School of Science Department of Biological Chemistry

Updated on 2025/03/15
Graduate School of Science Department of Biological Chemistry
Professor 2022.04 - Now
School of Science Department of Biological Chemistry
Professor 2022.04 - Now
博士(工学) ( Others )
Life Science / Pharmaceutical chemistry and drug development sciences / Medicinal Chemistry
Life Science / Structural biochemistry / Strucutral Biology
Life Science / Pharmaceutical chemistry and drug development sciences
Life Science / Structural biochemistry
Nanotechnology/Materials / Chemical biology
protein kinases
Structural Biology
シグナル伝達
X線結晶構造解析
Structure-based drug discovery
キナーゼの活性制御における分子メカニズム解明と創薬
日本ペプチド学会
2016.04 - Now Domestic
CBI学会
2013.04 - Now Domestic
日本蛋白質科学会
2005.04 - Now Domestic
日本生化学会
2005.04 - Now Domestic
American Chemical Society
2005.04 - Now Overseas
日本薬学会
1994.04 - Now Domestic
日本結晶学会
1994.04 - Now Domestic
2025年度大会プログラム委員 CBI学会
2025.01 - Now
関西支部運営委員 支部長 CBI学会
2024.11 - Now
2024年度大会プログラム委員 CBI学会
2024.01 - 2024.10
広報委員 日本結晶学会
2020.04 - 2022.03
関西支部運営委員 CBI学会
2015.04 - 2024.10
第10回日本蛋白質科学会年会ポスター賞
2010.06 日本蛋白質科学会
構造活性相関シンポジウムポスター賞
2008 日本薬学会構造活性相関部会
Breakthrough award, division of medicinal chemistry, PSJ in 2005
2005.11
Deep mutational scanning-guided design of a high-affinity helix–loop–helix peptide targeting G-CSF receptor Reviewed
M. Michigami, Y. Kanata, C.I. Ven, A. Oshima, A. Yamaguchi-Nomoto, T. Kinoshita, T. Hirokawa, I. Fujii
Bioorg. Med. Chem. Lett. 117 130071 2025.02
Structural insights into helix–loop–helix peptides for “ligand-targeting” intracellular drug delivery via VEGF receptor-mediated endocytosis Reviewed
M. Michigami, R. Kira, M. Kamo, T. Hirokawa, T. Kinoshita, K. Inaka, I. Nakase, I. Fujii
Biochem. Biophys. Res. Commun. 741 150980 2024.11
Structural insights into molecular-targeting helix–loop–helix peptide against vascular endothelial growth factor-A Reviewed
M. Michigami, K. Notsu, M. Kamo, T. Hirokawa, T. Kinoshita, K. Inaka, I. Nakase, I. Fujii
Biochem. Biophys. Res. Commun. 734 150749 2024.10
Compounds designs of CK2α inhibitors derived from virtual screening hit compounds by computational chemistry with crystallography Reviewed
S. Nakamura, K. Nishiwaki, M. Tsuyuguchi, T. Kinoshita, S. Oishi, H. Ohno, I. Nakanishi
Chem. Pharm. Bull. 72 776 - 780 2024.08
Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors Reviewed
S. Yumura, D. Kitagawa, K. Moritsugu, A. Nakayama, T. Shinada, M. Sawa, T. Kinoshita
Bioorg. Med. Chem. Lett. 112 129914 2024.08
Enhanced inhibitory activity of compounds containing purine scaffolds compared to protein kinase CK2α considering crystalline water Reviewed
K. Nishiwaki, S. Nakatani, S. Nakamura, K. Yoshioka, E. Nakagawa, M. Tsuyuguchi, T. Kinoshita, I. Nakanishi
RSC Med. Chem. 15 1274 - 1282 2024.06
Distinct binding modes of a benzothiazole derivative confer structural bases for increasing ERK2 or p38α MAPK selectivity Reviewed
S. Hasegawa, M. Yoshida, H. Nagao, H. Sugiyama, M. Sawa, T. Kinoshita
Biochem. Biophys. Res. Commun. 704 149707 - 149707 2024.02
Low entropic cost of binding confers high selectivity on an allosteric ERK2 inhibitor Reviewed
H. Sugiyama, M. Yoshida, H. Nagao, M. Sawa, T. Kinoshita,
Bioorg. Med. Chem. Lett. 93 129431 - 129431 2023.08
Design, synthesis and structure-activity relationship studies of protein kinase CK2 inhibitors containing a purine scaffold Reviewed
2. K. Nishiwaki, S. Nakamura, K. Yoshioka, E. Nakagawa, S. Nakatani, M. Tsuyuguchi, T. Kinoshita, I. Nakanishi
Chem. Pharm. Bull. 71 558 - 565 2023.07
Asaka Ikeda, Masato Tsuyuguchi, Daisuke Kitagawa, Masaaki Sawa, Shinya Nakamura, Isao Nakanishi, Takayoshi Kinoshita
Biochemical and biophysical research communications 630 30 - 35 2022.11( ISSN:0006291X )
Identification of a novel target site for ATP-independent ERK2 inhibitors Reviewed
M. Yoshida, H. Nagao, H. Sugiyama, M. Sawa, T. Kinoshita
Biochem. Biophys. Res. Commun. 593 73 - 78 2022.04
Identification of an allosteric and Smad3-selective inhibitor of p38aMAPK using a substrate-based approach Reviewed
H. Nagao, D. Kitagawa, F. Nakajima, M. Sawa, T. Kinoshita
Bioorg. Med. Chem. Lett. 雑誌 31 2021.04
Structural basis for producing selective MAP2K7 inhibitors Reviewed
Y. Murakawa, S. Valter, H. Barr, N. London, T. Kinoshita
Bioorg. Med. Chem. Lett. 雑誌 30 2020.11
Structural insights for producing CK2a1-specific inhibitors Reviewed
M. Tsuyuguchi, T. Nakaniwa, A. Hirasawa, I. Nakanishi, T. Kinoshita
Bioorg. Med. Chem. Lett. 雑誌 30 2020.02
Ensemble structural analyses depict the regulatory mechanism of non-phosphorylated human MAP2K4 Reviewed
T. Matsumoto, A. Yamano, Y. Murakawa, H. Fukada, M. Sawa, T. Kinoshita
Biochem. Biophys. Res. Commun. 雑誌 521 106 - 112 2020.01
An isoform-selective inhibitor of tropomyosin receptor kinase A behaves as molecular glue Reviewed
N. Furuya, T. Momose, K. Katsuno, N. Fushimi, H. Muranaka, C. Handa, M. Sawa, T. Ozawa, T. Kinoshita
Bioorg. Med. Chem. Lett. 雑誌 30 2020.01
Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth
Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A. Kay, Kenichiro Itami, Tsuyoshi Hirota
Science Advances 5 ( 1 ) 2019.01( eISSN:2375-2548 )
Covalent docking identifies a potent and selective MKK7 inhibitor Reviewed
A. Shraga, E. Olhavang, N. Davidzohn, P. Khoshkenar, N. Germain, K. Shurrush, S. Carvalho, L. Avram, S. Albeck, T. Unger, B. Lefker, C. Subramanyam, R.H. Hudkins, A. Mitchell, Z. Shulman, T. Kinoshita, N. London
Cell Chem. Biol. 雑誌 26 98 - 108 2019.01
A microgravity environment improves structural resolution and endows cues for specific inhibition of mitogen-activated protein kinase kinase 7 Reviewed
T. Kinoshita, T. Hashimoto, Y. Murakawa, Y. Sogabe, T. Matsumoto, M. Sawa
Int. J. Microgravity Sci. Appl. 雑誌 36 2019.01
A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1
Masato Tsuyuguchi, Tetsuko Nakaniwa, Masaaki Sawa, Isao Nakanishi, Takayoshi Kinoshita
Acta Crystallographica Section F: Structural Biology Communications 75 515 - 519 2019( eISSN:2053-230X )
Hydration structures of the human protein kinase CK2a clarified by joint neutron and X-ray crystallography Reviewed
C. Shibasaki, S. Arai, R. Shimizu, M. Saeki, T. Kinoshita, A. Ostermann, T.E. Schrader, Y. Kurosaki, T. Sunami, R. Kuroki, M. Adachi
J. Mol. Biol. 雑誌 430 5094 - 5104 2018.07
Crystal structures of human CK2a2 in new crystal forms arising from a subtle difference in salt concentration Reviewed
M. Tsuyuguchi, T. Nakaniwa, T. Kinoshita
Acta Cryst. 雑誌 F74 288 - 293 2018.06
Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model Reviewed
A. Nishiyama, T. Yamada, K. Kita, R. Wang, S. Arai, K. Fukuda, A. Tanimoto, S. Takeuchi, S. Tange, A. Tajima, N. Furuya, T. Kinoshita, S. Yano
Clinical Cancer Res. 雑誌 24 2357 - 2369 2018.05
High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7 Reviewed
T. Kinoshita, T. Hashimoto, Y. Sogabe, H. Fukada, T. Matsumoto, M. Sawa
Biochem. Biophys. Res. Commun. 雑誌 493 313 - 317 2017.06
The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity Reviewed
N. Furuya, T. Momose, K. Katsuno, N. Fushimi, H. Muranaka, C. Handa, T. Ozawa, T. Kinoshit
Bioorg. Med. Chem. Lett. 雑誌 27 1233 - 1236 2017.01
A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Reviewed
Y. Sogabe, T. Hashimoto, T. Matsumoto, Y. Kirii, M. Sawa, T. Kinoshita
Biochem. Biophys. Res. Commun. 雑誌 473 476 - 481 2016.10
Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inihibitors Reviewed
H. Ohno, D. Minamiguchi, S. Nakamura, K. Shu, S. Okazaki, M. Honda, R. Misu, H. Moriwaki, S. Nakanishi, S. Oishi, T. Kinoshita, I. Nakanishi, N. Fujii
Bioorg. Med. Chem. 雑誌 24 1136 - 1141 2016.03
Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay Reviewed
T. Kinoshita, H. Sugiyama, Y. Mori, N. Takahashi, A. Tomonaga
Bioorg. Med. Chem. Lett. 雑誌 26 955 - 958 2016.02
Bioconversion of FR901459, a novel derivative of cyclosporine A, by Lenzea sp. 7887 Reviewed
S. Sasamura, M. Kobayashi, H. Muramatsu, S. Yoshimura, T. Kinoshita, H. Ohki, K. Okada, Y. Deai, Y. Yamagishi, M. Hashimoto
J. Antibiot. 雑誌 68 511 - 520 2015.07
Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening Reviewed
I. Nakanishi, K. Murata, N. Nagata, M. Kurono, T. Kinoshita, M. Yasue, T. Miyazaki, Y. Takei, S. Nakamura, A. Sakurai, N. Iwamoto, N. Nishiwaki, T. Nakaniwa, Y. Sekiguchi, A. Hirasawa, G. Tsujimoto, K. Kitaura
Eur. J. Med. Chem. 雑誌 96 396 - 404 2015.04
5Z-7-oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner Reviewed
Y. Sogabe, T. Matsumoto, T. Hashimoto, Y. Kirii, M. Sawa, T. Kinoshita
Bioorg. Med. Chem. Lett. 25 593 - 596 2015.01
Hepatocyte growth factor Reviewed
K. Sakai, T. Kinoshita, K. Matsumoto
References Module in Biological Sciences 2014.12
Crystal structure of human CK2a at 1,06A resolution Reviewed
T. Kinoshita, T. Nakaniwa, Y. Sekiguchi, Y. Sogabe, A. Sakurai, S. Nakamura, I. Nakanishi
J. Synchrotron Rad. 20 974 - 979 2013.12
ヒトMAPキナーゼJNK1の立体構造・機能・安定性に対する遊離システイン残基の置換効果 Reviewed
仲庭哲津子、深田はるみ、黒木良太、木下誉富
日本結晶学会誌 日本結晶学会 55 197 - 202 2013.06
Seven cysteine-deficient mutants depict interplay between thermal and chemical stabilities of individual cysteine residues in MAP kinase JNK1 Reviewed
T. Nakaniwa, H. Fukada, T. Inoue, M. Gouda, R. Nakai, Y. Kirii, M. Adachi, T. Tamada, S. Segawa, R. Kuroki, T. Tada, T. Kinoshita
Biochemistry 51 8410 - 8421 2012.10
The in silico screening and X-ray structure analysis and the inhibitor complex of plasmodium falciparum orotidine-5'-monophosphate decarboxylase Reviewed
Y. Takashima, E. Mizohata, S.R. Krunkrai, Y. Fukunishi, T. Kinoshita, T. Sakata, H. Matsumra, J. Krungkrai, T. Horii, T. Inoue
J. Biochem. 152 133 - 138 2012.08
Crystal and solution structures disclose a putative transient state of mitogen-activated kinase kinase 4 Reviewed
T. Matsumoto, T. Kinoshita, Y. Kirii, T. Tada, A. Yamano
Biochem. Biophys. Res. Commun. 425 195 - 200 2012.08
Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state Reviewed
T. Matsumoto, T. Kinoshita, H. Furukawa, R. Nakai, Y. Kirii, K. Yokota, T. Tada
J. Biochem. 151 541 - 549 2012.05
Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scafolds Reviewed
Z. Hou, I. Nakanishi, T. Kinoshita, Y. Takei, M. Yasue, R. Misu, Y. Suzuki, S. Nakamura, T. Kure, H. Ohno, K. Murata, K. Kitaura, A. Hirasawa, G. Tsujimoto, S. Oishi, N. Fujii
J. Med. Chem. 55 2899 - 2903 2012.03
Knowledge-based identification of the ERK2/STAT3 signal pathway as a therapeutic target for type 2 diabates and drug discovery Reviewed
T. Kinoshita, K. Doi, H. Sugiyama, S. Kinoshita, M. Wada, S. Naruto, T. Tomonaga
Chem. Biol. Drug Des. 78 471 - 476 2011.09
A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase Reviewed
T. Kinoshita, Y. Sekiguchi, H. Fukada, T. Nakaniwa, T. Tada, S. Nakamura, K. Kitaura, H. Ohno, Y. Suzuki, A. Hirasawa, I. Nakanishi, G. Tsujimoto
Mol. Cell. Biochem. 356 97 - 105 2011.09
HGF-antagonists: structure, activities, and anti-cancer approach Reviewed
K. Sakai, T. Nakamura, T. Kinoshita, T. Nakamura, K. Matsumoto
Current Signal Transduction Therapy 6 191 - 199 2011.05
High resolution structure of exo-arabinanase from Penicillium chrysogenum Reviewed
Y. Sogabe, T. Kitatani, A. Yamaguchi, T. Kinoshita, H. Adachi, K. Takano, T. Inoue, Y. Mori, H. Matsumura, T. Sakamoto, T. Tada
Acta Cryst. D67 415 - 422 2011.04
Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state Reviewed
T. Matsumoto, T. Kinoshita, Y. Kirii, K. Yokota, K. Hamada, T. Tada
Biochem. Biophys. Res. Commun. 400 369 - 373 2010.08
中性子構造解析および超高分解能X線構造解析によるエラスターゼの機能解明 Reviewed
玉田太郎、黒木良太、木下誉富、多田俊治
日本結晶学会誌 日本結晶学会 52 ( 2 ) 133 - 138 2010.04
A silent mutation allows efficient production of active human Frk tyrosine kinase in Escheria coli Reviewed
X. Yang, T. Kinoshita, M. Gouda, K. Yokota, T. Tada
Biosci. Biotechnol. Biochem. 74 125 - 128 2010.02
創薬バリューチェインのインシリコ技術を活用した阻害剤開発の試み Reviewed
井上豪、松村浩由、安達宏昭、森勇介、高野和文、村上聡、福西快文、中村春木、木下誉富、仲西功、奥野恭史、南方聖司、三上義明、佐久間俊広、北島正人、福岡良忠、高田俊和、坂田恒昭
日本結晶学会誌 日本結晶学会 52 ( 1 ) 89 - 94 2010.02
Structure basis for the inhibitor recognition of human Lyn kinase domain Reviewed
N. Miyano, T.Kinoshita, R. Nakai, Y. Kirii, K. Yokota, T. Tada
Bioorg. Med. Chem. Lett. 19 6557 - 6560 2009.11
Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond Reviewed
T. Tamada, T. Kinoshita, K. Kurihara, M. Adachi, T. Ohhara, K. Imai, R. Kuroki, T. Tada
J. Am. Chem. Soc. 131 11033 - 11040 2009.08
Structural insight into human CK2a in complex with the potent inhibitor ellagic acid Reviewed
Y. Sekiguchi, T. Nakaniwa, T. Kinoshita, I. Nakanishi, K. Kitaura, A. Hirasawa, G. Tsujimoto, T. Tada
Bioorg. Med. Chem. Lett. 19 2920 - 2923 2009.05
Structure of human protein kinase CK2a2 with a potent indazole-derivative inhibitor Reviewed
T. Nakaniwa, T. Kinoshita, Y. Sekiguchi, T. Tada, I. Nakanishi, K. Kitaura, Y. Suzuki, H. Ohno, A. Hirasawa, G. Tsujimoto
Acta Cryst. F65 75 - 79 2009.02
Crystal structure of human mono-phosphorylated ERK1 at Tyr204 Reviewed
T. Kinoshita, I. Yoshida, S. Nakae, K. Okita, M. Gouda, M. Matsubara, K. Yokota, H. Ishiguro, T. Tada
Biochem. Biophys. Res. Commun. 377 1123 - 1127 2008.12
Conformation change of adenosine deaminase during ligand-exchange in a crystal Reviewed
T. Kinoshita, T. Tada, I. Nakanishi
Biochem. Biophys. Res. Commun. 373 53 - 57 2008.07
Protein purification and preliminary crystallographic analysis of human Lyn tyrosine kinase Reviewed
T. Kinoshita, N. Miyano, R. Nakai, K. Yokota, H. Ishiguro, T. Tada
Protein Expr. Purif. 58 318 - 324 2008.03
Crystallization of porcine pancreatic elastase and preliminary neutron diffraction experiment Reviewed
T. Kinoshita, T. Tamada, K. Imai, K. Kurihara, T. Ohhara, T. Tada, R. Kuroki
Acta Cryst. F63 315 - 317 2007.04
Role of a cystein residue in the active site of ERK and the MAPKK family Reviewed
M. Ohori, T. Kinoshita, S. Yoshimura, M. Warizaya, H. Nakajima, H. Miyake
Biochem. Biophys. Res. Commun. 353 633 - 637 2007.02
Structure of human Fyn kinase domain complexed with staurosporine Reviewed
T. Kinoshita, M. Matsubara, H. Ishiguro, K. Okita, T. Tada
Biochem. Biophys. Res. Commun. 346 840 - 844 2006.08
Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7992 Reviewed
T. Kitatani, Y. Nakamura, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka, T. Tada
Acta Cryst. F62 727 - 730 2006.08
Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase Reviewed
T. Kinoshita, A. Yamaguchi, T. Tada
Acta Cryst. F62 623 - 626 2006.07
Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938 Reviewed
M. Kuno, N. Seki, S. Tsujimoto, I. Nakanishi, T. Kinoshita, K. Nakamura, T. Terasaka, N. Nishio, A. Sato, T. Fujii
Eur. J. Pharmcol. 534 241 - 249 2006.04
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling Reviewed
J. Ishida, H. Yamamoto, Y. Kido, K. Kamijo, K. Murano, H. Miyake, M. Okubo, T. Kinoshita, M. Warizaya, A. Iwashita, K. Mihara, N. Matsuoka, K. Hattori
Bioorg. Med. Chem. 14 1378 - 1390 2006.03
Structure of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942 complexed with NADP Reviewed
T. Kitatani, Y. Nakamura, K. Wada, T. Kinoshita, S. Shigeoka, T. Tada
Acta Cryst. F62 315 - 319 2006.03
Crystal structure of human ERK2 complexed with a pyrazolo[3,4c]pyridazine derivative Reviewed
T. Kinoshita, M. Warizaya, M. Ohori, K. Sato, M. Neya, T. Fujii
Bioorg.Med. Chem. Lett. 16 55 - 58 2006.01
Solution-Stirring Method Improves Crystal Quality of Human Triosephosphate Isomerase Reviewed
H. Adachi, A. Niino, T. Kinoshita, M. Warizaya, R. Maruki, K. Takano, H. Matsumura, T. Inoue, S. Murakami, Y. Mori, T. Sasaki
J. Biosci. Bioeng. 101 83 - 86 2006.01
Protein Crystallization by combining laser irradiation and solution-stirring techniques Reviewed
H. Adachi, A. Niino, S. Murakami, K. Takano, H. Matsumura, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori and T. Sasaki
Jpn. J. Appl. Phys. 44 1365 - 1366 2005.12
Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors Reviewed
A. Iwashita, K. Hattori, H. Yamamoto, J. Ishida, Y. Kido, K. Kamijo, K. Murano, H. Miyake, T. Kinoshita, M. Warizaya, M. Ohkubo, N. Matsuoka, S. Mutoh
FEBS Letters 579 1389 - 1393 2005.11
Structure of the complex of porcine pancreatic elastase with a trimacrocyclic peptide inhibitor FR901451 Reviewed
T. Kinoshita, T. Kitatani, M. Warizaya, T. Tada
Acta Cryst. F61 808 - 811 2005.08
Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism Reviewed
T. Terasaka, K. Tsuji, T. Kato, I. Nakanishi, T. Kinoshita, Y. Kato, M. Kuno, T. Inoue, K. Tanaka and K. Nakamura
J. Med. Chem. 48 4750 - 4753 2005.08
Structural basis of compound recognition by adenosine deaminase Reviewed
T. Kinoshita, I. Nakanishi, T. Terasaka, M. Kuno, N. Seki, M. Warizaya, H. Matsumura, T. Inoue, K. Takano, H. Adachi, Y. Mori, T. Fujii
Biochemistry 44 10562 - 10569 2005.08
FR177391, a new anti-hyperlipidemic agent from Serratia Reviewed
B. Sato, H. Nakajima, T. Fujita, S. Takase, S. Yoshimura, T. Kinoshita, H. Terano
J. Antibiot. 58 634 - 639 2005.06
Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method Reviewed
T. Kinoshita, R. Maruki, M. Warizaya, H. Nakajima and S. Nishimura
Acta Cryst. F61 346 - 349 2005.06
Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex Reviewed
M. Ohori, T. Kinoshita, M. Okubo, K. Sato, A. Yamazaki, H. Arakawa, S. Nishimura, N. Inamura, H. Nakajima, M. Neya, T. Fujii
Biochem. Biophys. Res. Commun. 336 357 - 363 2005.06
FR207944, an Antifungal Antibiotic from Chaetomium sp. No.217. II. Isolation and Structure Elucidation Reviewed
M. Kobayashi, S. Yoshimura, T. Kinoshita, M. Hashimoto, S. Hashimoto, S. Takase, A. Fujie, M. Hino, Y. Hori
Biosci. Biotechnol. Biochem. 69 1029 - 1032 2005.06
Solution stirring initiates nucleation and improves the quality of adenosine deaminase crystals Reviewed
H. Adachi, K. Takano, A. Niino, H. Matsumura, T. Kinoshita, M. Warizaya, Y. Mori, T. Sasaki
Acta Cryst. D61 759 - 762 2005.05
The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. No. 00144 II. Structure determination Reviewed
Y. Ohtsu, S. Yoshimura, T. Kinoshita, S. Takase, H. Nakajima
J. Antiniot. 58 479 - 482 2005.04
ヒト由来ADP-リボースポリメラーゼの立体構造解析:阻害剤結合による活性部位の構造変化 Reviewed
木下誉富
日本結晶学会誌 日本結晶学会 46 ( 6 ) 421 - 425 2004.12
Control of protein crystal nucleation and growth using stirring solution Reviewed
A. Niino, H. Adachi, K. Takano, H. Matsumura, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori and T. Sasaki
Jpn. J. Appl. Phys. 43 L1442 - L1444 2004.11
Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin Reviewed
M. Warizaya, T. Kinoshita, M. Yamaoka, T. Shibata, N. Saito, H. Nakajima and T. Fujii
Acta Cryst. D60 2019 - 2021 2004.10
Rational approaches to discovery of orally active and brain penetrable PARP inhibitors Reviewed
K. Hattori, Y. Kido, H. Yamamoto, J. Ishida, K. Kamijo, K. Murano, M. Ohkubo, T. Kinoshita, A. Iwashita, K. Mihara, S. Yamazaki, N. Matsuoka, Y. Teramura, H. Miyake
J. Med. Chem. 47 4151 - 4154 2004.08
SmI2-mediated reduction of ?,?-difluoro-?,?-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipetide isosteres Reviewed
A. Otaka, J. Watanabe, A. Yukimasa, Y. Sasaki, H. Watanabe, T. Kinoshita, S. Oishi, H. Tamamura, N. Fujii
J. Org. Chem. 69 1634 - 1645 2004.08
Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors Reviewed
T. Terasaka, T. Kinoshita, M. Kuno, N. Seki, K. Tanaka, I. Nakanishi
J. Med. Chem. 47 3730 - 3743 2004.07
Generation of protein crystals using a solution-stirring technique Reviewed
H. Adachi, H. Matsumura, A. Niino, K. Takano, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori, T. Sasaki
Jpn. J. Appl. Phys. 43 L762 - L764 2004.07
Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors Reviewed
T. Terasaka, H. Okumura, K. Tsuji, T. Kato, I. Nakanishi, T. Kinoshita, Y. Kato, M. Kuno, N. Seki, Y. Naoe, T. Inoue, K. Tanaka, K. Nakamura
J. Med. Chem. 47 2728 - 2731 2004.06
Improving the quality of protein crystals using stirring crystallization Reviewed
H. Adachi, H. Matsumura, A. Niino, K. Takano, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori, T. Sasaki
Jpn. J. Appl. Phys. 43 L522 - L525 2004.05
Cloning, expression, purification, crystallization and preliminary diffraction analysis of human liver glyceraldehyde-3-phophate dehydrogenase Reviewed
M. Warizaya, T. Kinoshita, A. Kato, H. Nakajima, T. Fujii
Acta Cryst. D60 567 - 568 2004.05
Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase Reviewed
T. Kinoshita, I. Nakanishi, M. Warizaya, A. Iwashita, Y. Kido, K. Hattori, T. Fujii
FEBS Letters 556 43 - 46 2004.01
Cloning, expression, purification, crystallization and preliminary diffraction analysis of the C-terminal catalytic domain of human poly(ADP-ribose) polymerase Reviewed
T. Kinoshita, T. Tsutsumi, R. Maruki, M. Warizaya, Y. Ishii, T. Fujii
Acta Cryst. D60 109 - 111 2004.01
A highly potent non-nucleotide adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization Reviewed
T. Terasaka, T. Kinoshita, M. Kuno, I. Nakanishi
J. Am. Chem. Soc. 126 34 - 35 2004.01
Improving quality and harvest period of protein crystals for structure based drug design: effects of a gel and a magnetic field on bovine adenosine deaminase crystals Reviewed
T. Kinoshita, M. Ataka, M. Warizaya, M. Neya, T. Fujii
Acta Cryst. D59 1333 - 1335 2003.06
Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors Reviewed
T. Terasaka, I. Nakanishi, K. Nakamura, Y. Eikyu, T. Kinoshita, N. Nishio, A. Sato, M. Kuno, N. Seki, K. Sakane
Bioorg. Med. Chem. Lett. 13 1115 - 1118 2003.06
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase III. Structure determination Reviewed
H. Mori, Y. Urano, T. Kinoshita, S. Yoshimura, S. Takase, M. Hino
J. Antibiot. 56 181 - 185 2003.02
Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside Reviewed
T. Kinoshita, N. Nishio, I. Nakanishi, A. Sato, T. Fujii
Acta Cryst. D59 299 - 303 2003.02
True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor Reviewed
T. Kinoshita, I. Nakanishi, A. Sato, T. Tada
Bioorg. Med. Chem. Lett. 13 21 - 24 2003.01
Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-Sn2' reactions Reviewed
A. Otaka, F. Katagiri, T. Kinoshita, Y. Odagaki, O. Shinya, H. Tamamura, N. Hamanaka N. Fuji
J. Org. Chem. 67 6152 - 6161 2002.10
Enantiometric recognition of amino acids using a chiral spiropyran derivative Reviewed
K. Tsubaki, K. Mukoyoshi, H. Morikawa, T. Kinoshita, K. Fuji
Chirality 14 713 - 715 2002.06
Use of meso-ternaphthalene derivatives: linear recognition of the ?,?-diamines by homoditopic receptors. Synthesis of the proton-ionizable lariat crown ether and chiral recognition of primary amines Reviewed
K. Tsubaki, H. Tanaka, T. Furuta, K. Tanaka, T. Kinoshita, K. Fuji
Tetrahedron 58 5611 - 5617 2002.06
The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat Reviewed
T. Kinoshita, H. Miyake, T. Fujii, S. Takakura, T. Goto
Acta Cryst. D58 622 - 626 2002.04
Synthesis of the proton-ionizable lariat crown ether and chiral recognition of primary amines Reviewed
K. Tsubaki, H. Tanaka, T. Kinoshita, K. Fuji
Tetrahedron 58 1679 - 1684 2002.02
Crystallization and preliminary X-ray diffraction studies of catalase-peroxidase from Synechococcus PCC 7942 Reviewed
K. Wada, T. Tada, Y. Nakamura, T. Kinoshita, M. Tamoi, S. Shigeoka, K.Nishimura
Acta Cryst. D58 157 - 159 2002.01
Synthesis, structure, and ion-binding properties of new tetraoxacalix[3]arenes Reviewed
K. Tsubaki, T. Morimoto, T. Otsubo, T. Kinoshita, K. Fuji
J. Org. Chem. 66 4083 - 4086 2001.11
Crystallization and preliminary X-ray diffraction analysis of NADP-dependent glyceraldehide-3-dehydrogenase of Synechococcus PCC 7942 Reviewed
Y. Nakamura, T. Tada, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka, K. Nishimura
Acta Cryst. D57 879 - 881 2001.06
The first example for cycloenatiomeric hexahomooxacalix[3]arenes Reviewed
K. Tsubaki, T. Otsubo, T. Kinoshita, M. Kawada, K. Fuji
Chem. Pharm. Bull. 49 507 - 509 2001.04
Purification, crystallization and preliminary X-ray diffraction analysis of the fructose-1,6/sedoheptulose-1,7-bisphosphatase of Synechococcus PCC 7942 Reviewed
Y. Nakamura, T. Tada, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka, K. Nishimura
Acta Cryst. D57 454 - 456 2001.03
Memory of chirality in diastereoselective α-alkylation of isoleucine and allo-isoleucine derivatives Reviewed
T. Kawabata, J. Chen, H. Suzuki, Y. Nagae, T. Kinoshita, S.Chancharunee, K. Fuji
Org. Lett. 2 3883 - 3885 2000.10
Recognition of the chain length of ?,?-diamines by a meso-ternaphthalene derivative with two crown ethers Reviewed
K. Tsubaki, H. Tanaka, T. Furuta, T. Kinoshita, K. Fuji
Tetrahedron Lett. 41 6089 - 6093 2000.08
Stereoselective synthesis of CF2-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures Reviewed
A. Otaka, E. Mitsuyama, T. Kinoshita, H. Tamamura, N. Fujii
J. Org. Chem. 65 4888 - 4899 2000.06
A new antimitotic substance, FR182877 Reviewed
S. Yoshimura, B. Sato, T. Kinoshita, S. Takase, H. Terano
J. Antibiot. 53 615 - 622 2000.05
Crystallization and preliminary X-ray analysis of cephalosporin C acylase from Pseudomonas sp. strain N176 Reviewed
T. Kinoshita, T. Tada, Y. Saito, Y. Ishii, A. Sato, M. Murata
Acta Cryst. D56 458 - 459 2000.04
Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 ? resolution Reviewed
I. Nakanishi, T. Kinoshita, A. Sato, T. Tada
Biopolymers 53 434 - 445 2000.03
Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419 Reviewed
S. Tabuchi, H. Ito, H. Sogabe, M. Kuno, T. Kinoshita, I. Katumi, N. Yamamoto, H. Mitsui, Y. Satoh
Chem. Pharm. Bull. 48 1 - 15 2000.01
The supramolecular structure of 1,4-bis(9-fluorenyl)-1,4-dihydro[60]fullerene with hexahomotrioxacalix[3]arene in the solid state Reviewed
The supramolecular structure of 1,4-bis(9-fluorenyl)-1,4-dihydro[60]fullerene with hexahomotrioxacalix[3]arene in the solid state
Hetrocycles 51 2553 - 2556 1999.12
Crystallization and preliminary analysis of bovine adenosine deaminase Reviewed
T. Kinoshita, N. Nishio, A. Sato, M. Murata
Acta Cryst. D55 2031 - 2032 1999.12
Visualization of molecular length of ?,?-diamines and temperature by a receptor based on phenolphthalein and crown ether Reviewed
K. Fuji, K. Tsubaki, K. Tanaka, N. Hayashi, T. Otsubo, T. Kinoshita
J. Am. Chem. Soc. 121 3807 - 3808 1999.10
Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons/isomerization reaction Reviewed
S. Kuroda, A. Akahane, H. Itani, S. Nishimura, K. Durkin, T. Kinoshita, K. Sakane
Tetrahedron 55 10351 - 10364 1999.08
Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation Reviewed
I. Nakanishi, T. Kinoshita, T. Tada, T. Fujita, H. Hatanaka, A. Sato
9 2397 - 2402 1999.06
Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist Reviewed
S. Kuroda, A. Akahane, H. Itani, S. Nishimura, K. Durkin, T. Kinoshita, Y. Tenda, K. Sakane
Bioorg. Med. Chem. Lett. 9 1979 - 1984 1999.04
Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5alfa]pyridin-3-yl)-1(6H)-pyridazine-butanoic acid (FK838) : A novel non-xanthine adenosine A1 receptor antagonist with potent diruretic activity Reviewed
A. Akahane, H. Katayama, T. Mitsunaga, T. Kato, T. Kinoshita, Y. Kita, T. Kusunoki T. Terai, K. Yoshida, Y. Shiokawa
J. Med. Chem. 42 779 - 783 1999.04
Complexation of C60 with hexahomooxacalix[3]arenes and supramolecular structures of complexes in the solid state Reviewed
K. Tsubaki, K. Tanaka, T. Kinoshita, K. Fuji
Chem. Commun. 895 - 896 1998.12
Palladium-catalyzed asymmetric reduction of allylic esters with a new chiral monodentate ligand, 8-diphenylphosphino-8'-mothoxy-1,1'-binaphthyl Reviewed
K. Fuji, M. Sakurai, T. Kinoshita, T. Kawabata
Tetrahedron Lett. 39 6323 - 6326 1998.12
Stepwise construction of some hexahomooxacalix[3]arenes and their comformations in solid state Reviewed
K. Tsubaki, T. Otsubo, K. Tanaka, K. Fuji, T. Kinoshita
J. Org. Chem. 63 3260 - 3265 1998.05
The first synthesis of an optically active molecular bevel gear with only two cogs on each wheel Reviewed
The first synthesis of an optically active molecular bevel gear with only two cogs on each wheel
Tetrahedron Lett. 39 1373 - 1376 1998.03
Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA: cholesterol O-acyltransferase (ACAT) bearing a pyrazol ring Reviewed
A. Tanaka, T. Terasawa, H. Hagihara, T. Kinoshita, Y. Sakuma, N. Ishibe, M. Sawada, H. Takasugi, H. Tanaka
Bioorg. Med. Chem. Lett. 8 81 - 86 1998.01
Assessment of the activity of 8-diphenylphoosphosphino-8'-mothoxy-1,1'-binaphthyl as a ligand for palladium-catalyzed reactions Reviewed
K. Fuji, M. Sakurai, T. Kinoshita, T. Tada, A. Kuroda, T. Kawabata
Chem. Pharm. Bull. 45 1524 - 1526 1997.10
Structure of the zinc endoprotease from Streptomyces caespitosus Reviewed
G. Kurisu, T. Kinoshita, A. Sugimoto, A. Nagara, Y. Kai, N. Kasai, S. Harada
J. Biochem. 121 304 - 308 1997.02
Unexpectically facile racemization of 8-diphenylphosphinoyl-8'-methoxy-1.1'-binaphthyl Reviewed
K. Fuji, M. Sakurai, N. Tohkai, A. Kuroda, T. Kawabata, Y. Fukazawa, T. Kinoshita, T. Tada
Chem. Commun. 1609 - 1610 1996.12
A novel [3+2] annulation: synthesis and X-ray crystallographic structure of a novel tetrahydropyrazolo[1,5-a]quinoline, an intermediate towards new tricyclic quinolone antibacterials Reviewed
D. Barrett, H. Sasaki, T. Kinoshita, K. Sakane
Chem. Commun. 61 - 62 1996.12
A novel synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged DNA gyrase inhibitors via a novel tandem 1,4-conjugate addition-Michael [3+2] annulation process Reviewed
D. Barrett, H. Sasaki, T. Kinoshita, A. Fujikawa, K. Sakane
Tetrahedron 52 8471 - 8488 1996.10
Alkylation of 1-[N-(hydroxymethyl)-N-methylamino]-4-quinolones. An improved preparation of intermediates for novel potent tricyclic quinolone antibacterial agents Reviewed
D. Barrett, H. Sasaki, H. Tsutsumi, T. Kinoshita, K. Sakane
Bull. Chem. Soc. Jpn 69 1371 - 1376 1996.09
Studies on Cerebral Protective Agents. X. Synthesis and evaluation of anticonvulsant activities for novel 4,5,6,7-tetrahydrothieno[3,3-c]pyridines and related compounds Reviewed
M. Ohkubo, A. Kuno, K. Katsuta, Y. Ueda, K. Shirakawa, H. Nakanishi, T. Kinoshita, H. Takasugi
Chem. Pharm. Bull. 44 778 - 784 1996.06
Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-Methyl-D-aspartate antagonists Reviewed
M. Ohkubo, A. Kuno, K. Kathuta, Y. Ueda, K. Shirakawa, H. Nakanishi, I. Nakanishi, T. Kinoshita, H. Takasugi
Chem. Pharm. Bull. 44 95 - 102 1996.01
Synthesis of new 1,8-bridged tricyclic quinolones by a novel intramolecular arylation of N-1 tethered malonamides Reviewed
D. Barrett, H. Tsutsumi, T. Kinoshita, M. Murata, K. Sakan
Tetrahedron 51 11125 - 11140 1995.10
Asymmetric synthesis of FR165914: a novel ?3-adrenergic agonist with a benzocycloheptane structure Reviewed
K. Hattori, M. Nagano, T. Kato, I. Nakanishi, K. Imai, T. Kinoshita, K. Sakane
Bioorg. Med. Chem. Lett. 5 2821 - 2823 1995.06
Complete amino acid sequence of a zinc matalloendoprotease from Streptomyces caespitosus Reviewed
S. Harada, T. Kinoshita, N. Kasai, S., Tsunasawa, F. Sakiyama
Eur. J. Biochem. 233 683 - 686 1995.04
Studies on a novel, potent and orally effective cheolecytokinin. An antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds Reviewed
Y. Sato, T. Matsuo, H. Sogabe, H. Itoh, T. Tada, T. Kinoshita, K. Yoshida, T. Takaya
Chem. Pharm. Bull. 42 2071 - 2083 1994.06
Crystallization and main-chain structure of neutral protease from Streptomyces caespitosus Reviewed
S. Harada, K.Kitadokoro, T. Kinoshita, Y. Kai, N.Kasai
J. Biochem. 110 46 - 49 1991.01
Protein allostery in drug design
Takayoshi Kinoshita( Role: Joint author)
Springer-Nature 2019.07
バイオサイエンス実験 入門から応用へ
木下誉富( Role: Joint author)
大阪府立大学共同出版会 2016.03
次世代がん戦略研究 update がん基礎生物学 革新的シーズ育成に向けて
足立恵理、酒井克也、木下誉富、松本邦夫( Role: Joint author)
南山堂 2013.10
タンパク質結晶の新展開-新しい育成技術から構造解析・応用研究へ-<普及版>
木下誉富( Role: Joint author)
シーエムシー出版 2013.10
社会との垣根を超える大学の挑戦
藤井郁雄、円谷健、藤原大佑、多田俊治、木下誉富、恩田真紀、切畑光統、谷森紳治、神川憲、乾隆( Role: Joint author)
(株)エヌ・ティー・エス 2011.12
創薬研究のストラテジー
木下誉富( Role: Joint author)
金芳堂 2011.03
コンピューターで薬を創ろう
木下誉富、仲西功( Role: Joint author)
ケイ・ディーネオブック 2009.06
タンパク質結晶の新展開-新しい育成技術から構造解析・応用研究へ-
木下誉富( Role: Joint author)
シーエムシー出版 2008.05
ポスト抗体医薬:Deep Mutational Scanning による高親和性Helix-Loop-Helix ペプチドの創出 Domestic conference
道上 雅孝、金田 有加、Chang Iou Ven、大島 綾菜、山口 亜佐子、木下 誉富、広川 貴次、藤井 郁雄
日本薬学会第145年会 2025.03 日本薬学会
フラグメント分子軌道法を用いたスタウロスポリンの結合特異性の評価 Domestic conference
御幡瑠璃、東野理子、北野真有、宮川柊兵、田雨時、高谷大輔、木下誉富、田中成典、福澤薫
日本薬学会第145年会 2025.03 日本薬学会
低毒性新規殺虫剤の開発を目指した昆虫由来CK2αのX線結晶構造解析 Domestic conference
川端新悟、池田朝香、木下誉富
BioMedical Forum 2025 2024.12
cMet 活性制御ペプチドの作用メカニズム Domestic conference
中條珠海、田中友輝、津村開、松本那夫、木下誉富
BioMedical Forum 2025 2024.12
MAP2K4/STU 複合体の X 線結晶構造解析 Domestic conference
北野真有、祐村清悟、馬場健吉、澤匡明、木下誉富
BioMedical Forum 2025 2024.12
MAP2K2, MAP2K3, MAP2K5の自己阻害機構の解明 Domestic conference
松下葵、村川優花、中野可鈴、北村莉奈、中田海斗、木下誉富
BioMedical Forum 2025 2024.12
S100-A8/A9阻害剤の作用メカニズムの解明 Domestic conference
松下葵、竹野有香、田中那美、岡邑舞子、池川雅哉、木下誉富
令和6年度日本結晶学会年会 2024.11 日本結晶学会
MAP2Kファミリーのstaurosporine複合体のX線結晶構造解析 Domestic conference
北野真有、祐村清悟、澤匡明、木下誉富
令和6年度日本結晶学会年会 2024.11 日本結晶学会
MAP2K6選択的阻害剤の創出に必須となる構造知見 Domestic conference
祐村清悟、森次圭、北川大輔、澤匡明、木下誉富
令和6年度日本結晶学会年会 2024.11 日本結晶学会
FRK-キナーゼドメイン/staurosporine複合体のX線結晶構造解析 Domestic conference
川端凌弥、中井良子、澤匡明、木下誉富
令和6年度日本結晶学会年会 2024.11 日本結晶学会
Dynamical interaction energy analysis of eastase in each reaction state: insights from molecular dynamics and fragment molecular orbital calculations Domestic conference
2024.10
Investigation of the allosteric binding sites of ERK2 by metadynamics simulation Domestic conference
2024.10
Analysis of kinase binding specificity of staurosporine using the fragment molecular orbital method Domestic conference
2024.10
キナーゼの構造生物学と創薬研究 Invited Domestic conference
木下誉富
日本結晶学会Keynotes 2024.10 日本結晶学会
Protein kinase CK2阻害活性を有するプリン誘導体の構造活性相関研究—プリン環2位への種々の飽和炭化水素置換基の導入— Domestic conference
中谷汐里、中川愛理、吉岡賢司、西脇敬二、中村真也、露口正人、木下誉富、仲西功
日本薬学会第144年会 2024.03 日本薬学会
クライオ電子顕微鏡を用いたMAP2K6-p38αMAPK複合体の構造研究 Domestic conference
川端凌弥、宮園真吾、木下誉富
BioMedical Forum 2024 2023.12 大阪公立大学研究推進機構
In-crystal化合物交換法によるMAP2K4-阻害剤複合体結晶の調製 Domestic conference
山下直之、祐村清悟、木下誉富
BioMedical Forum 2024 2023.12 大阪公立大学研究推進機構
プロテインキナーゼCK2αの結晶水を考慮した阻害剤の設計と合成および活性評価 Domestic conference
西脇敬二、中谷汐里、中村真也、吉岡賢司、中川愛理、露口正人、木下誉富、仲西功
40回メディシナルケミストリーシンポジウム 2023.11 日本薬学会医薬化学部会
Intact and phosphorylated peptides derived from the N- and C-terminal regions enhance and inhibit cMet kinase activity, respectively Domestic conference
2023.11
Mechanism-based Discovery of peptide inhibitors of FGFR3/G697C, a pathogenic active mutant Domestic conference
2023.11
p38αMAPK による基質Smad3の認識機構の解明 Domestic conference
長谷川誠将、永尾春菜、澤匡明、木下誉富
令和5年度日本結晶学会年会 2023.10 日本結晶学会
In-crystal 交換法によるMAP2K4-阻害剤複合体結晶の調製 Domestic conference
山下直之、祐村清悟、木下誉富
令和5年度日本結晶学会年会 2023.10
MAXS reveals a disorder-to-order transition of the intrinsically disordered region in active MAP2K6 Domestic conference
2023.10
Insight into the Binding Modes of Allosteric ERK2 Inhibitors using Metadynamics Simulations Domestic conference
2023.10
Conserved gatekeeper methionine determines the accessibility to the ATP-sites and selectivity among MAP2K1/4/7 Domestic conference
2023.10
Steps forward beyond the crystal structures: MAXS reveals the potential massive movements during the catalytic action of a kinase International conference
T. Matsumoto, A. Yamano, Y. Murakawa, H. Fukada, M. Sawa, T. Kinoshita
26th Congress and General Assembly of the International Union of Crystallography IUCr2023 2023.08 International Union of Crystallography
MAP2K4-阻害剤複合体のX線結晶構造-共有結合できない共有結合性阻害剤- Domestic conference
祐村清悟、山下直之、北川大輔、澤匡明、木下誉富
第23回日本蛋白質科学会年会 2023.07 日本蛋白質科学会
Protein Kinase CK2阻害活性を有するプリン誘導体の構造活性相関研究―結合ポケット奥の結晶水を残すCK2阻害剤設計― Domestic conference
中谷汐里、中川愛理、吉岡賢司、西脇敬二、中村真也、露口正人、木下誉富、仲西功
日本薬学会第143年会 2023.03 日本薬学会
アミノピラゾール系阻害剤の二つの結合様式が示すCK2α1選択的阻害剤への手掛かり Domestic conference
露口正人、池田朝香、北川大輔、澤匡明、中村真也、仲西功、木下誉富
2022年度量子ビームサイエンスフェスタ(第14回MLFシンポジウム/第40回PFシンポジウム) 2023.03
MAP2K4/5Z7-oxozeaenol複合体のX線結晶構造解析 Domestic conference
祐村清悟、山下直之、木下誉富
BioMedical Forum 2023 2023.01
二価性阻害剤の結合様式が示す特異的CK2α1阻害剤の創出基盤 Domestic conference
池田朝香、露口正人、北川大輔、澤匡明、中村真也、西脇敬二、仲西功、木下誉富
BioMedical Forum 2023 2023.01
高選択性p38α阻害剤創出に向けた構造基盤 Domestic conference
長谷川誠将、吉田茉由、杉山肇、木下誉富
BioMedical Forum 2023 2023.01
MAP2K4-共有結合性阻害剤のX線結晶構造解析 Domestic conference
祐村清悟、山下直之、木下誉富
令和4年度日本結晶学会年会 2022.10 日本結晶学会
セリン・スレオニンキナーゼMosの活性制御機構の解明 Domestic conference
馬場健吉、木下誉富
令和4年度日本結晶学会年会 2022.10 日本結晶学会
FGFR3/G697Cの触媒機構の解明に向けた構造生物学研究 Domestic conference
鈴木大輔、木下誉富
令和4年度日本結晶学会年会 2022.10 日本結晶学会
MAP2K4阻害剤の相互作用様式の解明 Domestic conference
山下直之、祐村清悟、木下誉富
令和4年度日本結晶学会年会 2022.10 日本結晶学会
高選択性MAPキナーゼ阻害剤創出に向けた構造基盤 Domestic conference
長谷川誠将、吉田茉由、杉山肇、木下誉富
令和4年度日本結晶学会年会 2022.10 日本結晶学会
昆虫由来のプロテインキナーゼの構造生物学的研究 Domestic conference
池田朝香、井戸邦夫、木下誉富
令和4年度日本結晶学会年会 2022.10 日本結晶学会
Insight into Allosteric ERK2 Inhibitors by using Metadynamics Simulations Domestic conference
2022.10
Protein Kinase CK2阻害活性を有するプリン誘導体の構造活性相関研究―環式飽和炭化水素置換基の導入― Domestic conference
中谷汐里、西脇敬二、中村真也、露口正人、木下誉富、仲西功
第72回日本薬学会関西支部大会 2022.10 日本薬学会関西支部
MAXS reveals the conformational changes of intrinsically disordered region of MAP2K6 International conference
T. Matsumoto, S. Hasegawa, T. Hasegawa, T. Kinoshita
33th European Crystallographic Meeting 2022.08 European Crystallographic Association
MAXSを活用した蛋白質の構造変化と機能の関係に基づく創薬戦略
松本 崇, 山野 昭人, 村川 優花, 深田 はるみ, 澤 匡明, 木下 誉富
日本農薬学会大会講演要旨集 2022.03 日本農薬学会
インシリコスクリーニングから得たアロステリック阻害剤の選択性に関する考察 Domestic conference
吉田茉由、杉山肇、永尾春菜、澤匡明、木下誉富
第49回構造活性相関シンポジウム 2021.11 日本薬学会
CK2a1選択性向上に向けたアロステリック部位の構造知見 Domestic conference
池田朝香、露口正人、中村真也、西脇敬二、仲西功、木下誉富
第49回構造活性相関シンポジウム 2021.11 日本薬学会
高選択性MAP2K阻害剤の開発に向けた構造基盤の構築 Domestic conference
祐村清悟、木下誉富
令和3年(2021年)度日本結晶学会年会 2021.11 日本結晶学会
MAP2K3の非twin結晶の取得に向けた結晶化検討 Domestic conference
中野可鈴、村川優花、木下誉富
令和3年(2021年)度日本結晶学会年会 2021.11 日本結晶学会
構造生物学を基盤としたキナーゼ創薬研究 Invited Domestic conference
木下誉富
第35回農薬デザイン研究会 2021.11 日本農薬学会
Evaluation of the peptide derived from the N- and C-terminal regions of kinase domain for allosteric control of receptor tyrosine kinase cMet Domestic conference
田中友輝、松本邦夫、木下誉富
第58回ペプチド討論会 2021.10 日本ペプチド学会
Molecular basis of allosteric ERK2 inhibitors discovered by in silico screening Domestic conference
吉田茉由、杉山肇、永尾春菜、澤匡明、木下誉富
CBI学会2021年大会 2021.10 CBI学会
Insight into allosteric ERK2 inhibitors by using fragment molecular orbital method Domestic conference
杉山肇、吉田茉由、木下誉富
CBI学会2021年大会 2021.10 CBI学会
中性子線結晶構造解析とMDシミュレーションを駆使した酵素反応の理解 Invited Domestic conference
木下誉富
CBI学会2021年大会スポンサーセッション新世代中性子構造生物学研究会 2021.10 CBI学会
高選択的CK2a1阻害剤の創出を目指したニトリル系化合物の阻害機構の解明 Domestic conference
池田朝香、露口正人、中村真也、西脇敬二、仲西功、木下誉富
第21回日本蛋白質科学会年会 2021.06 日本蛋白質科学会
KIMサイト結合型ERK2キナーゼ阻害剤の作用機序の解明 Domestic conference
吉田茉由、森悠里花、永尾春菜、澤匡明、木下誉富
第21回日本蛋白質科学会年会 2021.06 日本蛋白質科学会
プリン骨格を有するCK2阻害剤の構造活性相関研究 プリン骨格の互変異性の検討
河津 有貴, 中川 愛理, 吉岡 賢司, 中村 真也, 西脇 敬二, 露口 正人, 木下 誉富, 仲西 功
日本薬学会年会要旨集 2020.03 (公社)日本薬学会
キナーゼの生化学実験
キナーゼのX線結晶構造解析
生物化学実験2
2024 Weekly class Undergraduate
構造生物学
2024 Weekly class Undergraduate
基礎物理化学
2024 Weekly class Undergraduate
基礎物理化学
2024 Weekly class Undergraduate
生物化学特別講義D
2024 Intensive lecture Graduate school
構造生物学特論
2024 Weekly class Graduate school
生物化学特別研究2A
2024 Intensive lecture Graduate school
生物化学特別研究1A
2024 Intensive lecture Graduate school
生物化学特別演習2A
2024 Intensive lecture Graduate school
生物化学特別演習1A
2024 Intensive lecture Graduate school
生物化学特別講義H
2024 Intensive lecture Graduate school
生物化学特別研究5A
2024 Intensive lecture Graduate school
生物化学特別研究4A
2024 Intensive lecture Graduate school
生物化学特別研究3A
2024 Intensive lecture Graduate school
生物化学特別演習5A
2024 Intensive lecture Graduate school
生物化学特別演習4A
2024 Intensive lecture Graduate school
生物化学特別演習3A
2024 Intensive lecture Graduate school
構造生物学
2024 Weekly class Undergraduate
基礎物理化学
2024 Weekly class Undergraduate
創薬科学実習2
2024 Intensive lecture Undergraduate
創薬科学実習1
2024 Intensive lecture Undergraduate
創薬科学のすすめ
2024 Weekly class Graduate school
創薬科学のすすめ
2024 Weekly class Graduate school
生物化学への招待
2024 Weekly class Graduate school
生物化学基礎演習
2024 Intensive lecture Undergraduate
生物化学実験3
2024 Intensive lecture Undergraduate
生物化学実験1
2024 Weekly class Undergraduate
ケミカルバイオロジー概論
2024 Weekly class Undergraduate
生化学2
2024 Weekly class Undergraduate
生物化学概論
2024 Weekly class Undergraduate
サイエンスフロンティアB(生物化学)
2024 Intensive lecture Graduate school
サイエンスフロンティアA(生物化学)
2024 Intensive lecture Graduate school
海外特別研究1
2024 Intensive lecture Graduate school
生物化学特別研究2B
2024 Intensive lecture Graduate school
生物化学特別研究1B
2024 Intensive lecture Graduate school
生物化学特別演習2B
2024 Intensive lecture Graduate school
生物化学特別演習1B
2024 Intensive lecture Graduate school
研究企画ゼミナール1
2024 Intensive lecture Graduate school
研究企画ゼミナール1
2024 Intensive lecture Graduate school
海外特別研究2
2024 Intensive lecture Graduate school
海外特別研究2
2024 Intensive lecture Graduate school
生物化学特別研究5B
2024 Intensive lecture Graduate school
生物化学特別研究4B
2024 Intensive lecture Graduate school
生物化学特別研究3B
2024 Intensive lecture Graduate school
生物化学特別演習5B
2024 Intensive lecture Graduate school
生物化学特別演習4B
2024 Intensive lecture Graduate school
生物化学特別演習3B
2024 Intensive lecture Graduate school
研究企画ゼミナール2
2024 Intensive lecture Graduate school
研究企画ゼミナール2
2024 Intensive lecture Graduate school
研究企画ゼミナール2
2024 Intensive lecture Graduate school
研究企画ゼミナール2
2024 Intensive lecture Graduate school
研究企画ゼミナール1
2023 Intensive lecture Graduate school
創薬科学のすすめ
2023 Weekly class Graduate school
生物化学への招待
2023 Weekly class Graduate school
生物化学特別研究4A
2023 Intensive lecture Graduate school
生物化学特別研究3A
2023 Intensive lecture Graduate school
生物化学特別演習4A
2023 Intensive lecture Graduate school
生物化学特別演習3A
2023 Intensive lecture Graduate school
研究企画ゼミナール2
2023 Intensive lecture Graduate school
構造生物学特論
2023 Weekly class Graduate school
生物化学特別研究2A
2023 Intensive lecture Graduate school
生物化学特別研究1A
2023 Intensive lecture Graduate school
生物化学特別演習2A
2023 Intensive lecture Graduate school
生物化学特別演習1A
2023 Intensive lecture Graduate school
研究企画ゼミナール1
2023 Intensive lecture Graduate school
創薬科学実習II
2023 Intensive lecture Undergraduate
創薬科学実習I
2023 Intensive lecture Undergraduate
構造生物学
2023 Weekly class Undergraduate
基礎物理化学
2023 Weekly class Undergraduate
生物科学実験II
2023 Weekly class Undergraduate
生物化学実験1
2023 Weekly class Undergraduate
生化学2
2023 Weekly class Undergraduate
生物化学概論
2023 Weekly class Undergraduate
生物系機器分析学
2023 Weekly class Undergraduate
生物化学特別研究4B
2023 Intensive lecture Graduate school
生物化学特別研究3B
2023 Intensive lecture Graduate school
生物化学特別演習4B
2023 Intensive lecture Graduate school
生物化学特別演習3B
2023 Intensive lecture Graduate school
研究企画ゼミナール2
2023 Intensive lecture Graduate school
生物化学特別研究2B
2023 Intensive lecture Graduate school
生物化学特別研究1B
2023 Intensive lecture Graduate school
生物化学特別演習2B
2023 Intensive lecture Graduate school
生物化学特別演習1B
2023 Intensive lecture Graduate school
Laboratory Training in Drug Discovery Sciences & Technology II
2021 Practical Training
Laboratory Training in Drug Discovery Sciences & Technology I
2021 Practical Training
Experiment in Biological Science II
2021 Practical Training
Instrumental Analysis in Biology
2021
Introduction of Drug Discovery
2021
English for Scientists
2021
Structural Biology
2021
Fundamental Physical Chemistry
2021
Structural Biology
2021
2024
Number of undergraduate student / college student presentations:7 Number of graduate students presentations:5
2023
Number of undergraduate student / college student presentations:0 Number of graduate students presentations:3
2024
Number of instructed the graduation thesis:3 Number of graduation thesis reviews:3
[Number of instructed the Master's Program] (previous term):5 [Number of instructed the Master's Program] (letter term):1
[Number of master's thesis reviews] (chief):7 [Number of master's thesis reviews] (vice-chief):5
[Number of doctoral thesis reviews] (chief):0 [Number of doctoral thesis reviews] (vice-chief):1
2023
Number of instructed the graduation thesis:3 Number of graduation thesis reviews:3
[Number of instructed the Master's Program] (previous term):5 [Number of instructed the Master's Program] (letter term):1
[Number of master's thesis reviews] (chief):3 [Number of master's thesis reviews] (vice-chief):5
[Number of doctoral thesis reviews] (chief):0 [Number of doctoral thesis reviews] (vice-chief):1
2022
Number of instructed the graduation thesis:4 Number of graduation thesis reviews:4
[Number of instructed the Master's Program] (previous term):5 [Number of instructed the Master's Program] (letter term):1
[Number of master's thesis reviews] (chief):3 [Number of master's thesis reviews] (vice-chief):6
2021
Number of instructed the graduation thesis:3 Number of graduation thesis reviews:3
[Number of instructed the Master's Program] (previous term):5
[Number of master's thesis reviews] (chief):2 [Number of master's thesis reviews] (vice-chief):4
[Number of doctoral thesis reviews] (vice-chief):3
2020
Number of instructed the graduation thesis:3
2019
Number of instructed the graduation thesis:2
2024
Original item:リゾーム型研究人材育成プログラム 副指導教員 (医学研究科・薩仁 朝格吐さん)
Special report:資格審査 2回
2023
Original item:リゾーム型研究人材育成プログラム 副指導教員 (医学研究科・薩仁 朝格吐さん)
Special report:資格審査 2回
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2025.03
International Journal of Peptide Research and Therapeutics
Role(s): Peer review
2025.02
Computers in Biology and Medicine
Role(s): Peer review
2025.01
International Journal of Biological Macromolecules
Role(s): Peer review
2025.01
European Journal of Medicinal Chemistry
Role(s): Peer review
2024.12 - 2025.01
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2024.11
European Journal of Medicinal Chemistry
Role(s): Peer review
2024.11
Biochemical Pharmacology
Role(s): Peer review
2024.09
European Journal of Medicinal Chemistry
Role(s): Peer review
2024.09
Computers in Biology and Medicine
Role(s): Peer review
2024.08
ACS Bio & Chem Au
Role(s): Peer review
2024.07
Biophysical Chemistry
Role(s): Peer review
2024.07
Computational Biology and Chemistry
Role(s): Peer review
2024.07
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2024.06
European Journal of Medicinal Chemistry
Role(s): Peer review
2024.06
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2024.04
European Journal of Medicinal Chemistry
Role(s): Peer review
2024.02
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2024.02
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2024.01
Bioorganic Chemistry
Role(s): Peer review
2023.12
Heliyon
Role(s): Peer review
2023.11
European Journal of Medicinal Chemistry
Role(s): Peer review
2023.09
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2023.07
Bioorganic and Medicinal Chemistry Letters
Role(s): Peer review
2023.07
European Journal of Medicinal Chemistry
Role(s): Peer review
2023.05
Acta Crystallographica Section D
Role(s): Peer review
2023.05
2024
SDGs:
Original item:量子科学研究開発機構 客員研究員
2023
SDGs:
Original item:量子科学研究開発機構 客員研究員
2023
SDGs:
Original item:兵庫県立尼崎小田高等学校「大阪公立大学研修」講師
2024
International Students :1
2023
International Students :1