Updated on 2024/03/20

写真a

 
Akiyama Kohki
 
Organization
Graduate School of Agriculture Department of Applied Biological Chemistry Professor
School of Agriculture Department of Applied Biological Chemistry
Title
Professor
Affiliation
Institute of Agriculture
Affiliation campus
Nakamozu Campus

Position

  • Graduate School of Agriculture Department of Applied Biological Chemistry 

    Professor  2022.04 - Now

  • School of Agriculture Department of Applied Biological Chemistry 

    Professor  2022.04 - Now

Degree

  • 農学博士 （ Others ）

Research Areas

  • Life Science / Bioorganic chemistry  / Natural products chemistry

  • Life Science / Bioorganic chemistry

Research Interests

  • 菌根共生

  • strigolactone

  • キトオリゴ糖

  • arbuscular mycorrhizal fungi

Research subject summary

  • アーバスキュラー菌根菌と植物との共生系における共生制御物質の解明

Research Career

  • アーバスキュラー菌根菌と植物との共生系における共生制御物質の解明

    アーバスキュラー菌根菌、共生、ミヤコグサ、シグナル物質 

    1996.07 - Now 

Professional Memberships

  • 日本農芸化学会

    1990.03 - Now

  • 植物化学調節学会

    1990.10 - Now

  • 植物微生物研究会

    2002.10 - Now

Awards

  • 植物化学調節学会賞

    2016.10   植物化学調節学会  

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    Country：Japan

  • 第3回リサーチフロントアワード

    2012.02   トムソン・ロイター  

  • 平成18年度　農芸化学奨励賞

    2006.03   日本農芸化学会  

  • 平成18年度　B.B.B.論文賞（共著）

    2006.03   日本農芸化学会  

Papers

  • Canonical strigolactones are not the major determinant of tillering but important rhizospheric signals in rice.

    Shinsaku Ito, Justine Braguy, Jian You Wang, Akiyoshi Yoda, Valentina Fiorilli, Ikuo Takahashi, Muhammad Jamil, Abrar Felemban, Sho Miyazaki, Teresa Mazzarella, Guan-Ting Erica Chen, Akihisa Shinozawa, Aparna Balakrishna, Lamis Berqdar, Chakravarty Rajan, Shawkat Ali, Imran Haider, Yasuyuki Sasaki, Shunsuke Yajima, Kohki Akiyama, Luisa Lanfranco, Matias D Zurbriggen, Takahito Nomura, Tadao Asami, Salim Al-Babili

    Science advances   8 ( 44 )   eadd1278   2022.11

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Strigolactones (SLs) are a plant hormone inhibiting shoot branching/tillering and a rhizospheric, chemical signal that triggers seed germination of the noxious root parasitic plant Striga and mediates symbiosis with beneficial arbuscular mycorrhizal fungi. Identifying specific roles of canonical and noncanonical SLs, the two SL subfamilies, is important for developing Striga-resistant cereals and for engineering plant architecture. Here, we report that rice mutants lacking canonical SLs do not show the shoot phenotypes known for SL-deficient plants, exhibiting only a delay in establishing arbuscular mycorrhizal symbiosis, but release exudates with a significantly decreased Striga seed-germinating activity. Blocking the biosynthesis of canonical SLs by TIS108, a specific enzyme inhibitor, significantly lowered Striga infestation without affecting rice growth. These results indicate that canonical SLs are not the determinant of shoot architecture and pave the way for increasing crop resistance by gene editing or chemical treatment.

    DOI： 10.1126/sciadv.add1278

    PubMed

  • An ancestral function of strigolactones as symbiotic rhizosphere signals Reviewed International coauthorship

    Kyoichi Kodama, Mélanie K. Rich, Akiyoshi Yoda, Shota Shimazaki, Xiaonan Xie, Kohki Akiyama, Yohei Mizuno, Aino Komatsu, Yi Luo, Hidemasa Suzuki, Hiromu Kameoka, Cyril Libourel, Jean Keller, Keiko Sakakibara, Tomoaki Nishiyama, Tomomi Nakagawa, Kiyoshi Mashiguchi, Kenichi Uchida, Kaori Yoneyama, Yoshikazu Tanaka, Shinjiro Yamaguchi, Masaki Shimamura, Pierre-Marc Delaux, Takahito Nomura, Junko Kyozuka

    Nature Communications   13 ( 1 )   3974   2022.07

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1038/s41467-022-31708-3

  • Strigolactones Modulate Salicylic Acid-Mediated Disease Resistance in Arabidopsis thaliana Reviewed

    Miyuki Kusajima, Moeka Fujita, Khamsalath Soudthedlath, Hidemitsu Nakamura, Koichi Yoneyama, Takahito Nomura, Kohki Akiyama, Akiko Maruyama-Nakashita, Tadao Asami, Hideo Nakashita

    International Journal of Molecular Sciences   23 ( 9 )   5246 - 5246   2022.05（ eISSN:1422-0067 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Strigolactones are low-molecular-weight phytohormones that play several roles in plants, such as regulation of shoot branching and interactions with arbuscular mycorrhizal fungi and parasitic weeds. Recently, strigolactones have been shown to be involved in plant responses to abiotic and biotic stress conditions. Herein, we analyzed the effects of strigolactones on systemic acquired resistance induced through salicylic acid-mediated signaling. We observed that the systemic acquired resistance inducer enhanced disease resistance in strigolactone-signaling and biosynthesis-deficient mutants. However, the amount of endogenous salicylic acid and the expression levels of salicylic acid-responsive genes were lower in strigolactone signaling-deficient max2 mutants than in wildtype plants. In both the wildtype and strigolactone biosynthesis-deficient mutants, the strigolactone analog GR24 enhanced disease resistance, whereas treatment with a strigolactone biosynthesis inhibitor suppressed disease resistance in the wildtype. Before inoculation of wildtype plants with pathogenic bacteria, treatment with GR24 did not induce defense-related genes; however, salicylic acid-responsive defense genes were rapidly induced after pathogenic infection. These findings suggest that strigolactones have a priming effect on Arabidopsis thaliana by inducing salicylic acid-mediated disease resistance.

    DOI： 10.3390/ijms23095246

    PubMed

  • Response of tomatoes primed by mycorrhizal colonization to virulent and avirulent bacterial pathogens Reviewed

    Moeka Fujita, Miyuki Kusajima, Masatomo Fukagawa, Yasuko Okumura, Masami Nakajima, Kohki Akiyama, Tadao Asami, Koichi Yoneyama, Hisaharu Kato, Hideo Nakashita

    Scientific Reports   12 ( 1 )   4686   2022.03

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1038/s41598-022-08395-7

  • A carlactonoic acid methyltransferase that contributes to the inhibition of shoot branching in Arabidopsis Reviewed International coauthorship

    Kiyoshi Mashiguchi, Yoshiya Seto, Yuta Onozuka, Sarina Suzuki, Kiyoko Takemoto, Yanting Wang, Lemeng Dong, Kei Asami, Ryota Noda, Takaya Kisugi, Naoki Kitaoka, Kohki Akiyama, Harro Bouwmeester, Shinjiro Yamaguchi

    Proceedings of the National Academy of Sciences   119 ( 14 )   2111565119   2022.03

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1073/pnas.2111565119

  • Asymbiotic mass production of the arbuscular mycorrhizal fungus Rhizophagus clarus Reviewed

    Sachiko Tanaka, Kayo Hashimoto, Yuuki Kobayashi, Koji Yano, Taro Maeda, Hiromu Kameoka, Tatsuhiro Ezawa, Katsuharu Saito, Kohki Akiyama, Masayoshi Kawaguchi

    Communications Biology   5 ( 1 )   43   2022.01

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1038/s42003-021-02967-5

  • Strigolactone biosynthesis catalyzed by cytochrome P450 and sulfotransferase in sorghum Reviewed International coauthorship

    Akiyoshi Yoda, Narumi Mori, Kohki Akiyama, Mayu Kikuchi, Xiaonan Xie, Kenji Miura, Kaori Yoneyama, Kanna Sato‐Izawa, Shinjiro Yamaguchi, Koichi Yoneyama, David C Nelson, Takahito Nomura

    New Phytologist   232 ( 5 )   1999 - 2010   2021.12

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1111/nph.17737

  • Strigolactone biosynthesis catalyzed by cytochrome P450 and sulfotransferase in sorghum Reviewed

    Akiyoshi Yoda, Narumi Mori, Kohki Akiyama, Mayu Kikuchi, Xiaonan Xie, Kenji Miura, Kaori Yoneyama, Kanna Sato‐Izawa, Shinjiro Yamaguchi, Koichi Yoneyama, David C. Nelson, Takahito Nomura

    New Phytologist   232 ( 5 )   1999 - 2010   2021.12（ ISSN:0028-646X ） （ eISSN:1469-8137 ）

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    Publishing type：Research paper (scientific journal)  

    Root parasitic plants such as Striga, Orobanche, and Phelipanche spp. cause serious damage to crop production world-wide. Deletion of the Low Germination Stimulant 1 (LGS1) gene gives a Striga-resistance trait in sorghum (Sorghum bicolor). The LGS1 gene encodes a sulfotransferase-like protein, but its function has not been elucidated. Since the profile of strigolactones (SLs) that induce seed germination in root parasitic plants is altered in the lgs1 mutant, LGS1 is thought to be an SL biosynthetic enzyme. In order to clarify the enzymatic function of LGS1, we looked for candidate SL substrates that accumulate in the lgs1 mutants and performed in vivo and in vitro metabolism experiments. We found the SL precursor 18-hydroxycarlactonoic acid (18-OH-CLA) is a substrate for LGS1. CYP711A cytochrome P450 enzymes (SbMAX1 proteins) in sorghum produce 18-OH-CLA. When LGS1 and SbMAX1 coding sequences were co-expressed in Nicotiana benthamiana with the upstream SL biosynthesis genes from sorghum, the canonical SLs 5-deoxystrigol and 4-deoxyorobanchol were produced. This finding showed that LGS1 in sorghum uses a sulfo group to catalyze leaving of a hydroxyl group and cyclization of 18-OH-CLA. A similar SL biosynthetic pathway has not been found in other plant species.

    DOI： 10.1111/nph.17737

    Other URL： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/nph.17737

  • Myristate can be used as a carbon and energy source for the asymbiotic growth of arbuscular mycorrhizal fungi Reviewed

    Yuta Sugiura, Rei Akiyama, Sachiko Tanaka, Koji Yano, Hiromu Kameoka, Shiori Marui, Masanori Saito, Masayoshi Kawaguchi, Kohki Akiyama, Katsuharu Saito

    Proceedings of the National Academy of Sciences   117 ( 41 )   25779 - 25788   2020.10（ ISSN:0027-8424 ） （ eISSN:1091-6490 ）

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    Publishing type：Research paper (scientific journal)  

    Significance

    The origins of arbuscular mycorrhizal (AM) fungi, which form symbiotic associations with land plants, date back >460 Mya. During evolution, these fungi acquired an obligate symbiotic lifestyle, and thus depend on their host for essential nutrients. In particular, fatty acids are regarded as crucial nutrients for the survival of AM fungi, owing to the absence of genes involved in de novo fatty acid biosynthesis in the AM fungal genomes that have been sequenced so far. Here we show that myristate initiates AM fungal growth under asymbiotic conditions. These findings will advance the pure culture of AM fungi.

    DOI： 10.1073/pnas.2006948117

    PubMed

    Other URL： https://pnas.org/doi/pdf/10.1073/pnas.2006948117

  • Chemical identification of 18-hydroxycarlactonoic acid as an LjMAX1 product and in planta conversion of its methyl ester to canonical and non-canonical strigolactones in Lotus japonicus Reviewed

    Narumi Mori, Aika Sado, Xiaonan Xie, Kaori Yoneyama, Kei Asami, Yoshiya Seto, Takahito Nomura, Shinjiro Yamaguchi, Koichi Yoneyama, Kohki Akiyama

    Phytochemistry   174   112349 - 112349   2020.06（ ISSN:0031-9422 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    © 2020 Elsevier Ltd Strigolactones (SLs) are a group of plant apocarotenoids that act as rhizosphere signaling molecules for both arbuscular mycorrhizal fungi and root parasitic plants. They also regulate plant architecture as phytohormones. The model legume Lotus japonicus (synonym of Lotus corniculatus) produces canonical 5-deoxystrigol (5DS) and non-canonical lotuslactone (LL). The biosynthesis pathways of the two SLs remain elusive. In this study, we characterized the L. japonicus MAX1 homolog, LjMAX1, found in the Lotus japonicus genome assembly build 2.5. The L. japonicus max1 LORE1 insertion mutant was deficient in 5DS and LL production. A recombinant LjMAX1 protein expressed in yeast microsomes converted carlactone (CL) to 18-hydroxycarlactonoic acid (18-OH-CLA) via carlactonoic acid (CLA). Identity of 18-OH-CLA was confirmed by comparison of the methyl ester derivative of the MAX1 product with chemically synthesized methyl 18-hydroycarlactonoate (18-OH-MeCLA) using LC-MS/MS. (11R)-CL was detected as an endogenous compound in the root of L. japonicus. 13C-labeled CL, CLA, and 18-OH-MeCLA were converted to [13C]-5DS and LL in plant feeding experiments using L. japonicus WT. These results showed that LjMAX1 is the crucial enzyme in the biosynthesis of Lotus SLs and that 18-hydroxylated carlactonoates are possible precursors for SL biosynthesis in L. japonicus.

    DOI： 10.1016/j.phytochem.2020.112349

    PubMed

  • Hydroxyl carlactone derivatives are predominant strigolactones in Arabidopsis Reviewed

    Kaori Yoneyama, Kohki Akiyama, Philip B. Brewer, Narumi Mori, Miyuki Kawano-Kawada, Shinsuke Haruta, Hisashi Nishiwaki, Satoshi Yamauchi, Xiaonan Xie, Mikihisa Umehara, Christine A. Beveridge, Koichi Yoneyama, Takahito Nomura

    Plant Direct   4 ( 5 )   e00219   2020.05（ eISSN:2475-4455 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    © 2020 The Authors. Plant Direct published by American Society of Plant Biologists and the Society for Experimental Biology and John Wiley & Sons Ltd Strigolactones (SLs) regulate important aspects of plant growth and stress responses. Many diverse types of SL occur in plants, but a complete picture of biosynthesis remains unclear. In Arabidopsis thaliana, we have demonstrated that MAX1, a cytochrome P450 monooxygenase, converts carlactone (CL) into carlactonoic acid (CLA) and that LBO, a 2-oxoglutarate-dependent dioxygenase, can convert methyl carlactonoate (MeCLA) into a metabolite called [MeCLA + 16 Da]. In the present study, feeding experiments with deuterated MeCLAs revealed that [MeCLA + 16 Da] is hydroxymethyl carlactonoate (1'-HO-MeCLA). Importantly, this LBO metabolite was detected in plants. Interestingly, other related compounds, methyl 4-hydroxycarlactonoate (4-HO-MeCLA) and methyl 16-hydroxycarlactonoate (16-HO-MeCLA), were also found to accumulate in lbo mutants. 3-HO-, 4-HO-, and 16-HO-CL were detected in plants, but their expected corresponding metabolites, HO-CLAs, were absent in max1 mutants. These results suggest that HO-CL derivatives may be predominant SLs in Arabidopsis, produced through MAX1 and LBO.

    DOI： 10.1002/pld3.219

    PubMed

  • Identification of two oxygenase genes involved in the respective biosynthetic pathways of canonical and non-canonical strigolactones in Lotus japonicus Reviewed

    Natumi Mori, Takahito Nomura, Kohki Akiyama

    Planta   251   40   2020.01

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1007/s00425-019-03332-x

  • Stimulation of asymbiotic sporulation in arbuscular mycorrhizal fungi by fatty acids Reviewed

    Hiromu Kameoka, Ippo Tsutsui, Katsuharu Saito, Yusuke Kikuchi, Yoshihiro Handa, Tatsuhiro Ezawa, Hideo Hayashi, Masayoshi Kawaguchi, Kohki Akiyama

    Nature Microbiology   4 ( 10 )   1654 - 1660   2019.10（ eISSN:2058-5276 ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    © 2019, The Author(s), under exclusive licence to Springer Nature Limited. Arbuscular mycorrhizal (AM) fungi are obligate symbionts that depend on living host plants to complete their life cycle1,2. This feature, which leads to their unculturability in the absence of plants, strongly hinders basic research and agricultural application of AM fungi. However, at least one AM fungus can grow and develop fertile spores independently of a host plant in co-culture with the bacterium Paenibacillus validus3. The bacteria-derived substances are thought to act as stimulants or nutrients for fungal sporulation, but these molecules have not been identified. Here, we show that (S)-12-methyltetradecanoic acid4,5, a methyl branched-chain fatty acid isolated from bacterial cultures, stimulates the branching of hyphae germinated from mother spores and the formation of secondary spores in axenic culture of the AM fungus Rhizophagus irregularis. Extensive testing of fatty acids revealed that palmitoleic acid induces more secondary spores than the bacterial fatty acid in R. irregularis. These induced spores have the ability to infect host plant roots and to generate daughter spores. Our work shows that, in addition to a major source of organic carbon6–9, fatty acids act as stimulants to induce infection-competent secondary spores in the asymbiotic stage and could provide the key to developing the axenic production of AM inoculum.

    DOI： 10.1038/s41564-019-0485-7

    PubMed

  • Regulation of biosynthesis, perception, and functions of strigolactones for promoting arbuscular mycorrhizal symbiosis and managing root parasitic weeds Reviewed

    Koichi Yoneyama, Xiaonan Xie, Kaori Yoneyama, Takahito Nomura, Ikuo Takahashi, Tadao Asami, Narumi Mori, Kohki Akiyama, Miyuki Kusajima, Hideo Nakashita

    Pest Management Science   75 ( 9 )   2353 - 2359   2019.09（ ISSN:1526-498X ） （ eISSN:1526-4998 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    © 2019 Society of Chemical Industry Strigolactones (SLs) are carotenoid-derived plant secondary metabolites that play important roles in various aspects of plant growth and development as plant hormones, and in rhizosphere communications with symbiotic microbes and also root parasitic weeds. Therefore, sophisticated regulation of the biosynthesis, perception and functions of SLs is expected to promote symbiosis of beneficial microbes including arbuscular mycorrhizal (AM) fungi and also to retard parasitism by devastating root parasitic weeds. We have developed SL mimics with different skeletons, SL biosynthesis inhibitors acting at different biosynthetic steps, SL perception inhibitors that covalently bind to the SL receptor D14, and SL function inhibitors that bind to the serine residue at the catalytic site. In greenhouse pot tests, TIS108, an azole-type SL biosynthesis inhibitor effectively reduced numbers of attached root parasites Orobanche minor and Striga hermonthica without affecting their host plants; tomato and rice, respectively. AM colonization resulted in weak but distinctly enhanced plant resistance to pathogens. SL mimics can be used to promote AM symbiosis and to reduce the application rate of systemic-acquired resistance inducers which are generally phytotoxic to horticultural crops. © 2019 Society of Chemical Industry.

    DOI： 10.1002/ps.5401

    PubMed

  • Strigolactone perception and deactivation by a hydrolase receptor DWARF14 Reviewed

    Yoshiya Seto, Rei Yasui, Hiromu Kameoka, Muluneh Tamiru, Mengmeng Cao, Ryohei Terauchi, Akane Sakurada, Rena Hirano, Takaya Kisugi, Atsushi Hanada, Mikihisa Umehara, Eunjoo Seo, Kohki Akiyama, Jason Burke, Noriko Takeda-Kamiya, Weiqiang Li, Yoshinori Hirano, Toshio Hakoshima, Kiyoshi Mashiguchi, Joseph P Noel, Junko Kyozuka, Shinjiro Yamaguchi

    Nature Communications   10 ( 1 )   191   2019.01

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1038/s41467-018-08124-7

  • Lotuslactone, a non-canonical strigolactone from Lotus japonicus Reviewed

    Xiaonan Xie, Narumi Mori, Kaori Yoneyama, Takahito Nomura, Kenichi Uchida, Koichi Yoneyama, Kohki Akiyama

    Phytochemistry   157   200 - 205   2019.01（ ISSN:0031-9422 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    © 2018 Elsevier Ltd Root exudates from Lotus japonicus were found to contain at least three different hyphal branching-inducing compounds for the arbuscular mycorrhizal (AM) fungus Gigaspora margarita, one of which had been previously identified as (+)-5-deoxystrigol (5DS), a canonical strigolactone (SL). One of the two remaining unknown hyphal branching inducers was purified and named lotuslactone. Its structure was determined as methyl (E)-2-(3-acetoxy-2-hydroxy-7-methyl-1-oxo-1,2,3,4,5,6-hexahydroazulen-2-yl)-3-(((R)-4-methyl-5-oxo-2,5-dihydrofuran-2-yl)oxy)acrylate, by 1D and 2D NMR spectroscopy, and HR-ESI- and EI-MS. Although lotuslactone, a non-canonical SL, contains the AB-ring and the enol ether-bridged D-ring, it lacks the C-ring and has a seven-membered cycloheptadiene in the A-ring part as in medicaol, a major SL of Medicago truncatula. Lotuslactone was much less active than 5DS, but showed comparable activity to methyl carlactonoate (MeCLA) in inducing hyphal branching of G. margarita. Other natural non-canonical SLs including avenaol, heliolactone, and zealactone (methyl zealactonoate) were also found to be moderate to weak inducers of hyphal branching in the AM fungus. Lotuslactone strongly elicited seed germination in Phelipanche ramosa and Orobanche minor, but Striga hermonthica seeds were 100-fold less sensitive to this stimulant.

    DOI： 10.1016/j.phytochem.2018.10.034

    PubMed

  • A femtomolar-range suicide germination stimulant for the parasitic plant Striga hermonthica Reviewed

    Daisuke Uraguchi, Keiko Kuwata, Yuh Hijikata, Rie Yamaguchi, Hanae Imaizumi, AM Sathiyanarayanan, Christin Rakers, Narumi Mori, Kohki Akiyama, Stephan Irle, Peter McCourt, Toshinori Kinoshita, Takashi Ooi, Yuichiro Tsuchiya

    Science   362 ( 6420 )   1301 - 1305   2018.12

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1126/science.aau5445

  • Anti-plant viral activity of peptaibols, trichorzins HA II, HA V, and HA VI, isolated from Trichoderma harzianum HK-61 Reviewed

    Kenji Kai, Keiji Mine, Kohki Akiyama, Satoshi Ohki, Hideo Hayashi

    Journal of Pesticide Science   43 ( 4 )   283 - 286   2018.11

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1584/jpestics.D18-039

  • 3-Hydroxycarlactone, a Novel Product of the Strigolactone Biosynthesis Core Pathway Reviewed International coauthorship

    Lina Baz, Narumi Mori, Jianing Mi, Muhammad Jamil, Boubacar A Kountche, Xiujie Guo, Aparna Balakrishna, Kun-Peng Jia, Martina Vermathen, Kohki Akiyama, Salim Al-Babili

    Molecular Plant   11 ( 10 )   1312 - 1314   2018.10

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1016/j.molp.2018.06.008

  • Low infection of Phelipanche aegyptiaca in Micro-Tom mutants deficient in CAROTENOID CLEAVAGE DIOXYGENASE 8 Reviewed

    Shoko Hasegawa, Takuya Tsutsumi, Shunsuke Fukushima, Yoshihiro Okabe, Junna Saito, Mina Katayama, Masato Shindo, Yusuke Yamada, Koichiro Shimomura, Kaori Yoneyama, Kohki Akiyama, Koh Aoki, Tohru Ariizumi, Hiroshi Ezura, Shinjiro Yamaguchi, Mikihisa Umehara

    International journal of molecular sciences   19 ( 9 )   2645   2018.09

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.3390/ijms19092645

  • Conversion of carlactone to carlactonoic acid is a conserved function of MAX1 homologs in strigolactone biosynthesis Reviewed

    Kaori Yoneyama, Narumi Mori, Tomoyasu Sato, Akiyoshi Yoda, Xiaonan Xie, Masanori Okamoto, Masashi Iwanaga, Toshiyuki Ohnishi, Hisashi Nishiwaki, Tadao Asami, Takao Yokota, Kohki Akiyama, Koichi Yoneyama, Takahito Nomura

    New Phytologist   218 ( 4 )   1522 - 1533   2018.06

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1111/nph.15055

  • Which are major players, canonical or non-canonical strigolactones? Reviewed International coauthorship

    Koichi Yoneyama, Xiaonan Xie, Kaori Yoneyama, Takaya Kisugi, Takahito Nomura, Yoshifumi Nakatani, Kohki Akiyama, Christopher SP McErlean

    Journal of Experimental Botany   69 ( 9 )   2231 - 2239   2018.04

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1093/jxb/ery090

  • Methyl zealactonoate, a novel germination stimulant for root parasitic weeds produced by maize Reviewed International coauthorship

    Xie X, Kisugi K, Yoneyama K, Nomura T, Akiyama K, Uchida L, Yokota T, McErlean CSP, Yoneyama K

    Journal of Pesticide Science   42 ( 2 )   58 - 61   2017.05

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1584/jpestics.D16-103

  • Carlactone-type strigolactones and their synthetic analogues as inducers of hyphal branching in arbuscular mycorrhizal fungi Reviewed

    Mori N, Nishiuma K, Sugiyama T, Hayashi H, Akiyama K

    Phytochemistry   130   90 - 98   2016.10

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.phytochem.2016.05.012

  • LATERAL BRANCHING OXIDOREDUCTASE acts in the final stages of strigolactone biosynthesis in Arabidopsis Reviewed

    Brewer PB, Yoneyama K, Filardo F, Meyers E, Scaffidi A, Frickey T, Akiyama K, Seto Y, Dun EA, Cremer JE, Kerr SC, Waters MT, Flematti GR, Mason MG, Weiller G, Yamaguchi S, Nomura T, Smith SM, Yoneyama K, Beveridge CA

    Proc Natl Acad Sci USA   113 ( 22 )   6301 - 6306   2016.05

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    Kind of work：Joint Work   International / domestic magazine：International journal  

  • Medicaol, a strigolactone identified as a putative didehydro-orobanchol isomer, from Medicago truncatula Reviewed

    Tokunaga T, Hayashi H, Akiyama K*.

    Phytochemistry   111 ( 3 )   91 - 97   2015.02

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Carlactone is converted to carlactonoic acid by MAX1 in Arabidopsis and its methyl ester can directly interact with AtD14 in vitro Reviewed

    Abe S, Sado A, Tanaka R, Kisugi T, Asami K, Ota S, Kim HI, Yoneyama K, Xie X, Ohnishi T, Seto Y, Yamaguchi S*, Akiyama K*, Yoneyama K, Nomura T*.

    Proc Natl Acad Sci USA   111 ( 50 )   18084 - 18089   2014.12

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Carlactone is an endogenous biosynthetic precursor for strigolactones Reviewed

    Seto Y, Sado A, Asami K, Hanada A, Umehara M, Akiyama K, Yamaguchi S

    Proc Natl Acad Sci USA   111 ( 4 )   1640 - 1645   2014.01

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Lupin pyranoisoflavones inhibiting hyphal development in arbuscular mycorrhizal fungi Reviewed

    Akiyama, K., Tanigawa, F, Kashihara, T., and Hayashi, H.

    Phytochemistry   71   1865 - 1871   2010.11

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Structural requirements of strigolactones for hyphal branching in AM fungi Reviewed

    Akiyama, K., Ogasawara, S., Ito, S., and Hayashi, H.

    Plant and Cell Physiology   51   1104 - 1117   2010.07

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Inhibition of shoot branching by new terpenoid plant hormones Reviewed

    Umehara, M., Hanada, A., Yoshida, S., Akiyama, K., Arite, T., Kamiya-Takeda, N., Magome, H., Kamiya, Y., Shirasu, K., Yoneyama, K., Kyozuka, J., and Yamaguchi, S.

    Nature   455   195 - 200   2008.09

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Chemical Identification and Functional Analysis of Apocarotenoids Involved in the Development of Arbuscular Mycorrhizal Symbiosis Reviewed

    K. Akiyama

    Bioscience Biotechnology and Biochemistry   71 ( 6 )   1405 - 1414   2007.06

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Single Work   International / domestic magazine：International journal  

    DOI： 10.1271/bbb.70023

  • Strigolactones: Chemical Signals for Fungal Symbionts and Parasitic weeds in Plant Roots Reviewed

    K. Akiyama, H. Hayashi

    Annals of Botany   97   925 - 931   2006.06

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    Authorship：Lead author,　Corresponding author   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi Reviewed

    K. Akiyama, H. Matsuzaki, K. Hayashi, H

    Nature   435   824 - 827   2005.06

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Arbuscular Mycorrhizal Fungus- promoted Accumulation of Two New Triterpenoids in Cucumber Roots Reviewed

    Akiyama. K, and Hayashi. H.

    Bioscience Biotechnology and Biochemistry   66 ( 4 )   762 - 769   2002.04

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1271/bbb.66.762

  • Isolation and identification of a phosphate deficiency-induced C-glycosylflavonoid that stimulates arbuscular mycorrhiza formation in melon roots Reviewed

    Akiyama. K, Matsuoka. H, and Hayashi. H.

    Molecular Plant-Microbe Interactions   15 ( 4 )   334 - 340   2002.04

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1094/MPMI.2002.15.4.334

  • A novel method for chemo-enzymatic synthesis of elicitor-active chitosan oligomers and partially N-deacetylated chitin oligomers using N-acylated chitotrioses as substrates in a lysozyme-catalyzed transglycosylation system Reviewed

    K. Akiyama, K. Kawazu, A. Kobayashi

    Carbohydrate Research   279   151 - 160   1995.12

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

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Books and Other Publications

  • もっと菌根の世界　知られざる根圏のパートナーシップ

    齋藤雅典、奈良一秀、木下晃彦、小林久泰、馬場隆士、広瀬大、末次健司、秋山康紀、斎藤勝晴、小八重善裕、久我ゆかり、成澤才彦（ Role： Contributor ,  第５章　菌根共生の鍵となる物質を探してーストリゴラクトンの発見とその後の展開）

    築地書館  2023.09  （ ISBN:978-4806716556 ）

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    Book type：General book, introductory book for general audience

  • アーバスキュラー菌根菌の共生におけるシグナル物質としてのストリゴラクトンの発見と機能. 植物のシグナル伝達：分子と応答

    秋山　康紀，林　英雄（ Role： Joint author）

    共立出版  2010.05 

  • 発芽生物学 種子発芽の生理・生態・分子機構

    秋山康紀，林英雄（ Role： Joint author）

    文一総合出版  2009.03 

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    Responsible for pages：5  

MISC

Grant-in-Aid for Scientific Research

  • Dual function of strigolactones as plant hormones to control growth and as signaling molecules to induce symbiosis: its origin and evolution

    Grant-in-Aid for Specially Promoted Research  2024

  • 菌根共生におけるブテノライドシグナルの分子基盤の解明とその応用

    Grant-in-Aid for Scientific Research(A)  2024

Charge of on-campus class subject

  • 農学概論

    2024   Weekly class   Undergraduate

  • 生命機能化学概論

    2024   Weekly class   Undergraduate

  • 生命機能化学特論A

    2024   Weekly class   Graduate school

  • 農学概論

    2022   Weekly class   Undergraduate

  • 生命機能化学特殊講義B

    2022   Intensive lecture   Undergraduate

  • 生命機能化学概論

    2022   Weekly class   Undergraduate

  • 生命機能化学特論A

    2022   Weekly class   Graduate school

  • 応用生命科学特別研究実験AII

    2022   Intensive lecture   Graduate school

  • 応用生命科学特別研究実験BII

    2022   Intensive lecture   Graduate school

  • 応用生命科学特別研究実験CII

    2022   Intensive lecture   Graduate school

  • 生理活性物質化学特論

    2022   Weekly class   Graduate school

  • 生命機能化学研究プレゼンテーション

    2022   Intensive lecture   Graduate school

  • 生命機能化学キャリアデザイン

    2022   Intensive lecture   Graduate school

  • 有機化学II【応用生命科学類】

    2022   Weekly class   Undergraduate

  • 天然物化学

    2022   Weekly class   Undergraduate

  • Research Project in Advanced Applied Life Sciences CII

    2021   Practical Training  

  • Research Project in Advanced Applied Life Sciences CI

    2021   Practical Training  

  • Research Project in Advanced Applied Life Sciences BII

    2021   Practical Training  

  • Research Project in Advanced Applied Life Sciences BI

    2021   Practical Training  

  • Research Project in Advanced Applied Life Sciences AII

    2021   Practical Training  

  • Research Project in Advanced Applied Life Sciences AI

    2021   Practical Training  

  • Research Project in Applied Life Sciences B

    2021   Practical Training  

  • Research Project in Applied Life Sciences A

    2021   Practical Training  

  • Career Design in the Field of Applied Life Sciences

    2021    

  • Topics in Applied Biological Chemistry B

    2021    

  • Organic Chemistry II

    2021    

  • First Year Seminar

    2021    

  • Introduction to Life, Environment, and Advanced Sciences

    2021    

  • Natural Products Chemistry

    2021    

  • General Principles of Applied Biological Chemistry

    2021    

  • Topics in Bioactive Natural Products

    2021    

  • Reviews for Applied Life Sciences

    2021    

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Visiting Lectures　⇒ Link to the list of Visiting Lectures

  • アーバスキュラー菌根共生―4億年続いてきた共生系―

    Category：Agricultural science (applied biology, biofunctional chemistry, green space environmental science)

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    Audience：Junior high school students,　High school students,　College students,　Teachers,　Researchers,　General

    Keyword：菌根菌/共生/ストリゴラクトン 

    植物と菌類との共生体である菌根の成り立ち、植物生産や生態系での働きについて解説

Academic Activities

  • 植物化学調節学会社員（代議員）

    Role(s)： Planning, management, etc.

    植物化学調節学会  2020.10 - 2024.09

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    Type：Academic society, research group, etc. 

  • 日本農芸化学会関西支部参与

    Role(s)： Planning, management, etc.

    2006.04 - Now

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    Type：Academic society, research group, etc. 

  • 植物化学調節学会編集委員

    Role(s)： Planning, management, etc.

Job title

  • Job title within the department

    School of Agriculture Department of Applied Biological Chemistry 

    学科長  2022.04 - 2024.03