Researcher Profiles - Kawate Noritoshi

写真a

Kawate Noritoshi

Organization

Graduate School of Veterinary Science Department of Veterinary Science Professor
School of Veterinary Science Department of Veterinary Science

Affiliation

Institute of Veterinary Science

Contact information

Homepage

https://www.omu.ac.jp/vet/therio/

Affiliation campus

Rinku Campus

Position

Graduate School of Veterinary Science Department of Veterinary Science

Professor 2022.04 - Now
School of Veterinary Science Department of Veterinary Science

Professor 2022.04 - Now

Degree

博士（農学）（ Others ）

Research Areas

Life Science / Veterinary medical science
Life Science / Animal production science / 応用動物科学
Life Science / Veterinary medical science / 基礎獣医学
Life Science / Veterinary medical science / 応用獣医学
Life Science / Veterinary medical science / 臨床獣医学

Research Interests

Reproductive endocrinology
Theriogenology

Research subject summary

Secretory changes of INSL3 in circulation of female cattle and expression and roles of its receptor in germ cells
黒毛和種子の雌雄子ウシの発育・栄養状態と生殖機能発達との関連性解析

Research Career

Studies on basic and clinical application on reproductive endocrinology in domestic animals

International Joint Research

1998.04 - Now

Professional Memberships

日本獣医師会

1991.04 - Now
日本獣医学会

1987.04 - Now
日本繁殖生物学会（旧家畜繁殖学会）

1987.04 - Now

Committee Memberships (off-campus)

令和4年度臨床実習等支援事業における育成・確保支援検討会委員家畜衛生対策推進協議会

2022.06 - 2023.03
令和3年度家畜診療技術者研究発表会審査委員兵庫県農業共済組合

2022.02
特別研究員等審査会委員独立行政法人　日本学術振興会

2021.04 - 2022.03
令和3年度臨床実習等支援事業における育成・確保支援検討会委員家畜衛生対策推進協議会

2021.04 - 2022.03
獣医師養成確保修学資金給付事業に係る委員公益社団法人　中央畜産会

2020.04 - 2024.03
神戸大学大学院農学研究科附属食資源教育研究センター共同利用推進委員会委員神戸大学

2020.04 - 2021.03
育成・確保支援検討会委員委嘱及び同検討会の書面開催家畜衛生対策推進協議会

2020.04 - 2021.03
審査委員和歌山県農業共済組合

2020.04 - 2021.03
特別研究員等審査会委員等独立行政法人日本学術振興会

2020.04 - 2021.03
学会長日本産業動物獣医学会近畿地区

2019.04 - 2024.03

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Awards

日本繁殖学会学術賞

川手憲俊

2003.09 日本繁殖生物学会学術賞反芻家畜の卵巣における黄体形成ホルモンレセプターの発現調節ならびに卵胞嚢腫の発生機構に関する研究

　More details

Country：Japan
Oral Presentation in Reproductive endocrinology 1

Weerakoon WWPN et al

2017.09 4th World Congress of Rerproductive Biology Comparison of plasma insulin-like growth factor-I, insulin-like peptide 3, testosterone and inhibin concentrations around puberty in Japanese Black beef bulls between normal and abnormal semen

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Country：Japan

Introduction
Studies have been very limited to clarify associations among metabolic status, testicular hormonal secretions and semen characteristics in bulls. The present study was designed to compare plasma insulin-like growth factor-I (IGF-I), insulin-like peptide 3 (INSL3), testosterone and inhibin concentrations around puberty in beef bulls between normal and abnormal semen.

Materials and Methods
Blood samples were obtained monthly from Japanese Black beef bulls (n = 66) from 4 to 24 months of age. Bulls were divided into groups based on their semen parameters; normal (N), abnormal fresh (A) and low fertility after freezing and thawing (L). Abnormal fresh semen was further divided into malformation only (M) and malformation plus low motility (M+L). Plasma IGF-I, INSL3, testosterone and inhibin concentrations were measured by either EIA or TRFIA.

Results and Discussion
Plasma IGF-I concentrations were lower (P < 0.05) in L group than N group at 8-9, 11, 15-21 months. Plasma INSL3 concentrations were lower (P < 0.001) in M+L group than N group at 6-22 months. Plasma testosterone concentrations did not differ among N, A and L groups. Plasma inhibin concentrations were lower (P < 0.05) in A and L groups than N group at 8-13, 16, 19-20 and 10-12, 16-21 months, respectively. These results suggest that lower plasma IGF-I concentrations in bulls may be associated with low fertility of frozen semen. Lower INSL3 concentrations are a likely cause for sperm malformation plus low motility while reduced inhibin secretion can be 　responsible for both of fresh semen abnormality and low fertility.
近畿地区奨励賞（共同研究者の木伏雅彦氏が発表した演題）

2019.09 日本獣医産業動物学会（近畿）
大阪府獣医師会長賞

2008.05 大阪府獣医師会
中村賞

2006.05 大阪府獣医師会
学長顕彰（指導の社会人大学院生；坂瀬充洋氏が発表した演題）

2006.03 大阪府立大学
近畿地区奨励賞（指導の社会人大学院生；坂瀬充洋氏が発表した演題）

2005.09 日本産業動物学会
近畿地区奨励賞（指導の社会人大学院生；坂瀬充洋氏が発表した演題）

2004.09 日本産業動物学会
学長顕彰

2004.06 大阪府立大学
近畿地区奨励賞

2003.09 日本産業動物学会

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Job Career (off-campus)

山口大学農学部　助手

1991.02 - 1998.03

Papers

Insulin-like peptide 3 in domestic animals with normal and abnormal reproductive functions, in comparison to rodents and humans Invited Reviewed

Kawate N. 21 ( 1 ) e12485 2022.10（ ISSN:14455781 ）

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Authorship：Lead author,　Corresponding author Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

DOI： 10.1002/rmb2.12485

PubMed

Other URL： https://onlinelibrary.wiley.com/doi/10.1002/rmb2.12485
Quantitative analyses of insulin-like peptide 3 and sex steroid hormones in dominant follicles and corpora lutea during the estrus cycle and in follicular cysts in beef heifers Reviewed International coauthorship

WIMALARATHNE Hewage Dilhan Anuradha, WAKO Hiroaki, KAWATE Noritoshi

Journal of Reproduction and Development 68 ( 5 ) 324 - 329 2022（ ISSN:09168818 ）（ eISSN:13484400 ）

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Authorship：Corresponding author Publishing type：Research paper (scientific journal) International / domestic magazine：International journal

<p> Insulin-like peptide 3 (INSL3) and sex steroids were measured in bovine dominant follicles and corpora lutea during the estrus cycle and in follicular cysts. Paired ovaries from beef heifers (n = 47) were classified, by their morphological features, either into four stages of the estrus cycle (Day 1 = day of ovulation, Day 20 = day of estrus) as Stage I (Days 1–4; n = 8), Stage II (Days 5–10; n = 10), Stage III (Days 11–17; n = 8), and Stage IV (Days 18–20; n = 11) or follicular cystic (n = 10). Cysts (n = 15) were subdivided into estrogen-active (n = 7) and estrogen-inactive (n = 8) cysts. INSL3, testosterone, and estradiol-17β concentrations in the dominant follicular fluid of Stage IV were higher than those in Stages II and III (P < 0.05). INSL3 concentrations in the cystic fluid were similar to those in dominant follicles at Stage IV, whereas testosterone and estradiol-17β concentrations were lower in cysts (P < 0.05). INSL3 content per estrogen-inactive cyst was higher than that of Stage IV (P < 0.05). INSL3 and progesterone concentrations in luteal tissue and contents per corpus luteum were higher in Stages II and III (P < 0.05). In conclusion, INSL3 secretion in bovine dominant follicles increased with maturation. Follicular cysts may retain the production of INSL3 during their formation but tend to lose the capacity for testosterone secretion. Estrogen-inactive cysts subjected to advanced atresia may accumulate more INSL3. INSL3 production in bovine corpora lutea is enhanced during maturation.</p>

DOI： 10.1262/jrd.2022-018

PubMed

Other URL： https://www.jstage.jst.go.jp/article/jrd/68/5/68_2022-018/_article/-char/en
Plasma estradiol-17β, cortisol, and insulin concentrations and serum biochemical parameters surrounding puberty in Japanese Black beef bulls with normal and abnormal semen.

Weerakoon WWPN, Sakase M, Kohama N, Kawate N.

Theriogenology 148 18 - 26 2020.05

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Authorship：Last author,　Corresponding author Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： 10.1016/j.theriogenology.2020.02.035
Inhibitory effects of long-term repeated treatments of a sustainable GnRH antagonist, degarelix acetate, on caprine testicular functions Reviewed

Kawate N, Kanuki R, Hannan MA, Weerakoon WWPN.

Journal of Reproduction and Development 66 587 - 592 2020.12

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Authorship：Lead author,　Corresponding author Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： https://doi.org/10.1262/jrd.2020-035

Other URL： https://www.jstage.jst.go.jp/article/jrd/66/6/66_2020-035/_article/-char/en
LH and testosterone secretions in response to GnRH challenge in pubertal Japanese Black beef bulls with normal and abnormal semen. Reviewed International coauthorship

Sakase M, Weerakoon WWPN, Hannan MA, Kohama N, Tamada H, Kawate N

J Vet Med Sci 80 1829 - 1833 2018.12

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Authorship：Corresponding author Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： 10.1292/jvms.18-0151

Other URL： https://www.jstage.jst.go.jp/article/jvms/80/12/80_18-0151/_article
Relationships of plasma insulin-like peptide 3, testosterone, inhibin, and insulin-like growth factor-I concentrations with scrotal circumference and testicular weight in Japanese Black beef bull calves Reviewed

Sakase M, Kitagawa K, Kibushi M, Kawate N, Weerakoon WWPN, Hannan MA, Kohama N, Tamada H

J Reprod Dev 64 401 - 407 2018.10

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Authorship：Corresponding author Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： 10.1262/jrd.2018-034

Other URL： https://www.jstage.jst.go.jp/article/jrd/64/5/64_2018-034/_article
Plasma IGF-I, INSL3, testosterone, inhibin concentrations and scrotal circumferences surrounding puberty in Japanese Black beef bulls with normal and abnormal semen Reviewed International coauthorship

Weerakoon WWPN, Sakase M, Kawate N, Hannan MA, Kohama N, Tamada H

Theriogenology 114 54 - 62 2018.07

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Authorship：Corresponding author Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： 10.1016/j.theriogenology.2018.03.006
Effects of gonadotropin-releasing hormone antagonist degarelix on musth and serum testosterone concentrations in Asian elephants (elephas maximus) Reviewed International coauthorship

Pathirana IN, Rajapaksa C, Kawate N, Wimalarathne A, Fonseka L, Weerakoon PN, Hannan MA, Alexander B, Pushpakumara A, Ariyaratne S, Tamada H

J Zoo Wildl Med 49 779 - 783 2018.09

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Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： 10.1638/2018-0019.1.
Serum concentrations and testicular expressions of insulin-like peptide 3 and Anti-Müllerian hormone in normal and cryptorchid male horses. Reviewed International coauthorship

Tsogtgerel M, Komyo N, Murase H, Hannan MA, Watanabe K, Ohtaki T, Tsumagari S, Kawate N, Nambo Y.

Theriogenology 154 135 - 142 2020.09

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Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal
Age related and seasonal changes of plasma concentrations of insulin-like peptide 3 and testosterone from birth to early-puberty in Thoroughbred male horses. Reviewed International coauthorship

Hannan MA, Murase H, Sato F, Tsogtgerel M, Kawate N, Nambo Y

Theriogenology 132 212 - 217 2019.02

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Publishing type：Research paper (scientific journal) Kind of work：Joint Work International / domestic magazine：International journal

DOI： 10.1016/j.theriogenology.2019.04.014
Efficacy of mechanical micro-vibration in the development of bovine embryos during in vitro maturation and culture. Reviewed

Takahashi M, Honda T, Hatoya S, Inaba T, Kawate N, Tamada H

J Vet Med Sci 雑誌 80 532 - 535 2018.03

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Kind of work：Joint Work
Treatment with the MAPK kinase inhibitor U0126 during the first two hours of in vitro maturation improves bovine oocyte developmental competence. Reviewed

Shinohara T, Ohta Y, Kawate N, Takahashi M, Sakagami N, Inaba T, Tamada H.

Reprod Domest Anim 雑誌 53 270 - 273 2018.02

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Kind of work：Joint Work

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Books and Other Publications

獣医繁殖学第4版 Reviewed

川手憲俊（ Role： Joint author , 第7章生殖工学 2.発情と排卵の同期化）

文栄堂 2012.02 （ ISBN:978-4-8300-3239-4 ）

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Total pages：567 Responsible for pages：230-236 Book type：Textbook, survey, introduction
獣医繁殖学マニュアル第2版

玉田尋通、川手憲俊、喜田加世子（ Role： Joint author , 第4章犬および猫 6.雌犬の繁殖障害, 7. 雄犬の繁殖障害, 8. 周産期の異常）

文永堂 2007.03 （ ISBN:978-4-8300-3209-7 ）

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Total pages：312 Responsible for pages：241-257 Book type：Textbook, survey, introduction
獣医繁殖学第3版

川手憲俊（ Role： Joint author）

文永堂 2006.09

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Responsible for pages：215-221 Book type：Textbook, survey, introduction
獣医繁殖学マニュアル

澤田勉, 玉田尋通, 川手憲俊（ Role： Joint author）

文永堂 2004.03

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Responsible for pages：219-238 Book type：Textbook, survey, introduction

Outline of collaborative research (seeds)

Applicatin of INSL3 in domestic animals
黒毛和種子牛の発育・栄養状態と生殖機能の発達との関連性解析

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黒毛和種子牛の発育・栄養状態と生殖機能の発達との関連性解析

Grant-in-Aid for Scientific Research

雌ウシのINSL3分泌動態および生殖器・生殖細胞における受容体発現と役割の解明

Grant-in-Aid for Scientific Research(C) 2022
雌ウシのINSL3分泌動態および生殖器・生殖細胞における受容体発現と役割の解明

Grant-in-Aid for Scientific Research(C) 2021
精巣・代謝ホルモンと精子結合蛋白質解析による和牛の精液不良の原因解明と改善法開発

Grant-in-Aid for Scientific Research(C) 2018
精巣・代謝ホルモンと精子結合蛋白質解析による和牛の精液不良の原因解明と改善法開発

Grant-in-Aid for Scientific Research(C) 2017
精巣・代謝ホルモンと精子結合蛋白質解析による和牛の精液不良の原因解明と改善法開発

Grant-in-Aid for Scientific Research(C) 2016
飼育動物の生殖器疾患等におけるINSL3測定の臨床検査への応用と同受容体発現解析

Grant-in-Aid for Scientific Research(C) 2015
飼育動物の生殖器疾患等におけるINSL3測定の臨床検査への応用と同受容体発現解析

Grant-in-Aid for Scientific Research(C) 2013
イヌとウシの血中インスリン様ペプチド３の免疫測定法の確立と精巣機能検査への応用

Grant-in-Aid for Scientific Research(C) 2012
イヌとウシの血中インスリン様ペプチド３の免疫測定法の確立と精巣機能検査への応用

Grant-in-Aid for Scientific Research(C) 2011
Elucidation of roles and signal transduction of INSL3 in bovine gamate maturaiton, fertilization and embryo development

Grant-in-Aid for Scientific Research(C) 2026
Elucidation of roles and signal transduction of INSL3 in bovine gamate maturaiton, fertilization and embryo development

Grant-in-Aid for Scientific Research(C) 2025
Elucidation of roles and signal transduction of INSL3 in bovine gamate maturaiton, fertilization and embryo development

Grant-in-Aid for Scientific Research(C) 2024
Studies on expressions and roles of INSL3 secretory dynamics and its receptor expression in reproductive organs and germ cells in female cattle

Grant-in-Aid for Scientific Research(C) 2024

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Contract research

雄アジアゾウの攻撃的行動”マスト”を薬剤で阻止する技術の開発に関する基盤的研究

独立行政法人日本学術振興会二国間交流事業（共同研究） 2016
雄アジアゾウの攻撃的行動”マスト”を薬剤で阻止する技術の開発に関する基盤的研究

独立行政法人日本学術振興会二国間交流事業（共同研究） 2015
雄アジアゾウの攻撃的行動”マスト”を薬剤で阻止する技術の開発に関する基盤的研究

独立行政法人日本学術振興会二国間交流事業（共同研究） 2014

Incentive donations / subsidies

性ホルモンワクチンによるスリランカ雄アジアゾウのマスト（攻撃的行動）の抑制解析と技術確立

公益財団法人平和中島財団アジア地域重点学術研究助成 2014

Charge of on-campus class subject

獣医繁殖学A

2022 Weekly class Undergraduate
獣医繁殖学B

2022 Weekly class Undergraduate
獣医繁殖学実習

2022 Weekly class Undergraduate
産業動物生産獣医療

2022 Weekly class Undergraduate
牧場実習

2022 Intensive lecture Undergraduate
畜産学実習

2022 Intensive lecture Undergraduate
大動物診療実習

2022 Intensive lecture Undergraduate
大動物野外診療実習

2022 Intensive lecture Undergraduate
獣医繁殖学A

2024 Weekly class Undergraduate
小動物基礎臨床実習

2024 Intensive lecture Undergraduate
獣医学関連法規

2024 Weekly class Undergraduate
獣医臨床栄養学

2024 Weekly class Undergraduate
獣医科学特別演習2

2024 Intensive lecture Graduate school
獣医科学特別演習1

2024 Intensive lecture Graduate school
生産獣医療学特論

2024 Intensive lecture Graduate school
獣医臨床科学特別研究G

2024 Intensive lecture Graduate school
獣医臨床科学特別研究E

2024 Intensive lecture Graduate school
獣医臨床科学特別研究C

2024 Intensive lecture Graduate school
獣医臨床科学特別研究A

2024 Intensive lecture Graduate school
獣医臨床科学特別演習C

2024 Intensive lecture Graduate school
獣医臨床科学特別演習A

2024 Intensive lecture Graduate school
産業動物生産獣医療

2024 Weekly class Undergraduate
獣医科学英語演習

2024 Intensive lecture Undergraduate
Field Practice for Large Animal Clinics

2021 Practical Training
Large Animal Practice A

2021 Practical Training
Veterinary Hygiene A

2021
Special Lecture: Advanced Pathobiology C

2021
Special Lecture: Veterinary Clinical Sciences

2021
Practical Training for Food production

2021 Practical Training
Practice for Large Animal Clinics

2021 Practical Training
Field Practice for Large Animal Clinics

2021 Practical Training
Stock Farm Practice

2021 Practical Training
Large Animal Practice B

2021
Large Animal Practice A

2021 Practical Training
Large Animal Practice A

2021 Practical Training
Large Animal Practice A

2021 Practical Training
Veterinary Cardiovascular & Respiratory Medicine

2021
Theriogenology A

2021
Veterinary Clinical Nutrition

2021
Practice in Theriogenology

2021 Practical Training
Introduction to Life, Environment, and Advanced Sciences

2021
Farm Animal Production Medicine

2021
Introduction to Veterinary Medicine

2021
Basic clinical practices

2021 Practical Training

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Academic Activities

Journal of Veterinary Medical Science Theriogenology Editor

2018.11 - 2022.10