-
Prime-boost-type PspA3 + 2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci.
Reviewed
Yokota C, Fujimoto K, Yamakawa N, Kono M, Miyaoka D, Shimohigoshi M, Uematsu M, Watanabe M, Kamei Y, Sugimoto A, Kawasaki N, Yabuno T, Okamura T, Kuroda E, Hamaguchi S, Sato S, Hotomi M, Akeda Y, Ishii KJ, Yasutomi Y, Sunami K, Uematsu S
Inflammation and regeneration
43
(
1
)
55
2023.11（ ISSN:1880-9693
）
-
Prime-boost-type PspA3+2 mucosal vaccine protects cynomolgus macaques from intratracheal challenge with pneumococci(タイトル和訳中)
Reviewed
Yokota Chieko, Fujimoto Kosuke, Yamakawa Natsuko, Kono Masamitsu, Miyaoka Daichi, Shimohigoshi Masaki, Uematsu Miho, Watanabe Miki, Kamei Yukari, Sugimoto Akira, Kawasaki Natsuko, Yabuno Takato, Okamura Tomotaka, Kuroda Eisuke, Hamaguchi Shigeto, Sato Shintaro, Hotomi Muneki, Akeda Yukihiro, Ishii Ken J., Yasutomi Yasuhiro, Sunami Kishiko, Uematsu Satoshi
Inflammation and Regeneration
43
1 of 12
-
12 of 12
2023.11（ ISSN:1880-9693
）
-
ggkegg: analysis and visualization of KEGG data utilizing the grammar of graphics.
Reviewed
Sato N, Uematsu M, Fujimoto K, Uematsu S, Imoto S
Bioinformatics (Oxford, England)
39
(
10
)
2023.10（ ISSN:1367-4803
）
-
Zero-shot-capable identification of phage-host relationships with whole-genome sequence representation by contrastive learning.
Reviewed
Zhang YZ, Liu Y, Bai Z, Fujimoto K, Uematsu S, Imoto S
Briefings in bioinformatics
24
(
5
)
2023.09（ ISSN:1467-5463
）
-
Orthognathic surgery with iliac bone grafting for an interpositional gap in a patient with type III hemifacial microsomia: A case report
Reviewed
Sugiyama M.
JPRAS Open
37
55
-
62
2023.09
-
Impact of neoadjuvant therapy on gut microbiome in patients with resectable/borderline resectable pancreatic ductal adenocarcinoma.
Reviewed
Ayaka Takaori, Daisuke Hashimoto, Tsukasa Ikeura, Takashi Ito, Koh Nakamaru, Masataka Masuda, Shinji Nakayama, So Yamaki, Tomohisa Yamamoto, Kosuke Fujimoto, Yoshiyuki Matsuo, Shohei Akagawa, Mitsuaki Ishida, Kiyoshi Yamaguchi, Seiya Imoto, Kiichi Hirota, Satoshi Uematsu, Sohei Satoi, Mitsugu Sekimoto, Makoto Naganuma
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
23
(
4
)
367
-
376
2023.06（ ISSN:1424-3903
）
-
The microsomal prostaglandin E synthase-1/PGE2 axis induces recovery from ischemia via recruitment of regulatory T cells.
Reviewed
Hideki Amano, Koji Eshima, Yoshiya Ito, Masaki Nakamura, Hidero Kitasato, Fumihiro Ogawa, Kanako Hosono, Kazuya Iwabuchi, Satoshi Uematsu, Shizuo Akira, Shuh Narumiya, Masataka Majima
Cardiovascular research
119
(
5
)
1218
-
1233
2023.05（ ISSN:0008-6363
）
-
Survey of physicians’ attitudes toward computerized tomography imaging for pediatric head trauma
Reviewed
Shimokawa S.
No To Hattatsu
55
(
1
)
27
-
33
2023（ ISSN:00290831
）
-
Characterization of the human gut virome in metabolic and autoimmune diseases.
Reviewed
Kosuke Fujimoto, Daichi Miyaoka, Satoshi Uematsu
Inflammation and regeneration
42
(
1
)
32
-
32
2022.11（ ISSN:1880-9693
）
-
Identification of bacteriophage genome sequences with representation learning.
Reviewed
Zeheng Bai, Yao-Zhong Zhang, Satoru Miyano, Rui Yamaguchi, Kosuke Fujimoto, Satoshi Uematsu, Seiya Imoto
Bioinformatics (Oxford, England)
38
(
18
)
4264
-
4270
2022.09
-
The Role of mPGES-1 in Promoting Granulation Tissue Angiogenesis Through Regulatory T-cell Accumulation.
Reviewed
Tetsuya Hyodo, Yoshiya Ito, Kanako Hosono, Satoshi Uematsu, Shizuo Akira, Masataka Majima, Akira Takeda, Hideki Amano
In vivo (Athens, Greece)
36
(
5
)
2061
-
2073
2022.09（ ISSN:0258-851X
）
-
Efficacy of Immune Checkpoint Inhibitor With or Without Chemotherapy for Nonsquamous NSCLC With Malignant Pleural Effusion: A Retrospective Multicenter Cohort Study
Reviewed
Kawachi H.
JTO Clinical and Research Reports
3
(
7
)
2022.07
-
Bronchoalveolar lavage fluid reveals factors contributing to the efficacy of PD-1 blockade in lung cancer.
Reviewed
Kentaro Masuhiro, Motohiro Tamiya, Kosuke Fujimoto, Shohei Koyama, Yujiro Naito, Akio Osa, Takashi Hirai, Hidekazu Suzuki, Norio Okamoto, Takayuki Shiroyama, Kazumi Nishino, Yuichi Adachi, Takuro Nii, Yumi Kinugasa-Katayama, Akiko Kajihara, Takayoshi Morita, Seiya Imoto, Satoshi Uematsu, Takuma Irie, Daisuke Okuzaki, Taiki Aoshi, Yoshito Takeda, Toru Kumagai, Tomonori Hirashima, Atsushi Kumanogoh
JCI insight
7
(
9
)
2022.05
-
Histologic transformation of epidermal growth factor receptor–mutated lung cancer
Reviewed
Fujimoto D.
European Journal of Cancer
166
41
-
50
2022.05（ ISSN:09598049
）
-
Galectin-3 promotes the adipogenic differentiation of PDGFRα+ cells and ectopic fat formation in regenerating muscle.
Reviewed
Naoki Takada, Masaki Takasugi, Yoshiki Nonaka, Tomonori Kamiya, Kazuaki Takemura, Junko Satoh, Shinji Ito, Kosuke Fujimoto, Satoshi Uematsu, Kayo Yoshida, Takashi Morita, Hiroaki Nakamura, Akiyoshi Uezumi, Naoko Ohtani
Development (Cambridge, England)
149
(
3
)
2022.02（ ISSN:0950-1991
）
-
Interferon-α exerts proinflammatory properties in experimental radiation-induced esophagitis: Possible involvement of plasmacytoid dendritic cells.
Reviewed
Hiroyuki Kitamura, Tetsuya Tanigawa, Takuya Kuzumoto, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Satoshi Uematsu, Toshio Watanabe, Yasuhiro Fujiwara
Life sciences
289
120215
-
120215
2022.01（ ISSN:0024-3205
）
-
腸内細菌叢を標的とした新規治療法の開発
植松 智
日本マス・スクリーニング学会誌.
32(2)
168
-
168
2022
-
腸内細菌の異常と制御法.
植松 智
日本ペインクリニック学会誌.
29(4)
64
-
64
2022
-
生活習慣病と病原常在腸内細菌.
植松 智
臨床免疫・アレルギー科.
77(6)
684
-
689
2022
-
いま知りたい!!ファージ療法は多剤耐性菌への切り札となるか 1 概論-ファージ療法の利点と課題.
植松 智, 井元 清哉
実験医学.
40(18)
2983
-
2985
2022
-
【自己免疫疾患 層別化する新時代へ 臨床検体のマルチオミクス解析、腸内細菌によって見えてきた免疫経路の全容】(第1章)精密医療を目指したマルチオミクス解析によるアプローチ メタゲノム解析からの層別化医療への展望.
植松 智, 井元 清哉
実験医学.
40(15)
2374
-
2379
2022
-
Phage therapy for Clostridioides difficile infection.
Reviewed
Kosuke Fujimoto, Satoshi Uematsu
Frontiers in immunology
13
1057892
-
1057892
2022
-
Dysbiosis関連疾患の新規治療法の開発.
植松 智
腸内細菌学雑誌
36(2)
66
-
67
2022
-
Ovariectomy-Induced Dysbiosis May Have a Minor Effect on Bone in Mice.
Reviewed
Satoshi Kosaka, Yuji Nadatani, Akira Higashimori, Koji Otani, Kosuke Fujimoto, Yuki Nagata, Masaki Ominami, Shusei Fukunaga, Shuhei Hosomi, Noriko Kamata, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Seiya Imoto, Satoshi Uematsu, Toshio Watanabe, Yasuhiro Fujiwara
Microorganisms
9
(
12
)
2021.12（ ISSN:2076-2607
）
-
Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization
Reviewed
Uematsu S.
Scientific Reports
11
(
1
)
2021.12
-
Oral MucoRice-CTB vaccine for safety and microbiota-dependent immunogenicity in humans: a phase 1 randomised trial
Reviewed
Yoshikazu Yuki, Masanori Nojima, Osamu Hosono, Hirotoshi Tanaka, Yasumasa Kimura, Takeshi Satoh, Seiya Imoto, Satoshi Uematsu, Shiho Kurokawa, Koji Kashima, Mio Mejima, Rika Nakahashi-Ouchida, Yohei Uchida, Takanori Marui, Noritada Yoshikawa, Fumitaka Nagamura, Kohtaro Fujihashi, Hiroshi Kiyono
The Lancet Microbe
2
(
9
)
e429
-
e440
2021.09（ ISSN:2666-5247
）
-
Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation.
Reviewed
Kosuke Fujimoto, Yasumasa Kimura, Jessica R Allegretti, Mako Yamamoto, Yao-Zhong Zhang, Kotoe Katayama, Georg Tremmel, Yunosuke Kawaguchi, Masaki Shimohigoshi, Tetsuya Hayashi, Miho Uematsu, Kiyoshi Yamaguchi, Yoichi Furukawa, Yutaka Akiyama, Rui Yamaguchi, Sheila E Crowe, Peter B Ernst, Satoru Miyano, Hiroshi Kiyono, Seiya Imoto, Satoshi Uematsu
Gastroenterology
160
(
6
)
2089
-
2102.e12
2021.05（ ISSN:0016-5085
）
-
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.
Reviewed
Yoshihiro Takasato, Yosuke Kurashima, Masahiro Kiuchi, Kiyoshi Hirahara, Sayuri Murasaki, Fujimi Arai, Kumi Izawa, Ayako Kaitani, Kaoru Shimada, Yukari Saito, Shota Toyoshima, Miho Nakamura, Kumiko Fujisawa, Yoshimichi Okayama, Jun Kunisawa, Masato Kubo, Naoki Takemura, Satoshi Uematsu, Shizuo Akira, Jiro Kitaura, Takao Takahashi, Toshinori Nakayama, Hiroshi Kiyono
Mucosal immunology
14
(
3
)
640
-
651
2021.05（ ISSN:1933-0219
）
-
Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation.
Reviewed
Fujimoto K, Kimura Y, Allegretti JR, Yamamoto M, Zhang YZ, Katayama K, Tremmel G, Kawaguchi Y, Shimohigoshi M, Hayashi T, Uematsu M, Yamaguchi K, Furukawa Y, Akiyama Y, Yamaguchi R, Crowe SE, Ernst PB, Miyano S, Kiyono H, Imoto S, Uematsu S
Gastroenterology
2021.02（ ISSN:0016-5085
）
-
Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice
Reviewed
Mukendi Jean Pierre Kambala, Nakamura Risa, Uematsu Satoshi, Hamano Shinjiro
PARASITES & VECTORS
14
(
1
)
70
2021.01（ ISSN:1756-3305
）
-
Fecal Microbiome Composition in Healthy Adults in Ghana
Parbie Prince Kofi, Mizutani Taketoshi, Ishizaka Aya, Kawana-Tachikawa Ai, Runtuwene Lucky Ronald, Seki Sayuri, Abana Christopher Zaab-Yen, Kushitor Dennis, Bonney Evelyn Yayra, Ofori Sampson Badu, Uematsu Satoshi, Imoto Seiya, Kimura Yasumasa, Kiyono Hiroshi, Ishikawa Koichi, Ampofo William Kwabena, Matano Tetsuro
Japanese Journal of Infectious Diseases
74
(
1
)
42
-
47
2021.01（ ISSN:1344-6304
）
（ eISSN:18842836
）
-
Interleukin (IL)-33 is dispensable for Schistosoma mansoni worm maturation and the maintenance of egg-induced pathology in intestines of infected mice.
Reviewed
Jean Pierre Kambala Mukendi, Risa Nakamura, Satoshi Uematsu, Shinjiro Hamano
Parasites & vectors
14
(
1
)
70
-
70
2021.01
-
Fecal Microbiome Composition in Healthy Adults in Ghana
Reviewed
Parbie Prince Kofi, Mizutani Taketoshi, Ishizaka Aya, Kawana-Tachikawa Ai, Runtuwene Lucky Ronald, Seki Sayuri, Abana Christopher Zaab-Yen, Kushitor Dennis, Bonney Evelyn Yayra, Ofori Sampson Badu, Uematsu Satoshi, Imoto Seiya, Kimura Yasumasa, Kiyono Hiroshi, Ishikawa Koichi, Ampofo William Kwabena, Matano Tetsuro
国立感染症研究所 Japanese Journal of Infectious Diseases 編集委員会 JAPANESE JOURNAL OF INFECTIOUS DISEASES
74
(
1
)
42
-
47
2021.01（ ISSN:1344-6304
）
-
Fecal Microbiome Composition in Healthy Adults in Ghana(和訳中)
Reviewed
Parbie Prince Kofi, Mizutani Taketoshi, Ishizaka Aya, Kawana-Tachikawa Ai, Runtuwene Lucky Ronald, Seki Sayuri, Abana Christopher Zaab-Yen, Kushitor Dennis, Bonney Evelyn Yayra, Ofori Sampson Badu, Uematsu Satoshi, Imoto Seiya, Kimura Yasumasa, Kiyono Hiroshi, Ishikawa Koichi, Ampofo William Kwabena, Matano Tetsuro
国立感染症研究所 Japanese Journal of Infectious Diseases
74
(
1
)
42
-
47
2021.01（ ISSN:1344-6304
）
-
ガーナの健常成人における腸内細菌叢組成(Fecal Microbiome Composition in Healthy Adults in Ghana)
Reviewed
Parbie Prince Kofi, Mizutani Taketoshi, Ishizaka Aya, Kawana-Tachikawa Ai, Runtuwene Lucky Ronald, Seki Sayuri, Abana Christopher Zaab-Yen, Kushitor Dennis, Bonney Evelyn Yayra, Ofori Sampson Badu, Uematsu Satoshi, Imoto Seiya, Kimura Yasumasa, Kiyono Hiroshi, Ishikawa Koichi, Ampofo William Kwabena, Matano Tetsuro
Japanese Journal of Infectious Diseases
74
(
1
)
42
-
47
2021.01（ ISSN:1344-6304
）
-
Dysbiotic Fecal Microbiome in HIV-1 Infected Individuals in Ghana.
Reviewed
Prince Kofi Parbie, Taketoshi Mizutani, Aya Ishizaka, Ai Kawana-Tachikawa, Lucky Ronald Runtuwene, Sayuri Seki, Christopher Zaab-Yen Abana, Dennis Kushitor, Evelyn Yayra Bonney, Sampson Badu Ofori, Satoshi Uematsu, Seiya Imoto, Yasumasa Kimura, Hiroshi Kiyono, Koichi Ishikawa, William Kwabena Ampofo, Tetsuro Matano
Frontiers in cellular and infection microbiology
11
646467
-
646467
2021
-
Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy
Reviewed
Takasato Yoshihiro, Kurashima Yosuke, Kiuchi Masahiro, Hirahara Kiyoshi, Murasaki Sayuri, Arai Fujimi, Izawa Kumi, Kaitani Ayako, Shimada Kaoru, Saito Yukari, Toyoshima Shota, Nakamura Miho, Fujisawa Kumiko, Okayama Yoshimichi, Kunisawa Jun, Kubo Masato, Takemura Naoki, Uematsu Satoshi, Akira Shizuo, Kitaura Jiro, Takahashi Takao, Nakayama Toshinori, Kiyono Hiroshi
MUCOSAL IMMUNOLOGY
2020.12（ ISSN:1933-0219
）
-
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota
Reviewed
Ishida Sachiko, Kato Kumiko, Tanaka Masami, Odamaki Toshitaka, Kubo Ryuichi, Mitsuyama Eri, Xiao Jin-zhong, Yamaguchi Rui, Uematsu Satoshi, Imoto Seiya, Miyano Satoru
COMMUNICATIONS BIOLOGY
3
(
1
)
686
2020.11
-
Genome-wide association studies and heritability analysis reveal the involvement of host genetics in the Japanese gut microbiota.
Reviewed
Sachiko Ishida, Kumiko Kato, Masami Tanaka, Toshitaka Odamaki, Ryuichi Kubo, Eri Mitsuyama, Jin-Zhong Xiao, Rui Yamaguchi, Satoshi Uematsu, Seiya Imoto, Satoru Miyano
Communications biology
3
(
1
)
686
-
686
2020.11
-
Alcohol abrogates human norovirus infectivity in a pH-dependent manner
Reviewed
Sato Shintaro, Matsumoto Naomi, Hisaie Kota, Uematsu Satoshi
SCIENTIFIC REPORTS
10
(
1
)
15878
2020.09（ ISSN:2045-2322
）
-
Alcohol abrogates human norovirus infectivity in a pH-dependent manner.
Reviewed
Shintaro Sato, Naomi Matsumoto, Kota Hisaie, Satoshi Uematsu
Scientific reports
10
(
1
)
15878
-
15878
2020.09
-
Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts
Reviewed
Fujimoto Kosuke, Kimura Yasumasa, Shimohigoshi Masaki, Satoh Takeshi, Sato Shintaro, Tremmel Georg, Uematsu Miho, Kawaguchi Yunosuke, Usui Yuki, Nakano Yoshiko, Hayashi Tetsuya, Kashima Koji, Yuki Yoshikazu, Yamaguchi Kiyoshi, Furukawa Yoichi, Kakuta Masanori, Akiyama Yutaka, Yamaguchi Rui, Crowe Sheila E., Ernst Peter B., Miyano Satoru, Kiyono Hiroshi, Imoto Seiya, Uematsu Satoshi
CELL HOST & MICROBE
28
(
3
)
380
-
+
2020.09（ ISSN:1931-3128
）
-
Metagenome Data on Intestinal Phage-Bacteria Associations Aids the Development of Phage Therapy against Pathobionts.
Reviewed
Kosuke Fujimoto, Yasumasa Kimura, Masaki Shimohigoshi, Takeshi Satoh, Shintaro Sato, Georg Tremmel, Miho Uematsu, Yunosuke Kawaguchi, Yuki Usui, Yoshiko Nakano, Tetsuya Hayashi, Koji Kashima, Yoshikazu Yuki, Kiyoshi Yamaguchi, Yoichi Furukawa, Masanori Kakuta, Yutaka Akiyama, Rui Yamaguchi, Sheila E Crowe, Peter B Ernst, Satoru Miyano, Hiroshi Kiyono, Seiya Imoto, Satoshi Uematsu
Cell host & microbe
28
(
3
)
380
-
389.e9
2020.09（ ISSN:1931-3128
）
-
Development of prime-boost-type next-generation mucosal vaccines.
Reviewed
Kosuke Fujimoto, Satoshi Uematsu
International immunology
32
(
9
)
597
-
603
2020.09（ ISSN:0953-8178
）
-
Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice
Reviewed
Takashima Shingo, Tanaka Fumio, Kawaguchi Yunoske, Usui Yuki, Fujimoto Kosuke, Nadatani Yuji, Otani Koji, Hosomi Shuhei, Nagami Yasuaki, Kamata Noriko, Taira Koichi, Tanigawa Tetsuya, Watanabe Toshio, Imoto Seiya, Uematsu Satoshi, Fujiwara Yasuhiro
NEUROGASTROENTEROLOGY AND MOTILITY
32
(
7
)
e13841
2020.07（ ISSN:1350-1925
）
-
Proton pump inhibitors enhance intestinal permeability via dysbiosis of gut microbiota under stressed conditions in mice.
Reviewed
Shingo Takashima, Fumio Tanaka, Yunosuke Kawaguchi, Yuki Usui, Kosuke Fujimoto, Yuji Nadatani, Koji Otani, Shuhei Hosomi, Yasuaki Nagami, Noriko Kamata, Koichi Taira, Tetsuya Tanigawa, Toshio Watanabe, Seiya Imoto, Satoshi Uematsu, Yasuhiro Fujiwara
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
32
(
7
)
e13841
2020.07（ ISSN:1350-1925
）
-
Vaccine therapy for dysbiosis-related diseases
Reviewed
Fujimoto Kosuke, Uematsu Satoshi
WORLD JOURNAL OF GASTROENTEROLOGY
26
(
21
)
2758
-
2767
2020.06（ ISSN:1007-9327
）
-
Vaccine therapy for dysbiosis-related diseases.
Reviewed
Kosuke Fujimoto, Satoshi Uematsu
World journal of gastroenterology
26
(
21
)
2758
-
2767
2020.06（ ISSN:1007-9327
）
-
Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b+Gr1+MDSCs from bone marrow.
Reviewed
Ryo Takahashi, Hideki Amano, Yoshiya Ito, Koji Eshima, Takefumi Satoh, Masatsugu Iwamura, Masaki Nakamura, Hidero Kitasato, Satoshi Uematsu, Joan Raouf, Per-Johan Jakobsson, Shizuo Akira, Masataka Majima
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
121
109581
-
109581
2020.01（ ISSN:0753-3322
）
-
Development of prime-boost-type next-generation mucosal vaccines.
Reviewed
Fujimoto K, Uematsu S
International immunology
2019.12（ ISSN:0953-8178
）
-
Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases.
Reviewed
Kosuke Fujimoto, Yunosuke Kawaguchi, Masaki Shimohigoshi, Yoshiyuki Gotoh, Yoshiko Nakano, Yuki Usui, Tetsuya Hayashi, Yasumasa Kimura, Miho Uematsu, Takuya Yamamoto, Yukihiro Akeda, Joon Haeng Rhee, Yoshikazu Yuki, Ken J Ishii, Sheila E Crowe, Peter B Ernst, Hiroshi Kiyono, Satoshi Uematsu
Gastroenterology
157
(
6
)
1530
-
1543.e4
2019.12（ ISSN:0016-5085
）
-
High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A.
Reviewed
Sugimura N, Otani K, Watanabe T, Nakatsu G, Shimada S, Fujimoto K, Nadatani Y, Hosomi S, Tanaka F, Kamata N, Taira K, Nagami Y, Tanigawa T, Uematsu S, Fujiwara Y
Scientific reports
9
(
1
)
16796
2019.11
-
High-fat diet-mediated dysbiosis exacerbates NSAID-induced small intestinal damage through the induction of interleukin-17A.
Reviewed
Naoki Sugimura, Koji Otani, Toshio Watanabe, Geicho Nakatsu, Sunao Shimada, Kosuke Fujimoto, Yuji Nadatani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Yasuaki Nagami, Tetsuya Tanigawa, Satoshi Uematsu, Yasuhiro Fujiwara
Scientific reports
9
(
1
)
16796
-
16796
2019.11（ ISSN:2045-2322
）
-
Microsomal prostaglandin E synthase-1 promotes lung metastasis via SDF-1/CXCR4-mediated recruitment of CD11b<sup>+</sup>Gr1<sup>+</sup>MDSCs from bone marrow.
Reviewed
Takahashi R, Amano H, Ito Y, Eshima K, Satoh T, Iwamura M, Nakamura M, Kitasato H, Uematsu S, Raouf J, Jakobsson PJ, Akira S, Majima M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
121
109581
2019.11（ ISSN:0753-3322
）
-
Diet-Induced Obese Mice and Leptin-Deficient Lep(ob/ob) Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms
Reviewed
Lee Eunyoung, Miedzybrodzka Emily L., Zhang Xilin, Hatano Ryo, Miyamoto Junki, Kimura Ikuo, Fujimoto Kosuke, Uematsu Satoshi, Rodriguez-Cuenca Sergio, Vidal-Puig Antonio, Gribble Fiona M., Reimann Frank, Miki Takashi
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
20
(
18
)
2019.09
-
Antigen-Specific Mucosal Immunity Regulates Development of Intestinal Bacteria-Mediated Diseases.
Reviewed
Fujimoto K, Kawaguchi Y, Shimohigoshi M, Gotoh Y, Nakano Y, Usui Y, Hayashi T, Kimura Y, Uematsu M, Yamamoto T, Akeda Y, Rhee JH, Yuki Y, Ishii KJ, Crowe SE, Ernst PB, Kiyono H, Uematsu S
Gastroenterology
2019.08（ ISSN:0016-5085
）
-
Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.
Reviewed
Ikeda-Matsuo Y, Miyata H, Mizoguchi T, Ohama E, Naito Y, Uematsu S, Akira S, Sasaki Y, Tanabe M
Neurobiology of disease
124
81
-
92
2019.04（ ISSN:0969-9961
）
-
Microsomal prostaglandin E synthase-1 is a critical factor in dopaminergic neurodegeneration in Parkinson's disease.
Reviewed
Ikeda-Matsuo Y, Miyata H, Mizoguchi T, Ohama E, Naito Y, Uematsu S, Akira S, Sasaki Y, Tanabe M
Neurobiology of disease
124
81
-
92
2019.04（ ISSN:0969-9961
）
-
Diet-Induced Obese Mice and Leptin-deficient Lepob/ob Mice Exhibit Increased Circulating GIP Levels Produced by Different Mechanisms
Reviewed
• Lee EY, Miedzbrodzka E, Zhang X, Hatano R, Miyamoto J, Kimura I, Fujimoto K, Uematsu S, Rodriguez-Cuenca S, Vidal-Puig A, Gribble FM, Reimann F, Miki T
Int J Mol Sci
20
4448
2019
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Induction of mPGES-1 in dopaminergic neurons contributes to neurodegeneration in Parkinson's disease
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Ikeda-Matsuo Yuri, Miyata Hajime, Mizoguchi Tomoko, Naito Yasuhito, Uematsu Satoshi, Akira Shizuo, Sasaki Yasuharu, Tanabe Mitsuo
Japanese Pharmacological Society, Proceedings for Annual Meeting of The Japanese Pharmacological Society
92
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0
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1
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O-16
2019
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腸内細菌叢（腸内フローラ）とは
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植松 智
糖尿病ケア
17(1)
9
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10
2019
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腸内細菌が乱れる原因と体に及ぼす影響
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植松 智
糖尿病ケア
17(1)
11
-
13
2019
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放射線腸障害に及ぼす好酸球の役割
藤本 康介, 植松 智
アレルギーの臨床
Vol.39(14)
13
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16
2019
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Induction of mPGES-1 in dopaminergic neurons contributes to neurodegeneration in Parkinson's disease
Ikeda-Matsuo Yuri, Miyata Hajime, Mizoguchi Tomoko, Naito Yasuhito, Uematsu Satoshi, Akira Shizuo, Sasaki Yasuharu, Tanabe Mitsuo
Proceedings for Annual Meeting of The Japanese Pharmacological Society
92
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0
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1-O-16
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O-16
2019（ eISSN:24354953
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Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway.
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Lee EY, Zhang X, Miyamoto J, Kimura I, Taknaka T, Furusawa K, Jomori T, Fujimoto K, Uematsu S, Miki T
The Journal of endocrinology
239
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3
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267
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276
2018.12（ ISSN:0022-0795
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Virome analysis in intestine
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Uematsu Satoshi
CANCER SCIENCE
109
348
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348
2018.12（ ISSN:1349-7006
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Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.
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Komine O, Yamashita H, Fujimori-Tonou N, Koike M, Jin S, Moriwaki Y, Endo F, Watanabe S, Uematsu S, Akira S, Uchiyama Y, Takahashi R, Misawa H, Yamanaka K
Cell death and differentiation
25
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12
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2130
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2146
2018.12（ ISSN:1350-9047
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Intestinal CD103(+) CD11b(+) cDC2 Conventional Dendritic Cells Are Required for Primary CD4(+) T and B Cell Responses to Soluble Flagellin
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Flores-Langarica Adriana, Cook Charlotte, Luda Katarzyna Muller, Persson Emma K., Marshall Jennifer L., Beristain-Covarrubias Nonantzin, Yam-Puc Juan Carlos, Dahlgren Madelene, Persson Jenny J., Uematsu Satoshi, Akira Shizuo, Henderson Ian R., Lindbom Bengt Johansson, Agace William, Cunningham Adam F.
FRONTIERS IN IMMUNOLOGY
9
2409
2018.10（ ISSN:1664-3224
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DUSP10 constrains innate IL-33-mediated cytokine production in ST2<sup>hi</sup> memory-type pathogenic Th2 cells.
Reviewed
Yamamoto T, Endo Y, Onodera A, Hirahara K, Asou HK, Nakajima T, Kanno T, Ouchi Y, Uematsu S, Nishimasu H, Nureki O, Tumes DJ, Shimojo N, Nakayama T
Nature communications
9
(
1
)
4231
2018.10
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Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice(和訳中)
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Usui Yuki, Kimura Yasumasa, Satoh Takeshi, Takemura Naoki, Ouchi Yasuo, Ohmiya Hiroko, Kobayashi Kyosuke, Suzuki Hiromi, Koyama Satomi, Hagiwara Satoko, Tanaka Hirotoshi, Imoto Seiya, Eberl Gerard, Asami Yukio, Fujimoto Kosuke, Uematsu Satoshi
Oxford University Press International Immunology
30
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7
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319
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331
2018.07（ ISSN:0953-8178
）
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Inhibition of microsomal prostaglandin E synthase-1 facilitates liver repair after hepatic injury in mice.
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Nishizawa N, Ito Y, Eshima K, Ohkubo H, Kojo K, Inoue T, Raouf J, Jakobsson PJ, Uematsu S, Akira S, Narumiya S, Watanabe M, Majima M
Journal of hepatology
69
(
1
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110
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120
2018.07（ ISSN:0168-8278
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Lactobacillus delbrueckii subsp. bulgaricus 2038とStreptococcus thermophilus 1131で発酵させたヨーグルトの長期摂取がマウスに及ぼす影響(Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice)
Reviewed
Usui Yuki, Kimura Yasumasa, Satoh Takeshi, Takemura Naoki, Ouchi Yasuo, Ohmiya Hiroko, Kobayashi Kyosuke, Suzuki Hiromi, Koyama Satomi, Hagiwara Satoko, Tanaka Hirotoshi, Imoto Seiya, Eberl Gerard, Asami Yukio, Fujimoto Kosuke, Uematsu Satoshi
International Immunology
30
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7
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319
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331
2018.07（ ISSN:0953-8178
）
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Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice.
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Usui Y, Kimura Y, Satoh T, Takemura N, Ouchi Y, Ohmiya H, Kobayashi K, Suzuki H, Koyama S, Hagiwara S, Tanaka H, Imoto S, Eberl G, Asami Y, Fujimoto K, Uematsu S
International immunology
30
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7
)
319
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331
2018.06（ ISSN:0953-8178
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Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing.
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Ouchi Y, Patil A, Tamura Y, Nishimasu H, Negishi A, Paul SK, Takemura N, Satoh T, Kimura Y, Kurachi M, Nureki O, Nakai K, Kiyono H, Uematsu S
International immunology
30
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4
)
141
-
154
2018.04（ ISSN:0953-8178
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Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing(和訳中)
Reviewed
Ouchi Yasuo, Patil Ashwini, Tamura Yusuke, Nishimasu Hiroshi, Negishi Aina, Paul Sudip Kumar, Takemura Naoki, Satoh Takeshi, Kimura Yasumasa, Kurachi Makoto, Nureki Osamu, Nakai Kenta, Kiyono Hiroshi, Uematsu Satoshi
Oxford University Press International Immunology
30
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4
)
141
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154
2018.04（ ISSN:0953-8178
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高効率なCRISPR/Cas9ゲノム編集によって抗腫瘍活性が増強された腫瘍抗原特異的マウスCD8+T細胞の作製(Generation of tumor antigen-specific murine CD8+ T cells with enhanced anti-tumor activity via highly efficient CRISPR/Cas9 genome editing)
Reviewed
Ouchi Yasuo, Patil Ashwini, Tamura Yusuke, Nishimasu Hiroshi, Negishi Aina, Paul Sudip Kumar, Takemura Naoki, Satoh Takeshi, Kimura Yasumasa, Kurachi Makoto, Nureki Osamu, Nakai Kenta, Kiyono Hiroshi, Uematsu Satoshi
International Immunology
30
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4
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141
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154
2018.04（ ISSN:0953-8178
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Eosinophil depletion suppresses radiation-induced small intestinal fibrosis.
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Takemura N, Kurashima Y, Mori Y, Okada K, Ogino T, Osawa H, Matsuno H, Aayam L, Kaneto S, Park EJ, Sato S, Matsunaga K, Tamura Y, Ouchi Y, Kumagai Y, Kobayashi D, Suzuki Y, Yoshioka Y, Nishimura J, Mori M, Ishii KJ, Rothenberg ME, Kiyono H, Akira S, Uematsu S
Science translational medicine
10
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429
)
2018.02（ ISSN:1946-6234
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A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.
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Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, Takemura N, Uematsu S, Lai CY, Otsu M, Matsuno H, Osawa H, Mizushima T, Nishimura J, Hayashi M, Yamaguchi T, Kiyono H
Stem cell reports
10
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1
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314
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2018.01
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Herpes simplex virus-1 evasion of CD8+ T cell accumulation contributes to viral encephalitis.
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Koyanagi N, Imai T, Shindo K, Sato A, Fujii W, Ichinohe T, Takemura N, Kakuta S, Uematsu S, Kiyono H, Maruzuru Y, Arii J, Kato A, Kawaguchi Y
The Journal of clinical investigation
127
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10
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3784
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3795
2017.10（ ISSN:0021-9738
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Intestinal microbiota link lymphopenia to murine autoimmunity via PD-1<sup>+</sup>CXCR5<sup>-/dim</sup> B-helper T cell induction.
Reviewed
Eri T, Kawahata K, Kanzaki T, Imamura M, Michishita K, Akahira L, Bannai E, Yoshikawa N, Kimura Y, Satoh T, Uematsu S, Tanaka H, Yamamoto K
Scientific reports
7
46037
2017.04
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G-CSF-induced sympathetic tone provokes fever and primes antimobilizing functions of neutrophils via PGE2.
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Kawano Y, Fukui C, Shinohara M, Wakahashi K, Ishii S, Suzuki T, Sato M, Asada N, Kawano H, Minagawa K, Sada A, Furuyashiki T, Uematsu S, Akira S, Uede T, Narumiya S, Matsui T, Katayama Y
Blood
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2017.02（ ISSN:0006-4971
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Mucosal Mesenchymal Cells: Secondary Barrier and Peripheral Educator for the Gut Immune System.
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Kurashima Y, Yamamoto D, Nelson S, Uematsu S, Ernst PB, Nakayama T, Kiyono H
Frontiers in immunology
8
1787
2017
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Inhaled Fine Particles Induce Alveolar Macrophage Death and Interleukin-1α Release to Promote Inducible Bronchus-Associated Lymphoid Tissue Formation.
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Kuroda E, Ozasa K, Temizoz B, Ohata K, Koo CX, Kanuma T, Kusakabe T, Kobari S, Horie M, Morimoto Y, Nakajima S, Kabashima K, Ziegler SF, Iwakura Y, Ise W, Kurosaki T, Nagatake T, Kunisawa J, Takemura N, Uematsu S, Hayashi M, Aoshi T, Kobiyama K, Coban C, Ishii KJ
Immunity
45
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6
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1299
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1310
2016.12（ ISSN:1074-7613
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Epithelial glycosylation in gut homeostasis and inflammation.
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Goto Y, Uematsu S, Kiyono H
Nature immunology
17
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11
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1244
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1251
2016.10（ ISSN:1529-2908
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p53 Is a Host Cell Regulator during Herpes Simplex Encephalitis.
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Maruzuru Y, Koyanagi N, Takemura N, Uematsu S, Matsubara D, Suzuki Y, Arii J, Kato A, Kawaguchi Y
Journal of virology
90
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15
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6738
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6745
2016.08（ ISSN:0022-538X
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Isolation and Functional Analysis of Lamina Propria Dendritic Cells from the Mouse Small Intestine.
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Takemura N, Uematsu S
Methods in molecular biology (Clifton, N.J.)
1422
181
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8
2016（ ISSN:1064-3745
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Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.
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Inada M, Takita M, Yokoyama S, Watanabe K, Tominari T, Matsumoto C, Hirata M, Maru Y, Maruyama T, Sugimoto Y, Narumiya S, Uematsu S, Akira S, Murphy G, Nagase H, Miyaura C
The Journal of biological chemistry
290
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29781
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93
2015.12（ ISSN:0021-9258
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Roles of mPGES-1, an inducible prostaglandin E synthase, in enhancement of LPS-induced lymphangiogenesis in a mouse peritonitis model.
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Matsuda H, Hosono K, Tsuru S, Kurashige C, Sekiguchi K, Akira S, Uematsu S, Okamoto H, Majima M
Life sciences
142
1
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7
2015.12（ ISSN:0024-3205
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Soluble flagellin coimmunization attenuates Th1 priming to Salmonella and clearance by modulating dendritic cell activation and cytokine production.
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Flores-Langarica A, Bobat S, Marshall JL, Yam-Puc JC, Cook CN, Serre K, Kingsley RA, Flores-Romo L, Uematsu S, Akira S, Henderson IR, Toellner KM, Cunningham AF
European journal of immunology
45
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8
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2299
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311
2015.08（ ISSN:0014-2980
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5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
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Maruyama K, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S
The Journal of biological chemistry
290
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15
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9377
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86
2015.04（ ISSN:0021-9258
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Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9.
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Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ
European journal of immunology
45
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2
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513
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24
2015.02（ ISSN:0014-2980
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MyD88 signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus.
Reviewed
Reynolds LA, Harcus Y, Smith KA, Webb LM, Hewitson JP, Ross EA, Brown S, Uematsu S, Akira S, Gray D, Gray M, MacDonald AS, Cunningham AF, Maizels RM
Journal of immunology (Baltimore, Md. : 1950)
193
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6
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2984
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93
2014.09（ ISSN:0022-1767
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Innate lymphoid cells regulate intestinal epithelial cell glycosylation.
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Goto Y, Obata T, Kunisawa J, Sato S, Ivanov II, Lamichhane A, Takeyama N, Kamioka M, Sakamoto M, Matsuki T, Setoyama H, Imaoka A, Uematsu S, Akira S, Domino SE, Kulig P, Becher B, Renauld JC, Sasakawa C, Umesaki Y, Benno Y, Kiyono H
Science (New York, N.Y.)
345
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2014.09（ ISSN:0036-8075
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Blockade of TLR3 protects mice from lethal radiation-induced gastrointestinal syndrome.
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Takemura N, Kawasaki T, Kunisawa J, Sato S, Lamichhane A, Kobiyama K, Aoshi T, Ito J, Mizuguchi K, Karuppuchamy T, Matsunaga K, Miyatake S, Mori N, Tsujimura T, Satoh T, Kumagai Y, Kawai T, Standley DM, Ishii KJ, Kiyono H, Akira S, Uematsu S
Nature communications
5
3492
2014.03
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Prevention of intestinal allergy in mice by rflaA:Ova is associated with enforced antigen processing and TLR5-dependent IL-10 secretion by mDC.
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Schülke S, Wolfheimer S, Gadermaier G, Wangorsch A, Siebeneicher S, Briza P, Spreitzer I, Schiller D, Loeschner B, Uematsu S, Ryffel B, Akira S, Waibler Z, Vieths S, Toda M, Scheurer S
PloS one
9
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2
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e87822
2014
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Increased Th17-inducing activity of CD14+ CD163 low myeloid cells in intestinal lamina propria of patients with Crohn's disease.
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Ogino T, Nishimura J, Barman S, Kayama H, Uematsu S, Okuzaki D, Osawa H, Haraguchi N, Uemura M, Hata T, Takemasa I, Mizushima T, Yamamoto H, Takeda K, Doki Y, Mori M
Gastroenterology
145
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6
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1380
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91.e1
2013.12（ ISSN:0016-5085
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Prostaglandin E₂ is critical for the development of niacin-deficiency-induced photosensitivity via ROS production.
Reviewed
Sugita K, Ikenouchi-Sugita A, Nakayama Y, Yoshioka H, Nomura T, Sakabe J, Nakahigashi K, Kuroda E, Uematsu S, Nakamura J, Akira S, Nakamura M, Narumiya S, Miyachi Y, Tokura Y, Kabashima K
Scientific reports
3
2973
2013.10
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DNA-Encoded Flagellin Activates Toll-Like Receptor 5 (TLR5), Nod-like Receptor Family CARD Domain-Containing Protein 4 (NRLC4), and Acts as an Epidermal, Systemic, and Mucosal-Adjuvant.
Reviewed
Nyström S, Bråve A, Falkeborn T, Devito C, Rissiek B, Johansson DX, Schröder U, Uematsu S, Akira S, Hinkula J, Applequist SE
Vaccines
1
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4
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415
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43
2013.09
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Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.
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Maruyama K, Uematsu S, Kondo T, Takeuchi O, Martino MM, Kawasaki T, Akira S
The Journal of experimental medicine
210
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10
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1947
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60
2013.09（ ISSN:0022-1007
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Flagellin enhances tumor-specific CD8⁺ T cell immune responses through TLR5 stimulation in a therapeutic cancer vaccine model.
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Nguyen CT, Hong SH, Sin JI, Vu HV, Jeong K, Cho KO, Uematsu S, Akira S, Lee SE, Rhee JH
Vaccine
31
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37
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3879
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87
2013.08（ ISSN:0264-410X
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Microsomal prostaglandin E synthase-1 is induced in alzheimer's disease and its deletion mitigates alzheimer's disease-like pathology in a mouse model.
Reviewed
Akitake Y, Nakatani Y, Kamei D, Hosokawa M, Akatsu H, Uematsu S, Akira S, Kudo I, Hara S, Takahashi M
Journal of neuroscience research
91
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7
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909
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19
2013.07（ ISSN:0360-4012
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Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.
Reviewed
Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, Kaneko D, Kumagai Y, You DJ, Carreras J, Uematsu S, Jang MH, Takeuchi O, Kaisho T, Akira S, Miyake K, Tsutsui H, Saito T, Nishimura I, Tsuji NM
Immunity
38
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6
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1187
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97
2013.06（ ISSN:1074-7613
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Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
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Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O
Journal of immunology (Baltimore, Md. : 1950)
190
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11
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5702
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11
2013.06（ ISSN:0022-1767
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Bacterial sphingophospholipids containing non-hydroxy fatty acid activate murine macrophages via Toll-like receptor 4 and stimulate bacterial clearance
Reviewed
Fujiwara Nagatoshi, Porcelli Steven A., Naka Takashi, Yano Ikuya, Maeda Shinji, Kuwata Hirotaka, Akira Shizuo, Uematsu Satoshi, Takii Takemasa, Ogura Hisashi, Kobayashi Kazuo
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
1831
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6
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1177
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1184
2013.06（ ISSN:1388-1981
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Toll-like receptor 7 gene deficiency and early-life Pneumovirus infection interact to predispose toward the development of asthma-like pathology in mice.
Reviewed
Kaiko GE, Loh Z, Spann K, Lynch JP, Lalwani A, Zheng Z, Davidson S, Uematsu S, Akira S, Hayball J, Diener KR, Baines KJ, Simpson JL, Foster PS, Phipps S
The Journal of allergy and clinical immunology
131
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5
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1331
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9.e10
2013.05（ ISSN:0091-6749
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Commensal microbiota drive proliferation of conventional and Foxp3(+) regulatory CD4(+) T cells in mesenteric lymph nodes and Peyer's patches.
Reviewed
Cording S, Fleissner D, Heimesaat MM, Bereswill S, Loddenkemper C, Uematsu S, Akira S, Hamann A, Huehn J
European journal of microbiology & immunology
3
(
1
)
1
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10
2013.03（ ISSN:2062-509X
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Microsomal prostaglandin E synthase-1 aggravates inflammation and demyelination in a mouse model of multiple sclerosis.
Reviewed
Takeuchi C, Matsumoto Y, Kohyama K, Uematsu S, Akira S, Yamagata K, Takemiya T
Neurochemistry international
62
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3
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271
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80
2013.02（ ISSN:0197-0186
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Systemic flagellin immunization stimulates mucosal CD103+ dendritic cells and drives Foxp3+ regulatory T cell and IgA responses in the mesenteric lymph node.
Reviewed
Flores-Langarica A, Marshall JL, Hitchcock J, Cook C, Jobanputra J, Bobat S, Ross EA, Coughlan RE, Henderson IR, Uematsu S, Akira S, Cunningham AF
Journal of immunology (Baltimore, Md. : 1950)
189
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5745
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54
2012.12（ ISSN:0022-1767
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好中球、古典的単球、樹状細胞における細胞表面でのTLR5のPRAT4A依存的発現(PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells)
Reviewed
Shibata Takuma, Takemura Naoki, Motoi Yuji, Goto Yoshiyuki, Karuppuchamy Thangaraj, Izawa Kumi, Li Xiaobing, Akashi-Takamura Sachiko, Tanimura Natsuko, Kunisawa Jun, Kiyono Hiroshi, Akira Shizuo, Kitamura Toshio, Kitaura Jiro, Uematsu Satoshi, Miyake Kensuke
Oxford University Press International Immunology
24
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10
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613
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623
2012.10（ ISSN:0953-8178
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PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells.
Reviewed
Shibata T, Takemura N, Motoi Y, Goto Y, Karuppuchamy T, Izawa K, Li X, Akashi-Takamura S, Tanimura N, Kunisawa J, Kiyono H, Akira S, Kitamura T, Kitaura J, Uematsu S, Miyake K
International immunology
24
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10
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613
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23
2012.10（ ISSN:0953-8178
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好中球、古典的単球、樹状細胞における細胞表面でのTLR5のPRAT4A依存的発現(PRAT4A-dependent expression of cell surface TLR5 on neutrophils, classical monocytes and dendritic cells)
Reviewed
Shibata Takuma, Takemura Naoki, Motoi Yuji, Goto Yoshiyuki, Karuppuchamy Thangaraj, Izawa Kumi, Li Xiaobing, Akashi-Takamura Sachiko, Tanimura Natsuko, Kunisawa Jun, Kiyono Hiroshi, Akira Shizuo, Kitamura Toshio, Kitaura Jiro, Uematsu Satoshi, Miyake Kensuke
International Immunology
24
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10
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613
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623
2012.10（ ISSN:0953-8178
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Deletion of microsomal prostaglandin E synthase-1 protects neuronal cells from cytotoxic effects of β-amyloid peptide fragment 31-35.
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Kuroki Y, Sasaki Y, Kamei D, Akitake Y, Takahashi M, Uematsu S, Akira S, Nakatani Y, Kudo I, Hara S
Biochemical and biophysical research communications
424
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3
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409
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13
2012.08（ ISSN:0006-291X
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Leukemia inhibitory factor coordinates the down-regulation of the visual cycle in the retina and retinal-pigmented epithelium.
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Chucair-Elliott AJ, Elliott MH, Wang J, Moiseyev GP, Ma JX, Politi LE, Rotstein NP, Akira S, Uematsu S, Ash JD
The Journal of biological chemistry
287
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29
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24092
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102
2012.07（ ISSN:0021-9258
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Critical role of microsomal prostaglandin E synthase-1 in the hydronephrosis caused by lactational exposure to dioxin in mice.
Reviewed
Yoshioka W, Aida-Yasuoka K, Fujisawa N, Kawaguchi T, Ohsako S, Hara S, Uematsu S, Akira S, Tohyama C
Toxicological sciences : an official journal of the Society of Toxicology
127
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2
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547
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54
2012.06（ ISSN:1096-6080
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Antibody-antigen-adjuvant conjugates enable co-delivery of antigen and adjuvant to dendritic cells in cis but only have partial targeting specificity.
Reviewed
Kreutz M, Giquel B, Hu Q, Abuknesha R, Uematsu S, Akira S, Nestle FO, Diebold SS
PloS one
7
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7
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e40208
2012
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The protective role of TLR6 in a mouse model of asthma is mediated by IL-23 and IL-17A.
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Moreira AP, Cavassani KA, Ismailoglu UB, Hullinger R, Dunleavy MP, Knight DA, Kunkel SL, Uematsu S, Akira S, Hogaboam CM
The Journal of clinical investigation
121
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11
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4420
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32
2011.11（ ISSN:0021-9738
）
-
A new subset of CD103+CD8alpha+ dendritic cells in the small intestine expresses TLR3, TLR7, and TLR9 and induces Th1 response and CTL activity.
Reviewed
Fujimoto K, Karuppuchamy T, Takemura N, Shimohigoshi M, Machida T, Haseda Y, Aoshi T, Ishii KJ, Akira S, Uematsu S
Journal of immunology (Baltimore, Md. : 1950)
186
(
11
)
6287
-
95
2011.06（ ISSN:0022-1767
）
-
Plasmacytoid dendritic cells promote host defense against acute pneumovirus infection via the TLR7-MyD88-dependent signaling pathway.
Reviewed
Davidson S, Kaiko G, Loh Z, Lalwani A, Zhang V, Spann K, Foo SY, Hansbro N, Uematsu S, Akira S, Matthaei KI, Rosenberg HF, Foster PS, Phipps S
Journal of immunology (Baltimore, Md. : 1950)
186
(
10
)
5938
-
48
2011.05（ ISSN:0022-1767
）
-
TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen.
Reviewed
Letran SE, Lee SJ, Atif SM, Flores-Langarica A, Uematsu S, Akira S, Cunningham AF, McSorley SJ
Journal of immunology (Baltimore, Md. : 1950)
186
(
9
)
5406
-
12
2011.05（ ISSN:0022-1767
）
-
Silica crystals and aluminum salts regulate the production of prostaglandin in macrophages via NALP3 inflammasome-independent mechanisms.
Reviewed
Kuroda E, Ishii KJ, Uematsu S, Ohata K, Coban C, Akira S, Aritake K, Urade Y, Morimoto Y
Immunity
34
(
4
)
514
-
26
2011.04（ ISSN:1074-7613
）
-
Microsomal prostaglandin E synthase-1 enhances bone cancer growth and bone cancer-related pain behaviors in mice.
Reviewed
Isono M, Suzuki T, Hosono K, Hayashi I, Sakagami H, Uematsu S, Akira S, DeClerck YA, Okamoto H, Majima M
Life sciences
88
(
15-16
)
693
-
700
2011.04（ ISSN:0024-3205
）
-
Antigen-specific T-cell responses to a recombinant fowlpox virus are dependent on MyD88 and interleukin-18 and independent of Toll-like receptor 7 (TLR7)- and TLR9-mediated innate immune recognition.
Reviewed
Lousberg EL, Diener KR, Fraser CK, Phipps S, Foster PS, Chen W, Uematsu S, Akira S, Robertson SA, Brown MP, Hayball JD
Journal of virology
85
(
7
)
3385
-
96
2011.04（ ISSN:0022-538X
）
-
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells.
Reviewed
Saitoh T, Satoh T, Yamamoto N, Uematsu S, Takeuchi O, Kawai T, Akira S
Immunity
34
(
3
)
352
-
63
2011.03（ ISSN:1074-7613
）
-
宿主における誘導型prostaglandin E synthase mPGES-1の腫瘍血管新生促進における役割(Roles of an inducible prostaglandin E synthase, mPGES-1 in host in enhancement of tumor-associated angiogenesis)
Reviewed
Kamata Hiroki, Hosono Kanako, Suzuki Tatsunori, Ogawa Yasufumi, Kubo Hidefumi, Katoh Hiroshi, Ito Yoshiya, Uematsu Satoshi, Akira Shizuo, Watanabe Masahiko, Majima Masataka
北里医学会 The Kitasato Medical Journal
41
(
1
)
19
-
30
2011.03（ ISSN:1349-8568
）
-
Endothelial microsomal prostaglandin E synthase-1 facilitates neurotoxicity by elevating astrocytic Ca2+ levels.
Reviewed
Takemiya T, Matsumura K, Sugiura H, Yasuda S, Uematsu S, Akira S, Yamagata K
Neurochemistry international
58
(
4
)
489
-
96
2011.03（ ISSN:0197-0186
）
-
宿主における誘導型prostaglandin E synthase mPGES-1の腫瘍血管新生促進における役割(Roles of an inducible prostaglandin E synthase, mPGES-1 in host in enhancement of tumor-associated angiogenesis)
Reviewed
Kamata Hiroki, Hosono Kanako, Suzuki Tatsunori, Ogawa Yasufumi, Kubo Hidefumi, Katoh Hiroshi, Ito Yoshiya, Uematsu Satoshi, Akira Shizuo, Watanabe Masahiko, Majima Masataka
The Kitasato Medical Journal
41
(
1
)
19
-
30
2011.03（ ISSN:1349-8568
）
-
The inducible prostaglandin E synthase mPGES-1 regulates growth of endometrial tissues and angiogenesis in a mouse implantation model.
Reviewed
Numao A, Hosono K, Suzuki T, Hayashi I, Uematsu S, Akira S, Ogino Y, Kawauchi H, Unno N, Majima M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
65
(
1
)
77
-
84
2011.02（ ISSN:0753-3322
）
-
Type I interferon signaling regulates Ly6C(hi) monocytes and neutrophils during acute viral pneumonia in mice.
Reviewed
Seo SU, Kwon HJ, Ko HJ, Byun YH, Seong BL, Uematsu S, Akira S, Kweon MN
PLoS pathogens
7
(
2
)
e1001304
2011.02（ ISSN:1553-7366
）
-
TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.
Reviewed
Letran SE, Lee SJ, Atif SM, Uematsu S, Akira S, McSorley SJ
European journal of immunology
41
(
1
)
29
-
38
2011.01（ ISSN:0014-2980
）
-
Airway epithelial indoleamine 2,3-dioxygenase inhibits CD4+ T cells during Aspergillus fumigatus antigen exposure.
Reviewed
Paveglio SA, Allard J, Foster Hodgkins SR, Ather JL, Bevelander M, Campbell JM, Whittaker LeClair LA, McCarthy SM, van der Vliet A, Suratt BT, Boyson JE, Uematsu S, Akira S, Poynter ME
American journal of respiratory cell and molecular biology
44
(
1
)
11
-
23
2011.01（ ISSN:1044-1549
）
-
Role of adrenomedullin in Lyme disease.
Reviewed
Marre ML, Darcy CT, Yinh J, Akira S, Uematsu S, Steere AC, Hu LT
Infection and immunity
78
(
12
)
5307
-
13
2010.12（ ISSN:0019-9567
）
-
Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.
Reviewed
Ae T, Ohno T, Hattori Y, Suzuki T, Hosono K, Minamino T, Sato T, Uematsu S, Akira S, Koizumi W, Majima M
American journal of physiology. Gastrointestinal and liver physiology
299
(
5
)
G1139
-
46
2010.11（ ISSN:0193-1857
）
-
The innate immune system in the intestine.
Reviewed
Uematsu S, Fujimoto K
Microbiology and immunology
54
(
11
)
645
-
57
2010.11（ ISSN:0385-5600
）
-
Apolipoprotein CIII induces monocyte chemoattractant protein-1 and interleukin 6 expression via Toll-like receptor 2 pathway in mouse adipocytes.
Reviewed
Abe Y, Kawakami A, Osaka M, Uematsu S, Akira S, Shimokado K, Sacks FM, Yoshida M
Arteriosclerosis, thrombosis, and vascular biology
30
(
11
)
2242
-
8
2010.11（ ISSN:1079-5642
）
-
Pathways regulating cytosolic phospholipase A2 activation and eicosanoid production in macrophages by Candida albicans.
Reviewed
Suram S, Gangelhoff TA, Taylor PR, Rosas M, Brown GD, Bonventre JV, Akira S, Uematsu S, Williams DL, Murphy RC, Leslie CC
The Journal of biological chemistry
285
(
40
)
30676
-
85
2010.10（ ISSN:0021-9258
）
-
mPGES-1-expressing bone marrow-derived cells enhance tumor growth and angiogenesis in mice.
Reviewed
Kamata H, Hosono K, Suzuki T, Ogawa Y, Kubo H, Katoh H, Ito Y, Uematsu S, Akira S, Watanabe M, Majima M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
64
(
6
)
409
-
16
2010.07（ ISSN:0753-3322
）
-
Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells.
Reviewed
Pan ZJ, Maier S, Schwarz K, Azbill J, Akira S, Uematsu S, Farris AD
Annals of the rheumatic diseases
69
(
6
)
1195
-
9
2010.06（ ISSN:0003-4967
）
-
Critical role of TLR7 in the acceleration of systemic lupus erythematosus in TLR9-deficient mice.
Reviewed
Santiago-Raber ML, Dunand-Sauthier I, Wu T, Li QZ, Uematsu S, Akira S, Reith W, Mohan C, Kotzin BL, Izui S
Journal of autoimmunity
34
(
4
)
339
-
48
2010.06（ ISSN:0896-8411
）
-
Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.
Reviewed
Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Núñez G, Suzuki T
Journal of immunology (Baltimore, Md. : 1950)
184
(
9
)
5287
-
97
2010.05（ ISSN:0022-1767
）
-
Toll-like receptor 6 drives interleukin-17A expression during experimental hypersensitivity pneumonitis.
Reviewed
Fong DJ, Hogaboam CM, Matsuno Y, Akira S, Uematsu S, Joshi AD
Immunology
130
(
1
)
125
-
36
2010.05（ ISSN:0019-2805
）
-
Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists.
Reviewed
Rajagopal D, Paturel C, Morel Y, Uematsu S, Akira S, Diebold SS
Blood
115
(
10
)
1949
-
57
2010.03（ ISSN:0006-4971
）
-
TLR2-dependent inflammatory response to Porphyromonas gingivalis is MyD88 independent, whereas MyD88 is required to clear infection.
Reviewed
Burns E, Eliyahu T, Uematsu S, Akira S, Nussbaum G
Journal of immunology (Baltimore, Md. : 1950)
184
(
3
)
1455
-
62
2010.02（ ISSN:0022-1767
）
-
Endothelial microsomal prostaglandin E synthase-1 exacerbates neuronal loss induced by kainate.
Reviewed
Takemiya T, Matsumura K, Sugiura H, Maehara M, Yasuda S, Uematsu S, Akira S, Yamagata K
Journal of neuroscience research
88
(
2
)
381
-
90
2010.02（ ISSN:0360-4012
）
-
Prostaglandin E(2) exerts homeostatic regulation of pulmonary vascular remodeling in allergic airway inflammation.
Reviewed
Lundequist A, Nallamshetty SN, Xing W, Feng C, Laidlaw TM, Uematsu S, Akira S, Boyce JA
Journal of immunology (Baltimore, Md. : 1950)
184
(
1
)
433
-
41
2010.01（ ISSN:0022-1767
）
-
Microsomal prostaglandin E synthase-1 in both cancer cells and hosts contributes to tumour growth, invasion and metastasis.
Reviewed
Kamei D, Murakami M, Sasaki Y, Nakatani Y, Majima M, Ishikawa Y, Ishii T, Uematsu S, Akira S, Hara S, Kudo I
The Biochemical journal
425
(
2
)
361
-
71
2009.12（ ISSN:0264-6021
）
-
Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis.
Reviewed
Kihara Y, Matsushita T, Kita Y, Uematsu S, Akira S, Kira J, Ishii S, Shimizu T
Proceedings of the National Academy of Sciences of the United States of America
106
(
51
)
21807
-
12
2009.12（ ISSN:0027-8424
）
-
Baculovirus induces type I interferon production through toll-like receptor-dependent and -independent pathways in a cell-type-specific manner.
Reviewed
Abe T, Kaname Y, Wen X, Tani H, Moriishi K, Uematsu S, Takeuchi O, Ishii KJ, Kawai T, Akira S, Matsuura Y
Journal of virology
83
(
15
)
7629
-
40
2009.08（ ISSN:0022-538X
）
-
Downstream signals for MyD88-mediated phagocytosis of Borrelia burgdorferi can be initiated by TRIF and are dependent on PI3K.
Reviewed
Shin OS, Miller LS, Modlin RL, Akira S, Uematsu S, Hu LT
Journal of immunology (Baltimore, Md. : 1950)
183
(
1
)
491
-
8
2009.07（ ISSN:0022-1767
）
-
PolyI:C-induced reduction in uptake of soluble antigen is independent of dendritic cell activation.
Reviewed
Tirapu I, Giquel B, Alexopoulou L, Uematsu S, Flavell R, Akira S, Diebold SS
International immunology
21
(
7
)
871
-
9
2009.07（ ISSN:0953-8178
）
-
NFATc1 mediates Toll-like receptor-independent innate immune responses during Trypanosoma cruzi infection.
Reviewed
Kayama H, Koga R, Atarashi K, Okuyama M, Kimura T, Mak TW, Uematsu S, Akira S, Takayanagi H, Honda K, Yamamoto M, Takeda K
PLoS pathogens
5
(
7
)
e1000514
2009.07（ ISSN:1553-7366
）
-
Direct stimulation of tlr5+/+ CD11c+ cells is necessary for the adjuvant activity of flagellin.
Reviewed
Bates JT, Uematsu S, Akira S, Mizel SB
Journal of immunology (Baltimore, Md. : 1950)
182
(
12
)
7539
-
47
2009.06（ ISSN:0022-1767
）
-
Radioresistant cells expressing TLR5 control the respiratory epithelium's innate immune responses to flagellin.
Reviewed
Janot L, Sirard JC, Secher T, Noulin N, Fick L, Akira S, Uematsu S, Didierlaurent A, Hussell T, Ryffel B, Erard F
European journal of immunology
39
(
6
)
1587
-
96
2009.06（ ISSN:0014-2980
）
-
[TLR5+ DC-mediated immune response to bacterial infection in the intestine].
Reviewed
Uematsu S
Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme
54
(
8 Suppl
)
1020
-
6
2009.06（ ISSN:0039-9450
）
-
Toll-like receptor 3 enhances late-phase reaction of experimental allergic conjunctivitis.
Reviewed
Ueta M, Uematsu S, Akira S, Kinoshita S
The Journal of allergy and clinical immunology
123
(
5
)
1187
-
9
2009.05（ ISSN:0091-6749
）
-
Toll-like receptor 2 deficiency is associated with enhanced severity of group B streptococcal disease.
Reviewed
Puliti M, Uematsu S, Akira S, Bistoni F, Tissi L
Infection and immunity
77
(
4
)
1524
-
31
2009.04（ ISSN:0019-9567
）
-
Pivotal Advance: Toll-like receptor regulation of scavenger receptor-A-mediated phagocytosis.
Reviewed
Amiel E, Alonso A, Uematsu S, Akira S, Poynter ME, Berwin B
Journal of leukocyte biology
85
(
4
)
595
-
605
2009.04（ ISSN:0741-5400
）
-
Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products.
Reviewed
Allard JB, Rinaldi L, Wargo MJ, Allen G, Akira S, Uematsu S, Poynter ME, Hogan DA, Rincon M, Whittaker LA
European journal of immunology
39
(
3
)
776
-
88
2009.03（ ISSN:0014-2980
）
-
Bacterial endotoxin induces the release of high mobility group box 1 via the IFN-beta signaling pathway.
Reviewed
Kim JH, Kim SJ, Lee IS, Lee MS, Uematsu S, Akira S, Oh KI
Journal of immunology (Baltimore, Md. : 1950)
182
(
4
)
2458
-
66
2009.02（ ISSN:0022-1767
）
-
Induction of adaptive immunity by flagellin does not require robust activation of innate immunity.
Reviewed
Sanders CJ, Franchi L, Yarovinsky F, Uematsu S, Akira S, Núñez G, Gewirtz AT
European journal of immunology
39
(
2
)
359
-
71
2009.02（ ISSN:0014-2980
）
-
Immune responses of TLR5(+) lamina propria dendritic cells in enterobacterial infection.
Reviewed
Uematsu S, Akira S
Journal of gastroenterology
44
(
8
)
803
-
11
2009（ ISSN:0944-1174
）
-
Toll-like receptor 2 mediates apolipoprotein CIII-induced monocyte activation.
Reviewed
Kawakami A, Osaka M, Aikawa M, Uematsu S, Akira S, Libby P, Shimokado K, Sacks FM, Yoshida M
Circulation research
103
(
12
)
1402
-
9
2008.12（ ISSN:0009-7330
）
-
MyD88 is required for protection from lethal infection with a mouse-adapted SARS-CoV.
Reviewed
Sheahan T, Morrison TE, Funkhouser W, Uematsu S, Akira S, Baric RS, Heise MT
PLoS pathogens
4
(
12
)
e1000240
2008.12（ ISSN:1553-7366
）
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production.
Reviewed
Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, Omori H, Noda T, Yamamoto N, Komatsu M, Tanaka K, Kawai T, Tsujimura T, Takeuchi O, Yoshimori T, Akira S
Nature
456
(
7219
)
264
-
8
2008.11（ ISSN:0028-0836
）
-
Role of microsomal prostaglandin E synthase-1 (mPGES1)-derived PGE2 in patency of the ductus arteriosus in the mouse.
Reviewed
Baragatti B, Sodini D, Uematsu S, Coceani F
Pediatric research
64
(
5
)
523
-
7
2008.11（ ISSN:0031-3998
）
-
Toll-like receptor ligands synergize through distinct dendritic cell pathways to induce T cell responses: implications for vaccines.
Reviewed
Zhu Q, Egelston C, Vivekanandhan A, Uematsu S, Akira S, Klinman DM, Belyakov IM, Berzofsky JA
Proceedings of the National Academy of Sciences of the United States of America
105
(
42
)
16260
-
5
2008.10（ ISSN:0027-8424
）
-
Evidence for genes in addition to Tlr7 in the Yaa translocation linked with acceleration of systemic lupus erythematosus.
Reviewed
Santiago-Raber ML, Kikuchi S, Borel P, Uematsu S, Akira S, Kotzin BL, Izui S
Journal of immunology (Baltimore, Md. : 1950)
181
(
2
)
1556
-
62
2008.07（ ISSN:0022-1767
）
-
Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5.
Reviewed
Uematsu S, Fujimoto K, Jang MH, Yang BG, Jung YJ, Nishiyama M, Sato S, Tsujimura T, Yamamoto M, Yokota Y, Kiyono H, Miyasaka M, Ishii KJ, Akira S
Nature immunology
9
(
7
)
769
-
76
2008.07（ ISSN:1529-2908
）
-
Distinct roles for MyD88 and Toll-like receptors 2, 5, and 9 in phagocytosis of Borrelia burgdorferi and cytokine induction.
Reviewed
Shin OS, Isberg RR, Akira S, Uematsu S, Behera AK, Hu LT
Infection and immunity
76
(
6
)
2341
-
51
2008.06（ ISSN:0019-9567
）
-
Cutting edge: Overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection.
Reviewed
Zucchini N, Bessou G, Traub S, Robbins SH, Uematsu S, Akira S, Alexopoulou L, Dalod M
Journal of immunology (Baltimore, Md. : 1950)
180
(
9
)
5799
-
803
2008.05（ ISSN:0022-1767
）
-
Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells.
Reviewed
Hirata N, Yanagawa Y, Ebihara T, Seya T, Uematsu S, Akira S, Hayashi F, Iwabuchi K, Onoé K
Molecular immunology
45
(
10
)
2734
-
42
2008.05（ ISSN:0161-5890
）
-
TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity.
Reviewed
Zhang B, Ramesh G, Uematsu S, Akira S, Reeves WB
Journal of the American Society of Nephrology : JASN
19
(
5
)
923
-
32
2008.05（ ISSN:1046-6673
）
-
Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease.
Reviewed
Vijay-Kumar M, Aitken JD, Kumar A, Neish AS, Uematsu S, Akira S, Gewirtz AT
Infection and immunity
76
(
3
)
1276
-
81
2008.03（ ISSN:0019-9567
）
-
Activation of cytosolic phospholipase A2alpha in resident peritoneal macrophages by Listeria monocytogenes involves listeriolysin O and TLR2.
Reviewed
Noor S, Goldfine H, Tucker DE, Suram S, Lenz LL, Akira S, Uematsu S, Girotti M, Bonventre JV, Breuel K, Williams DL, Leslie CC
The Journal of biological chemistry
283
(
8
)
4744
-
55
2008.02（ ISSN:0021-9258
）
-
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines.
Reviewed
Ishii KJ, Kawagoe T, Koyama S, Matsui K, Kumar H, Kawai T, Uematsu S, Takeuchi O, Takeshita F, Coban C, Akira S
Nature
451
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7179
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725
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9
2008.02（ ISSN:0028-0836
）
-
Colonic patches direct the cross-talk between systemic compartments and large intestine independently of innate immunity.
Reviewed
Chang SY, Cha HR, Uematsu S, Akira S, Igarashi O, Kiyono H, Kweon MN
Journal of immunology (Baltimore, Md. : 1950)
180
(
3
)
1609
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18
2008.02（ ISSN:0022-1767
）
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[Innate immunity and tuberculosis].
Reviewed
Uematsu S, Akira S
Kekkaku : [Tuberculosis]
83
(
2
)
101
-
9
2008.02（ ISSN:0022-9776
）
-
Induction of prostaglandin E2 synthesis and microsomal prostaglandin E synthase-1 expression in murine microglia by glioma-derived soluble factors. Laboratory investigation.
Reviewed
Nakano Y, Kuroda E, Kito T, Uematsu S, Akira S, Yokota A, Nishizawa S, Yamashita U
Journal of neurosurgery
108
(
2
)
311
-
9
2008.02（ ISSN:0022-3085
）
-
Association of microsomal prostaglandin E synthase 1 deficiency with impaired fracture healing, but not with bone loss or osteoarthritis, in mouse models of skeletal disorders.
Reviewed
Yamakawa K, Kamekura S, Kawamura N, Saegusa M, Kamei D, Murakami M, Kudo I, Uematsu S, Akira S, Chung UI, Nakamura K, Kawaguchi H
Arthritis and rheumatism
58
(
1
)
172
-
83
2008.01（ ISSN:0004-3591
）
-
Toll-Like receptors (TLRs) and their ligands.
Reviewed
Uematsu S, Akira S
Handbook of experimental pharmacology
(
183
)
1
-
20
2008（ ISSN:0171-2004
）
-
Deletion of TLR5 results in spontaneous colitis in mice.
Reviewed
Vijay-Kumar M, Sanders CJ, Taylor RT, Kumar A, Aitken JD, Sitaraman SV, Neish AS, Uematsu S, Akira S, Williams IR, Gewirtz AT
The Journal of clinical investigation
117
(
12
)
3909
-
21
2007.12（ ISSN:0021-9738
）
-
Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.
Reviewed
Hawn TR, Berrington WR, Smith IA, Uematsu S, Akira S, Aderem A, Smith KD, Skerrett SJ
Journal of immunology (Baltimore, Md. : 1950)
179
(
10
)
6981
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7
2007.11（ ISSN:0022-1767
）
-
The C/EBP beta isoform 34-kDa LAP is responsible for NF-IL-6-mediated gene induction in activated macrophages, but is not essential for intracellular bacteria killing.
Reviewed
Uematsu S, Kaisho T, Tanaka T, Matsumoto M, Yamakami M, Omori H, Yamamoto M, Yoshimori T, Akira S
Journal of immunology (Baltimore, Md. : 1950)
179
(
8
)
5378
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86
2007.10（ ISSN:0022-1767
）
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Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination.
Reviewed
Koyama S, Ishii KJ, Kumar H, Tanimoto T, Coban C, Uematsu S, Kawai T, Akira S
Journal of immunology (Baltimore, Md. : 1950)
179
(
7
)
4711
-
20
2007.10（ ISSN:0022-1767
）
-
Nitrogen dioxide promotes allergic sensitization to inhaled antigen.
Reviewed
Bevelander M, Mayette J, Whittaker LA, Paveglio SA, Jones CC, Robbins J, Hemenway D, Akira S, Uematsu S, Poynter ME
Journal of immunology (Baltimore, Md. : 1950)
179
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6
)
3680
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8
2007.09（ ISSN:0022-1767
）
-
Enhanced TLR-mediated NF-IL6 dependent gene expression by Trib1 deficiency.
Reviewed
Yamamoto M, Uematsu S, Okamoto T, Matsuura Y, Sato S, Kumar H, Satoh T, Saitoh T, Takeda K, Ishii KJ, Takeuchi O, Kawai T, Akira S
The Journal of experimental medicine
204
(
9
)
2233
-
9
2007.09（ ISSN:0022-1007
）
-
Lymphoma immunotherapy with CpG oligodeoxynucleotides requires TLR9 either in the host or in the tumor itself.
Reviewed
Li J, Song W, Czerwinski DK, Varghese B, Uematsu S, Akira S, Krieg AM, Levy R
Journal of immunology (Baltimore, Md. : 1950)
179
(
4
)
2493
-
500
2007.08（ ISSN:0022-1767
）
-
[Toll-like receptor and innate immunity].
Reviewed
Uematsu S, Akira S
Seikagaku. The Journal of Japanese Biochemical Society
79
(
8
)
769
-
76
2007.08（ ISSN:0037-1017
）
-
IL-3 is an important differentiation factor for the development of prostaglandin E2-producing macrophages between C57BL/6 and BALB/c mice.
Reviewed
Kuroda E, Noguchi J, Doi T, Uematsu S, Akira S, Yamashita U
European journal of immunology
37
(
8
)
2185
-
95
2007.08（ ISSN:0014-2980
）
-
Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.
Reviewed
Saha S, Takeshita F, Matsuda T, Jounai N, Kobiyama K, Matsumoto T, Sasaki S, Yoshida A, Xin KQ, Klinman DM, Uematsu S, Ishii KJ, Akira S, Okuda K
Journal of immunology (Baltimore, Md. : 1950)
179
(
2
)
1147
-
54
2007.07（ ISSN:0022-1767
）
-
Endotoxin and cisplatin synergistically induce renal dysfunction and cytokine production in mice.
Reviewed
Ramesh G, Zhang B, Uematsu S, Akira S, Reeves WB
American journal of physiology. Renal physiology
293
(
1
)
F325
-
32
2007.07（ ISSN:1931-857X
）
-
Immunogenicity and protective efficacy offered by a ribosomal-based vaccine from Shigella flexneri 2a.
Reviewed
Shim DH, Chang SY, Park SM, Jang H, Carbis R, Czerkinsky C, Uematsu S, Akira S, Kweon MN
Vaccine
25
(
25
)
4828
-
36
2007.06（ ISSN:0264-410X
）
-
Toll-like receptors and Type I interferons.
Reviewed
Uematsu S, Akira S
The Journal of biological chemistry
282
(
21
)
15319
-
23
2007.05（ ISSN:0021-9258
）
-
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling.
Reviewed
Kawagoe T, Sato S, Jung A, Yamamoto M, Matsui K, Kato H, Uematsu S, Takeuchi O, Akira S
The Journal of experimental medicine
204
(
5
)
1013
-
24
2007.05（ ISSN:0022-1007
）
-
Deficiencies of myeloid differentiation factor 88, Toll-like receptor 2 (TLR2), or TLR4 produce specific defects in macrophage cytokine secretion induced by Helicobacter pylori.
Reviewed
Obonyo M, Sabet M, Cole SP, Ebmeyer J, Uematsu S, Akira S, Guiney DG
Infection and immunity
75
(
5
)
2408
-
14
2007.05（ ISSN:0019-9567
）
-
Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection.
Reviewed
Andersen-Nissen E, Hawn TR, Smith KD, Nachman A, Lampano AE, Uematsu S, Akira S, Aderem A
Journal of immunology (Baltimore, Md. : 1950)
178
(
8
)
4717
-
20
2007.04（ ISSN:0022-1767
）
-
TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses.
Reviewed
Heer AK, Shamshiev A, Donda A, Uematsu S, Akira S, Kopf M, Marsland BJ
Journal of immunology (Baltimore, Md. : 1950)
178
(
4
)
2182
-
91
2007.02（ ISSN:0022-1767
）
-
Pathological role of Toll-like receptor signaling in cerebral malaria.
Reviewed
Coban C, Ishii KJ, Uematsu S, Arisue N, Sato S, Yamamoto M, Kawai T, Takeuchi O, Hisaeda H, Horii T, Akira S
International immunology
19
(
1
)
67
-
79
2007.01（ ISSN:0953-8178
）
-
VP1686, a Vibrio type III secretion protein, induces toll-like receptor-independent apoptosis in macrophage through NF-kappaB inhibition.
Reviewed
Bhattacharjee RN, Park KS, Kumagai Y, Okada K, Yamamoto M, Uematsu S, Matsui K, Kumar H, Kawai T, Iida T, Honda T, Takeuchi O, Akira S
The Journal of biological chemistry
281
(
48
)
36897
-
904
2006.12（ ISSN:0021-9258
）
-
Cutting Edge: Pivotal function of Ubc13 in thymocyte TCR signaling.
Reviewed
Yamamoto M, Sato S, Saitoh T, Sakurai H, Uematsu S, Kawai T, Ishii KJ, Takeuchi O, Akira S
Journal of immunology (Baltimore, Md. : 1950)
177
(
11
)
7520
-
4
2006.12（ ISSN:0022-1767
）
-
Cutting edge: Role of TANK-binding kinase 1 and inducible IkappaB kinase in IFN responses against viruses in innate immune cells.
Reviewed
Matsui K, Kumagai Y, Kato H, Sato S, Kawagoe T, Uematsu S, Takeuchi O, Akira S
Journal of immunology (Baltimore, Md. : 1950)
177
(
9
)
5785
-
9
2006.11（ ISSN:0022-1767
）
-
Intact TRL 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10.
Reviewed
Wuest T, Austin BA, Uematsu S, Thapa M, Akira S, Carr DJ
Journal of neuroimmunology
179
(
1-2
)
46
-
52
2006.10（ ISSN:0165-5728
）
-
Toll-like receptors and innate immunity.
Reviewed
Uematsu S, Akira S
Journal of molecular medicine (Berlin, Germany)
84
(
9
)
712
-
25
2006.09（ ISSN:0946-2716
）
-
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling.
Reviewed
Yamamoto M, Okamoto T, Takeda K, Sato S, Sanjo H, Uematsu S, Saitoh T, Yamamoto N, Sakurai H, Ishii KJ, Yamaoka S, Kawai T, Matsuura Y, Takeuchi O, Akira S
Nature immunology
7
(
9
)
962
-
70
2006.09（ ISSN:1529-2908
）
-
Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.
Reviewed
Kim L, Butcher BA, Lee CW, Uematsu S, Akira S, Denkers EY
Journal of immunology (Baltimore, Md. : 1950)
177
(
4
)
2584
-
91
2006.08（ ISSN:0022-1767
）
-
Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation.
Reviewed
Inada M, Matsumoto C, Uematsu S, Akira S, Miyaura C
Journal of immunology (Baltimore, Md. : 1950)
177
(
3
)
1879
-
85
2006.08（ ISSN:0022-1767
）
-
Microsomal prostaglandin E synthase-1 is a critical factor of stroke-reperfusion injury.
Reviewed
Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y
Proceedings of the National Academy of Sciences of the United States of America
103
(
31
)
11790
-
5
2006.08（ ISSN:0027-8424
）
-
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.
Reviewed
Shirakawa K, Maeda S, Gotoh T, Hayashi M, Shinomiya K, Ehata S, Nishimura R, Mori M, Onozaki K, Hayashi H, Uematsu S, Akira S, Ogata E, Miyazono K, Imamura T
Molecular and cellular biology
26
(
16
)
6105
-
16
2006.08（ ISSN:0270-7306
）
-
Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.
Reviewed
Uematsu S, Jang MH, Chevrier N, Guo Z, Kumagai Y, Yamamoto M, Kato H, Sougawa N, Matsui H, Kuwata H, Hemmi H, Coban C, Kawai T, Ishii KJ, Takeuchi O, Miyasaka M, Takeda K, Akira S
Nature immunology
7
(
8
)
868
-
74
2006.08（ ISSN:1529-2908
）
-
Essential role of IPS-1 in innate immune responses against RNA viruses.
Reviewed
Kumar H, Kawai T, Kato H, Sato S, Takahashi K, Coban C, Yamamoto M, Uematsu S, Ishii KJ, Takeuchi O, Akira S
The Journal of experimental medicine
203
(
7
)
1795
-
803
2006.07（ ISSN:0022-1007
）
-
Identification of a TLR-independent pathway for Borrelia burgdorferi-induced expression of matrix metalloproteinases and inflammatory mediators through binding to integrin alpha 3 beta 1.
Reviewed
Behera AK, Hildebrand E, Uematsu S, Akira S, Coburn J, Hu LT
Journal of immunology (Baltimore, Md. : 1950)
177
(
1
)
657
-
64
2006.07（ ISSN:0022-1767
）
-
TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation.
Reviewed
Cottalorda A, Verschelde C, Marçais A, Tomkowiak M, Musette P, Uematsu S, Akira S, Marvel J, Bonnefoy-Berard N
European journal of immunology
36
(
7
)
1684
-
93
2006.07（ ISSN:0014-2980
）
-
Activation of smooth muscle and myenteric plexus cells of jejunum via Toll-like receptor 4.
Reviewed
Rumio C, Besusso D, Arnaboldi F, Palazzo M, Selleri S, Gariboldi S, Akira S, Uematsu S, Bignami P, Ceriani V, Ménard S, Balsari A
Journal of cellular physiology
208
(
1
)
47
-
54
2006.07（ ISSN:0021-9541
）
-
[Innate immunity and toll-like receptor].
Reviewed
Uematsu S, Akira S
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
95
(
6
)
1115
-
21
2006.06（ ISSN:0021-5384
）
-
[Innate immune recognition of viral infection].
Reviewed
Uematsu S, Akira S
Uirusu
56
(
1
)
1
-
8
2006.06（ ISSN:0042-6857
）
-
Oral and intraperitoneal administration of phosphorothioate oligodeoxynucleotides leads to control of Cryptosporidium parvum infection in neonatal mice.
Reviewed
Barrier M, Lacroix-Lamandé S, Mancassola R, Auray G, Bernardet N, Chaussé AM, Uematsu S, Akira S, Laurent F
The Journal of infectious diseases
193
(
10
)
1400
-
7
2006.05（ ISSN:0022-1899
）
-
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses.
Reviewed
Kato H, Takeuchi O, Sato S, Yoneyama M, Yamamoto M, Matsui K, Uematsu S, Jung A, Kawai T, Ishii KJ, Yamaguchi O, Otsu K, Tsujimura T, Koh CS, Reis e Sousa C, Matsuura Y, Fujita T, Akira S
Nature
441
(
7089
)
101
-
5
2006.05（ ISSN:0028-0836
）
-
Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor.
Reviewed
Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC
The Journal of biological chemistry
281
(
9
)
5506
-
14
2006.03（ ISSN:0021-9258
）
-
The role of Toll-like receptors in immune disorders.
Reviewed
Uematsu S, Akira S
Expert opinion on biological therapy
6
(
3
)
203
-
14
2006.03（ ISSN:1471-2598
）
-
MyD88 deficiency results in tissue-specific changes in cytokine induction and inflammation in interleukin-18-independent mice infected with Borrelia burgdorferi.
Reviewed
Behera AK, Hildebrand E, Bronson RT, Perides G, Uematsu S, Akira S, Hu LT
Infection and immunity
74
(
3
)
1462
-
70
2006.03（ ISSN:0019-9567
）
-
Pathogen recognition and innate immunity.
Reviewed
Akira S, Uematsu S, Takeuchi O
Cell
124
(
4
)
783
-
801
2006.02（ ISSN:0092-8674
）
-
A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.
Reviewed
Ishii KJ, Coban C, Kato H, Takahashi K, Torii Y, Takeshita F, Ludwig H, Sutter G, Suzuki K, Hemmi H, Sato S, Yamamoto M, Uematsu S, Kawai T, Takeuchi O, Akira S
Nature immunology
7
(
1
)
40
-
8
2006.01（ ISSN:1529-2908
）
-
'Toll' gates for future immunotherapy.
Reviewed
Ishii KJ, Uematsu S, Akira S
Current pharmaceutical design
12
(
32
)
4135
-
42
2006（ ISSN:1381-6128
）
-
Escherichia coli verotoxin 1 mediates apoptosis in human HCT116 colon cancer cells by inducing overexpression of the GADD family of genes and S phase arrest.
Reviewed
Bhattacharjee RN, Park KS, Uematsu S, Okada K, Hoshino K, Takeda K, Takeuchi O, Akira S, Iida T, Honda T
FEBS letters
579
(
29
)
6604
-
10
2005.12（ ISSN:0014-5793
）
-
Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus.
Reviewed
Barrat FJ, Meeker T, Gregorio J, Chan JH, Uematsu S, Akira S, Chang B, Duramad O, Coffman RL
The Journal of experimental medicine
202
(
8
)
1131
-
9
2005.10（ ISSN:0022-1007
）
-
Natural killer cell and macrophage cooperation in MyD88-dependent innate responses to Plasmodium falciparum.
Reviewed
Baratin M, Roetynck S, Lépolard C, Falk C, Sawadogo S, Uematsu S, Akira S, Ryffel B, Tiraby JG, Alexopoulou L, Kirschning CJ, Gysin J, Vivier E, Ugolini S
Proceedings of the National Academy of Sciences of the United States of America
102
(
41
)
14747
-
52
2005.10（ ISSN:0027-8424
）
-
Microarray analysis identifies apoptosis regulatory gene expression in HCT116 cells infected with thermostable direct hemolysin-deletion mutant of Vibrio parahaemolyticus.
Reviewed
Bhattacharjee RN, Park KS, Okada K, Kumagai Y, Uematsu S, Takeuchi O, Akira S, Iida T, Honda T
Biochemical and biophysical research communications
335
(
2
)
328
-
34
2005.09（ ISSN:0006-291X
）
-
Microglia-specific expression of microsomal prostaglandin E2 synthase-1 contributes to lipopolysaccharide-induced prostaglandin E2 production.
Reviewed
Ikeda-Matsuo Y, Ikegaya Y, Matsuki N, Uematsu S, Akira S, Sasaki Y
Journal of neurochemistry
94
(
6
)
1546
-
58
2005.09（ ISSN:0022-3042
）
-
Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Reviewed
de Jonge WJ, van der Zanden EP, The FO, Bijlsma MF, van Westerloo DJ, Bennink RJ, Berthoud HR, Uematsu S, Akira S, van den Wijngaard RM, Boeckxstaens GE
Nature immunology
6
(
8
)
844
-
51
2005.08（ ISSN:1529-2908
）
-
Cell type-specific involvement of RIG-I in antiviral response.
Reviewed
Kato H, Sato S, Yoneyama M, Yamamoto M, Uematsu S, Matsui K, Tsujimura T, Takeda K, Fujita T, Takeuchi O, Akira S
Immunity
23
(
1
)
19
-
28
2005.07（ ISSN:1074-7613
）
-
B lymphocyte activation by human papillomavirus-like particles directly induces Ig class switch recombination via TLR4-MyD88.
Reviewed
Yang R, Murillo FM, Delannoy MJ, Blosser RL, Yutzy WH 4th, Uematsu S, Takeda K, Akira S, Viscidi RP, Roden RB
Journal of immunology (Baltimore, Md. : 1950)
174
(
12
)
7912
-
9
2005.06（ ISSN:0022-1767
）
-
Dendritic cell maturation induced by muramyl dipeptide (MDP) derivatives: monoacylated MDP confers TLR2/TLR4 activation.
Reviewed
Uehori J, Fukase K, Akazawa T, Uematsu S, Akira S, Funami K, Shingai M, Matsumoto M, Azuma I, Toyoshima K, Kusumoto S, Seya T
Journal of immunology (Baltimore, Md. : 1950)
174
(
11
)
7096
-
103
2005.06（ ISSN:0022-1767
）
-
Papillomavirus capsid mutation to escape dendritic cell-dependent innate immunity in cervical cancer.
Reviewed
Yang R, Wheeler CM, Chen X, Uematsu S, Takeda K, Akira S, Pastrana DV, Viscidi RP, Roden RB
Journal of virology
79
(
11
)
6741
-
50
2005.06（ ISSN:0022-538X
）
-
Role of lipoteichoic acid in the phagocyte response to group B streptococcus.
Reviewed
Henneke P, Morath S, Uematsu S, Weichert S, Pfitzenmaier M, Takeuchi O, Müller A, Poyart C, Akira S, Berner R, Teti G, Geyer A, Hartung T, Trieu-Cuot P, Kasper DL, Golenbock DT
Journal of immunology (Baltimore, Md. : 1950)
174
(
10
)
6449
-
55
2005.05（ ISSN:0022-1767
）
-
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction.
Reviewed
Uematsu S, Sato S, Yamamoto M, Hirotani T, Kato H, Takeshita F, Matsuda M, Coban C, Ishii KJ, Kawai T, Takeuchi O, Akira S
The Journal of experimental medicine
201
(
6
)
915
-
23
2005.03（ ISSN:0022-1007
）
-
Regulation of lipopolysaccharide-inducible genes by MyD88 and Toll/IL-1 domain containing adaptor inducing IFN-beta.
Reviewed
Hirotani T, Yamamoto M, Kumagai Y, Uematsu S, Kawase I, Takeuchi O, Akira S
Biochemical and biophysical research communications
328
(
2
)
383
-
92
2005.03（ ISSN:0006-291X
）
-
Induction of proinflammatory responses in macrophages by the glycosylphosphatidylinositols of Plasmodium falciparum: cell signaling receptors, glycosylphosphatidylinositol (GPI) structural requirement, and regulation of GPI activity.
Reviewed
Krishnegowda G, Hajjar AM, Zhu J, Douglass EJ, Uematsu S, Akira S, Woods AS, Gowda DC
The Journal of biological chemistry
280
(
9
)
8606
-
16
2005.03（ ISSN:0021-9258
）
-
Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.
Reviewed
Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G
Nature medicine
11
(
3
)
263
-
70
2005.03（ ISSN:1078-8956
）
-
Nonredundant roles of Sema4A in the immune system: defective T cell priming and Th1/Th2 regulation in Sema4A-deficient mice.
Reviewed
Kumanogoh A, Shikina T, Suzuki K, Uematsu S, Yukawa K, Kashiwamura S, Tsutsui H, Yamamoto M, Takamatsu H, Ko-Mitamura EP, Takegahara N, Marukawa S, Ishida I, Morishita H, Prasad DV, Tamura M, Mizui M, Toyofuku T, Akira S, Takeda K, Okabe M, Kikutani H
Immunity
22
(
3
)
305
-
16
2005.03（ ISSN:1074-7613
）
-
[Role of toll-like receptor in immunological defence mechanism ].
Reviewed
Uematsu S, Akira S
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine
94
(
2
)
355
-
61
2005.02（ ISSN:0021-5384
）
-
Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune disease.
Reviewed
Lang KS, Recher M, Junt T, Navarini AA, Harris NL, Freigang S, Odermatt B, Conrad C, Ittner LM, Bauer S, Luther SA, Uematsu S, Akira S, Hengartner H, Zinkernagel RM
Nature medicine
11
(
2
)
138
-
45
2005.02（ ISSN:1078-8956
）
-
Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin.
Reviewed
Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, Yamamoto M, Takeuchi O, Itagaki S, Kumar N, Horii T, Akira S
The Journal of experimental medicine
201
(
1
)
19
-
25
2005.01（ ISSN:0022-1007
）
