毒性病理学会総会及び学術集会 2025.01

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Presentation type：Poster presentation

Venue：静岡
Oncomodulin is a novel early marker of urinary bladder carcinogenesis in rats Domestic conference

Runjie Guo, Min Gi, Arpamas Vachiraarunwong, Shugo Suzuki, Masaki Fujioka, Guiyu Qiu, Anna Kakehashi, Hideki Wanibuchi

2025.01

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Presentation type：Poster presentation
Hepatotoxicity of per-and polyfluoroalkyl substanes on immortalized human hepatocytes Domestic conference

Arpamas Vachiraarunwong, Masaki Fujhioka, Guiyu Qiu, Runjie Guo, Shugo Suzuki, Ikue Noura, Anna Kakehashi, Hideki Wanibuchi, Min Gi

第41回日本毒性病理学会総会及び学術集会 2025.01

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Presentation type：Poster presentation

Venue：静岡
A novel support vector machine-based one-day, single-dose prediction model of genotoxic hepatocarcinogenicity in rats Domestic conference

Guiyu Qiu, Min Gi, Shugo Suzuki, Masaki Fujioka, Anna Kakehashi, Arpamas Vachiraarunwong, Ikue Noura, Runjie Guo, Hideki Wanibuchi

2025.01

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有機ヒ素化合物ジフェニルアルシン酸の発達期ばく露によるF1ラット海馬神経新生に及ぼす影響 Domestic conference

邱桂鈺、魏民、藤岡正喜、鈴木周五、ワチラルンウオン　アルパマス、野浦郁恵、郭潤傑、梯アンナ、鰐渕英機

第29回ヒ素シンポジウム 2024.12

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Presentation type：Oral presentation (general)

Venue：徳島
遺伝毒性肝発がん物質の超短期検出モデルの確立(Development of Rapid Models for Predicting Genotoxic Hepatocarcinogenicity in Rats) Domestic conference

邱桂ギョク, 魏民, 鈴木周五, 藤岡正喜, Vachiraarunwong Arpamas, 郭潤傑, 梯アンナ, 鰐渕英機, 鰐渕英機

第83回日本癌学会総会　日本癌学会総会記事 2024.09 (一社)日本癌学会

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Presentation type：Poster presentation

Venue：福岡国際会議場
ヒト浸潤性膵管癌の新規バイオマーカーとしてPRDX3の検討(PRDX3 as a novel biomarker of human invasive pancreatic ductal carcinoma) Domestic conference

梯アンナ, 西土井悠作, 邱桂ギョク, 鈴木周五, 野浦郁恵, アルパマス・ワチラアルンウオン , 藤岡正喜, 魏民, 鰐渕英機

第83回日本癌学会総会　日本癌学会総会記事 2024.09 (一社)日本癌学会

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Presentation type：Poster presentation

Venue：福岡国際会議場
ヒト化肝マウスにおけるジメチルアルシン酸の肝発癌性の評価(Evaluation of the Hepatocarcinogenic Potential of Dimethylarsinic Acid in Humanized-Liver Mice) Domestic conference

Vachiraarunwong Arpamas, 藤岡正喜, 鈴木周五, 郭潤傑, Qiu Giuyu, Praseatsook Kwanchanok, 野浦郁恵, 梯アンナ, 鰐渕英機, 魏民, Gi Min

第83回日本癌学会総会　日本癌学会総会記事 2024.09 (一社)日本癌学会

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Presentation type：Poster presentation

Venue：福岡国際会議場
Oncomodulinのラット膀胱発がんにおける役割(Role of Oncomodulin in N-butyl-N-(4-hydroxybutyl) nitrosamine-induced Rat Bladder Carcinogenesis) Domestic conference

郭潤傑, 魏民, Vachiraarunwong Arpamas, 鈴木周五, 藤岡正喜, 邱桂ギョク, Praseatsook Kwanchanok, 梯アンナ, 鰐渕英機

第83回日本癌学会総会　日本癌学会総会記事 2024.09 (一社)日本癌学会

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Presentation type：Poster presentation

Venue：福岡国際会議場
肺大細胞神経内分泌癌の新規バイオマーカー候補の検討(Examination of new biomarker candidates for large cell neuroendocrine carcinoma of the lung) Domestic conference

野浦郁恵, 鈴木周吾, 梯アンナ, 井上健, 鰐渕英機, 鈴木周五

第83回日本癌学会総会　日本癌学会総会記事 2024.09 (一社)日本癌学会

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Presentation type：Poster presentation

Venue：福岡国際会議場
o-Toluidine誘発ラット膀胱増殖性病変に対するNADPH酸化酵素阻害剤apocyninの抑制効果(Effects of apocynin, NADPH oxidase inhibitor, on o-toluidine-induced urinary bladder proliferation) Domestic conference

鈴木周五, 魏民, 藤岡正喜, Vachiraarunwong Arpamas, 梯アンナ, 鰐渕英機

第83回日本癌学会総会　日本癌学会総会記事 2024.09 (一社)日本癌学会

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Venue：福岡国際会議場
ヒト化肝臓マウスモデルを用いたヒ素の代謝および毒性の評価 International coauthorship Domestic conference

Arpamas Vachiraarunwong, Min Gi, Masaki Fujioka, Shugo Suzuki, Runjie Guo, Guiyu Qiu, Ikue Noura, Anna Kakehashi, Hideki Wanibuchi

第37回発癌病理研究会講演12 2024.08 鳥取

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ジメチルアルシン酸経胎盤ばく露肝発がんにおける脂質代謝異常の関与 Domestic conference

鈴木周五、藤岡正喜、魏民、アルパマス　ワチラアルンウオン、梯アンナ、鰐渕英機

第20回日本病理学会カンファレンス 2024.06

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Presentation type：Oral presentation (general)

Venue：山形
ジメチルアルシン酸誘発ラット膀胱発がんにおけるDNAメチル化異常 Domestic conference

魏民、山本与毅、鈴木周五、藤岡正喜、ワチラアルンウオン　アルパマス、郭潤傑、Qiu Guiyu、梯アンナ、鰐渕英機

第113回日本病理学会総会 2024.03

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Presentation type：Poster presentation
Evaluation of Developmental Neurotoxicity of Diphenylarsinic Acid in SD Rats Domestic conference

2024.03

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Presentation type：Poster presentation
不死化ヒト膀胱上皮細胞を用いた三次元膀胱培養モデルの確立及びそれを用いたヒ素毒性評価 Domestic conference

郭潤傑、魏民、ワチラアルンウオン　アルパマス、藤岡正喜、鈴木周五、Guiyu Qiu、山本与毅、梯アンナ、鰐渕英機

第113回日本病理学会総会 2024.03

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NADPH酸化酵素阻害剤apocyninによるo-toluidine誘発ラット膀胱増殖性病変への抑制効果 International coauthorship Domestic conference

鈴木周五、魏民、藤岡正喜、Guiyu Qiu、Arpamas Vachiraarunwon、梯アンナ、鰐渕英機

第113回日本病理学会総会 2024.03

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ヒト浸潤性膵管癌の新規バイオマーカー候補の解明 Domestic conference

梯アンナ、西土井悠作、Qiu Guiyu、鈴木周五、藤岡正喜、魏民、鰐渕英機

第113回日本病理学会総会 2024.03

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肺大細胞神経内分泌癌の新規バイオマーカー候補の検討 Domestic conference

野浦郁恵、鈴木周五、梯アンナ、魏民、藤岡正喜、ワチラアルンウオン　アルパマス、井上健、鰐渕英機

第113回日本病理学会総会 2024.03

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NAFLD/NASH肝発がんマーカーや分子機序への最近の洞察 Domestic conference

梯アンナ

第11回ライフサイエンス談話会 2024.03

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Toxicological Assessment of Dimethylarsinic Acid Using Humanized Liver Mice Model International coauthorship Domestic conference

Arpamas Vachiraarunwon, Gi M., Fujioka M., Suzuki S., Qiu G., Guo R., Kakehashi A.Wanibuchi H.

第113回日本病理学会総会 2024.02

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ジフェニルアルシン酸の経胎盤曝露によるF1マウス肝発がん機序にはDNA メチル化異常が関与する Domestic conference

藤岡正喜、魏民、鈴木周五、大石裕司、ワチラアルンウオン　アルパマス、邱桂ギョク、芝野佳奈、梯アンナ、鰐渕英機

第113回日本病理学会総会 2024.02

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Diphenylarsinic acid induced transplacental liver carcinogenesis via epigenetic alterations in F1 mice Domestic conference

2024.02

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Development of an in vitro dosing assay for trans-tracheal intrapulmonary spraying administration of chemicals in rats International coauthorship Domestic conference

Min Gi, Masaki Fujioka, Kana Shibano, Guiyu Qiu, Arpamas Vachiraarunwong, Runjie Guo1, Anna Kakehashi, Shugo Suzuki, Hideki Wanibuchi

2024.01

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Evaluating hepatic metabolism and carcinogenicity of dimethylarsinic acid using humanized liver mice model International coauthorship Domestic conference

Vachiraarunwong A., Gi M., Fujioka M., Suzuki S., Qiu G., Guo R., Kakehashi A., Wanibuchi H.

2024.01

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Development of a novel 3D urinary bladder mucosa model and evaluation of assessing arsenical toxicity International coauthorship Domestic conference

Runjie Guo, Min Gi, Tohru Kiyono, Arpamas Vachiraarunwong, Masaki Fujioka, Shugo Suzuki, Guiyu Qiu, Tomoki Yamamoto, Anna Kakehashi, Hideki Wanibuchi

第40回日本毒性病理学会総会及び学術集会 2024.01

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Venue：品川区立総合区民会館きゅりあん
Diphenylarsinic acid induced transplacental liver carcinogenesis via epigenetic changes in F1 mice Domestic conference

Masaki Fujioka, Min Gi, Shugo Suzuki, Yuji Oishi, Arpamas Vachiraarunwong,Guiyu Qiu, Kana Shibano, Anna Kakehashi, Hideki Wanibuchi

The 40th Meeting of Toxicologic Pathology of Japan (JSTP) 2024.01

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Effect of diphenylarsinic acid on hippocampal neurogenesis in SD rats International coauthorship Domestic conference

The 40th Meeting of Toxicologic Pathology of Japan (JSTP) 2024.01

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ジメチルアルシン酸の経胎盤ばく露による肝発がんに脂質代謝異常が関与する International coauthorship Domestic conference

鈴木周五、魏民、藤岡正喜、Arpamas Vachiraarunwong、梯アンナ、鰐渕英機

第40回日本毒性病理学会総会及び学術集会 2024.01

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ジメチルアルシン酸の経胎盤ばく露による肝発がんに脂質代謝異常が関与する Domestic conference

鈴木周五、魏民、藤岡正喜、Arpamas Vachiraarunwong、梯アンナ、鰐渕英機

第40回日本毒性病理学会総会及び学術集会 2024.01
ヒト浸潤性膵管癌の新規バイオマーカー候補の検討及び発がん機序解明 Domestic conference

梯アンナ, 西土井悠作, Qiu Guiyu, 鈴木周五, 藤岡正喜, Vachiraarunwong Arpamas, 魏民, 鰐渕英機

第40回日本毒性病理学会総会及び学術集会　日本毒性病理学会講演要旨集 2024.01 (一社)日本毒性病理学会

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Venue：品川区立総合区民会館きゅりあん
Examination of novel biomarker candidates of human invasive pancreatic ductal carcinoma International coauthorship Domestic conference

2023.09

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Comparison of carcinogenicity of arsenicals on immortalized human bladder epithelial cells International coauthorship Domestic conference

2023.09

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Glutelin hydrolysate of purple rice bran exhibited cancer chemopreventive activity against liver and colon carcinogenesis Domestic conference

Arpamas Vachiraarunwong, Aroonrat Pharapirom, Rawiwan Wongpoomchai, Min Gi, Shugo Suzuki, Anna Kakehashi, Masaki Fujioka, Hideki Wanibuchi

2023.09

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有機ヒ素化合物ジフェニルアルシン酸経胎盤ばく露マウスにおける肝発がん過程にはDNAメチル化異常が関与する(Diphenylarsinic acid induced hepatocarcinogenesis via altered DNA methylation in a transplacental mouse model) Domestic conference

藤岡正喜, 魏民, 鈴木周五, 大石裕司, アルパマス・ワチラアルンウオン , 邱桂ギョク, 芝野佳奈, 梯アンナ, 鰐渕英機

第82回日本癌学会総会　日本癌学会総会記事 2023.09 (一社)日本癌学会

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Venue：パシフィコ　横浜
多層カーボンナノチューブとフラーレンウィスカーの肺発がん性の解析(The lung carcinogenicity of multi-walled carbon nanotubes and fullerene whiskers) Domestic conference

内木綾, 加藤寛之, 梯アンナ, 津田洋幸, 高橋智

第82回日本癌学会総会　日本癌学会総会記事 2023.09 (一社)日本癌学会

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Venue：パシフィコ　横浜
単層カーボンナノチューブの肺および中皮発がん性の解析(Evaluation of lung and mesothelial carcinogenicity of single-walled carbon nanotube in male Fisher 344 rats) Domestic conference

シーマ・アシラフウル・ナハル , 内木綾, 梯アンナ, 加藤寛之, 津田洋幸, 高橋智

第82回日本癌学会総会　日本癌学会総会記事 2023.09 (一社)日本癌学会

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Venue：パシフィコ　横浜
ヒト浸潤性膵管癌の新規バイオマーカー候補の検討(Examination of novel biomarker candidates of human invasive pancreatic ductal carcinoma) International coauthorship Domestic conference

梯アンナ, 西土井悠作, Qiu Guiyu, 鈴木周五, 藤岡正喜, ワチラアルンウオン・アルパマス , 魏民, 鰐渕英機

第82回日本癌学会総会　日本癌学会総会記事 2023.09 (一社)日本癌学会

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Venue：パシフィコ　横浜
ジメチルアルシン酸の経胎盤ばく露による肝発がんに脂質代謝異常が関与する(Dimethylarsinic acid(DMA) enhanced hepatocarcinogenesis via altered lipid metabolism in a transplacental mouse model) Domestic conference

鈴木周五, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

第82回日本癌学会総会　日本癌学会総会記事 2023.09 (一社)日本癌学会

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Venue：パシフィコ横浜
不死化ヒト膀胱上皮細胞におけるヒ素の発がん性の比較(Comparison of carcinogenicity of arsenicals on immortalized human bladder epithelial cells) Domestic conference

ワチラアルンウオン・アルパマス , 魏民, 鈴木周五, 芝野佳奈, 郭潤傑, Pharapirom Aroonrat, 梯アンナ, 藤岡正喜, 鰐渕英機, Wanibuchi Hideki

第82回日本癌学会総会　日本癌学会総会記事 2023.09 (一社)日本癌学会

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Venue：パシフィコ横浜
結膜MALTリンパ腫と眼窩MALTリンパ腫の遺伝子発現クラスターの比較 Domestic conference

田上瑞記, 笠島裕明, 梯アンナ, 吉川敦子, 坂井淳, 三澤宣彦, 鰐渕英機, 安積淳, 八代正和, 本田茂

眼科臨床紀要　巻： 16 号： 5 ページ： 391 2023.05 眼科臨床紀要会), 巻： 16 号： 5 ページ： 391, JST資料番号： Z0319C

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職業性ばく露を認めたo-toluidineの尿中代謝物による膀胱尿路上皮への影響 Domestic conference

鈴木周五, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

第112回日本病理学会総会　日本病理学会会誌 2023.03 (一社)日本病理学会

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ジメチルアルシン酸誘発ラット膀胱がんにおけるDNAメチル化異常 International coauthorship Domestic conference

山本与毅、魏民、鈴木周五、藤岡正喜、Vachirarunwon Arpamas、Guiyu Qiu、芝野佳奈、清水一希、梯アンナ、鰐渕英機

第39回日本毒性病理学会総会および学術集会、若手ワークショップ W-5、東京（ハイブリッド開催） 2023.01

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ヒト浸潤性膵管癌の新規バイオマーカー候補の解析 Domestic conference

梯アンナ、西土井悠作、Guiyu Qiu、鈴木周五、藤岡正喜、魏民、鰐渕英機．

第39回日本毒性病理学会総会および学術集会P-30, 東京（ハイブリッド開催） 2023.01

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職業性ばく露を認めたo-toluidineの尿中代謝物による膀胱尿路上皮への影響 Domestic conference

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第39回日本毒性病理学会総会および学術集会、P-50, 東京（ハイブリッド開催） 2023.01

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マウス経胎盤曝露モデルにおけるジフェニルアルシン酸（DPAA）のエピジェネティック修飾異常を介した肝発がんの亢進 International coauthorship Domestic conference

藤岡正喜、魏民、鈴木周五、芝野佳奈、Guiyu Qiu、Arpamas Vachirarunwon、Pharapirom Aroonrat、大石裕司、梯アンナ、鰐渕英機

第39回日本毒性病理学会総会および学術集会、P-34, 東京（ハイブリッド開催） 2023.01

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ヒト浸潤性膵管癌におけるPRDX3の機能解明 International coauthorship Domestic conference

Guiyu Qiu、梯アンナ、鈴木周五、藤岡正喜、魏民、Arpamas Vachirarunwon、Pharapirom Aroonrat、芝野佳奈、鰐渕英機

第39回日本毒性病理学会総会および学術集会、P-31, 東京（ハイブリッド開催） 2023.01

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多層カーボンナノチューブおよびフラーレンウィスカーの肺発がん性の比較 Domestic conference

内木綾、加藤寛之、梯アンナ、津田洋幸、高橋智

第39回日本毒性病理学会総会および学術集会、P-16, 東京（ハイブリッド開催） 2023.01

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The lung carcinogenicity of single-walled carbon nanotube in male Fischer 344 rats International coauthorship Domestic conference

Asraful Nahar Sheema, Aya Naiki-Ito, Hiroyuki Kato , Anna Kakehashi, Hiroyuki Tsuda,　Satoru Takahashi

39th Conference of JSTP, P15 2023.01
Toxicities of various arsenicals on immortalized normal human bladder epithelial cells International coauthorship Domestic conference

Arpamas Vachiraarunwong, Min Gi, Tohru Kiyono, Shugo Suzuki, Kana Shibano, Guiyu Qiu, Pharapirom Aroonrat, Anna Kakehashi, Masaki Fujioka, Hideki Wanibuchi

2023.01

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ジメチルアルシン酸による膀胱発がん機序の解明 Domestic conference

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第27回ヒ素シンポジウム、今治市 2022.12

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ヒ素誘発膀胱発がん過程におけるDNAメチル化異常の関与 Domestic conference

魏民、藤岡正喜、鈴木周五、山本与毅、Vachirarunwon Arpamas、梯アンナ、鰐渕英機

第27回ヒ素シンポジウム、今治市 2022.12

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マウス経胎盤ばく露による有機ヒ素化合物の発がん性およびその機序 Domestic conference

藤岡正喜、魏民、鈴木周五、大石裕司、梯アンナ、邱桂鈺、芝野佳奈、鰐渕英機

第35回発癌病理研究会、新潟県 2022.11

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Diphenylarsinic acid (DPAA) enhanced hepatocarcinogenesis via　epigenetic alteration in a transplacental mouse model International conference

Masaki Fujioka, Min Gi, Shugo Suzuki, Yuji Oishi, Guiyu Qiu, Anna　Kakehashi, Hideki Wanibuchi

2022.09

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DNA Methylation in Dimethylarsinic Acid-induced Rat Bladder Carcinogenesis International conference

Min Gi, Shugo Suzuki, Satoshi Yamashita, Masaki Fujioka, Anna Kakehashi, Tomoki Yamamoto, Guiyu Qiu

2022.09

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Occupational bladder cancer with exposure of aromatic amines International conference

Shugo Suzuki, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi

2022.09

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Presentation type：Symposium, workshop panel (public)
1,4-ジオキサンの肝発がん機序の解明と定量的発がんリスク評価 Domestic conference

魏民、鈴木周五、藤岡正喜、梯アンナ、鰐渕英機

第49回日本毒性学会学術年会、P-190、札幌 2022.06

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職業性ばく露を認めたo-toluidoneの尿中代謝物と膀胱尿路上皮への影響 Domestic conference

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第49回日本毒性学会学術年会、Workshop W-5, 札幌　 2022.06

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職業性ばく露を認めたο-toluidineの尿中代謝物と膀胱尿路上皮への影響 Domestic conference

鈴木周五, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

第49回日本毒性学会学術年会 2022.06 (一社)日本毒性学会

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職業性膀胱がん関連芳香族アミン類の尿中代謝物と膀胱尿路上皮への影響 Domestic conference

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第111回日本病理学会総会、P-435, 神戸 2022.04

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Canopy homolog 2 as a novel molecular target in hepatocarcinogenesis Domestic conference

2022.04

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Presentation type：Poster presentation
炭酸脱水素酵素阻害剤AcetazolamideのWnt/βカテニンシグナル経路抑制を介した膀胱癌浸潤抑制効果 International conference

松江泰佑、魏民、塩田正之、鈴木周五、藤岡正喜、梯アンナ、内田潤次、鰐渕英機

第38回日本毒性病理学会総会及び学術集会・第1回アジア毒性病理学連盟学術集会、若手ワークショップ W-1, 神戸（ハイブリッド開催） 2022.01

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Recent insights into mechanisms driving NAFLD/NASH-associated hepatocarcinogenesis International conference

Joint Meeting of JSTP and AUTP 2022, The 38th Meeting of the Japanese Society of Toxicologic Pathology, The 1st Meeting of Asian Union of Toxicologic Pathology

2022.01

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肺組織におけるタバコの短期曝露による初期反応バイオマーカーの探索 International conference

西土井悠作、鈴木周五、魏民、梯アンナ、松江泰佑、鰐渕英機

第38回日本毒性病理学会総会及び学術集会・第1回アジア毒性病理学連盟学術集会、P-45, 神戸（ハイブリッド開催） 2022.01

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職業性膀胱がん関連芳香族アミンの膀胱尿路上皮への影響及び尿中代謝物との関係 International conference

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第38回日本毒性病理学会総会及び学術集会・第1回アジア毒性病理学連盟学術集会、P-85, 神戸（ハイブリッド開催） 2022.01

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1,4- ジオキサンのin vivo変異原性及び発がん性の定量解析 International conference

魏民、鈴木周五、藤岡正喜、梯アンナ、鰐渕英機

第38回日本毒性病理学会総会及び学術集会・第1回アジア毒性病理学連盟学術集会、P-62, 神戸（ハイブリッド開催） 2022.01

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有機ヒ素化合物DPAAのマウス経胎盤曝露による次世代に対する発がん影響及びその機序の検討 International conference

藤岡正喜、魏民、鈴木周五、梯アンナ、大石裕司、山口貴嗣、鰐渕英機

第38回日本毒性病理学会総会及び学術集会・第1回アジア毒性病理学連盟学術集会、P-61, 神戸（ハイブリッド開催） 2022.01

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Toxicologic pathology and beyond～先端技術で拓く新毒性病理学～　NAFLD/NASH肝発がんの促進機序への最近の洞察 Domestic conference

梯アンナ, 鰐渕英機

第38回日本毒性病理学会総会及び学術集会・第1回アジア毒性病理学連盟学術集会　日本毒性病理学会講演要旨集 2022.01 (一社)日本毒性病理学会

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肝発がんにおける特異的候補分子としてCNPY2の役割

梯アンナ、鈴木周五、藤岡正喜、魏民、鰐渕英機

第80回日本癌学会学術総会、横浜（ハイブリッド開催）J1-5 2021.10
ジフェニルアルシン酸のマウス経胎盤ばく露による発がん性の検討

藤岡正喜、魏民、鈴木周五、大石裕司、山口貴嗣、松江泰佑、梯アンナ、鰐渕英機

第80回日本癌学会学術総会、P2-1-3,（横浜（ハイブリッド開催） 2021.09
職業性ばく露香族アミンによる膀胱尿路上皮への影響と尿中代謝の関係

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第80回日本癌学会学術総会、P1-1-5 、横浜（ハイブリッド開催） 2021.09
遺伝子セットを用いた遺伝毒性肝発がん超短期検出法

魏民、鈴木周五、藤岡正喜、梯アンナ、鰐渕英機

第80回日本癌学会学術総会、P1-1-1,（横浜（ハイブリッド開催） 2021.09
有機ヒ素化合物DPAAのマウス経胎盤曝露による次世代に対する発がん影響及びその機序の検討

藤岡正喜、魏民、鈴木周五、大石裕司、梯アンナ、鰐渕英機

2021年度新学術領域研究「学術研究支援基盤形成【先端モデル動物支援プラットフォーム(AdAMS)】」若手支援技術講習会、オンライン開催 2021.09
職業性ばく露芳香族アミン類による膀胱尿路上皮への影響と尿中代謝物の関係 Domestic conference

鈴木周五, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

第80回日本癌学会学術総会　日本癌学会総会記事 2021.09 (一社)日本癌学会

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職業性ばく露を認めた芳香族アミン類による尿中代謝物と膀胱尿路上皮影響の関係

鈴木周五、魏民、藤岡正喜、梯アンナ、鰐渕英機

第48回日本毒性学会学術年会、神戸（ハイブリッド開催） 2021.07
アグリコン型イソフラボンによるホルモン活性がDonryuラットにおける乳がんおよび子宮内膜がんの発生を促進する

藤岡正喜、梯アンナ、魏民、鰐渕英機．

日本食品化学学会第27回総会・学術大会、B-16, 東京（ハイブリッド開催） 2021.06
Pueraria mirificaのエストロゲン作用によるDonryuラットにおける乳がんの発生

梯アンナ、藤岡正喜、魏民、鰐渕英機

日本食品化学学会第27回総会・学術大会、B-18, 東京（ハイブリッド開催） 2021.06
ラット肝腫瘍評価におけるナノ粒子造影剤(ExiTron nano 12000)による造影CTの有用性 Domestic conference

野田健仁, 影山健, 山本晃, 梯アンナ, 尾崎正典, 米澤宏記, 村井一超, 小川聡幸, 寒川悦次, 城後篤志, 三木幸雄

日本インターベンショナルラジオロジー学会雑誌 2021.04 (一社)日本インターベンショナルラジオロジー学会

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結膜扁平上皮癌におけるthrombospondin-1の発現と予後予測及びKi67 indexの相関の探求 Domestic conference

田上瑞記, 梯アンナ, 吉川敦子, 三澤宜彦, 坂井淳, 鰐淵英機, 安積淳, 本田茂

日本眼科学会雑誌 2021.03 (公財)日本眼科学会

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マウス肝発がんにおける新規マーカーとしてcanopy homolog 2の解明 Domestic conference

梯アンナ、鈴木周五、藤岡正喜、魏民、鰐渕英機

第37回日本毒性病理学会総会及び学術集会 2021.01

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化審法に有用な新規化学物質の肝発がん性評価スキームの創出 Domestic conference

化審法に有用な新規化学物質の肝発がん性評価スキームの創出

第37回日本毒性病理学会総会及び学術集会 2021.01

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毒性病理リスク評価の進歩　化審法に有用な新規化学物質の肝発がん性評価スキームの創出 Domestic conference

魏民, 鈴木周五, 藤岡正喜, 梯アンナ, 鰐渕英機

第37回日本毒性病理学会総会及び学術集会日本毒性病理学会講演要旨集 2021.01 (一社)日本毒性病理学会

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Venue：第37回日本毒性病理学会総会及び学術集会
NASH肝発がんにおける特異的候補分子および新規マーカーとしてCACHD1の役割 Domestic conference

7. 梯アンナ、鈴木周五、魏民、鰐渕英機

第79回日本癌学会学術総会 2020.10

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有機ヒ素化合物の経胎盤ばく露によるマウス肺発がんにおけるヒストンH3K9メチル化異常の関与 Domestic conference

魏民、鈴木周五、梯アンナ、松江泰佑、鰐渕英機

第79回日本癌学会学術総会 2020.10

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有機ヒ素化合物ジメチルアルシン酸(DMA)はマウス経胎盤ばく露によりヒストンH3K9修飾を介した肺発がんを促進する Domestic conference

藤岡正喜、鈴木周五、魏民、梯アンナ、大石裕司、鰐渕英機

2020年度文部科学省新学術領域研究学術研究支援基盤形成【先端モデル動物支援プラットフォーム】若手支援技術講習会 2020.09

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ラットにおけるacetoaceto-o-toluidideの膀胱発がん促進作用 Domestic conference

魏民、行松直、鈴木周五、梯アンナ、鰐渕英機

第47回日本毒性学会学術年会 2020.06

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芳香族アミンacetoaceto-o-toluidideのラット膀胱発がん性とその機序解明 Domestic conference

魏民、鈴木周五、行松直、梯アンナ、鰐渕英機

第93回日本産業衛生学会 2020.06

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NASH肝臓発がんにおける新規マーカー候補分子の検討 Domestic conference

梯アンナ、石井真美、魏民、鈴木周五、鰐渕英機

第36回日本毒性病理学会総会及び学術集会 2020.02

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ラットにおけるBBN誘発膀胱発がんに対するo-Acetoacetotoluidideの促進効果 Domestic conference

行松直、魏民、梯アンナ、鈴木周五、鰐渕英機

第36回日本毒性病理学会総会及び学術集会 2020.02

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ジフェニルアルシン酸のマウスにおける経胎盤発がん作用 Domestic conference

魏民、鈴木周五、梯アンナ、山口貴嗣、鰐渕英機

第36回日本毒性病理学会総会及び学術集会 2020.02

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ジフェニルアルシン酸の長期毒性及びその発現機序－動物試験から得られた知見－ Domestic conference

鰐渕英機、魏民、梯アンナ、鈴木周五

第23回ヒ素シンポジウム 2019.11

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Hepatocarcinogenicity induced by prenatal exposure to diphenylarsinic acid in CD1 mice Domestic conference

2019.09

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Elevation of arginine and glucose metabolites in NASH-associated HCC Domestic conference

2019.09

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Promotion effects of acetoaceto-o-toluidide on BBN-induced bladder carcinogenesis in rats Domestic conference

2019.09

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Nicotineの膀胱発がん促進効果とその機序 Domestic conference

鈴木周五、加藤寛之、内木綾、魏民、梯アンナ、髙橋智、鰐渕英機

第34回発癌病理研究会 2019.08

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アフラトキシンB1はキメラ化したヒト化TK-NOGマウスのヒト肝領域を特異的に障害する Domestic conference

奥野高裕, 魏民, 梯アンナ, 末水洋志, 秦順一, 鰐渕英機

第46回日本毒性学会学術年会 2019.06 (一社)日本毒性学会

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Metabolome analysis in the liver tumors and tissues of NASH model TSOD mice Domestic conference

2019.05

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Acetoaceto-o-toluidideはラット膀胱上皮の細胞増殖を促進し、発がん促進作用を示す Domestic conference

奥野高裕, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

第108回日本病理学会総会 2019.05 (一社)日本病理学会

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Metabolome analysis in the liver tumors and tissues of NASH model TSOD mice Domestic conference

Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Yoshiyuki Tago, Masaki Fujioka, Min Gi and Hideki Wanibuchi

The 35th Annual Meeting of Japanese Society of Toxicologic Pathology 2019.01

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Epigenetic modification abnormality in lung carcinogenesis in mice transplacental exposure of organic arsenic compound Dimethylarsinic acid Domestic conference

Masaki Fujioka, Min Gi, Takahiro Okuno, Nao Yukimatsu, Anna Kakehashi, Yuji Oishi, Hideki Wanibuchi

The 35th Annual Meeting of Japanese Society of Toxicologic Pathology 2019.01

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Evaluation of inhibitory effects of acetozalamide on the mouse bladder carcinogenesis Domestic conference

Min Gi, Masaki Fujioka, Nao Yukimatsu, Takahiro Okuno, Takashi Yamaguchi, Anna Kakehashi, Hideki Wanibuchi

The 35th Annual Meeting of Japanese Society of Toxicologic Pathology 2019.01

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Chronic toxicity and carcinogenicity study of diphenylarsinic acid in F344 rat Domestic conference

Takashi Yamaguchi, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi

The 35th Annual Meeting of Japanese Society of Toxicologic Pathology 2019.01

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Study on toxicity and carcinogenic promoting effect to bladder of o-Acetoacetotoluidide Domestic conference

Nao Yukimatsu, Takahiro Okuno, Min Gi, Masaki Fujioka, Anna Kakehashi, Hideki Wanibuchi

The 35th Annual Meeting of Japanese Society of Toxicologic Pathology 2019.01

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BBN誘発マウス膀胱がんモデルにおけるAcetazolamideの予防効果の検討 Domestic conference

魏民, 藤岡正喜, 行松直, 奥野高裕, 山口貴嗣, 梯アンナ, 鰐渕英機

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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有機ヒ素化合物ジメチルアルシニン酸に経胎盤曝露したマウスの肺癌発症におけるエピジェネティクス修飾の異常(Epigenetic modification abnormality in lung carcinogenesis in mice transplacental exposure of organic arsenic compound Dimethylarsinic acid) Domestic conference

Fujioka Masaki, Gi Min, Okuno Takahiro, Yukimatsu Nao, Kakehashi Anna, Oishi Yuji, Wanibuchi Hideki

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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有機ヒ素化合物Dimethylarsinic acidの経胎盤ばく露によるマウス肺発がん過程におけるヒストン修飾異常 Domestic conference

藤岡正喜, 魏民, 奥野高裕, 行松直, 梯アンナ, 大石裕司, 鰐渕英機

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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マウス膀胱の発癌に関するアセタゾラミドの阻害効果の評価(Evaluation of inhibitory effects of acetazolamide on the mouse bladder carcinogenesis) Domestic conference

Gi Min, Fujioka Masaki, Yukimatsu Nao, Okuno Takahiro, Yamaguchi Takashi, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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ジフェニルアルシン酸のF344ラットにおける慢性毒性試験及び発がん性試験 Domestic conference

山口貴嗣, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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o-Acetoacetotoluidideの膀胱に対する毒性と発癌促進作用に関する研究(Study on toxicity and carcinogenic promoting effect to bladder of o-Acetoacetotoluidide) Domestic conference

Yukimatsu Nao, Okuno Takahiro, Gi Min, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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o-Acetoacetotoluidideによる膀胱に対する毒性、発がんプロモーション作用の検討 Domestic conference

行松直, 奥野高裕, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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NASHモデルTSODマウスの肝腫瘍と組織のメタボローム解析(Metabolome analysis in the liver tumors and tissues of NASH model TSOD mice) Domestic conference

Kakehashi Anna, Ishii Naomi, Okuno Takahiro, Tago Yoshiyuki, Fujioka Masaki, Gi Min, Wanibuchi Hideki

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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NASHモデルTSODマウスにおける肝臓腫瘍および肝臓組織のメタボローム解析 Domestic conference

梯アンナ, 石井真美, 奥野高裕, 多胡善幸, 藤岡正喜, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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F344系ラットにおけるdiphenylarsic acidの慢性的毒性と発癌性に関する研究(Chronic toxicity and carcinogenicity study of diphenylarsinic acid in F344 rat) Domestic conference

Yamaguchi Takashi, Gi Min, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

日本毒性病理学会講演要旨集 2019.01 日本毒性病理学会

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Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital Domestic conference

2018.12

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Induction of cell proliferation and DNA damage by Acetoaceto-o-toluidide in the urinary bladder of rats Domestic conference

Takahito Okuno, Nao Yukimatsu, Masaki Fujioka, Anna Kakehashi, Min Gi, Masayuki Kanki, Hideki Wanibuchi

The 77th Annual Meeting of the Japanese Cancer Association 2018.09

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In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats Domestic conference

Min Gi, Masaki Fujioka, Takahiro Okuno, Nao Yukimatsu, Anna Kakehashi, Hideki Wanibuchi

2018.09

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Metabolome changes in NASH liver tissue and tumors developed in metabolic syndrome model TSOD mice Domestic conference

Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Masaki Fujioka, Yoshiyuki Tago, Min Gi and Hideki Wanibuchi

The 77th Annual Meeting of the Japanese Cancer Association 2018.09

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Study of the mechanism of carcinogenesis by prenatal exposure to dimethylarsinic acid in mice Domestic conference

Masaki Fujioka, Min Gi, Takahiro Okuno, Nao Yukimatsu, Yuji Oishi, Anna Kakehashi, Hideki Wanibuchi

The 77th Annual Meeting of the Japanese Cancer Association 2018.09

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細胞障害の制御とその破綻による病態発生環境化学物質による発がんと細胞傷害・修復の破綻 Domestic conference

鰐渕英機, 魏民, 藤岡正喜, 梯アンナ, 奥野高裕

第107回日本病理学会総会 2018.06 (一社)日本病理学会

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NASH由来の肝細胞癌におけるmTORの活性化 Domestic conference

奥野高裕, 石井真美, 梯アンナ, 魏民, 鰐渕英機

第107回日本病理学会総会 2018.06 (一社)日本病理学会

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Proteomics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas Domestic conference

Anna Kakehashi, Naomi Ishii, Takahiro Okuno, Min Gi, Hideki Wanibuchi

The 107th Meeting of the Japanese Pathology Association 2018.06

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発がんリスク評価法遺伝毒性肝発がん物質超短期検出法の開発 Domestic conference

魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

第34回日本毒性病理学会 2018.01 日本毒性病理学会

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NASHモデルの病態と機序 2つのNASHモデルマウスにおける病理組織学的所見の違い Domestic conference

奥野高裕, 石井真美, 梯アンナ, 藤岡正喜, 魏民, 鰐渕英機

第34回日本毒性病理学会 2018.01 日本毒性病理学会

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NASHの肝臓組織や肝臓癌におけるプロテオーム解析 Domestic conference

梯アンナ, 奥野高裕, 藤岡正喜, 魏民, 鰐渕英機

第34回日本毒性病理学会 2018.01 日本毒性病理学会

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o-Acetoacetotoluidide(AAOT)の毒性影響の検討 Domestic conference

熊田賢次, 奥野高裕, 魏民, 藤岡正喜, 行松直, 梯アンナ, 鰐渕英機

第34回日本毒性病理学会 2018.01 日本毒性病理学会

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マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序 Domestic conference

藤岡正喜, 魏民, 奥野高裕, 熊田賢次, 梯アンナ, 大石裕司, 鰐渕英機

日本毒性病理学会講演要旨集 2018.01 日本毒性病理学会

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非アルコール性脂肪肝炎の肝臓組織や肝臓癌におけるプロテオーム解析 Domestic conference

梯アンナ, 石井真美, 藤岡正喜, 魏民, 鰐渕英機

日本癌学会総会記事 2017.09 日本癌学会

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CD1マウスにおけるジメチルアルシン酸(DMA)の胎児期ばく露による発がん性 Domestic conference

藤岡正喜, 魏民, 熊田賢次, 奥野高裕, 梯アンナ, 鰐渕英機

日本癌学会総会記事 2017.09 日本癌学会

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BBN誘発マウス膀胱発がんモデルにおけるAcetazolamideの抑制効果の検討 Domestic conference

魏民, 藤岡正喜, 梯アンナ, 奥野高裕, 香山侑弘, 熊田賢次, 鰐渕英機

日本癌学会総会記事 2017.09 日本癌学会

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BBN誘発マウス膀胱がんにおけるInk4a/Arfの役割の検討 Domestic conference

香山侑弘, 魏民, 藤岡正喜, 熊田賢次, 奥野高裕, 梯アンナ, 鰐淵英機

日本癌学会総会記事 2017.09 日本癌学会

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環境中の微量元素の毒性学ヒ素の発がんリスク評価 Domestic conference

鰐渕英機, 魏民, 藤岡正喜, 梯アンナ

The Journal of Toxicological Sciences 2017.06 (一社)日本毒性学会

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1,2-ジクロロプロパンおよびジクロロメタン複合曝露によるマウス肝臓への影響(Carcinogenic effects of concurrent administration of 1,2-dichloropropane and dichloromethane in mice) Domestic conference

藤岡正喜, 魏民, 河内聡子, 梯アンナ, 鰐渕英機

The Journal of Toxicological Sciences 2017.06 (一社)日本毒性学会

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喫煙関連肺がんを用いた網羅的リン酸化プロテオーム解析による新規治療標的分子の開発 Domestic conference

魏民, 岡田諭志, 藤岡正喜, 奥野高裕, 土井賢一郎, 梯アンナ, 鰐渕英機

日本病理学会会誌 2017.03 (一社)日本病理学会

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ヒト肝細胞癌における腫瘍幹細胞マーカーとしてのCD44v9の検索 Domestic conference

梯アンナ, 石井真美, 魏民, 佐谷秀行, 鰐渕英機

日本病理学会会誌 2017.03 (一社)日本病理学会

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1,2-ジクロロプロパンおよびジクロロメタン複合暴露におけるマウス肝発がん影響 Domestic conference

河内聡子, 魏民, 藤岡正喜, 辰己久美子, 多胡善幸, 梯アンナ, 鰐渕英機

日本毒性病理学会講演要旨集 2017.01 日本毒性病理学会

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Dimethylarsinic acidの胎仔期暴露における発がん性の検討 Domestic conference

魏民, 藤岡正喜, 辰巳久美子, 山口貴嗣, 北野光昭, 梯アンナ, 大石裕司, 鰐渕英機

日本毒性病理学会講演要旨集 2017.01 日本毒性病理学会

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CD44ノックアウトマウスにおける肝臓発がんの抑制 Domestic conference

梯アンナ, 辰己久美子, 奥野高裕, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2017.01 日本毒性病理学会

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1,2-DCPおよびDCM複合曝露がマウス肝発がんを促進する Domestic conference

河内聡子, 魏民, 藤岡正喜, 辰己久美子, 梯アンナ, 土井賢一郎, 鰐渕英機

日本癌学会総会記事 2016.10 日本癌学会

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ハムスター二段階発がんモデルにおける1,2-DCPの発がん修飾作用 Domestic conference

魏民, 辰己久美子, 藤岡正喜, 河内聡子, 熊田賢次, 梯アンナ, 鰐渕英機

日本癌学会総会記事 2016.10 日本癌学会

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mTOR阻害剤エベロリムスと抗PD-L1抗体の併用療法による抗腫瘍効果 Domestic conference

平山幸良, 魏民, 藤岡正喜, 梯アンナ, 鰐渕英機

日本癌学会総会記事 2016.10 日本癌学会

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EGFR・ALK陰性原発性肺腺癌を用いた網羅的リン酸化プロテオーム解析 Domestic conference

岡田諭志, 魏民, 山野荘太郎, 土井賢一郎, 梯アンナ, 藤岡正喜, 鰐渕英機

日本癌学会総会記事 2016.10 日本癌学会

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CD44ノックアウトマウスにおける肝臓腫瘍の発生の抑制 Domestic conference

梯アンナ, 石井真美, 辰己久美子, 魏民, 佐谷秀行, 鰐渕英機

日本癌学会総会記事 2016.10 日本癌学会

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短期間に後腹膜絨毛癌の肺転移により出血死した壮年男性の剖検例 Domestic conference

土井賢一郎, 石井真美, 武貞博治, 山本朋納, 魏民, 梯アンナ, 鰐渕英機

日本病理学会会誌 2016.04 (一社)日本病理学会

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メタボリックシンドロームモデルマウスにおける肝腫瘍の発生メカニズムの検討 Domestic conference

石井真美, 梯アンナ, 辰己久美子, 藤岡正喜, 土井賢一郎, 魏民, 鰐渕英機

日本病理学会会誌 2016.04 (一社)日本病理学会

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ヌードマウス皮下腫瘍モデルにおけるCNPY2及びCACHD1ノックダウンにより肝細胞癌の抑制(CNPY2 and CACHD1 knockdown inhibits growth of liver cancer xenografts in nude mice) Domestic conference

梯アンナ, 石井真美, 辰己久美子, 藤岡正喜, 魏民, 鰐渕英機

日本病理学会会誌 2016.04 (一社)日本病理学会

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「薬毒同源」のヒ素化合物　環境化学物質および医薬品としての二面性発がんモデルを用いたヒ素発がん性の証明とその機序の解明 Domestic conference

鰐渕英機, 魏民, 梯アンナ, 藤岡正喜

日本薬学会年会要旨集 2016.03 (公社)日本薬学会

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CD44ノックアウトマウスを用いた二段階発がん性試験における肝臓腫瘍の発生の検討 Domestic conference

梯アンナ, 石井真美, 辰己久美子, 魏民, 佐谷秀行, 鰐渕英機

日本毒性病理学会講演要旨集 2016.01 日本毒性病理学会

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メタボリックシンドロームモデルマウス(TSODマウス)における肝腫瘍の発生メカニズムの検討 Domestic conference

石井真美, 梯アンナ, 辰己久美子, 藤岡正喜, 土井賢一郎, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2016.01 日本毒性病理学会

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ダンマル樹脂の雄性F344ラットにおける肝発がん性 Domestic conference

房赫, 魏民, 藤岡正喜, 辰巳久美子, 河内聡子, 土井賢一郎, 石井真美, 梯アンナ, 山野荘太郎, 鰐渕英機

日本毒性病理学会講演要旨集 2016.01 日本毒性病理学会

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Mcl-1蛋白を標的とする低分子抗がん物質の毒性と有効性の評価 Domestic conference

土井賢一郎, 鰐渕英機, 魏民, 梯アンナ, 石井真美, 山野荘太郎

日本毒性病理学会講演要旨集 2016.01 日本毒性病理学会

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ヌードマウス皮下腫瘍モデルにおけるCNPY2およびCACHD1ノックダウンによる肝発がんの抑制 Domestic conference

梯アンナ, 石井真美, 楠元久美子, 藤岡正喜, 魏民, 鰐渕英機

日本癌学会総会記事 2015.10 日本癌学会

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ダンマル樹脂のF344ラットを用いたがん原性試験　ダンマル樹脂はラット肝発がん物質である Domestic conference

魏民, 山野荘太郎, 藤岡正喜, 梯アンナ, 立花大和, 土井賢一郎, 鰐渕英機

日本癌学会総会記事 2015.10 日本癌学会

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ラット肝発がんにおけるValerianの抑制作用 Domestic conference

石井真美, 梯アンナ, 魏民, 鰐渕英機

日本癌学会総会記事 2015.10 日本癌学会

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ラットにおける2-エトキシ-2-メチルプロパンの肝臓発腫瘍性機序の解明 Domestic conference

梯アンナ, 萩原昭裕, 今井則夫, 魏民, 福島昭治, 鰐渕英機

The Journal of Toxicological Sciences 2015.06 (一社)日本毒性学会

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プロテオーム解析によるヒトNASH肝細胞癌の分子メカニズムの検討 Domestic conference

石井真美, 梯アンナ, 楠元久美子, 藤岡正喜, 魏民, 桑江優子, 大澤政彦, 鰐渕英機

日本病理学会会誌 2015.03 (一社)日本病理学会

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ヒト肝細胞癌における新規分子マーカーとしてCNPY2およびCACHD1の同定 Domestic conference

梯アンナ, 桑江優子, 石井真美, 魏眠, 藤岡正喜, 鰐渕英機

日本病理学会会誌 2015.03 (一社)日本病理学会

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ラット肝発がんにおけるValerianの予防効果 Domestic conference

石井真美, 梯アンナ, 魏民, 福島昭治, 鰐渕英機

日本毒性病理学会講演要旨集 2015.01 日本毒性病理学会

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ハムスターBOP二段階膵胆管発がんモデルを用いた1,2-dichloropropane(1,2-DCP)の発がん修飾作用の検討 Domestic conference

下村衣里, 魏民, 藤岡正喜, 山野荘太郎, 梯アンナ, 鰐渕英機

日本毒性病理学会講演要旨集 2015.01 日本毒性病理学会

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肝細胞癌における新規分子マーカーとしてCNPY2およびCACHD1の同定 Domestic conference

梯アンナ, 石井真美, 魏民, 藤岡正喜, 鰐渕英機

日本毒性病理学会講演要旨集 2015.01 日本毒性病理学会

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ヒト肝細胞癌における新治療ターゲットの検索　CNPY2及びCACHD1(CNPY2 and CACHD1 as potential molecular therapeutic targets for human liver cancer) Domestic conference

梯アンナ, 石井真美, 桑江優子, 房赫, 藤岡正喜, 魏民, 鰐渕英機

日本癌学会総会記事 2014.09 日本癌学会

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ヒトNASH肝細胞癌におけるプロテオーム解析を用いた分子メカニズムの検討(Analysis of potential molecular candidates as cancer biomarkers and molecular mechanisms of NASH carcinogenesis) Domestic conference

石井真美, 梯アンナ, 桑江優子, 大澤政彦, 魏民, 鰐渕英機

日本癌学会総会記事 2014.09 日本癌学会

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ハムスター化学発がんモデルを用いた1,2-dichloropropaneの発がん修飾作用の検討(Evaluation of the modifying effects of 1,2-dichloropropane on hepatobilliary and pancreatic carcinogenesis in hamsters) Domestic conference

魏民, 下村衣里, 藤岡正喜, 山野荘太郎, 梯アンナ, 石井真美, 武下正憲, 房赫, 鰐渕英機

日本癌学会総会記事 2014.09 日本癌学会

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gpt deltaラットを用いた2-AAFの肝発がん性および変異原性の包括的評価モデルの検討(Examination of in vivo mutagenicity and carcinogenicity of 2-AAF in gpt delta rats) Domestic conference

藤岡正喜, 魏民, 山野荘太郎, 梯アンナ, 石井真美, 下村衣里, 三島胡桃, 房赫, 鰐渕英機

日本癌学会総会記事 2014.09 日本癌学会

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化学発がん物質のリスク評価における閾値問題 Domestic conference

福島昭治, 魏民, 梯アンナ, 鰐渕英機

The Journal of Toxicological Sciences 2014.07 (一社)日本毒性学会

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プロテオーム解析による胃癌幹細胞関連マーカーの同定 Domestic conference

森崎珠実, 八代正和, 梯アンナ, 笠島裕明, 増田剛, 木下春人, 櫻井克宣, 豊川貴弘, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 鰐渕英機, 平川弘聖

日本分子腫瘍マーカー研究会誌 2014.04 日本分子腫瘍マーカー研究会

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ヒト肝細胞癌におけるLC-MS/MS及びin vitro機能解析を用いた新規特異的候補分子ターゲットの検討 Domestic conference

梯アンナ, 桑江優子, 石井真美, 魏民, 鰐渕英機

日本病理学会会誌 2014.03 (一社)日本病理学会

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肝発がんにおけるLC-Ms/Ms及びin vitro機能解析を用いた新規特異的候補分子の検討 Domestic conference

梯アンナ, 石井真美, 藤岡正喜, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2014.01 日本毒性病理学会

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シリアンハムスターにおける1,2-dichrolopropanの強制経口投与による肝毒性とその発現機序の検討 Domestic conference

魏民, 山野荘太郎, 藤岡正喜, 梯アンナ, 下村衣里, 神吉將之, 鰐渕英機

日本毒性病理学会講演要旨集 2014.01 日本毒性病理学会

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DMAVおよびiAsIIIのラット膀胱、肝臓における変異原性の解析 Domestic conference

下村衣里, 藤岡正喜, 魏民, 山野荘太郎, 梯アンナ, 串田昌彦, 鰐渕英機

日本毒性病理学会講演要旨集 2014.01 日本毒性病理学会

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ラット中期多臓器発がん性試験法を用いたDPAA(diphenyl arsenic acid)の発がん修飾作用の検討(Evaluation of carcinogenesity of DPAA in a rat medium-term multi-organ carcinogenicity bioassay) Domestic conference

奥村真衣, 藤岡正喜, 山野荘太郎, 梯アンナ, 魏民, 鰐渕英機

日本癌学会総会記事 2013.10 日本癌学会

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ヒト肝細胞癌における新規特異的候補分子ターゲットの機能解析(Functional analysis of novel molecular candidates as therapeutic targets for human liver cancer) Domestic conference

梯アンナ, 桑江優子, 加藤実, 山野荘太郎, 神吉将之, 魏民, 若狭研一, 鰐渕英機

日本癌学会総会記事 2013.10 日本癌学会

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ヒト浸潤性膵管癌における新規バイオマーカー候補分子の検討(Identification of Novel Protein Biomarkers for Human Pancreatic Ductal Adenocarcinoma) Domestic conference

桑江優子, 梯アンナ, 魏民, 若狭研一, 鰐渕英機

日本癌学会総会記事 2013.10 日本癌学会

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gpt deltaラットを用いたDMA(V)、iAs(III)の変異原性および遺伝子変化の検討(Evaluation of in vivo mutagenicity of DMA(V) and iAs(III) in gpt delta rats) Domestic conference

藤岡正喜, 魏民, 山野荘太郎, 奥村真衣, 下村衣里, 梯アンナ, 鰐渕英機

日本癌学会総会記事 2013.10 日本癌学会

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1,2-ジクロロプロパンのマウスおよびハムスターの肝臓における代謝および毒性発現機序の検討(Evaluation of the metabolic basis of hepatotoxicity of 1,2- dichloropropane in male B6C3F1 mice and Syrian hamsters) Domestic conference

魏民, 山野荘太郎, 藤岡正喜, 加藤実, 武下正憲, 梯アンナ, 鰐渕英機

日本癌学会総会記事 2013.10 日本癌学会

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胃癌幹細胞のプロテオーム解析(Comparative proteomics analysis of cancer stem cells in gastric cancer cells) Domestic conference

森崎珠実, 八代正和, 梯アンナ, 木下春人, 福岡達成, 櫻井克宣, 豊川貴弘, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 鰐渕英機, 平川弘聖

日本癌学会総会記事 2013.10 日本癌学会

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肺腺癌におけるPTRF/Cavin-1発現と予後との関連(Expression of PTRF/Cavin-1 is associated with poor prognosis of lung adenocarcinoma) Domestic conference

井上英俊, 魏民, 小松弘明, 山野荘太郎, 梯アンナ, 西山典利, 鰐渕英機

日本癌学会総会記事 2013.10 日本癌学会

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プロテオーム解析による胃癌幹細胞関連マーカーの同定 Domestic conference

森崎珠実, 八代正和, 梯アンナ, 笠島裕明, 増田剛, 木下春人, 櫻井克宣, 豊川貴弘, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 鰐渕英機, 平川弘聖

日本分子腫瘍マーカー研究会プログラム・講演抄録 2013.09 日本分子腫瘍マーカー研究会

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プロテオーム解析を用いた胃癌幹細胞関連蛋白の同定とその臨床的意義 Domestic conference

森崎珠実, 八代正和, 梯アンナ, 櫻井克宣, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 鰐渕英機, 平川弘聖

日本消化器外科学会総会 2013.07 (一社)日本消化器外科学会

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ラット肝における肝臓癌原性および毒性フェノタイプを予測できる遺伝子マーカーセットの同定(Identification of gene marker sets that could predict the hepatocarcinogenicity and toxic phenotype in the rat liver) Domestic conference

Kanki Masayuki, Wein Min, Kakehashi Anna, Yamano Shotaro, Wanibuchi Hideki

Journal of Toxicologic Pathology 2013.06 日本毒性病理学会

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ラットにおける化学物質の膀胱癌原性を予測するためのmicroRNAマーカーの同定(Identification of MicroRNA Markers for Predicting Bladder Carcinogenicity of Chemicals in Rats) Domestic conference

Gi Min, Yamano Shotaro, Kato Minoru, Fujioka Masaki, Kinoshita Anna, Kanki Masayuki, Wanibuchi Hideki

Journal of Toxicologic Pathology 2013.06 日本毒性病理学会

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マウス肺SCCにおける気管支肺胞幹細胞のcancer initiating cellとしての可能性(Possibility of Cancer Initiating Cell of Bronchiolar Alveolar Stem Cell for Mice Lung SCC) Domestic conference

Yamano Shotaro, Wei Min, Fujioka Masaki, Kakehashi Anna, Wanibuchi Hideki

Journal of Toxicologic Pathology 2013.06 日本毒性病理学会

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ラット肝臓におけるethyl tertiary-butyl etherの発癌性の作用機序　CAR、PXRおよびPPARの活性化を介する酸化ストレス誘導の証拠(Mode of action of ethyl tertiary-butyl ether tumorigenicity in the rat liver: Evidence for oxidative stress induction via activation of CAR, PXR and PPARs) Domestic conference

Kakehashi Anna, Hagiwara Akihiro, Imai Norio, Wei Min, Nagano Kasuke, Fukushima Shoji, Wanibuchi Hideki

Journal of Toxicologic Pathology 2013.06 日本毒性病理学会

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原発性肺腺癌組織におけるNapsin Aの発現と予後の相関 Domestic conference

井上英俊, 西山典利, 魏民, 梯アンナ, 花田庄司, 小松弘明, 鰐渕英機

日本病理学会会誌 2013.04 (一社)日本病理学会

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ヒト肝細胞癌における特異的候補分子の機能解析 Domestic conference

鰐渕英機, 桑江優子, 魏民, 若狭研一, 梯アンナ

日本病理学会会誌 2013.04 (一社)日本病理学会

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胃癌幹細胞関連蛋白の同定と臨床的意義 Domestic conference

森崎珠実, 八代正和, 渡邊真央, 大北仁裕, 福岡達成, 長谷川毅, 吉井真美, 櫻井克宣, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 梯アンナ, 鰐渕英機, 平川弘聖

日本外科学会雑誌 2013.03 (一社)日本外科学会

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胃癌幹細胞関連蛋白のプロテオーム解析と臨床的意義の検討 Domestic conference

森崎珠実, 八代正和, 木下春人, 渡邊真央, 大北仁裕, 福岡達成, 長谷川毅, 櫻井克宣, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 梯アンナ, 鰐渕英機, 平川弘聖

日本胃癌学会総会記事 2013.02 (一社)日本胃癌学会

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ラットにおける非遺伝毒性肝発がん物質と毒性フェノタイプを予測できる遺伝子マーカーセットの探索 Domestic conference

神吉将之, 魏民, 梯アンナ, 山野荘太朗, 鰐渕英機

日本毒性病理学会講演要旨集 2013.01 日本毒性病理学会

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ラットにおける2-エトキシ-2-メチルプロパンの肝臓発腫瘍性機序の解明 Domestic conference

梯アンナ, 萩原昭裕, 今井則夫, 魏眠, 長野嘉介, 福島昭治, 鰐渕英機

日本毒性病理学会講演要旨集 2013.01 日本毒性病理学会

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マウス肺扁平上皮癌モデルにおける気管支肺胞幹細胞のcancer initiating cellとしての可能性 Domestic conference

山野荘太郎, 魏民, 藤岡正喜, 梯アンナ, 岡部恭子, 武下正憲, 鰐渕英機

日本毒性病理学会講演要旨集 2013.01 日本毒性病理学会

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膀胱発がん物質の早期検出microRNAマーカーの検討 Domestic conference

魏民, 山野荘太郎, 加藤実, 藤岡正喜, 梯アンナ, 神吉将之, 鰐渕英機

日本毒性病理学会講演要旨集 2013.01 日本毒性病理学会

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メチオニンスルホキシドによるNASHマウスの肝発がん促進　フリーラジカル機構によるCpGメチル化との関わり(Methionine Sulfoxide Stimulates Hepatocarcinogenesis in NASH Mouse: Role of Free Radical-mediated DNA Methylation) Domestic conference

河井一明, 李云善, 梯アンナ, 鰐渕英機, 大津山彰, 葛西宏

日本癌学会総会記事 2012.08 日本癌学会

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マウス肺扁平上皮癌の発がん過程早期における気管支肺胞幹細胞の関与(Involvement of Bronchiolar Alveolar Stem Cell for Early Stage of Carcinogenic Process in Mice Lung SCC) Domestic conference

山野荘太郎, 魏民, 田尻正喜, 梯アンナ, 岡部恭子, 奥村真衣, 多胡善幸, 鰐渕英機

日本癌学会総会記事 2012.08 日本癌学会

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プロテオーム解析による新規肺神経内分泌癌のバイオマーカー検索(Proteomics of human lung neuroendocrine carcinoma to detect potential biomarkers applicable in clinical practice) Domestic conference

小松弘明, 西山典利, 山野荘太郎, 花田庄司, 井上英俊, 梯アンナ, 魏民, 鰐渕英機

日本癌学会総会記事 2012.08 日本癌学会

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ヒト肝細胞癌における特異的候補分子のピンポイントターゲッティング(Identification of Novel Molecular Targets for Human liver Cancer) Domestic conference

梯アンナ, 桑江優子, 山野荘太郎, 魏民, 謝暁利, 若狭研一, 鰐渕英機

日本癌学会総会記事 2012.08 日本癌学会

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Steroid Sulfataseは膀胱癌の予後予測因子である(Steroid sulfatase predicts the progression of bladder cancer) Domestic conference

加藤実, 魏民, 田尻正喜, 山野荘太郎, 梯アンナ, 仲谷達也, 鰐渕英機

日本癌学会総会記事 2012.08 日本癌学会

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FFPE標本を用いたヒト浸潤性膵管癌のプロテオーム解析(Proteomics of Human Pancreatic Ductal Adenocarcinoma using FFPE Section) Domestic conference

桑江優子, 梯アンナ, 魏民, 若狹研一, 鰐渕英機

日本癌学会総会記事 2012.08 日本癌学会

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BBN誘発マウス膀胱発がん過程における幹細胞関連タンパク質の発現(Expressions of cancer stem cell-related proteins in BBN-induced mouse bladder carcinogenesis) Domestic conference

魏民, 山野荘太郎, 加藤実, 梯アンナ, 神吉将之, 謝暁利, 鰐渕英機

日本癌学会総会記事 2012.08 日本癌学会

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癌幹細胞様SP細胞と低酸素細胞のプロテオーム解析(Proteome analysis of cancer stem cell-like SP and hypoxia-resistant cancer cell lines) Domestic conference

森崎珠実, 八代正和, 梯アンナ, 福岡達成, 青松直撥, 長谷川毅, 平川俊基, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 鰐渕英機, 平川弘聖

日本癌学会総会記事 2012.08 日本癌学会

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プロテオーム解析を用いたスキルス胃癌の癌幹細胞に関与する分子 Domestic conference

森崎珠実, 八代正和, 櫻井克宣, 久保尚士, 田中浩明, 六車一哉, 大平雅一, 梯アンナ, 鰐渕英機, 平川弘聖

日本消化器外科学会総会 2012.07 (一社)日本消化器外科学会

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単純性骨嚢腫内容液のプロテオーム解析　長管骨症例と踵骨症例の比較 Domestic conference

高田潤, 梯アンナ, 星学, 大戎直人, 中村博亮, 鰐渕英機

中部日本整形外科災害外科学会雑誌 2012.04 中部日本整形外科災害外科学会

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ヒト肝臓癌のプロテオーム解析を用いた新規バイオマーカー候補分子の検討 Domestic conference

梯アンナ, 謝暁利, 山野荘太郎, 魏民, 鰐渕英機

日本病理学会会誌 2012.03 (一社)日本病理学会

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癌のゲノム医療チェルノブイリ原発事故後の長期低用量放射線暴露による膀胱病変とその発生メカニズム Domestic conference

梯アンナ, Romanenko Alina, 森村圭一朗, 魏民, 鰐渕英機, 福島昭治

日本泌尿器科学会雑誌 2012.03 (一社)日本泌尿器科学会

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非遺伝毒性肝発がん物質のラット肝臓における遺伝子発現解析 Domestic conference

神吉将之, 魏民, 梯アンナ, 山野荘太朗, 鰐渕英機

日本毒性病理学会講演要旨集 2012.02 日本毒性病理学会

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マウス肝がんにおけるIQ促進作用のメカニズムの検討(IQ Promotes Mouse Hepatocarcinogenesis by Activating Transforming Growth Factor-β and Wnt/β-Catenin Signaling Pathways) Domestic conference

Xie Xiao-Li, 魏民, 梯アンナ, 田尻正喜, 岡部恭子, 多胡善幸, 鰐渕英機

日本毒性病理学会講演要旨集 2012.02 日本毒性病理学会

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ヒト肝臓癌のプロテオーム解析を用いた新規バイオマーカー候補分子の検索 Domestic conference

梯アンナ, 山野荘太郎, 魏民, 謝暁利, 武下正憲, 串田昌彦, 鰐渕英機

日本毒性病理学会講演要旨集 2012.02 日本毒性病理学会

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メチオニンスルホキシドによるNASHマウス肝発がんの促進　フリーラジカル機構によるCpGメチル化との関わり(Methionine sulfoxide stimulates liver carcinogenesis in NASH mice: the role of free radical-mediated CpG methylation) Domestic conference

河井一明, 李云善, 宋明芬, 梯アンナ, 鰐渕英機, 大津山彰, 葛西宏

日本癌学会総会記事 2011.09 日本癌学会

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マウス肝発がんにおけるIQ促進作用のメカニズムの検討(IQ promotes mice hepatocarcinogenesis through activations of TGF-β and Wnt/β-catenin signaling pathways) Domestic conference

謝暁利, 魏民, 梯アンナ, 田尻正喜, 山野荘太郎, 神吉将之, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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ヒト肝臓腫瘍の比較的プロテオーム解析及び新規バイオマーカ候補分子の検討(Comparative proteome analysis and identification of novel biomarkers for human liver cancer) Domestic conference

梯アンナ, 石井真美, 山野荘太郎, 魏民, 岡部恭子, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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コウジ酸およびIQのin vivo変異原性および発がん修飾作用の検討(Examination of in vivo mutagenicities and carcinogenicities of Kojic acid and IQ in the rats) Domestic conference

田尻正喜, 魏民, 岡部恭子, 山野荘太郎, 梯アンナ, 神吉将之, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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NASH関連肝癌発症モデルであるSTAMマウスの有用性評価(Evaluation of usefulness of STAM mice as NASH-associated HCC model) Domestic conference

山野荘太郎, 魏民, 石井真美, 梯アンナ, 多胡善幸, 謝暁利, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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Carbonic anhydrase 2は膀胱がんの新規浸潤関連因子である(Identification of carbonic anhydrase 2, an invasion-associated protein in urinary bladder cancer) Domestic conference

魏民, 山野荘太郎, 加藤実, 梯アンナ, 多胡善幸, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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肺扁平上皮癌におけるプロテオーム解析と臨床病理学的検討(Proteome analysis and clinicopathologic examination in human lung squamous cell carcinoma) Domestic conference

花田庄司, 西山典利, 山野荘太郎, 小松弘明, 丁奎光, 梯アンナ, 魏民, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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肺大細胞神経内分泌癌(LCNEC)の新たなバイオマーカーの同定(Identification of novel biomarkers of human lung large cell neuroendocrine carcinoma) Domestic conference

小松弘明, 西山典利, 山野荘太郎, 花田庄司, 丁奎光, 梯アンナ, 魏民, 鰐渕英機

日本癌学会総会記事 2011.09 日本癌学会

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ハザードからリスク評価へ　遺伝毒性の新たなる前進遺伝毒性発がん物質における閾値の存在 Domestic conference

魏民, 梯アンナ, 福島昭治, 鰐渕英機

The Journal of Toxicological Sciences 2011.06 (一社)日本毒性学会

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糖尿病ラットの糸球体における細胞骨格関連蛋白質のプロテオミクス解析 Domestic conference

仲谷慎也, 石村栄治, 梯アンナ, 嶋英明, 森克仁, 稲葉雅章, 鰐渕英機

日本腎臓学会誌 2011.05 (一社)日本腎臓学会

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肺扁平上皮癌におけるプロテオーム解析と臨床病理学的検討 Domestic conference

花田庄司, 魏民, 丁奎光, 梯アンナ, 西山典利, 鰐渕英機

日本病理学会会誌 2011.03 (一社)日本病理学会

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プロテオーム解析による膀胱癌バイオマーカーの検討 Domestic conference

加藤実, 魏民, 山野荘太郎, 仲谷慎也, 梯アンナ, 鰐渕英機

日本病理学会会誌 2011.03 (一社)日本病理学会

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ヒト剖検例の単離糸球体を用いた糖尿病性腎症のプロテオーム解析 Domestic conference

仲谷慎也, 魏民, 山野荘太郎, 石井真美, 梯アンナ, 鰐渕英機

日本病理学会会誌 2011.03 (一社)日本病理学会

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QSTAR Elite LC-MS/MSを用いたヒト肺腺癌におけるプロテオーム解析 Domestic conference

小松弘明, 丁奎光, 梯アンナ, 花田庄司, 魏民, 西山典利, 鰐渕英機

日本病理学会会誌 2011.03 (一社)日本病理学会

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B6C3F1マウスの2期肝細胞癌発癌モデルにおけるIQの促進作用(Promotion effects of IQ in a two-stage hepatocarcinogenesis model of B6C3F1 mice) Domestic conference

Xiaoli Xie, 魏民, 梯アンナ, 山野荘太郎, 金川明裕, 田尻正喜, 鰐渕英機

日本病理学会会誌 2011.03 (一社)日本病理学会

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膀胱がん新規浸潤因子Carbonic anhydrase 2の同定 Domestic conference

魏民, 山野荘太郎, 加藤実, 梯アンナ, 鰐渕英機

日本病理学会会誌 2011.03 (一社)日本病理学会

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糖尿病ラットの糸球体における細胞骨格関連蛋白の検討 Domestic conference

仲谷慎也, 山野荘太郎, 梯アンナ, 金川明裕, 花田庄司, 石村栄治, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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マウス肺扁平上皮癌の早期発癌過程における気管支肺胞幹細胞の関与 Domestic conference

山野荘太郎, 魏民, 梯アンナ, 多胡善幸, 丁奎光, 陳慶義, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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マウス肝発がんにおける新規バイオマーカー候補分子の検討 Domestic conference

梯アンナ, 石井真美, 山野荘太郎, 魏民, 神吉将之, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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マウス二段階肝発がんモデルを用いたIQの肝発がん性の検討(Promotion effects of 2-amino-3-methylimidazo [4,5-f] quinoline in a two-stage hepatocarcinogenesis model of B6C3F1 mice) Domestic conference

謝暁利, 魏民, 梯アンナ, 山田貴宣, 大保ゆみ, 林修次, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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NASH-HCC発症STAMマウスにおける病理組織学的解析 Domestic conference

武下正憲, 山野荘太郎, 梯アンナ, 石井真美, 蟹江尚平, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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IQの低用量域における発がん性　閾値の存在 Domestic conference

魏民, 梯アンナ, 石井真美, 北野光昭, 福島昭治, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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Diphenylarsinic acidのラットにおける慢性毒性および発がん性の検討 Domestic conference

田尻正喜, 魏民, 梯アンナ, 山野荘太郎, 加藤実, 鰐渕英機

日本毒性病理学会講演要旨集 2011.01 日本毒性病理学会

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質量分析に基づいた肺扁平上皮癌のプロテオーム特性(Mass spectrometry-based proteomic profiling of primary squamous cell lung carcinoma) Domestic conference

花田庄司, 梯アンナ, 山野荘太郎, 丁奎光, 魏民, 西山典利, 鰐淵英機

日本癌学会総会記事 2010.08 日本癌学会

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マウス肝発がんにおけるプロテオーム解析を用いた新たなバイオマーカーの検討(Evaluation of novel protein biomarkers in mice hepatocarcinogenesis) Domestic conference

梯アンナ, 石井真美, 山野荘太郎, 大保ゆみ, 林修次, 鰐渕英機

日本癌学会総会記事 2010.08 日本癌学会

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ヒト肺腺癌の有用な新規腫瘍マーカーとしてのAGR2(AGR2 as a novel useful biomarker of human lung adenocarcinoma) Domestic conference

丁奎光, 梯アンナ, 山野荘太郎, 花田庄司, 魏民, 西山典利, 鰐渕英機

日本癌学会総会記事 2010.08 日本癌学会

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NTCU誘発異型細気管支上皮細胞における細胞表面マーカーの同定(Identification of cell surface markers in NTCU-induced dysplastic bronchiole epithelium) Domestic conference

山野荘太郎, 梯アンナ, 丁奎光, 花田庄司, 蟹江尚平, 鰐渕英機

日本癌学会総会記事 2010.08 日本癌学会

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自然発症2型糖尿病モデルラットの単離糸球体を用いたプロテオーム解析 Domestic conference

仲谷慎也, 石村栄治, 石井真美, 山野荘太郎, 梯アンナ, 魏民, 森克仁, 西沢良記, 鰐渕英機

日本腎臓学会誌 2010.05 (一社)日本腎臓学会

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QSTAR Elite LC-MS/MSを用いたマウス肺腫瘍におけるプロテオーム解析 Domestic conference

山野荘太郎, 梯アンナ, 石井真美, 魏民, 鰐渕英機

日本病理学会会誌 2010.03 (一社)日本病理学会

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ベリニ管癌の一剖検例 Domestic conference

石井真美, 魏民, 梯アンナ, 山野荘太郎, 若狭研一, 鰐渕英機

日本病理学会会誌 2010.03 (一社)日本病理学会

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ヒトプロト型c-Ha-rasトランスジェニックラットを用いた浸潤性膀胱がんモデルの開発 Domestic conference

魏民, 山野荘太郎, 石井真美, 梯アンナ, 鰐渕英機

日本病理学会会誌 2010.03 (一社)日本病理学会

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ラット炎症性大腸がんモデルにおけるプロポリスの修飾作用の検討 Domestic conference

則座由依, 梯アンナ, 山野荘太郎, 大保ゆみ, 蟹江尚平, 鰐渕英機

日本毒性病理学会講演要旨集 2010.02 日本毒性病理学会

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QSTAR Elite LC-MS/MSを用いたマウス肺腫瘍におけるプロテオーム解析 Domestic conference

山野荘太郎, 梯アンナ, 多胡善幸, 山田貴宣, 丁奎光, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2010.02 日本毒性病理学会

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BBN-誘発ラット膀胱癌発癌の初期段階におけるイソロイシンとロイシンの影響の喪失(Lack of effects of isoleucine and leucine at early stage of BBN-induced rat bladder carcinogenesis) Domestic conference

謝暁利, 山野荘太郎, 梯アンナ, 則座由依, 陳慶義, 鰐渕英機

日本毒性病理学会講演要旨集 2010.02 日本毒性病理学会

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2型糖尿病自然発症ラットを用いた糖尿病の発がんに及ぼす影響の検討 Domestic conference

石井真美, 魏民, 梯アンナ, 山野荘太郎, 仲谷慎也, 鰐渕英機

日本毒性病理学会講演要旨集 2010.02 日本毒性病理学会

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2型糖尿病モデルラットの糸球体を用いたプロテオーム解析 Domestic conference

仲谷慎也, 石井真美, 山野荘太郎, 梯アンナ, 魏民, 鰐渕英機

日本毒性病理学会講演要旨集 2010.02 日本毒性病理学会

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Outline of collaborative research (seeds)

Biochemical and molecular-biological analysis of carcinogenesis mechanisms

2005-

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Request for collaborative research：Universities etc. Research institutes

Type of research exchange：Contract research

Core knowledge, technology, information etc：Chemical carcinogenesis, molecular and toxicologic pathology, biochemistry

Study on mechanisms of chemical carcinogenesis:searching for biomarkers by analysing proteomics of preneplastic and cancer lesions
Investigation of markers and mechanisms of virus and MASH-associated liver cancer

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Request for collaborative research：Universities etc. Research institutes

Type of research exchange：Joint research
Hormesis and dose response-mediated mechanisms in carcinogenesis

1999-

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Request for collaborative research：Universities etc. Research institutes

Type of research exchange：Contract research,　Joint research,　Lecture

Application fields / methods etc：Recently the idea of hormesis, a biphasic dose-response relationship in which a chemical exerts opposite effects dependent on the dose, has attracted interest in the field of carcinogenesis.

Core knowledge, technology, information etc：chemical carcinogenesis, cancer risk assessment, molecular,toxicologic pathology

Recently the idea of hormesis has attracted interest in the field of carcinogenesis.
Elucidation of novel early biomarkers and carcinogenic mechanisms of invasive pancreatic ductal carcinoma

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Request for collaborative research：Universities etc. Research institutes

Type of research exchange：Joint research

Grant-in-Aid for Scientific Research

Elucidation of diagnostic markers for early detection of invasive pancreatic ductal carcinoma and development of new organoid culture model

Grant-in-Aid for Scientific Research(C) 2025
Elucidation of diagnostic markers for early detection of invasive pancreatic ductal carcinoma and development of new organoid culture model

Grant-in-Aid for Scientific Research(C) 2024
ナノマテリアルの物理化学的性状を考慮した肺、胸腔及び全身臓器における有害性の評価ならびに新規in vitro予測手法の開発（23KD1002）

化学物質リスク研究事業 2023
Elucidation of diagnostic markers for early detection of invasive pancreatic ductal carcinoma and development of new organoid culture model

Grant-in-Aid for Scientific Research(C) 2023
ナノマテリアルの物理化学的性状を考慮した肺、胸腔及び全身臓器における有害性の評価ならびに新規in vitro予測手法の開発　(20KD1003)

化学物質リスク研究事業 2020.04
Investigation of markers and mechanisms of NASH-associated liver cancer

Grant-in-Aid for Scientific Research(C) 2017.04
Pinpoint targeting of hepatocellular carcinoma for new therapeutic application

Grant-in-Aid for Scientific Research(C) 2012.04
Proteomics of Human Pancreatic Ductal Adenocarcinoma using FFPE Sections

Grant-in-Aid for Scientific Research(C) 2011.04
Proteome analysis of isolated glomeruli of diabetic nephropathy

Grant-in-Aid for Scientific Research(C) 2010.04
The strategic proteome analysis for the development of early diagnosis and therapeutic target of primary lung adenocarcinoma

Grant-in-Aid for Scientific Research(C) 2010.04
Investigation of hepatocarcinogenesis mechanisms : targeted proteomics of liver preneoplastic lesions and tumors

Grant-in-Aid for Young Scientists(B) 2007.04

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Charge of on-campus class subject

病理学修行実習

2024 Undergraduate
肝発がんの分子機構とバイオマーカー

2024 Graduate school
原因と病態1　病理学：副腎疾患

2024 Undergraduate
原因と病態1　病理学：膵島疾病-糖尿病と膵島腫瘍

2024 Undergraduate
原因と病態1　病理学：口腔・唾液腺・食道疾患

2024
原因と病態1　病理学：視床・下垂体・甲状腺疾患

2024 Undergraduate
病理学：口腔・唾液腺・食道疾患

2023 Undergraduate
病理学修行実習

2023 Undergraduate
肝発がんの分子機構とバイオマーカー

2023 Graduate school
病理学：視床・下垂体・甲状腺疾患

2023 Undergraduate

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