Updated on 2023/05/25

写真a

 
Nakajima Hidemitsu
 
Organization
Graduate School of Veterinary Science Department of Veterinary Science Associate Professor
School of Veterinary Science Department of Veterinary Science
Title
Associate Professor
Affiliation
Institute of Veterinary Science
Contact information
メールアドレス

Position

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - Now

  • School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - Now

Degree

  • 獣医学博士 ( Others )

Research Areas

  • Life Science / Pharmacology  / Neuropharmacology, Drug Discovery

  • Life Science / Function of nervous system  / 神経変性疾患、精神疾患、希少性脳疾患、アミロイドーシス、GAPDH、PARP

  • Life Science / Biomaterials  / Botulinum neurotoxin type A

  • Life Science / Biomedical engineering  / DDS、L-PGDS

  • Life Science / Molecular biology  / Molecular Biology, Biochemistry

Research Interests

  • 創薬

  • タンパク質凝集

  • PARP

  • Lipocalin-type prostaglandin D synthase (L-PGDS)

  • GAPDH

  • Extracellular poly(ADP-ribose)

  • Botulinum neurotoxin

  • 社会性ストレス

  • 酸化ストレス

  • 脳神経疾患

  • 脳アミロイドーシス

  • 精神疾患

Research subject summary

  • 新規GAPDH凝集阻害薬を用いた難治性疾患の創薬研究

  • GAPDHストレスカスケードを基軸としたストレス性精神疾患の発症機序および治療戦略

  • 難治性脳神経疾患へボツリヌス毒素を治療応用するための基盤研究(共同研究)

  • L-PGDSによる新規ドラッグデリバリーシステムの開発(共同研究)

  • SK channelによる消化管運動制御機構の解明

  • 核内GAPDHの細胞死誘導機構の解明

  • 新規に同定したGAPDHアミロイド様繊維の神経変性疾患における病態生理学的意義の解明

Research Career

  • Drug discovery

    GAPDH, aggregation, Inhibitor, small molecule, medicine 

  • Basic reserch for novel therapeutics of severe brain-disorders using botulinum toxins and the enzymes

    BoTox Type A, Toxin, C3 enzyme, Neurological disorders, medicine 

  • Devepopement of novel DDS using L-PGDS

    L-PGDS, DDS, solubilty of compounds, Protein science, medicine 

  • Patho-physiological roles of SK channels in PNS

    SK channel, gastrointestinal motility, Ach, Physiology, medicine 

  • Therapeutics of neurodegenerative disorders based on the our novel findings regarding GAPDH-mediated cell death cascade

    GAPDH, nulear translocation, cell death, trascription, medicine 

  • Therapeutics of neurodegenerative disorders based on the our novel findings regarding GAPDH-mediated cell death cascade

    GAPDH, Amyloid, Neurodegenerative disorders, Oxidative stress, medicine 

Professional Memberships

  • 日本獣医動物行動研究会

    2022.11 - Now   Domestic

  • Japanese Veterinary Society of Animal Behavior

    2022.11 - Now

  • 日本生化学会

    2016.04 - Now

  • 米国神経科学会(SfN)

    2013.06 - Now   Overseas

  • 米国生化学分子生物学学会(ASBMB)

    2009.06 - Now   Overseas

  • 日本神経化学会

    2005.09 - Now

  • American Society for Biochemistry and. Molecular Biology: Regular Member

    2005.09 - Now

  • 日本獣医学会

    2005.04 - Now   Domestic

  • 日本比較薬理毒性学会

    2005.04 - Now   Overseas

  • 日本薬理学会

    2005.02 - Now   Domestic

  • Society for Neuroscience: Regular Member

    1999.05 - Now

  • 日本獣医学会(評議員)

    1995.12 - Now

  • 日本薬理学会(評議員)

    1995.12 - Now

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Awards

  • 最優秀賞

    2018.02   創薬シーズ事業化コンペティション   難治性脳神経疾患の⾰新的独⾃シーズ〜GAPDH凝集阻害薬〜

  • 中村賞(学術)

    2019.05   大阪府獣医師会  

  • Best Poster Award

    2019.07   International Conference on Alzheimer’s Disease & Dementia (Dementia2019)  

  • 学長顕彰

    2020.08   大阪府立大学学長  

  • 学長顕彰

    2019.11   大阪府立大学学長  

  • 学長顕彰

    2019.08   大阪府立大学学長  

  • Best Poster Award

    Shoji M, Nakajima H et al.

    2019.07   International Conference on Alzheimer's Disease & Dementia   Oxidative stress-induced GAPDH nuclear translocation in the hippocampus causes depression behaviors by GR and BDNF downregulation in stressed mice

  • 中村賞(学術)

    中嶋秀満

    2019.05   大阪府獣医師会   GAPDHカスケードを基軸とした創薬研究

  • 大阪府知事副賞

    2018.02   大阪府知事  

  • 学長顕彰「外部資金獲得優秀者表彰」

    2013.06   大阪府立大学学長  

  • 獣医臨床研友会賞

    1996.03   大阪府立大学獣医学友会  

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Papers

  • Glyceraldehyde-3-phosphate dehydrogenase regulates activation of c-Jun N-terminal kinase under oxidative stress Reviewed

    Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Hidemitsu Nakajima

    Biochemical and Biophysical Research Communications   657   1 - 7   2023.05( ISSN:0006-291X

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.bbrc.2023.03.044

  • Glyceraldehyde-3-phosphate dehydrogenase regulates activation of c-Jun N-terminal kinase under oxidative stress Reviewed

    Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Hidemitsu Nakajima

    Biochemical and Biophysical Research Communications   657   1 - 7   2023.03

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: doi.org/10.1016/j.bbrc.2023.03.044

    Other URL: https://www.sciencedirect.com/science/article/pii/S0006291X23003297?via%3Dihub

    Repository URL: http://hdl.handle.net/10466/0002000621

  • Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. Reviewed

    Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT.

    J Cell Physiol.   2019.05

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    Kind of work:Joint Work  

  • Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. Reviewed

    Kazuhiro Nishiyama, Kimiya Aono, Yasuyuki Fujimoto, Mitsuru Kuwamura, Toshiya Okada, Hayato Tokumoto, Takeshi Izawa, Ryoichi Okano, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu-Taka Azuma

    Journal of cellular physiology   234 ( 5 )   6667 - 6678   2019.05( ISSN:0021-9541

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    International / domestic magazine:International journal  

    Organ-organ crosstalk is involved in homeostasis. Gastrointestinal symptoms are common in patients with renal failure. The aim of this study was to elucidate the relationship between gastrointestinal motility and gastrointestinal symptoms in chronic kidney disease. We performed studies in C57BL/6 mice with chronic kidney disease after 5/6 nephrectomy. Gastrointestinal motility was evaluated by assessing the ex vivo responses of ileum and distal colon strips to electrical field stimulation. Feces were collected from mice, and the composition of the gut microbiota was analyzed using 16S ribosomal RNA sequencing. Mice with chronic kidney disease after 5/6 nephrectomy showed a decreased amount of stool, and this constipation was correlated with a suppressed contraction response in ileum motility and decreased relaxation response in distal colon motility. Spermine, one of the uremic toxins, inhibited the contraction response in ileum motility, but four types of uremic toxins showed no effect on the relaxation response in distal colon motility. The 5/6 nephrectomy procedure disturbed the balance of the gut microbiota in the mice. The motility dysregulation and constipation were resolved by antibiotic treatments. The expression levels of interleukin 6, tumor necrosis factor-α, and iNOS in 5/6 nephrectomy mice were increased in the distal colon but not in the ileum. In addition, macrophage infiltration in 5/6 nephrectomy mice was increased in the distal colon but not in the ileum. We found that 5/6 nephrectomy altered gastrointestinal motility and caused constipation by changing the gut microbiota and causing colonic inflammation. These findings indicate that renal failure was remarkably associated with gastrointestinal dysregulation.

    DOI: 10.1002/jcp.27408

    PubMed

  • The Role of Interleukin-19 in Contact Hypersensitivity. Reviewed

    Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.

    Biol Pharm Bull. 雑誌   2018.03

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    Kind of work:Joint Work  

  • Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling. Reviewed

    Nishiyama K, Fujita T, Fujimoto Y, Nakajima H, Takeuchi T, Azuma YT.

    Int Immunopharmacol. 雑誌   2018.02

  • Insulin expression in cultured astrocytes and the decrease by amyloid β. Reviewed

    Takano, K., Koarashi, K., Kawabe, K., Itakura, M., Nakajima, H., Moriyama, M., and Nakamura, Y.

    Neurochem. Int. 雑誌   2017.08

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    Kind of work:Joint Work  

  • Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death. Reviewed

    Nakajima H, Itakura M, Kubo T, Kaneshige A, Harada N, Izawa T, Azuma YT, Kuwamura M, Yamaji R, Takeuchi T.

    J Biol Chem. 雑誌   2017.05

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    Kind of work:Joint Work  

  • Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo. Reviewed

    Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T.

    Biochem Biophys Res Commun. 雑誌   2017.03

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    Kind of work:Joint Work  

  • Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis. Reviewed

    Fujimoto Y, Azuma YT, Matsuo Y, Kuwamura M, Kuramoto N, Miki M, Azuma N, Teramoto M,

    Naunyn Schmiedebergs Arch Pharmacol. 雑誌   2017.03

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    Kind of work:Joint Work  

  • Na+/Ca2+ exchanger contributes to stool transport in mice with experimental diarrhea. Reviewed

    Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T.

    J Vet Med Sci. 雑誌   2017.02

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    Kind of work:Joint Work  

  • Overexpression of Na+/Ca2+ exchanger 1 display enhanced relaxation in the gastric fundus. Reviewed

    Fujimoto Y, Hayashi S, Azuma YT, Mukai K, Nishiyama K, Kita S, Morioka A, Nakajima H, Iwamoto T, Takeuchi T.

    J Pharmacol Sci.   2016.11

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    Kind of work:Joint Work  

  • Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation. Reviewed

    Kikugawa M, Tsutsuki H, Ida T, Nakajima H, Ihara H, Sakamoto T.

    Biosci Biotechnol Biochem. 雑誌   2016.11

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  • Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum. Reviewed

    Nishiyama K, Azuma YT, Morioka A, Yoshida N, Teramoto M, Tanioka K, Kita S, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T.

    Naunyn Schmiedebergs Arch Pharmacol 雑誌   2016.10

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    Kind of work:Joint Work  

  • Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death. Reviewed

    Kubo T, Nakajima H, Nakatsuji M, Itakura M, Kaneshige A, Azuma YT, Inui T, Takeuchi T.

    Nitric Oxide. 雑誌   2016.02

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    Kind of work:Joint Work  

  • Differences in time to peak carbachol-induced contractions between circular and longitudinal smooth muscles of mouse ileum. Reviewed

    Azuma YT, Samezawa N, Nishiyama K, Nakajima H, Takeuchi T.

    Naunyn Schmiedebergs Arch Pharmacol 雑誌   2016.01

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    Kind of work:Joint Work  

  • Interleukin 19 reduces inflammation in chemically induced experimental colitis. Reviewed

    Matsuo Y, Azuma YT, Kuwamura M, Kuramoto N, Nishiyama K, Yoshida N, Ikeda Y, Fujimoto Y, Nakajima H, Takeuchi T.

    Int Immunopharmacol. 雑誌   2015.12

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    Kind of work:Joint Work  

  • Glyceraldehyde-3-phosphate dehydrogenase aggregation inhibitor peptide: A potential therapeutic strategy against oxidative stress-induced cell death. Reviewed

    Itakura M, Nakajima H, Semi Y, Higashida S, Azuma YT, Takeuchi T.

    Biochem Biophys Res Commun. 雑誌   2015.11

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    Kind of work:Joint Work  

  • Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease. Reviewed

    Itakura M, Nakajima H, Kubo T, Semi Y, Kume S, Higashida S, Kaneshige A, Kuwamura M, Harada N, Kita A, Azuma YT, Yamaji R, Inui T, Takeuchi T.

    J Biol Chem. 雑誌   2015.10

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    Kind of work:Joint Work  

  • Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade. Reviewed

    Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A.

    J Biol Chem. 雑誌   2015.01

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    Kind of work:Joint Work  

  • Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. Reviewed

    Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T.

    J Biol Chem. 雑誌   2015.01

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    Kind of work:Joint Work  

  • Na/Ca(2+) exchanger 1 transgenic mice display increased relaxation in the distal colon. Reviewed

    Nishiyama K, Morioka A, Kita S, Nakajima H, Iwamoto T, Azuma YT, Takeuchi T.

    Naunyn Schmiedebergs Arch Pharmacol 雑誌   2014.11

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    Kind of work:Joint Work  

  • Amphotericin B induces glial cell line-derived neurotrophic factor in rat brain. Reviewed

    Motoyoshi-Yamashiro A, Takano K, Kawabe K, Izawa T, Nakajima H, Moriyama M, Nakamura Y.

    The Journal of Veterinary Medical Science 雑誌 The Japanese Society of Veterinary Science   in press   2014.06

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    Kind of work:Joint Work  

  • Botulinum Neurotoxin Type A Subtype 2 Confers Greater Safety than Subtype 1 in a Rat Parkinson's Disease Model. Reviewed

    Itakura M, Kohda T, Kubo T, Semi Y, Azuma YT, Nishiyama K, Nakajima H, Kozaki S, Takeuchi T.

    The Journal of Veterinary Medical Science 雑誌 The Japanese Society of Veterinary Science   in press   2014.04

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    Kind of work:Joint Work  

  • Na+/Ca2+ exchanger 1 transgenic mice display increased relaxation in the distal colon. Reviewed

    Nishiyama K, Morioka A, Kita S, Nakajima H, Iwamonoto T, Takeuchi T.

    Pharmacology 雑誌 KARGER Medical and Scietific Publisher   in press   2014.04

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    Kind of work:Joint Work  

  • Evidence that nitric oxide is a nonadrenergic-noncholinergic inhibitory neurotransmitter in the circular muscle of mouse distal colon: study on the mechanism of nitric oxide-induced relaxation. Reviewed

    Nishiyama K, Azuma YT, Shintaku K, Azuma N, Yshida N, Nakajima H, Takeuchi T.

    Pharmacology 雑誌 KARGER Medical and Scietific Publisher   in press   2014.04

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  • Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinson's disease model. Reviewed

    Itakura M, Kohda T, Kubo T, Semi Y, Azuma YT, Nakajima H, Kozaki S, Takeuchi T.

    Biochem. Biophys. Res. Commun. 雑誌 ELSEVIER SCIENCE LTD   447 ( 2 )   311 - 314   2014.03

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  • Na+/Ca2+ exchanger 1/2 double-heterozygote knockout mice display increased nitric oxide component and altered colonic motility. Reviewed

    Nishiyama K, Azuma YT, Kita S, Azuma N, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T.

    J. Pharmacol. Sci. 雑誌 The Japanese Parmacological Society   123 ( 3 )   93 - 100   2013.12

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  • Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors production. Reviewed

    Motoyoshi-Yamashiro A, Tamura M, Moriyama M, Takano K, Kawabe K, Nakajima H, Katoh-Semba R, Furuichi T, Nakamura Y.

    Neurochemistry Int. 雑誌 ELSEVIER SCIENCE LTD   63 ( 2 )   93 - 100   2013.08

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    Kind of work:Joint Work  

  • IL-19のTNBS誘発性腸疾患モデルにおける役割 Reviewed

    東 泰孝、松尾有希子、中嶋秀満、竹内正吉

    消化器と免疫 雑誌 日本消化器免疫学会   49   53 - 55   2013.04

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    Kind of work:Joint Work  

  • Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase. Reviewed

    Fukuhara A, Nakajima H, Miyamoto Y, Inoue K, Kume S, Lee YH, Noda M, Uchiyama S, Shimoto S, Mishimura S, Ohkubo T, Goto Y, Takeuchi T, Inui T.

    J.Control Release 雑誌 ELSEVIER SCIENCE LTD   159 ( 1 )   143 - 150   2012.04

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    Kind of work:Joint Work  

  • Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death. Reviewed

    Fukuhara A, Yamada M, Fujimori K, Miyamoto Y, Kusumoto T, Nakajima H, Inui T.

    Biochemical. J 雑誌 Biochemical Society   443 ( 1 )   75 - 84   2012.04

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    Kind of work:Joint Work  

  • Adenosine and ATP affect LPS-induced cytokine production in canine macrophage cell line DH82 cells. Reviewed

    Fujimoto Y, Nakatani N, Semi Y. Yoshida N, Nakajima H. Iseri T, Azuma YT, Takeuchi T.

    The Journal of Veterinary Medical Science 雑誌 The Japanese Society of Veterinary Science   74 ( 1 )   27 - 34   2012.01

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    Kind of work:Joint Work  

  • A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain. Reviewed

    Nakajima H, Kubo T, Semi Y, Itakura M, Kuwamura M, Izawa T, Azuma YT, Takeuchi.

    J. Biotechnology 雑誌 ELSEVIER SCIENCE LTD   152 ( 2 )   326 - 3233   2012.01

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    Kind of work:Joint Work  

  • IL-19 as a potential therapeutic in autoimmune and inflammatory diseases. Reviewed

    Azuma YT, Nakajima H, Takeuchi.

    Curr. Pharm. Des. 雑誌 BenthamScience LTD   17 ( 34 )   3776 - 3780   2011.11

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    Kind of work:Joint Work  

  • Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery. Reviewed

    Azuma YT, Nishiyama K, Morioka A, Nakajima H, Takeuchi T.

    Pharmacology 雑誌 KARGER Medical and Scietific Publisher   88 ( 1-2 )   65 - 71   2011.08

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  • Interleukin-19 is a Negative Regulator of Innate Immunity and Critical for Colonic Protection Reviewed

    Azuma YT, Matsuo Y, Nakajima H, Yacopouls DG, Valenzuela DM, Murphy AJ, Karow M, Takeuchi T.

    J. Pharmacol. Sci. 雑誌 The Japanese Parmacological Society   113 ( 2 )   105 - 111   2011.01

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  • Nitric oxide and carbon monoxide act as inhibitory neurotransmitters in the longitudinal muscle of C57BL/6J mouse distal colon. Reviewed

    Hidaka A, Azuma YT, Nakajima H, Takeuchi T.

    J. Pharmacol. Sci. 雑誌 The Japanese Parmacological Society   112 ( 2 )   231 - 241   2010.10

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  • IL-19遺伝子欠損マウスにおけるDSS誘発性大腸炎の増悪 Reviewed

    東 泰孝、松尾有希子、桑村 充、中嶋秀満、竹内正吉

    消化器免疫 雑誌 日本消化器免疫学会   46   131 - 134   2010.07

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  • PPARa contributes to colonic protection in mice with DSS-induced colitis Reviewed

    Azuma YT, Nishiyama K, Matsuo Y, Kuwamura M, Morioka A, Nakajima H, Takeuchi T.

    Int. Immunopharmacol. 雑誌 ELSEVIER SCIENCE LTD   10 ( 10 )   1261 - 1267   2010.07

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    Kind of work:Joint Work  

  • 解糖系酵素glyceraldehyde-3-phosphate dehydrogenase (GAPDH) の多機能性と酸化ストレス性細胞死における役割 Reviewed

    中嶋秀満、東 泰孝、竹内正吉

    放射線生物研究 雑誌 日本放射線生物学会   45 ( 2 )   127 - 139   2010.07

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  • Interleukin-19 protects mice from innate-mediated colonic inflammation. Reviewed

    Azuma YT, Matsuo Y, Kuwamura M, Yacopouls DG, Valenzuela DM, Murphy AJ, Nakajima H, Takeuchi T.

    Inflammatory Bowel Diseases 雑誌 WILEY-LISS, DIV JOHN WILEY & SONS INC   16 ( 6 )   1017 - 1028   2010.07

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    Kind of work:Joint Work  

  • An aggregate-prone mutant of human glyceraldehyde-3-phosphate dehydrogenase augments oxidative stress-induced cell death in SH-SY5Y cells. Reviewed

    Nakajima H, Amano W, Fukuhara A, Kubo T, Misaki S, Azuma YT, Inui T, Takeuchi T.

    Biochem. Biophys. Res. Commun. 雑誌 ELSEVIER SCIENCE LTD   390 ( 3 )   1066 - 1071   2009.12

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    Kind of work:Joint Work  

  • GAPDH aggregate formation participates in oxidative stress-induced cell death (in press) Reviewed

    Hidemitsu Nakajima, Wataru Amano, Takeya Kubo, Ayano Fukuhara, Hideshi Ihara, Yasu-Taka Azuma, Hisao Tajima, Takashi Inui, Akira Sawa, and Tadayoshi Takeuchi1

    J. Biol. Chem. 雑誌 The American Society for Biochemistry and Molecular Biology (ASBMB)   284 ( 49 )   34331 - 34341   2009.10

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  • PACAP欠損マウスにおけるDSS誘発性腸炎の増悪. Reviewed

    東 泰孝、新谷紀人、桑村 充、中嶋秀満、橋本 均、馬場明道、竹内正吉

    消化器と免疫 著書 日本消化器免疫学会   45 ( 1 )   134 - 138   2009.01

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  • The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse. Reviewed

    Tadayoshi Takeuchi, Noriyuki Yamashiro, Tetsuya Kawasaki, Hidemitsu Nakajima, Yasu-Taka Azuma, Minoru Matsui

    Neuroscience 雑誌 PERGAMON-ELSEVIER SCIENCE LTD   156 ( 2 )   381 - 389   2008.10

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  • Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus. Reviewed

    Kiyomi Hagi, Yasu-Taka Azuma, Hidemitsu Nakajima, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba and Tadayoshi Takeuchi

    Eur. J. Pharmacol. 雑誌 ELSEVIER SCIENCE LTD   590 ( 6 )   80 - 86   2008.08

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  • PACAP provides colonic protection against dextran sodium sulfate induced colitis. Reviewed

    Yasu-Taka Azuma, Kiyomi Hagi, Norihito Shintani, Mitsuru Kuwamura, Hidemitsu Nakajima, Hitoshi Hashimoto, Akemichi Baba and Tadayoshi Takeuchi

    J. Cell. Physiol. 雑誌 WILEY-LISS, DIV JOHN WILEY & SONS INC   216 ( 1 )   111 - 119   2008.07

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  • Functional interaction between SK2 channel and the nicotinic acetylcholine receptor in enteric neurons of the guinea pig ileum Reviewed

    Hidemitsu Nakajima, Hiroto Gotoh, Akikazu Fujita, Yasu-Taka Azuma, and Tadayoshi Takeuchi

    J. Neurochem 雑誌 BLACKWELL PUBLISHING   103 ( 6 )   2428 - 2438   2007.12

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  • Distribution and immunohistochemical localization of GDNF protein in selected neural and non-neural tissues of rats during development and its changes with a unilateral 6-hydroxydopamine lesion. Reviewed

    Ritsuko Katoh-Semba, Masako Tsuzuki, Noriko Miyazaki, Akiko Yoshida, Hidemitsu Nakajima, Chiaki Nakagawa, Satoko Kitajima, and Motoko Matsuda

    Neurosci. Res. 雑誌 ELSEVIER SCIENCE LTD   59 ( 3 )   277 - 287   2007.11

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    Kind of work:Joint Work  

  • The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death. Reviewed

    Hidemitsu Nakajima, Wataru Amana, Akikazu Fujita, Ayano Fukuhara, Yasu-Taka Azuma, Fumiaki Hata, Takashi Inui, and Tadayoshi Takeuchi

    J. Biol. Chem. 雑誌 The American Society for Biochemistry and Molecular Biology (ASBMB)   282 ( 36 )   26562 - 74   2007.09

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    Kind of work:Joint Work  

  • A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon Reviewed

    Tadayoshi Takeuchi, Hidemitsu Nakajima, Fumiaki Hata and Yasu-Taka Azuma

    Pflugers Arch. 雑誌 SPRINGER   454 ( 4 )   565 - 574   2007.07

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    Kind of work:Joint Work  

  • Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives. Reviewed

    Kumiko Ando, Yukiko Akai, Jun-ichi Kunitomo, Takehiko Yokomizo, Hidemitsu Nakajima, Tadayoshi Takeuchi, Masayuki Yamashita, Shunsaku Ohta, Takahiro Ohishi and Yoshitaka Ohishi

    Org. Biomol. Chem. 雑誌 ROYAL SOC CHEMISTRY   5 ( 4 )   655 - 663   2007.02

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    Kind of work:Joint Work  

  • M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: findings obtained using muscarinic receptor knockout mouse Reviewed

    Tadayoshi Takeuchi, Keisuke Tanaka, Hidemitsu Nakajima, Minoru Matsui, and Yasu-Taka Azuma

    Am. J. Physiol. Gastrointest Liver Physiol, 雑誌 The American Physiological Society   292 ( 1 )   154 - 164   2007.01

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    Kind of work:Joint Work  

  • Orexin A affects ascending contration depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum Reviewed

    Yuji Satoh, Yutaka Okishio, Yasu-Taka Azuma, Hidemitsu Nakajima, Fumiaki Hata, and Tadayoshi Takeuchi

    Neuropharmacology 雑誌 ELSEVIER SCIENCE LTD   51 ( 3 )   466 - 473   2006.09

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    Kind of work:Joint Work  

  • Inhibitory effects of alendronate on cholinergic responses in rat lower esophageal sphincter. Reviewed

    Tadayoshi Takeuchi, Aki Nakamura, Hidemitsu Nakajima, Yasu-Taka Azuma, and Fumiaki Hata

    Eur. J. Pharmacol. 雑誌 ELSEVIER SCIENCE LTD   537 ( 1-3 )   155 - 159   2006.05

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    Kind of work:Joint Work  

  • Involvement of M(2) muscarinic receptors in relaxant response of circular muscle of mouse gastric antrum Reviewed

    Tadayoshi Takeuchi, Makiko Toyoshima, Kazunori Mukai, Kiyomi Hagi, Minoru Matsui, Hidemitsu Nakajima, Yasu-Taka Azuma, and Fumiaki Hata

    Neurogastroenterol. Motil. 雑誌 ELSEVIER SCIENCE LTD   18 ( 3 )   226 - 233   2006.03

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    Kind of work:Joint Work  

  • A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats Reviewed

    Hidemitsu Nakajima, Nobukazu Kakui, Kunihiro Ohkuma, Midori Ishikawa, and Toshifumi Hasegawa

    J. Pharmacol. Exp. Ther. 雑誌 The American Society for Pahrmacology and Experimental Pharmaceutics (ASPET)   312 ( 2 )   472 - 481   2005.02

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    Kind of work:Joint Work  

  • Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells. Reviewed

    Hidemitsu Nakajima, Hiroshi Nagaso, Nobukazu Kakui, Midori Ishikawa, Toyokazu Hiranuma, Shigeru Hoshiko

    J. Biol. Chem. 雑誌 The American Society for Biochemistry and Molecular Biology (ASBMB)   279 ( 41 )   42774 - 86   2004.10

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    Kind of work:Joint Work  

  • Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide. Reviewed

    Toshiaki Ishii, Osamu Sunami, Hidemitsu Nakajima, Hideaki Nishio, Tadayoshi Takeuchi, and Fumiaki Hata

    Biochem. Pharmacol. 雑誌 ELSEVIER SCIENCE LTD   58 ( 1 )   133 - 143   1999.07

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    Kind of work:Joint Work  

  • Cyclic GMP and relaxation of rat colonic smooth muscle Reviewed

    Tadayoshi T, Nakajima H, Kichi M, Sumiyoshi M, Hata F.

    J. Smooth Muscle Res. 雑誌 日本平滑筋学会機関誌   36 ( 6 )   465 - 467   1995.09

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    Kind of work:Joint Work  

  • Involvement of heterotrimeric GTP-binding protein and rho protein, but not protein kinase C, in agonist-induced Ca2+ sensitization of skinned muscle of guinea pig vas deferens. Reviewed

    Akikazu Fujita, Tadayoshi Takeuchi, Hidemitsu Nakajima, Hideaki Hishio, and Fumiaki Hata

    J. Pharmacol. Exp. Ther. 雑誌 The American Society for Pahrmacology and Experimental Pharmaceutics (ASPET)   274 ( 1 )   555 - 561   1995.01

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    Kind of work:Joint Work  

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Books and Other Publications

  • 薬理学・毒性学実験 第4版

    中嶋秀満( Role: Contributor ,  動物の麻酔・動物の安楽死)

    日本獣医薬理学・毒性学会  2023.03 

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    Total pages:225   Responsible for pages:6-8   Book type:Textbook, survey, introduction

  • Botulinum Toxin

    Nikolay Serdev, Michel R. Popoff, Giovanna Fico, Hidemitsu Nakajima, Ronald Feiner, Hsien-Li Peter Peng, Diana Mostafa, Daniel Mondlak Algazi, Tariq F. Al-Shaiji( Role: Joint author)

    InTechOpen  2018.08 

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    Responsible for pages:47-63  

    DOI: 10.5772/intechopen.8

  • 獣医薬理学 第3版

    日本比較薬理学・毒性学会( Role: Joint author)

    文永堂出版株式会社  2012.04 

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    Responsible for pages:13-14,58,88-91,115-116  

  • 薬理学・毒性学実験 第3版

    日本比較薬理学・毒性学会( Role: Joint author)

    文永堂出版株式会社  2008.04 

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    Responsible for pages:13-14,58,88-91,115-116  

MISC

  • 活性イオウ分子を基軸とした大豆たん白質および関連成分の基礎的研究—Fundamental Research on Soy Protein and Related Components Based on Reactive Sulfur Species—第24回研究報告会記録

    居原 秀, 赤池 孝章, 中嶋 秀満, 笠松 真吾

    大豆たん白質研究 / 不二たん白質研究振興財団 [編]   24 ( 42 )   1 - 5   2022.07( ISSN:1344-4050

  • アルツハイマー病およびてんかんモデルマウスにおける8-nitro-cGMP産生と神経活動への影響

    居原秀, 岸本祐典, 笠松真吾, 中嶋秀満, 赤池孝章

    日本NO学会学術集会プログラム抄録集   19th   2019

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  • NASHモデルを用いたIL-19が病態形成に及ぼす影響

    牛飼裕美, 藤本泰之, 井澤武史, 桑村充, 中嶋秀満, 竹内正吉, 東泰孝

    日本獣医学会学術集会講演要旨集   162nd   2019( ISSN:1347-8621

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Presentations

  • 多機能性酵素GAPDHのレドックス制御と脳神経疾患-GAPDHカスケードを標的とした創薬研究と治療戦略- Invited

    中嶋秀満

    大阪大学 蛋白質研究所 高次脳機能学セミナー  2023.03  大阪大学 蛋白質研究所 高次脳機能 疋田貴俊教授

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    Presentation type:Oral presentation (invited, special)  

    Venue:大阪大学  

  • 多機能性酵素GAPDHのレドックス制御と脳神経疾患-GAPDHカスケードを標的とした創薬研究と治療戦略- Invited

    中嶋秀満

    大阪大学 蛋白質研究所 高次脳機能学セミナー  2023.03 

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    Presentation type:Oral presentation (invited, special)  

  • NASHモデルを用いたIL-19が病態形成に及ぼす影響

    牛飼 裕美, 藤本 泰之, 井澤 武史, 桑村 充, 中嶋 秀満, 竹内 正吉, 東 泰孝

    日本獣医学会学術集会講演要旨集  2019.08  (公社)日本獣医学会

  • Oxidative stress-induced GAPDH nuclear translocation in the hippocampus causes depression behaviors by GR and BDNF downregulation in stressed mice. (Best Poster Award) Invited

    Shoji M, and Nakajima H. et al.

    Internatinal Conference on Alzheimer’s Disease & Dementia2019  2019.07 

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    Presentation type:Poster presentation  

  • 腎機能障害は腸内細菌叢を乱し、腸の運動性を変化させる(Renal impairment disturbs the intestinal microbiota and alters intestinal motility)

    Nishiyama Kazuhiro, Azuma Yasu-taka, Nakajima Hidemitsu, Takeuchi Tadayoshi

    The Journal of Physiological Sciences  2019.06  (一社)日本生理学会

Industrial Property Rights

  • Non-peptidic GAPDH aggregation inhibitor

    Hidemitsu Nakajima

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    property_type:Patent 

    Application no:US15/574651 

    Announcement no:US15/574651 

    Publication no:US10137097B2 

    Patent/Registration no:US15/574651 

  • 非ペプチド性GAPDH凝集阻害剤

    中嶋秀満

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    property_type:Patent 

    Application no:JP2017523665 

    Announcement no:JP2017523665 

    Publication no:JP2017523665 

    Patent/Registration no:JP2017523665 

Outline of collaborative research (seeds)

  • GAPDH凝集阻害薬に関する創薬研究

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    Request for collaborative research:The private sector, such as other institutions

    Type of research exchange:Technical consultation, Contract research, Joint research, Lecture

    Core knowledge, technology, information etc:新規低分子化合物

    Expected ripple effect:難治性疾患の克服

  • PARP-1に関する研究

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    前職ではPARP-1阻害剤の創薬研究に従事し、一連のアッセイ系をマスターしている。また主な研究テーマ情報にあるように、現職においても引き続きPARP-1との相互作用蛋白質、およびその合成物質であるpoly ADP-riboseの標的蛋白質の探索を実施中である。従って、新規PARP-1阻害剤のスクリーニング、PARP-1阻害剤のモデル動物を用いた有効性評価、加えてpoly ADP-ribose合成法や精製法の技術が提供可能である。

  • GAPDHに関する研究

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    主な研究テーマ情報にあるように、研究者は各種GAPDHの組み換え蛋白質、特異的抗体、過剰発現細胞株のラインナップが整備されており、また、GAPDH研究のパイオニアであるジョンズホプキンス大学との共同研究も推進しているのでGAPDH関連の最新情報の提供も可能である。また、本学では主として神経系に焦点を絞って研究を進めているが、GAPDHが多機能蛋白質であることや他疾患にも関与するという報告などからも、神経系以外での共同研究も可能であある。

Joint research

  • 活性イオウ分子を基軸とした大豆たん白質および関連成分の基礎的研究

    公益財団法人不二たん白質研究振興財団  公益財団法人不二たん白質研究振興財団 令和2年度 研究助成課題  2022.04

Contract research

  • 細胞の液-液相分離現象にフォー カスした新規治療薬の開発

    AMED橋渡し研究プログラム異分野融合型研究開発推進支援事業  AMED橋渡し研究プログラム異分野融合型研究開発推進支援事業  2022.09

Charge of on-campus class subject

  • 小動物基礎臨床実習

    2022   Intensive lecture   Undergraduate

  • 動物行動解析学

    2022   Intensive lecture   Undergraduate

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 発生学

    2022   Weekly class   Undergraduate

  • 基礎動物生理学

    2022   Weekly class   Undergraduate

  • 獣医体験演習

    2022   Weekly class   Undergraduate

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 獣医科学特別演習1

    2022   Intensive lecture   Graduate school

  • 国際・国内インターンシップ

    2022   Intensive lecture   Graduate school

  • 生物学A獣医

    2022   Intensive lecture   Graduate school

  • Biology A

    2021    

  • Animal Physiology on Basic

    2021    

  • Veterinary Embryology

    2021    

  • Veterinary Embryology

    2021    

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Charge of off-campus class subject

  • 生体高分子機能学特論

    2022.06

  • 動物行動解析学

    2016.04
    -
    Now
    Institution:Osaka Prefecture University

  • 実験動物学

    2010.04
    -
    Now
    Institution:Osaka Prefecture University

  • 神経内分泌学

    2010.04
    -
    Now
    Institution:Osaka Prefecture University

  • 獣医薬理学

    2010.04
    -
    Now
    Institution:Osaka Prefecture University

Faculty development activities

  • 創薬科学研究所の運営・シンポジウムの開催  2022

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    第6回創薬シンポジウムの開催準備・運営を、創薬科学研究所員として実施した。また、次年度開催の第7回シンポジウムの講演者(3名)として立案・企画・事前を打合せを実施中。

Number of instructed thesis, researches

  • 2019

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

  • 2018

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

    [Number of instructed the Master's Program] (letter term):1

    [Number of master's thesis reviews] (chief):

  • 2017

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

    [Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (chief):

    [Number of doctoral thesis reviews] (vice-chief):1

  • 2016

    Number of instructed the graduation thesis:Number of graduation thesis reviews:3

    [Number of instructed the Master's Program] (letter term):2

  • 2015

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):2

  • 2014

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (chief):

  • 2013

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (chief):

  • 2012

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (chief):

  • 2011

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):2

    [Number of master's thesis reviews] (vice-chief):2

  • 2010

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):1

    [Number of master's thesis reviews] (chief):

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Original item・Special report (Education Activity)

  • 2022

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    Original item:担当講義・実習に関する学生の理解度・満足度・時間外学習の向上に向けた個別アンケートの実施

    Special report:「授業外時間学習時間の平均値向上」をかかげ、講義前に予習用教材アップロードとアナウンスメントを実施した結果、てぃら・みすデータでは動物行動解析学1.71→2.82および基礎動物生理学2.22→2.67と改善傾向がみられたものの、部局内平均(各2.73、2.46)に到達したに過ぎず、次年度への課題となった。また、個別に「講義理解度」(Q1-6)および「講義満足度」(Q1-8)を集計したところ、動物行動解析学:理解度4.83(4.46)満足度5.00(4.92)(回答率57%)、基礎動物生理学:理解度5.29(4.58)満足度5.67(5.03)(回答率75%)(数字後の括弧内は部局内平均値)という結果となり、平均を上回る結果を得た。

Social Activities

  • 日本獣医学会 評議員

    日本獣医学会  2010.04 - Now

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    SDGs:

    Type:Other

  • 日本薬理学会 評議員

    日本薬理学会  2010.04 - Now

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    SDGs:

    Type:Other

Media Coverage

  • AMED『橋渡し研究プログラム異分野融合型研究開発推進支援事業』に2件の研究課題が採択 Internet

    大阪公立大学  大阪公立大学 学術研究推進本部 URAセンター  大阪公立大学 最新の研究成果  2022.09

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    SDGs:

Academic Activities

  • Current Medicinal Chemistry, Histology and Histopathology, Current Molecular Medicine, Global Journal of Medical and Clinical Case Reports, Anti-Cancer Agents in Medicinal Chemistry, Current Drug Metabolism, Current Protein & Peptide Science, Current Alzheimer Research, Journal of Biology and Medicine,

    Role(s): Peer review

    2022.04 - 2023.03

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    Type:Peer review 

Other

  • 研究職歴

    2010.04 - Now

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    大阪府立大学 生命環境科学研究科 獣医学専攻 統合バイオ機能学講座(応用薬理学) 准教授