2022/07/13 更新

写真a

キム ドンホ
金 東浩
KIM DongHo
担当
大学院生活科学研究科 生活科学専攻 准教授
生活科学部 食栄養学科
職名
准教授
所属
生活科学研究院

担当・職階

  • 大学院生活科学研究科 生活科学専攻 

    准教授  2022年04月 - 継続中

  • 生活科学部 食栄養学科 

    准教授  2022年04月 - 継続中

取得学位

  • 博士(農学) ( 東北大学 )

研究分野

  • ライフサイエンス / 分子生物学  / リポ蛋白代謝

  • ライフサイエンス / 食品科学

  • ライフサイエンス / 細胞生物学

研究キーワード

  • リポタンパク質受容体

  • Wntシグナル伝達

  • メタボリック症候群

  • リポタンパク質代謝

研究概要

  • 栄養生理学は食物(栄養素、非栄養素)が消化吸収され、体内で代謝される過程で、身体はどのような仕組みで対応しており、また身体はどのような影響を受けるものかを調べる学問で、基礎研究と臨床の両面で生物学・医学の大切な領域である。21世紀に向けた新しい栄養生理学の最前線を切り開くためには、遺伝子レベルでの解析が不可欠である。遺伝子レベルの研究としては、遺伝子の塩基配列を決定するだけでなく、生体内における遺伝子機能を解明するのことが生物学・医学の最も重要な課題となっている。本研究は、分子生物学及び栄養学的な方法を用いて動脈硬化や高脂血症の病因を明らかにする事である。

研究歴

  • リポタンパク質代謝に関する分子栄養学的研究

    リポタンパク質、リポタンパク質受容体、高脂血症  個人研究

    1900年04月 

  • 脳のコレステロール代謝とアポEレセプター2

    リポ蛋白レセプター  機関内共同研究

    1900年04月 

所属学協会

  • 日本生化学会

      国内

  • 日本生理人類学会

      国内

  • 日本農芸化学会

      国内

  • 日本栄養・食糧学会

      国内

  • 日本分子生物学会

      国内

職務経歴(学外)

  • 東北大学・特別研究員   -

    1998年 - 1999年

学歴

  • 東北大学   農学研究科   農芸化学科 遺伝子研究法   博士課程   卒業・修了

    - 1999年

  • 檀国大学校   自然科学部   微生物学科    

    - 1991年

論文

  • Severe hypercholesterolemia, impaired fat tolerance and advanced atherosclerosis in mice lacking both LDL receptor-related protein 5 (LRP5) and apolipoprotein E

    Magoori K, Kang MJ, Iwasaki MI, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei Y

    Journal of Biological Chemistry   278 ( 13 )   11331 - 11336   2003年

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    掲載種別:研究論文(学術雑誌)  

  • Altered expression of mRNA for the low-density lipoprotein receptor (LDLR) in injured motor neurons of rodent 査読

    Hama Isuzu, Kiryu-Seo Sumiko, Konishi Hiroyuki, Kim Dong-Ho, Saeki Shigeru, Kiyama Hiroshi

    NEUROSCIENCE RESEARCH   71   E339 - E340   2011年( ISSN:0168-0102

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.neures.2011.07.1489

  • Polymorphisms in the Human Apolipoprotein E Receptor 2 Gene in Japanese Sporadic Alzheimer's Disease Patients 査読

    Hosoda Akemi, Inoue Takashi, Mao Chang C., Jeong Young-Hee, Yamagishi Azumi, Ye Mingjuan, Yamamoto Tokuo, Kim Dong-Ho, Saeki Shigeru

    Japan Society for Bioscience, Biotechnology, and Agrochemistry BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   74 ( 3 )   677 - 679   2010年03月( ISSN:0916-8451

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    掲載種別:研究論文(学術雑誌)  

    Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.

    DOI: 10.1271/bbb.90857

    CiNii Article

  • The low-density lipoprotein receptor-related protein 10 is a negative regulator of the canonical Wnt/beta-catenin signaling pathway 査読

    Jeong Young-Hee, Sekiya Manami, Hirata Michiko, Ye Mingjuan, Yamagishi Azumi, Lee Sang-Mi, Kang Man-Jong, Hosoda Akemi, Fukumura Tomoe, Kim Dong-Ho, Saeki Shigeru

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   392 ( 4 )   495 - 499   2010年02月( ISSN:0006-291X

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbrc.2010.01.049

  • Molecular characterization and expression of the low-density lipoprotein receptor-related protein-10, a new member of the LDLR gene family 査読

    Jeong Young-Hee, Ishikawa Kayoko, Someya Yoshimi, Hosoda Akemi, Yoshimi Tomohiko, Yokoyama Chikako, Kiryu-Seo Sumiko, Kang Man-Jong, Tchibana Taro, Kiyama Hiroshi, Fukumura Tomoe, Kim Dong-Ho, Saeki Shigeru

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   391 ( 1 )   1110 - 1115   2010年01月( ISSN:0006-291X

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.bbrc.2009.12.033

  • Polymorphisms in the human apolipoprotein E receptor 2 gene in Japanese sporadic Alzheimer's disease patients. 査読

    Hosoda A, Inoue T, Mao CC, Jeong YH, Yamagishi A, Ye M, Yamamoto T, Kim DH, Saeki S

    Bioscience, biotechnology, and biochemistry   74 ( 3 )   677 - 9   2010年( ISSN:0916-8451

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    掲載種別:研究論文(学術雑誌)  

    PubMed

  • Presenilin enhancer-2 (PSENEN), a component of the gamma-secretase complex, is involved in adipocyte differentiation 査読

    Lee S. M., Jeong Y. H., Kim H. M., Park H. Y., Yoon D., Kim D. H., Saeki S., Moon S. J., Kang M. J.

    DOMESTIC ANIMAL ENDOCRINOLOGY   37 ( 3 )   170 - 180   2009年10月( ISSN:0739-7240

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1016/j.domaniend.2009.05.003

  • 2-16 Mammalian Circadian Clock and Metabolic Syndrome(Proceedings of the 57th Meeting of Japan Society of Physiological Anthropology) : 査読

    SAEKI Shigeru, KIM Dong-Ho, KIM Cheol-Min, IWAMOTO Kyosuke, OGINO Tomoe, SEKIYA Manami, HIRATA Michiko, YAMAGISHI Azumi, HOSODA Akemi

    Japan Society of Physiological Anthropology Journal of physiological anthropology   27 ( 2 )   115 - 116   2008年

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    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • PD1-3 Association between Polymorphisms within the Apolipoprotein E Receptor 2 Gene and Sporadic Alzheimer's Disease in a Japanese Population(Proceedings of The 8th International Congress of Physiological Anthropology) : 査読

    SAEKI Shigeru, HOSODA Akemi, SOMEYA Yoshimi, SEKIYA Manami, YAMAGISHI Azumi, JEONG Young Hee, OGINO Tomoe, KIM Dong-Ho, SONE Yoshiaki

    Japan Society of Physiological Anthropology Journal of physiological anthropology   26 ( 2 )   312 - 313   2007年

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    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • Association between Polymorphisms within the Apolipoprotein E Receptor 2 Gene and Sporadic Alzheimer's Disease in a Japanese Population (Proceedings of the 54th Meeting of Japan Society of Physiological Anthropology) : 査読

    SAEKI Shigeru, KIM Dong-Ho, OGINO Tomoe, SONE Yoshiaki

    Japan Society of Physiological Anthropology Journal of physiological anthropology   25 ( 2 )   2006年

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    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • 1-2 Diurnal Rhythm of the Lipid Metabolism in Rats(Proceedings of the 55th Meeting of Japan Society of Physiological Anthropology) : 査読

    SAEKI Shigeru, SOMEYA Yoshimi, YAMAGISHI Azumi, KIM Cheol-Min, Hosoda Akemi, OGINO Tomoe, KIM Dong-Ho, SONE Yoshiaki

    Japan Society of Physiological Anthropology Journal of physiological anthropology   25 ( 6 )   384 - 385   2006年

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    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis 査読

    Nakatani K, Okuyama H, Shimahara Y, Saeki S, Kim DH, Nakajima Y, Seki S, Kawada N, Yoshizato K

    LABORATORY INVESTIGATION   84 ( 1 )   91 - 101   2004年01月( ISSN:0023-6837

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/labinvest.3700013

  • Cytoglobin/STAP, its unique localization in splanchnic fibroblast-like cells and function in organ fibrogenesis. 査読

    Nakatani K, Okuyama H, Shimahara Y, Saeki S, Kim DH, Nakajima Y, Seki S, Kawada N, Yoshizato K

    Laboratory investigation; a journal of technical methods and pathology   84 ( 1 )   91 - 101   2004年01月( ISSN:0023-6837

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1038/sj.labinvest.3700013

    PubMed

  • 脂質代謝と「食」と「栄養」のバイオサイエンス : 脂質代謝の分子機構 査読

    佐伯 茂, 金 東浩

    公益社団法人 日本農芸化学会 日本農藝化學會誌 = Journal of the Agricultural Chemical Society of Japan   77 ( 11 )   1120 - 1123   2003年11月( ISSN:00021407

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1271/nogeikagaku1924.77.1120

    CiNii Article

  • Severe hypercholesterolemia, impaired fat tolerance, and advanced atherosclerosis in mice lacking both low density lipoprotein receptor-related protein 5 and apolipoprotein E 査読

    Magoori K, Kang MJ, Ito MR, Kakuuchi H, Ioka RX, Kamataki A, Kim DH, Asaba H, Iwasaki S, Takei YA, Sasaki M, Usui S, Okazaki M, Takahashi S, Ono M, Nose M, Sakai J, Fujino T, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 13 )   11331 - 11336   2003年03月( ISSN:0021-9258

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1074/jbc.M211987200

    PubMed

  • Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1 査読

    Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sasano H, Takahashi S, Sakai J, Fujino T, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   278 ( 9 )   7344 - 7349   2003年02月( ISSN:0021-9258

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1074/jbc.M211932200

    PubMed

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion 査読

    Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M, Murase T, Kamataki A, Yamamoto J, Magoori K, Takahashi S, Miyamoto Y, Oishi H, Nose M, Okazaki M, Usui S, Imaizumi K, Yanagisawa M, Sakai J, Yamamoto TT

    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA   100 ( 1 )   229 - 234   2003年01月( ISSN:0027-8424

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1073/pnas.0133792100

    PubMed

  • Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

    Fujino T, Asaba H, Kang MJ, Ikeda Y, Sone H, Takada S, Kim DH, Ioka RX, Ono M, Tomoyori H, Okubo M,

    Proc Natl Acad Sci USA   100 ( 1 )   229 - 234   2003年

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    掲載種別:研究論文(学術雑誌)  

  • Expression cloning and characterization of a novel glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein, GPI-HBP1

    Ioka RX, Kang MJ, Kamiyama S, Kim DH, Magoori K, Kamataki A, Ito Y, Takei YA, Sasaki M, Suzuki T, Sa

    Journal of Biological Chemistry   278 ( 9 )   7344 - 7349   2003年

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

  • Seven novel sequence variants in the human low density lipoprotein receptor related protein 5 (LRP5) gene. 査読

    Okubo M, Horinishi A, Kim DH, Yamamoto TT, Murase T

    Human mutation   19 ( 2 )   186   2002年02月( ISSN:1059-7794

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    掲載種別:研究論文(学術雑誌)  

    DOI: 10.1002/humu.9012

    PubMed

  • Seven novel sequence variants in the human low density lipoprotein receptor related protein 5 (LRP5) gene

    Okubo M., Horinishi A., Kim D.-H., Yamamoto T.T., Murase T.

    Human Mutation   19 ( 2 )   186 - 188   2002年

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    掲載種別:研究論文(学術雑誌)  

  • Virus-mediated transduction of apolipoprotein E (ApoE)-Sendai develops lipoprotein glomerulopathy in ApoE-deficient mice 査読

    Ishigaki Y, Oikawa S, Suzuki T, Usui S, Magoori K, Kim DH, Suzuki H, Sasaki J, Sasano H, Okazaki M, Toyota T, Saito T, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   275 ( 40 )   31269 - 31273   2000年10月( ISSN:0021-9258

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    掲載種別:研究論文(学術雑誌)  

  • Role of Apolipoprotein E Receptors in Lipoprotein Metabolism.

    Yamamoto T.T., Inagaki Y., Ioka R.X.,. Yoshioka S.Z., Magoori K., et al.

    Lipoprotein Metabolism and Atherogenesis, Springer-Verlag   18   104 - 107   2000年( ISBN:ISBN4-431-70261-X

  • Virus Mediated Transduction of ApoE-Sendai Develops Lipoprotein Glomerulopathy in ApoE Deficient Mice

    Ishigaki Y., Oikawa S., Suzuki T., Usui S., Magoori K., Kim D.H., Sasaki J., Sasano K., Okazaki M.,

    Journal of Biological Chemistry   275   31269 - 31273   2000年( ISSN:ISSN0021-9258

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    掲載種別:研究論文(学術雑誌)  

  • A New Density Lipoprotein Receptor Related Protein,LRP5,Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E 査読

    Kim Dong-Ho, Inagaki Yousuke, Suzuki Takashi, IOKA Ryoichi X., YOSHIOKA Shiroh Z., MAGOORI Kenta, KANG Man-Jong, CHO Yuko, NAKANO Akira Z., LIU Qiong, FUJINO Takahiro, SUZUKI Hiroyuki, SASANO Hironobu, YAMAMOTO Tokyo T.

    Japanese Biochemical Society The journal of biochemistry   124 ( 6 )   1072 - 1076   1998年12月( ISSN:0021924X

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    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • A new low density lipoprotein receptor belated protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E 査読

    Kim DH, Inagaki Y, Suzuki T, Ioka RX, Yoshioka SZ, Magoori K, Kang MJ, Cho Y, Nakano AZ, Liu Q, Fujino T, Suzuki H, Sasano H, Yamamoto TT

    JOURNAL OF BIOCHEMISTRY   124 ( 6 )   1072 - 1076   1998年12月( ISSN:0021-924X

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    掲載種別:研究論文(学術雑誌)  

  • A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart 査読

    Tomita Yasuhiro, Kim Dong-Ho, Magoori Kenta, FUJINO Takahiro, YAMAMOTO Tokuo T.

    Japanese Biochemical Society The journal of biochemistry   124 ( 4 )   784 - 789   1998年10月( ISSN:0021924X

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • A novel low-density lipoprotein receptor-related protein with type II membrane protein-like structure is abundant in heart 査読

    Tomita Y, Kim DH, Magoori K, Fujino T, Yamamoto TT

    JOURNAL OF BIOCHEMISTRY   124 ( 4 )   784 - 789   1998年10月( ISSN:0021-924X

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

  • Evolution of the Apolipoprotein EReceptor 2 Gene Exon Loss 査読

    Kim Hyoun-Ju, Kim Dong-Ho, Magoori Kenta, SAEKI Shigeru, YAMAMOTO Tokuo

    Japanese Biochemical Society The journal of biochemistry   124 ( 2 )   451 - 456   1998年08月( ISSN:0021924X

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    掲載種別:研究論文(学術雑誌)  

    CiNii Article

  • Evolution of the apolipoprotein E receptor 2 gene by exon loss 査読

    Kim HJ, Kim DH, Magoori K, Saeki S, Yamamoto TT

    JOURNAL OF BIOCHEMISTRY   124 ( 2 )   451 - 456   1998年08月( ISSN:0021-924X

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    掲載種別:研究論文(学術雑誌)  

  • cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13.2 査読

    Ishii H, Kim DH, Fujita T, Endo Y, Saeki S, Yamamoto TT

    GENOMICS   51 ( 1 )   132 - 135   1998年07月( ISSN:0888-7543

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    掲載種別:研究論文(学術雑誌)  

  • Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss. 査読

    Kim Hyoun-Ju, Kim Dong-Ho, Magoori Kenta, Saeki Shigeru, Yamamoto Tokuo T.

    社団法人 日本生化学会 The Journal of Biochemistry   124 ( 2 )   451 - 456   1998年

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    掲載種別:研究論文(学術雑誌)  

    The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by “exon shuffling.” Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.

    CiNii Article

  • Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss. 査読

    Kim Hyoun-Ju, Kim Dong-Ho, Magoori Kenta, Saeki Shigeru, Yamamoto Tokuo T.

    The Japanese Biochemical Society The Journal of Biochemistry   124 ( 2 )   451 - 456   1998年( ISSN:0021-924X

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    The apolipoprotein E receptor 2 (apoER2) gene consists of a mosaic of exons, which may have been assembled by "exon shuffling." Analysis of apoER2 transcripts in several species reveals a lost repeat in the ligand-binding domain of primate apoER2. A pseudo-exon found in the primate apoER2 genes corresponds to the lost repeat but contains a crucial deletion that leads to a translational frameshift. The pseudo-exon sequence in primary transcripts of the human apoER2 gene is shown to be abolished by exon skipping due to two nucleotide substitutions at the 5'-splice donor adjacent to the pseudo-exon. These data suggest the occurrence of exon loss in the evolution of the primate apoER2 gene.

    CiNii Article

  • A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart. 査読

    Tomita Yasuhiro, Kim Dong-Ho, Magoori Kenta, Fujino Takahiro, Yamamoto Tokuo T.

    The Japanese Biochemical Society The Journal of Biochemistry   124 ( 4 )   784 - 789   1998年( ISSN:0021-924X

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    We report herein the identification of a novel member of the low-density lipoprotein receptor (LDLR) family termed LDLR-related protein 4 (LRP 4). Murine LRP 4 cDNA encodes a 1113-amino-acid type II membrane-like protein with eight ligand-binding repeats in two clusters. Southern blot analysis of genomic DNA from several different organisms suggests the presence of LRP 4 homologues in chicken lacking the gene encoding apolipoprotein E, which is recognized by the ligand-binding repeats of LDLR. LRP 4 transcripts were detected almost exclusively in heart in mouse and humans. Despite the presence of the ligand-binding repeats, COS cells transfected with LRP 4 did not show surface-binding of β-migrating very-low-density lipoprotein, suggesting that LRP 4 plays a role in a pathway other than lipoprotein metabolism.

    CiNii Article

  • A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart. 査読

    Tomita Yasuhiro, Kim Dong-Ho, Magoori Kenta, Fujino Takahiro, Yamamoto Tokuo T.

    社団法人 日本生化学会 The Journal of Biochemistry   124 ( 4 )   784 - 789   1998年

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    We report herein the identification of a novel member of the low-density lipoprotein receptor (LDLR) family termed LDLR-related protein 4 (LRP 4). Murine LRP 4 cDNA encodes a 1113-amino-acid type II membrane-like protein with eight ligand-binding repeats in two clusters. Southern blot analysis of genomic DNA from several different organisms suggests the presence of LRP 4 homologues in chicken lacking the gene encoding apolipoprotein E, which is recognized by the ligand-binding repeats of LDLR. LRP 4 transcripts were detected almost exclusively in heart in mouse and humans. Despite the presence of the ligand-binding repeats, COS cells transfected with LRP 4 did not show surface-binding of β-migrating very-low-density lipoprotein, suggesting that LRP 4 plays a role in a pathway other than lipoprotein metabolism.

    CiNii Article

  • A New Low Density Lipoprotein Receptor Related Protein, LRP5, Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E1. 査読

    Kim Dong-Ho, Inagaki Yousuke, Suzuki Takashi, Ioka Ryoichi X., Yoshioka Shiroh Z., Magoori Kenta, Kang Man-Jong, Cho Yuko, Nakano Akira Z., Liu Qiong, Fujino Takahiro, Suzuki Hiroyuki, Sasano Hironobu, Yamamoto Tokuo T.

    社団法人 日本生化学会 The Journal of Biochemistry   124 ( 6 )   1072 - 1076   1998年

     詳細を見る

    掲載種別:研究論文(学術雑誌)  

    The isolation and characterization of rabbit and human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes a 1, 616-amino acid type I membrane-like protein with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing human LRP5 exhibited increased binding of apolipoprotein E (apoE)-enriched &beta;-migrating very low density lipoprotein. Northern blotting and <i>in situ</i> hybridization revealed a high level of LRP5 expression in hepatocytes and the adrenal gland cortex. In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions.

    CiNii Article

  • A New Low Density Lipoprotein Receptor Related Protein, LRP5, Is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E1. 査読

    Kim Dong-Ho, Inagaki Yousuke, Suzuki Takashi, Ioka Ryoichi X., Yoshioka Shiroh Z., Magoori Kenta, Kang Man-Jong, Cho Yuko, Nakano Akira Z., Liu Qiong, Fujino Takahiro, Suzuki Hiroyuki, Sasano Hironobu, Yamamoto Tokuo T.

    The Japanese Biochemical Society The Journal of Biochemistry   124 ( 6 )   1072 - 1076   1998年( ISSN:0021-924X

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    掲載種別:研究論文(学術雑誌)  

    The isolation and characterization of rabbit and human cDNAs revealed a new low density lipoprotein receptor (LDLR)-related protein (LRP) designated as LRP5. Human LRP5 cDNA encodes a 1, 616-amino acid type I membrane-like protein with three ligand binding repeats in its extracellular region. LDLR-deficient cells transduced by recombinant adenovirus containing human LRP5 exhibited increased binding of apolipoprotein E (apoE)-enriched β-migrating very low density lipoprotein. Northern blotting and <i>in situ</i> hybridization revealed a high level of LRP5 expression in hepatocytes and the adrenal gland cortex. In LDLR-deficient Watanabe heritable hyperlipidemic rabbits, LRP5 mRNA was increased in the liver and accumulated in cholesterol-laden foam cells of atherosclerotic lesions.

    CiNii Article

  • Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss.

    -

    Journal of Biochemistry   124 ( 2 )   451 - 456   1998年( ISSN:ISSN 0021-924X

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    掲載種別:研究論文(学術雑誌)  

  • cDNA Cloning of a New Low-Density Lipoprotein Receptor-Related Protein and Mapping of Its Gene (LRP3) to Chromosome Bands 19q12-q13.2.

    Ishii H., Kim D.-H., Fujita T., Endo Y., Saeki S.,

    Genomics   51 ( 1 )   132 - 135   1998年( ISSN:ISSN: 0888-7543

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    掲載種別:研究論文(学術雑誌)  

  • A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart.

    Tomita Y., Kim D.-H., Magoori K., Fujino T., and Yamamoto T.T.

    Journal of Biochemistry   124 ( 4 )   784 - 789   1998年( ISSN:ISSN0021-924X

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    掲載種別:研究論文(学術雑誌)  

  • A New Low Density Lipoprotein Receptor Related Protein, LRP5, is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E.

    Kim D.-H., Inagaki Y., Suzuki T., Ioka R.X., Yoshioka S.Z., et al.

    Journal of Biochemistry   124 ( 6 )   1072 - 1076   1998年( ISSN:ISSN0021-924X

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    掲載種別:研究論文(学術雑誌)  

  • Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene 査読

    Kim DH, Magoori K, Inoue TR, Mao CC, Kim HJ, Suzuki H, Fujita T, Endo Y, Saeki S, Yamamoto TT

    JOURNAL OF BIOLOGICAL CHEMISTRY   272 ( 13 )   8498 - 8504   1997年03月( ISSN:0021-9258

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    掲載種別:研究論文(学術雑誌)  

  • Exon/Intron Organization, Chromosome Localization, Alternative Splicing, and Transcription Units of the Human Apolipoprotein E Receptor 2 Gene.

    -

    Journal of Biological Chemistry   272 ( 13 )   8498 - 8504   1997年( ISSN:ISSN0021-9258

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    掲載種別:研究論文(学術雑誌)  

  • アポEレセプター2遺伝子の構造と機能.

    金 東浩, 山本徳男

    代謝異常治療研究基金研究業績集   24   18 - 19   1997年( ISSN:ISSN0388-5224

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    掲載種別:研究論文(学術雑誌)  

  • Molecular Characterization of splicing variants of ApoE receptor 2

    Kim D.-H., Kim H.-J., Magoori K., Yamamoto T.T.

    ATHEROSCLEROSIS   134 ( 42737 )   358   1997年

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    掲載種別:研究論文(学術雑誌)  

  • Human apolipoprotein E receptor 2 - A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain 査読

    Kim DH, Iijima H, Goto K, Sakai J, Ishii H, Kim HJ, Suzuki H, Kondo H, Saeki S, Yamamoto T

    JOURNAL OF BIOLOGICAL CHEMISTRY   271 ( 14 )   8373 - 8380   1996年04月( ISSN:0021-9258

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    掲載種別:研究論文(学術雑誌)  

  • Human Apolipoprotein E Receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.

    Kim D.-H., Iijima H., Goto K., Sakai J., Ishii H.,

    Journal of Biological Chemistry   271 ( 14 )   8373 - 8380   1996年( ISSN:ISSN0021-9258

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    掲載種別:研究論文(学術雑誌)  

▼全件表示

書籍等出版物

  • 非栄養素の分子栄養学

    芦田 均, 薩 秀夫, 中野 長久, 日本栄養食糧学会( 担当: 共著)

    建帛社  2017年  ( ISBN:9784767961897

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    著書種別:学術書  

    CiNii Books

  • Role of Apolipoprotein E Receptors in Lipoprotein Metabolism.

    KIM Dong-ho( 担当: 単著)

    Lipoprotein Metabolism and Atherogenesis, Springer-Verlag  2000年 

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    著書種別:学術書  

MISC(その他記事)

  • Evolution of the Apolipoprotein E Receptor 2 Gene by Exon Loss. 査読

    KIM Dong-ho

    Journal of Biochemistry   124 ( 2 )   451 - 456   1998年

     詳細を見る

    掲載種別:記事・総説・解説・論説等(学術雑誌)   共著区分:単著  

  • cDNA Cloning of a New Low-Density Lipoprotein Receptor-Related Protein and Mapping of Its Gene (LRP3) to Chromosome Bands 19q12-q13.2. 査読

    ISHII H, KIM D‐H, FUJITA T, ENDO Y, SAEKI S, YAMAMOTO T T

    Genomics   51 ( 1 )   132 - 135   1998年( ISSN:0888-7543|1089-8646

     詳細を見る

    掲載種別:記事・総説・解説・論説等(学術雑誌)  

    DOI: 10.1006/geno.1998.5339

    PubMed

    CiNii Article

    J-GLOBAL

  • A Novel Low-Density Lipoprotein Receptor-Related Protein with Type II Membrane Protein-Like Structure Is Abundant in Heart. 査読

    KIM Dong-ho

    Journal of Biochemistry   124 ( 4 )   784 - 789   1998年

     詳細を見る

    掲載種別:記事・総説・解説・論説等(学術雑誌)   共著区分:単著  

  • A New Low Density Lipoprotein Receptor Related Protein, LRP5, is Expressed in Hepatocytes and Adrenal Cortex, and Recognizes Apolipoprotein E. 査読

    KIM Dong-ho

    Journal of Biochemistry   124 ( 6 )   1072 - 1076   1998年

     詳細を見る

    掲載種別:記事・総説・解説・論説等(学術雑誌)   共著区分:単著  

  • Exon/Intron Organization, Chromosome Localization, Alternative Splicing, and Transcription Units of the Human Apolipoprotein E Receptor 2 Gene. 査読

    KIM D‐H, MAGOORI K, INOUE T R, MAO C C, KIM H‐J, SUZUKI H, FUJITA T, SAEKI S, YAMAMOTO T T

    Journal of Biological Chemistry   272 ( 13 )   8498 - 8504   1997年( ISSN:0021-9258|1083-351X

     詳細を見る

    掲載種別:記事・総説・解説・論説等(学術雑誌)  

    DOI: 10.1074/jbc.272.13.8498

    PubMed

    CiNii Article

    J-GLOBAL

  • Human Apolipoprotein E Receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain. 査読

    KIM D‐H, IIJIMA H, GOTO K, SAKAI J, ISHII H, KIM H‐J, SUZUKI H, KONDO H, YAMAMOTO T

    Journal of Biological Chemistry   271 ( 14 )   8373 - 8380   1996年( ISSN:0021-9258|1083-351X

     詳細を見る

    掲載種別:記事・総説・解説・論説等(学術雑誌)  

    DOI: 10.1074/jbc.271.14.8373

    PubMed

    CiNii Article

    J-GLOBAL

▼全件表示

産学官連携可能研究(シーズ)概要

  • リポタンパク質代謝に関する分子栄養学的研究

    2000.4-2005.3

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    交流の種別:技術相談, 共同研究, 受託研究, 各種相談, 講演, 調査  

    活用分野・応用方法等:現在まで明らかになっているリポタンパク質レセプターに関する知識を用いてリポタンパク質代謝に関する研究が可能になる。

    本研究はLDLレセプターを初めとするリポタンパク質レセプターとリポタンパク質代謝に関する分子栄養学的研究である。

その他

  • 職務経歴

    2000年

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    大阪市立大学 助手