Updated on 2023/05/12

写真a

 
Yasu-Taka Azuma
 
Organization
Graduate School of Veterinary Science Department of Veterinary Science Professor
School of Veterinary Science Department of Veterinary Science
Title
Professor
Affiliation
Institute of Veterinary Science
Affiliation campus
Rinku Campus

Position

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Professor  2022.04 - Now

  • School of Veterinary Science Department of Veterinary Science 

    Professor  2022.04 - Now

Degree

  • 博士(獣医学)

  • 博士(歯学) ( Others )

  • 修士(薬学) ( Others )

Research Areas

  • Life Science / Immunology  / Inflammatory Disease

  • Life Science / Gastroenterology  / Inflammatory Bowel Disease

  • Life Science / Veterinary medical science  / Mucosal Immunology

Research subject summary

  • IL-19の免疫学的役割

  • 免疫系細胞におけるカルシウムシグナリングの役割解明

  • NASH発症機構の解明

  • 膵炎発症機構の解明

  • IBD発症機構の解明

Job Career (off-campus)

  • 大阪府立大学大学院生命環境科学研究科教授

    2021 - Now

Papers

  • L-arginine-induced pancreatitis aggravated by inhibiting Na(+)/Ca(2+) exchanger 1.

    Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Kuwamura M, Azuma YT

    The Journal of veterinary medical science   2023.04( ISSN:0916-7250

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  • Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon.

    Ono N, Suzuki S, Kawada K, Yamaguchi T, Azuma YT

    The Journal of veterinary medical science   84 ( 8 )   1061 - 1064   2022.08( ISSN:0916-7250

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  • Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.

    Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Yuri Kato, Takahiro Shibata, Hiroshi Tanaka, Hitoshi Kurose, Yasu-Taka Azuma, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Koji Uchida, Motohiro Nishida

    Science signaling   15 ( 716 )   eabj0644   2022.01

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    After ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent desensitization, during which they are internalized and either degraded or recycled to the plasma membrane. Some GPCRs are not subject to this type of desensitization because they lack the residues required to interact with β-arrestins. We identified a mechanism of redox-dependent alternative internalization (REDAI) that promotes the internalization and degradation of the purinergic P2Y6 receptor (P2Y6R). Synthetic and natural compounds containing electrophilic isothiocyanate groups covalently modified P2Y6R at Cys220, which promoted the ubiquitylation of Lys137 and receptor internalization and degradation in various mouse and human cultured cell lines. Endogenous electrophiles also promoted ligand-dependent P2Y6R internalization and degradation. P2Y6R is highly abundant in inflammatory cells and promotes the pathogenesis of colitis. Deficiency in P2Y6R protected mice against experimentally induced colitis, and mice expressing a form of P2Y6R in which Cys220 was mutated to nonmodifiable serine were more sensitive to the induction of colitis. Several other GPCRs, including A2BAR, contain cysteine and lysine residues at the appropriate positions to mediate REDAI, and isothiocyanate stimulated the internalization of A2BAR and of a form of P2Y2R with insertions of the appropriate residues. Thus, endogenous and exogenous electrophiles may limit colitis progression through cysteine modification of P2Y6R and may also mediate internalization of other GPCRs.

    DOI: 10.1126/scisignal.abj0644

    PubMed

  • Recent topics on interorgan communication networks and gut microbiota

    Ono Naoshige, Azuma Yasu-Taka

    Folia Pharmacologica Japonica   157 ( 5 )   321 - 324   2022( ISSN:00155691

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    <p>The living body is composed of diverse organ systems, each of which has its own characteristic control mechanisms and complex in vivo responses. Between the brain and organs such as the heart, kidney, liver, pancreas, gastrointestinal tract, and even muscles, there is a sophisticated and complex regulatory system. Coordinated interactions through communication between organs are essential for maintaining health. In this review, we introduce four research trends in inter-organ networks, with a focus on the digestive system: 1) Inter-organ networks on metabolic systems, 2) Inter-organ networks originating from the gastrointestinal tract, 3) Intestinal bacteria, that is one of the biggest topics in recent years, 4) Research results on the involvement of gut microbiota in the inter-organ network between the kidney and the gastrointestinal tract. An integrated understanding and investigation of the regulatory mechanisms of inter-organ communication networks are expected to extend healthy life span and improve quality of life.</p>

    DOI: 10.1254/fpj.22038

    PubMed

  • IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.

    Yasu-Taka Azuma, Takashi Fujita, Takeshi Izawa, Kana Hirota, Kazuhiro Nishiyama, Airi Ikegami, Tomoko Aoyama, Mikihito Ike, Yumi Ushikai, Mitsuru Kuwamura, Hideki Fujii, Koichi Tsuneyama

    Cells   10 ( 12 )   2021.12

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Interleukin (IL)-19, a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by macrophages. Nonalcoholic steatohepatitis (NASH) is a disease that has progressed from nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation and fibrosis. We evaluated the functions of IL-19 in a NAFLD/NASH mouse model using a 60% high fat diet with 0.1% methionine, without choline, and with 2% cholesterol (CDAHFD). Wild-type (WT) and IL-19 gene-deficient (KO) mice were fed a CDAHFD or standard diet for 9 weeks. Liver injury, inflammation, and fibrosis induced by CDAHFD were significantly worse in IL-19 KO mice than in WT mice. IL-6, TNF-α, and TGF-β were significantly higher in IL-19 KO mice than in WT mice. As a mechanism using an in vitro experiment, palmitate-induced triglyceride and cholesterol contents were decreased by the addition of IL-19 in HepG2 cells. Furthermore, addition of IL-19 decreased the expression of fatty acid synthesis-related enzymes and increased ATP content in HepG2 cells. The action of IL-19 in vitro suppressed lipid metabolism. In conclusion, IL-19 may play an important role in the development of steatosis and fibrosis by directly regulating liver metabolism and may be a potential target for the treatment of liver diseases.

    DOI: 10.3390/cells10123513

    PubMed

  • IL-19 contributes to the development of nonalcoholic steatohepatitis by altering lipid metabolism. Reviewed

    1. Azuma YT, Fujita T, Izawa T, Hirota K, Nishiyama K, Ikegami A, Aoyama T, Ike M, Ushikai Y, Kuwamura M, Fujii H, Tsuneyama K.

    Cells 雑誌   10 ( 12 )   2021.12

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    Kind of work:Joint Work  

  • IL-19の抗炎症作用を活かした治療への応用 Reviewed

    小野尚重,東 泰孝

    日本薬理学雑誌 雑誌   156 ( 5 )   288 - 291   2021.05

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    Kind of work:Joint Work  

  • Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel. Reviewed

    Azuma YT, Suzuki S, Nishiyama K, Yamaguchi T.

    J. Vet. Med. Sci. 雑誌   83 ( 4 )   622 - 629   2021.04

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    Kind of work:Joint Work  

  • Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel.

    Yasu-Taka Azuma, Sho Suzuki, Kazuhiro Nishiyama, Taro Yamaguchi

    The Journal of veterinary medical science   2021.02

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    Excessive stress response causes disability in social life. There are many diseases caused by stress, such as gastrointestinal motility disorders, depression, eating disorders, and cardiovascular diseases. Transient receptor potential (TRP) channels underlie non-selective cation currents and are downstream effectors of G protein-coupled receptors. Ca2+ influx is important for smooth muscle contraction, which is responsible for gastrointestinal motility. Little is known about the possible involvement of TRP channels in the gastrointestinal motility disorders due to stress. The purpose of this study was to measure the changes in gastrointestinal motility caused by stress and to elucidate the mechanism of these changes. The stress model used the water immersion restraint stress. Gastrointestinal motility, especially the ileum, was recorded responses to electric field stimulation (EFS) by isometric transducer. EFS-induced contraction was significantly reduced in the ileum of stressed mouse. Even under the conditions treated with atropine, EFS-induced contraction was significantly reduced in the ileum of stressed mouse. In addition, carbachol-induced, neurokinin A-induced, and substance P-induced contractions were all significantly reduced in the ileum of stressed mouse. Furthermore, the expression of TRPC3 was decreased in the ileum of stressed mouse. These results suggest that the gastrointestinal motility disorders due to stress is associated with specific non-selective cation channel.

    DOI: 10.1292/jvms.20-0490

    PubMed

  • Interleukin-19 as an immunoregulatory cytokine. Reviewed

    Fujimoto Y, Kuramoto N, Yoneyama M, Azuma YT.

    Curr. Mol. Pharmacol. 雑誌   14 ( 2 )   191 - 199   2021.02

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    Kind of work:Joint Work  

  • Interleukin-19 abrogates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation. Reviewed

    Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, Azuma YT, Tanaka F, Suzumura A, Takeuchi H.

    Front. Immunol. 雑誌   12   2021

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    Kind of work:Joint Work  

  • Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis. Reviewed

    Komiya H, Takeuchi H, Ogawa Y, Suzuki K, Ogasawara A, Takahashi K, Azuma YT, Doi H, Tanaka F.

    Molecular Brain 雑誌   14 ( 1 )   2021

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    Kind of work:Joint Work  

  • Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure. Reviewed

    Fujimoto Y, Kuwamura M, Azuma YT.

    J. Vet. Med. Sci. 雑誌   82 ( 10 )   1450 - 1455   2020.10

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    Kind of work:Joint Work  

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7. Reviewed

    Gütschow M, Vanden Eynde JJ, Jampílek J, Kang CB, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D.

    Molecules 雑誌   2020.07

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    Kind of work:Joint Work  

  • Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice. Reviewed

    Yasu-Taka Azuma, Kazuhiro Nishiyama

    The Journal of veterinary medical science   2020.05

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    Authorship:Corresponding author   International / domestic magazine:Domestic journal  

    Interleukin (IL)-19 is a cytokine of the IL-10 family. There are many reports on the involvement of IL-19 in several human diseases. There also are many reports elucidating the role of IL-19 using mouse disease models. Most reports use C57BL/6 mice, whereas few reports use BALB/c mice, in terms of the mouse disease model that the researchers used in the present study. To date, research on the role of IL-19 is diversified, yet some basic mechanisms are still unclear. In this study, we administered lipopolysaccharide (LPS), polyI:C, and CpG to BALB/c mice, measured more than 20 cytokines in the blood and compared them with that of the wild-type and IL-19-deficient (IL-19 KO) mice. LPS is associated with bacterial infection, polyI:C is associated with viral infection, and CpG is associated with both bacterial and viral infections. Among the cytokines measured, the results of experiments using LPS revealed that the production of some cytokines was suppressed in IL-19 KO mice. Interestingly, the experiments using polyI:C revealed that production of some cytokines was enhanced in IL-19 KO mice. However, the experiments using CpG have shown that the production of only one cytokine was enhanced in IL-19 KO mice. These results revealed that cytokine production in the blood was regulated by IL-19, and the type of regulation was dependent on the administered stimulant.

    DOI: 10.1292/jvms.20-0137

    PubMed

  • Interleukin-19 as an immunoregulatory cytokine

    Yasuyuki Fujimoto, Nobuyuki Kuramoto, Masanori Yoneyama, Yasu-Taka Azuma

    Current Molecular Pharmacology   13   2020.04( ISSN:1874-4672

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    Publishing type:Research paper (scientific journal)  

    <sec>
    <title>:</title>
    IL-19 is a type of anti-inflammatory cytokine. Since the receptor for IL-19 is common
    to IL-20 and IL-24, it is important to clarify the role of each of the three. If three
    different cytokines bind to the same receptor, these three may have been produced to
    complement the other two. However perhaps it is unlikely. Recently, the existence of a
    novel receptor for IL-19 was suggested. The distinction between the three roles still
    makes sense. On the other hand, because T cells do not produce IL-19, their role in
    acquired immunity is limited or indirect. It has been reported that IL-19 causes
    inflammation in some diseases but is not an anti-inflammatory effect. In this review, we
    introduce the current role of IL-19 in each disease. In addition, we will describe the
    molecular mechanism of IL-19 and its development for prevention. IL-19 was
    previously considered an anti-inflammatory cytokine, but we would like to propose
    what we call an immunoregulatory cytokine.



    </sec>

    DOI: 10.2174/1874467213666200424151528

  • Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells Reviewed

    Chika Natsume, Nao Aoki, Tomoko Aoyama, Keisuke Senda, Mio Matsui, Airi Ikegami, Kosuke Tanaka, Yasu-Taka Azuma, Takashi Fujita

    International Journal of Molecular Sciences   21 ( 6 )   2180 - 2180   2020.03

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    Publishing type:Research paper (scientific journal)  

    Fucoxanthin (FX) is a xanthophyll that is contained abundantly in marine plants. The biological action of FX includes its antioxidant and anti-lipogenic activities, while the precise action of its mechanisms on skin cells has not yet been clarified. The current study examined the effect of FX in comparison with tacrolimus (TAC) on NC/Nga mice, which are an atopic dermatitis (AD) model. FX topical treatment dramatically ameliorated itching behavior over the TAC treatment, which was insufficient for improvement of AD symptoms. In Nc/Nga mice, FX or TAC applied to the skin inhibited eosinophil infiltration with decreased expression of Il-33. FX also stimulated Il-2, Il-5, Il-13, Il-10, and TGF-β expression levels, and Sca1+Il-10+TGF-β+ regulatory innate lymphoid cells (ILCreg) were dominantly observed in FX treated skin epidermal keratinocytes and dermal layers. This combined evidence demonstrated that FX exerts anti-inflammatory effects on keratinocytes and ameliorates AD symptoms by regulating ILCreg to normalize immune responses in an atopic dermatitis model.

    DOI: 10.3390/ijms21062180

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. Reviewed

    Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D.

    Molecules 雑誌   2020.01

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    Kind of work:Joint Work  

  • Fucoxanthin ameliorates atopic dermatitis symptoms by regulating keratinocytes and regulatory innate lymphoid cells. Reviewed

    Natsume C, Aoki N, Aoyama T, Senda K, Matsui M, Ikegami A, Tanaka K, Azuma YT, Fujita T.

    Int J Mol Sci 雑誌   2020

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    Kind of work:Joint Work  

  • Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice. Reviewed

    Azuma YT, Nishiyama K.

    J Vet Med Sci 雑誌   2020

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    Kind of work:Joint Work  

  • Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure Reviewed

    Yasuyuki FUJIMOTO, Mitsuru KUWAMURA, Yasu-Taka AZUMA

    Journal of Veterinary Medical Science   82 ( 10 )   1450 - 1455   2020( ISSN:0916-7250

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1292/jvms.20-0344

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes. Reviewed

    Kazuhiro Nishiyama, Takuro Numaga-Tomita, Yasuyuki Fujimoto, Tomohiro Tanaka, Chiemi Toyama, Akiyuki Nishimura, Tomohiro Yamashita, Naoya Matsunaga, Satoru Koyanagi, Yasu-Taka Azuma, Yuko Ibuki, Koji Uchida, Shigehiro Ohdo, Motohiro Nishida

    British journal of pharmacology   176 ( 18 )   3723 - 3738   2019.09( ISSN:0007-1188

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    BACKGROUND AND PURPOSE: Doxorubicin is a highly effective anticancer agent but eventually induces cardiotoxicity associated with increased production of ROS. We previously reported that a pathological protein interaction between TRPC3 channels and NADPH oxidase 2 (Nox2) contributed to doxorubicin-induced cardiac atrophy in mice. Here we have investigated the effects of ibudilast, a drug already approved for clinical use and known to block doxorubicin-induced cytotoxicity, on the TRPC3-Nox2 complex. We specifically sought evidence that this drug attenuated doxorubicin-induced systemic tissue wasting in mice. EXPERIMENTAL APPROACH: We used the RAW264.7 macrophage cell line to screen 1,271 clinically approved chemical compounds, evaluating functional interactions between TRPC3 channels and Nox2, by measuring Nox2 protein stability and ROS production, with and without exposure to doxorubicin. In male C57BL/6 mice, samples of cardiac and gastrocnemius muscle were taken and analysed with morphometric, immunohistochemical, RT-PCR and western blot methods. In the passive smoking model, cells were exposed to DMEM containing cigarette sidestream smoke. KEY RESULTS: Ibudilast, an anti-asthmatic drug, attenuated ROS-mediated muscle toxicity induced by doxorubicin treatment or passive smoking, by inhibiting the functional interactions between TRPC3 channels and Nox2, without reducing TRPC3 channel activity. CONCLUSIONS AND IMPLICATIONS: These results indicate a common mechanism underlying induction of systemic tissue wasting by doxorubicin. They also suggest that ibudilast could be repurposed to prevent muscle toxicity caused by anticancer drugs or passive smoking.

    DOI: 10.1111/bph.14777

    PubMed

  • Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. Reviewed

    Kazuhiro Nishiyama, Kimiya Aono, Yasuyuki Fujimoto, Mitsuru Kuwamura, Toshiya Okada, Hayato Tokumoto, Takeshi Izawa, Ryoichi Okano, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu-Taka Azuma

    Journal of cellular physiology   234 ( 5 )   6667 - 6678   2019.05( ISSN:0021-9541

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    International / domestic magazine:International journal  

    Organ-organ crosstalk is involved in homeostasis. Gastrointestinal symptoms are common in patients with renal failure. The aim of this study was to elucidate the relationship between gastrointestinal motility and gastrointestinal symptoms in chronic kidney disease. We performed studies in C57BL/6 mice with chronic kidney disease after 5/6 nephrectomy. Gastrointestinal motility was evaluated by assessing the ex vivo responses of ileum and distal colon strips to electrical field stimulation. Feces were collected from mice, and the composition of the gut microbiota was analyzed using 16S ribosomal RNA sequencing. Mice with chronic kidney disease after 5/6 nephrectomy showed a decreased amount of stool, and this constipation was correlated with a suppressed contraction response in ileum motility and decreased relaxation response in distal colon motility. Spermine, one of the uremic toxins, inhibited the contraction response in ileum motility, but four types of uremic toxins showed no effect on the relaxation response in distal colon motility. The 5/6 nephrectomy procedure disturbed the balance of the gut microbiota in the mice. The motility dysregulation and constipation were resolved by antibiotic treatments. The expression levels of interleukin 6, tumor necrosis factor-α, and iNOS in 5/6 nephrectomy mice were increased in the distal colon but not in the ileum. In addition, macrophage infiltration in 5/6 nephrectomy mice was increased in the distal colon but not in the ileum. We found that 5/6 nephrectomy altered gastrointestinal motility and caused constipation by changing the gut microbiota and causing colonic inflammation. These findings indicate that renal failure was remarkably associated with gastrointestinal dysregulation.

    DOI: 10.1002/jcp.27408

    PubMed

  • Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases. Reviewed

    Kimiya Aono, Yasu-Taka Azuma, Tomoyo Nabetani, Shingo Hatoya, Masaru Furuya, Mariko Miki, Kana Hirota, Yasuyuki Fujimoto, Kazuhiro Nishiyama, Yoshiyuki Ogata, Tomofumi Mochizuki, Hiroyuki Tani

    Veterinary immunology and immunopathology   210   15 - 22   2019.04( ISSN:0165-2427

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    International / domestic magazine:International journal  

    Toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain 2 (NOD2), and TNF-α play important roles in human inflammatory bowel diseases. The aim of this study was to elucidate the relationship between Toll-like receptor 4, NOD2, and TNF-α and the severity of chronic gastrointestinal diseases in dogs. We examined the expression levels of TLR4, NOD2, and TNF-α in the stomach, duodenum, ileum, colon, and rectum obtained from 21 dogs with chronic gastrointestinal disease, including inflammatory bowel disease, high-grade lymphoma, food responsive enteropathy, chronic pancreatitis, low-grade lymphoma, inflammatory colorectal polyp, and chronic colitis. Next, we demonstrated whether there is good correlation between the expression levels of TLR4, NOD2, and TNF-α and the histopathological analysis of each sample. We found that the level of TLR4 expression in the ileum of dogs with chronic gastrointestinal disease was positively associated with the histopathological severity. We also found that the level of NOD2 expression in the duodenum, stomach, and rectum was positively associated with the histopathological severity. However, there was no correlation between TNF-α expression in the 5 regions tested in this study and the histopathological severity. These findings indicate that TLR4 and NOD2 are remarkably associated with the severity of chronic gastrointestinal disease in dogs.

    DOI: 10.1016/j.vetimm.2019.03.003

    PubMed

  • Chronic kidney disease following 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. Reviewed

    Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT.

    J Cell Physiol 雑誌   234 ( 5 )   6667 - 6678   2019

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    Kind of work:Joint Work  

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex. Reviewed

    Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M.

    Br J Pharmacol 雑誌   2019

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    Kind of work:Joint Work  

  • Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases. Reviewed

    Aono K, Azuma YT, Nabetani T, Hatoya S, Furuya M, Miki M, Hirota K, Fujimoto Y, Nishiyama K, Ogata Y, Mochizuki T, Tani H.

    Veterinary Immunology and Immunopathology 雑誌   210   15 - 22   2019

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    Kind of work:Joint Work  

  • Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling. Reviewed

    Nishiyama K, Fujita T, Fujimoto Y, Nakajima H, Takeuchi T, Azuma YT.

    Int Immunopharmacol 雑誌   55   205 - 215   2018

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    Kind of work:Joint Work  

  • Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPR40-dependent pathway. Reviewed

    Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Azuma YT, Nakamura Y.

    Neurochemical Research 雑誌   43 ( 9 )   723 - 1735   2018

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    Kind of work:Joint Work  

  • The Role of Interleukin-19 in Contact Hypersensitivity. Reviewed

    Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.

    Biol Pharma Bull 雑誌   41 ( 2 )   182 - 189   2018

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    Kind of work:Joint Work  

  • Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo. Reviewed

    4. Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T.

    Biochem Biophys Res Commun 雑誌   2017.03

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    Kind of work:Joint Work  

  • Na+/Ca2+ exchanger contribute to stool transport in mice with experimental diarrhea Reviewed

    Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T

    J Vet Med Sci 雑誌   2017.02

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    Kind of work:Joint Work  

  • Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. Reviewed

    Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA.

    World J Cardiol 雑誌   9 ( 8 )   673 - 684   2017

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  • Exacerbated experimental pancreatitis in interleukin-19 knockout mice. Reviewed

    Fujimoto Y, Tsuneyama K, Kuramoto N, Hayashi S, Yoshida N, Morioka A, Teramoto M, Nakajima H, Takeuchi T, Azuma YT.

    Glob Drugs Therap 雑誌   2 ( 5 )   1 - 5   2017

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    Kind of work:Joint Work  

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MISC

  • 【腸内細菌と心血管疾患:新たな病態機序】臓器間ネットワークと腸内細菌に関する最近の話題

    小野 尚重, 東 泰孝

    日本薬理学雑誌   157 ( 5 )   321 - 324   2022.09( ISSN:0015-5691

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    生体は,多様な器官系から構成されており,それぞれの器官系が特徴的な制御機構を持ち,複雑な生体内応答を示す.脳と心臓,腎臓,肝臓,膵臓,消化管,さらには筋肉といった各臓器間には,巧妙で複雑な制御システムが存在する.健康維持には,臓器間のコミュニケーションによる協調的な相互作用が欠かせない.本総説では,消化器系を中心に置いて,そこから拡がる臓器間ネットワークに関する研究動向について紹介する.まず,代謝系に関する臓器間ネットワークについて紹介し,次いで,消化管を起点とする臓器間ネットワークについて紹介し,続いて,近年最大のトピックの一つである腸内細菌について紹介する.消化管運動を調節する機構は複雑でその詳細は明らかとなっていない.一方で,消化管運動は他の臓器の活動状態により様々な影響を受ける.この臓器間ネットワークによる消化管運動変調に関与する因子を明らかにすることは,消化管運動調節機構を理解するうえで重要な視点となる.腎不全患者では嘔吐,下痢,あるいは便秘などの消化器症状が認められることから,消化管と腎臓の間には相互に密接な連関があるが,これまでに消化管運動機能に影響する機構は明らかになっていなかった.そこで,最後に,腎臓と消化管間の臓器間ネットワークにおける腸内細菌の関与に関する研究成果を紹介する.(著者抄録)

  • 【基礎研究の臨床応用とアカデミア創薬への新規展開】IL-19の抗炎症作用を活かした治療への応用

    小野 尚重, 東 泰孝

    日本薬理学雑誌   156 ( 5 )   288 - 291   2021.09( ISSN:0015-5691

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    インターロイキン19(IL-19)は,IL-10ファミリーの一員であり,主にマクロファージや単球,上皮細胞,血管平滑筋細胞によって産生されるサイトカインであり,さらに多くの細胞種からも産生される.産生する細胞が多岐に渡るため,IL-19の役割も多面的であるが,主な役割の一つとして,1型ヘルパーT細胞(Th1)を介する免疫応答およびTh2を介する免疫応答の両方に関与するユニークな働きを持つサイトカインである.この作用も免疫系細胞と非免疫系細胞の両方からIL-19が産生される事実と関連している.IL-19の受容体はIL-20受容体1および2から成るヘテロ二量体であり,IL-10ファミリーの他のメンバーであるIL-20およびIL-24と受容体をシェアする.2000年に発見されたIL-19であるが,当初10年ほどの研究成果により,乾癬などの皮膚疾患,喘息などの呼吸器疾患,ならびに動脈硬化症などの循環器疾患などを中心に人疾患あるいはマウスモデルにおける抗炎症的役割が解明された.2013年ごろからは,マウス疾患モデルにおけるIL-19の治療的役割に関する研究報告が相次ぐようになり,IL-19の応用展開に注目が集まる.本総説では,動脈硬化症モデルマウスを用いたIL-19の予防的効果ならびに治療的効果に関する研究成果を紹介し,人疾患への応用展開を視野に入れつつあるIL-19の最新研究動向について述べる.(著者抄録)

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

    Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, CongBao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J. H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdiero, Jean-Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu-Taka Azuma, Laura Cerchia, Mariana Spetea, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A. R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A. C. Gomes, Rita C. Guedes, Jean-Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero

    Molecules   25 ( 13 )   2968 - 2968   2020.06( eISSN:1420-3049

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    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]

    DOI: 10.3390/molecules25132968

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

    Jean Jacques Vanden Eynde, Arduino A. Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso T. García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula A. C. Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Laura Cerchia, Jean-Marc Sabatier, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, F. Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, M. Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília de Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Carlo Siciliano, Stefania Galdiero, Hong Liu, Peter J. H. Scott, Cristóbal de los Ríos, Luigi A. Agrofoglio, Simona Collina, Rita C. Guedes, Diego Muñoz-Torrero

    Molecules   25 ( 1 )   119 - 119   2019.12( eISSN:1420-3049

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    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials that is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]

    DOI: 10.3390/molecules25010119

  • 【健康寿命の延伸に向けた生活習慣病とがん研究の新展開】多臓器に着目したインターロイキン-19による新規炎症調節機能

    藤本 泰之, 東 泰孝

    日本薬理学雑誌   154 ( 2 )   66 - 71   2019.08( ISSN:0015-5691

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    生体の恒常性は神経系と内分泌系の二大ネットワークにより維持されるのは周知の事実であるが、サイトカインをシグナル伝達物質とする免疫系のネットワークは生体の恒常性維持のみならず、炎症性疾患の病態形成に特に重要である。近年、先進国を中心に患者数の増加が著しいメタボリックシンドロームに代表される代謝性疾患においてもサイトカイン応答を機転とする炎症応答が病態の発生・進展に関与する報告がなされており、従来の病態発症機構とは異なる視点からの理解が進みつつある。これらサイトカインおよびその下流シグナルを新しい標的とした治療薬開発が期待され、事実、世界中で開発競争が熱を帯びてきている。今回、数多くあるサイトカインの中でもIL-19の各種炎症関連疾患に対する新規機能について概説する。IL-19はESTアッセイによりIL-10のホモログとして同定されたサイトカインである。同定の経緯よりIL-19はIL-10ファミリーに分類され、IL-20、IL-24およびIL-26と共にIL-20サブファミリーを形成する。各種研究成果の内、IL-19はTh2応答に対して増強作用を示すことから、アレルギー疾患等のTh2関連疾患への関与が示唆されている。近年では、Th17応答に伴うIL-19産生が乾癬の病態形成に寄与する報告が複数の異なる研究グループから相次いでいること、またIL-19投与が種々の炎症病態に対して抗炎症作用を示し、病態を改善することも報告されている。これまでのところ、IL-19は病態依存的に炎症促進あるいは抗炎症作用を発揮することから、IL-19は生体において多面的な作用を有する重要なサイトカインの一つであることが明らかとなってきた。本総説では、種々の炎症関連疾患(乾癬、アトピー性皮膚炎、関節リウマチおよび炎症性腸疾患)におけるIL-19発現動態および機能について近年の新規知見を概説する。(著者抄録)

  • Recent progress in the pathophysiological role of interleukin-19 Reviewed

    Yasuyuki Fujimoto, Yasu-Taka Azuma

    Nihon yakurigaku zasshi.   154 ( 2 )   66 - 71   2019( ISSN:0015-5691 ( eISSN:1347-8397

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    Authorship:Corresponding author  

    DOI: 10.1254/fpj.154.66

  • The clarified role of interleukin-19 in the inflammatory bowel disease and hypersensitivity: Insights from animal models and humans Reviewed

    Yasuyuki FUJIMOTO, Kimiya AONO, Yasu-Taka AZUMA

    Journal of Veterinary Medical Science   81 ( 8 )   1067 - 1073   2019( ISSN:0916-7250 ( eISSN:1347-7439

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    Authorship:Corresponding author  

    DOI: 10.1292/jvms.19-0149

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Outline of collaborative research (seeds)

  • NASHモデルマウスを用いた治療作用点の解析

  • 膵炎モデルマウスを用いた治療作用点の解析

  • アレルギーモデルを用いた治療作用点の解析

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    遅発性アレルギーモデルである①DTHテスト、②接触性皮膚炎を用いた治療作用点の解析

  • IBDモデルマウスを用いた治療作用点の解析

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    IBDモデルマウスとして①DSS誘導性腸炎、②TNBS誘導性腸炎、③オキサゾロン誘導性腸炎)を用いた治療作用点の解析

Charge of on-campus class subject

  • Veterinary Pharmacology B

    2021    

  • Laws and Regulations concerning Veterinary Science

    2021    

  • Veterinary Clinical Pharmacology

    2021    

  • Fundamental Experiments of Biology

    2021   Practical Training  

  • Practice in Veterinary Pharmacology

    2021   Practical Training  

  • Animal Physiology on Basic

    2021    

  • Veterinary Pharmacology B

    2021    

  • Veterinary Pharmacology B

    2021    

  • Veterinary Pharmacology A

    2021    

  • Biology B

    2021    

  • Basic clinical practices

    2021   Practical Training  

  • Veterinary English

    2021    

  • Special Lecture: Integrated Functional Biosciences B

    2021    

  • Practice in Feasibility Study on Drug Discovery

    2021   Practical Training  

  • Introduction to Drug Discovery and Development

    2021    

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Job title

  • Job title within the department

    Graduate School of Veterinary Science Department of Veterinary Science 

    専攻長  2023.04

  • Job title within the department

    School of Veterinary Science Department of Veterinary Science 

    学科長  2022.04

  • Job title within the department

    Graduate School of Veterinary Science Department of Veterinary Science 

    専攻長  2022.04 - 2023.03