日本薬学会

1994.04 - Now   Domestic

日本結晶学会

1994.04 - Now   Domestic

Ensemble structural analyses depict the regulatory mechanism of non-phosphorylated human MAP2K4 Reviewed

T. Matsumoto, A. Yamano, Y. Murakawa, H. Fukada, M. Sawa, T. Kinoshita

Biochem. Biophys. Res. Commun. 雑誌   521   106 - 112   2020.01

An isoform-selective inhibitor of tropomyosin receptor kinase A behaves as molecular glue Reviewed

N. Furuya, T. Momose, K. Katsuno, N. Fushimi, H. Muranaka, C. Handa, M. Sawa, T. Ozawa, T. Kinoshita

Bioorg. Med. Chem. Lett. 雑誌   30   2020.01

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Tsuyoshi Oshima, Yoshimi Niwa, Keiko Kuwata, Ashutosh Srivastava, Tomoko Hyoda, Yoshiki Tsuchiya, Megumi Kumagai, Masato Tsuyuguchi, Teruya Tamaru, Akiko Sugiyama, Natsuko Ono, Norjin Zolboot, Yoshiki Aikawa, Shunsuke Oishi, Atsushi Nonami, Fumio Arai, Shinya Hagihara, Junichiro Yamaguchi, Florence Tama, Yuya Kunisaki, Kazuhiro Yagita, Masaaki Ikeda, Takayoshi Kinoshita, Steve A. Kay, Kenichiro Itami, Tsuyoshi Hirota

Science Advances   5 ( 1 )   2019.01

Covalent docking identifies a potent and selective MKK7 inhibitor Reviewed

A. Shraga, E. Olhavang, N. Davidzohn, P. Khoshkenar, N. Germain, K. Shurrush, S. Carvalho, L. Avram, S. Albeck, T. Unger, B. Lefker, C. Subramanyam, R.H. Hudkins, A. Mitchell, Z. Shulman, T. Kinoshita, N. London

Cell Chem. Biol. 雑誌   26   98 - 108   2019.01

A microgravity environment improves structural resolution and endows cues for specific inhibition of mitogen-activated protein kinase kinase 7 Reviewed

T. Kinoshita, T. Hashimoto, Y. Murakawa, Y. Sogabe, T. Matsumoto, M. Sawa

Int. J. Microgravity Sci. Appl. 雑誌   36   2019.01

A promiscuous kinase inhibitor delineates the conspicuous structural features of protein kinase CK2a1

Masato Tsuyuguchi, Tetsuko Nakaniwa, Masaaki Sawa, Isao Nakanishi, Takayoshi Kinoshita

Acta Crystallographica Section F: Structural Biology Communications   75   515 - 519   2019

Hydration structures of the human protein kinase CK2a clarified by joint neutron and X-ray crystallography Reviewed

C. Shibasaki, S. Arai, R. Shimizu, M. Saeki, T. Kinoshita, A. Ostermann, T.E. Schrader, Y. Kurosaki, T. Sunami, R. Kuroki, M. Adachi

J. Mol. Biol. 雑誌   430   5094 - 5104   2018.07

Crystal structures of human CK2a2 in new crystal forms arising from a subtle difference in salt concentration Reviewed

M. Tsuyuguchi, T. Nakaniwa, T. Kinoshita

Acta Cryst. 雑誌   F74   288 - 293   2018.06

Foretinib overcomes entrectinib resistance associated with the NTRK1 G667C mutation in NTRK1 fusion-positive tumor cells in a brain metastasis model Reviewed

A. Nishiyama, T. Yamada, K. Kita, R. Wang, S. Arai, K. Fukuda, A. Tanimoto, S. Takeuchi, S. Tange, A. Tajima, N. Furuya, T. Kinoshita, S. Yano

Clinical Cancer Res. 雑誌   24   2357 - 2369   2018.05

High-resolution structure discloses the potential for allosteric regulation of mitogen-activated protein kinase kinase 7 Reviewed

T. Kinoshita, T. Hashimoto, Y. Sogabe, H. Fukada, T. Matsumoto, M. Sawa

Biochem. Biophys. Res. Commun. 雑誌   493   313 - 317   2017.06

The juxtamembrane region of TrkA kinase is critical for inhibitor selectivity Reviewed

N. Furuya, T. Momose, K. Katsuno, N. Fushimi, H. Muranaka, C. Handa, T. Ozawa, T. Kinoshit

Bioorg. Med. Chem. Lett. 雑誌   27   1233 - 1236   2017.01

A crucial role of Cys218 in configuring an unprecedented auto-inhibition form of MAP2K7 Reviewed

Y. Sogabe, T. Hashimoto, T. Matsumoto, Y. Kirii, M. Sawa, T. Kinoshita

Biochem. Biophys. Res. Commun. 雑誌   473   476 - 481   2016.10

Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inihibitors Reviewed

H. Ohno, D. Minamiguchi, S. Nakamura, K. Shu, S. Okazaki, M. Honda, R. Misu, H. Moriwaki, S. Nakanishi, S. Oishi, T. Kinoshita, I. Nakanishi, N. Fujii

Bioorg. Med. Chem. 雑誌   24   1136 - 1141   2016.03

Identification of allosteric ERK2 inhibitors through in silico biased screening and competitive binding assay Reviewed

T. Kinoshita, H. Sugiyama, Y. Mori, N. Takahashi, A. Tomonaga

Bioorg. Med. Chem. Lett. 雑誌   26   955 - 958   2016.02

Bioconversion of FR901459, a novel derivative of cyclosporine A, by Lenzea sp. 7887 Reviewed

S. Sasamura, M. Kobayashi, H. Muramatsu, S. Yoshimura, T. Kinoshita, H. Ohki, K. Okada, Y. Deai, Y. Yamagishi, M. Hashimoto

J. Antibiot. 雑誌   68   511 - 520   2015.07

Identification of protein kinase CK2 inhibitors using solvent dipole ordering virtual screening Reviewed

I. Nakanishi, K. Murata, N. Nagata, M. Kurono, T. Kinoshita, M. Yasue, T. Miyazaki, Y. Takei, S. Nakamura, A. Sakurai, N. Iwamoto, N. Nishiwaki, T. Nakaniwa, Y. Sekiguchi, A. Hirasawa, G. Tsujimoto, K. Kitaura

Eur. J. Med. Chem. 雑誌   96   396 - 404   2015.04

5Z-7-oxozeaenol covalently binds to MAP2K7 at Cys218 in an unprecedented manner Reviewed

Y. Sogabe, T. Matsumoto, T. Hashimoto, Y. Kirii, M. Sawa, T. Kinoshita

Bioorg. Med. Chem. Lett.   25   593 - 596   2015.01

Hepatocyte growth factor Reviewed

K. Sakai, T. Kinoshita, K. Matsumoto

References Module in Biological Sciences   2014.12

Crystal structure of human CK2a at 1,06A resolution Reviewed

T. Kinoshita, T. Nakaniwa, Y. Sekiguchi, Y. Sogabe, A. Sakurai, S. Nakamura, I. Nakanishi

J. Synchrotron Rad.   20   974 - 979   2013.12

ヒトMAPキナーゼJNK1の立体構造・機能・安定性に対する遊離システイン残基の置換効果 Reviewed

仲庭哲津子、深田はるみ、黒木良太、木下誉富

日本結晶学会誌 日本結晶学会   55   197 - 202   2013.06

Seven cysteine-deficient mutants depict interplay between thermal and chemical stabilities of individual cysteine residues in MAP kinase JNK1 Reviewed

T. Nakaniwa, H. Fukada, T. Inoue, M. Gouda, R. Nakai, Y. Kirii, M. Adachi, T. Tamada, S. Segawa, R. Kuroki, T. Tada, T. Kinoshita

Biochemistry   51   8410 - 8421   2012.10

Crystal and solution structures disclose a putative transient state of mitogen-activated kinase kinase 4 Reviewed

T. Matsumoto, T. Kinoshita, Y. Kirii, T. Tada, A. Yamano

Biochem. Biophys. Res. Commun.   425   195 - 200   2012.08

The in silico screening and X-ray structure analysis and the inhibitor complex of plasmodium falciparum orotidine-5'-monophosphate decarboxylase Reviewed

Y. Takashima, E. Mizohata, S.R. Krunkrai, Y. Fukunishi, T. Kinoshita, T. Sakata, H. Matsumra, J. Krungkrai, T. Horii, T. Inoue

J. Biochem.   152   133 - 138   2012.08

Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state Reviewed

T. Matsumoto, T. Kinoshita, H. Furukawa, R. Nakai, Y. Kirii, K. Yokota, T. Tada

J. Biochem.   151   541 - 549   2012.05

Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scafolds Reviewed

Z. Hou, I. Nakanishi, T. Kinoshita, Y. Takei, M. Yasue, R. Misu, Y. Suzuki, S. Nakamura, T. Kure, H. Ohno, K. Murata, K. Kitaura, A. Hirasawa, G. Tsujimoto, S. Oishi, N. Fujii

J. Med. Chem.   55   2899 - 2903   2012.03

Knowledge-based identification of the ERK2/STAT3 signal pathway as a therapeutic target for type 2 diabates and drug discovery Reviewed

T. Kinoshita, K. Doi, H. Sugiyama, S. Kinoshita, M. Wada, S. Naruto, T. Tomonaga

Chem. Biol. Drug Des.   78   471 - 476   2011.09

A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase Reviewed

T. Kinoshita, Y. Sekiguchi, H. Fukada, T. Nakaniwa, T. Tada, S. Nakamura, K. Kitaura, H. Ohno, Y. Suzuki, A. Hirasawa, I. Nakanishi, G. Tsujimoto

Mol. Cell. Biochem.   356   97 - 105   2011.09

HGF-antagonists: structure, activities, and anti-cancer approach Reviewed

K. Sakai, T. Nakamura, T. Kinoshita, T. Nakamura, K. Matsumoto

Current Signal Transduction Therapy   6   191 - 199   2011.05

High resolution structure of exo-arabinanase from Penicillium chrysogenum Reviewed

Y. Sogabe, T. Kitatani, A. Yamaguchi, T. Kinoshita, H. Adachi, K. Takano, T. Inoue, Y. Mori, H. Matsumura, T. Sakamoto, T. Tada

Acta Cryst.   D67   415 - 422   2011.04

Crystal structures of MKK4 kinase domain reveal that substrate peptide binds to an allosteric site and induces an auto-inhibition state Reviewed

T. Matsumoto, T. Kinoshita, Y. Kirii, K. Yokota, K. Hamada, T. Tada

Biochem. Biophys. Res. Commun.   400   369 - 373   2010.08

中性子構造解析および超高分解能Ｘ線構造解析によるエラスターゼの機能解明 Reviewed

玉田太郎、黒木良太、木下誉富、多田俊治

日本結晶学会誌 日本結晶学会   52 ( 2 )   133 - 138   2010.04

A silent mutation allows efficient production of active human Frk tyrosine kinase in Escheria coli Reviewed

X. Yang, T. Kinoshita, M. Gouda, K. Yokota, T. Tada

Biosci. Biotechnol. Biochem.   74   125 - 128   2010.02

創薬バリューチェインのインシリコ技術を活用した阻害剤開発の試み Reviewed

井上豪、松村浩由、安達宏昭、森勇介、高野和文、村上聡、福西快文、中村春木、木下誉富、仲西功、奥野恭史、南方聖司、三上義明、佐久間俊広、北島正人、福岡良忠、高田俊和、坂田恒昭

日本結晶学会誌 日本結晶学会   52 ( 1 )   89 - 94   2010.02

Structure basis for the inhibitor recognition of human Lyn kinase domain Reviewed

N. Miyano, T.Kinoshita, R. Nakai, Y. Kirii, K. Yokota, T. Tada

Bioorg. Med. Chem. Lett.   19   6557 - 6560   2009.11

Combined high-resolution neutron and X-ray analysis of inhibited elastase confirms the active-site oxyanion hole but rules against a low-barrier hydrogen bond Reviewed

T. Tamada, T. Kinoshita, K. Kurihara, M. Adachi, T. Ohhara, K. Imai, R. Kuroki, T. Tada

J. Am. Chem. Soc.   131   11033 - 11040   2009.08

Structural insight into human CK2a in complex with the potent inhibitor ellagic acid Reviewed

Y. Sekiguchi, T. Nakaniwa, T. Kinoshita, I. Nakanishi, K. Kitaura, A. Hirasawa, G. Tsujimoto, T. Tada

Bioorg. Med. Chem. Lett.   19   2920 - 2923   2009.05

Structure of human protein kinase CK2a2 with a potent indazole-derivative inhibitor Reviewed

T. Nakaniwa, T. Kinoshita, Y. Sekiguchi, T. Tada, I. Nakanishi, K. Kitaura, Y. Suzuki, H. Ohno, A. Hirasawa, G. Tsujimoto

Acta Cryst.   F65   75 - 79   2009.02

Crystal structure of human mono-phosphorylated ERK1 at Tyr204 Reviewed

T. Kinoshita, I. Yoshida, S. Nakae, K. Okita, M. Gouda, M. Matsubara, K. Yokota, H. Ishiguro, T. Tada

Biochem. Biophys. Res. Commun.   377   1123 - 1127   2008.12

Conformation change of adenosine deaminase during ligand-exchange in a crystal Reviewed

T. Kinoshita, T. Tada, I. Nakanishi

Biochem. Biophys. Res. Commun.   373   53 - 57   2008.07

Protein purification and preliminary crystallographic analysis of human Lyn tyrosine kinase Reviewed

T. Kinoshita, N. Miyano, R. Nakai, K. Yokota, H. Ishiguro, T. Tada

Protein Expr. Purif.   58   318 - 324   2008.03

Crystallization of porcine pancreatic elastase and preliminary neutron diffraction experiment Reviewed

T. Kinoshita, T. Tamada, K. Imai, K. Kurihara, T. Ohhara, T. Tada, R. Kuroki

Acta Cryst.   F63   315 - 317   2007.04

Role of a cystein residue in the active site of ERK and the MAPKK family Reviewed

M. Ohori, T. Kinoshita, S. Yoshimura, M. Warizaya, H. Nakajima, H. Miyake

Biochem. Biophys. Res. Commun.   353   633 - 637   2007.02

Structure of human Fyn kinase domain complexed with staurosporine Reviewed

T. Kinoshita, M. Matsubara, H. Ishiguro, K. Okita, T. Tada

Biochem. Biophys. Res. Commun.   346   840 - 844   2006.08

Structure of apo-glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7992 Reviewed

T. Kitatani, Y. Nakamura, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka, T. Tada

Acta Cryst.   F62   727 - 730   2006.08

Tris(hydroxymethyl)aminomethane induces conformational change and crystal-packing contraction of porcine pancreatic elastase Reviewed

T. Kinoshita, A. Yamaguchi, T. Tada

Acta Cryst.   F62   623 - 626   2006.07

Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938 Reviewed

M. Kuno, N. Seki, S. Tsujimoto, I. Nakanishi, T. Kinoshita, K. Nakamura, T. Terasaka, N. Nishio, A. Sato, T. Fujii

Eur. J. Pharmcol.   534   241 - 249   2006.04

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling Reviewed

J. Ishida, H. Yamamoto, Y. Kido, K. Kamijo, K. Murano, H. Miyake, M. Okubo, T. Kinoshita, M. Warizaya, A. Iwashita, K. Mihara, N. Matsuoka, K. Hattori

Bioorg. Med. Chem.   14   1378 - 1390   2006.03

Structure of NADP-dependent glyceraldehyde-3-phosphate dehydrogenase from Synechococcus PCC7942 complexed with NADP Reviewed

T. Kitatani, Y. Nakamura, K. Wada, T. Kinoshita, S. Shigeoka, T. Tada

Acta Cryst.   F62   315 - 319   2006.03

Crystal structure of human ERK2 complexed with a pyrazolo[3,4c]pyridazine derivative Reviewed

T. Kinoshita, M. Warizaya, M. Ohori, K. Sato, M. Neya, T. Fujii

Bioorg.Med. Chem. Lett.   16   55 - 58   2006.01

Solution-Stirring Method Improves Crystal Quality of Human Triosephosphate Isomerase Reviewed

H. Adachi, A. Niino, T. Kinoshita, M. Warizaya, R. Maruki, K. Takano, H. Matsumura, T. Inoue, S. Murakami, Y. Mori, T. Sasaki

J. Biosci. Bioeng.   101   83 - 86   2006.01

Protein Crystallization by combining laser irradiation and solution-stirring techniques Reviewed

H. Adachi, A. Niino, S. Murakami, K. Takano, H. Matsumura, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori and T. Sasaki

Jpn. J. Appl. Phys.   44   1365 - 1366   2005.12

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors Reviewed

A. Iwashita, K. Hattori, H. Yamamoto, J. Ishida, Y. Kido, K. Kamijo, K. Murano, H. Miyake, T. Kinoshita, M. Warizaya, M. Ohkubo, N. Matsuoka, S. Mutoh

FEBS Letters   579   1389 - 1393   2005.11

Structure of the complex of porcine pancreatic elastase with a trimacrocyclic peptide inhibitor FR901451 Reviewed

T. Kinoshita, T. Kitatani, M. Warizaya, T. Tada

Acta Cryst.   F61   808 - 811   2005.08

Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism Reviewed

T. Terasaka, K. Tsuji, T. Kato, I. Nakanishi, T. Kinoshita, Y. Kato, M. Kuno, T. Inoue, K. Tanaka and K. Nakamura

J. Med. Chem.   48   4750 - 4753   2005.08

Structural basis of compound recognition by adenosine deaminase Reviewed

T. Kinoshita, I. Nakanishi, T. Terasaka, M. Kuno, N. Seki, M. Warizaya, H. Matsumura, T. Inoue, K. Takano, H. Adachi, Y. Mori, T. Fujii

Biochemistry   44   10562 - 10569   2005.08

FR177391, a new anti-hyperlipidemic agent from Serratia Reviewed

B. Sato, H. Nakajima, T. Fujita, S. Takase, S. Yoshimura, T. Kinoshita, H. Terano

J. Antibiot.   58   634 - 639   2005.06

Structure of a high-resolution crystal form of human triosephosphate isomerase: improvement of crystals using the gel-tube method Reviewed

T. Kinoshita, R. Maruki, M. Warizaya, H. Nakajima and S. Nishimura

Acta Cryst.   F61   346 - 349   2005.06

Identification of a selective ERK inhibitor and structural determination of the inhibitor-ERK2 complex Reviewed

M. Ohori, T. Kinoshita, M. Okubo, K. Sato, A. Yamazaki, H. Arakawa, S. Nishimura, N. Inamura, H. Nakajima, M. Neya, T. Fujii

Biochem. Biophys. Res. Commun.   336   357 - 363   2005.06

FR207944, an Antifungal Antibiotic from Chaetomium sp. No.217. II. Isolation and Structure Elucidation Reviewed

M. Kobayashi, S. Yoshimura, T. Kinoshita, M. Hashimoto, S. Hashimoto, S. Takase, A. Fujie, M. Hino, Y. Hori

Biosci. Biotechnol. Biochem.   69   1029 - 1032   2005.06

Solution stirring initiates nucleation and improves the quality of adenosine deaminase crystals Reviewed

H. Adachi, K. Takano, A. Niino, H. Matsumura, T. Kinoshita, M. Warizaya, Y. Mori, T. Sasaki

Acta Cryst.   D61   759 - 762   2005.05

The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. No. 00144 II. Structure determination Reviewed

Y. Ohtsu, S. Yoshimura, T. Kinoshita, S. Takase, H. Nakajima

J. Antiniot.   58   479 - 482   2005.04

ヒト由来ADP-リボースポリメラーゼの立体構造解析：阻害剤結合による活性部位の構造変化 Reviewed

木下誉富

日本結晶学会誌 日本結晶学会   46 ( 6 )   421 - 425   2004.12

Control of protein crystal nucleation and growth using stirring solution Reviewed

A. Niino, H. Adachi, K. Takano, H. Matsumura, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori and T. Sasaki

Jpn. J. Appl. Phys.   43   L1442 - L1444   2004.11

Expression, purification, crystallization and preliminary X-ray diffraction studies of human liver regucalcin Reviewed

M. Warizaya, T. Kinoshita, M. Yamaoka, T. Shibata, N. Saito, H. Nakajima and T. Fujii

Acta Cryst.   D60   2019 - 2021   2004.10

SmI2-mediated reduction of ?,?-difluoro-?,?-enoates with application to the synthesis of functionalized (Z)-fluoroalkene-type dipetide isosteres Reviewed

A. Otaka, J. Watanabe, A. Yukimasa, Y. Sasaki, H. Watanabe, T. Kinoshita, S. Oishi, H. Tamamura, N. Fujii

J. Org. Chem.   69   1634 - 1645   2004.08

Rational approaches to discovery of orally active and brain penetrable PARP inhibitors Reviewed

K. Hattori, Y. Kido, H. Yamamoto, J. Ishida, K. Kamijo, K. Murano, M. Ohkubo, T. Kinoshita, A. Iwashita, K. Mihara, S. Yamazaki, N. Matsuoka, Y. Teramura, H. Miyake

J. Med. Chem.   47   4151 - 4154   2004.08

Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors Reviewed

T. Terasaka, T. Kinoshita, M. Kuno, N. Seki, K. Tanaka, I. Nakanishi

J. Med. Chem.   47   3730 - 3743   2004.07

Generation of protein crystals using a solution-stirring technique Reviewed

H. Adachi, H. Matsumura, A. Niino, K. Takano, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori, T. Sasaki

Jpn. J. Appl. Phys.   43   L762 - L764   2004.07

Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors Reviewed

T. Terasaka, H. Okumura, K. Tsuji, T. Kato, I. Nakanishi, T. Kinoshita, Y. Kato, M. Kuno, N. Seki, Y. Naoe, T. Inoue, K. Tanaka, K. Nakamura

J. Med. Chem.   47   2728 - 2731   2004.06

Improving the quality of protein crystals using stirring crystallization Reviewed

H. Adachi, H. Matsumura, A. Niino, K. Takano, T. Kinoshita, M. Warizaya, T. Inoue, Y. Mori, T. Sasaki

Jpn. J. Appl. Phys.   43   L522 - L525   2004.05

Cloning, expression, purification, crystallization and preliminary diffraction analysis of human liver glyceraldehyde-3-phophate dehydrogenase Reviewed

M. Warizaya, T. Kinoshita, A. Kato, H. Nakajima, T. Fujii

Acta Cryst.   D60   567 - 568   2004.05

Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase Reviewed

T. Kinoshita, I. Nakanishi, M. Warizaya, A. Iwashita, Y. Kido, K. Hattori, T. Fujii

FEBS Letters   556   43 - 46   2004.01

Cloning, expression, purification, crystallization and preliminary diffraction analysis of the C-terminal catalytic domain of human poly(ADP-ribose) polymerase Reviewed

T. Kinoshita, T. Tsutsumi, R. Maruki, M. Warizaya, Y. Ishii, T. Fujii

Acta Cryst.   D60   109 - 111   2004.01

A highly potent non-nucleotide adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization Reviewed

T. Terasaka, T. Kinoshita, M. Kuno, I. Nakanishi

J. Am. Chem. Soc.   126   34 - 35   2004.01

Improving quality and harvest period of protein crystals for structure based drug design: effects of a gel and a magnetic field on bovine adenosine deaminase crystals Reviewed

T. Kinoshita, M. Ataka, M. Warizaya, M. Neya, T. Fujii

Acta Cryst.   D59   1333 - 1335   2003.06

Structure-based de novo design of non-nucleoside adenosine deaminase inhibitors Reviewed

T. Terasaka, I. Nakanishi, K. Nakamura, Y. Eikyu, T. Kinoshita, N. Nishio, A. Sato, M. Kuno, N. Seki, K. Sakane

Bioorg. Med. Chem. Lett.   13   1115 - 1118   2003.06

FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase III. Structure determination Reviewed

H. Mori, Y. Urano, T. Kinoshita, S. Yoshimura, S. Takase, M. Hino

J. Antibiot.   56   181 - 185   2003.02

Crystal structure of bovine adenosine deaminase complexed with 6-hydroxyl-1,6-dihydropurine riboside Reviewed

T. Kinoshita, N. Nishio, I. Nakanishi, A. Sato, T. Fujii

Acta Cryst.   D59   299 - 303   2003.02

True interaction mode of porcine pancreatic elastase with FR136706, a potent peptidyl inhibitor Reviewed

T. Kinoshita, I. Nakanishi, A. Sato, T. Tada

Bioorg. Med. Chem. Lett.   13   21 - 24   2003.01

Regio- and stereoselective synthesis of (E)-alkene trans-Xaa-Pro dipeptide mimetics utilizing organocopper-mediated anti-Sn2' reactions Reviewed

A. Otaka, F. Katagiri, T. Kinoshita, Y. Odagaki, O. Shinya, H. Tamamura, N. Hamanaka N. Fuji

J. Org. Chem.   67   6152 - 6161   2002.10

Enantiometric recognition of amino acids using a chiral spiropyran derivative Reviewed

K. Tsubaki, K. Mukoyoshi, H. Morikawa, T. Kinoshita, K. Fuji

Chirality   14   713 - 715   2002.06

Use of meso-ternaphthalene derivatives: linear recognition of the ?,?-diamines by homoditopic receptors. Synthesis of the proton-ionizable lariat crown ether and chiral recognition of primary amines Reviewed

K. Tsubaki, H. Tanaka, T. Furuta, K. Tanaka, T. Kinoshita, K. Fuji

Tetrahedron   58   5611 - 5617   2002.06

The structure of human recombinant aldose reductase complexed with the potent inhibitor zenarestat Reviewed

T. Kinoshita, H. Miyake, T. Fujii, S. Takakura, T. Goto

Acta Cryst.   D58   622 - 626   2002.04

Synthesis of the proton-ionizable lariat crown ether and chiral recognition of primary amines Reviewed

K. Tsubaki, H. Tanaka, T. Kinoshita, K. Fuji

Tetrahedron   58   1679 - 1684   2002.02

Crystallization and preliminary X-ray diffraction studies of catalase-peroxidase from Synechococcus PCC 7942 Reviewed

K. Wada, T. Tada, Y. Nakamura, T. Kinoshita, M. Tamoi, S. Shigeoka, K.Nishimura

Acta Cryst.   D58   157 - 159   2002.01

Synthesis, structure, and ion-binding properties of new tetraoxacalix[3]arenes Reviewed

K. Tsubaki, T. Morimoto, T. Otsubo, T. Kinoshita, K. Fuji

J. Org. Chem.   66   4083 - 4086   2001.11

Crystallization and preliminary X-ray diffraction analysis of NADP-dependent glyceraldehide-3-dehydrogenase of Synechococcus PCC 7942 Reviewed

Y. Nakamura, T. Tada, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka, K. Nishimura

Acta Cryst.   D57   879 - 881   2001.06

The first example for cycloenatiomeric hexahomooxacalix[3]arenes Reviewed

K. Tsubaki, T. Otsubo, T. Kinoshita, M. Kawada, K. Fuji

Chem. Pharm. Bull.   49   507 - 509   2001.04

Purification, crystallization and preliminary X-ray diffraction analysis of the fructose-1,6/sedoheptulose-1,7-bisphosphatase of Synechococcus PCC 7942 Reviewed

Y. Nakamura, T. Tada, K. Wada, T. Kinoshita, M. Tamoi, S. Shigeoka, K. Nishimura

Acta Cryst.   D57   454 - 456   2001.03

Memory of chirality in diastereoselective α-alkylation of isoleucine and allo-isoleucine derivatives Reviewed

T. Kawabata, J. Chen, H. Suzuki, Y. Nagae, T. Kinoshita, S.Chancharunee, K. Fuji

Org. Lett.   2   3883 - 3885   2000.10

Recognition of the chain length of ?,?-diamines by a meso-ternaphthalene derivative with two crown ethers Reviewed

K. Tsubaki, H. Tanaka, T. Furuta, T. Kinoshita, K. Fuji

Tetrahedron Lett.   41   6089 - 6093   2000.08

Stereoselective synthesis of CF2-substituted phosphothreonine mimetics and their incorporation into peptides using newly developed deprotection procedures Reviewed

A. Otaka, E. Mitsuyama, T. Kinoshita, H. Tamamura, N. Fujii

J. Org. Chem.   65   4888 - 4899   2000.06

A new antimitotic substance, FR182877 Reviewed

S. Yoshimura, B. Sato, T. Kinoshita, S. Takase, H. Terano

J. Antibiot.   53   615 - 622   2000.05

Crystallization and preliminary X-ray analysis of cephalosporin C acylase from Pseudomonas sp. strain N176 Reviewed

T. Kinoshita, T. Tada, Y. Saito, Y. Ishii, A. Sato, M. Murata

Acta Cryst.   D56   458 - 459   2000.04

Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 ? resolution Reviewed

I. Nakanishi, T. Kinoshita, A. Sato, T. Tada

Biopolymers   53   434 - 445   2000.03

Dual CCK-A and CCK-B receptor antagonists (II). Preparation and structure activity relationships of 5-alkyl-9-methyl-1,4-benzodiazepines and discovery of FR208419 Reviewed

S. Tabuchi, H. Ito, H. Sogabe, M. Kuno, T. Kinoshita, I. Katumi, N. Yamamoto, H. Mitsui, Y. Satoh

Chem. Pharm. Bull.   48   1 - 15   2000.01

The supramolecular structure of 1,4-bis(9-fluorenyl)-1,4-dihydro[60]fullerene with hexahomotrioxacalix[3]arene in the solid state Reviewed

The supramolecular structure of 1,4-bis(9-fluorenyl)-1,4-dihydro[60]fullerene with hexahomotrioxacalix[3]arene in the solid state

Hetrocycles   51   2553 - 2556   1999.12

Crystallization and preliminary analysis of bovine adenosine deaminase Reviewed

T. Kinoshita, N. Nishio, A. Sato, M. Murata

Acta Cryst.   D55   2031 - 2032   1999.12

Visualization of molecular length of ?,?-diamines and temperature by a receptor based on phenolphthalein and crown ether Reviewed

K. Fuji, K. Tsubaki, K. Tanaka, N. Hayashi, T. Otsubo, T. Kinoshita

J. Am. Chem. Soc.   121   3807 - 3808   1999.10

Synthesis of the water-soluble adenosine A1 receptor antagonist FR166124 through a novel sequential Horner-Emmons/isomerization reaction Reviewed

S. Kuroda, A. Akahane, H. Itani, S. Nishimura, K. Durkin, T. Kinoshita, K. Sakane

Tetrahedron   55   10351 - 10364   1999.08

Molecular structure of FR901277, a novel inhibitor of human leukocyte elastase, and its binding mode simulation Reviewed

I. Nakanishi, T. Kinoshita, T. Tada, T. Fujita, H. Hatanaka, A. Sato

　   9   2397 - 2402   1999.06

Discovery of FR166124, a novel water-soluble pyrazolo-[1,5-a]pyridine adenosine A1 receptor antagonist Reviewed

S. Kuroda, A. Akahane, H. Itani, S. Nishimura, K. Durkin, T. Kinoshita, Y. Tenda, K. Sakane

Bioorg. Med. Chem. Lett.   9   1979 - 1984   1999.04

Discovery of 6-oxo-3-(2-phenylpyrazolo[1,5alfa]pyridin-3-yl)-1(6H)-pyridazine-butanoic acid (FK838) : A novel non-xanthine adenosine A1 receptor antagonist with potent diruretic activity Reviewed

A. Akahane, H. Katayama, T. Mitsunaga, T. Kato, T. Kinoshita, Y. Kita, T. Kusunoki T. Terai, K. Yoshida, Y. Shiokawa

J. Med. Chem.   42   779 - 783   1999.04

Complexation of C60 with hexahomooxacalix[3]arenes and supramolecular structures of complexes in the solid state Reviewed

K. Tsubaki, K. Tanaka, T. Kinoshita, K. Fuji

Chem. Commun.   895 - 896   1998.12

Palladium-catalyzed asymmetric reduction of allylic esters with a new chiral monodentate ligand, 8-diphenylphosphino-8'-mothoxy-1,1'-binaphthyl Reviewed

K. Fuji, M. Sakurai, T. Kinoshita, T. Kawabata

Tetrahedron Lett.   39   6323 - 6326   1998.12

Stepwise construction of some hexahomooxacalix[3]arenes and their comformations in solid state Reviewed

K. Tsubaki, T. Otsubo, K. Tanaka, K. Fuji, T. Kinoshita

J. Org. Chem.   63   3260 - 3265   1998.05

The first synthesis of an optically active molecular bevel gear with only two cogs on each wheel Reviewed

The first synthesis of an optically active molecular bevel gear with only two cogs on each wheel

Tetrahedron Lett.   39   1373 - 1376   1998.03

Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA: cholesterol O-acyltransferase (ACAT) bearing a pyrazol ring Reviewed

A. Tanaka, T. Terasawa, H. Hagihara, T. Kinoshita, Y. Sakuma, N. Ishibe, M. Sawada, H. Takasugi, H. Tanaka

Bioorg. Med. Chem. Lett.   8   81 - 86   1998.01

Assessment of the activity of 8-diphenylphoosphosphino-8'-mothoxy-1,1'-binaphthyl as a ligand for palladium-catalyzed reactions Reviewed

K. Fuji, M. Sakurai, T. Kinoshita, T. Tada, A. Kuroda, T. Kawabata

Chem. Pharm. Bull.   45   1524 - 1526   1997.10

Structure of the zinc endoprotease from Streptomyces caespitosus Reviewed

G. Kurisu, T. Kinoshita, A. Sugimoto, A. Nagara, Y. Kai, N. Kasai, S. Harada

J. Biochem.   121   304 - 308   1997.02

Unexpectically facile racemization of 8-diphenylphosphinoyl-8'-methoxy-1.1'-binaphthyl Reviewed

K. Fuji, M. Sakurai, N. Tohkai, A. Kuroda, T. Kawabata, Y. Fukazawa, T. Kinoshita, T. Tada

Chem. Commun.   1609 - 1610   1996.12

A novel [3+2] annulation: synthesis and X-ray crystallographic structure of a novel tetrahydropyrazolo[1,5-a]quinoline, an intermediate towards new tricyclic quinolone antibacterials Reviewed

D. Barrett, H. Sasaki, T. Kinoshita, K. Sakane

Chem. Commun.   61 - 62   1996.12

A novel synthesis of the pyrazolo[1,5-a]quinoline ring system. New N1-C2 bridged DNA gyrase inhibitors via a novel tandem 1,4-conjugate addition-Michael [3+2] annulation process Reviewed

D. Barrett, H. Sasaki, T. Kinoshita, A. Fujikawa, K. Sakane

Tetrahedron   52   8471 - 8488   1996.10

Alkylation of 1-[N-(hydroxymethyl)-N-methylamino]-4-quinolones. An improved preparation of intermediates for novel potent tricyclic quinolone antibacterial agents Reviewed

D. Barrett, H. Sasaki, H. Tsutsumi, T. Kinoshita, K. Sakane

Bull. Chem. Soc. Jpn   69   1371 - 1376   1996.09

Studies on Cerebral Protective Agents. X. Synthesis and evaluation of anticonvulsant activities for novel 4,5,6,7-tetrahydrothieno[3,3-c]pyridines and related compounds Reviewed

M. Ohkubo, A. Kuno, K. Katsuta, Y. Ueda, K. Shirakawa, H. Nakanishi, T. Kinoshita, H. Takasugi

Chem. Pharm. Bull.   44   778 - 784   1996.06

Studies on cerebral protective agents. IX. Synthesis of novel 1,2,3,4-tetrahydroisoquinolines as N-Methyl-D-aspartate antagonists Reviewed

M. Ohkubo, A. Kuno, K. Kathuta, Y. Ueda, K. Shirakawa, H. Nakanishi, I. Nakanishi, T. Kinoshita, H. Takasugi

Chem. Pharm. Bull.   44   95 - 102   1996.01

Synthesis of new 1,8-bridged tricyclic quinolones by a novel intramolecular arylation of N-1 tethered malonamides Reviewed

D. Barrett, H. Tsutsumi, T. Kinoshita, M. Murata, K. Sakan

Tetrahedron   51   11125 - 11140   1995.10

Asymmetric synthesis of FR165914: a novel ?3-adrenergic agonist with a benzocycloheptane structure Reviewed

K. Hattori, M. Nagano, T. Kato, I. Nakanishi, K. Imai, T. Kinoshita, K. Sakane

Bioorg. Med. Chem. Lett.   5   2821 - 2823   1995.06

Complete amino acid sequence of a zinc matalloendoprotease from Streptomyces caespitosus Reviewed

S. Harada, T. Kinoshita, N. Kasai, S., Tsunasawa, F. Sakiyama

Eur. J. Biochem.   233   683 - 686   1995.04

Studies on a novel, potent and orally effective cheolecytokinin. An antagonist, FK-480. Synthesis and structure-activity relationships of FK-480 and related compounds Reviewed

Y. Sato, T. Matsuo, H. Sogabe, H. Itoh, T. Tada, T. Kinoshita, K. Yoshida, T. Takaya

Chem. Pharm. Bull.   42   2071 - 2083   1994.06

Crystallization and main-chain structure of neutral protease from Streptomyces caespitosus Reviewed

S. Harada, K.Kitadokoro, T. Kinoshita, Y. Kai, N.Kasai

J. Biochem.   110   46 - 49   1991.01

創薬研究のストラテジー

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金芳堂  2011.03 

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タンパク質結晶の新展開－新しい育成技術から構造解析・応用研究へ－

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シーエムシー出版  2008.05 

MAP2K4-共有結合性阻害剤のX線結晶構造解析 Domestic conference

祐村清悟、山下直之、木下誉富

令和4年度日本結晶学会年会  2022.10  日本結晶学会

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FGFR3/G697Cの触媒機構の解明に向けた構造生物学研究 Domestic conference

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令和4年度日本結晶学会年会  2022.10  日本結晶学会

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令和4年度日本結晶学会年会  2022.10  日本結晶学会

高選択性MAPキナーゼ阻害剤創出に向けた構造基盤 Domestic conference

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令和4年度日本結晶学会年会  2022.10  日本結晶学会

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令和4年度日本結晶学会年会  2022.10  日本結晶学会

Insight into Allosteric ERK2 Inhibitors by using Metadynamics Simulations Domestic conference

2022.10 

Protein Kinase CK2阻害活性を有するプリン誘導体の構造活性相関研究―環式飽和炭化水素置換基の導入― Domestic conference

中谷汐里、西脇敬二、中村真也、露口正人、木下誉富、仲西功

第72回日本薬学会関西支部大会  2022.10  日本薬学会関西支部

MAXS reveals the conformational changes of intrinsically disordered region of MAP2K6 International conference

T. Matsumoto, S. Hasegawa, T. Hasegawa, T. Kinoshita

33th European Crystallographic Meeting  2022.08  European Crystallographic Association

MAXSを活用した蛋白質の構造変化と機能の関係に基づく創薬戦略

松本 崇, 山野 昭人, 村川 優花, 深田 はるみ, 澤 匡明, 木下 誉富

日本農薬学会大会講演要旨集  2022.03  日本農薬学会

インシリコスクリーニングから得たアロステリック阻害剤の選択性に関する考察 Domestic conference

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第49回構造活性相関シンポジウム  2021.11  日本薬学会

CK2a1選択性向上に向けたアロステリック部位の構造知見 Domestic conference

池田朝香、露口正人、中村真也、西脇敬二、仲西功、木下誉富

第49回構造活性相関シンポジウム  2021.11  日本薬学会

高選択性MAP2K阻害剤の開発に向けた構造基盤の構築 Domestic conference

祐村清悟、木下誉富

令和3年（2021年）度日本結晶学会年会  2021.11  日本結晶学会

MAP2K3の非twin結晶の取得に向けた結晶化検討 Domestic conference

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令和3年（2021年）度日本結晶学会年会  2021.11  日本結晶学会

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第35回農薬デザイン研究会  2021.11  日本農薬学会

中性子線結晶構造解析とMDシミュレーションを駆使した酵素反応の理解 Invited Domestic conference

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CBI学会2021年大会スポンサーセッション新世代中性子構造生物学研究会  2021.10  CBI学会

Evaluation of the peptide derived from the N- and C-terminal regions of kinase domain for allosteric control of receptor tyrosine kinase cMet Domestic conference

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第58回ペプチド討論会  2021.10  日本ペプチド学会

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CBI学会2021年大会  2021.10  CBI学会

Insight into allosteric ERK2 inhibitors by using fragment molecular orbital method Domestic conference

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CBI学会2021年大会  2021.10  CBI学会

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第21回日本蛋白質科学会年会  2021.06  日本蛋白質科学会

KIMサイト結合型ERK2キナーゼ阻害剤の作用機序の解明 Domestic conference

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第21回日本蛋白質科学会年会  2021.06  日本蛋白質科学会

プリン骨格を有するCK2阻害剤の構造活性相関研究　プリン骨格の互変異性の検討

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Laboratory Training in Drug Discovery Sciences & Technology II

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Experiment in Biological Science II

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