Updated on 2024/04/04

写真a

 
Nishimura Kazuhiko
 
Organization
Graduate School of Veterinary Science Department of Veterinary Science Associate Professor
School of Veterinary Science Department of Veterinary Science
Title
Associate Professor
Affiliation
Institute of Veterinary Science
Contact information
メールアドレス

Position

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - Now

  • School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - Now

Degree

  • 博士(農学） （ Others ）

Research Areas

  • Life Science / Veterinary medical science

  • Life Science / Veterinary medical science

  • Life Science / Veterinary medical science

Research Interests

  • 獣医衛生学

  • 毒性学

  • Veterinory hygiene

  • Toxicology

Research subject summary

  • 造血促進機構に関する研究

  • トリパノソーマ原虫に関する研究

  • 乳牛の健康状態変化予測に関する研究

  • Analysis of effects of chronic exposure to low-concentration metals

Research Career

  • 乳牛の健康状態変化予測に関する研究

    糞便中成分、健康状態評価、飼養管理、腸内細菌 

  • 造血促進機構に関する研究

    貧血、造血、エリスロポエチン 

  • トリパノソーマ原虫に関する研究

    トリパノソーマ、人獣共通感染症、寄生虫症、免疫応答 

Professional Memberships

  • 獣医疫学会

  • 日本養豚学会

  • 日本細菌学会

  • 日本畜産学会

  • 日本獣医学会

  • ヒトと動物の関係学会

  • American Society of Parasitologists

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Papers

  • Effect of long-term treatment with trivalent chromium on erythropoietin production in HepG2 cells Reviewed

    Nishimura Kazuhiko,Suzuka Iitaka , Takuya Sakaki, Keigo Tsuji, Akari Yoshimoto, Md Anamul Haque , Hiroshi Nakagawa

    752   109872   2024.02（ ISSN:00039861 ）

    　More details

    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

    DOI： 10.1016/j.abb.2023.109872

    PubMed

  • Effect of pentavalent inorganic arsenic salt on erythropoietin production and autophagy induction

    Nishimura Kazuhiko, Naotake Kiriyama, Kazuya Ogawa, Reo Inoue, Md Anamul Haque, Hiroshi Nakagawa

    734   109487   2023.01（ ISSN:00039861 ）

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    Authorship：Lead author,　Corresponding author  

    DOI： 10.1016/j.abb.2022.109487

    PubMed

  • Effect of trivalent chromium on erythropoietin production and the prevention of insulin resistance in HepG2 cells

    Kazuhiko Nishimura, Suzuka Iitaka, Hiroshi Nakagawa

    Archives of Biochemistry and Biophysics   708   108960 - 108960   2021.09（ ISSN:0003-9861 ）

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.abb.2021.108960

  • Carbon tetrachloride suppresses ER-Golgi transport by inhibiting COPII vesicle formation on the ER membrane in the RLC-16 hepatocyte cell line Reviewed

    Hiroshi Nakagawa, Masayuki Komori, Kazuhiko Nishimura

    45 ( 3 )   2021.01

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    Publishing type：Research paper (scientific journal)   Kind of work：Joint Work   International / domestic magazine：International journal  

  • Effects of sorbitol and lactate on erythropoietin production in HepG2 cells.

    Kazuhiko Nishimura, Hideaki Katsuyama, Masahiro Ohishi, Arisa Hirabayashi, Kensyo Matsuda, Hiroshi Nakagawa

    Biochemical and biophysical research communications   523 ( 1 )   54 - 59   2020.02

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Promotion of erythropoietin (EPO) production is important for erythropoiesis as well as cell viability. The most effective inducing factor for EPO production is hypoxia. Hypoxia inducible factor (HIF), a regulator of EPO production, is increased under hypoxic conditions and is also affected by various regulators such as sirtuin1 (SIRT1). SIRT1 is regulated by the cytoplasmic redox state, which is thought to affect EPO production. Therefore, we investigated the effects of sorbitol and lactic acid, which serve as substrates for cellular respiration and bring cells into a reduced state, on EPO production in HepG2 cells. The addition of low-concentration sorbitol to HepG2 cells produced a mildly reduced state similar to that of hypoxia and increased NAD+, SIRT1, and HIF-α, and EPO mRNA expression. On the other hand, lactate suppressed EPO mRNA expression at all concentrations. Inhibition of lactate production from pyruvate abolished the effect of low sorbitol concentrations on EPO mRNA expression. When low-concentration sorbitol and a reducing agent were administered simultaneously, the effect of increasing EPO mRNA expression disappeared. It was suggested that SIRT1 and EPO production increased under conditions where lactate production was not suppressed, even under mildly reduced conditions similar to hypoxia.

    DOI： 10.1016/j.bbrc.2019.12.001

    PubMed

  • Effects of sorbitol and lactate on erythropoietin production in HepG2 cells Reviewed

    K. Nishimura, H. Katsuyama, M. Ohishi, A. Hirabayashi, K. Matsuda, H. Nakagawa.

    Biochemical and Biophysical Research Communications 雑誌   523 ( 1 )   2020.02

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    Kind of work：Joint Work  

  • Effect of erythropoietin production induced by hypoxia on autophagy in HepG2 cells. Reviewed

    Nishimura K, Goto K, Nakagawa H.

    Biochem Biophys Res Commun. 雑誌   495 ( 1 )   2018.01

  • Effect of quercetin on cell protection via erythropoietin and cell injury of HepG2 cells. Reviewed

    Nishimura K, Matsumoto R, Yonezawa Y, Nakagawa H.

    Arch Biochem Biophys 雑誌   636   2017.12

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    Kind of work：Joint Work  

  • Inhibition of PLD1 activity causes ER stress via regulation of COPII vesicle formation Reviewed

    Hiroshi Nakagawa, Kazuki Hazama, Katsumasa Ishida, Masayuki Komori, Kazuhiko Nishimura, Saburou Matsuo

    Biochemical and Biophysical Research Communications 雑誌   2017.06

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    Kind of work：Joint Work  

  • An ATF4-Signal-Modulating Machine Other Than GADD34 Acts in ATF4-to-CHOP Signaling to Block CHOP Expression in ER-Stress-Related Autophagy. Reviewed

    N. Iwasaki, Y. Sugiyama, S. Miyazaki, H. Nakagawa, K. Nishimura, S. Matsuo

    Journal of Cellular Biology 雑誌   116 ( 7 )   1300 - 1309   2015.07

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    Kind of work：Joint Work  

  • The effect of iron on erythropoietin production in HepG2 cells via oxidative stress. Reviewed

    K. Nishimura, M. Tokida,H. Katsuyama, H. Nakagawa, S. Matsuo.

    Cell Biology International   38   1321 - 1329   2014.05

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    Kind of work：Joint Work  

  • Selection of autophagy or apoptosis in cells exposed to ER-stress depends on ATF4 expression pattern with or without CHOP expression. Reviewed

    H. Matsumoto, S. Miyazaki, S. Matsuyama, M. Takeda, M. Kawano, H. Nakagawa, K. Nishimura, S. Matsuo.

    Biology Open   Vol.2   1084 - 90   2013.08

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    Kind of work：Joint Work  

  • Molecular characterization of cytolethal distending toxin gene-positive Escherichia coli from healthy cattle and swine in Nara, Japan Reviewed

    A. Hinenoya, K. Shima, M. Asakura, K. Nishimura, T. Tsukamoto, T. Ooka, T. Hayashi, T. Ramamurthy, S. Faruque, S. Yamasaki.

    BMC Microbiology   2013.08

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    Kind of work：Joint Work  

  • Sar1 translocation onto the ER-membrane for vesicle budding has different pathways for promotion and suppression of ER-to-Golgi transport mediated through H89-sensitive kinase and ER-resident G protein. Reviewed

    Nakagawa H, Ishizaki M, Miyazaki S, Abe T, Nishimura K, Komori M, Matsuo S

    Mol Cell Biochem.   Vol.366   175 - 82   2012.04

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    Kind of work：Joint Work  

  • ER-resident Gi2 protein controls sar1 translocation onto the ER during budding of transport vesicles. Reviewed

    Nakagawa H, Umadome H, Miyazaki S, Tanaka K, Nishimura K, Komori M, Matsuo S.

    J Cell Biochem   Vol.112   2250 - 6   2011.09

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    Kind of work：Joint Work  

  • Differential effects of trypanosoma brucei gambiense and trypanosoma brucei brucei on rat macrophages. Reviewed

    K. Nishimura, H. Nakaya, H. Nakagawa, S. Matsuo, Y. Ohnishi, S. Yamasaki.

    J. Parasitol.   2011

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    Kind of work：Joint Work  

  • Effect of trypanosoma brucei brucei on erythropoiesis in infected rats Reviewed

    K. Nishimura, H. Nakaya, H. Nakagawa, S. Matsuo, Y. Ohnishi, S. Yamasaki.

    J. Parasitol.   2011

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    Kind of work：Joint Work  

  • Effect of Polyamine-Deficient Chow on Trypanosoma Brucei Brucei Infection in Rats. Reviewed

    K. Nishimura, T. Yanase, H. Nakagawa, S. Matsuo, Y. Ohnishi and S. Yamasaki

    J. Parasitol.   Vol.95   781 - 786   2009.08

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    Kind of work：Joint Work  

  • Cytokines and Nitric Oxide Production by Trypanosoma Brucei Infection in Polyamine-Deficient Chow Feeding Rats. Reviewed

    K. Nishimura, M. Yagi, Y. Ohnishi, and S. Yamasaki.

    J. Parasitol.   Vol.94   107 - 113   2008.06

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    Kind of work：Joint Work  

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Books and Other Publications

  • 薬理学・毒性学実験

    日本獣医薬理学・毒性学会, 大濱 剛, 堀 正敏, 室井 喜景, 石塚 真由美 , 宇野 泰広, 西村 和彦

    文永堂出版  2023  （ ISBN:9784830032868 ）

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  • 獣医毒性学第2版

    日本比較薬理学・毒性学会編（ Role： Joint author）

    近代出版  2020.03 

Presentations

▼display all

Industrial Property Rights

  • 糞便中成分による哺乳動物の健康状態把握方法

    西村和彦

    　More details

    property_type：Patent 

  • 動物の汚染調査方法

    西村和彦、石井利明

    　More details

    property_type：Patent 

    Patent/Registration no：5589185 

Grant-in-Aid for Scientific Research

  • クロムによるインシュリン抵抗性抑制とエリスロポエチンの関係

    Grant-in-Aid for Scientific Research(C)  2023

  • クロムによるインシュリン抵抗性抑制とエリスロポエチンの関係

    Grant-in-Aid for Scientific Research(C)  2022

  • クロムによるインシュリン抵抗性抑制とエリスロポエチンの関係

    2021

Outline of education staff

  • 毒性学および毒性学に基づく食品、環境衛生に関する教育を担当している。

Charge of on-campus class subject

  • 獣医科学特別研究1

    2023   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2023   Intensive lecture   Graduate school

  • 獣医科学特別演習1

    2023   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2023   Intensive lecture   Graduate school

  • 獣医環境制御管理学

    2023   Intensive lecture   Undergraduate

  • 毒性学実習

    2023   Weekly class   Undergraduate

  • 毒性学B

    2023   Weekly class   Undergraduate

  • 毒性学基礎実習

    2023   Intensive lecture   Undergraduate

  • 小動物基礎臨床実習

    2023   Intensive lecture   Undergraduate

  • 獣医環境科学

    2023   Weekly class   Undergraduate

  • 小動物基礎臨床実習

    2023   Intensive lecture   Undergraduate

  • 生体環境制御学特別講義A

    2023   Intensive lecture   Graduate school

  • 毒性学基礎実習

    2023   Intensive lecture   Undergraduate

  • 臨床基礎実習

    2023   Weekly class   Undergraduate

  • 獣医環境科学実習

    2023   Intensive lecture   Undergraduate

  • 食品循環科学

    2023   Weekly class   Undergraduate

  • 獣医環境科学

    2023   Weekly class   Undergraduate

  • 生物統計学演習

    2023   Weekly class   Undergraduate

  • 毒性学A

    2023   Weekly class   Undergraduate

  • 国際・国内インターンシップ

    2023   Intensive lecture   Graduate school

  • 統計学

    2023   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2023   Intensive lecture   Graduate school

  • 獣医科学特別演習1

    2023   Intensive lecture   Graduate school

  • 獣医科学演習

    2023   Intensive lecture   Graduate school

  • 毒性学B

    2023   Weekly class   Undergraduate

  • 毒性病理学実習

    2023   Intensive lecture   Undergraduate

  • 獣医環境制御管理学

    2023   Intensive lecture   Undergraduate

  • 毒性学実習

    2023   Weekly class   Undergraduate

  • 生物学実験

    2023   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2023   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2023   Intensive lecture   Graduate school

  • 獣医科学特別演習1

    2023   Intensive lecture   Graduate school

  • 獣医科学ミニレビュー

    2023   Intensive lecture   Graduate school

  • 獣医科学演習

    2023   Intensive lecture   Graduate school

  • 食品科学特論

    2023   Intensive lecture   Graduate school

  • 国際・国内インターンシップ

    2023   Intensive lecture   Graduate school

  • 毒性学

    2023   Weekly class   Undergraduate

  • 獣医体験演習

    2023   Weekly class   Undergraduate

  • 基礎動物生理学

    2023   Weekly class   Undergraduate

  • 生体環境制御学特別講義A

    2022   Intensive lecture   Graduate school

  • 毒性学基礎実習

    2022   Intensive lecture   Undergraduate

  • 獣医環境科学実習

    2022   Intensive lecture   Undergraduate

  • 食品循環科学

    2022   Weekly class   Undergraduate

  • 獣医環境科学

    2022   Weekly class   Undergraduate

  • 生物統計学演習

    2022   Weekly class   Undergraduate

  • 毒性学A

    2022   Weekly class   Undergraduate

  • 初年次ゼミナール

    2022   Weekly class   Undergraduate

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 獣医科学特別演習1

    2022   Intensive lecture   Graduate school

  • 国際・国内インターンシップ

    2022   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 毒性学B

    2022   Weekly class   Undergraduate

  • 毒性学実習

    2022   Weekly class   Undergraduate

  • 獣医環境制御管理学

    2022   Intensive lecture   Undergraduate

  • 毒性病理学実習

    2022   Intensive lecture   Undergraduate

  • 基礎動物生理学

    2022   Weekly class   Undergraduate

  • 臨床基礎実習

    2022   Weekly class   Undergraduate

  • 獣医体験演習

    2022   Weekly class   Undergraduate

  • 生物学実験獣医

    2022   Intensive lecture   Graduate school

  • Special Lecture: Bioenvironmental Sciences A

    2021    

  • Practice in Basic Toxicology

    2021   Practical Training  

  • Practice in Veterinary Environmental Science

    2021   Practical Training  

  • Practice in Toxicologic Pathology

    2021   Practical Training  

  • Environmental Hazard Control and Regulation

    2021    

  • Practice in Toxicology

    2021   Practical Training  

  • Fundamental Experiments of Biology

    2021   Practical Training  

  • Animal Physiology on Basic

    2021    

  • Introduction to Life, Environment, and Advanced Sciences

    2021    

  • Veterinary Environmental Science

    2021    

  • Basic clinical practices

    2021   Practical Training  

  • Global Circulation of Food and Hazards in Environments

    2021    

  • Practice in Biological Statistics

    2021    

  • Toxicology B

    2021    

  • Toxicology A

    2021    

▼display all

Charge of off-campus class subject

  • 食品衛生

    2018.04
    -
    Now

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    Level：Undergraduate (specialized)  Country：Japan

Faculty development activities

  • 2020

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    獣医毒性学第2版 池田正浩，池中良徳、西村和彦、中川博史他

Number of papers published by graduate students

  • 2023

    Number of undergraduate student / college student presentations：4  Number of graduate students presentations：1

  • 2022

    Number of undergraduate student / college student presentations：4  Number of graduate students presentations：1

  • 2021

    Number of undergraduate student / college student presentations：1