Updated on 2025/11/25

写真a

 
KIM DongHo
 
Organization
Graduate School of Human Life and Ecology Division of Human Life and Ecology Associate Professor
School of Human Life and Ecology Department of Nutrition
Title
Associate Professor
Affiliation
Institute of Human Life and Ecology
Affiliation campus
Morinomiya Campus

Position

  • Graduate School of Human Life and Ecology Division of Human Life and Ecology 

    Associate Professor  2022.04 - Now

  • School of Human Life and Ecology Department of Nutrition 

    Associate Professor  2022.04 - Now

Degree

  • Doctor of Agriculture ( Tohoku University )

Research Areas

  • Life Science / Nutrition science and health science  / Amino acid nutrition, bone metabolism, and the Wnt/β-catenin signaling pathway

  • Life Science / Food sciences  / Lactoferrin, inflammation and infection defense, curcuminoids, adipocyte differentiation

  • Life Science / Cell biology  / Osteoblast differentiation, adipocyte differentiation, primary hepatocyte isolation and culture, nutritional environment

  • Life Science / Molecular biology  / Transcriptional regulation, post-transcriptional modification, translational control, post-translational modification, nutrient sensing, nutritional signaling

  • Life Science / Applied molecular and cellular biology  / Nutrient-mediated cellular regulation, ferroptosis, bone formation, metabolic homeostasis, cancer control

Research Interests

  • Lipoprotein receptor

  • Lipoprotein metabolism

  • Lifestyle-related diseases

  • Glucose metabolism

  • Osteoblast differentiation

  • Adipocyte differentiation

  • Ferroptosis

Research subject summary

  • 1.Elucidating the Molecular Basis of Nutrient-Our research investigates how nutrients—including amino acids, carbohydrates, lipids, vitamins, and minerals—regulate cellular differentiation and metabolic homeostasis through translational control and intracellular signaling. In particular, we focus on how branched-chain amino acid (BCAA) deficiency triggers translational stress responses and modulates the Wnt/β-catenin pathway, aiming to elucidate the molecular mechanisms by which cells sense and adapt to nutritional cues.

  • 2.Analyzing the Mechanisms of Metabolic Regulation by Food-Derived Bioactive Compounds
    We are investigating how food-derived bioactive compounds, such as lactoferrin from milk and curcumin from turmeric, modulate lipid metabolism, inflammation, and ferroptosis sensitivity at the molecular level. By elucidating how these compounds affect oxidative stress responses and lipid homeostasis, we aim to establish a scientific basis for non-pharmacological, nutrition-based interventions against obesity and dyslipidemia.

  • 3.Integrating Nutrient Response Networks for Molecular Nutrition-Based Applications
    We integrate molecular biology and nutritional approaches to construct a comprehensive model of the “nutritional response network,” which describes how nutrients and food-derived compounds interact with cellular molecules. By dynamically analyzing the effects of these factors on gene transcription, post-transcriptional modification, translation, and translational control, we aim to elucidate the molecular principles underlying nutrition-dependent regulation of cellular functions, ultimately establishing a foundation for diet-based strategies to promote health and longevity.

Research Career

  • Quantitative Visualization of Nutrient-Perturbation–Induced Molecular Dynamics

    Nutritional Perturbation Response、Molecular Dynamics、Visualization & Temporal Analysis 

    2025.10 - Now 

  • Branched-chain amino acid deficiency, translational control, bone formation, Wnt signaling, GCN2 pathway, ATF4, molecular nutrition

    Branched-chain amino acid deficiency, translational control, bone formation, Wnt signaling, molecular nutrition  International Joint Research

    2025.04 - Now 

  • Elucidation of Hepatic Mechanisms Responsible for FGF21 Resistance and Nutrient Stress Adaptation

    FGF21 resistance, nutrient-responsive hormone, hepatic metabolism, energy homeostasis  Joint Research in Organization

    2024.04 - Now 

  • Integrated Analysis of Ferroptosis and Nutrient Sensing Mechanisms

    Ferroptosis, nutrient sensing, lipid peroxidation, GPx4  Joint Research in Organization

    2023.04 - Now 

  • Metabolic Alterations in Glucose and Lipid Pathways in an Animal Model of Postmenopausal Estrogen Deficiency

    Postmenopausal model, estrogen deficiency, glucose metabolism, lipid metabolism, metabolic syndrome  Joint Research in Japan

    2022.04 - Now 

  • Elucidation of the Mechanisms by Which Vitamin E Suppresses the Onset of Metabolic Syndrome

    Metabolic syndrome, vitamin E, lipid peroxidation, insulin resistance, antioxidant activity  Joint Research in Japan

    2021.04 - Now 

  • Elucidation of the Molecular Mechanisms by Which Bisphenol A Regulates Bladder Cell Responses

    Bisphenol A, bladder cells, apoptosis, MAPK pathway, cell cycle  International Joint Research

    2021.04 - Now 

  • Elucidation of the Mechanisms by Which Curcuminoids Suppress Adipocyte Differentiation

    Curcuminoids, adipocyte differentiation, transcriptional regulation, oxidative stress, anti-obesity effect  Joint Research in Organization

    2020.04 - Now 

  • Molecular Mechanisms by Which Branched-Chain Amino Acid Deficiency Suppresses Wnt3a-Induced Osteoblast Differentiation

    Branched-chain amino acid deficiency, Wnt3a, osteoblast differentiation, translational control  International Joint Research

    2019.04 - Now 

  • Presenilin enhancer-2 (PSENEN), a component of the gamma-secretase complex, is involved in adipocyte differentiation

    PSENEN, gamma-secretase, adipocyte differentiation, Notch signaling, cell differentiation  International Joint Research

    2005.04 - Now 

  • Molecular mechanisms underlying obesity and abnormalities of glucose and lipid metabolism in the metabolic syndrome model OLETF rats

    Metabolic syndrome, OLETF rats, Obesity, Lipid metabolism, Insulin resistance 

    2003.04 - Now 

  • Purification and characterization of lactoferrin-binding protein

    Lactoferrin, IgGFCrBP, Intestine  Individual

    2001.04 - Now 

  • Apolipoprotein E Recepter 2 and Cholesterol metabolism in Brain

    Lipoprotein Receptor, ApoER2, cholesterol metabolism in brain  Joint Research in Japan

    1998.04 - Now 

  • Role of Lipoprotein Receptors in Lipoprotein Metabolism

    Lipoprotein, Lipoprotein Receptor, Hypercholesterolemia  Joint Research in Japan

    1994.04 - Now 

Professional Memberships

  • THE JAPANESE BIOCHEMICAL SOCIETY

      Domestic

  • 日本分子生物学会

      Domestic

  • 日本生理人類学会

      Domestic

Job Career (off-campus)

  • 東北大学・特別研究員   -

    1998 - 1999

Education

  • Tohoku University   Doctor's Course   Graduated/Completed

    - 1999

Papers

  • Purification and characterization of an IgG Fc gamma binding protein from the mouse intestine that interacts with lactoferrin Reviewed

    DongHo Kim, Ryoko Okamoto, Reiko Kananiwa, Kazuo Ikeda, Shigeru Saeki

    The Journal of Biochemistry   2025.11

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    Authorship:Lead author, Corresponding author   International / domestic magazine:International journal  

    DOI: https://doi.org/10.1093/jb/mvaf064

  • Altered expression of mRNA for the low-density lipoprotein receptor (LDLR) in injured motor neurons of rodent Reviewed

    Hama Isuzu, Kiryu-Seo Sumiko, Konishi Hiroyuki, Kim Dong-Ho, Saeki Shigeru, Kiyama Hiroshi

    NEUROSCIENCE RESEARCH   71   E339 - E340   2011( ISSN:0168-0102

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.neures.2011.07.1489

  • Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer's Disease Patients Reviewed

    Hosoda Akemi, Inoue Takashi, Mao Chang C., Jeong Young-Hee, Yamagishi Azumi, Ye Mingjuan, Yamamoto Tokuo, Kim Dong-Ho, Saeki Shigeru

    Japan Society for Bioscience, Biotechnology, and Agrochemistry BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   74 ( 3 )   677 - 679   2010.03( ISSN:0916-8451

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    Publishing type:Research paper (scientific journal)  

    Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

    DOI: 10.1271/bbb.90857

    CiNii Research

  • The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway Reviewed

    Jeong Young-Hee, Sekiya Manami, Hirata Michiko, Ye Mingjuan, Yamagishi Azumi, Lee Sang-Mi, Kang Man-Jong, Hosoda Akemi, Fukumura Tomoe, Kim Dong-Ho, Saeki Shigeru

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   392 ( 4 )   495 - 499   2010.02( ISSN:0006-291X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2010.01.049

  • Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family Reviewed

    Jeong Young-Hee, Ishikawa Kayoko, Someya Yoshimi, Hosoda Akemi, Yoshimi Tomohiko, Yokoyama Chikako, Kiryu-Seo Sumiko, Kang Man-Jong, Tchibana Taro, Kiyama Hiroshi, Fukumura Tomoe, Kim Dong-Ho, Saeki Shigeru

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   391 ( 1 )   1110 - 1115   2010.01( ISSN:0006-291X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2009.12.033

  • Presenilin enhancer-2 (PSENEN), a component of the gamma-secretase complex, is involved in adipocyte differentiation Reviewed

    Lee S. M., Jeong Y. H., Kim H. M., Park H. Y., Yoon D., Kim D. H., Saeki S., Moon S. J., Kang M. J.

    DOMESTIC ANIMAL ENDOCRINOLOGY   37 ( 3 )   170 - 180   2009.10( ISSN:0739-7240

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.domaniend.2009.05.003

  • 2-16 Mammalian Circadian Clock and Metabolic Syndrome(Proceedings of the 57th Meeting of Japan Society of Physiological Anthropology) : Reviewed

    SAEKI Shigeru, KIM Dong-Ho, KIM Cheol-Min, IWAMOTO Kyosuke, OGINO Tomoe, SEKIYA Manami, HIRATA Michiko, YAMAGISHI Azumi, HOSODA Akemi

    Japan Society of Physiological Anthropology Journal of physiological anthropology   27 ( 2 )   115 - 116   2008

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    Publishing type:Research paper (scientific journal)  

    CiNii Research

  • PD1-3 Association between Polymorphisms within the Apolipoprotein E Receptor 2 Gene and Sporadic Alzheimer's Disease in a Japanese Population(Proceedings of The 8th International Congress of Physiological Anthropology) : Reviewed

    SAEKI Shigeru, HOSODA Akemi, SOMEYA Yoshimi, SEKIYA Manami, YAMAGISHI Azumi, JEONG Young Hee, OGINO Tomoe, KIM Dong-Ho, SONE Yoshiaki

    Japan Society of Physiological Anthropology Journal of physiological anthropology   26 ( 2 )   312 - 313   2007

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    Publishing type:Research paper (scientific journal)  

    CiNii Research

  • 1-2 Diurnal Rhythm of the Lipid Metabolism in Rats(Proceedings of the 55th Meeting of Japan Society of Physiological Anthropology) : Reviewed

    SAEKI Shigeru, SOMEYA Yoshimi, YAMAGISHI Azumi, KIM Cheol-Min, Hosoda Akemi, OGINO Tomoe, KIM Dong-Ho, SONE Yoshiaki

    Japan Society of Physiological Anthropology Journal of physiological anthropology   25 ( 6 )   384 - 385   2006

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    Publishing type:Research paper (scientific journal)  

    CiNii Research

  • Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis Reviewed

    Nakatani K, Okuyama H, Shimahara Y, Saeki S, Kim DH, Nakajima Y, Seki S, Kawada N, Yoshizato K

    LABORATORY INVESTIGATION   84 ( 1 )   91 - 101   2004.01( ISSN:0023-6837

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/labinvest.3700013

  • Significant roles of lipid and lipoprotein metabolism in the life-style related diseases Reviewed

    SAEKI Shigeru, KIM Dong-Ho

    Japan Society for Bioscience, Biotechnology, and Agrochemistry, Nippon Nōgeikagaku Kaishi   77 ( 11 )   1120 - 1123   2003.11( ISSN:00021407

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/nogeikagaku1924.77.1120

    CiNii Research

  • Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E Reviewed

    Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 13 )   11331 - 11336   2003.03( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1074/jbc.M211987200

    PubMed

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion Reviewed

    Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   100 ( 1 )   229 - 234   2003.01( ISSN:0027-8424

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1073/pnas.0133792100

    PubMed

  • Significant roles of lipid and lipoprotein metabolism in the life-style related diseases

    SAEKI Shigeru, KIM Dong-Ho

    Nippon Nōgeikagaku Kaishi   77 ( 11 )   1120 - 1123   2003( ISSN:00021407 ( eISSN:18836844

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1271/nogeikagaku1924.77.1120

    CiNii Research

  • Seven novel sequence variants in the human low density lipoprotein receptor related protein 5 (LRP5) gene. Reviewed

    Okubo M, Horinishi A, Kim DH, Yamamoto TT, Murase T

    Human mutation   19 ( 2 )   186   2002.02( ISSN:1059-7794

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/humu.9012

    PubMed

  • Virus-mediated transduction of apolipoprotein E (ApoE)-Sendai develops lipoprotein glomerulopathy in ApoE-deficient mice Reviewed

    Ishigaki Y, Oikawa S, Suzuki T, Usui S, Magoori K, Kim DH, Suzuki H, Sasaki J, Sasano H, Okazaki M, Toyota T, Saito T, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   275 ( 40 )   31269 - 31273   2000.10( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

  • Role of Apolipoprotein E Receptors in Lipoprotein Metabolism.

    Lipoprotein Metabolism and Atherogenesis, Springer-Verlag   18   104 - 107   2000( ISBN:ISBN4-431-70261-X

  • A new low density lipoprotein receptor belated protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E Reviewed

    Kim DH, Inagaki Y, Suzuki T, Ioka RX, Yoshioka SZ, Magoori K, Kang MJ, Cho Y, Nakano AZ, Liu Q, Fujino T, Suzuki H, Sasano H, Yamamoto TT

    JOURNAL OF BIOCHEMISTRY   124 ( 6 )   1072 - 1076   1998.12( ISSN:0021-924X

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    Publishing type:Research paper (scientific journal)  

  • A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart Reviewed

    Tomita Y, Kim DH, Magoori K, Fujino T, Yamamoto TT

    JOURNAL OF BIOCHEMISTRY   124 ( 4 )   784 - 789   1998.10( ISSN:0021-924X

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    Publishing type:Research paper (scientific journal)  

  • Evolution of the apolipoprotein E receptor 2 gene by exon loss Reviewed

    Kim HJ, Kim DH, Magoori K, Saeki S, Yamamoto TT

    JOURNAL OF BIOCHEMISTRY   124 ( 2 )   451 - 456   1998.08( ISSN:0021-924X

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    Publishing type:Research paper (scientific journal)  

  • cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13.2 Reviewed

    Ishii H, Kim DH, Fujita T, Endo Y, Saeki S, Yamamoto TT

    GENOMICS   51 ( 1 )   132 - 135   1998.07( ISSN:0888-7543

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    Publishing type:Research paper (scientific journal)  

  • Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene Reviewed

    Kim DH, Magoori K, Inoue TR, Mao CC, Kim HJ, Suzuki H, Fujita T, Endo Y, Saeki S, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   272 ( 13 )   8498 - 8504   1997.03( ISSN:0021-9258

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  • アポEレセプター2遺伝子の構造と機能.

    金 東浩, 山本徳男

    代謝異常治療研究基金研究業績集   24   18 - 19   1997( ISSN:ISSN0388-5224

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    Publishing type:Research paper (scientific journal)  

  • Molecular Characterization of splicing variants of ApoE receptor 2

    ATHEROSCLEROSIS   134 ( 42737 )   358   1997

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    Publishing type:Research paper (scientific journal)  

  • Human apolipoprotein E receptor 2 - A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain Reviewed

    Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T

    JOURNAL OF BIOLOGICAL CHEMISTRY   271 ( 14 )   8373 - 8380   1996.04( ISSN:0021-9258

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    Publishing type:Research paper (scientific journal)  

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Books and Other Publications

  • 食べ物と健康,食品と衛生 食品学各論 第4版

    金 東浩( Role: Contributor ,  6. 発酵食品(微生物利用食品))

    講談社  2021.04  ( ISBN:9784065224663

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    Total pages:192   Responsible for pages:12   Book type:Textbook, survey, introduction

  • 非栄養素の分子栄養学

    芦田 均, 薩 秀夫, 中野 長久, 日本栄養食糧学会( Role: Joint author)

    建帛社  2017.05  ( ISBN:9784767961897

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    Book type:Scholarly book

    CiNii Research

  • 분자영양학

    도영술, 유리나, 박건영

    라이프사이언스  2010.03 

  • 分子栄養学

    金 東浩(9章 肥満の分子メカニズム)

    化学同人  2005.11 

  • 食Up to Date;食と健康,食と安全,食と環境,松田覚編

    金 東浩(コレステロール代謝と動脈硬化症)

    金芳堂  2005.01 

  • Role of Apolipoprotein E Receptors in Lipoprotein Metabolism

    KIM Dong-ho( Role: Sole author)

    Springer-Verlag  2000.09  ( ISBN:978-4-431-68424-4

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    Book type:Scholarly book

    DOI: https://doi.org/10.1007/978-4-431-68424-4_23

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Presentations

  • 高脂肪食の長期摂取がメタボリック症候群モデルラットのビタミンE代謝に与える影響 Domestic conference

    三澤莉帆,宇佐美夕夏、金 東浩,佐伯茂,阪野朋子,小林美里、池田彩子

    農芸化学会2025年度大会  2025.03 

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    Venue:札幌・札幌コンベンションセンター  

  • メタボリック症候群モデルラットのビタミンE代謝に与える高脂肪食の影響 Domestic conference

    宇佐美夕夏,三澤莉帆,金東浩,佐伯茂,阪野朋子,小林美里,池田彩子

    第34回ビタミンE研究会  2025.01 

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    Venue:名古屋・ウインクあいち  

  • 乳がん細胞のフェロトーシスに伴うApoER2転写産物の発現変動 Domestic conference

    綾部 日南子,荒木 涼菜,佐伯 茂,金 東浩

    BioMedical Forum 2025  2024.12 

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    Venue:大阪公立大学  

  • 3T3-L1細胞の脂肪細胞分化に対するクルクミノイド類の影響 Domestic conference

    上田 祐未、荒木 涼菜、綾部 日南子、増田 俊哉、佐伯 茂、金 東浩

    第63回日本栄養・食糧学会近畿支部大会  2024.10 

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    Venue:京都・京都府立大学  

  • ビタミンE代謝に対する性ホルモンの影響 Domestic conference

    宇佐美夕夏、三澤莉帆、金 東浩、佐伯 茂、阪野朋子、小林美里、 池田彩子、藤原葉子

    第63回日本栄養・食糧学会近畿支部大会  2024.10 

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    Venue:京都・京都府立大学  

  • フェロトーシスに伴うApoER2バリアントの発現変動 Domestic conference

    綾部 日南子、佐伯 茂、金 東浩

    第63回日本栄養・食糧学会近畿支部大会  2024.10 

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    Venue:京都・京都府立大学  

  • バリン欠乏センシングによるWnt/β-cateninシグナル伝達経路の制御 Domestic conference

    助田 陽花、小嶋 睦希、米田 菜月、水野 晴香、金 炫秀、佐伯 茂、 金 東浩

    第63回日本栄養・食糧学会近畿支部大会  2024.10 

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    Venue:京都・京都府立大学  

  • 遺伝的メタボリック症候群モデル動物におけるビタミンE代謝動態 Domestic conference

    池田彩子、田路莉子、三澤莉帆、小林美里、阪野朋子、金 東浩、佐伯 茂

    農芸化学会2024年度大会  2024.03 

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    Venue:東京大学  

  • 飼料組成に対するα-トコフェロール代謝応答の相違 Domestic conference

    田路 莉子, 金 東浩, 佐伯 茂, 小林 美里, 阪野 朋子, 池田 彩子

    第33回ビタミンE研究会  2024.01  東京慈恵会医科大学

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    Presentation type:Oral presentation (general)  

  • がん細胞のフェロトーシスにおけるリポタンパク質受容体ファミリー遺伝子の発現 Domestic conference

    綾部日南子,助田陽花,田路莉子,米田菜月,三澤莉帆,佐伯 茂,金 東浩

    BioMedical Forum 2024  2023.12 

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    Venue:大阪公立大学  

  • Increased Vitamin E Requirement in a Rat Model of Spontaneous Metabolic Syndrome International conference

    Riho MISAWA, Riko TOJI, DongHo KIM, Shigeru SAEKI, Misato KOBAYASHI, Tomoko BANNO, Saiko IKEDA

    2023 International Conference of KSMCB  2023.11 

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    Venue:Korea  

  • Effects of Lipoprotein Receptors on Function of Selenoprotein P in Glucose Metabolism International conference

    Natsuki YONEDA, Aki FUJIWARA, Haruka SUKEDA, Riko TOJI, Shigeru SAEKI, DongHo KIM

    2023 International Conference of KSMCB  2023.11 

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    Venue:Korea  

  • Fat Accumulation Mechanisms in OLETF Rats, a Model of Spontaneous Metabolic Syndrome International conference

    Riko TOJI, Ryotaro SHIGA, Riho MISAWA, ManJong KANG, Saiko IKEDA, Misato KOBAYASHI, Shigeru SAEKI, DongHo KIM

    2023 International Conference of KSMCB  2023.11 

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    Venue:Korea  

  • Effects of Branched-Chain Amino Acids on the Wnt/-catenin Signaling Pathway in ST2 Cells, Mesenchymal Stem Cells Derived from Mouse Bone Marrow International conference

    Haruka SUKEDA, Haruka MIZUNO, Natsuki YONEDA, Hinako AYABE, SangWoon LEE, WooJin KIM, HyunSoo KIM, Daiki HABU, Shigeru SAEKI, DongHo KIM

    2023 International Conference of KSMCB  2023.11 

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    Venue:Korea  

  • Inhibitory Effect of Curcuminoids on Adipocyte Differentiation of 3T3-L1 Cells International conference

    DongHo KIM, Yumi UEDA, Haruka SUKEDA, Hinako AYABE, ManJong KANG, Toshiya MASUDA, Shigeru SAEKI

    2023 International Conference of KSMCB  2023.11 

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    Venue:Korea  

  • メタボリック症候群モデルラットにおける腸内細菌叢の変動 Domestic conference

    三澤 莉帆、田路 莉子、森田 真衣、佐伯 茂、金 東浩

    第77 回日本栄養・食糧学会大会  2023.05 

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    Venue:札幌コンベンションセンター  

  • 遺伝的メタボリック症候群モデルラットのビタミンE体内利⽤の亢進 Domestic conference

    池⽥彩⼦,⽥路 莉⼦,⾦ 東浩,⼩林 美⾥,阪野 朋⼦,佐伯 茂

    第32回ビタミンE研究会  2023.01 

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    Venue:京都府⽴京都学  

  • Studies on the Vitamin E metabolism in Otsuka-Long-Evans-Tokushima-Fatty rats International conference

    Saiko IKEDA, Riko TOJI, Ryotaro SHIGA, Yuka TANAKA, DongHo KIM, Misato KOBAYASHI, Tomoko BANNO, Shigeru SAEKI

    22nd IUNS-ICN International Congress of Nutrition  2022.12 

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    Venue:Tokyo, Japan  

  • OLETFラットの脂肪蓄積機構の解析 Domestic conference

    田路 莉子、志賀 遼太朗、佐伯 茂、金 東浩

    第61回日本栄養・食糧学会近畿支部会  2022.10 

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    Venue:滋賀県立大学  

  • 間葉系幹細胞のWnt/β-cateninシグナル伝達経路に対する分岐鎖アミノ酸の影響 Domestic conference

    助田陽花、水野晴香、藤原有紀、佐伯 茂、金 東浩

    第61回日本栄養・食糧学会近畿支部会  2022.10 

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    Venue:滋賀県立大学  

  • 糖質代謝を担うセレノプロテインPに対するリポタンパク質受容体遺伝子の影響 Domestic conference

    藤原有紀、助田陽花、佐伯 茂、金 東浩

    第61回日本栄養・食糧学会近畿支部会  2022.10 

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    Venue:滋賀県立大学  

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Collaborative research (seeds) keywords

  • 分岐鎖アミノ酸感知

  • リポタンパク質受容体

Outline of collaborative research (seeds)

  • リポタンパク質代謝に関する分子栄養学的研究

    2000.4-2005.3

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    Request for collaborative research:Universities etc. Research institutes

    Type of research exchange:Technical consultation, Joint research, 共同研究, 受託研究, 各種相談, 講演, 調査

    Application fields / methods etc:現在まで明らかになっているリポタンパク質レセプターに関する知識を用いてリポタンパク質代謝に関する研究が可能になる。

    本研究はLDLレセプターを初めとするリポタンパク質レセプターとリポタンパク質代謝に関する分子栄養学的研究である。

  • 分岐鎖アミノ酸感知を介した骨形成・代謝制御機構の解明と栄養介入による健康長寿支援技術の開発

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    Request for collaborative research:Universities etc. Research institutes

    Type of research exchange:Technical consultation, Contract research, Joint research, Lecture

    齢や栄養バランスの乱れにより、骨密度低下や筋量減少、代謝異常が進行することが知られています。
    近年の研究から、バリン(Val)やイソロイシン(Ile)などの分岐鎖アミノ酸(BCAA)が、単なるエネルギー源ではなく、細胞内で「栄養シグナル」として遺伝子発現や分化を制御していることが明らかになりつつあります。
    本研究では、BCAA欠乏時に活性化する翻訳ストレス応答やWnt/β-カテニン経路、mTOR/GCN2経路の変化を統合的に解析し、栄養素が骨形成や代謝恒常性をどのように制御するかの分子基盤を解明します。

Grant-in-Aid for Scientific Research

  • リポタンパク質受容体とセレノプロテインPを標的とした2型糖尿病抑制の食品成分探索

    Grant-in-Aid for Scientific Research(C)  2021.04

Charge of on-campus class subject

  • 栄養生理学実習

    2025   Weekly class   Undergraduate

  • 微生物学

    2025   Weekly class   Undergraduate

  • 基礎細胞生物学

    2025   Weekly class   Undergraduate

  • 食栄養学概論

    2025   Weekly class   Undergraduate

  • 食栄養学研究基礎演習1

    2025   Intensive lecture   Graduate school

  • 生体機能学特論演習A

    2025   Intensive lecture   Graduate school

  • 初年次ゼミナール

    2025   Weekly class   Undergraduate

  • 健康へのアプローチ

    2025   Weekly class   Undergraduate

  • 食栄養学特別講義A

    2025   Intensive lecture   Graduate school

  • 前期特別研究

    2025   Intensive lecture   Graduate school

  • 食栄養学研究基礎演習2

    2025   Intensive lecture   Graduate school

  • 生体機能学特論演習B

    2025   Intensive lecture   Graduate school

  • 生体機能学特論

    2025   Weekly class   Graduate school

  • 卒業論文

    2025   Intensive lecture   Undergraduate

  • 栄養学研究基礎演習

    2025   Intensive lecture   Undergraduate

  • 分子生物学実験

    2025   Weekly class   Undergraduate

  • 分子生物学実験

    2025   Weekly class   Undergraduate

  • 栄養生理学実習

    2024   Weekly class   Undergraduate

  • 基礎細胞生物学

    2024   Weekly class   Undergraduate

  • 食栄養学概論

    2024   Weekly class   Undergraduate

  • 食栄養学研究基礎演習1

    2024   Intensive lecture   Graduate school

  • 生体機能学特論演習A

    2024   Intensive lecture   Graduate school

  • 健康へのアプローチ

    2024   Weekly class   Graduate school

  • 分子生物学実験

    2024   Weekly class   Undergraduate

  • 食栄養学研究基礎演習2

    2024   Intensive lecture   Graduate school

  • 生体機能学特論演習B

    2024   Intensive lecture   Graduate school

  • 生体機能学特論

    2024   Weekly class   Graduate school

  • 前期特別研究

    2024   Intensive lecture   Graduate school

  • 生体機能学特論演習

    2024   Intensive lecture   Graduate school

  • 生体機能学特論

    2024   Weekly class   Graduate school

  • 基礎演習

    2024   Intensive lecture   Undergraduate

  • 卒業論文

    2024   Intensive lecture   Undergraduate

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International exchange activities

  • 韓国東亜大学との共同研究

    Field category :Research

    Country name :韓国   2024.10 - Now

  • 韓国忠南大学との共同研究

    Field category :Research

    Country name :韓国   2018.04 - Now

  • 韓国中央大学との共同研究

    Field category :Research

    Country name :韓国   2010.04 - Now

Other

  • Job Career

    2000

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    Osaka City University