Updated on 2024/10/08

写真a

 
Hatoya Shingo
 
Organization
Graduate School of Veterinary Science Department of Veterinary Science Professor
School of Veterinary Science Department of Veterinary Science
Title
Professor
Affiliation
Institute of Veterinary Science
Contact information
メールアドレス
Affiliation campus
Rinku Campus

Position

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Professor  2023.10 - Now

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - 2023.09

  • School of Veterinary Science Department of Veterinary Science 

    Professor  2023.10 - Now

  • School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - 2023.09

Degree

  • 獣医学博士 ( Others )

Research Areas

  • Life Science / Veterinary medical science  / 臨床獣医学

Research Interests

  • 応用獣医学

  • 臨床獣医学

  • regenerative medicine

  • induced pluripotent stem cell

Research subject summary

  • イヌおよびネコiPS細胞を用いた再生医療研究

  • ネコ体外受精方法の確立およびES細胞株の樹立

  • 間葉系幹細胞を用いた難治性内科疾患の治療

Research Career

  • イヌおよびネコiPS細胞を用いた再生獣医療への応用

    イヌ、ネコ、再生獣医療、iPS細胞  Joint Research in Japan

    2000 - Now 

  • 間葉系幹細胞を用いた難治性内科疾患の治療

    間葉系幹細胞、犬、猫、内科疾患、MSC  Joint Research in Japan

    2000 - Now 

  • 小動物の内科疾患診断・治療に対する臨床研究

    イヌ、ネコ、血液疾患、消化器疾患、内分泌疾患  Individual

    2000 - Now 

  • 小動物の抗菌薬使用に関する臨床研究

    イヌ、ネコ、抗菌薬  Joint Research in Organization

    2000 - Now 

  • ネコ体外受精方法の確立およびES細胞株の樹立

    ネコ、体外受精(IVF)、ES細胞、iPS細胞  Joint Research in Japan

    2000 - Now 

Professional Memberships

  • 獣医再生医療学会

    2019.02 - Now   Domestic

  • 日本免疫学会

    2015.06 - Now   Domestic

  • 動物臨床医学会

    2009.04 - Now

  • 大阪府立大学獣医臨床研友会

    2007.04 - Now

  • 日本獣医師会

    2006.02 - Now

  • 大阪府獣医師会

    2006.02 - Now   Domestic

  • 日本再生医療学会

    2005.03 - Now

  • 日本獣医学会

    2002.02 - Now

▼display all

Committee Memberships (off-campus)

  • 令和5年度日本獣医師会獣医学術学会年次大会 企画実行委員会委員   日本獣医師会  

    2023.04 - 2024.03 

  • 令和3年度日本獣医師会獣医学術学会年次大会 企画実行委員会委員   日本獣医師会  

    2021.04 - 2022.03 

  • 理事   一般社団法人 日本獣医再生医療学会  

    2021.02 - Now 

Awards

  • 中村賞

    2023.06   大阪府獣医師会  

  • 第141回日本獣医学会 獣医学奨励賞

    2006.03   社団法人 日本獣医学会  

  • 学長顕彰

    2006.03   大阪府立大学  

  • 第141回 日本獣医学会 大会長賞

    2006.03   社団法人 日本獣医学会  

  • 日本獣医師会長賞(成績優秀者)

    2002.03   日本獣医師会  

Job Career (off-campus)

  • Osaka Metropolitan University

    2023.10 - Now

Papers

  • Generation of canine induced pluripotent stem cells under feeder-free conditions using Sendai virus vector encoding six canine reprogramming factors Reviewed

    Masaya Tsukamoto, Kazuto Kimura, Takumi Yoshida, Miyuu Tanaka, Mitsuru Kuwamura, Taro Ayabe, Genki Ishihara, Kei Watanabe, Mika Okada, Minoru Iijima, Mahito Nakanishi, Hidenori Akutsu, Kikuya Sugiura, Shingo Hatoya

    Stem Cell Reports   19 ( 1 )   141 - 157   2024.01( ISSN:2213-6711

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1016/j.stemcr.2023.11.010

    PubMed

  • Canine induced pluripotent stem cells can be successfully maintained in weekend-free culture systems

    KIMURA Kazuto, NAGAKURA Hiroya, TSUKAMOTO Masaya, YOSHIDA Takumi, SUGISAKI Hiroko, SHISHIDA Kohei, TACHI Yuta, SHIMASAKI Shoko, SUGIURA Kikuya, HATOYA Shingo

    Journal of Veterinary Medical Science   advpub ( 0 )   2024( ISSN:09167250 ( eISSN:13477439

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    International / domestic magazine:International journal  

    <p>Canine induced pluripotent stem cells (ciPSCs) can provide useful insights into novel therapies in both veterinary and medical fields. However, limited accessibility to the present culture medium and requirement of considerable time, effort, and cost for routine ciPSC maintenance restrict advancement in ciPSC research. In addition, it is unknown whether ciPSC culture conditions influence differentiation propensity. We investigated the availability of the common human pluripotent stem cells (hPSCs) culture systems for ciPSC maintenance and the differentiation propensities of the ciPSCs maintained in these culture systems. StemFlex and mTeSR Plus supported PSC-like colony formation and pluripotency markers expression in ciPSCs even after five passages. Additionally, ciPSCs were maintained under weekend-free culture conditions with a stable growth rate, pluripotency marker expression, and differentiation abilities using vitronectin (VTN-N) and Geltrex. Following maintenance of spontaneously differentiated ciPSCs under various conditions by embryoid body formation, there were few differences in the differentiation propensities of ciPSCs among the tested culture conditions. Thus, ciPSCs were successfully cultured under weekend-free conditions for ciPSC maintenance using StemFlex or mTeSR Plus with VTN-N or Geltrex. The present study offers simpler and more effort-, time-, and cost-saving options for ciPSC culture systems, which may lead to further development in research using ciPSCs.</p>

    DOI: 10.1292/jvms.23-0422

    PubMed

  • Generation, characterization, and differentiation of induced pluripotent stem-like cells in the domestic cat Reviewed

    KANEGI Ryoji, HATOYA Shingo, KIMURA Kazuto, YODOE Kyohei, NISHIMURA Toshiya, SUGIURA Kikuya, KAWATE Noritoshi, INABA Toshio

    Journal of Reproduction and Development   69 ( 6 )   317 - 327   2023.12( ISSN:09168818 ( eISSN:13484400

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    <p> Induced pluripotent stem (iPS) cells are generated from somatic cells and can differentiate into various cell types. Therefore, these cells are expected to be a powerful tool for modeling diseases and transplantation therapy. Generation of domestic cat iPS cells depending on leukemia inhibitory factor has been reported; however, this strategy may not be optimized. Considering that domestic cats are excellent models for studying spontaneous diseases, iPS cell generation is crucial. In this study, we aimed to derive iPS cells from cat embryonic fibroblasts retrovirally transfected with mouse <i>Oct3/4, Klf4, Sox2,</i> and <i>c-Myc</i>. After transfection, embryonic fibroblasts were reseeded onto inactivated SNL 76/7 and cultured in a medium supplemented with basic fibroblast growth factor. Flat, compact, primary colonies resembling human iPS colonies were observed. Additionally, primary colonies were more frequently observed in the KnockOut Serum Replacement medium than in the fetal bovine serum (FBS) medium. However, enhanced maintenance and proliferation of iPS-like cells occurred in the FBS medium. These iPS-like cells expressed embryonic stem cell markers, had normal karyotypes, proliferated beyond 45 passages, and differentiated into all three germ layers <i>in vitro</i>. Notably, expression of exogenous Oct3/4, Klf4, and Sox2 was silenced in these cells. However, the iPS-like cells failed to form teratomas. In conclusion, this is the first study to establish and characterize cat iPS-like cells, which can differentiate into different cell types depending on the basic fibroblast growth factor.</p>

    DOI: 10.1262/jrd.2022-038

    PubMed

  • In vivo transfection of cytokine genes into tumor cells using a synthetic vehicle promotes antitumor immune responses in a visceral tumor model Reviewed International coauthorship

    Shunichi Watanabe, Ayaka Takagi, Eiji Yuba, Chie Kojima, Nanako Dei, Akikazu Matsumoto, Jun Tanikawa, Tetsuya Kawamura, Nadeeka H. De Silva, Takeshi Izawa, Takashi Akazawa, Ryoji Kanegi, Shingo Hatoya, Toshio Inaba, Kikuya Sugiura

    The FASEB Journal   37 ( 11 )   e23228   2023.10( ISSN:0892-6638 ( eISSN:1530-6860

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Abstract

    The tumor microenvironment (TME) strongly affects the clinical outcomes of immunotherapy. This study aimed to activate the antitumor immune response by manipulating the TME by transfecting genes encoding relevant cytokines into tumor cells using a synthetic vehicle, which is designed to target tumor cells and promote the expression of transfected genes. Lung tumors were formed by injecting CT26.WT intravenously into BALB/c mice. Upon intravenous injection of the green fluorescent protein‐coding plasmid encapsulated in the vehicle, 14.2% tumor‐specific expression was observed. Transfection of the granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) and CD40 ligand (L)‐plasmid combination and interferon gamma (IFNγ) and CD40L‐plasmid combination showed 45.5% and 54.5% complete remission (CR), respectively, on day 60; alternate treatments with both the plasmid combinations elicited 66.7% CR, while the control animals died within 48 days. Immune status analysis revealed that the density of dendritic cells significantly increased in tumors, particularly after GM‐CSF‐ and CD40L‐gene transfection, while that of regulatory T cells significantly decreased. The proportion of activated killer cells and antitumoral macrophages significantly increased, specifically after IFNγ and CD40L transfection. Furthermore, the level of the immune escape molecule programmed death ligand‐1 decreased in tumors after transfecting these cytokine genes. As a result, tumor cell‐specific transfection of these cytokine genes by the synthetic vehicle significantly promotes antitumor immune responses in the TME, a key aim for visceral tumor therapy.

    DOI: 10.1096/fj.202202036r

    PubMed

  • Genetic and phenotypic analyses of mcr-harboring extended-spectrum β-lactamase-producing Escherichia coli isolates from companion dogs and cats in Japan Reviewed

    Mayo Yasugi, Shingo Hatoya, Daisuke Motooka, Daisuke Kondo, Hideo Akiyoshi, Masayuki Horie, Shota Nakamura, Terumasa Shimada

    Veterinary Microbiology   280   2023.05( ISSN:0378-1135 ( eISSN:1873-2542

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    The emergence of mcr plasmid-mediated colistin-resistant extended-spectrum β-lactamase (ESBL)-producing Enterobacterales among companion dogs and cats poses a risk of the animals acting as reservoirs for cross-species transmission. However, current knowledge of mcr-harboring ESBL-producing Enterobacterales in companion dogs and cats is still limited; thus, the genetic and phenotypic characteristics of the bacterial isolates and plasmids, in companion dogs and cats, remain to be elucidated. Here, we identified mcr gene-harboring ESBL-producing Escherichia coli isolates during whole-genome sequencing of ESBL-producing E. coli isolates from a dog and a cat in Osaka, Japan. Colistin-resistant MY732 isolate from a dog carried two plasmids: mcr-1.1-harboring IncI2 plasmid and blaCTX-M-14-harboring IncFIB plasmid. Conjugation assays revealed that both plasmids can be co-transferred even though the IncFIB plasmid lacked a conjugal transfer gene cassette. The other isolate MY504 from a cat harbored two bla genes and mcr-9 on the identical IncHI2 plasmid. This isolate was not resistant to colistin, which is likely to be due to deletion of the regulatory two-component QseBC system associated with the mcr-9 expression. To the best of our knowledge, this is the first report of a colistin-resistant ESBL-producing E. coli isolate harboring mcr-1 from a companion dog in Japan. Given that the mcr gene-harboring IncI2 and IncHI2 plasmids in this study shared high homology with plasmids from human or animal-derived Enterobacterales, companion dogs and cats may act as important reservoirs for cross-species transmission of the mcr gene in the community, in Japan.

    DOI: 10.1016/j.vetmic.2023.109695

    PubMed

  • Hypoxia-targeting therapy for intestinal T-cell lymphoma in dogs: Preclinical study using 3D in vitro models Reviewed

    Hiroki Yamazaki, Toshiyuki Tanaka, Hidetaka Nishida, Shingo Hatoya, Hideo Akiyoshi

    VETERINARY AND COMPARATIVE ONCOLOGY   21 ( 1 )   12 - 19   2023.03( ISSN:1476-5810 ( eISSN:1476-5829

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    The transcription factor hypoxia-inducible factor 1 alpha (HIF-1 alpha) is activated in response to oxygen deficiency, and is expressed in several cancers under intratumoral hypoxic stress that arises during pathogenic processes. Hypoxic stimulation enhanced the growth potential of canine lymphoma cells by activating the HIF-1 alpha signalling pathway in a previously reported study. The aim of this study was to establish a molecular design strategy for a novel hypoxia-targeting therapy for intestinal T-cell lymphoma (ITL) in dogs. We assessed the relationship between immunohistochemistry-based HIF-1 alpha expression and clinical information, including signalment, tumour area, clinical signs, systemic diseases, treatment protocol, follow-up information, chemotherapy response and overall survivals (OS), using 48 tissue samples from dogs with ITL. We investigated the effects of hypoxic stimulation on the biological behaviour of cell lines from three different types of canine ITL. We assessed the effects of evofosfamide (Evo; hypoxia-activated prodrug) on cell lines cultured under hypoxic conditions. Our data showed that treatment response and overall survival might be significantly decreased in dogs with higher HIF-1 alpha expression than in those with lower HIF-1 alpha expression. Hypoxic culture (1% O-2, 72 h) enhanced the invasiveness of cell lines and decreased their sensitivity to CCNU, resulting in hypoxia-dependent aggressive behaviour. Sensitivity to Evo significantly increased in cell lines cultured under hypoxia compared with those cultured under normoxia, which exhibited hypoxia-dependent apoptosis. Additionally, Evo downregulated HIF-1 alpha expression in cell lines cultured under hypoxia, suggesting that Evo might inhibit cell growth by inactivating HIF-1 alpha-dependent cell signalling. Our results revealed the preclinical antitumor activity of Evo and provide a rationale for treatment strategies for dogs with ITL.

    DOI: 10.1111/vco.12855

    PubMed

  • Assessment of hypoxia-targeting therapy for gastrointestinal lymphoma in dogs: Preclinical test using murine models. Reviewed

    Hiroki Yamazaki, Toshiyuki Tanaka, Hidetaka Nishida, Shingo Hatoya, Hideo Akiyoshi

    Research in veterinary science   154   22 - 28   2023.01( ISSN:00345288

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    The transcription factor hypoxia-inducible factor 1α (HIF-1α) is expressed in several cancers under intratumoral hypoxic stress that arises during pathogenic processes, resulting in malignant progression. We previously reported that hypoxic stimulation enhances the growth potential of canine lymphoma cells by activating the HIF-1α signaling pathway. In contrast, evofosfamide (Evo) releases a DNA-alkylating moiety within hypoxic tumor regions, suggesting that Evo could serve as a hypoxia-targeting drug in canine lymphoma. This study aimed to use Evo to evaluate hypoxia-targeted therapy in dogs with gastrointestinal lymphoma (GIL) and investigate how Evo affects antitumor efficacy and adverse events in three type of murine xenograft models using T-cell GIL cells. In vitro tests, the sensitivity to Evo of three T-cell GIL cell lines under hypoxic culture was significantly higher than that under normoxic culture. Our metabolic analysis suggested that the three murine models might have high reproducibility as clinical cases in canine GIL. Our data showed that Evo showed significantly higher tumor growth potential and fewer adverse events in three type of murine models compared to lomustine; CeeNu (CCNU). Additionally, Evo suppressed the expression of HIF-1α protein in tumor tissues, suggesting that it may preferentially target and inhibit tumor cells in a hypoxic region. The evidence presented here supports the favorable preclinical evaluation that Evo may be effective for GIL in dogs.

    DOI: 10.1016/j.rvsc.2022.11.003

    PubMed

  • Atypical hypoadrenocorticism with intact zona glomerulosa of the adrenal cortex after long-term observation: a case report of a dog Reviewed

    HATOYA Shingo, KANEGI Ryoji, NABETANI Tomoyo, OJI Shoko, IZAWA Takeshi, HIRAI Satoshi, SUGIURA Kikuya

    Journal of Veterinary Medical Science   85 ( 1 )   9 - 13   2023.01( ISSN:09167250 ( eISSN:13477439

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    <p>An 8-year-old intact male pointer presented with lethargy and hypoalbuminemia. On abdominal ultrasonography, both adrenal glands were reduced in thickness. Based on the ACTH stimulation test results and the absence of electrolyte abnormalities, the dog was diagnosed with atypical hypoadrenocorticism. After treatment with low-dose prednisolone, his general condition improved, and blood tests normalized. The dog died 818 days later, and a complete autopsy was performed. Histologically, the architecture of the zonae fasciculata and reticularis was disrupted in both adrenal glands; however, the zona glomerulosa remained relatively normal. In summary, in this study, we detailed the pathological presentation of atypical hypoadrenocorticism without electrolyte abnormalities.</p>

    DOI: 10.1292/jvms.22-0322

    PubMed

  • Canine induced pluripotent stem cells efficiently differentiate into definitive endoderm in 3D cell culture conditions using high-dose activin A Reviewed

    Masaya Tsukamoto, Kazuto Kimura, Takumi Yoshida, Kikuya Sugiura, Shingo Hatoya

    Regenerative Therapy   21   502 - 510   2022.12( ISSN:2352-3204

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1016/j.reth.2022.10.002

    PubMed

    Other URL: https://linkinghub.elsevier.com/retrieve/pii/S2352-3204(22)00099-2

  • Generation of molecular-targeting helix-loop-helix peptides for inhibition of the interaction between cytotoxic T-lymphocyte-associated protein 4 and B7 in the dog Reviewed International coauthorship

    Tharanga MR RAMANAYAKE MUDIYANSELAGE, Daisuke FUJIWARA, Masataka MICHIGAMI, Shunichi WATANABE, Zhengmao YE, Atsuko UYEDA, Ryoji KANEGI, Shingo HATOYA, Ikuo FUJII, Kikuya SUGIURA

    Journal of Veterinary Medical Science   84 ( 8 )   1101 - 1107   2022.08( ISSN:0916-7250 ( eISSN:1347-7439

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1292/jvms.21-0318

  • Mesenteric lymph node abscesses due to Escherichia coli in a cat Reviewed

    Kosei Sakai, Ryoji Kanegi, Tomoyo Nabetani, Toshiyuki Tanaka, Shunsuke Shimamura, Terumasa Shimada, Kikuya Sugiura, Shingo Hatoya

    Veterinary Medicine and Science   8 ( 4 )   1611 - 1616   2022.07( ISSN:2053-1095 ( eISSN:2053-1095

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    Authorship:Last author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1002/vms3.840

    Other URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/vms3.840

  • Potent adjuvant effect elicited for tumor immunotherapy by a liposome conjugated pH-sensitive polymer and dendritic cell-targeting Toll-like-receptor ligand Reviewed International coauthorship

    Shunichi Watanabe, Eiji Yuba, Takashi Akazawa, Viskam Wijewardana, Yuka Kakihara, Ayaka Azuma, Kenji Hagimori, Ryoji Kanegi, Shingo Hatoya, Norimitsu Inoue, Toshio Inaba, Kikuya Sugiura

    Vaccine   40 ( 10 )   1448 - 1457   2022.03( ISSN:0264-410X

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1016/j.vaccine.2022.01.048

  • Effects of the preservation medium and storage duration of domestic cat ovaries on the maturational and developmental competence of oocytes in vitro Reviewed International coauthorship

    Takumi YOSHIDA, Md Emtiaj ALAM, Keisuke HANAFUSA, Yasunori TSUJIMOTO, Masaya TSUKAMOTO, Ryoji KANEGI, Toshio INABA, Kikuya SUGIURA, Shingo HATOYA

    68 ( 2 )   160 - 164   2022.01

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    Authorship:Last author, Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • Retrospective evaluation of nimustine use in the treatment of feline lymphoma. Reviewed

    Sakai K, Hatoya S, Furuya M, Nabetani T, Kanegi R, Shimamura S, Tani H, Shimada T.

    2021.10

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • Quality of life-improving effect of autologous ex vivo expanded cytotoxic and opioid-producing lymphocyte for dogs with cancers. Reviewed

    Mitani K, Ito Y, Takene Y, Hatoya S, Sugiura K, Inaba T.

    Vet Immunol Immunopathol. 雑誌   2021.08

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    Kind of work:Joint Work  

  • Quality of life-improving effect of autologous ex vivo expanded cytotoxic and opioid-producing lymphocytes for dogs with cancers. Reviewed

    Kosuke Mitani, Yuki Ito, Yukio Takene, Shingo Hatoya, Kikuya Sugiura, Toshio Inaba

    Veterinary immunology and immunopathology   238   110292 - 110292   2021.08

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    Activated lymphocyte therapy is one of the immunotherapies for cancer patients that is expected to prolong life without any adverse effects and maintain satisfactory quality of life (QOL). However, the objective assessment and maintenance of a standardized evaluation of QOL are not easy. We aimed to evaluate activated autologous lymphocyte therapy for cancer dogs using the characteristics of the cultured cells and QOL as perceived by owners. In in vitro experiments, peripheral blood mononuclear cells (PBMCs) collected from healthy dogs were stimulated using anti-CD3 antibody and recombinant interleukin-2 under a closed system. The number of CD4+ and CD8+ T lymphocytes in the cultured cells was higher than that of PBMCs (P < 0.05). Natural killer activity, proenkephalin (known as the precursor of endogenous opioids) and interferon-γ mRNA in activated lymphocytes were significantly higher than in PBMCs (P < 0.05). Met-enkephalin was detected in activated lymphocytes. QOL of 58 dogs afflicted with common types of cancers in humans increased after every administration of activated lymphocyte therapy (P < 0.05). Overall, these results indicated that activated lymphocyte therapy could have beneficial effects on QOL in dogs with cancers. This was objectively evaluated and this improvement was related to presence of opioid-producing lymphocytes.

    DOI: 10.1016/j.vetimm.2021.110292

    PubMed

  • Canine induced pluripotent stem cell maintenance under feeder-free and chemically-defined conditions Reviewed

    Kimura K, Tsukamoto M, Yoshida T, Tanaka M, Kuwamura M, Ohtaka M, Nishimura K, Nakanishi M, Sugiura K, Hatoya S.

    Mol Reprod Dev. 雑誌   88 ( 6 )   395 - 404   2021.06

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    Kind of work:Joint Work  

  • Influence of hypomagnesemia on disease severity and prognosis in dogs with lymphocytic-plasmacytic enteritis Reviewed

    Kosei SAKAI, Shingo HATOYA, Masaru FURUYA, Shunsuke SHIMAMURA, Tomoyo NABETANI, Hiroyuki TANI, Terumasa SHIMADA

    Journal of Pet Animal Nutrition 雑誌   24 ( 1 )   1 - 13   2021.04

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    Kind of work:Joint Work  

  • イヌのリンパ球形質細胞性腸炎における低マグネシウム血症が重症度や予後に及ぼす影響(Influence of hypomagnesemia on disease severity and prognosis in dogs with lymphocytic-plasmacytic enteritis) Reviewed

    酒居 幸生, 鳩谷 晋吾, 古家 優, 島村 俊介, 鍋谷 知代, 谷 浩行, 嶋田 照雅

    ペット栄養学会誌   24 ( 1 )   1 - 13   2021.04( ISSN:1344-3763

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    ヒトの炎症性腸疾患において、血中マグネシウム濃度は一部の患者で低下し、腸炎の重症度と負の相関を示す。ヒトと同様に、イヌのリンパ球形質細胞性腸炎(LPE)においても低マグネシウム血症が認められるが、病態との関連は不明である。そこで本研究では、イヌLPE症例における血中マグネシウム濃度を測定し、腸炎の重症度や予後との関連を検討することを目的とした。病理組織学的にLPEと診断されたイヌ35頭を組み入れた。診断時における腸炎の組織学的重症度(軽度、中等度または重度)、イヌ炎症性腸疾患活動性指標(CIBDAI)、イヌ慢性腸症活動性指標(CCECAI)を評価し、血清中マグネシウム濃度との関連を検討した。また、低マグネシウム血症の有無で症例を2群に分け、診断後の生存期間を比較した。低マグネシウム血症は22頭(63%)で検出された。血中マグネシウム濃度は腸炎の組織学的重症度、CIBDAIおよびCCECAIと負の相関を示した。低マグネシウム血症の有無で症例の生存期間に有意差は認められなかった。以上のことから、イヌLPE症例における血中マグネシウム濃度は腸炎の重症度を反映しており、バイオマーカーとして有用であると考えられた。(著者抄録)

  • Long-Term Trypsin Treatment Promotes Stem Cell Potency of Canine Adipose-Derived Mesenchymal Stem Cells Reviewed

    Kosuke Mitani, Yuki Ito, Yukio Takene, Shingo Hatoya, Kikuya Sugiura, Toshio Inaba

    Stem Cells Dev. 雑誌   30 ( 6 )   337 - 349   2021.03

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    Kind of work:Joint Work  

  • Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan Reviewed

    Mayo Yasugi, Shingo Hatoya, Daisuke Motooka, Yuki Matsumoto, Shunsuke Shimamura, Hiroyuki Tani, Masaru Furuya, Keiichiro Mie, Masami Miyake, Shota Nakamura, Terumasa Shimada

    PLoS One. 雑誌   16 ( 2 )   2021.02

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    Kind of work:Joint Work  

  • Efficient Reprogramming of Canine Peripheral Blood Mononuclear Cells into Induced Pluripotent Stem Cells Reviewed

    Kazuto Kimura, Masaya Tsukamoto, Miyuu Tanaka, Mitsuru Kuwamura, Manami Ohtaka, Ken Nishimura, Mahito Nakanishi, Kikuya Sugiura, Shingo Hatoya

    Stem Cells Dev. 雑誌   30 ( 2 )   79 - 90   2021.01

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  • Generation of Footprint-Free Canine Induced Pluripotent Stem Cells from Peripheral Blood Mononuclear Cells Using Sendai Virus Vector Reviewed

    Tsukamoto M, Kimura K, Tanaka M, Kuwamura M, Ohtaka M, Nakanishi M, Sugiura K, Hatoya S.

    Mol Reprod Dev. 雑誌   87 ( 6 )   663 - 665   2020.06

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    Repository URL: http://hdl.handle.net/10466/00017661

  • Hepatocellular necrosis with prominent regenerative reactions in a zonisamide administrated dog Reviewed

    Takami Y, Izawa T, Tanaka M, Hatoya S, Nabetani T, Yamate J, Kuwamura M.

    J Vet Med Sci 雑誌   82 ( 6 )   704 - 706   2020.06

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  • Decreased serum zinc concentration in dogs with lymphocytic-plasmacytic enteritis, and its associations with disease severity and prognosis

    Sakai K, Hatoya S, Furuya M, Shimamura S, Nabetani T, Tani H, Shimada T.

    J Vet Med Sci . 雑誌   82 ( 6 )   759 - 763   2020.06

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  • Canine mesenchymal stromal cell-conditioned medium promotes survival and neurite outgrowth of neural stem cells Reviewed

    Nakamura M, Nishida H, Yoshizaki K, Akiyoshi H, Hatoya S, Sugiura K, Inaba T.

    J Vet Med Sci 雑誌   85 ( 2 )   668 - 672   2020.05

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  • Development of feline embryos produced using freeze-dried sperm Reviewed

    Tsujimoto Y, Kaneko T, Yoshida T, Kimura K, Inaba T, Sugiura K, Hatoya S.

    Theriogenology 雑誌   147   71 - 76   2020.04

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    Repository URL: http://hdl.handle.net/10466/00017663

  • Distribution of infectious endogenous retroviruses in mixed-breed and purebred cats Reviewed

    Ngo MH, Soma T, Youn HY, Endo T, Makundi I, Kawasaki J, Miyake A, Nga BTT, Nguyen H, Arnal M, Fernández de Luco D, Deshapriya RMC, Hatoya S, Nishigaki K.

    Arch Virol 雑誌   165 ( 1 )   157 - 167   2020.01

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  • Manipulation of the tumor microenvironment by cytokine gene transfection enhances dendritic cell-based immunotherapy Reviewed

    Wijesekera DPH, Yuba E, De Silva NH, Watanabe SI, Tsukamoto M, Ichida C, Izawa T, Itoh K, Kanegi R, Hatoya S, Yamate J, Inaba T, Sugiura K.

    FASEB Bioadv 雑誌   2 ( 1 )   5 - 17   2019.11

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  • Clinical findings and treatment of disseminated 'Mycobacterium avium subspecies hominissuis' infection in a domestic cat. Reviewed

    Kanegi R, Yasugi M, Nabetani T, Tanaka T, Wada Y, Hirai K, Sugiura K, Hatoya S.

    Journal of Veterinary Medical Science. 雑誌   81 ( 12 )   1842 - 1849   2019.10

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  • Development of feline embryos produced by Piezo-actuated intracytoplasmic sperm injection of elongated spermatids. Reviewed

    Tsujimoto Y, Fujiki K, Alam ME, Tsukamoto M, Azuma R, Kanegi R, Anzai M, Inaba T, Sugiura K, Hatoya S*.

    Journal of Reproduction and Development 雑誌   65   1577 - 1586   2019.06

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  • Feline embryo development in commercially available human media supplemented with fetal bovine serum. Reviewed

    Alam ME, Iwata J, Fujiki K, Tsujimoto Y, Kanegi R, Kawate N, Tamada H, Inaba T, Sugiura K, Hatoya S*.

    Journal of Veterinary Medical Science 雑誌   81   629 - 635   2019.04

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  • Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases. Reviewed

    Aono K, Azuma YT*, Nabetani T, Hatoya S, Furuya M, Miki M, Hirota K, Fujimoto Y, Nishiyama K, Ogata Y, Mochizuki T, Tani H.

    Veterinary Immunology and Immunopathology 雑誌   210   15 - 22   2019.04

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  • Generation of Footprint-Free Canine Induced Pluripotent Stem Cells Using Auto-Erasable Sendai Virus Vector. Reviewed

    Tsukamoto M, Nishimura T, Yodoe K, Kanegi R, Tsujimoto Y, Alam ME, Kuramochi M, Kuwamura M, Ohtaka M, Nishimura K, Nakanishi M, Inaba T, Sugiura K, Hatoya S※.

    Stem Cells and Development 雑誌   27   1577 - 1586   2018.11

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    Repository URL: http://hdl.handle.net/10466/00017662

  • Efficacy of mechanical micro-vibration in the development of bovine embryos during in vitro maturation and culture.

    Takahashi M, Honda T, Hatoya S, Inaba T, Kawate N, Tamada H.

    J Vet Med Sci. 雑誌   80 ( 3 )   532 - 535   2018.03

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  • Innate immunity mediated by dendritic cells/macrophages plays a central role in the early period in tumor treatment using gene of Mycobacterium tuberculosis antigen.

    Ushigusa T, Koyama Y, Ito T, Watanabe K, Chambers JK, Hasegawa A, Uchida K, Kanegi R, Hatoya S, Inaba T, Sugiura K.

    J Vet Med Sci. 雑誌   80 ( 2 )   190 - 196   2018.02

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  • Development of effective tumor immunotherapy using a novel dendritic cell-targeting Toll-like receptor ligand. Reviewed

    De Silva NH, Akazawa T, Wijewardana V, Inoue N, Oyamada M, Ohta A, Tachibana Y, Wijesekera DPH, Kuwamura M, Nishizawa Y, Itoh K, Izawa T, Hatoya S, Hasegawa T, Yamate J, Inaba T, Sugiura K.

    PLoS One 雑誌   12 ( 11 )   2017.11

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  • Analysis of IMP-1 type metallo-β-lactamase-producing Acinetobacter radioresistens isolated from companion animals. Reviewed

    Kimura Y, Miyamoto T, Aoki K, Ishii Y, Harada K, Watarai M, Hatoya S.

    J Infect Chemother. 雑誌   23 ( 9 )   655 - 657   2017.09

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  • In vitro efficacy of 16 antimicrobial drugs against a large collection of β-lactamase-producing isolates of extraintestinal pathogenic Escherichia coli from dogs and cats.

    Shimizu T, Harada K, Tsuyuki Y, Kimura Y, Miyamoto T, Hatoya S, Hikasa Y.

    J Med Microbiol. 雑誌   66 ( 8 )   1085 - 1091   2017.08

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  • Generation of Canine-Induced Extraembryonic Endoderm-Like Cell Line That Forms Both Extraembryonic and Embryonic Endoderm Derivatives. Reviewed

    Nishimura T1 Unezaki N, Kanegi R, Wijesekera DPH, Hatoya S, Sugiura K, Kawate N, Tamada H, Imai H, Inaba T.

    Stem Cells Dev. 雑誌   26 ( 15 )   1111 - 1120   2017.08

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  • Feeder-independent canine induced pluripotent stem cells maintained under serum-free conditions. Reviewed

    Nishimura T, Hatoya S, Kanegi R, Wijesekera DPH, Sanno K, Tanaka E, Sugiura K, Hiromitsu Tamada NK, Imai H, Inaba T.

    Mol Reprod Dev 雑誌   84 ( 4 )   329 - 339   2017.04

  • Long-term feeding of hydroalcoholic extract powder of Lepidium meyenii (maca) enhances the steroidogenic ability of Leydig cells to alleviate its decline with ageing in male rats. Reviewed

    Yoshida K, Ohta Y, Kawate N, Takahashi M, Inaba T, Hatoya S, Morii H, Takahashi K, Ito M, Tamada H.

    Andrologia 雑誌   2017.03

  • 愛玩用モルモットからのメチシリン耐性Staphylococcus haemolyticusの分離 Reviewed

    宮本 忠, 木村 唯, 鳩谷 晋吾, 青木 弘太郎, 石井 良和

    日本獣医師会雑誌 雑誌   69 ( 10 )   612 - 615   2016.10

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  • Production of feline leukemia inhibitory factor (LIF) with biological activity in Escherichia coli Reviewed

    Kanegi R(学生), Hatoya S, Tsujimoto Y(学生), Takenaka S, T. Nishimura T(学生), Wijewardana V(学生), Sugiura K, Takahashi M, Kawate N, Tamada H, Inaba T.

    Theriogenology 雑誌   2016.07

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  • Feeding hydroalchoholic extract powder of Lepidium meyenii (maca) increases serum testosterone concentration and enhances steroidogenic ability of Leydig cells in adult male rats Reviewed

    Ohta Y(学生), Yoshida K(学生), Kamiya S(学生), Kawate N, Takahashi M, Inaba T, Hatoya S, Morii H, Takahashi K, Ito M, Ogawa H, Tamada H

    Andrologia 雑誌   48 ( 3 )   2016.04

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  • Positive correlation between patency and mRNA levels for cyclooxygenase-2 and prostaglandin E synthase in the uterine cervix of bitches with pyometra

    Tamada , Adachi N, Kawate N, Inaba T, Hatoya S, Sawada T.

    J Vet Med Sci 雑誌   78 ( 3 )   2016.04

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  • Expression and localization of epidermal growth factor, transforming growth factor- α and epidermal growth factor receptor in the canine testis Reviewed

    Tamada H, Takemoto K, Tominaga M, Kawate N, Takahashi M, Hatoya S, Matsuyama S, Inaba T, Sawada T.

    J Reprod Dev   62 ( 1 )   2016.02

  • Expression analyses of insulin-like peptide 3 and its receptor, RXFP2, and LH receptor and 3β-HSD in testes of normal and cryptorchid dogs. Reviewed

    Hannan MA(学生), Kawate N, kubo Y(学生), Pathirana IN(学生), Büllesbach EE, Hatoya S, Inaba T, Takahashi M, Tamada H.

    Theriogenology 雑誌   84 ( 7 )   2015.12

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  • Effect of ovarian hormones on maturation of dendritic cells from peripheral blood monocytes in dogs Reviewed

    Wijewardana V(学生), Sugiura K, Wijesekera DPH(学生), Hatoya S, Nishimura T(学生), Kanegi R(学生), Ushigusa T(学生), Fujii A(学生), Inaba T.

    J Vet Med Sci 雑誌   77 ( 7 )   2015.07

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  • 犬と猫からの臨床分離菌におけるファロペネム耐性株

    宮本 忠、嶋田恵理子、木村 唯、鈴木 尋、村瀬ひろみ、鳩谷晋吾

    動物臨床医学 雑誌   24 ( 1 )   27 - 31   2015.01

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  • 犬猫におけるアシネトバクター属菌の分離状況と薬剤感受性 Reviewed

    木村 唯、嶋田恵理子、宮本 忠、鳩谷晋吾

    日本獣医師会雑誌 雑誌   68 ( 1 )   59 - 63   2015.01

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  • Profiling of serum metabolites in canine lymphoma using gas chromatography mass spectrometry. Reviewed

    Tamai R, Furuya M, Hatoya S, Akiyoshi H, Yamamoto R, Komori Y, Yokoi S, Tani K, Hirano Y, Komori M, Takenaka S.

    J Vet Med Sci 雑誌   76 ( 11 )   1513 - 8   2014.11

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  • Enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a novel type synthetic vector. Reviewed

    Wijesekera DP, Sugiura K, Yuba E, Ueda K, Wijewardana V, Kanegi R, Nishimura T, Ushigusa T, Hatoya S, Kono K, Inaba T.

    Vet Immunol Immunopathol 雑誌   162 ( 1-2 )   59 - 64   2014.11

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  • 1 動物病院における伴侶動物のパスツレラ感染症発生状況と治療成績 Reviewed

    木村 唯、嶋田恵理子、宮本 忠、鳩谷晋吾

    日本獣医師会雑誌 雑誌   67 ( 10 )   761 - 766   2014.10

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  • 犬猫における腸球菌とレンサ球菌の分離状況と薬剤感受性 Reviewed

    木村 唯、嶋田恵理子、宮本 忠、鳩谷晋吾

    日本獣医師会雑誌 雑誌   67 ( 7 )   499 - 505   2014.07

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  • メチシリン耐性Staphylococcus intermedius groupが分離されたフェレットの1例

    宮本 忠、嶋田恵理子、木村 唯、角本 舞、宮本 明奈、鳩谷晋吾

    動物臨床医学 雑誌   23 ( 2 )   76 - 78   2014.06

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  • 犬猫におけるメチシリン感受性とメチシリン耐性ブドウ球菌感染症の治療成績 Reviewed

    嶋田恵理子、木村 唯、宮本 忠、鳩谷晋吾

    日本獣医師会雑誌 雑誌   67 ( 6 )   426 - 431   2014.06

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  • 犬猫における第三世代セファロスポリン感受性と耐性腸内細菌科細菌感染症の治療成績 Reviewed

    木村 唯、嶋田恵理子、宮本 忠、鳩谷晋吾

    日本獣医師会雑誌 雑誌   67 ( 6 )   419 - 425   2014.06

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  • Evaluation of serum phosphorylated neurofilament subunit NF-H as a prognostic biomarker in dogs with thoracolumbar intervertebral disc herniation Reviewed

    Nishida H(学生), Nakayama M, Tanaka H, Fujita N, Kamishina H, Izawa T, Hatoya S, Sugiura K, Hirai T, , Suzuki Y, Ide C, Inaba T.

    Vet. Surg. 雑誌   43   289 - 293   2014.03

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  • Production of canine soluble CD40 ligand to induce maturation of monocyte derived dendritic cells for cancer immunotherapy Reviewed

    Wijewardana V, Sugiura K, Yahata M(学生), Akazawa T, Wijesekera DPH(学生), Imamoto S(学生), Hatoya S, Inoue N, Inaba T.

    Vet. Immunol. Immunopathol. 雑誌   156 ( 1-2 )   121 - 127   2013.09

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  • Generation of Functional Platelets from Canine Induced Pluripotent Stem Cells Reviewed

    Nishimura T, Hatoya S, Kanegi R, Sugiura K, Wijewardana V, Kuwamura M, Tanaka M, Yamate J, Izawa T, Takahashi M, Kawate N, Tamada H, Imai H, Inaba T.

    Stem Cells Dev. 雑誌   22 ( 14 )   2026 - 2035   2013.07

  • 基質特異性拡張型β‐ラクタマーゼ産生肺炎桿菌による難治性の膀胱炎を発症した犬の1例 Reviewed

    嶋田恵理子、宮本 忠、木村 唯、角本 舞、鳩谷晋吾

    動物臨床医学 雑誌   22 ( 1 )   21 - 25   2013.03

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  • 大阪における犬猫からのメチシリン耐性ブドウ球菌の検出状況と薬剤感受性 Reviewed

    鳩谷晋吾、古家 優、秋吉秀保、谷 浩行、嶋田恵理子、宮本 忠、杉浦喜久弥、稲葉俊夫

    動物臨床医学 雑誌   21 ( 4 )   165 - 169   2013.02

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  • 山口市における犬猫からの2011年臨床分離菌の薬剤感受性 Reviewed

    嶋田恵理子、宮本 忠、木村 唯、角本 舞、鳩谷晋吾.

    動物臨床医学 雑誌   21 ( 4 )   170 - 179   2013.02

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  • Evaluation of methods for cell harvesting and the biological properties at successive passages of canine bone marrow stromal cells Reviewed

    Nishida H, Shoji Y, Nakamura M, Hatoya S, Sugiura K, Yamate J, Kuwamura M, Kotani T, Nakayama M, Suzuki Y, Ide C, Inaba T.

    Am. J. Vet. Res 雑誌   73 ( 11 )   1832 - 1840   2012.11

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  • Insulin-like peptide 3 stimulates testosterone secretion in mouse Leydig cells via cAMP pathway Reviewed

    Pathirana IN, Kawate N, Büllesbach EE, Takahashi M, Hatoya S, Inaba T, Tamada H

    Regulatory Peptides 雑誌   178 ( 1-3 )   102 - 106   2012.10

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  • Three cases of idiopathic sterile pyogranulomatous inflammation of epidural fat in Miniature Dachshunds. Reviewed

    Nishida H, Tanaka H, Kuwamura M, Hatoya S, Sugiura K, Inaba T, Nakayama M

    J Vet Med Sci 雑誌   74 ( 8 )   1071 - 1074   2012.08

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  • メタロhβh ラクタマーゼ産生Acinetobacter lwof fii が分離された犬猫の4 例 Reviewed

    嶋田恵理子、宮本 忠、鳩谷晋吾.

    日本獣医師会雑誌 雑誌   65 ( 5 )   365 - 369   2012.06

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  • Safety of autologous bone marrow stromal cell transplantation in dogs with acute spinal cord injury. Reviewed

    Nishida H, Nakayama M, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Harada Y, Suzuki Y, Ide C, Inaba T.

    Vet Surg 雑誌   41 ( 4 )   437 - 442   2012.05

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  • Plasma insulin-like peptide 3 and testosterone concentrations in male dogs: changes with age and effects of cryptorchidism. Reviewed

    Pathirana IN, Yamasaki H, Kawate N, Tsuji M, Büllesbach EE, Takahashi M, Hatoya S, Inaba T, Tamada H.

    Theriogenology 雑誌   77 ( 3 )   550 - 557   2012.02

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  • 犬猫における臨床材料からのグラム陽性球菌の検出状況と薬剤感受性 Reviewed

    嶋田恵理子、宮本 忠、鳩谷晋吾.

    日本獣医師会雑誌 雑誌   65 ( 2 )   131 - 137   2012.02

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  • Factors associated with patency of the uterine cervix in bitches with pyometra. Reviewed

    Tamada H, Kawata N, Kawate N, Inaba T, Kida K, Hatoya S, Akune A, Nakama K, Kohsaka T, Takahashi M, Sawada T.

    Res Vet Sci. 雑誌   93 ( 3 )   1203 - 1210   2012

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  • 第三世代セファロスポリン耐性Escherichia coliが分離された犬の6例 Reviewed

    嶋田恵理子、宮本 忠、鳩谷晋吾.

    日本獣医師会雑誌 雑誌   65 ( 6 )   452 - 456   2012

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  • 犬猫における臨床材料からのグラム陰性菌の検出状況と薬剤感受性 Reviewed

    嶋田恵理子、宮本 忠、鳩谷晋吾.

    日本獣医師会雑誌 雑誌   64 ( 11 )   879 - 884   2011.11

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  • 犬猫の各種感染症における原因菌とアンチバイオグラム Reviewed

    嶋田恵理子、宮本 忠、鳩谷晋吾.

    日本獣医師会雑誌 雑誌   64 ( 10 )   810 - 815   2011.10

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  • In vitro effects of estradiol-17β, monobutyl phthalate and mono-(2-ethylhexyl) phthalate on the secretion of testosterone and insulin-like peptide 3 by interstitial cells of scrotal and retained testes in dogs. Reviewed

    Pathirana IN, Kawate N, Tsuji M, Takahashi M, Hatoya S, Inaba T, Tamada H.

    Theriogenology 雑誌   76 ( 7 )   1227 - 1233   2011.10

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  • Evaluation of transplantation of autologous bone marrow stromal cells into the cerebrospinal fluid for treatment of chronic spinal cord injury in dogs. Reviewed

    Nishida H, Nakayama M, Tanaka H, Kitamura M, Hatoya S, Sugiura K, Suzuki Y, Ide C, Inaba T.

    Am J Vet Res 雑誌   72 ( 8 )   1118 - 1123   2011.08

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  • Homozygosity of single nucleotide polymorphisms in the 3' region of the canine estrogen receptor 1 gene is greater in Toy Poodles than in Miniature Dachshunds and Chihuahuas. Reviewed

    Pathirana IN, Tanaka K, Kawate N, Tsuji M, Hatoya S, Inaba T, Tamada H.

    Anim Sci J 雑誌   82 ( 3 )   390 - 395   2011.06

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  • Successful Management with CHOP for Pulmonary Lymphomatoid Granulomatosis in a Dog. Reviewed

    Hatoya S, Kumagai D, Takeda S, Yamamoto E, Nakanishi M, Kuwamura M, Sugiura K, Sasai H, Yamate J, Inaba T.

    J. Vet. Med. Sci 雑誌   73 ( 4 )   527 - 530   2011.04

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  • Comparison of testosterone and insulin-like peptide 3 secretions in response to human chorionic gonadotropin in cultured interstitial cells from scrotal and retained testes in dogs Reviewed

    Pathirana IN, Ashida Y, Kawate N, Tanaka K, Makoto T, Takahashi M, Hatoya S, Inaba T, Tamada H.

    Anim. Reprod. Sci 雑誌   57 ( 2 )   267 - 272   2011

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  • Induction of fertile oestrus in dioestrous bitches by prostaglandin F2α and a GnRH-agonist Reviewed

    Ohmura M, Torii R, Hatoya S, Sugiura K, Tamada H, Kawate N, Takahashi M, Sawada T, Inaba T

    Vet. Rec. 雑誌   168 ( 25 )   2011

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  • Detection of relaxin mRNA in the corpus luteum, uterus, and uterine cervix in the bitch Reviewed

    Tamada H, Kawate N, Kawata N, Inaba T, Kida K, Hatoya S, Akune A, Nakama K, Kohsaka T, Sawada T.

    J. Vet. Med. Sci 雑誌   72 ( 10 )   1383 - 1386   2010.10

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  • Effect of IL-12 on the canine dendritic cell maturation following differentiation induced by granulocyte-macrophage CSF and IL-4 , Reviewed

    Sugiura K, Wijewardana V, Fujimoto M, Akazawa T, Yahata M, Mito K, Hatoya S, Inoue N, Inaba T

    Vet. Immunol. Immunopathol 雑誌   137 ( 3-4 )   322 - 326   2010.10

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  • Effect of interferon-gamma on immune and clinical responses in dendritic cell-based immunotherapy against cancer Reviewed

    Mit K, Sugiura K, Ueda K, Hori T, Akazawa T, Yamate J, Hatoya S, Inaba M, Inoue N, Ikehara S, Inaba T.

    Cancer Res 雑誌   70 ( 18 )   7093 - 7101   2010.09

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  • Analysis of Single Nucleotide Polymorphisms in the 3' Region of the Estrogen Receptor 1 Gene in Normal and Cryptorchid Miniature Dachshunds and Chihuahuas Reviewed

    Pathirana IN, Tanaka K, Kawate N, Tsuji M, Kida K, Hatoya S, Inaba T, Tamada H.

    J. Reprod. Dev 雑誌   56 ( 4 )   405 - 410   2010.08

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  • 犬猫由来メチシリン耐性ブドウ球菌の新しい抗菌薬に対する薬剤感受性 Reviewed

    宮本 忠、嶋田恵理子、本田真理、石井 遥、後藤 慈、鳩谷晋吾.

    動物臨床医学 雑誌   19 ( 2 )   63 - 66   2010.06

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  • Epidermal growth factor, transforming growth factor-alpha, and epidermal growth factor receptor expression and localization in the canine endometrium during the estrous cycle and in bitches with pyometra. Reviewed

    Kida K, Maezono Y, Kawate N, Inaba T, Hatoya S, Tamada H.

    Theriogenology 雑誌   73 ( 1 )   36 - 47   2010.01

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    Kind of work:Joint Work  

  • メチシリン耐性Staphylococcus intermedius groupとコアグラーゼ陰性Staphylococcus属の急増と薬剤感受性 Reviewed

    宮本 忠、嶋田恵理子、脇本美保、石井 遥、鳩谷晋吾.

    動物臨床医学 雑誌   18 ( 4 )   101 - 104   2009.12

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    Kind of work:Joint Work  

  • Canine oocyte maturation in culture: Significance of estrogen and EGF receptor gene expression in cumulus cells Reviewed

    Hatoya, S., Sugiyama, Y., Nishida, H., Okuno, T., Torii, R., Sugiura, K., Kida, K., Kawate, N., Tamada, H., Inaba, T

    Theriogenology 雑誌   71 ( 4 )   560 - 567   2009.03

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    Kind of work:Joint Work  

  • Construction of an expression vector for improved secretion of canine IL-18 Reviewed

    Sugiura, K., Akazawa, T., Fujimoto, M., Wijewardana, V., Mito, K., Hatoya, S., Taketani, S., Komori, M., Inoue, N., Inaba, T

    Vet. Immunol. Immunopathol 雑誌   126 ( 3月4日 )   388 - 391   2008.12

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    Kind of work:Joint Work  

  • Reduction of mucin-1 gene expression associated with increased Escherichia coli adherence in the canine uterus in the early stage of dioestrus Reviewed

    Ishiguro, K., Baba, E., Torii, R., Tamada, H., Kawate, N., Hatoya, S., Wijewardana, V., Kumagai, D., Sugiura, K., Sawada, T., Inaba, T

    Vet. J 雑誌   173 ( 2 )   325 - 332   2007.03

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    Kind of work:Joint Work  

  • Generation of canine dendritic cells from peripheral blood monocytes without using purified cytokines Reviewed

    Wijewardana,V., Sugiura,K., Oichi, T., Fujimoto, M., Akazawa, T., Hatoya, S., Inaba, M., Ikehara, S., Jayaweera, T.S.P., Inaba, T

    Vet. Immunol. Immunopathol 雑誌   114 ( 1月2日 )   37 - 48   2006.11

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    Kind of work:Joint Work  

  • Lactoferrin expression in the canine uterus during the estrous cycle and with pyometra Reviewed

    Kida, K., Baba, E., Torii, R., Kawate, N., Hatoya, S., Wijewardana, V., Sugiura, K., Sawada, T., Tamada, H., Inaba, T

    Theriogenology 雑誌   66 ( 5 )   1325 - 1333   2006.09

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    Kind of work:Joint Work  

  • Effect of co-culturing with embryonic fibroblasts on IVM, IVF and IVC of canine oocytes Reviewed

    Hatoya,S.,Sugiyama, Y.,Torii,R., Wijewardana,V.,Kumagai,D.,Sugiura,K.,Kida, K.,Kawate,N.,Tamada, H.,Sawada,T., Inaba, T

    Theriogenology 雑誌   66 ( 5 )   1083 - 1090   2006.09

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    Kind of work:Joint Work  

  • Induction of fertile oestrus in bitches by an intranasal spray of gonadotrophin-releasing hormone agonist. Reviewed

    Hatoya S, Torii R, Wijewardana V, Kumagai D, Sugiura K, Kawate N, Tamada H, Sawada T, Inaba T.

    Vet Rec 雑誌   158 ( 11 )   378 - 379   2006.03

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    Kind of work:Joint Work  

  • Isolation and characterization of embryonic stem-like cells from canine blastocysts. Reviewed

    Hatoya S, Torii R, Kondo Y, Okuno T, Kobayashi K, Wijewardana V, Kawate N, Tamada H, Sawada T, Kumagai D, Sugiura K, Inaba T.

    Mol Reprod Dev. 雑誌   73 ( 3 )   298 - 305   2006.03

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    Kind of work:Joint Work  

  • Effect of ovarian hormones on periodical changes in immune resistance associated with estrous cycle in the beagle bitch Reviewed

    Sugiura、K., Nishikawa, M., Ishiguro, K., Tajima, T., Inaba, M., Torii, R., Hatoya, S., Wijewardana, V., Kumagai, D., Tamada, H., Sawada, T., Ikehara, S., Inaba, T

    Immunobiology 雑誌   209 ( 8 )   619 - 627   2004.12

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    Kind of work:Joint Work  

  • Expression of estrogen receptor alpha and beta genes in the mediobasal hypothalamus, pituitary and ovary during the canine estrous cycle. Reviewed

    Hatoya S, Torii R, Kumagai D, Sugiura K, Kawate N, Tamada H, Sawada T, Inaba T.

    Neurosci Lett. 雑誌   347 ( 2 )   131 - 135   2003.08

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    Kind of work:Joint Work  

  • Enhancement of aromatase gene expression in the mediobasal hypothalamus during anestrus in the beagle bitch Reviewed

    Inaba, T., Namura, T,Tani, H., Matsuyama, S., Torii, R., Kawate, N., Tamada, H., Hatoya, S, Kumagai, D., Sugiura, K., Sawada, T

    Neurosci. Lett. 雑誌   333 ( 2 )   107 - 110   2002.11

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    Kind of work:Joint Work  

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Books and Other Publications

  • とある臨床現場を覗いて学ぶ 犬と猫の初期診療アプローチ

    鳩谷晋吾 他( Role: Joint author)

    緑書房  2021.10 

  • 犬と猫の耳鼻咽頭疾患(訳書)

    鳩谷晋吾、谷浩行、古家優 他( Role: Joint author)

    緑書房  2020.05 

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    Responsible for pages:49-86、101-127  

  • 獣医再生医療 基礎&ステップアップ

    鳩谷晋吾 他( Role: Joint author)

    インターズー  2019.02 

  • 小動物の臨床栄養学(訳書)

    鳩谷晋吾、谷浩行、古家優 他( Role: Joint author)

    マークモーリス研究所  2014.03 

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    Responsible for pages:1031-1070  

MISC

  • 理解を深める内分泌疾患の基礎と臨床(第23回)(最終回) 副腎の腫瘍

    金城 綾二, 鳩谷 晋吾

    CAP: Companion Animal Practice   39 ( 3 )   73 - 84   2024.03( ISSN:0913-5316

  • 理解を深める内分泌疾患の基礎と臨床(第20回) 副腎皮質機能亢進症(2) International journal

    鍋谷知代、鳩谷晋吾

    CAP: Companion Animal Practice   39 ( 1 )   47 - 55   2024.01

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    Authorship:Last author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:Domestic journal  

  • 理解を深める内分泌疾患の基礎と臨床(第19回) 副腎皮質機能亢進症(1) International journal

    鳩谷晋吾

    CAP: Companion Animal Practice   38 ( 12 )   65 - 73   2023.12

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:Domestic journal  

  • 【ネコのズーロジー-ネコをめぐる科学研究と社会問題】iPS細胞・ES細胞を活用したネコ獣医療への応用 研究の現状と今後の展望 International journal

    鳩谷 晋吾

    遺伝: 生物の科学   77 ( 2 )   130 - 137   2023.03( ISSN:0387-0022

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:Domestic journal  

  • 理解を深める内分泌疾患の基礎と臨床(第9回) 原発性上皮小体機能亢進症(2) International journal

    鳩谷 晋吾

    CAP: Companion Animal Practice   37 ( 12 )   48 - 54   2022.12( ISSN:0913-5316

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:Domestic journal  

  • 理解を深める内分泌疾患の基礎と臨床(第8回) 原発性上皮小体機能亢進症(1) International journal

    鳩谷 晋吾

    CAP: Companion Animal Practice   37 ( 11 )   36 - 42   2022.11( ISSN:0913-5316

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:International journal  

  • 【二次診療に紹介する前に!見逃しやすいこんな異常・疾患】内分泌疾患 副腎腫瘍が原因となる副腎皮質機能亢進症 International journal

    岡田 久功, 金城 綾二, 鳩谷 晋吾

    CAP: Companion Animal Practice   37 ( 7 )   27 - 37   2022.07( ISSN:0913-5316

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:Domestic journal  

  • 【まるごと一冊 犬と猫の再生医療】犬と猫のiPS細胞 International journal

    鳩谷 晋吾

    MVM   31 ( 3 )   65 - 74   2022.04

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    Authorship:Lead author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:International journal  

  • 血液細胞からのイヌiPS細胞作製

    鳩谷 晋吾

    バイオサイエンスとインダストリー   79 ( 4 )   306 - 307   2021.07( ISSN:0914-8981

  • ■私の心に残るあの症例  「IBD? 高分化型リンパ腫? 病理・クローナリティ検査を再考する転機となった2症例」

    鳩谷晋吾

    CAP   2021.01

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  • 私の心に残るあの症例(第10回) IBD?高分化型リンパ腫?病理・クローナリティ検査を再考する転機となった2症例 International journal

    鳩谷 晋吾

    CAP: Companion Animal Practice   36 ( 1 )   84 - 92   2021.01( ISSN:0913-5316

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)   Kind of work:Single Work   International / domestic magazine:Domestic journal  

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Presentations

  • 再生医学と再生獣医学の接点~獣医学におけるiPS細胞研究の進展と応用への展開~ Domestic conference

    鳩谷晋吾

    第23回日本再生医療学会総会  2024.03  日本再生医療学会

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    Venue:新潟  

  • 〔シンポジウム〕 小動物 動物病院における安全管理体制を どのように整備するか~インシデントと アクシデントの予防と共有~ 大学附属獣医臨床センターにおける安全管理体制 Invited Domestic conference

    鳩谷晋吾

    第41回日本獣医師会獣医学術学会年次大会(令和5年度)  2023.12  日本獣医師会

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    Presentation type:Symposium, workshop panel (nominated)  

    Venue:神戸市  

  • Red Blood Cell Differentiation from Multiple Cell Types-Derived Canine Induced Pluripotent Stem Cell International conference

    Kazuto Kimura, Masaya Tsukamoto, Miyuu Tanaka, Mitsuru Kuwamura, Genki Ishihara, Mahito Nakanishi, Kikuya Sugiura, Shingo Hatoya

    NAVRMA 2023 Conference  2023.09  North American Veterinary Regenerative Medicine Association

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    Presentation type:Oral presentation (general)  

    Venue:America, Hawaii.  

  • Developing Canine Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Dilated Cardiomyopathy Disease Modeling in Doberman Pinschers International conference

    Kazuto Kimura, Maria Questa, Joshua Stern, Shingo Hatoya, Amir Kol

    NAVRMA 2023 Conference  2023.09  North American Veterinary Regenerative Medicine Association

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    Presentation type:Poster presentation  

    Venue:America, Hawaii.  

  • 【初心に帰るシリーズ】 貧血を分類してみよう Invited Domestic conference

    鳩谷晋吾

    WJVF(West Japan Veterinary Fourm) 2023 第14回大会  2023.07  一般社団法人 日本臨床獣医学フォーラム

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪  

  • 【ステロイドなど免疫抑制剤を使う疾患シリーズ】 消化器 Invited Domestic conference

    鳩谷晋吾

    WJVF(West Japan Veterinary Fourm) 2023 第14回大会  2023.07  一般社団法人 日本臨床獣医学フォーラム

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:大阪  

  • 獣医内科系疾患に対する再生医療への期待 Invited Domestic conference

    鳩谷晋吾

    日本獣医再生医療学会第19回年次大会  2023.05  日本獣医再生医療学会

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    Presentation type:Public lecture, seminar, tutorial, course, or other speech  

    Venue:横浜市  

  • イヌiPS細胞を用いた赤血球系譜への分化誘導 Invited Domestic conference

    木村和人, 塚本雅也,田中美有,桑村充,石原玄基,中西真人,杉浦喜久弥,鳩谷晋吾

    日本獣医再生医療学会第19回年次大会  2023.05  日本獣医再生医療学会

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    Presentation type:Poster presentation  

    Venue:横浜市  

  • シンポジウム「獣医再生医療研究の最前線~one health貢献への期待と課題~」:「イヌiPS細胞の作製と今後の課題」 Invited Domestic conference

    鳩谷 晋吾

    第22回日本再生医療学会総会  2023.03  日本再生医療学会

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    Presentation type:Symposium, workshop panel (public)  

    Venue:京都  

  • 輸血への応用に向けた赤芽球由来イヌiPS細胞の作製と赤血球への分化誘導 Domestic conference

    木村和人, 塚本雅也,田中美有,桑村充,石原玄基,中西真人,杉浦喜久弥,鳩谷晋吾

    第19回日本獣医内科学アカデミー学術大会  2023.02  日本獣医内科学アカデミー

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    Presentation type:Oral presentation (general)  

    Venue:東京 および web開催 併用  

  • イヌiPS細胞の安定的かつ効率的なフィーダーフリー培養条件の検討 Domestic conference

    長倉京哉、塚本雅也、木村和人、杉浦喜久弥、鳩谷晋吾

    第165回日本獣医学会学術集会  2022.09  日本獣医学会

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    Presentation type:Oral presentation (general)  

    Venue:web開催  

  • 樹状細胞の活性と機能を特異的に増強するアジュバントによる腫瘍免疫治療効果の検討 Domestic conference

    渡邊 駿一、弓場 英司、赤澤 隆、鳩谷 晋吾、金城 綾二、稲葉 俊夫、杉浦 喜久弥

    第165回日本獣医学会学術集会  2022.09  日本獣医学会

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    Presentation type:Oral presentation (general)  

    Venue:web開催  

  • 「獣医間葉系幹細胞療法の開発と実用化に向けて ~犬猫のADSC療法の臨床研究の集積と貢献~」 犬猫において再生医療が適応となる疾患について Invited Domestic conference

    鳩谷 晋吾

    第21回日本再生医療学会総会  2022.03  日本再生医療学会

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    Presentation type:Symposium, workshop panel (public)  

    Venue:web開催  

  • Manipulation of tumor microenvironment by cytokine-gene transfection elicits therapeutic effects in a visceral tumor model Domestic conference

    WATANABE Shunichi, YUBA Eiji, HATOYA Shingo, INABA Toshio, SUGIURA Kikuya

    第50回日本免疫学会学術集会  2021.12 

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    Presentation type:Poster presentation  

  • 腫瘍微小環境へのサイトカイン遺伝子導入操作は内臓腫瘍モデルにおいて治療効果を発揮する(Manipulation of tumor microenvironment by cytokinegene transfection elicits therapeutic effects in a visceral tumor model) Domestic conference

    Watanabe Shunichi, Yuba Eiji, Hatoya Shingo, Inaba Toshio, Sugiura Kikuya

    日本免疫学会総会・学術集会記録  2021.11  (NPO)日本免疫学会

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    Presentation type:Poster presentation  

  • 犬の慢性腸症における血中マグネシウム濃度と病態との関連 Domestic conference

    酒居幸生, 鳩谷晋吾, 古家 優, 島村俊介, 鍋谷知代, 谷浩行, 嶋田照雅

    日本ペット栄養学会第22回定例大会   2021.10 

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    Presentation type:Poster presentation  

  • 犬の慢性腸症と消化器型リンパ腫を判別するアミノインデックスの構築 Domestic conference

    酒居幸生、古家 優、鳩谷晋吾、島村俊介、鍋谷知代、金城綾二、谷 浩行、嶋田照雅

    日本ペット栄養学会第22回定例大会  2021.10 

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    Presentation type:Poster presentation  

  • ネコ体外胚産生法の低コスト化および簡易化の検討 Domestic conference

    吉田 拓海、辻本 恭典、木村 和人、杉浦 喜久弥、鳩谷 晋吾

    第164回日本獣医学会学術集会  2021.09 

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    Presentation type:Poster presentation  

  • 「腎臓再生へのニューテクノロジー」iPS細胞研究と異種移植研究の融合は、猫の慢性腎不全に対する移植医療を実現できるのか?  猫iPS細胞開発の現状と未来    Invited Domestic conference

    鳩谷晋吾

    第164回日本獣医学会学術集会  2021.09 

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    Presentation type:Oral presentation (invited, special)  

  • サイトカイン遺伝子の腫瘍細胞への導入による微小環境内免疫状態の改変がもたらす治療効果の検討 Domestic conference

    渡邊 駿一、高木 彩夏、弓場 英司、桑村 充、井澤 武史、鳩谷 晋吾、金城 綾二、稲葉 俊夫、杉浦 喜久弥

    第164回日本獣医学会学術集会  2021.09 

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    Presentation type:Poster presentation  

  • 低酸素環境を標的とした犬の消化管型リンパ腫に対する新たな治療法の開発;マウスモデルによる前臨床試験 Domestic conference

    山崎 裕毅、西田 英高、鳩谷 晋吾、秋吉 秀保

    第164回日本獣医学会学術集会  2021.09 

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    Presentation type:Poster presentation  

  • イヌiPS細胞から間葉系幹細胞の誘導の試み Domestic conference

    塚本雅也、川端千晶、木村和人、杉浦喜久弥、鳩谷晋吾

    第164回日本獣医学会学術集会  2021.09 

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    Presentation type:Poster presentation  

  • 末梢血単核球を用いた効率的なイヌiPS細胞の樹立および大量培養 Domestic conference

    木村和人、塚本雅也、吉田拓海、田中美有、桑村充、大高真奈美、西村健、中西真人、杉浦喜久弥、鳩谷晋吾

    第164回日本獣医学会学術集会  2021.09 

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    Presentation type:Poster presentation  

  • 低酸素環境を標的とした犬の消化管型リンパ腫に対する新たな治療法の開発;マウスモデルによる前臨床試験 Domestic conference

    山崎 裕毅, 西田 英高, 鳩谷 晋吾, 秋吉 秀保

    日本獣医学会学術集会講演要旨集  2021.09  (公社)日本獣医学会

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    Presentation type:Oral presentation (general)  

  • 臨床免疫検討会 間葉系幹細胞による治療は難治性疾患の画期的な治療なのか? Invited Domestic conference

    Thierry Olivry、小林哲郎、田村勝利、鳩谷晋吾、福田威、水野拓也

    獣医アトピー・アレルギー・免疫学会 第13回ベーシックセミナー  2021.08 

  • ACNUをレスキュー療法に用いた大細胞性リンパ腫の猫の6例 Domestic conference

    酒居幸生、鳩谷晋吾、古家優、鍋谷知代、金城綾二、島村俊介、谷浩行、嶋田照雅

    日本獣医臨床病理学会 2O21 年次大会  2021.08 

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    Presentation type:Poster presentation  

  • CHEMICALLY-DEFINED AND FEEDER-FREE MAINTENANCE OF CANINE INDUCED PLURIPOTENT STEM CELLS International conference

    K Kimura, M Tsukamoto, T Yoshida, Miyuu Tanaka, Mitsuru Kuwamura, M Ohtaka, K Nishimura, M Nakanishi, K Sugiura, S Hatoya

    ISSCR 2021 Virtual  2021.06 

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    Presentation type:Poster presentation  

  • DIFFERENTIATION OF CANINE INDUCED PLURIPOTENT STEM CELLS INTO DEFINITIVE ENDODERM International conference

    M Tsukamoto, K Kimura, K Sugiura, S Hatoya

    ISSCR 2021 Virtual  2021.06 

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    Presentation type:Poster presentation  

  • 3D培養を用いた犬のグリオーマ細胞の低酸素環境における悪性化機構の解析

    山崎 裕毅, 山田 昭彦, 伊藤 敏生, 西田 英高, 鳩谷 晋吾, 秋吉 秀保

    日本獣医学会学術集会講演要旨集  2019.08  (公社)日本獣医学会

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Industrial Property Rights

  • イヌiPS細胞の製造方法

    稲葉俊夫、西村俊哉、田中恵里菜、鳩谷晋吾、杉浦喜久弥

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    property_type:Patent 

  • イヌ人工誘導胚体外内胚葉細胞様株の作製方法

    稲葉敏夫、畦崎直哉、西村俊哉、鳩谷晋吾、杉浦喜久弥

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    property_type:Patent 

  • イヌiPS細胞の作製方法

    稲葉俊夫、西村俊哉、鳩谷晋吾、杉浦喜久弥、桑村 充、山手丈至、井澤武史

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    property_type:Patent 

  • イヌ由来胚性幹細胞、その生産方法、及びその継代培養方法

    稲葉俊夫、鳩谷晋吾、鳥居隆三、杉浦喜久弥、熊谷大二郎

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    property_type:Patent 

Outline of collaborative research (seeds)

  • イヌやネコiPS細胞を用いた再生医療研究

Grant-in-Aid for Scientific Research

  • Generation of feline pluripotent stem cell-derived renal progenitors and kidney organoids for the treatment of chronic kidney disease.

    Grant-in-Aid for Scientific Research(B)  2025

  • Generation of feline pluripotent stem cell-derived renal progenitors and kidney organoids for the treatment of chronic kidney disease.

    Grant-in-Aid for Scientific Research(B)  2024

  • 臨床グレードの犬のiPS細胞を用いた運動器再生医療の確立

    Grant-in-Aid for Scientific Research(B)  2022.04

  • 慢性腎臓病治療に向けたネコ多能性幹細胞由来腎前駆細胞および腎オルガノイドの作製

    Grant-in-Aid for Scientific Research(B)  2022.04

  • 腫瘍微小環境の理解に基づく効果的な治療法の開発

    Grant-in-Aid for Scientific Research(B)  2022.04

  • 細胞競合ニッチを用いたイヌiPS細胞由来全尿路系臓器の誘導

    Grant-in-Aid for Scientific Research(B)  2022.04

  • イヌiPS細胞由来間葉系幹細胞を用いた難治性疾患治療薬の開発

    Grant-in-Aid for Scientific Research(B)  2021

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Original item・Special report (Research Activity)

  • 2024

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    Original item:2024年度発行の統合報告書 アニュアルレポート に掲載

    Special report:公立大学法人大阪 統合報告書(Annual Report 2024)の研究トピックで、イヌiPS細胞研究が紹介された

  • 2023

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    Original item:犬の尿由来iPS細胞の作製について、論文(stem cell reports)がプレスリリースされ、非常に多くの新聞等メディアに紹介された

    Special report:発表論文 Stem Cell Reports. 2024;19(1):141-157.
    doi: 10.1016/j.stemcr.2023.11.010.

Charge of on-campus class subject

  • 小動物基礎臨床実習

    2024   Intensive lecture   Undergraduate

  • 獣医内科学総論

    2024   Weekly class   Undergraduate

  • 獣医臨床科学特別講義A

    2024   Intensive lecture   Graduate school

  • 先端獣医内科学特論1

    2024   Intensive lecture   Graduate school

  • 獣医科学英語演習

    2024   Intensive lecture   Undergraduate

  • 獣医臨床病理学

    2024   Weekly class   Undergraduate

  • 獣医血液病学

    2024   Weekly class   Undergraduate

  • 先端病態解析学特別講義A

    2024   Intensive lecture   Graduate school

  • 小動物基礎臨床実習

    2022   Intensive lecture   Undergraduate

  • 獣医臨床病理学

    2022   Weekly class   Undergraduate

  • 獣医血液病学

    2022   Weekly class   Undergraduate

  • 獣医科学特別演習1

    2022   Intensive lecture   Graduate school

  • 先端獣医内科学特論1

    2022   Intensive lecture   Graduate school

  • 獣医体験演習

    2022   Weekly class   Undergraduate

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 獣医科学特別演習1

    2022   Intensive lecture   Graduate school

  • 伴侶動物診療学特論

    2022   Intensive lecture   Graduate school

  • 国際・国内インターンシップ

    2022   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 生物学実験獣医

    2022   Intensive lecture   Graduate school

  • 獣医内分泌代謝病学

    2022   Weekly class   Undergraduate

  • 獣医内科学総論

    2022   Weekly class   Undergraduate

  • 獣医内科学実習

    2022   Weekly class   Undergraduate

  • 総合臨床

    2022   Intensive lecture   Undergraduate

  • 臨床基礎実習

    2022   Weekly class   Undergraduate

  • Special Lecture: Advanced Pathobiology A

    2021    

  • Comprehensive Veterinary Clinics

    2021    

  • Fundamental Experiments of Biology

    2021   Practical Training  

  • General Veterinary Internal Medicine

    2021    

  • Topics in Life, Environment, and Advanced Sciences

    2021    

  • Practice in Cell Pathobiology

    2021   Practical Training  

  • Practice in Veterinary Internal Medicine

    2021   Practical Training  

  • Cell Pathobiology B

    2021    

  • Veterinary Endocrinology and Metabolism

    2021    

  • Veterinary Clinical Pathology

    2021    

  • Veterinary Hematology

    2021    

  • Basic clinical practices

    2021   Practical Training  

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Charge of off-campus class subject

  • 特別講義I

    2020.09
    Institution:Kinki University

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    Level:Undergraduate (specialized)  Country:Japan

Number of papers published by graduate students

  • 2023

    Number of graduate students presentations:2

Number of instructed thesis, researches

  • 2023

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (letter term):3

    [Number of doctoral thesis reviews] (chief):[Number of doctoral thesis reviews] (vice-chief):2

Social Activities ⇒ Link to the list of Social Activities

  • 2023年度大阪府獣医師会 症例発表練習会 アドバイザー

    Role(s): Consultant

    Type: Seminar, workshop

    大阪府獣医師会   2023.10

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    2021年度大阪府獣医師会 症例発表練習会でアドバイザーを務めた

  • 【西宮市開業獣医師会】講習会

    Role(s): Lecturer

    Type: Seminar, workshop

    西宮市開業獣医師会  2023.02

  • 2022年度大阪府獣医師会 症例発表練習会 アドバイザーおよびショートレクチャー

    Role(s): Lecturer, Consultant

    Type: Seminar, workshop

    大阪府獣医師会   2022.11

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    2021年度大阪府獣医師会 症例発表練習会でアドバイザーを務めた

  • 第1回OPU-VMC WEBセミナー 明日からできる貧血診断の考え方 鉄剤って必要?(鳩谷 晋吾)

    2021.04 - 2022.03

  • 第13回 OPU-VMCセミナー これってクッシング?〜私たちが悩んだクッシング症候群症例の診断と治療(鳩谷晋吾 ほか:獣医臨床センター/内科診療科)

    2019.04 - 2020.03

  • 第10回 OPU-VMCセミナー 悩ましい!?慢性腸症と消化器型リンパ腫の鑑別診断と治療

    2018.04 - 2019.03

  • 第2回 OPU-VMCセミナー 明日からできる貧血診断の考え方:鉄剤って必要?

    2017.04 - 2018.03

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Media Coverage

  • 世界首次!大阪公立大学等成功从犬尿源细胞中稳定制造出iPS细胞 Internet

    JST アジア・太平洋総合研究センター運営の 中国語のニュースサイト  客観日本  2024.01

  • 大阪公立大など、イヌの尿中細胞からフィーダーフリーでiPS細胞の作製に成功 Internet

    日経バイオテク  web  2023.12

  • イヌの尿由来細胞からのiPS細胞安定作製に成功 Internet

    文永堂出版  JVM NEWS  2023.12

  • フィーダーフリー実現 大阪公立大学など イヌiPS細胞作製で Newspaper, magazine

    化学工業日報  3面  2023.12

  • イヌiPS細胞効率作製 大阪公立大など、尿を使用 Newspaper, magazine

    日経新聞  夕刊11面  2023.12

  • イヌのiPS細胞作製 大阪公立大 尿由来細胞など利用 Newspaper, magazine

    日刊工業新聞  29面  2023.12

  • イヌの尿からiPS細胞 Newspaper, magazine

    読売新聞  夕刊8面  2023.12

  • イヌの尿からiPS細胞を高効率で作製 大阪公立大など世界初の手法 獣医療での再生医療の促進に期待 Internet

    読売テレビニュース  web  2023.12

  • イヌの尿からiPS細胞効率作製 将来の治療応用に期待 Newspaper, magazine

    共同通信  web  2023.12

  • イヌの尿からiPS細胞作製 手法確立、研究進展に期待―大阪公立大など Newspaper, magazine

    時事通信  web  2023.12

  • The future of canine stem cell therapy: unprecedented, painless, and feeder-free Internet

    EurekAlert!  2023.12

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    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載されたことが、アメリカの科学振興協会(AAAS)のオンラインニュースサイト「EurekAlert!」で紹介された。

  • The future of canine stem cell therapy: unprecedented, painless, and feeder-free Internet

    AsiaResearchNews  2023.12

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    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載されたことが、アメリカの科学振興協会(AAAS)のオンラインニュースサイト「EurekAlert!」で紹介された。

  • The future of canine stem cell therapy: unprecedented, painless, and feeder-free Internet

    AlphaGalileo  2023.12

      More details

    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載されたことが、アメリカの科学振興協会(AAAS)のオンラインニュースサイト「EurekAlert!」で紹介された。

  • ネコの不妊「注射1回」 Newspaper, magazine

    朝日新聞社  朝日新聞  2023.06

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    SDGs:

  • わんちゃんホンポ

    2021.04

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    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載されたことが、webサイト「わんちゃんホンポ」で紹介された。

  • EurekAlert!

    2021.02

      More details

    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載されたことが、アメリカの科学振興協会(AAAS)のオンラインニュースサイト「EurekAlert!」で紹介された。

  • Asia Research News

    2021.01

      More details

    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載されたことが、オンラインニュースサイト「Asia Research News」で紹介された。

  • 大阪府立大学 ニュース

    2021.01

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    犬の血液細胞からイヌiPS細胞の作製に成功し、論文Stem Cells and Development に掲載された。

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Academic Activities

  • 第41回日本獣医師会獣医学術学会年次大会(令和5年度)  座長

    Role(s): Panel moderator, session chair, etc.

    日本獣医師会  2023.12

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    Type:Academic society, research group, etc. 

  • 日本獣医再生医療学会第18回年次大会 座長

    Role(s): Panel moderator, session chair, etc.

    2023.05

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    Type:Academic society, research group, etc. 

  • ホームタウンミーティング in Winter 2022

    Role(s): Panel moderator, session chair, etc.

    一般社団法人 日本獣医再生医療学会(JSVRM)  2022.12

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    Type:Academic society, research group, etc. 

Original item / Special report (Management administration)

  • 2023

      More details

    Original item:大阪府立大学獣医臨床センター 内科副診療科長

  • 2023

      More details

    Original item:大阪府立大学獣医臨床センター 消化器科診療科長

  • 2022

      More details

    Original item:大阪府立大学獣医臨床センター 内科副診療科長

  • 2022

      More details

    Original item:大阪府立大学獣医臨床センター 消化器科診療科長

  • 2021

      More details

    Original item:大阪府立大学獣医臨床センター 内科副診療科長