Updated on 2022/07/13

写真a

 
TAKENAKA Shigeo
 
Organization
Graduate School of Human Life and Ecology Division of Human Life and Ecology Professor
School of Human Life and Ecology Department of Nutrition
Title
Professor
Affiliation
Institute of Human Life and Ecology
Contact information
メールアドレス

Position

  • Graduate School of Human Life and Ecology Division of Human Life and Ecology 

    Professor  2022.04 - Now

  • School of Human Life and Ecology Department of Nutrition 

    Professor  2022.04 - Now

Degree

  • 博士(農学) ( Others )

Research Areas

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living  / Food and Nutrition

  • Life Science / Applied biochemistry  / Applied biological chemistry

  • Life Science / Food sciences  / Food Science

Research subject summary

  • 神経軸索伸長因子の作用機構解析

  • ビタミンB12の機能性

  • メタボローム解析による病態診断法の開発

Research Career

  • Understanding of vitamin B12 functions in pathological condition

    vtamin B12, cobalamin, nerve, differntiation, metabolism 

  • Development of diagnosis medthods by metabolic profiling with mass spectrometry

    metabolic profiling, mass spectrometry, dagnosis, toxicology, pathology 

Professional Memberships

  • 日本医用マススペクトロメトリー学会

    2010.04 - Now   Domestic

  • 日本獣医学会

    2002.04 - Now   Domestic

  • AmericanSocietyForCellBiology

    2001.06 - Now   Overseas

  • 日本分子生物学会

    1994.04 - Now   Domestic

  • 日本農芸化学会

    1992.04 - Now   Domestic

  • 日本栄養食糧学会

    1992.04 - Now   Domestic

  • 日本ビタミン学会

    1992.04 - Now   Domestic

  • 日本生化学会

    1992.04 - Now   Domestic

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Papers

  • Structural and functional analysis of gum arabic l-rhamnose-α-1,4-d-glucuronate lyase establishes a novel polysaccharide lyase family Reviewed

    Kondo T., Kichijo, M., Maruta, A., Nakaya, M., Takenaka, S., Arakawa, T., Fushinobu, S., & Sakamoto, T.

    J. Biol. Chem. 雑誌   297   2021.09

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    Kind of work:Joint Work  

  • Characterization of Vitamin B12 Compounds in Fermented Poultry Manure Fertilizers Reviewed

    Katsura, H., Koseki, K., Bito, T., Takenaka, S. and Watanabe, F.

    Agriculture 雑誌   11 ( 7 )   2021.07

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    Kind of work:Joint Work  

  • Changes in Smad1/5/9 expression and phosphorylation in astrocytes of the rat hippocampus after transient global cerebral ischemia Reviewed

    Nakajima, T., Kunieda, Y., Takahashia, Y., Tanaka, Y., Kondo, T., Takenaka, S.

    J Chem Neuroanat . 雑誌   113   2021.04

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    Kind of work:Joint Work  

  • Liquid chromatography-tandem mass spectrometry analysis of oxidation of 2'-, 3'-, 4'- and 6-hydroxyflavanones by human cytochrome P450 enzymes Reviewed

    Shimada, T., Nagayoshi, H., Murayama, N., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, FP.

    Xenobiotica 雑誌   51 ( 2 )   2021.02

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    Kind of work:Joint Work  

  • Preference for O-demethylation reactions in the oxidation of 2'-, 3'-, and 4'-methoxyflavones by human cytochrome P450 enzymes Reviewed

    Nagayoshi, H., Murayama, N., Tsujino, M., Takenaka, S., Katahira, J., Kim, V., Kim, D., Komori, M., Yamazaki, H., Guengerich, FP, Shimada, T.

    Xenobiotica 雑誌   50 ( 10 )   2020.10

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    Kind of work:Joint Work  

  • Determination and characterization of vitamin B12 in the muscles and head innards of edible shrimp Reviewed

    Okamoto, N., Hamaguchi, N., Umebayashi, Y., Takenaka, S., Bito, T. & Watanabe, F.

    Fish. Sci. 雑誌   86   2020.03

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    Kind of work:Joint Work  

  • The Relationship between Serum Vitamin E Level and Risk Factors for Arteriosclerosis in Japanese Postmenopausal Women. Reviewed

    Nakatsu, Y., Niida, S., Tanaka, K., Takenaka, S., Kuwabara, A.

    J Nutr Sci Vitaminol (Tokyo). 雑誌   66   2020.03

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    Kind of work:Joint Work  

  • Oxidation of Flavone, 5-Hydroxyflavone, and 5,7-Dihydroxyflavone to Mono-, Di-, and Tri-Hydroxyflavones by Human Cytochrome P450 Enzymes. Reviewed

    Nagayoshi H, Murayama N, Kakimoto K, Tsujino M, Takenaka S, Katahira J, Lim YR, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T.

    Chem Res Toxicol. 雑誌   32   1268 - 1280   2019

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    Kind of work:Joint Work  

  • Downregulation of aspartoacylase during the progression of myelin breakdown in the dmy mutant rat with mitochondrial magnesium channel MRS2 defect. Reviewed

    Kuwamura M, Tanimura S, Hasegawa Y, Hoshiai R, Moriyama Y, Tanaka M, Takenaka S, Nagayoshi H, Izawa T, Yamate J, Kuramoto T, Serikawa T.

    Brain Res. 雑誌   1718   169 - 175   2019

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    Kind of work:Joint Work  

  • Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants. Reviewed

    Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M.

    Xenobiotica 雑誌   48   565 - 575   2018

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    Kind of work:Joint Work  

  • Cytochrome P450 2A6 and other human P450 enzymes in the oxidation of flavone and flavanone. Reviewed

    Kakimoto K, Murayama N, Takenaka S, Nagayoshi H, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T.

    Xenobiotica 雑誌   49   131 - 142   2018

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    Kind of work:Joint Work  

  • Site-specific oxidation of flavanone and flavone by cytochrome P450 2A6 in human liver microsomes. Reviewed

    Nagayoshi H, Murayama N, Kakimoto K, Takenaka S, Katahira J, Lim YR, Kim V, Kim D, Yamazaki H, Komori M, Guengerich FP, Shimada T.

    Xenobiotica 雑誌   49   791 - 802   2018

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    Kind of work:Joint Work  

  • Expression of Ccdc85C, a causative protein for murine hydrocephalus, in the mammary gland tumors of dogs. Reviewed

    Tanaka N, Izawa T, Takenaka S, Akiyoshi H, Yamate J, Kuwamura M.

    Histol. Histopathol. 雑誌   22   397 - 403   2017

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    Kind of work:Joint Work  

  • Purification, characterization, and overexpression of an endo-1,4-β-mannanase from thermotolerant Bacillus sp. SWU60. Reviewed

    Seesom W, Thongket P, Yamamoto T, Takenaka S, Sakamoto T, Sukhumsirichart W.

    World J Microbiol Biotechnol. 雑誌   33   53 - 57   2017

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    Kind of work:Joint Work  

  • Physiological functions of pyruvate:NADP+ oxidoreductase and 2-oxoglutarate decarboxylase in Euglena gracilis under aerobic and anaerobic conditions. Reviewed

    Nakazawa M, Hayashi R, Takenaka S, Inui H, Ishikawa T, Ueda M, Sakamoto T, Nakano Y, Miyatake K.

    Biosci Biotechnol Biochem. 雑誌   81   1386 - 1393   2017

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    Kind of work:Joint Work  

  • Oxidation of 1-chloropyrene by human CYP1 family and CYP2A subfamily cytochrome P450 enzymes: catalytic roles of two CYP1B1 and five CYP2A13 allelic variants. Reviewed

    Shimada T, Murayama N, Kakimoto K, Takenaka S, Lim YR, Yeom S, Kim D, Yamazaki H, Guengerich FP, Komori M.

    Xenobiotica 雑誌   21   1 - 11   2017

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    Kind of work:Joint Work  

  • Roles of Human CYP2A6 and Monkey CYP2A24 and 2A26 Cytochrome P450 Enzymes in the Oxidation of 2,5,2',5'-Tetrachlorobiphenyl. Reviewed

    Shimada T, Kakimoto K, Takenaka S, Koga N, Uehara S, Murayama N, Yamazaki H, Kim D, Guengerich FP, Komori M.

    Drug Metab Dispos. 雑誌   44   1899 - 1909   2017

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    Kind of work:Joint Work  

  • Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13 Reviewed

    Shimada, T., Takenaka, S., Murayama, N., Kramlinger V.M., Kim, J.H. Kim, D., Liu, J., Forozesh, M.K., Yamazaki, H., Guengerich, F.P. and Komori, M.

    Xenobiotica 雑誌   46   211 - 224   2016

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    Kind of work:Joint Work  

  • Production of feline leukemia inhibitory factor with biological activity in Escherichia coli. Reviewed

    Kanegi R, Hatoya S, Tsujimoto Y, Takenaka S, Nishimura T, Wijewardana V, Sugiura K, Takahashi M, Kawate N, Tamada H, and Inaba T.

    Theriogenol. 雑誌   86   604 - 611   2016

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    Kind of work:Joint Work  

  • 1’-Acetoxychavicol Acetate Ameliorates Age-related Spatial Memory Deterioration by Increasing Serum Ketone Body Production as a Complementary Energy Source for Neuronal Cells Reviewed

    Kojima-Yuasa, A., Yamamoto, T., Yaku, K., Hirota, S., Takenaka, S., Kawabe, K., and Matsui-Yuasa, I.

    Chem. Biol. Interact. 雑誌   25   101 - 109   2016

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    Kind of work:Joint Work  

  • Identification of Eimeria acervulina conoid antigen using chicken monoclonal antibody Reviewed

    Matsubayashi, M., Minoura, C., Kimura, S., Tani, H., Furuya, M., Lillehoj, H.S., Matsuda, H., Takenaka, S., Hatta, T., Tsuji, N. and Sasai, K.

    Parasitol. Res. 雑誌   115   4123 - 4126   2016

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    Kind of work:Joint Work  

  • Structure-Function Studies of Naphthalene, Phenanthrene, Biphenyl, and Their Derivatives in Interaction with and Oxidation by Cytochromes P450 2A13 and 2A6. Reviewed

    Shimada T, Takenaka S, Kakimoto K, Murayama N, Lim YR, Kim D, Foroozesh MK, Yamazaki H, Guengerich FP, Komori M.

    Chem Res Toxicol. 雑誌   29   1029 - 1040   2016

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    Kind of work:Joint Work  

  • Involvement of aspartoacylase in tremor expression in rats Reviewed

    Nishitani A, Tanaka M, Shimizu S, Kunisawa N, Yokoe M, Yoshida Y, Suzuki T, Sakuma T, Yamamoto T, Kuwamura M, Takenaka S, Ohono Y, Kuramoto T.

    Exp Anim. 雑誌   65   293 - 301   2016

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    Kind of work:Joint Work  

  • Molecular characterization of a Penicillium chrysogenum exo-rhamnogalacturonan lyase that is structurally distinct from other polysaccharide lyase family proteins.

    Iwai M, Kawakami T, Ikemoto T, Fujiwara D, Takenaka S, Nakazawa M, Ueda M, Sakamoto T.

    Appl Microbiol Biotechnol 雑誌   99   2015

  • Determination and characterization of corrinoid compounds in truffle (Tuber spp.) and shoro (Rhizopogon rubescens) fruiting bodies. Reviewed

    Teng, F., Bito, T., Takenaka, S., yabuta, Y., Shimomura, N. and Watanabe, F.

    Mushroom Sci. Biotech. 雑誌   22   159 - 164   2015

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    Kind of work:Joint Work  

  • Proteomic analysis of the hippocampus in naïve and ischemic-preconditioned rat. Reviewed

    Nakajima, T, Hata, R, Kondo, T, Takenaka, S.

    J Neuro Sci. 雑誌   358   2015

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    Kind of work:Joint Work  

  • Localization of heat shock protein 110 in canine mammary gland tumors

    Okada, S., Furuya, M., Takenaka, S., Fukui, A., Matsubayashi, M., Tani, H., Sasai, K.

    Vet Immunol Immunopathol. 雑誌   167   2015

  • Urinary metabolic fingerprinting for α-naphthylisothiocyanate-induced intrahepatic cholestasis in rats using Fourier transform-ion cyclotron resonance mass spectrometry Reviewed

    Hasegawa, M., Ide, M., Fujita, T. and Takenaka, S.

    Toxicol. Phathol. 雑誌   36   818 - 826   2008

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    Kind of work:Joint Work  

  • Slit3 regulates cell motility through Rac/Cdc42 activation in lipopolysaccharide-stimulated macrophages. Reviewed

    Tanno T, Fujiwara A, Sakaguchi K, Tanaka K, Takenaka S, Tsuyama S.

    FEBS Lett. 雑誌   581   1022 - 6   2007

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    Kind of work:Joint Work  

  • Determination of unique amino acid substitutions in protein variants by peptide mass mapping with FT-ICR MS. Reviewed

    Tanaka, K., Takenaka, S., Tsuyama, S. and Wada, Y.

    J. Am. Soc. Mass Spectorm. 雑誌   17   508 - 513   2006.04

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    Kind of work:Joint Work  

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Books and Other Publications

  • 改訂 獣医生化学

    横田博(編著) 、 木村和弘(編著)、 志水泰武(編著)、 竹中重雄、 杉谷博士、 藤田秋一、 他15名( Role: Joint author)

    朝倉書店  2016.04 

Charge of on-campus class subject

  • Special Topics in Nutrition Biochemistry

    2021    

  • Exercise in International Food Circulation

    2021    

  • International Circulation of Food and Dietary

    2021    

  • Thesis

    2021    

  • Biology A

    2021    

  • Cell Biology

    2021    

  • Biochemistry

    2021    

  • Topics in Nutrition Biochemistry

    2021    

  • Practice in Food Processing

    2021   Practical Training  

  • Food Science (Laboratory)

    2021   Practical Training  

  • Biochemistry and Molecular Biology (Laboratory)

    2021   Practical Training  

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