Updated on 2023/05/25
Graduate School of Veterinary Science Department of Veterinary Science
Associate Professor 2022.04 - Now
School of Veterinary Science Department of Veterinary Science
Associate Professor 2022.04 - Now
獣医学博士 （ Others ）
Life Science / Pharmacology / Neuropharmacology, Drug Discovery
Life Science / Function of nervous system / 神経変性疾患、精神疾患、希少性脳疾患、アミロイドーシス、GAPDH、PARP
Life Science / Biomaterials / Botulinum neurotoxin type A
Life Science / Biomedical engineering / DDS、L-PGDS
Life Science / Molecular biology / Molecular Biology, Biochemistry
酸化ストレス
脳神経疾患
脳アミロイドーシス
精神疾患
社会性ストレス
創薬
タンパク質凝集
PARP
Lipocalin-type prostaglandin D synthase (L-PGDS)
GAPDH
Extracellular poly(ADP-ribose)
Botulinum neurotoxin
新規GAPDH凝集阻害薬を用いた難治性疾患の創薬研究
GAPDHストレスカスケードを基軸としたストレス性精神疾患の発症機序および治療戦略
難治性脳神経疾患へボツリヌス毒素を治療応用するための基盤研究（共同研究）
L-PGDSによる新規ドラッグデリバリーシステムの開発（共同研究）
SK channelによる消化管運動制御機構の解明
核内GAPDHの細胞死誘導機構の解明
新規に同定したGAPDHアミロイド様繊維の神経変性疾患における病態生理学的意義の解明
Drug discovery
GAPDH, aggregation, Inhibitor, small molecule, medicine
Basic reserch for novel therapeutics of severe brain-disorders using botulinum toxins and the enzymes
BoTox Type A, Toxin, C3 enzyme, Neurological disorders, medicine
Devepopement of novel DDS using L-PGDS
L-PGDS, DDS, solubilty of compounds, Protein science, medicine
Patho-physiological roles of SK channels in PNS
SK channel, gastrointestinal motility, Ach, Physiology, medicine
Therapeutics of neurodegenerative disorders based on the our novel findings regarding GAPDH-mediated cell death cascade
GAPDH, nulear translocation, cell death, trascription, medicine
Therapeutics of neurodegenerative disorders based on the our novel findings regarding GAPDH-mediated cell death cascade
GAPDH, Amyloid, Neurodegenerative disorders, Oxidative stress, medicine
日本獣医動物行動研究会
2022.11 - Now Domestic
Japanese Veterinary Society of Animal Behavior
2022.11 - Now
日本生化学会
2016.04 - Now
米国神経科学会（SfN）
2013.06 - Now Overseas
米国生化学分子生物学学会（ASBMB）
2009.06 - Now Overseas
日本神経化学会
2005.09 - Now
American Society for Biochemistry and. Molecular Biology: Regular Member
2005.09 - Now
日本獣医学会
2005.04 - Now Domestic
日本比較薬理毒性学会
2005.04 - Now Overseas
日本薬理学会
2005.02 - Now Domestic
Society for Neuroscience: Regular Member
1999.05 - Now
日本獣医学会（評議員）
1995.12 - Now
日本薬理学会（評議員）
1995.12 - Now
2018.02 創薬シーズ事業化コンペティション 難治性脳神経疾患の⾰新的独⾃シーズ〜GAPDH凝集阻害薬〜
中村賞（学術）
2019.05 大阪府獣医師会
Best Poster Award
2019.07 International Conference on Alzheimer’s Disease & Dementia (Dementia2019)
学長顕彰
2020.08 大阪府立大学学長
学長顕彰
2019.11 大阪府立大学学長
学長顕彰
2019.08 大阪府立大学学長
Best Poster Award
Shoji M, Nakajima H et al.
2019.07 International Conference on Alzheimer's Disease & Dementia Oxidative stress-induced GAPDH nuclear translocation in the hippocampus causes depression behaviors by GR and BDNF downregulation in stressed mice
中村賞（学術）
中嶋秀満
2019.05 大阪府獣医師会 GAPDHカスケードを基軸とした創薬研究
大阪府知事副賞
2018.02 大阪府知事
学長顕彰「外部資金獲得優秀者表彰」
2013.06 大阪府立大学学長
獣医臨床研友会賞
1996.03 大阪府立大学獣医学友会
Glyceraldehyde-3-phosphate dehydrogenase regulates activation of c-Jun N-terminal kinase under oxidative stress Reviewed
Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Hidemitsu Nakajima
Biochemical and Biophysical Research Communications 657 1 - 7 2023.05（ ISSN:0006-291X ）
Glyceraldehyde-3-phosphate dehydrogenase regulates activation of c-Jun N-terminal kinase under oxidative stress Reviewed
Masanori Itakura, Takeya Kubo, Akihiro Kaneshige, Hidemitsu Nakajima
Biochemical and Biophysical Research Communications 657 1 - 7 2023.03
Chronic kidney disease after 5/6 nephrectomy disturbs the intestinal microbiota and alters intestinal motility. Reviewed
Nishiyama K, Aono K, Fujimoto Y, Kuwamura M, Okada T, Tokumoto H, Izawa T, Okano R, Nakajima H, Takeuchi T, Azuma YT.
J Cell Physiol. 2019.05
Kazuhiro Nishiyama, Kimiya Aono, Yasuyuki Fujimoto, Mitsuru Kuwamura, Toshiya Okada, Hayato Tokumoto, Takeshi Izawa, Ryoichi Okano, Hidemitsu Nakajima, Tadayoshi Takeuchi, Yasu-Taka Azuma
Journal of cellular physiology 234 ( 5 ) 6667 - 6678 2019.05（ ISSN:0021-9541 ）
The Role of Interleukin-19 in Contact Hypersensitivity. Reviewed
Fujimoto Y, Fujita T, Kuramoto N, Kuwamura M, Izawa T, Nishiyama K, Yoshida N, Nakajima H, Takeuchi T, Azuma YT.
Biol Pharm Bull. 雑誌 2018.03
Fatty acid transport protein 1 enhances the macrophage inflammatory response by coupling with ceramide and c-Jun N-terminal kinase signaling. Reviewed
Nishiyama K, Fujita T, Fujimoto Y, Nakajima H, Takeuchi T, Azuma YT.
Int Immunopharmacol. 雑誌 2018.02
Insulin expression in cultured astrocytes and the decrease by amyloid β. Reviewed
Takano, K., Koarashi, K., Kawabe, K., Itakura, M., Nakajima, H., Moriyama, M., and Nakamura, Y.
Neurochem. Int. 雑誌 2017.08
Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death. Reviewed
Nakajima H, Itakura M, Kubo T, Kaneshige A, Harada N, Izawa T, Azuma YT, Kuwamura M, Yamaji R, Takeuchi T.
J Biol Chem. 雑誌 2017.05
Extracellular poly(ADP-ribose) is a neurotrophic signal that upregulates glial cell line-derived neurotrophic factor (GDNF) levels in vitro and in vivo. Reviewed
Nakajima H, Itakura M, Sato K, Nakamura S, Azuma YT, Takeuchi T.
Biochem Biophys Res Commun. 雑誌 2017.03
Interleukin-19 contributes as a protective factor in experimental Th2-mediated colitis. Reviewed
Fujimoto Y, Azuma YT, Matsuo Y, Kuwamura M, Kuramoto N, Miki M, Azuma N, Teramoto M,
Naunyn Schmiedebergs Arch Pharmacol. 雑誌 2017.03
Na+/Ca2+ exchanger contributes to stool transport in mice with experimental diarrhea. Reviewed
Nishiyama K, Tanioka K, Azuma YT, Hayashi S, Fujimoto Y, Yoshida N, Kita S, Suzuki S, Nakajima H, Iwamoto T, Takeuchi T.
J Vet Med Sci. 雑誌 2017.02
Overexpression of Na+/Ca2+ exchanger 1 display enhanced relaxation in the gastric fundus. Reviewed
Fujimoto Y, Hayashi S, Azuma YT, Mukai K, Nishiyama K, Kita S, Morioka A, Nakajima H, Iwamoto T, Takeuchi T.
J Pharmacol Sci. 2016.11
Water-soluble ferulic acid derivatives improve amyloid-β-induced neuronal cell death and dysmnesia through inhibition of amyloid-β aggregation. Reviewed
Kikugawa M, Tsutsuki H, Ida T, Nakajima H, Ihara H, Sakamoto T.
Biosci Biotechnol Biochem. 雑誌 2016.11
Roles of Na(+)/Ca(2+) exchanger isoforms NCX1 and NCX2 in motility in mouse ileum. Reviewed
Nishiyama K, Azuma YT, Morioka A, Yoshida N, Teramoto M, Tanioka K, Kita S, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T.
Naunyn Schmiedebergs Arch Pharmacol 雑誌 2016.10
Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death. Reviewed
Kubo T, Nakajima H, Nakatsuji M, Itakura M, Kaneshige A, Azuma YT, Inui T, Takeuchi T.
Nitric Oxide. 雑誌 2016.02
Differences in time to peak carbachol-induced contractions between circular and longitudinal smooth muscles of mouse ileum. Reviewed
Azuma YT, Samezawa N, Nishiyama K, Nakajima H, Takeuchi T.
Naunyn Schmiedebergs Arch Pharmacol 雑誌 2016.01
Interleukin 19 reduces inflammation in chemically induced experimental colitis. Reviewed
Matsuo Y, Azuma YT, Kuwamura M, Kuramoto N, Nishiyama K, Yoshida N, Ikeda Y, Fujimoto Y, Nakajima H, Takeuchi T.
Int Immunopharmacol. 雑誌 2015.12
Glyceraldehyde-3-phosphate dehydrogenase aggregation inhibitor peptide: A potential therapeutic strategy against oxidative stress-induced cell death. Reviewed
Itakura M, Nakajima H, Semi Y, Higashida S, Azuma YT, Takeuchi T.
Biochem Biophys Res Commun. 雑誌 2015.11
Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease. Reviewed
Itakura M, Nakajima H, Kubo T, Semi Y, Kume S, Higashida S, Kaneshige A, Kuwamura M, Harada N, Kita A, Azuma YT, Yamaji R, Inui T, Takeuchi T.
J Biol Chem. 雑誌 2015.10
Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade. Reviewed
Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A.
J Biol Chem. 雑誌 2015.01
Nuclear-translocated Glyceraldehyde-3-phosphate Dehydrogenase Promotes Poly(ADP-ribose) Polymerase-1 Activation during Oxidative/Nitrosative Stress in Stroke. Reviewed
Nakajima H, Kubo T, Ihara H, Hikida T, Danjo T, Nakatsuji M, Shahani N, Itakura M, Ono Y, Azuma YT, Inui T, Kamiya A, Sawa A, Takeuchi T.
J Biol Chem. 雑誌 2015.01
Na/Ca(2+) exchanger 1 transgenic mice display increased relaxation in the distal colon. Reviewed
Nishiyama K, Morioka A, Kita S, Nakajima H, Iwamoto T, Azuma YT, Takeuchi T.
Naunyn Schmiedebergs Arch Pharmacol 雑誌 2014.11
Amphotericin B induces glial cell line-derived neurotrophic factor in rat brain. Reviewed
Motoyoshi-Yamashiro A, Takano K, Kawabe K, Izawa T, Nakajima H, Moriyama M, Nakamura Y.
The Journal of Veterinary Medical Science 雑誌 The Japanese Society of Veterinary Science in press 2014.06
Botulinum Neurotoxin Type A Subtype 2 Confers Greater Safety than Subtype 1 in a Rat Parkinson's Disease Model. Reviewed
Itakura M, Kohda T, Kubo T, Semi Y, Azuma YT, Nishiyama K, Nakajima H, Kozaki S, Takeuchi T.
The Journal of Veterinary Medical Science 雑誌 The Japanese Society of Veterinary Science in press 2014.04
Na+/Ca2+ exchanger 1 transgenic mice display increased relaxation in the distal colon. Reviewed
Nishiyama K, Morioka A, Kita S, Nakajima H, Iwamonoto T, Takeuchi T.
Pharmacology 雑誌 KARGER Medical and Scietific Publisher in press 2014.04
Evidence that nitric oxide is a nonadrenergic-noncholinergic inhibitory neurotransmitter in the circular muscle of mouse distal colon: study on the mechanism of nitric oxide-induced relaxation. Reviewed
Nishiyama K, Azuma YT, Shintaku K, Azuma N, Yshida N, Nakajima H, Takeuchi T.
Pharmacology 雑誌 KARGER Medical and Scietific Publisher in press 2014.04
Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinson's disease model. Reviewed
Itakura M, Kohda T, Kubo T, Semi Y, Azuma YT, Nakajima H, Kozaki S, Takeuchi T.
Biochem. Biophys. Res. Commun. 雑誌 ELSEVIER SCIENCE LTD 447 ( 2 ) 311 - 314 2014.03
Na+/Ca2+ exchanger 1/2 double-heterozygote knockout mice display increased nitric oxide component and altered colonic motility. Reviewed
Nishiyama K, Azuma YT, Kita S, Azuma N, Hayashi S, Nakajima H, Iwamoto T, Takeuchi T.
J. Pharmacol. Sci. 雑誌 The Japanese Parmacological Society 123 ( 3 ) 93 - 100 2013.12
Activation of cultured astrocytes by amphotericin B: Stimulation of NO and cytokines production and changes in neurotrophic factors production. Reviewed
Motoyoshi-Yamashiro A, Tamura M, Moriyama M, Takano K, Kawabe K, Nakajima H, Katoh-Semba R, Furuichi T, Nakamura Y.
Neurochemistry Int. 雑誌 ELSEVIER SCIENCE LTD 63 ( 2 ) 93 - 100 2013.08
IL-19のTNBS誘発性腸疾患モデルにおける役割 Reviewed
東 泰孝、松尾有希子、中嶋秀満、竹内正吉
消化器と免疫 雑誌 日本消化器免疫学会 49 53 - 55 2013.04
Lipocalin-type prostaglandin D synthase protects against oxidative stress-induced neuronal cell death. Reviewed
Fukuhara A, Yamada M, Fujimori K, Miyamoto Y, Kusumoto T, Nakajima H, Inui T.
Biochemical. J 雑誌 Biochemical Society 443 ( 1 ) 75 - 84 2012.04
Drug delivery system for poorly water-soluble compounds using lipocalin-type prostaglandin D synthase. Reviewed
Fukuhara A, Nakajima H, Miyamoto Y, Inoue K, Kume S, Lee YH, Noda M, Uchiyama S, Shimoto S, Mishimura S, Ohkubo T, Goto Y, Takeuchi T, Inui T.
J.Control Release 雑誌 ELSEVIER SCIENCE LTD 159 ( 1 ) 143 - 150 2012.04
A rapid, targeted, neuron-selective, in vivo knockdown following a single intracerebroventricular injection of a novel chemically modified siRNA in the adult rat brain. Reviewed
Nakajima H, Kubo T, Semi Y, Itakura M, Kuwamura M, Izawa T, Azuma YT, Takeuchi.
J. Biotechnology 雑誌 ELSEVIER SCIENCE LTD 152 ( 2 ) 326 - 3233 2012.01
Adenosine and ATP affect LPS-induced cytokine production in canine macrophage cell line DH82 cells. Reviewed
Fujimoto Y, Nakatani N, Semi Y. Yoshida N, Nakajima H. Iseri T, Azuma YT, Takeuchi T.
The Journal of Veterinary Medical Science 雑誌 The Japanese Society of Veterinary Science 74 ( 1 ) 27 - 34 2012.01
IL-19 as a potential therapeutic in autoimmune and inflammatory diseases. Reviewed
Azuma YT, Nakajima H, Takeuchi.
Curr. Pharm. Des. 雑誌 BenthamScience LTD 17 ( 34 ) 3776 - 3780 2011.11
Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery. Reviewed
Azuma YT, Nishiyama K, Morioka A, Nakajima H, Takeuchi T.
Pharmacology 雑誌 KARGER Medical and Scietific Publisher 88 ( 1-2 ) 65 - 71 2011.08
Interleukin-19 is a Negative Regulator of Innate Immunity and Critical for Colonic Protection Reviewed
Azuma YT, Matsuo Y, Nakajima H, Yacopouls DG, Valenzuela DM, Murphy AJ, Karow M, Takeuchi T.
J. Pharmacol. Sci. 雑誌 The Japanese Parmacological Society 113 ( 2 ) 105 - 111 2011.01
Nitric oxide and carbon monoxide act as inhibitory neurotransmitters in the longitudinal muscle of C57BL/6J mouse distal colon. Reviewed
Hidaka A, Azuma YT, Nakajima H, Takeuchi T.
J. Pharmacol. Sci. 雑誌 The Japanese Parmacological Society 112 ( 2 ) 231 - 241 2010.10
IL-19遺伝子欠損マウスにおけるDSS誘発性大腸炎の増悪 Reviewed
東 泰孝、松尾有希子、桑村 充、中嶋秀満、竹内正吉
消化器免疫 雑誌 日本消化器免疫学会 46 131 - 134 2010.07
PPARa contributes to colonic protection in mice with DSS-induced colitis Reviewed
Azuma YT, Nishiyama K, Matsuo Y, Kuwamura M, Morioka A, Nakajima H, Takeuchi T.
Int. Immunopharmacol. 雑誌 ELSEVIER SCIENCE LTD 10 ( 10 ) 1261 - 1267 2010.07
解糖系酵素glyceraldehyde-3-phosphate dehydrogenase (GAPDH) の多機能性と酸化ストレス性細胞死における役割 Reviewed
中嶋秀満、東 泰孝、竹内正吉
放射線生物研究 雑誌 日本放射線生物学会 45 ( 2 ) 127 - 139 2010.07
Interleukin-19 protects mice from innate-mediated colonic inflammation. Reviewed
Azuma YT, Matsuo Y, Kuwamura M, Yacopouls DG, Valenzuela DM, Murphy AJ, Nakajima H, Takeuchi T.
Inflammatory Bowel Diseases 雑誌 WILEY-LISS, DIV JOHN WILEY & SONS INC 16 ( 6 ) 1017 - 1028 2010.07
An aggregate-prone mutant of human glyceraldehyde-3-phosphate dehydrogenase augments oxidative stress-induced cell death in SH-SY5Y cells. Reviewed
Nakajima H, Amano W, Fukuhara A, Kubo T, Misaki S, Azuma YT, Inui T, Takeuchi T.
Biochem. Biophys. Res. Commun. 雑誌 ELSEVIER SCIENCE LTD 390 ( 3 ) 1066 - 1071 2009.12
GAPDH aggregate formation participates in oxidative stress-induced cell death (in press) Reviewed
Hidemitsu Nakajima, Wataru Amano, Takeya Kubo, Ayano Fukuhara, Hideshi Ihara, Yasu-Taka Azuma, Hisao Tajima, Takashi Inui, Akira Sawa, and Tadayoshi Takeuchi1
J. Biol. Chem. 雑誌 The American Society for Biochemistry and Molecular Biology (ASBMB) 284 ( 49 ) 34331 - 34341 2009.10
PACAP欠損マウスにおけるDSS誘発性腸炎の増悪． Reviewed
東 泰孝、新谷紀人、桑村 充、中嶋秀満、橋本 均、馬場明道、竹内正吉
消化器と免疫 著書 日本消化器免疫学会 45 ( 1 ) 134 - 138 2009.01
The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse. Reviewed
Tadayoshi Takeuchi, Noriyuki Yamashiro, Tetsuya Kawasaki, Hidemitsu Nakajima, Yasu-Taka Azuma, Minoru Matsui
Neuroscience 雑誌 PERGAMON-ELSEVIER SCIENCE LTD 156 ( 2 ) 381 - 389 2008.10
Involvements of PHI-nitric oxide and PACAP-BK channel in the sustained relaxation of mouse gastric fundus. Reviewed
Kiyomi Hagi, Yasu-Taka Azuma, Hidemitsu Nakajima, Norihito Shintani, Hitoshi Hashimoto, Akemichi Baba and Tadayoshi Takeuchi
Eur. J. Pharmacol. 雑誌 ELSEVIER SCIENCE LTD 590 ( 6 ) 80 - 86 2008.08
PACAP provides colonic protection against dextran sodium sulfate induced colitis. Reviewed
Yasu-Taka Azuma, Kiyomi Hagi, Norihito Shintani, Mitsuru Kuwamura, Hidemitsu Nakajima, Hitoshi Hashimoto, Akemichi Baba and Tadayoshi Takeuchi
J. Cell. Physiol. 雑誌 WILEY-LISS, DIV JOHN WILEY & SONS INC 216 ( 1 ) 111 - 119 2008.07
Functional interaction between SK2 channel and the nicotinic acetylcholine receptor in enteric neurons of the guinea pig ileum Reviewed
Hidemitsu Nakajima, Hiroto Gotoh, Akikazu Fujita, Yasu-Taka Azuma, and Tadayoshi Takeuchi
J. Neurochem 雑誌 BLACKWELL PUBLISHING 103 ( 6 ) 2428 - 2438 2007.12
Distribution and immunohistochemical localization of GDNF protein in selected neural and non-neural tissues of rats during development and its changes with a unilateral 6-hydroxydopamine lesion. Reviewed
Ritsuko Katoh-Semba, Masako Tsuzuki, Noriko Miyazaki, Akiko Yoshida, Hidemitsu Nakajima, Chiaki Nakagawa, Satoko Kitajima, and Motoko Matsuda
Neurosci. Res. 雑誌 ELSEVIER SCIENCE LTD 59 ( 3 ) 277 - 287 2007.11
The active site cysteine of the proapoptotic protein glyceraldehyde-3-phosphate dehydrogenase is essential in oxidative stress-induced aggregation and cell death. Reviewed
Hidemitsu Nakajima, Wataru Amana, Akikazu Fujita, Ayano Fukuhara, Yasu-Taka Azuma, Fumiaki Hata, Takashi Inui, and Tadayoshi Takeuchi
J. Biol. Chem. 雑誌 The American Society for Biochemistry and Molecular Biology (ASBMB) 282 ( 36 ) 26562 - 74 2007.09
A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon Reviewed
Tadayoshi Takeuchi, Hidemitsu Nakajima, Fumiaki Hata and Yasu-Taka Azuma
Pflugers Arch. 雑誌 SPRINGER 454 ( 4 ) 565 - 574 2007.07
Synthesis and biological activities of novel furo[2,3,4-jk][2]benzazepin-4(3H)-one derivatives. Reviewed
Kumiko Ando, Yukiko Akai, Jun-ichi Kunitomo, Takehiko Yokomizo, Hidemitsu Nakajima, Tadayoshi Takeuchi, Masayuki Yamashita, Shunsaku Ohta, Takahiro Ohishi and Yoshitaka Ohishi
Org. Biomol. Chem. 雑誌 ROYAL SOC CHEMISTRY 5 ( 4 ) 655 - 663 2007.02
M2 and M3 muscarinic receptors are involved in enteric nerve-mediated contraction of the mouse ileum: findings obtained using muscarinic receptor knockout mouse Reviewed
Tadayoshi Takeuchi, Keisuke Tanaka, Hidemitsu Nakajima, Minoru Matsui, and Yasu-Taka Azuma
Am. J. Physiol. Gastrointest Liver Physiol, 雑誌 The American Physiological Society 292 ( 1 ) 154 - 164 2007.01
Orexin A affects ascending contration depending on downstream cholinergic neurons and descending relaxation through independent pathways in mouse jejunum Reviewed
Yuji Satoh, Yutaka Okishio, Yasu-Taka Azuma, Hidemitsu Nakajima, Fumiaki Hata, and Tadayoshi Takeuchi
Neuropharmacology 雑誌 ELSEVIER SCIENCE LTD 51 ( 3 ) 466 - 473 2006.09
Inhibitory effects of alendronate on cholinergic responses in rat lower esophageal sphincter. Reviewed
Tadayoshi Takeuchi, Aki Nakamura, Hidemitsu Nakajima, Yasu-Taka Azuma, and Fumiaki Hata
Eur. J. Pharmacol. 雑誌 ELSEVIER SCIENCE LTD 537 ( 1-3 ) 155 - 159 2006.05
Involvement of M(2) muscarinic receptors in relaxant response of circular muscle of mouse gastric antrum Reviewed
Tadayoshi Takeuchi, Makiko Toyoshima, Kazunori Mukai, Kiyomi Hagi, Minoru Matsui, Hidemitsu Nakajima, Yasu-Taka Azuma, and Fumiaki Hata
Neurogastroenterol. Motil. 雑誌 ELSEVIER SCIENCE LTD 18 ( 3 ) 226 - 233 2006.03
A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats Reviewed
Hidemitsu Nakajima, Nobukazu Kakui, Kunihiro Ohkuma, Midori Ishikawa, and Toshifumi Hasegawa
J. Pharmacol. Exp. Ther. 雑誌 The American Society for Pahrmacology and Experimental Pharmaceutics (ASPET) 312 ( 2 ) 472 - 481 2005.02
Critical role of the automodification of poly(ADP-ribose) polymerase-1 in nuclear factor-kappaB-dependent gene expression in primary cultured mouse glial cells. Reviewed
Hidemitsu Nakajima, Hiroshi Nagaso, Nobukazu Kakui, Midori Ishikawa, Toyokazu Hiranuma, Shigeru Hoshiko
J. Biol. Chem. 雑誌 The American Society for Biochemistry and Molecular Biology (ASBMB) 279 ( 41 ) 42774 - 86 2004.10
Critical role of sulfenic acid formation of thiols in the inactivation of glyceraldehyde-3-phosphate dehydrogenase by nitric oxide. Reviewed
Toshiaki Ishii, Osamu Sunami, Hidemitsu Nakajima, Hideaki Nishio, Tadayoshi Takeuchi, and Fumiaki Hata
Biochem. Pharmacol. 雑誌 ELSEVIER SCIENCE LTD 58 ( 1 ) 133 - 143 1999.07
Cyclic GMP and relaxation of rat colonic smooth muscle Reviewed
Tadayoshi T, Nakajima H, Kichi M, Sumiyoshi M, Hata F.
J. Smooth Muscle Res. 雑誌 日本平滑筋学会機関誌 36 ( 6 ) 465 - 467 1995.09
Involvement of heterotrimeric GTP-binding protein and rho protein, but not protein kinase C, in agonist-induced Ca2+ sensitization of skinned muscle of guinea pig vas deferens. Reviewed
Akikazu Fujita, Tadayoshi Takeuchi, Hidemitsu Nakajima, Hideaki Hishio, and Fumiaki Hata
J. Pharmacol. Exp. Ther. 雑誌 The American Society for Pahrmacology and Experimental Pharmaceutics (ASPET) 274 ( 1 ) 555 - 561 1995.01
薬理学・毒性学実験 第４版
中嶋秀満（ Role： Contributor , 動物の麻酔・動物の安楽死）
日本獣医薬理学・毒性学会 2023.03
Botulinum Toxin
Nikolay Serdev, Michel R. Popoff, Giovanna Fico, Hidemitsu Nakajima, Ronald Feiner, Hsien-Li Peter Peng, Diana Mostafa, Daniel Mondlak Algazi, Tariq F. Al-Shaiji（ Role： Joint author）
InTechOpen 2018.08
獣医薬理学 第3版
日本比較薬理学・毒性学会（ Role： Joint author）
文永堂出版株式会社 2012.04
薬理学・毒性学実験 第3版
日本比較薬理学・毒性学会（ Role： Joint author）
文永堂出版株式会社 2008.04
活性イオウ分子を基軸とした大豆たん白質および関連成分の基礎的研究—Fundamental Research on Soy Protein and Related Components Based on Reactive Sulfur Species—第24回研究報告会記録
居原 秀, 赤池 孝章, 中嶋 秀満, 笠松 真吾
大豆たん白質研究 / 不二たん白質研究振興財団 [編] 24 ( 42 ) 1 - 5 2022.07（ ISSN:1344-4050 ）
アルツハイマー病およびてんかんモデルマウスにおける8-nitro-cGMP産生と神経活動への影響
居原秀, 岸本祐典, 笠松真吾, 中嶋秀満, 赤池孝章
日本NO学会学術集会プログラム抄録集 19th 2019
NASHモデルを用いたIL-19が病態形成に及ぼす影響
牛飼裕美, 藤本泰之, 井澤武史, 桑村充, 中嶋秀満, 竹内正吉, 東泰孝
日本獣医学会学術集会講演要旨集 162nd 2019（ ISSN:1347-8621 ）
多機能性酵素GAPDHのレドックス制御と脳神経疾患-GAPDHカスケードを標的とした創薬研究と治療戦略- Invited
中嶋秀満
大阪大学 蛋白質研究所 高次脳機能学セミナー 2023.03 大阪大学 蛋白質研究所 高次脳機能 疋田貴俊教授
多機能性酵素GAPDHのレドックス制御と脳神経疾患-GAPDHカスケードを標的とした創薬研究と治療戦略- Invited
中嶋秀満
大阪大学 蛋白質研究所 高次脳機能学セミナー 2023.03
牛飼 裕美, 藤本 泰之, 井澤 武史, 桑村 充, 中嶋 秀満, 竹内 正吉, 東 泰孝
日本獣医学会学術集会講演要旨集 2019.08 (公社)日本獣医学会
Oxidative stress-induced GAPDH nuclear translocation in the hippocampus causes depression behaviors by GR and BDNF downregulation in stressed mice. (Best Poster Award) Invited
Shoji M, and Nakajima H. et al.
Internatinal Conference on Alzheimer’s Disease & Dementia2019 2019.07
Nishiyama Kazuhiro, Azuma Yasu-taka, Nakajima Hidemitsu, Takeuchi Tadayoshi
The Journal of Physiological Sciences 2019.06 (一社)日本生理学会
Non-peptidic GAPDH aggregation inhibitor
Hidemitsu Nakajima
非ペプチド性GAPDH凝集阻害剤
中嶋秀満
GAPDH凝集阻害薬に関する創薬研究
PARP-1に関する研究
GAPDHに関する研究
Therapeutic strategy in brain amyloidosis based on the GAPDH aggregate common cross-seed hypothesis
Grant-in-Aid for Scientific Research(A) 2024
活性イオウ分子を基軸とした大豆たん白質および関連成分の基礎的研究
公益財団法人不二たん白質研究振興財団 公益財団法人不二たん白質研究振興財団 令和2年度 研究助成課題 2022.04
細胞の液-液相分離現象にフォー カスした新規治療薬の開発
AMED橋渡し研究プログラム異分野融合型研究開発推進支援事業 AMED橋渡し研究プログラム異分野融合型研究開発推進支援事業 2022.09
獣医科学英語演習
2024 Intensive lecture Undergraduate
動物行動解析学
2024 Intensive lecture Undergraduate
小動物基礎臨床実習
2022 Intensive lecture Undergraduate
動物行動解析学
2022 Intensive lecture Undergraduate
基礎動物生理学
2022 Weekly class Undergraduate
獣医体験演習
2022 Weekly class Undergraduate
獣医科学特別研究1
2022 Intensive lecture Graduate school
獣医科学特別演習1
2022 Intensive lecture Graduate school
国際・国内インターンシップ
2022 Intensive lecture Graduate school
獣医科学特別研究1
2022 Intensive lecture Graduate school
生物学A獣医
2022 Intensive lecture Graduate school
発生学
2022 Weekly class Undergraduate
Biology A
2021
Animal Physiology on Basic
2021
Veterinary Embryology
2021
Veterinary Embryology
2021
生体高分子機能学特論
動物行動解析学
実験動物学
神経内分泌学
獣医薬理学
創薬科学研究所の運営・シンポジウムの開催 2022
2019
Number of instructed the graduation thesis：3 Number of graduation thesis reviews：3
2018
Number of instructed the graduation thesis：5 Number of graduation thesis reviews：3
[Number of instructed the Master's Program] (letter term)：1
[Number of master's thesis reviews] (chief)：3
2017
Number of instructed the graduation thesis：5 Number of graduation thesis reviews：3
[Number of instructed the Master's Program] (letter term)：2
[Number of master's thesis reviews] (chief)：3
[Number of doctoral thesis reviews] (vice-chief)：1
2016
Number of instructed the graduation thesis：5 Number of graduation thesis reviews：3
[Number of instructed the Master's Program] (letter term)：2
2015
Number of instructed the graduation thesis：4 Number of graduation thesis reviews：2
[Number of instructed the Master's Program] (letter term)：2
2014
Number of instructed the graduation thesis：4 Number of graduation thesis reviews：2
[Number of instructed the Master's Program] (letter term)：2
[Number of master's thesis reviews] (chief)：2
2013
Number of instructed the graduation thesis：2 Number of graduation thesis reviews：2
[Number of instructed the Master's Program] (letter term)：2
[Number of master's thesis reviews] (chief)：2
2012
Number of instructed the graduation thesis：4 Number of graduation thesis reviews：2
[Number of instructed the Master's Program] (letter term)：2
[Number of master's thesis reviews] (chief)：2
2011
Number of instructed the graduation thesis：4 Number of graduation thesis reviews：2
[Number of instructed the Master's Program] (letter term)：2
[Number of master's thesis reviews] (vice-chief)：2
2010
Number of instructed the graduation thesis：3 Number of graduation thesis reviews：2
[Number of instructed the Master's Program] (letter term)：1
[Number of master's thesis reviews] (chief)：2
2022
Original item：担当講義・実習に関する学生の理解度・満足度・時間外学習の向上に向けた個別アンケートの実施
Special report：「授業外時間学習時間の平均値向上」をかかげ、講義前に予習用教材アップロードとアナウンスメントを実施した結果、てぃら・みすデータでは動物行動解析学1.71→2.82および基礎動物生理学2.22→2.67と改善傾向がみられたものの、部局内平均（各2.73、2.46）に到達したに過ぎず、次年度への課題となった。また、個別に「講義理解度」（Q1-6）および「講義満足度」（Q1-8）を集計したところ、動物行動解析学：理解度4.83（4.46）満足度5.00（4.92）（回答率57%）、基礎動物生理学：理解度5.29（4.58）満足度5.67（5.03）（回答率75%）（数字後の括弧内は部局内平均値）という結果となり、平均を上回る結果を得た。
日本獣医学会 評議員
日本獣医学会 2010.04 - Now
SDGs：
日本薬理学会 評議員
日本薬理学会 2010.04 - Now
SDGs：
AMED『橋渡し研究プログラム異分野融合型研究開発推進支援事業』に2件の研究課題が採択 Internet
大阪公立大学 大阪公立大学 学術研究推進本部 URAセンター 大阪公立大学 最新の研究成果 2022.09
SDGs：
Current Medicinal Chemistry, Histology and Histopathology, Current Molecular Medicine, Global Journal of Medical and Clinical Case Reports, Anti-Cancer Agents in Medicinal Chemistry, Current Drug Metabolism, Current Protein & Peptide Science, Current Alzheimer Research, Journal of Biology and Medicine,
Role(s)： Peer review
2022.04 - 2023.03
研究職歴
2010.04 - Now
大阪府立大学 生命環境科学研究科 獣医学専攻 統合バイオ機能学講座（応用薬理学） 准教授