S-allyl cysteine increases blood flow in NO-dependent and-independent manners(和訳中)

Takemura Shigekazu, Ihara Hideshi, Nakagawa Kanako, Minamiyama Yukiko

Glycative Stress Research   9 ( 3 )   146 - 157   2022.09（ ISSN:2188-3602 ）

2-Oxo-Imidazole-Containing Dipeptides Play a Key Role in the Antioxidant Capacity of Imidazole-Containing Dipeptides Reviewed

Kasamatsu, Shingo Komae, Somei Matsukura, Kana Kakihana, Yuki Uchida, Koji Ihara, Hideshi

Antioxidants 雑誌   10 ( 9 )   2021.09

Sulfide catabolism ameliorates hypoxic brain injury Reviewed

Marutani, E. Morita, M. Hirai, S. Kai, S. Grange, R. M. H. Miyazaki, Y. Nagashima, F. Traeger, L. Magliocca, A. Ida, T. Matsunaga, T. Flicker, D. R. Corman, B. Mori, N. Yamazaki, Y. Batten, A. Li, R. Tanaka, T. Ikeda, T. Nakagawa, A. Atochin, D. N. Ihara, H. Olenchock, B. A. Shen, X. Nishida, M. Hanaoka, K. Kevil, C. G. Xian, M. Bloch, D. B. Akaike, T. Hindle, A. G. Motohashi, H. Ichinose, F.

Nature communications 雑誌   12 ( 1 )   2021.05

High Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species Reviewed

Kasamatsu, S. Ida, T. Koga, T. Asada, K. Motohashi, H. Ihara, H. Akaike, T.

Antioxid Redox Signal 雑誌   34 ( 18 )   2021.05

Distribution and quantitative analysis of homoanserine and its 2-oxo derivative in mouse tissues Reviewed

Kakihana Y, Kasamatsu S, Uchida K, Ihara H

Free Radic Res 雑誌   2021.01

Generation of Rat Monoclonal Antibody to Detect Hydrogen Sulfide and Polysulfides in Biological Samples Reviewed

Kasamatsu, S. Kakihana, Y. Koga, T. Yoshioka, H. Ihara, H.

Antioxidants (Basel) 雑誌   9 ( 11 )   2020.11

High Precision Sulfur Metabolomics Innovated by a New Specific Probe for Trapping Reactive Sulfur Species Reviewed

Kasamatsu, S. Ida, T. Koga, T. Asada, K. Motohashi, H. Ihara, H. Akaike, T.

Antioxid Redox Signal 雑誌   2020.11

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides Reviewed

Sawa, Tomohiro Motohashi, Hozumi Ihara, Hideshi Akaike, Takaaki

Biomolecules 雑誌   10 ( 9 )   2020.08

8-Nitro-cGMP modulates exocytosis in adrenal chromaffin cells Reviewed

Tsutsuki, H. Kasamatsu, S. Kunieda, K. Ida, T. Sawa, T. Sasakawa, N. Akaike, T. Ihara, H.

Biochem Biophys Res Commun 雑誌   526 ( 1 )   2020.03

Enhanced Cellular Polysulfides Negatively Regulate TLR4 Signaling and Mitigate Lethal Endotoxin Shock Reviewed

Zhang, T., Ono, K., Tsutsuki, H., Ihara, H., Islam, W., Akaike, T., and Sawa, T.

Cell Chem Biol 雑誌   26   686 - 698   2019.05

8-Nitro-cGMP attenuates context-dependent fear memory in mice

Kishimoto Y.

Biochemical and Biophysical Research Communications   511 ( 1 )   141 - 147   2019.03（ ISSN:0006291X ）

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis Reviewed

Hamid, H. A., Tanaka, A., Ida, T., Nishimura, A., Matsunaga, T., Fujii, S., Morita, M., Sawa, T., Fukuto, J. M., Nagy, P., Tsutsumi, R., Motohashi, H., Ihara, H., and Akaike, T.

Redox Biology 雑誌   21   2019.02

8-Nitro-cGMP attenuates context-dependent fear memory in mice Reviewed

Kishimoto, Y. Kasamatsu, S. Yanai, S. Endo, S. Akaike, T. Ihara, H.

Biochem Biophys Res Commun 雑誌   511 ( 1 )   2019.02

Redox regulation of Ca2+/calmodulin-dependent protein kinase IV via oxidation of its active-site cysteine residue Reviewed

Takata, T., Kimura, J., Ihara, H., Hatano, N., Tsuchiya, Y., and Watanabe, Y.

Free Radic. Biol. Med. 雑誌   130   99 - 106   2019.01

2-Oxo-histidine-containing dipeptides are functional oxidation products Reviewed

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K., and Uchida, K.

J. Biol. Chem. 雑誌   294   1279 - 1289   2019.01

SNAP-25 S-Guanylation and SNARE Complex Formation Reviewed

Kishimoto, Y., Akaike, T., and Ihara, H.

Methods Mol. Biol. 雑誌   1860   163 - 173   2019.01

Involvement of nitric oxide/reactive oxygen species signaling via 8-nitro-cGMP formation in 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells and rat cerebellar granule neurons Reviewed

Masuda, K., Tsutsuki, H., Kasamatsu, S., Ida, T., Takata, T., Sugiura, K., Nishida, M., Watanabe, Y., Sawa, T., Akaike, T., and Ihara, H.

Biochem. Biophys. Res. Commun. 雑誌   495   2165 - 2170   2018.01

8-Nitro-cGMP Attenuates the Interaction between SNARE Complex and Complexin through S-Guanylation of SNAP-25 Reviewed

Kishimoto, Y., Kunieda, K., Kitamura, A., Kakihana, Y., Akaike, T., and Ihara, H.

ACS Chem. Neurosci. 雑誌   9   217 - 223   2017.11

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics Reviewed

Akaike, T., Ida, T., Wei, F. Y., Nishida, M., Kumagai, Y., Alam, M. M., Ihara, H., Sawa, T., Matsunaga, T., Kasamatsu, S., Nishimura, A., Morita, M., Tomizawa, K., Nishimura, A., Watanabe, S., Inaba, K., Shima, H., Tanuma, N., Jung, M., Fujii, S., Watanabe, Y., Ohmuraya, M., Nagy, P., Feelisch, M., Fukuto, J. M., and Motohashi, H

Nat Commun 雑誌   8   2017.10

8-Nitro-cGMP promotes bone growth through expansion of growth plate cartilage Reviewed

Hoshino, M., Kaneko, K., Miyamoto, Y., Yoshimura, K., Suzuki, D., Akaike, T., Sawa, T., Ida, T., Fujii, S., Ihara, H., Tanaka, J., Tsukuura, R., Chikazu, D., Mishima, K., Baba, K., and Kamijo, R.

Free Radic. Biol. Med. 雑誌   110   63 - 71   2017.09

Ferulic acid and its water-soluble derivatives inhibit nitric oxide production and inducible nitric oxide synthase expression in rat primary astrocytes Reviewed

Kikugawa, M., Ida, T., Ihara, H., and Sakamoto, T.

Biosci. Biotechnol. Biochem. 雑誌   81   1607 - 1611   2017.08

Exposure to Electrophiles Impairs Reactive Persulfide-dependent Redox Signaling in Neuronal Cells Reviewed

Ihara, H., Kasamatsu, S., Kitamura, A., Nishimura, A., Tsutsuki, H., Ida, T., Ishizaki, K., Toyama, T., Yoshida, E., Abdul Hamid, H., Jung, M., Matsunaga, T., Fujii, S., Sawa, T., Nishida, M., Kumagai, Y., and Akaike, T.

Chem. Res. Toxicol. 雑誌   30   1673 - 1684   2017.08

Reactive sulfur species inactivate Ca2+/calmodulin-dependent protein kinase IV via S-polysulfidation of its active-site cysteine residue Reviewed

Takata, T., Ihara, H., Hatano, N., Tsuchiya, Y., Akaike, T., and Watanabe, Y.

Biochem. J. 雑誌   474   2547 - 2562   2017.07

Synthesis of L-cysteine derivatives containing stable sulfur isotopes and application of this synthesis to reactive sulfur metabolome Reviewed

Ono, K., Jung, M., Zhang, T., Tsutsuki, H., Sezaki, H., Ihara, H., Wei, F. Y., Tomizawa, K., Akaike, T., and Sawa, T.

Free Radic. Biol. Med. 雑誌   106   69 - 79   2017.05

Quantitative determination of polysulfide in albumins, plasma proteins and biological fluid samples using a novel combined assays approach Reviewed

Ikeda, M., Ishima, Y., Shibata, A., Chuang, V. T. G., Sawa, T., Ihara, H., Watanabe, H., Xian, M., Ouchi, Y., Shimizu, T., Ando, H., Ukawa, M., Ishida, T., Akaike, T., Otagiri, M., and Maruyama, T.

Anal. Chim. Acta 雑誌   969   18 - 25   2017.05

Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation Reviewed

Ihara, H., Kitamura, A., Kasamatsu, S., Ida, T., Kakihana, Y., Tsutsuki, H., Sawa, T., Watanabe, Y., and Akaike, T.

Biochem. J. 雑誌   474   1149 - 1162   2017.03

Endogenous occurrence of protein S-guanylation in Escherichia coli: Target identification and genetic regulation Reviewed

Tsutsuki, H., Jung, M., Zhang, T., Ono, K., Ida, T., Kunieda, K., Ihara, H., Akaike, T., and Sawa, T.

Biochem. Biophys. Res. Commun. 雑誌   478   7 - 11   2016.09

Optimization of a Neurotoxin to Investigate the Contribution of Excitatory Interneurons to Speed Modulation In Vivo Reviewed

Sternberg, J. R., Severi, K. E., Fidelin, K., Gomez, J., Ihara, H., Alcheikh, Y., Hubbard, J. M., Kawakami, K., Suster, M., and Wyart, C.

Curr. Biol. 雑誌   26   2319 - 2328   2016.09

Naringin lauroyl ester inhibits lipopolysaccharide-induced activation of nuclear factor κB signaling in macrophages Reviewed

Hattori, H., Tsutsuki, H., Nakazawa, M., Ueda, M., Ihara, H., and Sakamoto, T.

Biosci. Biotechnol. Biochem. 雑誌   80   1403 - 1409   2016.07

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides Reviewed

Fujii, S., Sawa, T., Nishida, M., Ihara, H., Ida, T., Motohashi, H., and Akaike, T.

Arch. Biochem. Biophys. 雑誌   595   140 - 146   2016.04

Redox signaling regulated by electrophiles and reactive sulfur species Reviewed

Nishida, M., Kumagai, Y., Ihara, H., Fujii, S., Motohashi, H., and Akaike, T.

J. Clin. Biochem. Nutr. 雑誌   58   91 - 98   2016.03

Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation Reviewed

Kikugawa, M., Tsutsuki, H., Ida, T., Nakajima, H., Ihara, H., and Sakamoto, T.

Biosci. Biotechnol. Biochem. 雑誌   80   547 - 553   2016.03

Formation of Sulfur Adducts of N-Acetyl-p-benzoquinoneimine, an Electrophilic Metabolite of Acetaminophen in Vivo: Participation of Reactive Persulfides Reviewed

Abiko, Y., Ishii, I., Kamata, S., Tsuchiya, Y., Watanabe, Y., Ihara, H., Akaike, T., and Kumagai, Y.

Chem. Res. Toxicol. 雑誌   28   1796 - 1802   2015.08

8-Nitro-cGMP Enhances SNARE Complex Formation through S-Guanylation of Cys90 in SNAP25 Reviewed

Kunieda, K., Tsutsuki, H., Ida, T., Kishimoto, Y., Kasamatsu, S., Sawa, T., Goshima, N., Itakura, M., Takahashi, M., Akaike, T., and Ihara, H.

ACS Chem. Neurosci. 雑誌   6   1715 - 1725   2015.07

8-Mercapto-Cyclic GMP Mediates Hydrogen Sulfide-Induced Stomatal Closure in Arabidopsis Reviewed

Honda, K., Yamada, N., Yoshida, R., Ihara, H., Sawa, T., Akaike, T., and Iwai, S.

Plant Cell Physiol. 雑誌   56   1481 - 1489   2015.05

Nuclear-translocated glyceraldehyde-3-phosphate dehydrogenase promotes Poly(ADP-ribose) polymerase-1 activation during oxidative/nitrosative stress in stroke Reviewed

Nakajima, H., Kubo, T., Ihara, H., Hikida, T., Danjo, T., Nakatsuji, M., Shahani, N., Itakura, M., Ono, Y., Azuma, Y. T., Inui, T., Kamiya, A., Sawa, A., and Takeuchi, T.

J. Biol. Chem. 雑誌   290   14493 - 14503   2015.04

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling Reviewed

Ida, T., Sawa, T., Ihara, H., Tsuchiya, Y., Watanabe, Y., Kumagai, Y., Suematsu, M., Motohashi, H., Fujii, S., Matsunaga, T., Yamamoto, M., Ono, K., Devarie-Baez, N. O., Xian, M., Fukuto, J. M., and Akaike, T.

Proc. Natl. Acad. Sci. U. S. A. 雑誌   111   7606 - 7611   2014.05

Redox signal regulation via nNOS phosphorylation at Ser847in PC12 cells and rat cerebellar granule neurons Reviewed

Kasamatsu, S., Watanabe, Y., Sawa, T., Akaike, T., and Ihara, H. (2014)

Biochem. J. 雑誌   459   107 - 116   2014.04

Theophylline Potentiates Lipopolysaccharide-iduced NO Production in Cultured Astrocytes Reviewed

Ogawa, M. Takano, K. Kawabe, K. Moriyama, M. Ihara, H. Nakamura, Y.　

Neurochem. Res. 雑誌   39 ( 1 )   107 - 116   2014.01

Nitric oxide enhances increase in cytosolic Ca2+ and promotes nicotine- triggered MAPK pathway in PC12 cells

Nitric Oxide   34 ( 1 )   2013.11

Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide.

Nitric Oxide   34 ( 1 )   2013.11

Substrate specificity and gene expression of two Penicillium chrysogenum α-L: -arabinofuranosidases (AFQ1 and AFS1) belonging to glycoside hydrolase families 51 and 54 Reviewed

Sakamoto T, Inui M, Yasui K, Hosokawa S, Ihara H

Appl Microbiol Biotechnol. 雑誌   97 ( 3 )   1121 - 30   2013.02

Studies on fish scale collagen of pacific saury (Cololabis saira) Reviewed

Mori H, Tone Y, Shimizu K, Zikihara K, Tokutomi S, Ida T, Ihara H, Hara M

Materials Science and Engineering C 雑誌   33 ( 1 )   174 - 81   2013.01

Subtilase cytotoxin enhances E. coli survival in macrophages by suppression of nitric oxide production through the inhibition of NF-κB activation Reviewed

Tsutsuki H, Yahiro K, Suzuki K, Suto A, Ogura K, Nagasawa S, Ihara H, Shimizu T, Nakajima H, Moss J, Noda M

Infect. Immun. 雑誌   80 ( 11 )   3939 - 51   2012.11

Inhibition of Nitric Oxide Production and Inducible Nitric Oxide Synthase Expression by a Polymethoxyflavone from Young Fruits of Citrus unshiu in Rat Primary Astrocytes Reviewed

IHARA H, YAMAMOTO H, IDA T,TSUTSUKI H, SAKAMOTO T,FUJITA T,OKADA T, KOZAKI S

Biosci Biotechnol Biochem. 雑誌   76 ( 10 )   1843 - 8   2012.10

Hydrogen sulfide anion regulates redox signaling via electrophile sulfhydration. Reviewed

Nishida M, Sawa T, Kitajima N, Ono K, Inoue H, Ihara H, Motohashi H, Yamamoto M, Suematsu M, Kurose H, van der Vliet A, Freeman BA, Shibata T, Uchida K, Kumagai Y, Akaike T.

Nature Chemical Biology 雑誌   8   714 - 24   2012.08

Induction of Apoptosis in MCF-7 Cells by β-1,3-Xylooligosaccharides Prepared from Caulerpa lentillifera. Reviewed

Maeda R, Ida T, Ihara H, Sakamoto T.

Biosci Biotechnol Biochem. 雑誌   76 ( 5 )   1032 - 4   2012.05

Specificity of botulinum protease for human VAMP family proteins. Reviewed

Yamamoto H, Ida T, Tsutsuki H, Mori M, Matsumoto T, Kohda T, Mukamoto M, Goshima N, Kozaki S, Ihara H

Microbiol Immunol. 雑誌   56 ( 4 )   245 - 53   2012.04

Immunostimulatory Activity of Polysaccharides Isolated from Caulerpa lentillifera on Macrophage Cells. Reviewed

Maeda R, Ida T, Ihara H, Sakamoto T.

Biosci Biotechnol Biochem. 雑誌   76 ( 3 )   501 - 5   2012.03

Regulation by mitochondrial superoxide and NADPH oxidase of cellular formation of nitrated cyclic GMP: potential implications for ROS signaling. Reviewed

Ahmed KA, Sawa T, Ihara H, Kasamatsu S, Yoshitake J, Rahaman MM, Okamoto T, Fujii S, Akaike T.

Biochem. J. 雑誌   441 ( 2 )   719 - 30   2012.01

Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells Reviewed

Miyamoto Y, Sakai R, Maeda C, Takata T, Ihara H, Tsuchiya Y, Watanabe Y.

Nitric Oxide 雑誌   25 ( 3 )   344 - 9   2011.10

Methodological proof of immunochemistry for specific identification of 8-nitroguanosine 3´,5´-cyclic monophosphate formed in glia cells Reviewed

Ihara H, Ahtesham AK, Ida T, Kasamatsu S, Kunieda K, Okamoto T, Sawa T, Akaike T.

Nitric Oxide 雑誌   25 ( 2 )   169 - 75   2011.08

Identification of a GH62 α-L: -arabinofuranosidase specific for arabinoxylan produced by Penicillium chrysogenum Reviewed

Sakamoto T, Ogura A, Inui M, Tokuda S, Hosokawa S, Ihara H, Kasai N

Appl. Microbiol. Biotechnol. 雑誌   90 ( 1 )   137 - 46   2011.04

Antioxidant effect of a nitrated cyclic nucleotide functioning as an endogenous electrophile Reviewed

Sawa T, Ihara H, Akaike T

Curr. Top. Med. Chem. 雑誌   11 ( 14 )   1854 - 1860   2011.04

Characterization of Trichoderma polysporum from Spitsbergen, Svalbard archipelago, Norway, with species identity, pathogenicity to moss, and polygalacturonase activity Reviewed

Yamazaki Y, Tojo M, Hoshino T, Kida K, Sakamoto T, Ihara H, Yumoto I, Tronsmo AM, Kanda H

Fungal Ecol. 雑誌   4 ( 1 )   15 - 21   2011.02

PKC-Dependent Inhibition of Ca2+-Dependent Exocytosis from Astrocytes Reviewed

Yasuda K, Itakura M, Aoyagi K, Sugaya T, Nagata E, Ihara H, Takahashi M

Glia 雑誌   59 ( 1 )   143 - 51   2011.01

Nucleotides function as endogenous chemical sensors for oxidative stress signaling Reviewed

Ihara H, Sawa T, Nakabeppu Y, Akaike T

J. Clin. Biochem. Nutr. 雑誌   48 ( 1 )   2011.01

Cell signaling mediated by nitrated cyclic guanine nucleotide Reviewed

Akaike T, Fujii S, Sawa T, Ihara H.

Nitric Oxide 雑誌   23 ( 3 )   166 - 174   2010.11

The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response. Reviewed

第一著者Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T.

J. Biol. Chem. 雑誌   285 ( 31 )   23970 - 84   2010.07

Effects of low protein intake on the development of the remaining kidney in subtotally nephrectomized immature rats: expression of inducible and endothelial NO synthase. Reviewed

Mino M, Ihara H, Kozaki S, Kondo T, Takeshita A, Kusakabe KT, Okada T.

Med. Mol. Morphol. 雑誌   43 ( 2 )   116 - 122   2010.06

Identification of two GH27 bifunctional proteins with beta-L-arabinopyranosidase/alpha-D-galactopyranosidase activities from Fusarium oxysporum. Reviewed

Sakamoto T, Tsujitani Y, Fukamachi K, Taniguchi Y, Ihara H.

Appl Environ Microbiol. 雑誌   86 ( 4 )   1115 - 24   2010.04

Glyceraldehyde-3-phosphate dehydrogenase aggregate formation participates in oxidative stress-induced cell death. Reviewed

Nakajima H, Amano W, Kubo T, Fukuhara A, Ihara H, Azuma YT, Tajima H, Inui T, Sawa A, Takeuchi T

J. Biol. Chem. 雑誌   284 ( 49 )   34331 - 41   2009.12

Characteristics of enterotoxin H-producing Staphylococcus aureus isolated from clinical cases and properties of the enterotoxin productivity Reviewed

Sakai F, Ihara H, Aoyama K, Igarashi H, Yanahira S, Ohkubo T, Asao T, Kozaki S

J Food Prot 雑誌   71 ( 9 )   1855 - 1860   2008.09

Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D. Reviewed

Tsukamoto K, Kozai Y, Ihara H, Kohda T, Mukamoto M, Tsuji T, Kozaki S.

Microb Pathog 雑誌   44 ( 6 )   484 - 493   2008.06

Nitric oxide-mediated modulation of calcium/calmodulin-dependent protein kinase II. Reviewed

Song T, Hatano N, Kambe T, Miyamoto Y, Ihara H, Yamamoto H, Sugimoto K, Kume K, Yamaguchi F, Tokuda M, Watanabe Y.

Biochemical Journal 雑誌   412 ( 2 )   223 - 231   2008.06

Study of the irreversible binding of Bacillus　thuringiensis CryIAa to brush border membrane　vesicles from Bombyx mori midgut Reviewed

Ihara H, Himeno M

Journal of Invertebrate Pathology 雑誌   98 ( 2 )   177 - 183   2008.06

Cellular responses in the spinal cord during development of hypomyelination in the mv rat. Reviewed

Izawa T, Takenaka S, Ihara H, Kotani T, Yamate J, Franklin RJ, Kuwamura M.

Brain Research 雑誌   21 ( 1195C )   120 - 129   2008.02

Cytokine-induced enhancement of calcium-dependent glutamate release from astrocytes mediated by nitric oxide Reviewed

責任著者Ida T, Hara M, Nakamura Y, Kozaki S, Tsunoda S, Ihara H.

Neuroscience letters 雑誌   432 ( 3 )   232 - 236   2008.02

Aspartyl-tRNA synthetases from two halophilic archae　Halobacterium salinarum and Haloferax volcanii Reviewed

Ihara H, Shinoda H, Yamaji R, Inui H, Miyatake K, Wadano A, Nakano　Y, Ishigami M

Applied Biological Science 雑誌   9   1 - 14   2008.01

Protein S-guanylation by the biological signal　8-nitroguanosine 3',5'-cyclic monophosphate Reviewed

Sawa T, Zaki MH, Okamoto T, Akuta T, Tokutomi T, Kim-Mitsuyama　S, Ihara H, Kobayashi A, Yamamoto M, Fujii S,　Arimoto H, Akaike T

Nature Chemical Biology 雑誌   3 ( 11 )   727 - 735   2007.11

Alternative polyadenylation sites of human endothelial nitric oxide synthase mRNA Reviewed

Ihara H, Tsutsuki H, Ida T, Kozaki S, Tsuyama S, Moss J

Biochemical and Biophysical Research Communications 雑誌   363   146 - 152   2007.08

Characterization of {beta}-1,6-galactanase of Fusarium oxysporum, an enzyme that hydrolyzes larch wood arabinogalactan. Reviewed

Sakamoto T, Taniguchi Y, Suzuki S, Ihara H, Kawasaki H.

Appl Environ Microbiol. 雑誌   73 ( 9 )   3109 - 12   2007.05

Nitric oxide inhibits depolarization-evoked glutamate release from rat cerebellar granule cells Reviewed

責任著者Tsutsuki H, Kohda T, Hara M, Kozaki S, Ihara H

Nitric Oxide 雑誌   16 ( 2 )   217 - 227   2007.03

Differential contribution of the residues in C-terminal half of heavy chain of botulinum neurotoxin type B to its binding to ganglioside and synaptotagmin 2/ganglioside Reviewed

Kohda T, Ihara H, Seto Y, Nakaya T, Tsustsuki H, Mukamoto M, Kozaki

Microbial Pathogenesis 雑誌   42 ( 2-3 )   72 - 79   2007.02

P90 RSK-1 associates with and inhibits neuronal nitric-oxide synthase Reviewed

Song T, Sugimoto K, Ihara H, Mizutani A, Hatano N, Kume K, Kambe　T,　Yamaguchi F,　Tokuda M,　Watanabe Y

Biochemical Journal 雑誌   401 ( 2 )   391 - 398   2007.01

Expression of neuronal nitric oxide synthase variant, nNOS-m, in rat brain Reviewed

Ihara H, Kuwamura M, Atsuta M, Nihonmatsu I, Okada T, Mukamoto M, Kozaki S

Nitric Oxide 雑誌   15 ( 1 )   13 - 19   2006.08

Expression of　foreign type I ribulose-1,5-bisphosphate carboxylase/oxygenase (EC 4.1.1.39) stimulates photosynthesis in cyanobacterium Synechococcus PCC7942 cells Reviewed

Iwaki T, Haranoh K, Inoue N, Kojima K, Satoh R, Nishino T, Wada S,　Ihara H, Tsuyama S, Kobayashi H, Wadano A,

Photosynthesis Research 雑誌   88 ( 3 )   287 - 297   2006.06

Potentiation by high potassium of lipopolysaccharide-induced nitric oxide production from cultured astrocytes Reviewed

Nakamura Y, Kitagawa T, Ihara H, Kozaki S, Moriyama M, Kannan Y

Neurochemistry International 雑誌   48 ( 1 )   43 - 49   2006.01

Binding of Clostridium botulinum type C and D neurotoxins to ganglioside and phospholipid. Novel insights into the receptor for clostridial neurotoxins Reviewed

Tsukamoto K, Kohda T, Mukamoto M, Takeuchi K, Ihara H, Saito M, Kozaki S

J. Biol. Chem. 雑誌   280 ( 42 )   35164 - 35171   2005.10

Molecular identification of a cold-adapated endo-arabinanase of Penicillium chrysogenum Reviewed

第一著者Sakamoto T, Ihara H, Shibano A, Nagahiro H, Kawasaki H

J. Appl. Glycosci. 雑誌   52 ( 4 )   369 - 372   2005.10

A novel neurotoxoid vaccine prevents mucosal botulism Reviewed

Kobayashi R, Kohda T, Kataoka K, Ihara H, Kozaki S, Pascual DW, Staats HF, Kiyono H, McGhee JR, Fujihashi K.

Journal of Immunlogy 雑誌   174 ( 4 )   2190 - 2195   2005.02

Differential effects of interferon-gamma on production of trypanosome-derived lymphocyte-triggering factor by Trypanosoma brucei gambiense and Trypanosoma brucei brucei Reviewed

Nishimura K, Hamashita K, Okamoto Y, Kawahara F, Ihara H, Kozaki S, Ohnishi Y, Yamasaki S

JOURNAL OF PARASITOLOGY 雑誌   90 ( 4 )   740 - 745   2004.08

Molecular characterization of a Penicillium chrysogenum exo-1,5-alpha-L-arabinanase that is structurally distinct from other arabinan-degrading enzymes Reviewed

第一著者Sakamoto T, Ihara H, Shibano A, Kasai N, Inui H, Kawasaki H

FEBS LETTERS 雑誌   560 ( 1-3 )   199 - 204   2004.02

A cold-adapted endo-arabinanase from Penicillium chrysogenum Reviewed

Sakamoto T, Ihara H, Kozaki S, Kawasaki H

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 雑誌   1624 ( 1-3 )   740 - 745   2003.12

Sequence of the gene for Clostridium botulinum type B neurotoxin associated with infant botulism, expression of the C-terminal half of heavy chain and its binding activity Reviewed

Ihara H, Kohda T, Morimoto F, Tsukamoto K, Karasawa T, Nakamura S, Mukamoto M, Kozaki S

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 雑誌   1625 ( 1 )   19 - 26   2003.01

Characterization of Clostridium butyricum neurotoxin associated with food-borne botulism Reviewed

Tsukamoto K, Mukamoto M, Kohda T, Ihara H, Wang XM, Maegawa T, Nakamura S, Karasawa T, Kozaki S

MICROBIAL PATHOGENESIS 雑誌   33 ( 4 )   177 - 184   2002.10

Characterization of a novel monoclonal antibody that senses nitric oxide-dependent activation of soluble guanylate cyclase Reviewed

Shingo Tsuyama, Eri Yamazaki, Takeshi Tomita, Hideshi Ihara, Shigeo Takenaka, Keiko Kato, Shunji Kozaki

FEBS Lett 雑誌   455 ( 3 )   291 - 294   1999.07

Endothelial nitric oxide synthase as a potential susceptibility gene in the pathogenesis of emphysema in alpha-antitrypsin deficiency Reviewed

Alexy Novoradovsky, Mark L. Brantly, Myron A. Waclawiw, Prerna P. Chaudhary, Hideshi Ihara, Lin Qi, N. Tony Eissa, Pauline M. Barnes, Kateri M. Gabriele, Mary E. Ehrmantraut, Paola Rogliani, Joel Moss

Am. J. Respir. Cell Mol. Biol. 雑誌   20 ( 3 )   441 - 447   1999.05

Purification and partial amino acid sequences of the binding protein from Bombyx mori for CryIAa ?-endotoxin of Bacillus thuringiensis Reviewed

H. Ihara, T. Uemura, M. Masuhara, S. Ikawa, K. Sugimoto, A. Wadano, M. Himeno

Comp. Biochem. Physiol. 雑誌   120B ( 1 )   9197 - 9204   1998.05

Molecular evolution of aspartyl tRNA synthetases and origin of universal genetic code and urkingdoms of living things Reviewed

M. Ishigami, H. Ihara, H. Shinoda

Viva Origino 雑誌   25   73 - 86   1997.11

Molecular evolution of aminoacyl tRNA synthetases and origin of universal genetic code Reviewed

M. Ishigami, H. Ihara, H. Shinoda

Proceedings of the 5th International Conference on Bioastronomy, 雑誌   483 - 489   1997.07

Three extracellular chitinases in suspension-cultured rice cells elicited by N-acetylchitooligosaccharides Reviewed

H. Inui, Y. Yamaguchi, Yo. Ishigami, S. Kawaguchi, T. Yamada, H. Ihara, S. Hirano

Biosci. Biotech. Biochem. 雑誌   60 ( 12 )   1956 - 1961   1996.12

Mode of action of ?-endotoxin from Bacillus thuringiensis var. aizawai Reviewed

M. Himeno, H. Ihara

MOLECULAR ACTION OF INSECTICIDES ON ION CHANNELS ACS SYMPOSIUM SERIES 雑誌   591   330 - 343   1995.01

Specific toxicity of ?-endotoxins from Bacillus thuringiensis to Bombyx mori Reviewed

H. Ihara, E. Kuroda, A. Wadano, M. Himeno

Biosci. Biotech. Biochem. 雑誌   57 ( 2 )   200 - 204   1993.02

Fluorometric assay of potential change of Bombyx mori midgut brush border membrane induced by ?-endotoxin from Bacillus thuringiensis Reviewed

T. Uemura, H. Ihara, A. Wadano, M. Himeno

Biosci. Biotech. Biochem. 雑誌   56 ( 12 )   1976 - 1979   1992.12

Purification and some properties of isocitrate dehydrogenase of a blowfly Aldrichina grahami Reviewed

A. Wadano, K. Miura, H. Ihara, N. Kondo, M. Taniguch

Comp. Biochem. Physiol. 雑誌   94B ( 1 )   189 - 194   1989.01

RSSの生体内検出とイメージング

居原秀、大内雅也（ Role： Joint author）

細胞工学  2015.04 

レドックスメタボロミクス

　（ Role： Joint author）

　  2013.11 

細胞の酸化ストレスを量る

　（ Role： Joint author）

　  2013.04 

活性酸素シグナルの調節機構-ROS毒性説から脱却した新たな概念

　（ Role： Joint author）

　  2013.02 

硫化水素と硫化水素シグナル関連物質の検出・定量

居原秀、井田智章（ Role： Joint author）

　  2012.10 

喫煙と酸化ストレス Oxidative stress induced bycigarette smoking.

岡本竜哉, 居原秀, 赤池孝章（ Role： Joint author）

　  2011.07 

細菌性神経毒素とガングリオシド

居原秀、小崎俊司（ Role： Joint author）

　  2009.06 

クロストリジウム神経毒素の受容体認識

小崎俊司、居原秀（ Role： Joint author）

　  2009.06 

生物化学実験法47「PCR実験マニュアル」原理から応用まで

居原秀　他16名（ Role： Joint author）

学会出版センター  2002.06 

活性イオウ分子種によるレドックスシグナル伝達の制御(Recent Developments in Research of Reactive Sulfur Species: Regulation of redox signaling by reactive sulfur species)

Kasamatsu Shingo, Ihara Hideshi

Journal of Clinical Biochemistry and Nutrition   68 ( 2 )   111 - 115   2021.03（ ISSN:0912-0009 ）

Regulation of redox signaling by reactive sulfur species Reviewed

Kasamatsu S, Ihara H

J Clin Biochem Nutr   68   111 - 115   2020.11

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides Reviewed

Tomohiro Sawa,Hozumi Motohashi , Hideshi Ihara and Takaaki Akaike

Biomolecules   10 ( 9 )   2020.08

【食と健康を結ぶメディカルサイエンス　生体防御系を亢進し、健康の維持に働く分子機構】(第2章)食による生体防御系の活性化　酸化イミダゾールジペプチドによる生体機能調節

垣花 優希, 笠松 真吾, 居原 秀

実験医学   38 ( 10 )   1637 - 1643   2020.06（ ISSN:0288-5514 ）

活性硫黄研究の新展開

居原 秀, 本橋 ほづみ, 赤池 孝章

生化学   91 ( 3 )   388 - 398   2019.06（ ISSN:0037-1017 ）

新規アルキル化試薬N-iodoacetyl tyrosine methyl esterを用いた超硫黄メタボローム・プロテオーム解析系の構築

笠松 真吾, 井田 智章, 古賀 大聖, 浅田 康勝, 本橋 ほづみ, 赤池 孝章, 居原 秀

日本生化学会大会プログラム・講演要旨集  2021.11  (公社)日本生化学会

アルツハイマー病モデルマウス脳内における活性硫黄分子オミクス解析

金野 文香, 笠松 真吾, 赤池 孝章, 居原 秀

日本生化学会大会プログラム・講演要旨集  2021.11  (公社)日本生化学会

2-オキソカルノシンの抗酸化メカニズムに関する研究

小前 奏明, 笠松 真吾, 内田 浩二, 居原 秀

日本生化学会大会プログラム・講演要旨集  2021.11  (公社)日本生化学会

2-オキソ-カルノシンはカルノシンの抗酸化活性の本体か？ Domestic conference

居原秀、笠松真吾、垣花優希、 小前奏明、松倉加奈、内田浩二

第75回日本栄養・食糧学会大会  2021.07 

2- オキソイミダゾールジペプチドの抗酸化 活性測定 Domestic conference

小前奏明、笠松真吾、松倉加奈、 内田浩二、居原秀

第75回日本栄養・食糧学会大会  2021.07 

2- オキソカルノシンの活性測定 Domestic conference

松倉加奈、笠松真吾、小前奏明、 内田浩二、居原秀

第75回日本栄養・食糧学会大会  2021.07 

2-オキソカルノシンの活性測定

松倉 加奈, 笠松 真吾, 小前 奏明, 内田 浩二, 居原 秀

日本栄養・食糧学会大会講演要旨集  2021.07  (公社)日本栄養・食糧学会

2-オキソイミダゾールジペプチドの抗酸化活性測定

小前 奏明, 笠松 真吾, 松倉 加奈, 内田 浩二, 居原 秀

日本栄養・食糧学会大会講演要旨集  2021.07  (公社)日本栄養・食糧学会

2-オキソ-カルノシンはカルノシンの抗酸化活性の本体か?

居原 秀, 笠松 真吾, 垣花 優希, 小前 奏明, 松倉 加奈, 内田 浩二

日本栄養・食糧学会大会講演要旨集  2021.07  (公社)日本栄養・食糧学会

超硫黄分子メタボロミクス Invited Domestic conference

居原

第1回レドックスR&D戦略委員会シンポジウム  2021.03 

2-オキソーイミダゾールジペプチドの抗酸化活性 Invited Domestic conference

居原

日本農芸化学会２０２0年度大会  2021.03 

硫黄メタボローム解析の先端技術開発 Invited Domestic conference

居原

第20回日本NO学会/第73回日本酸化ストレス学会合同学会  2020.10 

アルツハイマー病と活性硫黄代謝系の連関の解析 Domestic conference

居原ら

第20回日本NO学会/第73回日本酸化ストレス学会合同学会  2020.10 

2-オキソ-カルノシンの抗炎症効果 Domestic conference

居原ら

第20回日本NO学会/第74回日本酸化ストレス学会合同学会  2020.10 

タンパク質活性硫黄の選択的検出系の開発 Domestic conference

居原ら

第20回日本NO学会/第76回日本酸化ストレス学会合同学会  2020.10 

活性イオウ分子種特異的新規アルキル化試薬の合成 Domestic conference

居原ら

第20回日本NO学会/第76回日本酸化ストレス学会合同学会  2020.10 

新規アルキル化剤を用いた活性イオウ分子種の網羅的検出 Domestic conference

居原ら

第20回日本NO学会/第76回日本酸化ストレス学会合同学会  2020.10 

硫黄解析の先端技術開発 Invited Domestic conference

居原

第93回日本生化学会大会  2020.09 

2-オキソ-イミダゾールジペプチドは内在性の強力な抗酸化物質である Domestic conference

居原ら

第74回日本栄養・食糧学会大会  2020.09 

硫黄の化学的理解に立脚したカルコゲン・バイオロジー　硫黄解析の先端技術開発

居原 秀

日本生化学会大会プログラム・講演要旨集  2020.09  (公社)日本生化学会

活性硫黄による親電子ストレス制御 Invited Domestic conference

居原

第47回日本毒性学会学術年会  2020.06 

硫黄代謝研究の最前線が切り拓く毒性学　活性硫黄による親電子ストレス制御

居原 秀

The Journal of Toxicological Sciences  2020.06  (一社)日本毒性学会

酸化イミダゾールジペプチドによる細胞機能調節

垣花 優希, 笠松 真吾, 内田 浩二, 居原 秀

日本栄養・食糧学会大会講演要旨集  2020.04  (公社)日本栄養・食糧学会

2-オキソ-イミダゾールジペプチドは内在性の強力な抗酸化物質である

居原 秀, 垣花 優希, 内田 浩二

日本栄養・食糧学会大会講演要旨集  2020.04  (公社)日本栄養・食糧学会

細菌のタンパク質翻訳共役型システインパースルフィド合成機構の解明 Domestic conference

居原ら

第93回日本細菌学会総会  2020.03 

新規の抗酸化物質2-オキソ-カルノシンによる細胞機能調節 Domestic conference

居原ら

第19回分子予防環境医学研究会大会  2020.03 

レドックスシグナルを介した神経毒性の調節機構 Domestic conference

居原ら

第19回分子予防環境医学研究会大会  2020.03 

1-Methyl-4-phenylpyridinium ion神経毒性における一酸化窒素/活性酸素種レドックスシグナル経路の関与 Domestic conference

居原ら

第19回分子予防環境医学研究会大会  2020.03 

ホモアンセリンおよび酸化ホモアンセリンの測定方法の確立と生体内局在の解明 Domestic conference

居原ら

日本農芸化学会2020年度大会  2020.03 

培地中の硫酸塩がユーグレナの活性イオウ分子の生成動態に及ぼす影響 Domestic conference

居原ら

日本農芸化学会2020年度大会  2020.03 

2-オキソ-イミダゾールジペプチドの抗酸化活性 Domestic conference

居原ら

日本農芸化学会2020年度大会  2020.03 

食品中の活性硫黄の定量解析 Domestic conference

居原ら

日本農芸化学会2020年度大会  2020.03 

新規のレドックスアミノ酸；システインパースルフィド、オキソヒスチジン Invited Domestic conference

居原

脳内アミノ酸代謝研究会  2020.01 

細菌のタンパク質翻訳共役型システインパースルフィド合成機構の解明

松永 哲郎, 井田 智章, 西村 明, ジョン・ミンギョン , 守田 匡伸, 澤 智裕, 居原 秀, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌  2020.01  日本細菌学会

活性イオウ分子による親電子シグナル制御系の破綻に起因する有機水銀の神経毒性発現機構 Domestic conference

居原ら

メタルバイオサイエンス研究会2019  2019.10 

Disruption of reactive persulfide-dependent redox signal by exposure of electrophile in neuronal cells International conference

Ihara et al

Persulfide Conference 2019 (1st International Conference on Persulfides and Sulfur Metabolism in Biology and Medicine)  2019.09 

活性イオウメタボロームの開発と応用展開 Domestic conference

居原ら

第92回日本生化学会大会  2019.09 

生体エネルギーと電子共役の複雑性制御　活性イオウメタボロームの開発と応用展開

居原 秀

日本生化学会大会プログラム・講演要旨集  2019.09  (公社)日本生化学会

活性イオウ安定化と高精度イオウ代謝解析法の確立

井田 智章, 松永 哲郎, 西村 明, 守田 匡伸, 居原 秀, 澤 智裕, 本橋 ほづみ, 赤池 孝章

日本生化学会大会プログラム・講演要旨集  2019.09  (公社)日本生化学会

新規の機能性物質2-オキソイミダゾールジペプチドの発見 Invited Domestic conference

居原

日本プロテオーム学会2019年大会 第70回日本電気泳動学会総会  2019.07 

生体成分のレドックス修飾と機能解析　新規の機能性物質2-オキソイミダゾールジペプチドの発見

居原 秀

電気泳動  2019.07  日本電気泳動学会

アルツハイマー病およびてんかんモデルマウスにおける8-nitro-cGMP産生と神経活動への影響 Domestic conference

居原他

第19回日本NO学会学術集会  2019.06 

腸管出血性大腸菌毒素SubABによる自然免疫抑制を介した病原性発現機構の解析 Domestic conference

居原ら

第19回日本NO学会学術集会  2019.06 

活性イオウ構造保護を目的とした新規アルキル化剤の作製 Domestic conference

居原ら

第72回 日本酸化ストレス学会学術集会  2019.06 

大豆タンパク質中の活性イオウの解析 Domestic conference

居原ら

第72回日本酸化ストレス学会学術集会  2019.06 

酸化イミダゾールジペプチドは新規内在性抗酸化物質である Domestic conference

居原ら

第72回日本酸化ストレス学会学術集会  2019.06 

全生物種横断的に発現されるシステインパースルフィド合成酵素の発見と機能解明

井田 智章, 守田 匡伸, 松永 哲郎, 西村 明, 居原 秀, 澤 智裕, 本橋 ほづみ, 赤池 孝章

日本細菌学雑誌  2019.03  日本細菌学会

病態生物化学特論

2024   Weekly class   Graduate school

生物化学特別研究2A

2024   Intensive lecture   Graduate school

生物化学特別研究1A

2024   Intensive lecture   Graduate school

生物化学特別演習2A

2024   Intensive lecture   Graduate school

生物化学特別演習1A

2024   Intensive lecture   Graduate school

生物化学への招待

2024   Weekly class   Graduate school

生物化学特別講義F

2024   Intensive lecture   Graduate school

生物化学特別研究5A

2024   Intensive lecture   Graduate school

生物化学特別研究4A

2024   Intensive lecture   Graduate school

生物化学特別研究3A

2024   Intensive lecture   Graduate school

生物化学特別演習5A

2024   Intensive lecture   Graduate school

生物化学特別演習4A

2024   Intensive lecture   Graduate school

生物化学特別演習3A

2024   Intensive lecture   Graduate school

細胞生物学I

2024   Intensive lecture   Undergraduate

Cell biology

2021    

Biochemistry II

2021    

Experiment in Biological Science II

2021   Practical Training  

Instrumental Analysis in Biology

2021    

Cell Biology I

2021    

Molecular Biology II

2021