2024/03/14 更新

写真a

アズマ　ヤスタカ
東　泰孝
Yasu-Taka Azuma
担当
大学院獣医学研究科 獣医学専攻 教授
獣医学部 獣医学科
職名
教授
所属
獣医学研究院
所属キャンパス
りんくうキャンパス

担当・職階

  • 大学院獣医学研究科 獣医学専攻 

    教授  2022年04月 - 継続中

  • 獣医学部 獣医学科 

    教授  2022年04月 - 継続中

取得学位

  • 博士（獣医学）

  • 博士（歯学） （ 大阪歯科大学 ）

  • 修士（薬学） （ 摂南大学 ）

研究分野

  • ライフサイエンス / 免疫学  / 炎症性疾患

  • ライフサイエンス / 消化器内科学  / 炎症性腸疾患

  • ライフサイエンス / 獣医学  / 消化器免疫

  • ライフサイエンス / 薬理学

研究キーワード

  • NASH・肝炎

  • 炎症性腸疾患

  • サイトカイン

  • マクロファージ

  • 炎症性疾患

  • 消化器疾患

  • マウス病態モデル

  • インターロイキン-19（IL-19）

  • 臓器連関

研究概要

  • IL-19の免疫学的役割

  • 免疫系細胞におけるカルシウムシグナリングの役割解明

  • MASH/MAFLD発症機構の解明

  • 消化管と肝臓間の臓器連関機構の解明

  • IBD発症機構の解明

研究歴

  • インターロイキン-19の免疫学的役割の解明

    個人研究

    1992年10月 - 継続中 

職務経歴（学外）

  • 大阪公立大学大学院獣医学研究科教授

    2022年04月 - 継続中

  • 大阪府立大学大学院生命環境科学研究科教授

    2021年04月 - 2022年03月

論文

  • Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

    Nishiyama K, Kato Y, Nishimura A, Mi X, Nagata R, Mori Y, Azuma YT, Nishida M

    International journal of molecular sciences   25 ( 4 )   2024年02月

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国際誌  

    DOI： 10.3390/ijms25042401

    PubMed

  • Functional role of IL-19 in a mouse model of L-arginine-induced pancreatitis and related lung injury.

    Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Fujita T, Kuwamura M, Azuma YT

    Experimental animals   2023年12月（ ISSN:0007-5124 ）

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国内誌  

    DOI： 10.1538/expanim.23-0094

    PubMed

  • Interleukin-19 Gene-Deficient Mice Promote Liver Fibrosis via Enhanced TGF-β Signaling, and the Interleukin-19-CCL2 Axis Is Important in the Direction of Liver Fibrosis.

    Ono N, Fujita T, Miki M, Nishiyama K, Izawa T, Aoyama T, Kuwamura M, Fujii H, Azuma YT

    Biomedicines   11 ( 7 )   2023年07月（ ISSN:2227-9059 ）

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国際誌  

    DOI： 10.3390/biomedicines11072064

    PubMed

  • L-arginine-induced pancreatitis aggravated by inhibiting Na(+)/Ca(2+) exchanger 1.

    Ono N, Horikoshi J, Izawa T, Nishiyama K, Tanaka M, Kuwamura M, Azuma YT

    The Journal of veterinary medical science   85 ( 6 )   657 - 666   2023年04月（ ISSN:0916-7250 ）

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国内誌  

    DOI： 10.1292/jvms.22-0569

    PubMed

  • Stress decreases contraction of the colon, and the effects of stress are different among the regions of the colon.

    Ono N, Suzuki S, Kawada K, Yamaguchi T, Azuma YT

    The Journal of veterinary medical science   84 ( 8 )   1061 - 1064   2022年08月（ ISSN:0916-7250 ）

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  • Redox-dependent internalization of the purinergic P2Y6 receptor limits colitis progression.

    Kazuhiro Nishiyama, Akiyuki Nishimura, Kakeru Shimoda, Tomohiro Tanaka, Yuri Kato, Takahiro Shibata, Hiroshi Tanaka, Hitoshi Kurose, Yasu-Taka Azuma, Hideshi Ihara, Yoshito Kumagai, Takaaki Akaike, Philip Eaton, Koji Uchida, Motohiro Nishida

    Science signaling   15 ( 716 )   eabj0644   2022年01月

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国際誌  

    After ligand stimulation, many G protein–coupled receptors (GPCRs) undergo β-arrestin–dependent desensitization, during which they are internalized and either degraded or recycled to the plasma membrane. Some GPCRs are not subject to this type of desensitization because they lack the residues required to interact with β-arrestins. We identified a mechanism of redox-dependent alternative internalization (REDAI) that promotes the internalization and degradation of the purinergic P2Y6 receptor (P2Y6R). Synthetic and natural compounds containing electrophilic isothiocyanate groups covalently modified P2Y6R at Cys220, which promoted the ubiquitylation of Lys137 and receptor internalization and degradation in various mouse and human cultured cell lines. Endogenous electrophiles also promoted ligand-dependent P2Y6R internalization and degradation. P2Y6R is highly abundant in inflammatory cells and promotes the pathogenesis of colitis. Deficiency in P2Y6R protected mice against experimentally induced colitis, and mice expressing a form of P2Y6R in which Cys220 was mutated to nonmodifiable serine were more sensitive to the induction of colitis. Several other GPCRs, including A2BAR, contain cysteine and lysine residues at the appropriate positions to mediate REDAI, and isothiocyanate stimulated the internalization of A2BAR and of a form of P2Y2R with insertions of the appropriate residues. Thus, endogenous and exogenous electrophiles may limit colitis progression through cysteine modification of P2Y6R and may also mediate internalization of other GPCRs.

    DOI： 10.1126/scisignal.abj0644

    PubMed

  • 臓器間ネットワークと腸内細菌に関する最近の話題

    小野 尚重, 東 泰孝

    日本薬理学雑誌   157 ( 5 )   321 - 324   2022年（ ISSN:00155691 ）

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    <p>生体は，多様な器官系から構成されており，それぞれの器官系が特徴的な制御機構を持ち，複雑な生体内応答を示す．脳と心臓，腎臓，肝臓，膵臓，消化管，さらには筋肉といった各臓器間には，巧妙で複雑な制御システムが存在する．健康維持には，臓器間のコミュニケーションによる協調的な相互作用が欠かせない．本総説では，消化器系を中心に置いて，そこから拡がる臓器間ネットワークに関する研究動向について紹介する．まず，代謝系に関する臓器間ネットワークについて紹介し，次いで，消化管を起点とする臓器間ネットワークについて紹介し，続いて，近年最大のトピックの一つである腸内細菌について紹介する．消化管運動を調節する機構は複雑でその詳細は明らかとなっていない．一方で，消化管運動は他の臓器の活動状態により様々な影響を受ける．この臓器間ネットワークによる消化管運動変調に関与する因子を明らかにすることは，消化管運動調節機構を理解するうえで重要な視点となる．腎不全患者では嘔吐，下痢，あるいは便秘などの消化器症状が認められることから，消化管と腎臓の間には相互に密接な連関があるが，これまでに消化管運動機能に影響する機構は明らかになっていなかった．そこで，最後に，腎臓と消化管間の臓器間ネットワークにおける腸内細菌の関与に関する研究成果を紹介する．</p>

    DOI： 10.1254/fpj.22038

    PubMed

  • IL-19 Contributes to the Development of Nonalcoholic Steatohepatitis by Altering Lipid Metabolism.

    Yasu-Taka Azuma, Takashi Fujita, Takeshi Izawa, Kana Hirota, Kazuhiro Nishiyama, Airi Ikegami, Tomoko Aoyama, Mikihito Ike, Yumi Ushikai, Mitsuru Kuwamura, Hideki Fujii, Koichi Tsuneyama

    Cells   10 ( 12 )   2021年12月

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国際誌  

    Interleukin (IL)-19, a member of the IL-10 family, is an anti-inflammatory cytokine produced primarily by macrophages. Nonalcoholic steatohepatitis (NASH) is a disease that has progressed from nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation and fibrosis. We evaluated the functions of IL-19 in a NAFLD/NASH mouse model using a 60% high fat diet with 0.1% methionine, without choline, and with 2% cholesterol (CDAHFD). Wild-type (WT) and IL-19 gene-deficient (KO) mice were fed a CDAHFD or standard diet for 9 weeks. Liver injury, inflammation, and fibrosis induced by CDAHFD were significantly worse in IL-19 KO mice than in WT mice. IL-6, TNF-α, and TGF-β were significantly higher in IL-19 KO mice than in WT mice. As a mechanism using an in vitro experiment, palmitate-induced triglyceride and cholesterol contents were decreased by the addition of IL-19 in HepG2 cells. Furthermore, addition of IL-19 decreased the expression of fatty acid synthesis-related enzymes and increased ATP content in HepG2 cells. The action of IL-19 in vitro suppressed lipid metabolism. In conclusion, IL-19 may play an important role in the development of steatosis and fibrosis by directly regulating liver metabolism and may be a potential target for the treatment of liver diseases.

    DOI： 10.3390/cells10123513

    PubMed

  • IL-19の抗炎症作用を活かした治療への応用 査読

    小野尚重，東　泰孝

    日本薬理学雑誌 雑誌   156 ( 5 )   288 - 291   2021年05月

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    共著区分：共著  

  • Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel.

    Yasu-Taka Azuma, Sho Suzuki, Kazuhiro Nishiyama, Taro Yamaguchi

    The Journal of veterinary medical science   2021年02月

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国内誌  

    Excessive stress response causes disability in social life. There are many diseases caused by stress, such as gastrointestinal motility disorders, depression, eating disorders, and cardiovascular diseases. Transient receptor potential (TRP) channels underlie non-selective cation currents and are downstream effectors of G protein-coupled receptors. Ca2+ influx is important for smooth muscle contraction, which is responsible for gastrointestinal motility. Little is known about the possible involvement of TRP channels in the gastrointestinal motility disorders due to stress. The purpose of this study was to measure the changes in gastrointestinal motility caused by stress and to elucidate the mechanism of these changes. The stress model used the water immersion restraint stress. Gastrointestinal motility, especially the ileum, was recorded responses to electric field stimulation (EFS) by isometric transducer. EFS-induced contraction was significantly reduced in the ileum of stressed mouse. Even under the conditions treated with atropine, EFS-induced contraction was significantly reduced in the ileum of stressed mouse. In addition, carbachol-induced, neurokinin A-induced, and substance P-induced contractions were all significantly reduced in the ileum of stressed mouse. Furthermore, the expression of TRPC3 was decreased in the ileum of stressed mouse. These results suggest that the gastrointestinal motility disorders due to stress is associated with specific non-selective cation channel.

    DOI： 10.1292/jvms.20-0490

    PubMed

  • Interleukin-19 as an immunoregulatory cytokine. 査読

    Fujimoto Y, Kuramoto N, Yoneyama M, Azuma YT.

    Curr. Mol. Pharmacol. 雑誌   14 ( 2 )   191 - 199   2021年02月

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    共著区分：共著  

  • Interleukin-19 abrogates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation. 査読

    Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, Azuma YT, Tanaka F, Suzumura A, Takeuchi H.

    Front. Immunol. 雑誌   12   2021年

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    共著区分：共著  

  • Ablation of interleukin-19 improves motor function in a mouse model of amyotrophic lateral sclerosis. 査読

    Komiya H, Takeuchi H, Ogawa Y, Suzuki K, Ogasawara A, Takahashi K, Azuma YT, Doi H, Tanaka F.

    Molecular Brain 雑誌   14 ( 1 )   2021年

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    共著区分：共著  

  • Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure. 査読

    Fujimoto Y, Kuwamura M, Azuma YT.

    J. Vet. Med. Sci. 雑誌   82 ( 10 )   1450 - 1455   2020年10月

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    共著区分：共著  

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7. 査読

    Gütschow M, Vanden Eynde JJ, Jampílek J, Kang CB, Mangoni AA, Fossa P, Karaman R, Trabocchi A, Scott PJH, Reynisson J, Rapposelli S, Galdiero S, Winum JY, Brullo C, Prokai-Tatrai K, Sharma AK, Schapira M, Azuma YT, Cerchia L, Spetea M, Torri G, Collina S, Geronikaki A, García-Sosa AT, Vasconcelos MH, Sousa ME, Kosalec I, Tuccinardi T, Duarte IF, Salvador JAR, Bertinaria M, Pellecchia M, Amato J, Rastelli G, Gomes PAC, Guedes RC, Sabatier JM, Estévez-Braun A, Pagano B, Mangani S, Ragno R, Kokotos G, Brindisi M, González FV, Borges F, Miloso M, Rautio J, Muñoz-Torrero D.

    Molecules 雑誌   2020年07月

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    共著区分：共著  

  • Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice. 査読

    Yasu-Taka Azuma, Kazuhiro Nishiyama

    The Journal of veterinary medical science   2020年05月

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    担当区分：責任著者   国際・国内誌：国内誌  

    Interleukin (IL)-19 is a cytokine of the IL-10 family. There are many reports on the involvement of IL-19 in several human diseases. There also are many reports elucidating the role of IL-19 using mouse disease models. Most reports use C57BL/6 mice, whereas few reports use BALB/c mice, in terms of the mouse disease model that the researchers used in the present study. To date, research on the role of IL-19 is diversified, yet some basic mechanisms are still unclear. In this study, we administered lipopolysaccharide (LPS), polyI:C, and CpG to BALB/c mice, measured more than 20 cytokines in the blood and compared them with that of the wild-type and IL-19-deficient (IL-19 KO) mice. LPS is associated with bacterial infection, polyI:C is associated with viral infection, and CpG is associated with both bacterial and viral infections. Among the cytokines measured, the results of experiments using LPS revealed that the production of some cytokines was suppressed in IL-19 KO mice. Interestingly, the experiments using polyI:C revealed that production of some cytokines was enhanced in IL-19 KO mice. However, the experiments using CpG have shown that the production of only one cytokine was enhanced in IL-19 KO mice. These results revealed that cytokine production in the blood was regulated by IL-19, and the type of regulation was dependent on the administered stimulant.

    DOI： 10.1292/jvms.20-0137

    PubMed

  • Interleukin-19 as an immunoregulatory cytokine

    Yasuyuki Fujimoto, Nobuyuki Kuramoto, Masanori Yoneyama, Yasu-Taka Azuma

    Current Molecular Pharmacology   13   2020年04月（ ISSN:1874-4672 ）

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    掲載種別：研究論文（学術雑誌）  

    <sec>
    <title>:</title>
    IL-19 is a type of anti-inflammatory cytokine. Since the receptor for IL-19 is common
    to IL-20 and IL-24, it is important to clarify the role of each of the three. If three
    different cytokines bind to the same receptor, these three may have been produced to
    complement the other two. However perhaps it is unlikely. Recently, the existence of a
    novel receptor for IL-19 was suggested. The distinction between the three roles still
    makes sense. On the other hand, because T cells do not produce IL-19, their role in
    acquired immunity is limited or indirect. It has been reported that IL-19 causes
    inflammation in some diseases but is not an anti-inflammatory effect. In this review, we
    introduce the current role of IL-19 in each disease. In addition, we will describe the
    molecular mechanism of IL-19 and its development for prevention. IL-19 was
    previously considered an anti-inflammatory cytokine, but we would like to propose
    what we call an immunoregulatory cytokine.



    </sec>

    DOI： 10.2174/1874467213666200424151528

  • Fucoxanthin Ameliorates Atopic Dermatitis Symptoms by Regulating Keratinocytes and Regulatory Innate Lymphoid Cells 査読

    Chika Natsume, Nao Aoki, Tomoko Aoyama, Keisuke Senda, Mio Matsui, Airi Ikegami, Kosuke Tanaka, Yasu-Taka Azuma, Takashi Fujita

    International Journal of Molecular Sciences   21 ( 6 )   2180 - 2180   2020年03月

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    掲載種別：研究論文（学術雑誌）  

    Fucoxanthin (FX) is a xanthophyll that is contained abundantly in marine plants. The biological action of FX includes its antioxidant and anti-lipogenic activities, while the precise action of its mechanisms on skin cells has not yet been clarified. The current study examined the effect of FX in comparison with tacrolimus (TAC) on NC/Nga mice, which are an atopic dermatitis (AD) model. FX topical treatment dramatically ameliorated itching behavior over the TAC treatment, which was insufficient for improvement of AD symptoms. In Nc/Nga mice, FX or TAC applied to the skin inhibited eosinophil infiltration with decreased expression of Il-33. FX also stimulated Il-2, Il-5, Il-13, Il-10, and TGF-β expression levels, and Sca1+Il-10+TGF-β+ regulatory innate lymphoid cells (ILCreg) were dominantly observed in FX treated skin epidermal keratinocytes and dermal layers. This combined evidence demonstrated that FX exerts anti-inflammatory effects on keratinocytes and ameliorates AD symptoms by regulating ILCreg to normalize immune responses in an atopic dermatitis model.

    DOI： 10.3390/ijms21062180

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-6. 査読

    Vanden Eynde JJ, Mangoni AA, Rautio J, Leprince J, Azuma YT, García-Sosa AT, Hulme C, Jampilek J, Karaman R, Li W, Gomes PAC, Hadjipavlou-Litina D, Capasso R, Geronikaki A, Cerchia L, Sabatier JM, Ragno R, Tuccinardi T, Trabocchi A, Winum JY, Luque FJ, Prokai-Tatrai K, Spetea M, Gütschow M, Kosalec I, Guillou C, Vasconcelos MH, Kokotos G, Rastelli G, de Sousa ME, Manera C, Gemma S, Mangani S, Siciliano C, Galdiero S, Liu H, Scott PJH, de Los Ríos C, Agrofoglio LA, Collina S, Guedes RC, Muñoz-Torrero D.

    Molecules 雑誌   2020年01月

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    共著区分：共著  

  • Fucoxanthin ameliorates atopic dermatitis symptoms by regulating keratinocytes and regulatory innate lymphoid cells. 査読

    Natsume C, Aoki N, Aoyama T, Senda K, Matsui M, Ikegami A, Tanaka K, Azuma YT, Fujita T.

    Int J Mol Sci 雑誌   2020年

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    共著区分：共著  

  • Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice. 査読

    Azuma YT, Nishiyama K.

    J Vet Med Sci 雑誌   2020年

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    共著区分：共著  

  • Deficiency of interleukin-19 exacerbates lipopolysaccharide/D-galactosamine-induced acute liver failure 査読

    Yasuyuki FUJIMOTO, Mitsuru KUWAMURA, Yasu-Taka AZUMA

    Journal of Veterinary Medical Science   82 ( 10 )   1450 - 1455   2020年（ ISSN:0916-7250 ）

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    担当区分：責任著者   掲載種別：研究論文（学術雑誌）  

    DOI： 10.1292/jvms.20-0344

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex. 査読

    Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M

    British journal of pharmacology   176 ( 18 )   3723 - 3738   2019年09月（ ISSN:0007-1188 ）

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    掲載種別：研究論文（学術雑誌）   国際・国内誌：国際誌  

    DOI： 10.1111/bph.14777

    PubMed

  • Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. 査読

    Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT

    Journal of cellular physiology   234 ( 5 )   6667 - 6678   2019年05月（ ISSN:0021-9541 ）

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    国際・国内誌：国際誌  

    DOI： 10.1002/jcp.27408

    PubMed

  • Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases. 査読

    Aono K, Azuma YT, Nabetani T, Hatoya S, Furuya M, Miki M, Hirota K, Fujimoto Y, Nishiyama K, Ogata Y, Mochizuki T, Tani H

    Veterinary immunology and immunopathology   210   15 - 22   2019年04月（ ISSN:0165-2427 ）

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    国際・国内誌：国際誌  

    DOI： 10.1016/j.vetimm.2019.03.003

    PubMed

  • Chronic kidney disease following 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. 査読

    Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT.

    J Cell Physiol 雑誌   234 ( 5 )   6667 - 6678   2019年

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    共著区分：共著  

  • Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3-Nox2 protein complex. 査読

    Nishiyama K, Numaga-Tomita T, Fujimoto Y, Tanaka T, Toyama C, Nishimura A, Yamashita T, Matsunaga N, Koyanagi S, Azuma YT, Ibuki Y, Uchida K, Ohdo S, Nishida M.

    Br J Pharmacol 雑誌   2019年

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    共著区分：共著  

  • Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases. 査読

    Aono K, Azuma YT, Nabetani T, Hatoya S, Furuya M, Miki M, Hirota K, Fujimoto Y, Nishiyama K, Ogata Y, Mochizuki T, Tani H.

    Veterinary Immunology and Immunopathology 雑誌   210   15 - 22   2019年

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    共著区分：共著  

  • Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling. 査読

    Nishiyama K, Fujita T, Fujimoto Y, Nakajima H, Takeuchi T, Azuma YT.

    Int Immunopharmacol 雑誌   55   205 - 215   2018年

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    共著区分：共著  

  • Lauric acid alleviates neuroinflammatory responses by activated microglia: involvement of the GPR40-dependent pathway. 査読

    Nishimura Y, Moriyama M, Kawabe K, Satoh H, Takano K, Azuma YT, Nakamura Y.

    Neurochemical Research 雑誌   43 ( 9 )   723 - 1735   2018年

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    共著区分：共著  

  • The Role of Interleukin-19 in Contact Hypersensitivity. 査読

    Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.

    Biol Pharma Bull 雑誌   41 ( 2 )   182 - 189   2018年

    　詳細を見る

    共著区分：共著  

  • Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo. 査読

    4. Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T.

    Biochem Biophys Res Commun 雑誌   2017年03月

    　詳細を見る

    共著区分：共著  

  • Na+/Ca2+ exchanger contribute to stool transport in mice with experimental diarrhea 査読

    Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T

    J Vet Med Sci 雑誌   2017年02月

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    共著区分：共著  

  • Interleukin-19 is cardioprotective in dominant negative cyclic adenosine monophosphate response-element binding protein-mediated heart failure in a sex-specific manner. 査読

    Bruns DR, Ghincea AR, Ghincea CV, Azuma YT, Watson PA, Autieri MV, Walker LA.

    World J Cardiol 雑誌   9 ( 8 )   673 - 684   2017年

    　詳細を見る

    共著区分：共著  

  • Exacerbated experimental pancreatitis in interleukin-19 knockout mice. 査読

    Fujimoto Y, Tsuneyama K, Kuramoto N, Hayashi S, Yoshida N, Morioka A, Teramoto M, Nakajima H, Takeuchi T, Azuma YT.

    Glob Drugs Therap 雑誌   2 ( 5 )   1 - 5   2017年

    　詳細を見る

    共著区分：共著  

▼全件表示

MISC（その他記事）

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

    Michael Gütschow, Jean Jacques Vanden Eynde, Josef Jampilek, CongBao Kang, Arduino A. Mangoni, Paola Fossa, Rafik Karaman, Andrea Trabocchi, Peter J. H. Scott, Jóhannes Reynisson, Simona Rapposelli, Stefania Galdiero, Jean-Yves Winum, Chiara Brullo, Katalin Prokai-Tatrai, Arun K. Sharma, Matthieu Schapira, Yasu-Taka Azuma, Laura Cerchia, Mariana Spetea, Giangiacomo Torri, Simona Collina, Athina Geronikaki, Alfonso T. García-Sosa, M. Helena Vasconcelos, Maria Emília Sousa, Ivan Kosalec, Tiziano Tuccinardi, Iola F. Duarte, Jorge A. R. Salvador, Massimo Bertinaria, Maurizio Pellecchia, Jussara Amato, Giulio Rastelli, Paula A. C. Gomes, Rita C. Guedes, Jean-Marc Sabatier, Ana Estévez-Braun, Bruno Pagano, Stefano Mangani, Rino Ragno, George Kokotos, Margherita Brindisi, Florenci V. González, Fernanda Borges, Mariarosaria Miloso, Jarkko Rautio, Diego Muñoz-Torrero

    Molecules   25 ( 13 )   2968 - 2968   2020年06月（ eISSN:1420-3049 ）

    　詳細を見る

    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of editorials which is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]

    DOI： 10.3390/molecules25132968

  • Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

    Jean Jacques Vanden Eynde, Arduino A. Mangoni, Jarkko Rautio, Jérôme Leprince, Yasu-Taka Azuma, Alfonso T. García-Sosa, Christopher Hulme, Josef Jampilek, Rafik Karaman, Wei Li, Paula A. C. Gomes, Dimitra Hadjipavlou-Litina, Raffaele Capasso, Athina Geronikaki, Laura Cerchia, Jean-Marc Sabatier, Rino Ragno, Tiziano Tuccinardi, Andrea Trabocchi, Jean-Yves Winum, F. Javier Luque, Katalin Prokai-Tatrai, Mariana Spetea, Michael Gütschow, Ivan Kosalec, Catherine Guillou, M. Helena Vasconcelos, George Kokotos, Giulio Rastelli, Maria Emília de Sousa, Clementina Manera, Sandra Gemma, Stefano Mangani, Carlo Siciliano, Stefania Galdiero, Hong Liu, Peter J. H. Scott, Cristóbal de los Ríos, Luigi A. Agrofoglio, Simona Collina, Rita C. Guedes, Diego Muñoz-Torrero

    Molecules   25 ( 1 )   119 - 119   2019年12月（ eISSN:1420-3049 ）

    　詳細を見る

    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials that is published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]

    DOI： 10.3390/molecules25010119

講演・口頭発表等

  • 脂質代謝におけるインターロイキン-19の新規調節機構

    東 泰孝

    肝臓  2022年09月  (一社)日本肝臓学会

  • 小腸消化管運動におけるストレス負荷に伴う収縮反応の抑制．

    東　泰孝、山口太郎

    第140回日本薬理学会近畿部会  2021年11月 

    　詳細を見る

    会議種別：ポスター発表  

  • インターロイキン-19は四塩化炭素による肝線維化形成に関与する． 国内会議

    小野尚重、三木万梨子、東　泰孝

    第140回日本薬理学会近畿部会  2021年11月 

    　詳細を見る

    会議種別：ポスター発表  

  • Therapeutic application utilizing the anti-inflammatory effect of IL-19. 国内会議

    東　泰孝

    第94回日本薬理学会年  2021年03月 

    　詳細を見る

    会議種別：ポスター発表  

産学官連携可能研究（シーズ）概要

  • NASHモデルマウスを用いた治療作用点の解析

  • アレルギーモデルを用いた治療作用点の解析

    　詳細を見る

    遅発性アレルギーモデルである①DTHテスト、②接触性皮膚炎を用いた治療作用点の解析

  • IBDモデルマウスを用いた治療作用点の解析

    　詳細を見る

    IBDモデルマウスとして①DSS誘導性腸炎、②TNBS誘導性腸炎、③オキサゾロン誘導性腸炎）を用いた治療作用点の解析

担当授業科目

  • 獣医薬理学Ｂ

    2021年度    

  • 獣医学関連法規

    2021年度    

  • 獣医臨床薬理学

    2021年度    

  • 生物学実験

    2021年度   実習  

  • 獣医薬理学実習

    2021年度   実習  

  • 基礎動物生理学

    2021年度    

  • 獣医薬理学Ｂ

    2021年度    

  • 獣医薬理学Ｂ

    2021年度    

  • 獣医薬理学Ａ

    2021年度    

  • 生物学Ｂ

    2021年度    

  • 臨床基礎実習

    2021年度   実習  

  • 獣医科学英語

    2021年度    

  • 統合バイオ機能学特別講義Ｂ

    2021年度    

  • 創薬フィージビリティ研究実習

    2021年度   実習  

  • 創薬学概論

    2021年度    

▼全件表示

ＦＤ活動

  • 口演発表  2023年度

    　詳細を見る

    9月12日に開催された「大阪公立大学におけるFDのあり方について考える（２）」において、「複数の担当教員による成績評価のバラツキから学べること」の演題名にて発表を行った。

  • 成果報告  2022年度

    　詳細を見る

    「薬理学関連科目の成績評価に関する年次推移」の論文名にて、大阪公立大学「大学教育」第１巻に掲載した。

論文・研究指導集計

  • 2023年度

    博士論文審査数（主査）：1件 

  • 2023年度

    博士後期課程学生指導数：1名

役職

  • 部局内役職

    獣医学部 獣医学科 

    学科長  2022年04月 - 2023年03月

  • 部局内役職

    大学院獣医学研究科 獣医学専攻 

    専攻長  2022年04月 - 2023年03月