Updated on 2024/12/03

写真a

 
KAMIYA Tomonori
 
Organization
Graduate School of Medicine Department of Basic Medical Science Assistant Professor
School of Medicine Department of Medical Science
Title
Assistant Professor
Affiliation
Institute of Medicine
Homepage
http://www.med.osaka-cu.ac.jp/pathophysiology/
Profile
生体内の共生微生物が疾患発症、または恒常性維持への関与を対象とし、免疫学、バイオインフォマティクス、代謝物解析、細菌学、実験動物学的手法を用いて研究を実施している。
Affiliation campus
Abeno Campus

Position

  • Graduate School of Medicine Department of Basic Medical Science 

    Assistant Professor  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Assistant Professor  2022.04 - Now

Degree

  • Doctor(Science) （ The University of Tokyo ）

Research Areas

  • Life Science / Physiology  / pathophysiology, gut-immunology, Microbiology, Bioinformatics

Research Interests

  • 共生微生物、代謝物、免疫、肝臓、肥満、メタゲノム解析

Research subject summary

  • 腸内細菌による肝疾患促進/抑制メカニズムに関する研究

  • 共生微生物による疾患発症、恒常性維持機構の解明

Professional Memberships

  • 日本免疫学会

      Domestic

  • 日本がん免疫学会

  • 腸内細菌学会

Education

  • The University of Tokyo   Doctor's Course   Accomplished credits for doctoral program

    2011.04 - 2014.03

  • The University of Tokyo   Master's Course   Graduated/Completed

    2009.04 - 2011.03

  • Tokyo Institute of Technology     Graduated/Completed

    2005.04 - 2009.03

Papers

  • Oral Microbial Profile Analysis in Patients with Oral and Pharyngeal Cancer Reveals That Tumoral Fusobacterium nucleatum Promotes Oral Cancer Progression by Activating YAP. Reviewed

    Yamamoto Y, Kamiya T, Yano M, Huyen VT, Oishi M, Nishio M, Suzuki A, Sunami K, Ohtani N

    Microorganisms   11 ( 12 )   2023.12（ ISSN:2076-2607 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/microorganisms11122957

    PubMed

  • Visualization of hydrocarbon chain length and degree of saturation of fatty acids in mouse livers by combining near-infrared hyperspectral imaging and machine learning. Reviewed

    Mori A, Umezawa M, Okubo K, Kamiya T, Kamimura M, Ohtani N, Soga K

    Scientific reports   13 ( 1 )   20555   2023.11

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41598-023-47565-z

    PubMed

  • Recent updates on the role of the gut-liver axis in the pathogenesis of NAFLD/NASH, HCC, and beyond. Reviewed

    Ohtani N, Kamiya T, Kawada N

    Hepatology communications   7 ( 9 )   2023.09

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1097/HC9.0000000000000241

    PubMed

  • Characterization of Transcriptomic and Proteomic Changes in the Skin after Chronic Fluocinolone Acetonide Treatment. Reviewed

    Choi Y, Takasugi M, Takemura K, Yoshida Y, Kamiya T, Adachi J, Tsuruta D, Ohtani N

    Biomolecules   12 ( 12 )   2022.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/biom12121822

    PubMed

  • The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors.

    Kamiya T, Ohtani N

    International immunology   34 ( 9 )   467 - 474   2022.09（ ISSN:0953-8178 ） （ eISSN:14602377 ）

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    Publishing type：Research paper (scientific journal)  

    <jats:title>Abstract</jats:title><jats:p>Abstract</jats:p><jats:p>More than 500 species of microbiota reside in the human intestine and coexist with humans, their host. Gut microbial metabolites and components are absorbed from the intestine and influence cells in the liver, including hepatocytes and stromal cells, such as liver sinusoidal endothelial cells, hepatic stellate cells, Kupffer cells, natural killer (NK) cells, NK T cells and other immune cells. This gut-originated axis to the liver is called the “gut–liver axis”, which underscores the importance of the link between the gut and the liver. In this review, we discuss the gut microbial components and metabolites that affect cells in the liver, particularly in association with immune cells, and the related responses. We also highlight the mechanisms underlying gut microbiota-mediated liver carcinogenesis and discuss cancer prevention, including the recently clarified modulation of immune checkpoint inhibitor efficacy by the gut microbiota.</jats:p>

    DOI： 10.1093/intimm/dxac020

    PubMed

  • Gasdermin D-mediated release of IL-33 from senescent hepatic stellate cells promotes obesity-associated hepatocellular carcinoma. Reviewed

    Yamagishi R, Kamachi F, Nakamura M, Yamazaki S, Kamiya T, Takasugi M, Cheng Y, Nonaka Y, Yukawa-Muto Y, Thuy LTT, Harada Y, Arai T, Loo TM, Yoshimoto S, Ando T, Nakajima M, Taguchi H, Ishikawa T, Akiba H, Miyake S, Kubo M, Iwakura Y, Fukuda S, Chen WY, Kawada N, Rudensky A, Nakae S, Hara E, Ohtani N

    Science immunology   7 ( 72 )   eabl7209   2022.06

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1126/sciimmunol.abl7209

    PubMed

  • Distinct responsiveness to rifaximin in patients with hepatic encephalopathy depends on functional gut microbial species. Reviewed

    Yukawa-Muto Y, Kamiya T, Fujii H, Mori H, Toyoda A, Sato I, Konishi Y, Hirayama A, Hara E, Fukuda S, Kawada N, Ohtani N

    Hepatology communications   2022.04

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/hep4.1954

    PubMed

  • Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle. Reviewed

    Takada N, Takasugi M, Nonaka Y, Kamiya T, Takemura K, Satoh J, Ito S, Fujimoto K, Uematsu S, Yoshida K, Morita T, Nakamura H, Uezumi A, Ohtani N

    Development (Cambridge, England)   149 ( 3 )   2022.02（ ISSN:0950-1991 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1242/dev.199443

    PubMed

  • Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle. Reviewed

    Takada N, Takasugi M, Nonaka Y, Kamiya T, Takemura K, Satoh J, Ito S, Fujimoto K, Uematsu S, Yoshida K, Morita T, Nakamura H, Uezumi A, Ohtani N

    Development (Cambridge, England)   2022.01（ ISSN:0950-1991 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1242/dev.199443

    PubMed

  • Bioinformatics Analysis of Oral, Vaginal, and Rectal Microbial Profiles during Pregnancy: A Pilot Study on the Bacterial Co-Residence in Pregnant Women. Reviewed

    Fudaba M, Kamiya T, Tachibana D, Koyama M, Ohtani N

    Microorganisms   9 ( 5 )   2021.05

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/microorganisms9051027

    PubMed

  • Bioinformatics Analysis of Oral, Vaginal, and Rectal Microbial Profiles during Pregnancy: A Pilot Study on the Bacterial Co-Residence in Pregnant Women Reviewed

    Fudaba Megumi, Kamiya Tomonori, Tachibana Daisuke, Koyama Masayasu, Ohtani Naoko

    MICROORGANISMS   9 ( 5 )   2021.05

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/microorganisms9051027

    PubMed

  • Visualization of quantitative lipid distribution in mouse liver through near-infrared hyperspectral imaging Reviewed

    Okubo Kyohei, Kitagawa Yuichi, Hosokawa Naoki, Umezawa Masakazu, Kamimura Masao, Kamiya Tomonori, Ohtani Naoko, Soga Kohei

    BIOMEDICAL OPTICS EXPRESS   12 ( 2 )   823 - 835   2021.02（ ISSN:2156-7085 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/BOE.413712

    PubMed

  • Visualization of quantitative lipid distribution in mouse liver through near-infrared hyperspectral imaging. Reviewed

    Okubo K, Kitagawa Y, Hosokawa N, Umezawa M, Kamimura M, Kamiya T, Ohtani N, Soga K

    Biomedical optics express   12 ( 2 )   823 - 835   2021.02

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1364/BOE.413712

    PubMed

  • Gut microbial metabolite and obesity-associated liver cancer Reviewed

    Ohtani Naoko, Kamiya Tomonori, Kamachi Fumitaka, Yamagishi Ryota

    CANCER SCIENCE   112   1031 - 1031   2021.02（ ISSN:1347-9032 ）

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    Publishing type：Research paper (scientific journal)  

  • Suppression of IL-17F, but not of IL-17A, provides protection against colitis by inducing T-reg cells through modification of the intestinal microbiota Reviewed

    Tang Ce, Kakuta Shigeru, Shimizu Kenji, Kadoki Motohiko, Kamiya Tomonori, Shimazu Tomoyuki, Kubo Sachiko, Saijo Shinobu, Ishigame Harumichi, Nakae Susumu, Iwakura Yoichiro

    NATURE IMMUNOLOGY   19 ( 7 )   755 - +   2018.07（ ISSN:1529-2908 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/s41590-018-0134-y

    PubMed

  • β-Glucans in food modify colonic microflora by inducing antimicrobial protein, calprotectin, in a Dectin-1-induced-IL-17F-dependent manner Reviewed

    Kamiya. T, Tang. C, Kadoki. M, Oshima. K, Hattori. M, Saijo. S, Adachi. Y, Ohno. N, Iwakura. Y

    Mucosal Immunology   2018.05

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    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

  • An optimistic protein assembly from sequence reads salvaged an uncharacterized segment of mouse picobirnavirus. Reviewed

    Gonzalez G, Sasaki M, Burkitt-Gray L, Kamiya T, Tsuji NM, Sawa H, Ito K

    Scientific reports   7   40447   2017.01

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1038/srep40447

    PubMed

  • Improvement of Intestinal Immune Cell Function by Lactic Acid Bacteria for Dairy Products. Reviewed

    Kamiya T, Watanabe Y, Makino S, Kano H, Tsuji NM

    Microorganisms   5 ( 1 )   2016.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/microorganisms5010001

    PubMed

  • Visualization of Probiotic-Mediated Ca2+ Signaling in Intestinal Epithelial Cells In Vivo. Reviewed

    Adachi T, Kakuta S, Aihara Y, Kamiya T, Watanabe Y, Osakabe N, Hazato N, Miyawaki A, Yoshikawa S, Usami T, Karasuyama H, Kimoto-Nira H, Hirayama K, Tsuji NM

    Frontiers in immunology   7   601   2016.12

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3389/fimmu.2016.00601

    PubMed

  • Targeting C-type lectin receptors for cancer immunity Reviewed

    Huimin Yan, Tomomori Kamiya, Papawee Suabjakyong, Noriko M. Tsuji

    Frontiers Immunology   2015.08

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    Publishing type：Research paper (scientific journal)   Kind of work：Single Work  

  • Inhibition of Dectin-1 Signaling Ameliorates Colitis by Inducing Lactobacillus-Mediated Regulatory T Cell Expansion in the Intestine. Reviewed

    Tang C, Kamiya T, Liu Y, Kadoki M, Kakuta S, Oshima K, Hattori M, Takeshita K, Kanai T, Saijo S, Ohno N, Iwakura Y

    Cell host & microbe   18 ( 2 )   183 - 97   2015.08（ ISSN:1931-3128 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.chom.2015.07.003

    PubMed

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MISC

  • ニュートリションケア 腸内細菌と疾患のメカニズムを探る！ International journal

    ニュートリションケア   2024.10（ ISBN:4-8404-8409-0 ）

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  • 肝胆膵 特集/微小環境から読み解く肝癌 International journal

    アークメディア   2024.04（ ISSN:0389-4991 ）

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  • 【知っておくべきアレルギー・免疫の知識】腸内細菌叢と免疫 Reviewed

    神谷 知憲, 大谷 直子

    ENTONI   ( 292 )   69 - 79   2024.01（ ISSN:1346-2067 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    ヒトの腸内には500～1,000種類ほど,数にして40兆個以上の腸内細菌が存在するといわれている.腸内細菌は栄養素を産生したり,病原体の感染防御に役立つなど,宿主とよい関係性で共生し,宿主の生体恒常性維持に役立っている.近年,次世代シーケンサーによる大量のシーケンシング技術の発達により,菌のDNA解析が進み,様々な病態で腸内細菌叢の変化が生じていることがわかってきた.腸内細菌叢のdysbiosisにより,腸管免疫を含む宿主の免疫反応の乱れが生じ,宿主の病態発症につながることがある.近年,炎症性腸疾患などの消化管疾患だけでなく,肥満,非アルコール性脂肪肝炎など,腸から離れた様々な遠隔臓器の疾患・病態において腸内細菌叢のdysbiosisとの関連が報告されている.腸内細菌は周囲の免疫細胞へ影響を及ぼすが,それは多くの場合,菌体そのものの成分や腸内細菌が産生する代謝物質を介することが報告されている.本稿では,特に研究が進んでいる腸内細菌と炎症性腸疾患とのかかわりや,筆者が専門としている腸肝軸を介する肝疾患への影響を重点的に紹介する.(著者抄録)

  • 【腸内細菌学雑誌】常在細菌叢が関わる病態メカニズムの解明と疾患予防を目指して Invited Reviewed International journal

    神谷知憲, 大谷直子

    腸内細菌学会   37 ( 4 )   199 - 203   2023.10（ ISSN:1343-0882 ） （ eISSN:1349-8363 ）

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    Authorship：Lead author   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine：Domestic journal  

  • 【発がん研究の最前線～がんの原因解明から予防法開発まで～】大腸がん発症に対する腸内細菌叢の関与 Reviewed

    神谷 知憲, 大谷 直子

    Precision Medicine   6 ( 4 )   272 - 276   2023.04（ ISSN:2434-3625 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    ヒトと腸内細菌叢はお互い良い共生関係にあり,シンバイオーシス状態を保っているが,ひとたびそのホメオスタシスが崩れると,ディスバイオーシス状態になり様々な疾患の発症につながる可能性がある。がんもそのような腸内細菌のアンバランスにより影響を受ける疾患のひとつであろう。本稿では,大腸がん発症との関連が示されている3種の腸内細菌,Fusobacterium nucleatum,metalloproteaseを分泌するEnterotoxigenic B.fragilis(ETBF),腸内細菌種,DNAをアルキル化するコリバクチンを産生するpks陽性Escherichia coliの作用について紹介する。また,発がんとの関連する腸内細菌の代謝物についても言及する。(著者抄録)

  • 【マイクロバイオームが切り拓く肝胆膵の新未来】マイクロバイオームとがん Reviewed International journal

    神谷 知憲, 大谷 直子

    アークメディア   86 ( 3 )   289 - 297   2023.03（ ISSN:0389-4991 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)   International / domestic magazine：Domestic journal  

  • 腸内細菌叢により修飾される胆汁酸とTh17活性 Reviewed

    神谷 知憲, 大谷 直子

    臨床免疫・アレルギー科   78 ( 6 )   729 - 736   2022.12（ ISSN:1881-1930 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

  • 【Systemic Organ Interactions in Gastrointestinal Diseases】肝がん微小環境における免疫細胞の役割　腸内細菌叢由来因子の関与(The role of immune cells in the liver tumor microenvironment: an involvement of gut microbiota-derived factors) Reviewed

    Kamiya Tomonori, Ohtani Naoko

    International Immunology   34 ( 9 )   467 - 474   2022.09（ ISSN:0953-8178 ）

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    Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

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Presentations

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Grant-in-Aid for Scientific Research

  • CXCL9に着目したNAFLD/NASH肝がん発症機構の解明と治療法の開発

    Grant-in-Aid for Early-Career Scientists  2025

  • CXCL9に着目したNAFLD/NASH肝がん発症機構の解明と治療法の開発

    Grant-in-Aid for Early-Career Scientists  2024

  • 腸内細菌が代謝する新規機能性脂肪酸による肥満誘導性肝がん抑制機構の解明

    Grant-in-Aid for Early-Career Scientists  2020.04

  • 腸内細菌による新規脂肪酸代謝物の肝疾患に対する作用機構の解明

    Grant-in-Aid for Research Activity Start-up  2018.08

Outline of education staff

  • ・消化器系コース(消化管免疫と腸内細菌叢)
    ・機能系実習(血液、呼吸器)
    ・修業実習

Charge of on-campus class subject

  • 人体を考える

    2024   Weekly class   Graduate school

  • 機能系実習

    2023     Undergraduate

  • 修業実習

    2023     Undergraduate

  • 消化器系コース

    2023     Undergraduate

  • 医学研究推進コース1

    2023     Undergraduate

  • 機能系実習

    2022     Undergraduate

  • 消化器系コース

    2022     Undergraduate

  • 修業実習

    2022     Undergraduate

  • 医学研究推進コース1

    2022     Undergraduate

  • 修業実習

    2021     Undergraduate

  • 消化器系コース

    2021     Undergraduate

  • 機能系実習

    2021     Undergraduate

  • 医学研究推進コース1

    2021     Undergraduate

  • 消化器系コース

    2020     Undergraduate

  • 修業実習

    2020     Undergraduate

  • 機能系実習

    2020     Undergraduate

  • 修業実習

    2019     Undergraduate

  • 機能系実習

    2019     Undergraduate

  • 修業実習

    2018     Undergraduate

  • 機能系実習

    2018     Undergraduate

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Number of instructed thesis, researches

  • 2023

    Number of instructed the graduation thesis：2 

    [Number of instructed the Master's Program] (previous term)：3  [Number of instructed the Master's Program] (letter term)：4

  • 2022

    [Number of instructed the Master's Program] (previous term)：1  [Number of instructed the Master's Program] (letter term)：4

  • 2021

    Number of instructed the graduation thesis：2 

    [Number of instructed the Master's Program] (previous term)：1  [Number of instructed the Master's Program] (letter term)：5