Updated on 2024/04/08
Graduate School of Veterinary Science Department of Veterinary Science
Professor 2022.04 - Now
School of Veterinary Science Department of Veterinary Science
Professor 2022.04 - Now
博士（獣医学） （ Others ）
Life Science / Veterinary medical science / Veterinary Physiology
正常時および病態時のアミノ酸代謝変化
シトリン欠損症の病態解明と治療法の開発
アミノ酸代謝、尿素サイクル、臓器相関、臓器灌流 International Joint Research
2000.04 - Now
病態時におけるグリア細胞の代謝変化
International Joint Research
2006.07 - Now
日本神経化学会
2009.01 - Now Domestic
日本生理学会
1995.04 - Now Domestic
日本生化学会
1991.04 - Now Domestic
日本獣医学会
1990.04 - Now Domestic
Takano-Kawabe K. Minamihata T. Moriyama M.
Current Molecular Pharmacology 17 2024.02（ ISSN:18744672 ）
Takano-Kawabe K. Minamihata T. Moriyama M.
Neurochemical Research 49 ( 1 ) 199 - 211 2024.01（ ISSN:03643190 ）
Increase in cellular lysophosphatidylserine content exacerbates inflammatory responses in LPS-activated microglia. Reviewed
Minamihata T, Takano K, Nakamura Y, Seto R, Moriyama M.
Neurochemical Research 2022
Acetate suppresses lipopolysaccharide-stimulated nitric oxide production in primary rat microglia but not in BV-2 microglia cells. Reviewed
Moriyama M, Nishimura Y, Kurebayashi R, Minamihata T, Kawabe K, Takano K Nakamura Y.
Curr. Mol. Pharmacol. 雑誌 14 253 - 260 2021
Lysophosphatidylinositol, an endogenous ligand for G protein-coupled receptor 55, has anti-inflammatory effects in cultured microglia. Reviewed
Minamihata T, Moriyama M*, Takano K, Nakamura Y
Inflammation 雑誌 43 1971 - 1987 2020
AGC2 (Citrin) deficiency-From recognition of the disease till construction of therapeutic procedures. Reviewed
Saheki T, Moriyama M, Funahashi A, Kuroda E.
Biomolecules 雑誌 10 ( 8 ) 2020
Pivotal role of inter-organ aspartate metabolism for the treatment of citrin deficiency, based on the mouse model. Reviewed
Saheki T, Moriyama M, Kuroda E, Funahashi A, Yasuda I, Setogawa Y, Gao Q, Ushikai M, Furuie S, Yamamura KI, Takano K, Nakamura Y, Eto K, Kadowaki T, Sinasac DS, Furukawa T, Horiuchi M, Tai YH.
Scientific Reports ( 9 ) 2019.03
A dibenzoylmethane derivative inhibits lipopolysaccharide-induced NO production in mouse microglial cell line BV-2. Reviewed
Takano K, Ishida N, Kawabe K, Moriyama M, Hibino S, Choshi T, Hori O, Nakamura Y.
Neurochemistry International 119 126 - 131 2018.10
Insulin expression in cultured astrocytes and the decrease by amyloid beta. Reviewed
Takano K, Koarashi K, Kawabe K, Itakura M, Nakajima H, Moriyama M, Nakamura Y.
Neurochemistry International 119 171 - 177 2018.10
Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPR40-dependent pathway.
Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Nakamura Y.
Neurochemical Research 43 1723 - 1735 2018.09
S-Equol, a major isoflavone from soybean, inhibits nitric oxide production in lipopolysaccharide-stimulated rat astrocytes partially via the GPR30-mediated pathway Reviewed
Moriyama M, Hashimoto, A, Satoh H, Kawabe K, Takano K, Nakamura Y.
International Journal of Inflammation 8496973 2018.03
Inhibition of gap junction elevates glutamate uptake in cultured astrocytes.
Takano K, Ogawa M, Kawabe K, Moriyama M, Nakamura Y.
Neurochemical Research 43 50 - 56 2018.02
Zinc potentiates lipopolysaccharide-induced nitric oxide production in cultured primary rat astrocytes. Reviewed
Moriyama M, Fujitsuka, S, Kawabe K, Takano K, Nakamura Y.
Neurochemical Research 43 363 - 374 2018.02
Microglia endocytose amyloid β through the binding of transglutaminase 2 and milk fat globule EGF factor 8 protein. Reviewed
Kawabe K, Takano K, Moriyama M, Nakamura Y.
Neurochemical Research 43 32 - 40 2018.01
Mechanism for increased hepatic glycerol synthesis in the citrin/mitochondrial glycerol-3-phosphate dehydrogenase double-knockout mouse: Urine glycerol and glycerol 3-phosphate as potential diagnostic markers of human citrin deficiency Reviewed
Moriyama M, Fujimoto Y, Rikimaru S, Ushikai M, Kuroda E, Kawabe K, Takano K, Asakawa A, Inui A, Eto K, Kadowaki T, Sinasac D. S., Okano Y, Yazaki M, Ikeda S-I, Zhang C, Song Y-Z, Sakamoto O, Kure S, Mitsubuchi H, Endo F, Horiuchi M, Nakamura Y, Yamamura K-I, Saheki T.
Biochim. Biophys. Acta 雑誌 1852 1787 - 1795 2015
Extracellular superoxide dismutase in cultured astrocytes: decrease in cell-surface activity and increase in medium activity by lipopolysaccharide-stimulation. Reviewed
Iitsuka I, Motoyoshi-Yamashiro A, Moriyama M, Kannan-Hayashi Y, Fujimoto Y, Takano K, Murakami K, Yoneda Y, Nakamura Y.
Neurochem. Res. 雑誌 37 2108 - 2116 2012
A dibenzoylmethane derivative protects H2O2-induced cell death and inhibits lipopolysaccharide-induced NO production in cultured rat astrocytes. Reviewed
Takano, K., Sugita, K., Moriyama, M., Hashida, K., Hibino, S., Choshi, T., Murakami, R., Yamada, M., Suzuki, H., Hori, O., Nakamura Y.
J. Neurosci. Res 雑誌 89 955 - 965 2011.06
Roles of mitogen-activated protein kinases in the mechanism of oxidant-induced cell swelling in cultured astrocytes. Reviewed
Moriyama M, Tong XY, Jayakumar AR, Norenberg MD.
J. Neurosci. Res. 雑誌 88 2450 - 2458 2010.08
Pyruvate ameliorates the defect in ureogenesis from ammonia in citrin-deficient mice. Reviewed
Moriyama M, Li MX, Kobayashi K, Sinasac DS, Kannan Y, Iijima M, Horiuchi M, Tsui LC, Tanaka M, Nakamura Y, Saheki T.
J. Hepatol. 雑誌 Vol. 44 930 - 938 2006.05
Decreased ureagenesis from alanine, but not from ammonia and glutamine, in the perfused rat liver after partial hepatectomy. Reviewed
Moriyama. M, Makiyama. I, Shiota. M, Uesugi. K, Kannan. Y, Ohta. M, Kimura. K, Sugano. T.
Hepatology 雑誌 Vol. 23 1584 - 1590 1996.06
シトリン欠損症の分子病態と生化学的マーカー
佐伯武頼, 森山光章（ Role： Joint author）
科学評論社 2017.07
実験で学ぶ生理学[改訂版] 肝機能の評価ー肝臓灌流実験ー
森山光章（ Role： Sole author）
学窓社 2014.02
Pathophysiology of citrin deficiency.
Saheki T, Kobayashi K, Li MX, Horiuchi M, Tabata A, Lu YB, Ushikai M, Terashi M, Moriyama M.（ Role： Joint author）
2006.07
臓器灌流実験講座 再生肝のフルクトース代謝と脂肪酸による調節
森山光章 菅野司（ Role： Joint author）
新興医学出版社 2000.03
Sphingosine kinase 1 inhibition aggravates neuronal damage in neuron/glia mixed culture via reduced microglial Aβ uptake.
Minamihata T, Takano K, Moriyama M.
2023.06
Effect of sphingosine kinase 1 inhibition on sphingolipid metabolic pathway and inflammatory responses in microglia International conference
Minamihata T, Takano K, Moriyama M.
Neuro 2022 2022.07
Increase in intracellular lysophosphatidylserine content exacerbates inflammatory response by cultured microglia. Domestic conference
Tomoki Minamihata, Katsura Takano, Mitsuaki Moriyama and Yoichi Nakamura
第64回神経化学会大会 2021.09
Lysophosphatidylinositol suppressed inflammatory responses by cultured microglia Domestic conference
Minamihata, T., Moriyama, M., Takano, K., Nakamura, Y.
第63回日本神経化学会 2020.09
シトリン欠損症における高アンモニア血症に対するMCTの作用点
佐伯 武頼, 舟橋 亞希, 黒田 英志, 安田 いづみ, 高 青華, 瀬戸川 芳子, 牛飼 美晴, 堀内 正久, 森山 光章
日本先天代謝異常学会雑誌 2019.09 (一社)日本先天代謝異常学会
シトリン欠損症モデルマウス灌流肝を用いたアンモニアからの尿素生成に対する中鎖脂肪酸の効果
森山 光章, 黒田 英志, 舟橋 亞希, 安田 いづみ, 高 青華, 瀬戸川 芳子, 牛飼 美晴, 堀内 正久, 佐伯 武頼
日本先天代謝異常学会雑誌 2019.09 (一社)日本先天代謝異常学会
シトルリン血症治療剤 (Na-Pyr)
森山光章, 佐伯武頼, 田中雅嗣, 小林圭子
短鎖および中鎖脂肪酸による神経炎症の制御
Grant-in-Aid for Scientific Research(C) 2022
短鎖および中鎖脂肪酸による神経炎症の制御
Grant-in-Aid for Scientific Research(C) 2021
短鎖および中鎖脂肪酸による神経炎症の制御
Grant-in-Aid for Scientific Research(C) 2020
外傷性脳損傷におけるインフラマソームの役割の解明とその制御に基づいた治療薬の開発
Grant-in-Aid for Scientific Research(C) 2019
外傷性脳損傷におけるインフラマソームの役割の解明とその制御に基づいた治療薬の開発
Grant-in-Aid for Scientific Research(C) 2018
外傷性脳損傷におけるインフラマソームの役割の解明とその制御に基づいた治療薬の開発
Grant-in-Aid for Scientific Research(C) 2017
シトリン欠損症におけるCTLN2発症・重篤化に関わる遺伝因子・環境因子の解明
Grant-in-Aid for Scientific Research(C) 2017
シトリン欠損症におけるCTLN2発症・重篤化に関わる遺伝因子・環境因子の解明
Grant-in-Aid for Scientific Research(C) 2016
外傷性脳損傷時のグリア細胞の役割－グリア細胞をターゲットとした神経保護薬の探索－
2016
シトリン欠損症におけるCTLN2発症・重篤化に関わる遺伝因子・環境因子の解明
Grant-in-Aid for Scientific Research(C) 2015
外傷性脳損傷時のグリア細胞の役割－グリア細胞をターゲットとした神経保護薬の探索－
Grant-in-Aid for Scientific Research(C) 2015
外傷性脳損傷時のグリア細胞の役割ーグリア細胞をターゲットとした神経保護薬の探索−
Grant-in-Aid for Scientific Research(C) 2014
外傷性脳損傷時のグリア細胞の役割－グリア細胞をターゲットとした神経保護薬の探索－
Grant-in-Aid for Scientific Research(C) 2014
アストロサイト膨潤の分子基盤に基づいた新規脳浮腫治療薬の開発
Grant-in-Aid for Scientific Research(C) 2013
アストロサイト膨潤の分子基盤に基づいた新規脳浮腫治療薬の開発
Grant-in-Aid for Scientific Research(C) 2012
アストロサイト膨潤の分子基盤に基づいた新規脳浮腫治療薬の開発
Grant-in-Aid for Scientific Research(C) 2011
アストロサイト膨潤の分子基盤に基づいた新規脳浮腫治療薬の開発
Grant-in-Aid for Scientific Research(C) 2011
シトリン欠損症治療へのピルビン酸ナトリウムの応用
2010
糖尿病ラットにおけるKupffer細胞および好中球の機能に関する研究
Grant-in-Aid for Scientific Research(C) 2001
糖尿病ラットにおけるKupffer細胞および好中球の機能に関する研究
Grant-in-Aid for Scientific Research(C) 2000
糖尿病ラットにおけるKupffer細胞および好中球の機能に関する研究
Grant-in-Aid for Scientific Research(C) 1999
酢酸の新規作用の探索-中枢炎症性変化に対する抑制効果-
一般財団法人旗影会 2015
主に獣医生理学を担当。
獣医生理学A
2023 Weekly class Undergraduate
獣医生理学B
2023 Weekly class Undergraduate
獣医生理学実習
2023 Weekly class Undergraduate
基礎動物生理学
2023 Weekly class Undergraduate
獣医学概論
2023 Intensive lecture Undergraduate
獣医科学特別研究1
2023 Intensive lecture Graduate school
獣医生理学実習
2023 Weekly class Undergraduate
小動物基礎臨床実習
2023 Intensive lecture Undergraduate
病態機能学特論
2023 Intensive lecture Graduate school
統合バイオ機能学特別講義A
2023 Intensive lecture Graduate school
臨床基礎実習
2023 Weekly class Undergraduate
獣医生理学C
2023 Weekly class Undergraduate
獣医生理学A
2023 Intensive lecture Undergraduate
生物学B
2023 Weekly class Undergraduate
生物学実験
2023 Intensive lecture Undergraduate
生物学A
2023 Intensive lecture Undergraduate
獣医科学特別演習1
2023 Intensive lecture Graduate school
獣医科学ミニレビュー
2023 Intensive lecture Graduate school
獣医科学演習
2023 Intensive lecture Undergraduate
国際・国内インターンシップ
2023 Intensive lecture Graduate school
獣医体験演習
2023 Weekly class Undergraduate
小動物基礎臨床実習
2022 Intensive lecture Undergraduate
獣医生理学実習
2022 Weekly class Undergraduate
獣医生理学C
2022 Weekly class Undergraduate
獣医生理学A
2022 Weekly class Undergraduate
初年次ゼミナール
2022 Weekly class Undergraduate
動物構造機能学特別講義A
2022 Intensive lecture Graduate school
獣医科学特別演習1
2022 Intensive lecture Graduate school
統合バイオ機能学特別講義A
2022 Intensive lecture Graduate school
動物構造機能学特別講義
2022 Intensive lecture Graduate school
獣医科学特別演習1
2022 Intensive lecture Graduate school
獣医科学特別研究1
2022 Intensive lecture Graduate school
基礎動物生理学
2022 Weekly class Undergraduate
臨床基礎実習
2022 Weekly class Undergraduate
獣医生理学A
2022 Weekly class Undergraduate
獣医体験演習
2022 Weekly class Undergraduate
生物学B
2022 Intensive lecture Undergraduate
獣医生理学B
2022 Weekly class Undergraduate
国際・国内インターンシップ
2022 Intensive lecture Graduate school
生物学A
2022 Intensive lecture Graduate school
生物学実験
2022 Intensive lecture Graduate school
生命環境科学入門
2022 Weekly class Graduate school
Special Lecture: Integrated Functional Biosciences A
2021
Practice in Veterinary Physiology
2021 Practical Training
Biology A
2021
Veterinary Physiology A
2021
Fundamental Experiments of Biology
2021 Practical Training
Veterinary Physiology C
2021
Animal Physiology on Basic
2021
Veterinary Physiology B
2021
Introduction to Life, Environment, and Advanced Sciences
2021
Biology B
2021
Basic clinical practices
2021 Practical Training
2023
Number of graduate students presentations：1
2022
Number of graduate students presentations：1
2021
Number of graduate students presentations：1
2020
Number of graduate students presentations：1
2023
Number of instructed the graduation thesis：2 Number of graduation thesis reviews：5
[Number of instructed the Master's Program] (letter term)：1
[Number of doctoral thesis reviews] (chief)：1 [Number of doctoral thesis reviews] (vice-chief)：5
2022
Number of instructed the graduation thesis：2 Number of graduation thesis reviews：4
[Number of instructed the Master's Program] (previous term)：0 [Number of instructed the Master's Program] (letter term)：1
[Number of master's thesis reviews] (chief)：0 [Number of master's thesis reviews] (vice-chief)：0
[Number of doctoral thesis reviews] (chief)：0 [Number of doctoral thesis reviews] (vice-chief)：3
2021
Number of instructed the graduation thesis：2
Job title within the department
Graduate School of Veterinary Science
副研究院長 2024.04
Job title within the department
Graduate School of Veterinary Science
副研究科長 2024.04
Job title within the department
School of Veterinary Science
副学部長 2024.04