Updated on 2024/04/23

写真a

 
TATEKAWA Hiroyuki
 
Organization
Graduate School of Medicine Department of Clinical Medical Science Lecturer
School of Medicine Department of Medical Science
Title
Lecturer
Affiliation
Institute of Medicine

Position

  • Graduate School of Medicine Department of Clinical Medical Science 

    Lecturer  2022.04 - Now

  • School of Medicine Department of Medical Science 

    Lecturer  2022.04 - Now

Degree

  • Doctor of Philosophy (Medical Science) （ Osaka City University ）

  • Medical Doctor （ Kyoto Prefectural University of Medicine ）

Research Areas

  • Life Science / Radiological sciences

Research Interests

  • Brain tumor

  • demyelinating disease

  • epilepsy

  • 認知症

Research subject summary

  • Brain tumor
    Demyelinating disease
    Epilepsy

Research Career

  • FDGPETとてんかん

    Individual

    2018.09 - 2021.03 

  • アミノ酸PETと脳腫瘍

    Individual

    2018.09 - 2021.03 

  • 多発性硬化症と視神経脊髄炎関連疾患

    Individual

    2014.04 - 2018.03 

Professional Memberships

  • 日本核医学会

      Domestic

  • Radiological Society of North America

      Overseas

  • 日本神経放射線学会

      Domestic

  • 日本磁気共鳴学会

      Domestic

  • 日本インターベンショナルラジオロジー学会

      Domestic

  • 日本放射線学会

      Domestic

▼display all

Committee Memberships (off-campus)

  • 代議員   日本磁気共鳴学会  

Awards

  • JJR優秀論文賞最優秀賞

    2024.04   日本医学放射線学会  

  • JJR Excellent Reviewer Award

    2024.04  

  • Alavi-Mandell Award

    2022   Society of Nuclear Medicine and Molecular Imaging  

  • 大阪市医学会賞

    2019  

  • Wagner-Torizuka Fellowship

    2019  

Job Career (off-campus)

  • University of California, Los Angeles

    2018.09 - 2021.03

  • 京都市立病院   初期臨床研修医・放射線科専攻医

    2008.04 - 2013.03

Education

  • Osaka City University   Doctor's Course   Graduated/Completed

    2014.04 - 2018.03

  • Kyoto Prefectural University of Medicine     Graduated/Completed

    2002.04 - 2008.03

Papers

  • 特集 頭部のcommon diseaseにみる非典型的画像所見 脱髄性疾患

    大浦 達史, 立川 裕之, 三木 幸雄

    画像診断   44 ( 5 )   443 - 451   2024.03（ ISSN:02850524 ）

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  • Evaluation of cranial nerve involvement in chordomas and chondrosarcomas: a retrospective imaging study.

    Oura T, Shimono T, Horiuchi D, Goto T, Takita H, Tsukamoto T, Tatekawa H, Ueda D, Matsushita S, Mitsuyama Y, Atsukawa N, Miki Y

    Neuroradiology   2024.02（ ISSN:0028-3940 ）

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  • Deep learning-based diffusion tensor image generation model: a proof-of-concept study.

    Tatekawa H, Ueda D, Takita H, Matsumoto T, Walston SL, Mitsuyama Y, Horiuchi D, Matsushita S, Oura T, Tomita Y, Tsukamoto T, Shimono T, Miki Y

    Scientific reports   14 ( 1 )   2911   2024.02

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  • MRIとアミロイド関連画像異常(ARIA)

    堀内 大右, 立川 裕之, 三木 幸雄

    医学のあゆみ   287 ( 13 )   978 - 984   2023.12（ ISSN:00392359 ）

  • 第5土曜特集 アルツハイマー病--研究と治療の最前線 画像･AI MRIとアミロイド関連画像異常(ARIA)

    堀内 大右, 立川 裕之, 三木 幸雄

    医学のあゆみ   287 ( 13 )   978 - 984   2023.12（ ISSN:00392359 ）

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  • Accuracy of ChatGPT generated diagnosis from patient's medical history and imaging findings in neuroradiology cases.

    Horiuchi D, Tatekawa H, Shimono T, Walston SL, Takita H, Matsushita S, Oura T, Mitsuyama Y, Miki Y, Ueda D

    Neuroradiology   66 ( 1 )   73 - 79   2023.11（ ISSN:0028-3940 ）

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  • Bridging Language and Stylistic Barriers in Interventional Radiology Standardized Reporting: Enhancing Translation and Structure using ChatGPT-4.

    Sasaki F, Tatekawa H, Mitsuyama Y, Kageyama K, Jogo A, Yamamoto A, Miki Y, Ueda D

    Journal of vascular and interventional radiology : JVIR   35 ( 3 )   472 - 475.e1   2023.11（ ISSN:1051-0443 ）

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  • 症例 傍咽頭間隙から発生した小児の脱分化型脂肪肉腫の1例

    田中 里可子, 立川 裕之, 山本 祐輝, 大石 賢弥, 塚本 太朗, 松野 舞衣, 角南 貴司子, 三木 幸雄

    臨床放射線   68 ( 10 )   987 - 991   2023.10（ ISSN:00099252 ）

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  • 傍咽頭間隙から発生した小児の脱分化型脂肪肉腫の1例

    田中 里可子, 立川 裕之, 山本 祐輝, 大石 賢弥, 塚本 太朗, 松野 舞衣, 角南 貴司子, 三木 幸雄

    臨床放射線   68 ( 10 )   987 - 991   2023.10（ ISSN:0009-9252 ）

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    症例は12歳男児で、左頬部腫脹を主訴とした。穿刺吸引細胞診や生検では診断できず、造影CT・MRI所見より多形腺腫、神経鞘腫、横紋筋肉腫、炎症性筋繊維芽細胞腫を疑った。腫瘤摘出術を行い、免疫組織化学染色でCDK4およびMDM2が陽性であったことより脱分化型脂肪肉腫と診断した。術後5年現在、再発や転移は認めない。本例は傍咽頭間隙から発生した脱分化型脂肪肉腫で、脂肪成分が僅かであったため画像所見で診断できず、免疫組織化学染色により診断を得られた。

  • Chest radiography as a biomarker of ageing: artificial intelligence-based, multi-institutional model development and validation in Japan.

    Mitsuyama Y, Matsumoto T, Tatekawa H, Walston SL, Kimura T, Yamamoto A, Watanabe T, Miki Y, Ueda D

    The lancet. Healthy longevity   4 ( 9 )   e478 - e486   2023.08

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  • AI-based Virtual Synthesis of Methionine PET from Contrast-enhanced MRI: Development and External Validation Study.

    Takita H, Matsumoto T, Tatekawa H, Katayama Y, Nakajo K, Uda T, Mitsuyama Y, Walston SL, Miki Y, Ueda D

    Radiology   308 ( 2 )   e223016   2023.08（ ISSN:0033-8419 ）

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  • MR findings of the inflammatory demyelinating diseases of the central nervous system

    M.D. Ph.D. Tatekawa Hiroyuki, M.D. Ph.D. Miki Yukio

    Rinsho Shinkeigaku   63 ( 7 )   425 - 432   2023.07（ ISSN:0009-918X ）

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    <p>When demyelinating disease of the central nervous system is suspected, MR examination has mainly three roles: diagnosis, imaging biomarkers, and early detection of adverse effects from therapeutic agents. Because the location, size, shape, distribution, signal intensity, and contrast pattern of the brain lesions on MRI vary depending on the demyelinating diseases, careful attentions are required to assess the differential diagnosis and activity. It is necessary to be familiar with not only typical imaging findings but also atypical findings of demyelinating disease since minor neurological findings and nonspecific brain lesions may lead to misdiagnosis of demyelinating disease. This article reviewed the characteristics of MRI findings and showed recent topics of the demyelinating diseases.</p>

    DOI： 10.5692/clinicalneurol.cn-001855

    PubMed

  • The Association of Metabolic Brain MRI, Amyloid PET, and Clinical Factors: A Study of Alzheimer's Disease and Normal Controls From the Open Access Series of Imaging Studies Dataset.

    Matsushita S, Tatekawa H, Ueda D, Takita H, Horiuchi D, Tsukamoto T, Shimono T, Miki Y

    Journal of magnetic resonance imaging : JMRI   59 ( 4 )   1341 - 1348   2023.07（ ISSN:1053-1807 ）

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  • ChatGPT's Diagnostic Performance from Patient History and Imaging Findings on the Diagnosis Please Quizzes.

    Ueda D, Mitsuyama Y, Takita H, Horiuchi D, Walston SL, Tatekawa H, Miki Y

    Radiology   308 ( 1 )   e231040   2023.07（ ISSN:0033-8419 ）

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  • Amygdala subfield and prefrontal cortex abnormalities in patients with functional seizures.

    Nasrullah N, Kerr WT, Stern JM, Wang Y, Tatekawa H, Lee JK, Karimi AH, Sreenivasan SS, Engel J Jr, Eliashiv DE, Feusner JD, Salamon N, Savic I

    Epilepsy & behavior : E&B   145   109278   2023.06（ ISSN:1525-5050 ）

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  • Reply to the letter to the editor: Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index calculated by manual and automated methods.

    Tatekawa H, Matsushita S, Miki Y

    Japanese journal of radiology   41 ( 9 )   1035 - 1036   2023.06（ ISSN:1867-1071 ）

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  • Improved reproducibility of diffusion tensor image analysis along the perivascular space(DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset(タイトル和訳中)

    Tatekawa Hiroyuki, Matsushita Shu, Ueda Daiju, Takita Hirotaka, Horiuchi Daisuke, Atsukawa Natsuko, Morishita Yuka, Tsukamoto Taro, Shimono Taro, Miki Yukio

    Japanese Journal of Radiology   41 ( 4 )   393 - 400   2023.04（ ISSN:1867-1071 ）

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    拡散テンソルイメージング(DTI)データの画像再構成により、analysis along the perivascular space(ALPS) indexにおいて再現性の改善を試みた。なお、本報では脳MRI画像データが登録されたオープンデータベースOASIS-3データセットから、認知機能が正常な234名(男性123名、女性111名、年齢42～92歳)の画像データを用いて実施した。また、DTIのベクトル情報を他の血管周囲腔に位置合わせする画像再構成技術を適用し、元データのALPS indexと再構成したALPS indexを新たに求め、再構成処理したdiffusivity mapを作成した。これらデータ間を比較した結果、再構成処理したALPS indexの変動は元データのALPS indexに比べ有意に小さく、再構成技術により、頭部回転を有する被験者でも良好ないし優れたALPS index数値の再現性が得られた。特にx軸で頭部回転が観察された被験者では、元データALPS indexと再構成したALPS indexを比較したBland-Altmanプロットにより、広範囲に及ぶ95%一致限界が認められたことから、x軸の頭部回転はALPS indexの算出に著しく影響を及ぼすことが示唆された。以上より、本法による再構成技術を適用したDTI-ALPS index算出によりALPSの再現性が改善され、再構成処理したdiffusivity mapも作成可能となった。

  • Brain temperature remains stable during the day: a study of diffusion-weighted imaging thermometry in healthy individuals.

    Horiuchi D, Shimono T, Tatekawa H, Tsukamoto T, Takita H, Matsushita S, Miki Y

    Neuroradiology   65 ( 8 )   1239 - 1246   2023.03（ ISSN:0028-3940 ）

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  • Improved reproducibility of diffusion tensor image analysis along the perivascular space (DTI-ALPS) index: an analysis of reorientation technique of the OASIS-3 dataset.

    Tatekawa H, Matsushita S, Ueda D, Takita H, Horiuchi D, Atsukawa N, Morishita Y, Tsukamoto T, Shimono T, Miki Y

    Japanese journal of radiology   41 ( 4 )   393 - 400   2022.12（ ISSN:1867-1071 ）

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  • Clinical MRI morphological analysis of functional seizures compared to seizure-naïve and psychiatric controls.

    Kerr WT, Tatekawa H, Lee JK, Karimi AH, Sreenivasan SS, O'Neill J, Smith JM, Hickman LB, Savic I, Nasrullah N, Espinoza R, Narr K, Salamon N, Beimer NJ, Hadjiiski LM, Eliashiv DS, Stacey WC, Engel J Jr, Feusner JD, Stern JM

    Epilepsy & behavior : E&B   134   108858   2022.08（ ISSN:1525-5050 ）

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  • Incidence, molecular characteristics, and imaging features of "clinically-defined pseudoprogression" in newly diagnosed glioblastoma treated with chemoradiation.

    Hagiwara A, Schlossman J, Shabani S, Raymond C, Tatekawa H, Abrey LE, Garcia J, Chinot O, Saran F, Nishikawa R, Henriksson R, Mason WP, Wick W, Cloughesy TF, Ellingson BM

    Journal of neuro-oncology   159 ( 3 )   509 - 518   2022.07（ ISSN:0167-594X ）

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  • Visual and quantitative evaluation of microcalcifications in mammograms with deep learning-based super-resolution.

    Honjo T, Ueda D, Katayama Y, Shimazaki A, Jogo A, Kageyama K, Murai K, Tatekawa H, Fukumoto S, Yamamoto A, Miki Y

    European journal of radiology   154   110433   2022.07（ ISSN:0720-048X ）

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  • Frequency and imaging features of the adjacent osseous changes of salivary gland carcinomas in the head and neck region.

    Horiuchi D, Shimono T, Tatekawa H, Tsukamoto T, Takita H, Okazaki M, Miki Y

    Neuroradiology   64 ( 9 )   1869 - 1877   2022.05（ ISSN:0028-3940 ）

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  • Correlation between Phase-Difference-Enhanced MR Imaging and Amyloid Positron Emission Tomography: A Study on Alzheimer’s Disease Patients and Normal Controls

    Takita Hirotaka, Doishita Satoshi, Yoneda Tetsuya, Tatekawa Hiroyuki, Abe Takato, Itoh Yoshiaki, Horiuchi Daisuke, Tsukamoto Taro, Shimono Taro, Miki Yukio

    Magnetic Resonance in Medical Sciences   advpub ( 0 )   67 - 78   2022.01（ ISSN:1347-3182 ）

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    <p>Purpose: While amyloid-β deposition in the cerebral cortex for Alzheimer’s disease (AD) is often evaluated by amyloid positron emission tomography (PET), amyloid-β-related iron can be detected using phase difference enhanced (PADRE) imaging; however, no study has validated the association between PADRE imaging and amyloid PET. This study investigated whether the degree of hypointense areas on PADRE imaging correlated with the uptake of amyloid PET.</p><p>Methods: PADRE imaging and amyloid PET were performed in 8 patients with AD and 10 age-matched normal controls. ROIs in the cuneus, precuneus, superior frontal gyrus (SFG), and superior temporal gyrus (STG) were automatically segmented. The degree of hypointense areas on PADRE imaging in each ROI was evaluated using 4-point scaling of visual assessment or volumetric semiquantitative assessment (the percentage of hypointense volume within each ROI). The mean standardized uptake value ratio (SUVR) of amyloid PET in each ROI was also calculated. The Spearman’s correlation coefficient between the 4-point scale of PADRE imaging and SUVR of amyloid PET or between the semiquantitative hypointense volume percentage and SUVR in each ROI was evaluated.</p><p>Results: In the precuneus, a significant positive correlation was identified between the 4-point scale of PADRE imaging and SUVR of amyloid PET (Rs = 0.5; <i>P</i> = 0.034) in all subjects. In the cuneus, a significant positive correlation was identified between the semiquantitative volume percentage of PADRE imaging and SUVR of amyloid PET (Rs = 0.55; <i>P</i> = 0.02) in all subjects.</p><p>Conclusion: Amyloid-β-enhancing PADRE imaging can be used to predict the SUVR of amyloid PET, especially in the cuneus and precuneus, and may have the potential to be used for diagnosing AD by detecting amyloid deposition.</p>

    DOI： 10.2463/mrms.mp.2021-0123

    PubMed

    CiNii Article

  • Visualization of tumor heterogeneity and prediction of isocitrate dehydrogenase mutation status for human gliomas using multiparametric physiologic and metabolic MRI.

    Hagiwara A, Tatekawa H, Yao J, Raymond C, Everson R, Patel K, Mareninov S, Yong WH, Salamon N, Pope WB, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM

    Scientific reports   12 ( 1 )   1078   2022.01

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  • Development and validation of a deep learning model for detection of breast cancers in mammography from multi-institutional datasets.

    Ueda D, Yamamoto A, Onoda N, Takashima T, Noda S, Kashiwagi S, Morisaki T, Fukumoto S, Shiba M, Morimura M, Shimono T, Kageyama K, Tatekawa H, Murai K, Honjo T, Shimazaki A, Kabata D, Miki Y

    PloS one   17 ( 3 )   e0265751   2022

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  • 生物学的残存腫瘍量がより多いIDH野生型びまん性グリオーマは予後不良である(Worse prognosis for IDH wild-type diffuse gliomas with larger residual biological tumor burden)

    Tatekawa Hiroyuki, Uetani Hiroyuki, Hagiwara Akifumi, Bahri Shadfar, Raymond Catalina, Lai Albert, Cloughesy Timothy F., Nghiemphu Phioanh L., Liau Linda M., Pope Whitney B., Salamon Noriko, Ellingson Benjamin M.

    Annals of Nuclear Medicine   35 ( 9 )   1022 - 1029   2021.09（ ISSN:0914-7187 ）

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    イソクエン酸デヒドロゲナーゼ(IDH)野生型びまん性グリオーマ患者の腫瘍量と予後(生存率)との関連について、後方視的に検討した。調査対象者は、未治療のIDH野生型びまん性グリオーマ患者34例(男性21例、女性13例、平均年齢61.0±10.8歳、WHOグレードIIが6例、IIIが15例、IVが13例)とし、術前画像で観察された腫瘍内関心領域(ROI)内の造影効果部分(CE)T1WI像でのCE体積、FLAIR高信号体積、3,4-dihydroxy-6-[18F]-fluoro-L-phenylalanine(FDOPA)高代謝活性領域の体積を調べ、切除後のROIを算出し、各々の残存数値を求めた。その結果、残存CE体積は全生存率(OS)と有意な関連性が認められたが、腫瘍グレード調整後には、これらの関連性はみられなかった。しかし、残存FDOPA高代謝活性領域の体積では回帰モデルとの良好な一致が得られ、腫瘍グレード調整後においても、OSとの有意な関連性が認められた。これらの所見から、FLAIR高信号領域での体積はOSとの有意な相関性はみられないが、残存FDOPA高代謝活性領域での腫瘍量からは、腫瘍グレードに関係なく、IDH野生型びまん性グリオーマ患者のOS予測可能で、高代謝活性CE領域の切除により、予後の改善が期待されることが示唆された。

  • A minority of patients with functional seizures have abnormalities on neuroimaging.

    Kerr WT, Lee JK, Karimi AH, Tatekawa H, Hickman LB, Connerney M, Sreenivasan SS, Dubey I, Allas CH, Smith JM, Savic I, Silverman DHS, Hadjiiski LM, Beimer NJ, Stacey WC, Cohen MS, Engel J Jr, Feusner JD, Salamon N, Stern JM

    Journal of the neurological sciences   427   117548   2021.06（ ISSN:0022-510X ）

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  • Worse prognosis for IDH wild-type diffuse gliomas with larger residual biological tumor burden.

    Tatekawa H, Uetani H, Hagiwara A, Bahri S, Raymond C, Lai A, Cloughesy TF, Nghiemphu PL, Liau LM, Pope WB, Salamon N, Ellingson BM

    Annals of nuclear medicine   35 ( 9 )   1022 - 1029   2021.06（ ISSN:0914-7187 ）

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  • Association of hypometabolic extension of 18F-FDG PET with diffusion tensor imaging indices in mesial temporal lobe epilepsy with hippocampal sclerosis.

    Hiroyuki Tatekawa, Hiroyuki Uetani, Akifumi Hagiwara, Masatoshi Hotta, John M Stern, Jerome Engel Jr, Noriko Salamon

    Seizure   88   130 - 137   2021.04（ ISSN:1059-1311 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    PURPOSE: To assess the association between hypometabolic extension of 18F-fluorodeoxyglucose positron emission tomography and diffusion tensor imaging indices, including mean diffusivity (MD) and fractional anisotropy (FA), in hippocampal sclerosis (HS). METHODS: Thirty-six unilateral HS were retrospectively selected and stratified into two groups: broad and localized hypometabolic groups (hypometabolism beyond [n = 26] and within the temporal lobe [n = 10]). Forty-one pairs of gray matter (GM) regions of interest (ROIs) were segmented using FreeSurfer software. The GM ROIs were applied to MD maps, and median MD values within each ROI were compared between hemispheres ipsilateral and contralateral to HS using a mixed effect model. Tract-Based Spatial Statistics (TBSS) was used to evaluate FA of white matter (WM) tracts between hemispheres ipsilateral and contralateral to HS. Disease laterality was controlled for. RESULTS: The MD values in the thalamus, caudate, hippocampus, amygdala, superior frontal gyrus, middle and inferior temporal gyrus, temporal pole, and isthmus cingulate gyrus were significantly higher in the HS side than the contralateral side for the broad hypometabolic group. Those in the amygdala and superior temporal sulcus were significantly higher in the HS side than the contralateral side for the localized group. The TBSS analyses showed significantly decreased FA in the WM tracts of the temporal and frontal lobes for the broad hypometabolic group, while no tracts showed significant differences for the localized group. CONCLUSION: The hypometabolic extension for HS was associated with the abnormalities of MD and FA in GM and WM, respectively, with more widespread microstructural alterations for broad hypometabolic HS.

    DOI： 10.1016/j.seizure.2021.04.007

    PubMed

  • Deep Learning–based Angiogram Generation Model for Cerebral Angiography without Misregistration Artifacts

    Daiju Ueda, Yutaka Katayama, Akira Yamamoto, Tsutomu Ichinose, Hironori Arima, Yusuke Watanabe, Shannon L. Walston, Hiroyuki Tatekawa, Hirotaka Takita, Takashi Honjo, Akitoshi Shimazaki, Daijiro Kabata, Takao Ichida, Takeo Goto, Yukio Miki

    Radiology   299 ( 3 )   203692 - 681   2021.03（ ISSN:0033-8419 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1148/radiol.2021203692

    PubMed

  • Preferential tumor localization in relation to <sup>18</sup>F-FDOPA uptake for lower‐grade gliomas

    Hiroyuki Tatekawa, Hiroyuki Uetani, Akifumi Hagiwara, Jingwen Yao, Talia C. Oughourlian, Issei Ueda, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Shadfar Bahri, Whitney B. Pope, Noriko Salamon, Benjamin M. Ellingson

    Journal of Neuro-Oncology   152 ( 3 )   573 - 582   2021.03（ ISSN:0167-594X ）

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    Publishing type：Research paper (scientific journal)  

    Purpose: Although tumor localization and 3,4-dihydroxy-6- F-fluoro-l-phenylalanine (FDOPA) uptake may have an association, preferential tumor localization in relation to FDOPA uptake is yet to be investigated in lower-grade gliomas (LGGs). This study aimed to identify differences in the frequency of tumor localization between FDOPA hypometabolic and hypermetabolic LGGs using a probabilistic radiographic atlas. Methods: Fifty-one patients with newly diagnosed LGG (WHO grade II, 29; III, 22; isocitrate dehydrogenase wild-type, 21; mutant 1p19q non-codeleted,16; mutant codeleted, 14) who underwent FDOPA positron emission tomography (PET) were retrospectively selected. Semiautomated tumor segmentation on FLAIR was performed. Patients with LGGs were separated into two groups (FDOPA hypometabolic and hypermetabolic LGGs) according to the normalized maximum standardized uptake value of FDOPA PET (a threshold of the uptake in the striatum) within the segmented regions. Spatial normalization procedures to build a 3D MRI-based atlas using each segmented region were validated by an analysis of differential involvement statistical mapping. Results: Superimposition of regions of interest showed a high number of hypometabolic LGGs localized in the frontal lobe, while a high number of hypermetabolic LGGs was localized in the insula, putamen, and temporal lobe. The statistical mapping revealed that hypometabolic LGGs occurred more frequently in the superior frontal gyrus (close to the supplementary motor area), while hypermetabolic LGGs occurred more frequently in the insula. Conclusion: Radiographic atlases revealed preferential frontal lobe localization for FDOPA hypometabolic LGGs, which may be associated with relatively early detection. 18

    DOI： 10.1007/s11060-021-03730-w

    PubMed

  • Differentiating IDH status in human gliomas using machine learning and multiparametric MR/PET

    Hiroyuki Tatekawa, Akifumi Hagiwara, Hiroyuki Uetani, Shadfar Bahri, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Noriko Salamon, Benjamin M. Ellingson

    Cancer Imaging   21 ( 1 )   27   2021.03（ ISSN:1740-5025 ）

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    Publishing type：Research paper (scientific journal)  

    Background: The purpose of this study was to develop a voxel-wise clustering method of multiparametric magnetic resonance imaging (MRI) and 3,4-dihydroxy-6-[ F]-fluoro-L-phenylalanine (FDOPA) positron emission tomography (PET) images using an unsupervised, two-level clustering approach followed by support vector machine in order to classify the isocitrate dehydrogenase (IDH) status of gliomas. Methods: Sixty-two treatment-naïve glioma patients who underwent FDOPA PET and MRI were retrospectively included. Contrast enhanced T1-weighted images, T2-weighted images, fluid-attenuated inversion recovery images, apparent diffusion coefficient maps, and relative cerebral blood volume maps, and FDOPA PET images were used for voxel-wise feature extraction. An unsupervised two-level clustering approach, including a self-organizing map followed by the K-means algorithm was used, and each class label was applied to the original images. The logarithmic ratio of labels in each class within tumor regions was applied to a support vector machine to differentiate IDH mutation status. The area under the curve (AUC) of receiver operating characteristic curves, accuracy, and F1-socore were calculated and used as metrics for performance. Results: The associations of multiparametric imaging values in each cluster were successfully visualized. Multiparametric images with 16-class clustering revealed the highest classification performance to differentiate IDH status with the AUC, accuracy, and F1-score of 0.81, 0.76, and 0.76, respectively. Conclusions: Machine learning using an unsupervised two-level clustering approach followed by a support vector machine classified the IDH mutation status of gliomas, and visualized voxel-wise features from multiparametric MRI and FDOPA PET images. Unsupervised clustered features may improve the understanding of prioritizing multiparametric imaging for classifying IDH status. 18

    DOI： 10.1186/s40644-021-00396-5

    PubMed

  • Voxelwise and Patientwise Correlation of <sup>18</sup>F-FDOPA PET, Relative Cerebral Blood Volume, and Apparent Diffusion Coefficient in Treatment-Naïve Diffuse Gliomas with Different Molecular Subtypes

    Hiroyuki Tatekawa, Akifumi Hagiwara, Jingwen Yao, Talia C. Oughourlian, Issei Ueda, Hiroyuki Uetani, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Noriko Salamon, Benjamin M. Ellingson

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine   62 ( 3 )   319 - 325   2021.03（ ISSN:0161-5505 ）

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    Publishing type：Research paper (scientific journal)  

    Our purpose was to identify correlations between 18F-fluorodihydroxyphenylalanine (18F-FDOPA) uptake and physiologic MRI, including relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC), in gliomas with different molecular subtypes and to evaluate their prognostic values. Methods: Sixty-eight treatment-naïve glioma patients who underwent 18F-FDOPA PET and physiologic MRI were retrospectively selected (36 with isocitrate dehydrogenase wild-type [IDHwt], 16 with mutant 1p/19q noncodeleted [IDHm-noncodel], and 16 with mutant codeleted [IDHm-codel]). Fluid-attenuated inversion recovery hyperintense areas were segmented and used as regions of interest. For voxelwise and patientwise analyses, Pearson correlation coefficients (rvoxelwise and rpatientwise) between the normalized SUV (nSUV), rCBV, and ADC were evaluated. Cox regression analysis was performed to investigate the associations between overall survival and rvoxelwise, maximum or median nSUV, median rCBV, or median ADC. Results: For IDHwt and IDHm-noncodel gliomas, nSUV demonstrated significant positive correlations with rCBV (rvoxelwise = 0.25 and 0.31, respectively; rpatientwise = 0.50 and 0.70, respectively) and negative correlations with ADC (rvoxelwise = -0.19 and -0.19, respectively; rpatientwise = -0.58 and -0.61, respectively) in both voxelwise and patientwise analyses. IDHm-codel gliomas demonstrated a significant positive correlation between nSUV and ADC only in voxelwise analysis (rvoxelwise = 0.18). In Cox regression analysis, rvoxelwise between nSUV and rCBV (hazard ratio, 28.82) or ADC (hazard ratio, 0.085) had significant associations with overall survival for only IDHwt gliomas. Conclusion: IDHm-codel gliomas showed distinctive patterns of correlations between amino acid PET and physiologic MRI. Stronger correlations between nSUV and rCBV or ADC may result in a worse prognosis for IDHwt gliomas.

    DOI： 10.2967/jnumed.120.247411

    PubMed

  • Maximum Uptake and Hypermetabolic Volume of 18F-FDOPA PET Estimate Molecular Status and Overall Survival in Low-Grade Gliomas: A PET and MRI Study.

    Hiroyuki Tatekawa, Jingwen Yao, Talia C Oughourlian, Akifumi Hagiwara, Chencai Wang, Catalina Raymond, Albert Lai, Timothy F Cloughesy, Phioanh L Nghiemphu, Linda M Liau, Noriko Salamon, Benjamin M Ellingson

    Clinical nuclear medicine   45 ( 12 )   e505 - e511   2020.12（ ISSN:0363-9762 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    PURPOSE: We evaluated F-FDOPA PET and MRI characteristics in association with the molecular status and overall survival (OS) in a large number of low-grade gliomas (LGGs). METHODS: Eighty-six patients who underwent F-FDOPA PET and MRI and were diagnosed with new or recurrent LGGs were retrospectively evaluated with respect to their isocitrate dehydrogenase (IDH) and 1p19q status (10 IDH wild type, 57 mutant, 19 unknown; 1p19q status in IDH mutant: 20 noncodeleted, 37 codeleted). After segmentation of the hyperintense area on fluid-attenuated inversion recovery image (FLAIRROI), the following were calculated: normalized SUVmax (nSUVmax) of F-FDOPA relative to the striatum, F-FDOPA hypermetabolic volume (tumor-to-striatum ratios >1), FLAIRROI volume, relative cerebral blood volume, and apparent diffusion coefficient within FLAIRROI. Receiver operating characteristic curve and Cox regression analyses were performed. RESULTS: PET and MRI metrics combined with age predicted the IDH mutation and 1p19q codeletion statuses with sensitivities of 73% and 76% and specificities of 100% and 94%, respectively. Significant correlations were found between OS and the IDH mutation status (hazard ratio [HR] = 4.939), nSUVmax (HR = 2.827), F-FDOPA hypermetabolic volume (HR = 1.048), and FLAIRROI volume (HR = 1.006). The nSUVmax (HR = 151.6) for newly diagnosed LGGs and the F-FDOPA hypermetabolic volume (HR = 1.038) for recurrent LGGs demonstrated significant association with OS. CONCLUSIONS: Combining F-FDOPA PET and MRI with age proved useful for predicting the molecular status in patients with LGGs, whereas the nSUVmax and F-FDOPA hypermetabolic volume may be useful for prognostication.

    DOI： 10.1097/RLU.0000000000003318

    PubMed

  • Focal cortical dysplasia imaging discrepancies between MRI and FDG-PET: Unique association with temporal lobe location

    Hajime Yokota, Hiroyuki Uetani, Hiroyuki Tatekawa, Akifumi Hagiwara, Emiko Morimoto, Michael Linetsky, Bryan Yoo, Benjamin M. Ellingson, Noriko Salamon

    Seizure   81   180 - 185   2020.10（ ISSN:1059-1311 ）

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    Publishing type：Research paper (scientific journal)  

    Purpose: Although magnetic resonance imaging (MRI) and F-2-fluorodeoxyglucose-positron emission tomography (FDG-PET) are used for pre-surgical assessment of focal cortical dysplasia (FCD), they often disagree. This study aimed to identify factors that contribute to discrepancies in FCD imaging between MRI and FDG-PET. Methods: Sixty-two patients (mean age, 18.9 years) with a FCD type I or II were retrospectively selected. These patients were visually categorized into two groups: 1) extent of PET abnormality larger than MRI abnormality and 2) vice versa or equivalent. Predictive factors of these two groups were analyzed by multivariate logistic regression. The extent of hypometabolic transient zone surrounding FCDs and their mean standardized uptake values were measured and compared by the Mann–Whitney U-test. Results: FCDs were detected on MRI and PET in 46 and 55 patients, respectively, whereas no abnormality was detected in 4 patients. The PET hypometabolic areas were larger than the MRI abnormal areas in 26 patients (88 % in the temporal lobe), whereas the PET hypometabolic areas were equivalent or smaller than the MRI abnormal areas in 32 patients (69 % in the frontal lobe). The temporal lobe location was an independent predictor for differentiating the two groups (OR = 35.2, 95 % CI = 6.81–168.0, P <.001). The temporal lobe lesions had significantly wider transient zones and lower standardized uptake values than those in the other lobes (P <.001, both). Conclusion: The discrepancies between MRI and FDG-PET findings of FCD were associated with temporal lobe location. 18

    DOI： 10.1016/j.seizure.2020.08.017

    PubMed

  • Multiparametric MR-PET measurements in hypermetabolic regions reflect differences in molecular status and tumor grade in treatment-naïve diffuse gliomas

    Hiroyuki Tatekawa, Akifumi Hagiwara, Hiroyuki Uetani, Jingwen Yao, Talia C. Oughourlian, Shadfar Bahri, Chencai Wang, Catalina Raymond, Albert Lai, Timothy F. Cloughesy, Phioanh L. Nghiemphu, Linda M. Liau, Whitney B. Pope, Noriko Salamon, Benjamin M. Ellingson

    Journal of Neuro-Oncology   149 ( 2 )   337 - 346   2020.09（ ISSN:0167-594X ）

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    Publishing type：Research paper (scientific journal)  

    Purpose: To assess whether hypermetabolically-defined regions of interest (ROIs) on 3,4-dihydroxy-6-[18F]-fluoro-l-phenylalanine (FDOPA) positron emission tomography (PET) could be used to evaluate physiological features and whether there are measurable differences between molecular subtypes and tumor grades. Methods: Sixty-eight treatment-naïve glioma patients who underwent FDOPA PET and magnetic resonance imaging (MRI) were retrospectively included. Fluid-attenuated inversion recovery hyperintense regions (FLAIR ) were segmented. FDOPA hypermetabolic regions (FDOPA , tumor-to-striatum ratios > 1) within FLAIR were extracted. Normalized maximum standardized uptake value (nSUV ), volume of each ROI, and median relative cerebral blood volume (rCBV) and apparent diffusion coefficient (ADC) within FLAIR or FDOPA were calculated. Imaging metrics were compared using Students t or Mann–Whitney U tests. Area under the curve (AUC) of receiver-operating characteristic curves were used to determine whether imaging metrics within FLAIR or FDOPA can discriminate different molecular statuses or grades. Results: Using either FLAIR or FDOPA , the nSUV and rCBV were significantly higher and the ADC was lower in isocitrate dehydrogenase (IDH) wild-type than mutant gliomas, and in higher-grade gliomas (HGGs) than lower-grade gliomas (LGGs). The FDOPA volume was significantly higher in 1p19q codeleted than non-codeleted gliomas, and in HGGs than LGGs. Although not significant, imaging metrics extracted by FDOPA discriminated molecular status and tumor grade more accurately than those extracted by FLAIR (AUC of IDH status, 0.87 vs. 0.82; 1p19q status, 0.78 vs. 0.73; grade, 0.87 vs. 0.76). Conclusion: FDOPA hypermetabolic ROI may extract useful imaging features of gliomas, which can illuminate biological differences between different molecular status or tumor grades. ROI ROI ROI max ROI ROI ROI ROI ROI ROI max ROI ROI ROI

    DOI： 10.1007/s11060-020-03613-6

    PubMed

  • Maximum Uptake and Hypermetabolic Volume of 18F-FDOPA PET Estimates Overall Survival in Low-Grade Gliomas

    Tatekawa Hiroyuki, Yao Jingwen, Wang Chencai, Oughourlian Talia, Raymond Catalina, Lai Albert, Cloughesy Timothy, Nghiemphu Phioanh, Liau Linda, Salamon Noriko, Ellingson Benjamin

    JOURNAL OF NUCLEAR MEDICINE   61   2020.05（ ISSN:0161-5505 ）

  • Rate of change in maximum <sup>18</sup>F-FDOPA PET uptake and non-enhancing tumor volume predict malignant transformation and overall survival in low-grade gliomas.

    Oughourlian TC, Yao J, Schlossman J, Raymond C, Ji M, Tatekawa H, Salamon N, Pope WB, Czernin J, Nghiemphu PL, Lai A, Cloughesy TF, Ellingson BM

    Journal of neuro-oncology   147 ( 1 )   135 - 145   2020.03（ ISSN:0167-594X ）

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  • Reduced left amygdala volume in patients with dissociative seizures (psychogenic nonepileptic seizures).

    Tatekawa H, Kerr WT, Savic I, Engel J Jr, Salamon N

    Seizure   75   43 - 48   2020.02（ ISSN:1059-1311 ）

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  • 両側眼窩尖部から両側対称性に周囲進展をきたした腺様嚢胞癌の1例

    寺山 英作, 下野 太郎, 立川 裕之, 三野 俊和, 桑江 優子, 三木 幸雄

    金原出版(株)　臨床放射線   64 ( 6 )   841 - 845   2019.05（ ISSN:0009-9252 ）

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    症例は70歳代女性で、来院半年前より左側眼瞼の挙上困難が出現したが様子をみていた。2ヵ月前より右側眼瞼の挙上困難も出現し、同時期に左頬のしびれ、両側の閉眼困難が出現した。両目がほとんど閉眼できなくなったため、当院神経内科受診となった。両側眼窩尖部、両側上眼窩裂、両側海綿静脈洞にT1強調像、T2強調像、拡散強調像で比較的内部均一で、中間信号強度を呈する辺縁不明瞭な病変を認めた。頭骨、前頭部硬膜より開頭下生検が施行された。生検組織のHE染色では両部位の検体より腫瘍細胞、異型腺管の浸潤と増殖を認めた。腫瘍細胞は篩状構造を形成し腺腔内に粘液を有しており、腺様嚢胞癌の最終診断となった。FDG PET-CT、上部・下部消化管内視鏡を含め、全身の精査が施行されたが明らかな病変は認められなかった。最終的に眼窩尖部〜蝶形骨洞原発の腺様嚢胞癌との臨床診断がなされ、放射線治療を施行した。照射後3年間、症状の増悪なく経過している。

  • Imaging Differences between Neuromyelitis Optica Spectrum Disorders and Multiple Sclerosis: A Multi-Institutional Study in Japan

    Tatekawa H., Sakamoto S., Hori M., Kaichi Y., Kunimatsu A., Akazawa K., Miyasaka T., Oba H., Okubo T., Hasuo K., Yamada K., Taoka T., Doishita S., Shimono T., Miki Y.

    AMERICAN JOURNAL OF NEURORADIOLOGY   39 ( 7 )   1239 - 1247   2018.07（ ISSN:0195-6108 ）

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  • Robinow症候群の2例

    米田 昌平, 下野 太郎, 藤田 賢司, 立川 裕之, 瀬戸 俊之, 三木 幸雄

    金原出版(株)　臨床放射線   63 ( 7 )   833 - 838   2018.07（ ISSN:0009-9252 ）

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    症例1は9ヵ月男児で、生後9ヵ月時に頭囲拡大と低身長を認めた。生後4ヵ月時に定頸、8ヵ月時に寝返り、2歳時に運動発達遅滞を認めた。頭部MRIでは、9ヵ月時のT2強調正中矢状断像で、前額部の突出、脳梁・脳幹の軽度萎縮を認めた。T2強調横断像では、両側メッケル腔の拡大、脳溝・側脳室前角の軽度拡大や軽度の脳梁萎縮を認めた。染色体検査では、常染色体劣性型Robinow症候群に特異的な遺伝子座9q22の異常を認めず、特徴的な顔貌や身体所見から常染色体優性型Robinow症候群と診断した。症例2は2ヵ月女児で、顔貌異常で受診し、多発奇形や精神・運動発達遅滞、低身長を認めた。6歳時から軽度の難聴を自覚し、10歳時より中耳炎を繰り返し罹患した。11歳時に両側滲出性中耳炎の診断で、両側鼓膜にチューブを挿入した。頭部MRI(3ヵ月時)では、T2強調正中矢状断像にて前額部の突出、脳梁・脳幹の軽度萎縮を認めた。T1強調横断像では、側脳室の軽度拡大と脳梁の軽度萎縮を認めた。特徴的な顔貌や身体所見などからRobinow症候群と診断した。

  • Imaging features of benign mass lesions in the nasal cavity and paranasal sinuses according to the 2017 WHO classification.

    Tatekawa H, Shimono T, Ohsawa M, Doishita S, Sakamoto S, Miki Y

    Japanese journal of radiology   36 ( 6 )   361 - 381   2018.06（ ISSN:1867-1071 ）

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  • 小脳萎縮を伴ったGM1ガングリオシドーシスtype 2の1例

    尾崎 正典, 下野 太郎, 濱崎 考史, 立川 裕之, 三木 幸雄

    金原出版(株)　臨床放射線   63 ( 4 )   455 - 459   2018.04（ ISSN:0009-9252 ）

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    1歳7ヵ月女児。主訴は発達遅滞であった。生後10ヵ月以降次第に発達遅滞を認め、生後16ヵ月で独歩不可能であった。脊椎側面単純X線では高度の後彎を認め、椎体は高さが減じ卵円形〜くちばし状のものまで認めた。頭部MRIのT2強調像では大脳皮質下白質から深部白質に淡い高信号を認め、両側の視床と淡蒼球に低信号を認め、小脳は萎縮していた。髄鞘形成遅延を呈する先天性代謝疾患が疑われ、遺伝子診断の結果、GLB1遺伝子のM1C変異とR49Gが確認され、GM1ガングリオシドーシスと診断した。その後MRIによる経過観察では大脳白質病変が徐々に目立ち、大脳や脳梁の萎縮を認めるようになり、視床と淡蒼球のT2強調像低信号化が明瞭化し、橋被蓋の萎縮も目立つようになった。

  • 出血発症した脊髄海綿状血管腫の2例

    島崎 覚理, 下野 太郎, 高見 俊宏, 立川 裕之, 桑江 優子, 三木 幸雄

    金原出版(株)　臨床放射線   63 ( 3 )   341 - 345   2018.03（ ISSN:0009-9252 ）

  • In vitro Study of Serial Changes to Carmustine Wafers (Gliadel) with MR Imaging and Computed Tomography.

    Doishita S, Shimono T, Yoneda T, Yamada E, Tsukamoto T, Takemori D, Kimura D, Tatekawa H, Sakamoto S, Miki Y

    日本磁気共鳴医学会　Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine   17 ( 1 )   58 - 66   2018.01（ ISSN:1347-3182 ）

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    <p>Purpose: Implantation of carmustine wafers (Gliadel) <i>in vivo</i> is accompanied by characteristic serial changes on MRI and CT, such as transient hyperintensity of the wafers on T<sub>1</sub>-weighted images (T<sub>1</sub>WIs) and considerable gas accumulation in surgical resection cavities. The purpose of this study was to evaluate intrinsic imaging changes to carmustine wafers <i>in vitro</i>.</p><p>Methods: Three phantoms simulating a surgical resection cavity were constructed. Each contained either a carmustine wafer fixed with oxidized regenerated cellulose and fibrin sealant, an unfixed carmustine wafer, or a fixed polyethylene control disk, immersed in phosphate-buffered saline. Image acquisition of the phantoms was performed on MRI and CT until 182 days after construction. The radiological appearances of the object in each phantom were assessed by visual evaluation and quantification of the region of interest. The volume of gas around the objects at 24 h after constructing the phantoms was also measured.</p><p>Results: The carmustine wafers showed low signal intensities on T<sub>1</sub>WIs and T<sub>2</sub>-weighted images (T<sub>2</sub>WIs), and high densities on CT images at 24 h. The signal intensities and CT densities gradually approximated those of saline over a period of months. However, the carmustine wafers never showed hyperintensity on T<sub>1</sub>WIs <i>in vitro</i>. The fixed carmustine wafer showed slower radiological changes, as compared to the unfixed wafer. The gas volume around the fixed carmustine wafer was greater than that around the fixed control disk.</p><p>Conclusion: Changes to the carmustine wafers probably reflected penetration of fluid inside and degradation of the hydrophobic matrix. Reported transient hyperintensity of wafers on T<sub>1</sub>WIs <i>in vivo</i> is regarded as the result of biological reactions, whereas the initial production of gas is considered as an intrinsic characteristic of wafers.</p>

    DOI： 10.2463/mrms.mp.2017-0035

    PubMed

    CiNii Article

  • Differentiation of Brain Metastases and Gliomas Based on Color Map of Phase Difference Enhanced Imaging.

    Doishita S, Sakamoto S, Yoneda T, Uda T, Tsukamoto T, Yamada E, Yoneyama M, Kimura D, Katayama Y, Tatekawa H, Shimono T, Ohata K, Miki Y

    Frontiers in neurology   9   788   2018（ ISSN:1664-2295 ）

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  • [MR imaging of multiple sclerosis].

    Tatekawa H, Miki Y

    Nihon rinsho. Japanese journal of clinical medicine   73 Suppl 7   158 - 66   2015.09（ ISSN:0047-1852 ）

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  • 【脳神経・頭頸部の診断と治療update】頭蓋底に発生したchondromyxoid fibromaの1例

    座古 竜世, 下野 太郎, 立川 裕之, 森迫 拓貴, 大澤 政彦, 三木 幸雄

    金原出版(株)　臨床放射線   60 ( 5 )   701 - 704   2015.05（ ISSN:0009-9252 ）

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    52歳女。鼻閉が徐々に増悪し、3年前に前医にて鼻腔内腫瘤を指摘され、生検結果から脊索腫の診断で経過観察されていたが、腫瘤の増大を認め当科受診となった。頭蓋底部単純CTでは斜台から蝶形骨を主座とする頭蓋底正中線上に溶骨性腫瘤性病変を認め、腫瘤内部辺縁に石灰化を認めた。頭蓋底部MRIで腫瘤は境界明瞭で、分葉状の形態を示し、T1強調像で低信号、T2強調像で不均一な高信号を呈し、拡散低下は示さず、Gd造影では多房性辺縁優位に造影効果を認めた。手術を行い、腫瘍は柔らかく脆い病変で、病理組織学的に軟骨性、線維性、粘液性の3成分を認め、chondromyxoid fibromaと診断した。術後6年経過の現在、再発は認めていない。

  • Multidetector CT findings of neurogenic appendicopathy Reviewed International coauthorship

    Tatekawa H, Tanikake M, Yoshida S, Sato F, Kurata Y, Hayakawa K, Matsuo K, Tamaki N, Hino Y, Urata Y

    European Journal of Radiology Extra   2011

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work  

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Books and Other Publications

  • 4. 多発性硬化症・視神経脊髄炎関連疾患・下垂体細胞腫/顆粒細胞腫/紡錘形細胞オンコサイトーマ

    立川裕之, 三木幸雄（ Role： Joint author）

    学研メディカル秀潤社・よくわかる脳MRI  2020 

  • 脱髄─多発性硬化症・視神経脊髄炎関連疾患・急性散在性脳脊髄炎

    立川裕之, 三木幸雄（ Role： Joint author）

    文光堂・Medical Practice  2018 

  • 下垂体細胞腫

    立川裕之, 三木幸雄（ Role： Joint author）

    Medical View・下垂体の画像診断  2017 

  • ライソゾーム病

    立川裕之, 塚本太朗, 土井下怜, 下野太郎（ Role： Joint author）

    Medical Science・脳のMRI  2015 

MISC

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Grant-in-Aid for Scientific Research

  • ディープラーニングを用いたMRI機能画像(DTIおよびNODDI)の生成

    Grant-in-Aid for Early-Career Scientists  2022.04

Other

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    2018.04 - 2018.08

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    2014.04 - 2018.03

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    2013.04 - 2014.03