Updated on 2023/05/29

写真a

 
Furuya Masaru
 
Organization
Graduate School of Veterinary Science Department of Veterinary Science Associate Professor
School of Veterinary Science Department of Veterinary Science
Title
Associate Professor
Affiliation
Institute of Veterinary Science
Affiliation campus
Rinku Campus

Position

  • Graduate School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - Now

  • School of Veterinary Science Department of Veterinary Science 

    Associate Professor  2022.04 - Now

Degree

  • Ph.D. ( Others ) (   Osaka Prefecture University )

Research Areas

  • Life Science / Veterinary medical science  / 臨床獣医学

  • Life Science / Tumor diagnostics and therapeutics

  • Life Science / Veterinary medical science  / Veterinary Internal Medicine

Research Interests

  • Veterinary Oncology

  • Cancer Immunology

  • Veterinary Internal Medicine

Research subject summary

  • 伴侶動物における新規腫瘍抗原の同定と診断・治療への応用

  • 腫瘍微小環境が抗癌剤耐性獲得に及ぼす影響の解明

Research Career

  • 伴侶動物の悪性腫瘍に発現する特異的抗原の探索とその臨床応用

    腫瘍抗原、腫瘍マーカー、腫瘍免疫療法  Individual

    2009 - Now 

  • The roles of heat shock proteins in canine mammary gland tumor

    Individual

    2011 - Now 

  • 犬のリンパ腫における腫瘍診断マーカーの探索および化学療法耐性獲得機構の解明

    犬、リンパ腫、診断マーカー、化学療法  Individual

    2012 - Now 

  • ニワトリ消化管寄生原虫の感染防御機構の解明

    消化管寄生原虫、宿主細胞侵入  Joint Research in Japan

    2009 - Now 

Professional Memberships

  • 日本癌学会

    2022 - Now

  • Veterinary Cancer Society

    2019 - Now   Overseas

  • 日本免疫治療学会

    2018 - Now

  • 日本野生動物医学会

    2017 - Now   Domestic

  • 日本獣医がん学会

    2010 - Now   Domestic

  • 動物臨床医学会

    2010 - Now   Domestic

  • 大阪府獣医師会

    2002 - Now   Domestic

  • 日本獣医学会

    2002 - Now   Domestic

▼display all

Awards

  • Best Presentation Award

    2019.10   Asian Meeting of Animal Medical Specialties 2019  

  • Best Presentation Award

    2015.11   Asian Meeting of Animal Medical Specialties 2015  

Job Career (off-campus)

  • Colorado State University, Flint Animal Cancer Center 研究員

    2018.12 - 2019.09

  • 国立大学法人大阪大学大学院工学研究科 招聘准教授

    2018.04 - Now

  • 国立大学法人大阪大学大学院工学研究科 招聘研究員

    2015.04 - 2018.03

Education

  • Osaka Prefecture University   Graduate School, Division of Life Science   Veterinary Science   Doctor's Course   Graduated/Completed

    2002.04 - 2006.03

  • Osaka Prefecture University   Faculty of Agriculture   Bachelor's Course   Graduated/Completed

    1996.04 - 2002.03

Papers

  • <scp>Contrast‐enhanced</scp> computed tomography and <scp>cross‐sectional</scp> anatomy of the trunk in the brownbanded bamboo shark ( <i>Chiloscyllium punctatum</i> )

    Takaomi Ito, Toshiyuki Tanaka, Itsuki Kiyatake, Takeshi Izawa, Masaru Furuya, Kazumi Sasai

    Anatomia, Histologia, Embryologia   52 ( 3 )   437 - 447   2023.01( ISSN:0340-2096 ( eISSN:1439-0264

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1111/ahe.12903

    PubMed

    Other URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/ahe.12903

  • Dystrophin-deficient muscular dystrophy in a Toy Poodle with a single base pair insertion in exon 45 of the Duchenne muscular dystrophy gene. Reviewed

    Kosei Sakai, Tomoki Motegi, James Ken Chambers, Kazuyuki Uchida, Hidetaka Nishida, Shunsuke Shimamura, Hiroyuki Tani, Terumasa Shimada, Masaru Furuya

    The Journal of veterinary medical science   84 ( 4 )   502 - 506   2022.04( ISSN:0916-7250

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    A 10-month-old, intact male Toy Poodle was referred for a postural abnormality. Blood biochemical tests revealed a marked increase in plasma creatine phosphokinase (CPK) concentration. The isoenzyme test showed that 99% of serum CPK consisted of CPK-MM. Histopathological evaluation of muscle biopsy samples confirmed scattered degeneration and necrosis of myofibers. Immunohistochemistry for dystrophin showed an absence of staining in muscle cells. Based on these findings, the dog was diagnosed with dystrophin-deficient muscular dystrophy. Whole genome sequencing using genomic DNA extracted from blood revealed a single base pair insertion in exon 45 of the Duchenne muscular dystrophy (DMD) gene. This is the first report on muscular dystrophy in Toy Poodles and identified a novel mutation in the DMD gene.

    DOI: 10.1292/jvms.21-0504

    PubMed

  • Duchenne muscular dystrophy遺伝子のエキソン45における1塩基挿入によるトイプードルのジストロフィン欠損型筋ジストロフィ(Dystrophin-deficient muscular dystrophy in a Toy Poodle with a single base pair insertion in exon 45 of the Duchenne muscular dystrophy gene) Reviewed

    Sakai Kosei, Motegi Tomoki, Chambers James Ken, Uchida Kazuyuki, Nishida Hidetaka, Shimamura Shunsuke, Tani Hiroyuki, Shimada Terumasa, Furuya Masaru

    The Journal of Veterinary Medical Science   84 ( 4 )   502 - 506   2022.04( ISSN:0916-7250

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • ネコの皮膚リンパ管奇形における診断と治療 Reviewed

    岡田 悟, 山田 優樹, 伊從 慶太, 古家 優

    獣医臨床皮膚科   28 ( 1 )   3 - 9   2022.03( ISSN:1347-6416

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    7ヵ月齢の猫が、左後肢足底部からの反復性の出血を主訴に来院した。患部のパンチ生検による病理組織検査より、脈管奇形が示唆された。パンチ生検後に生検部位からの出血が止まらなかったため、電気メスを用いた焼灼処置を行った。出血量は減少したものの、その後も出血は改善と再発を繰り返した。第30病日に造影CT検査を行ったところ、患部周囲の血管新生および血管拡張が認められた。第37病日に止血を目的として、左後肢第4趾と第5趾を断趾した。断趾後の組織を用いた免疫組織化学による病理組織診断の結果、この脈管奇形は皮膚リンパ管奇形と診断された。病理組織学的マージンは確保されていた一方で、術後1ヵ月の肉眼所見では皮膚表面の小嚢胞が少数残存しており、完全切除に至っていない可能性が考えられた。しかし、術後20ヵ月の時点において出血は認められず、日常生活も問題なく送れている。本例は猫で報告の少ない皮膚リンパ管奇形の報告であり、その診断と治療について考察する。(著者抄録)

  • Retrospective evaluation of nimustine use in the treatment of feline lymphoma. Reviewed

    Sakai K, Hatoya S, Furuya M, Nabetani T, Kanegi R, Shimamura S, Tani H, Shimada T.

    Vet Med Sci 雑誌   8 ( 1 )   3 - 8   2022.01

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • Dystrophin-deficient muscular dystrophy in a Toy Poodle with a single base pair insertion in exon 45 of the Duchenne muscular dystrophy gene Reviewed

    Sakai K, Motegi T, Chambers JK, Uchida K, Nishida H, Shimamura S, Tani H, Shimada T, Furuya M

    J Vet Med Sci 雑誌   2022

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    Kind of work:Joint Work  

  • The Establishment of an Optimal Protocol for Contrast-Enhanced Micro-Computed Tomography in the Cloudy Catshark Scyliorhinus torazame. Reviewed

    Ito T, Furuya M, Sasai K

    Journal of aquatic animal health   33 ( 4 )   264 - 276   2021.12( ISSN:0899-7659

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    DOI: 10.1002/aah.10143

    PubMed

  • Retrospective evaluation of nimustine use in the treatment of feline lymphoma Reviewed

    Kosei Sakai, Shingo Hatoya, Masaru Furuya, Tomoyo Nabetani, Ryoji Kanegi, Shunsuke Shimamura, Hiroyuki Tani, Terumasa Shimada

    Veterinary Medicine and Science   8 ( 1 )   3 - 8   2021.10( ISSN:2053-1095 ( eISSN:2053-1095

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1002/vms3.652

    PubMed

    Other URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/vms3.652

  • Canine idiopathic chylothorax: Anatomic characterization of the pre- and postoperative thoracic duct using computed tomography lymphography. Reviewed

    Kanai H, Furuya M, Yoneji K, Hagiwara K, Nukaya A, Kondo M, Aso T, Fujii A, Sasai K.

    62 ( 4 )   429 - 436   2021.06

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • イヌのリンパ球形質細胞性腸炎における低マグネシウム血症が重症度や予後に及ぼす影響(Influence of hypomagnesemia on disease severity and prognosis in dogs with lymphocytic-plasmacytic enteritis)

    酒居 幸生, 鳩谷 晋吾, 古家 優, 島村 俊介, 鍋谷 知代, 谷 浩行, 嶋田 照雅

    ペット栄養学会誌   24 ( 1 )   1 - 13   2021.04( ISSN:1344-3763

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    ヒトの炎症性腸疾患において、血中マグネシウム濃度は一部の患者で低下し、腸炎の重症度と負の相関を示す。ヒトと同様に、イヌのリンパ球形質細胞性腸炎(LPE)においても低マグネシウム血症が認められるが、病態との関連は不明である。そこで本研究では、イヌLPE症例における血中マグネシウム濃度を測定し、腸炎の重症度や予後との関連を検討することを目的とした。病理組織学的にLPEと診断されたイヌ35頭を組み入れた。診断時における腸炎の組織学的重症度(軽度、中等度または重度)、イヌ炎症性腸疾患活動性指標(CIBDAI)、イヌ慢性腸症活動性指標(CCECAI)を評価し、血清中マグネシウム濃度との関連を検討した。また、低マグネシウム血症の有無で症例を2群に分け、診断後の生存期間を比較した。低マグネシウム血症は22頭(63%)で検出された。血中マグネシウム濃度は腸炎の組織学的重症度、CIBDAIおよびCCECAIと負の相関を示した。低マグネシウム血症の有無で症例の生存期間に有意差は認められなかった。以上のことから、イヌLPE症例における血中マグネシウム濃度は腸炎の重症度を反映しており、バイオマーカーとして有用であると考えられた。(著者抄録)

  • Canine idiopathic chylothorax: Anatomic characterization of the pre‐ and postoperative thoracic duct using computed tomography lymphography

    Hiroo Kanai, Masaru Furuya, Kensuke Yoneji, Ken Hagiwara, Aya Nukaya, Motoki Kondo, Toshihide Aso, Ayako Fujii, Kazumi Sasai

    Veterinary Radiology & Ultrasound   2021.03( ISSN:1058-8183 ( eISSN:1740-8261

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1111/vru.12966

    Other URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1111/vru.12966

  • Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan. Reviewed

    Yasugi M, Hatoya S, Motooka D, Matsumoto Y, Shimamura S, Tani H, Furuya M, Mie K, Miyake M, Nakamura S, Shimada T.

    PLoS One 雑誌   16 ( 2 )   2021.02

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • HSP110 expression in canine mammary gland tumor and its correlation with histopathological classification and grade. Reviewed

    Okada S, Furuya M, Fukui-Kaneshige A, Nakanishi H, Tani H, Sasai K.

    Vet Immunol Immunopathol. 雑誌   ( 232 )   2021.02

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    Authorship:Corresponding author   Kind of work:Joint Work   International / domestic magazine:International journal  

  • HSP110 expression in canine mammary gland tumor and its correlation with histopathological classification and grade

    Satoru Okada, Masaru Furuya, Ayano Fukui-Kaneshige, Hitoshi Nakanishi, Hiroyuki Tani, Kazumi Sasai

    Veterinary Immunology and Immunopathology   232   110171 - 110171   2021.02( ISSN:0165-2427

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    DOI: 10.1016/j.vetimm.2020.110171

  • Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan. Reviewed

    Mayo Yasugi, Shingo Hatoya, Daisuke Motooka, Yuki Matsumoto, Shunsuke Shimamura, Hiroyuki Tani, Masaru Furuya, Keiichiro Mie, Masami Miyake, Shota Nakamura, Terumasa Shimada

    PloS one   16 ( 2 )   e0246482   2021

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    The emergence and global spread of extended-spectrum or AmpC β-lactamase (ESBL/AmpC)-producing Enterobacteriaceae in companion animals have led to the hypothesis that companion animals might be reservoirs for cross-species transmission because of their close contact with humans. However, current knowledge in this field is limited; therefore, the role of companion animals in cross-species transmission remains to be elucidated. Herein, we studied ESBL/AmpC-producing Enterobacteriaceae, Escherichia coli in particular, isolated from extraintestinal sites and feces of companion dogs. Whole-genome sequencing analysis revealed that (i) extraintestinal E. coli isolates were most closely related to those isolated from feces from the same dog, (ii) chromosomal sequences in the ST131/C1-M27 clade isolated from companion dogs were highly similar to those in the ST131/C1-M27 clade of human origin, (iii) certain plasmids, such as IncFII/pMLST F1:A2:B20/blaCTX-M-27, IncI1/pMLST16/blaCTX-M-15, or IncI1/blaCMY-2 from dog-derived E. coli isolates, shared high homology with those from several human-derived Enterobacteriaceae, (iv) chromosomal blaCTX-M-14 was identified in the ST38 isolate from a companion dog, and (v) eight out of 14 tested ESBL/AmpC-producing E. coli isolates (i.e., ST131, ST68, ST405, and ST998) belonged to the human extraintestinal pathogenic E. coli (ExPEC) group. All of the bla-coding plasmids that were sequenced genome-wide were capable of horizontal transfer. These results suggest that companion dogs can spread ESBL/AmpC-producing ExPEC via their feces. Furthermore, at least some ESBL/AmpC-producing ExPECs and bla-coding plasmids can be transmitted between humans and companion dogs. Thus, companion dogs can act as an important reservoir for ESBL/AmpC-producing E. coli in the community.

    DOI: 10.1371/journal.pone.0246482

    PubMed

  • Efficacy of en bloc thoracic duct ligation in combination with pericardiectomy by video-assisted thoracoscopic surgery for canine idiopathic chylothorax Reviewed

    Hiroo Kanai, Masaru Furuya, Ken Hagiwara, Aya Nukaya, Motoki Kondo, Toshihide Aso, Ayako Fujii, Kazumi Sasai

    Veterinary Surgery   49 ( S1 )   O102 - O111   2020.06( ISSN:0161-3499 ( eISSN:1532-950X

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    © 2019 The American College of Veterinary Surgeons Objective: To compare the outcomes of pericardiectomy performed with conventional clipping thoracic duct ligation (C-TDL) to those with en bloc thoracic duct ligation (EB-TDL) using video-assisted thoracoscopic surgery (VATS) for canine idiopathic chylothorax. Study design: Retrospective consecutive case series. Animals: Thirteen client-owned dogs with idiopathic chylothorax. Methods: Medical records of dogs treated with pericardiectomy in combination with TDL by VATS without intraoperative contrast were reviewed. Five and seven dogs underwent C-TDL and EB-TDL, respectively, and 11 dogs were evaluated by preoperative and 7- to 10-days-postoperative computed tomography-lymphography (CTLG). No clinical symptoms with absent or minimal pleural effusion was defined as clinical improvement. Long-term remission (LTR) was defined as rapid resolution of pleural effusion and no recurrence for more than 1 year. Anesthesia time, operation time, the duration of hospitalization, and time until pleural effusion resolution were compared. Results: Clinical improvement was achieved in 91.7% of the cases (C-TDL, 4/5; EB-TDL, 7/7), excluding one case of intraoperative death. The LTR rate was significantly higher with EB-TDL (6/7 [85.7%]) than with C-TDL (1/5 [20%]). Anesthesia time, operation time, and time until pleural effusion resolution were significantly better with EB-TDL than with C-TDL. The rates of thoracic ducts visualization by postoperative CTLG were 100% (5/5) with C-TDL and 42.9% (3/7) with EB-TDL. Conclusion: En bloc TDL was an effective treatment for canine idiopathic chylothorax in this patient population. It compared favorably to C-TDL, although missed branches at the time of surgery may explain the difference between C-TDL and EB-TDL in this small population of cases. Clinical significance: En bloc TDL by VATS was an effective minimally invasive treatment for canine idiopathic chylothorax. Computed tomography-lymphography can be used for surgical planning and postoperative evaluation.

    DOI: 10.1111/vsu.13370

    PubMed

  • リンパ球形質細胞性腸炎のイヌにおける血清亜鉛濃度低下、およびその疾患重症度および予後との関連性(Decreased serum zinc concentration in dogs with lymphocytic-plasmacytic enteritis, and its associations with disease severity and prognosis) Reviewed

    Sakai Kosei, Hatoya Shingo, Furuya Masaru, Shimamura Shunsuke, Nabetani Tomoyo, Tani Hiroyuki, Shimada Terumasa

    The Journal of Veterinary Medical Science   82 ( 6 )   759 - 763   2020.06( ISSN:0916-7250

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

  • Decreased serum zinc concentration in dogs with lymphocytic-plasmacytic enteritis, and its associations with disease severity and prognosis. Reviewed

    Kosei Sakai, Shingo Hatoya, Masaru Furuya, Shunsuke Shimamura, Tomoyo Nabetani, Hiroyuki Tani, Terumasa Shimada

    The Journal of veterinary medical science   82 ( 6 )   759 - 763   2020.04( ISSN:0916-7250

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    Human patients with inflammatory bowel disease may have poor prognosis with hypozincemia. However, there are limited data on zinc concentrations in the blood of dogs with lymphocytic-plasmacytic enteritis (LPE). The purpose of this study was to investigate the serum zinc concentration in dogs with LPE and its influence on disease severity and prognosis. Thirty-five dogs with LPE were recruited. Serum zinc concentration was measured using atomic absorption spectrometry. Hypozincemia was observed in 18/35 (51%) dogs with LPE. Serum zinc concentration was inversely correlated with histological and clinical severities. Overall survivals were significantly shorter in dogs with hypozincemia than in those without it. These findings suggest that serum zinc concentration is a useful biomarker for LPE severity and prognosis in dogs.

    DOI: 10.1292/jvms.20-0109

    PubMed

  • 尿管に発生した尿路上皮乳頭腫の犬の1例 Reviewed

    井上 侑花, 平田 翔吾, 田中 美有, 桑村 充, 金城 綾二, 古家 優, 北原 崇, 山崎 裕毅, 飯盛 安真, 三重 慧一郎, 西田 英高, 秋吉 秀保

    日本獣医麻酔外科学雑誌   50 ( Suppl.1 )   306 - 306   2019.06( ISSN:2189-6623 ( eISSN:2189-6631

  • Correlation between toll-like receptor 4 and nucleotide-binding oligomerization domain 2 (NOD2) and pathological severity in dogs with chronic gastrointestinal diseases Reviewed

    Kimiya Aono, Yasu Taka Azuma, Tomoyo Nabetani, Shingo Hatoya, Masaru Furuya, Mariko Miki, Kana Hirota, Yasuyuki Fujimoto, Kazuhiro Nishiyama, Yoshiyuki Ogata, Tomofumi Mochizuki, Hiroyuki Tani

    Veterinary Immunology and Immunopathology   210   15 - 22   2019.04( ISSN:0165-2427 ( eISSN:1873-2534

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    © 2019 Elsevier B.V. Toll-like receptor 4 (TLR4), nucleotide-binding oligomerization domain 2 (NOD2), and TNF-α play important roles in human inflammatory bowel diseases. The aim of this study was to elucidate the relationship between Toll-like receptor 4, NOD2, and TNF-α and the severity of chronic gastrointestinal diseases in dogs. We examined the expression levels of TLR4, NOD2, and TNF-α in the stomach, duodenum, ileum, colon, and rectum obtained from 21 dogs with chronic gastrointestinal disease, including inflammatory bowel disease, high-grade lymphoma, food responsive enteropathy, chronic pancreatitis, low-grade lymphoma, inflammatory colorectal polyp, and chronic colitis. Next, we demonstrated whether there is good correlation between the expression levels of TLR4, NOD2, and TNF-α and the histopathological analysis of each sample. We found that the level of TLR4 expression in the ileum of dogs with chronic gastrointestinal disease was positively associated with the histopathological severity. We also found that the level of NOD2 expression in the duodenum, stomach, and rectum was positively associated with the histopathological severity. However, there was no correlation between TNF-α expression in the 5 regions tested in this study and the histopathological severity. These findings indicate that TLR4 and NOD2 are remarkably associated with the severity of chronic gastrointestinal disease in dogs.

    DOI: 10.1016/j.vetimm.2019.03.003

    PubMed

  • Prevalence of microorganisms associated with feline gingivostomatitis Reviewed

    Hitoshi Nakanishi, Masaru Furuya, Takehisa Soma, Yoshiki Hayashiuchi, Ryusaku Yoshiuchi, Makoto Matsubayashi, Hiroyuki Tani, Kazumi Sasai

    Journal of Feline Medicine and Surgery   21 ( 2 )   103 - 108   2019.02( ISSN:1098-612X ( eISSN:1532-2750

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    Publishing type:Research paper (scientific journal)   Kind of work:Joint Work   International / domestic magazine:International journal  

    © The Author(s) 2018. Objectives: Feline gingivostomatitis (FGS) is a painful chronic inflammatory disease of the oral cavity. The purpose of this study was to examine the frequency of detection of certain common feline bacteria and viruses to determine any potential associations with FGS. Methods: A multicentre case-control study design was conducted. In total, 72 control cats and 32 cats with FGS were included in the study. Oral swabs were cultured for bacterial identification and a PCR assay was carried out to examine the infection of feline calicivirus (FCV), feline herpesvirus-1 (FHV-1), Chlamydia felis, Mycoplasma felis and Bordetella bronchiseptica. Results: There was a significant difference in age distribution between the control and the FGS group. Based on a PCR assay, the positive rate of FCV was significantly higher in FGS cats than control animals. For other infectious pathogens, including FHV-1, C felis and M felis, there was no significant difference. Bacterial culture of oral swabs revealed that Pasteurella multocida was most frequently detected, but the detection rate was significantly lower in FGS cats. In FGS cats, the incidence of Enterococcus faecalis and anaerobic bacteria were more frequently isolated than in control cats. Conclusions and relevance: This study indicates that the positive rate of FCV was significantly higher in cats with FGS, and the microflora of the oral cavity of cats with FGS might be disrupted, although additional studies are required to compare the oral microbiome in cats of a variety of ages.

    DOI: 10.1177/1098612X18761274

    PubMed

  • 【犬の鼻腔腫瘍】骨転移を認めた犬の鼻腺癌の1例

    藤崎 友裕, 和田 悠佑, 金城 綾二, 古家 優, 森山 裕至, 井澤 武史, 桑村 充, 嶋田 照雅, 野口 俊助

    Joncol: Japanese Journal of Veterinary Clinical Oncology   15 ( 1 )   56 - 59   2019.01( ISSN:1880-4640

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    犬の鼻腺癌の転移率は低いといわれており、転移のほとんどは肺とリンパ節に生じる。一方、骨・腎臓・肝臓・皮膚・脳への転移は、わずかに報告されているのみである。本症例では、犬鼻腺癌に対し放射線治療後、トセラニブリン酸塩(以下トセラニブ)を投与した。原発巣のコントロールは比較的良好だったが第250病日に死亡し、左下顎リンパ節・脾臓・上腕骨・腸骨に転移が確認された。トセラニブに対する原発巣と転移巣の反応性の違いの原因として、トセラニブの標的分子の発現の差異が示唆された。(著者抄録)

  • 結腸に発生した肥満細胞腫による腸重積を発症した犬の1例

    鍋谷 知代, 古家 優, 島村 俊介, 谷 浩行, 嶋田 照雅

    動物臨床医学   27 ( 4 )   148 - 152   2019.01( ISSN:1344-6991

     More details

    9歳齢の未去勢フレンチ・ブルドッグが1ヵ月継続する食欲不振と血様下痢を主訴に来院した。超音波検査とCT検査において、結腸に腫瘤状病変が認められ、更にその近位に腸重積が確認された。結腸腫瘤の細胞診検査より肥満細胞腫が疑われ、腫瘤および重積部切除術を実施した。病理組織学的検査結果はKiupelらの2段階分類で高グレード肥満細胞腫であり、また、c-Kit遺伝子の変異は認められなかった。術後、各種抗癌剤と分子標的薬を投与したが奏効せず、診断後約3ヵ月で死亡した。本症例は、結腸の肥満細胞腫により重積を伴った稀な1例である。(著者抄録)

  • Prevalence of micro-organisms associated with feline gingivostomatitis Reviewed

    1. Nakanishi H, Furuya M*, Soma T, Hayashiuchi Y, Yoshiuchi R, Matsubayashi M, Tani H, Sasai K

    J Feline Med Surg 雑誌   21 ( 2 )   103 - 108   2019

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    Kind of work:Joint Work  

  • Outcome of limb fracture repair in rabbits: 139 cases (2007-2015) Reviewed

    2. Sasai H, Fujita D, Seto E, Denda Y, Imai Y, Okamoto K, Okamura K, Furuya M*, Tani H, Sasai K

    J Am Vet Med Assoc 雑誌   252 ( 4 )   457 - 463   2018

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    Kind of work:Joint Work  

  • Report of fatal mixed infection with Cryptosporidium parvum and Giardia intestinalis in neonatal calves Reviewed

    Matsuura Y, Matsubayashi M, Nukata S, Shibahara T, Ayukawa O, Kondo Y, Matsuo T, Uni S, Furuya M, Tani H, Tsuji N, Sasai K

    Acta Parasitol 雑誌   62 ( 1 )   214 - 20   2017

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    Kind of work:Joint Work  

  • Identification of Eimeria acervulina conoid antigen using chicken monoclonal antibody Reviewed

    3. Matsuura Y, Matsubayashi M, Nukata S, Shibahara T, Ayukawa O, Kondo Y, Matsuo T, Uni S, Furuya M, Tani H, Tsuji N, Sasai K

    Parasitol Res 雑誌   115 ( 11 )   4123 - 28   2016

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    Kind of work:Joint Work  

  • A Serological Survey of Leptospira spp., Antibodies in Wild Raccoons (Procyon lotor) in Osaka, Japan Reviewed

    Saeki J, Nakanishi H, Masubuchi K, Matsubayashi M, Furuya M, Tani H, Sasai K

    Asian J Anim Vet Adv 雑誌   11   258 - 62   2016

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    Kind of work:Joint Work  

  • Localization of heat shock protein 110 in canine mammary gland tumors Reviewed

    Okada S, Furuya M*, Takenaka S, Fukui A, Matsubayashi M, Tani H, Sasai K

    Vet Immunol Immunopathol 雑誌   167 ( 3-4 )   139 - 46   2015

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    Kind of work:Joint Work  

  • Characteristics of bone fractures and usefulness of micro-computed tomography for fracture detection in rabbits: 210 cases (2007-2013) Reviewed

    Sasai H, Fujita D, Tagami Y, Seto E, Denda Y, Hamakita H, Ichihashi T, Okamura K, Furuya M*, Tani H, Sasai K, Yamate J

    J Am Vet Med Assoc 雑誌   246 ( 12 )   1339 - 44   2015

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    Kind of work:Joint Work  

  • The detection of toxigenic Corynebacterium ulcerans from cats with nasal inflammation in Japan Reviewed

    7. Saeki J, Katsukawa C, Matsubayashi M, Nakanishi H, Furuya M, Tani H, Sasai K

    Epidemiol Infect 雑誌   143 ( 12 )   2660 - 5   2015

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    Kind of work:Joint Work  

  • Identification of novel tumor-associated antigens in canine mammary gland tumor. Reviewed

    Furuya M, Funasaki M, Tani H, Sasai K.

    Vet Comp Oncol.   13 ( 3 )   194 - 202   2015

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    Kind of work:Joint Work  

  • Profiling of serum metabolites in canine lymphoma using gas chromatography mass spectrometry Reviewed

    Tamai R, Furuya M, Hatoya S, Akiyoshi H, Yamamoto R, Komori Y, Yokoi S, Tani K, Hirano Y, Komori M, Takenaka S.

    J Vet Med Sci 雑誌   76 ( 11 )   1513 - 8   2014

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    Kind of work:Joint Work  

  • Elongation Factor-1α is a Novel Protein Associated with Host Cell Invasion and a Potential Protective Antigen of Cryptosporidium parvum. Reviewed

    Matsubayashi M, Kimata I, Uni S, Lillehoj HS, Matsuda H, Furuya M, Tani H, and Sasai K.

    J Biol Chem.   288 ( 47 )   34111 - 34120   2013

  • Infectivity of Cryptosporidium andersoni Kawatabi type relative to the small number of oocysts in immunodeficient and immunocompetent neonatal and adult mice. Reviewed

    Koyashiki-Nagano S, Matsubayashi M, Kimata I, Furuya M, Tani H, Sasai K.

    Parasitol. Int.   62 ( 2 )   109 - 111   2013

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    Kind of work:Joint Work  

  • Phylogenetic identification of Cystoisospora spp. from dogs, cats, and raccoon dogs in Japan. Reviewed

    Matsubayashi M, Carreno RA, Tani H, Yoshiuchi R, Kanai T, Kimata I, Uni S, Furuya M, Sasai K

    Vet. Parasitol.   176 ( 41673 )   270 - 274   2011

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    Kind of work:Joint Work  

  • Effect of low pH on the morphology and viability of Cryptosporidium andersoni sporozoites and histopathology in the stomach of infected mice. Reviewed

    Matsubayashi M, Ando H, Kimata I, Takase H, Nakagawa H, Furuya M, Tani H, Sasai K

    Int. J. Parasitol.   41 ( 41702 )   287 - 292   2011

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    Kind of work:Joint Work  

  • Survey and molecular characterization of Cryptosporidium and Giardia spp in owned companion animals, dogs and cats in Japan. Reviewed

    Yoshiuch R, Matsubayashi M, Kimata I, Furuya M, Tani H, Sasai K

    Vet. Parasitol.   174 ( 41702 )   313 - 316   2010

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    Kind of work:Joint Work  

  • Morphological changes and viability of Cryptosporidium parvum sporozoites after excystation in cell-free culture media. Reviewed

    Matsubayshi M, Ando H, Kimata I, Nakagawa M, Furuya M, Tani H, Sasai K

    Paratiology   137 ( 13 )   1861 - 1866   2010

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    Kind of work:Joint Work  

  • Inhibition of male chick phenotypes and spermatogenesis by Bisphenol-A. Reviewed

    Furuya M, Adachi K, Kuwahara S, Ogawa K, Tsukamoto Y.

    Life science   78 ( 15 )   767 - 1776   2006

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    Kind of work:Joint Work  

  • Expression of calbindin-D28K in sporadic nephroblastomas of the chicken. Reviewed

    Tsukamoto Y, Tsuchiya AS, Namikawa T, Tatesaki R, Adachi K, Hiroi S, Furuya M, Sari DK, Kotani T.

    Avian Dis.   50 ( 1 )   127 - 130   2006

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    Kind of work:Joint Work  

  • Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde. Reviewed

    Sari DK, Kuwahara S, Furuya M, Tsukamoto Y, Hori H, Kunugita N, Arashidani K, Fujimaki H, Sasaki F.

    J Vet Med Sci.   67 ( 3 )   303 - 309   2005

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    Kind of work:Joint Work  

  • Molecular cloning and analysis of the mouse gicerin gene. Reviewed

    Kohama K, Tsukamoto Y, Furuya M, Okamura K, Tanaka H, Miki N, Taira E

    Neurochem Int.   46 ( 6 )   465 - 470   2005

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    Kind of work:Joint Work  

  • Expression of gicerin enhances the invasive and metastatic activities of a mouse mammary carcinoma cell line. Reviewed

    Tsukamoto Y, Sakaiuchi T, Hiroi S, Furuya M, Tsuchiya S, Sasaki F, Miki N, Taira E.

    Int J Oncol.   23 ( 6 )   1671 - 1677   2003

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    Kind of work:Joint Work  

  • Gicerin, an Ig-superfamily cell adhesion molecule, promotes the invasive and metastatic activities of a mouse fibroblast cell line. Reviewed

    Tsukamoto Y, Egawa M, Hiroi S, Furuya M, Tsuchiya S, Sasaki F, Miki N, Taira E.

    J Cell Physiol.   197 ( 1 )   103 - 109   2003

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    Kind of work:Joint Work  

  • Gicerin, a cell adhesion molecule, promotes the metastasis of lymphoma cells of the chicken. Reviewed

    Tsuchiya S, Tsukamoto Y, Furuya M, Hiroi S, Miki N, Sasaki F, Taira E.

    Cell Tissue Res.   314 ( 3 )   389 - 397   2003

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    Kind of work:Joint Work  

  • Effects of bisphenol-A on the growth of comb and testes of male chicken. Reviewed

    Furuya M, Sasaki F, Hassanin AM, Kuwahara S, Tsukamoto Y.

    Can J Vet Res.   67 ( 1 )   68 - 71   2003

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    Kind of work:Joint Work  

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Books and Other Publications

  • 獣医内科学 第3版

    ( Role: Contributor)

    文英堂  2022.03 

     More details

    Book type:Textbook, survey, introduction

  • 薬用量マニュアル 第5版

    中山智宏, 佐伯潤, 長崎淳一 監修( Role: Joint author)

    学窓社  2021.05 

  • 犬の治療ガイド2020 私はこうしている

    辻本 元, 小山秀一, 大草 潔, 中村篤史 編集( Role: Joint author)

    EDUWARD Press  2020.08 

  • 猫の治療ガイド2020 私はこうしている

    辻本 元, 小山秀一, 大草 潔, 中村篤史 編集( Role: Joint author)

    EDUWARD Press  2020.08 

  • 犬と猫の耳鼻咽喉疾患

    嶋田照雅 監訳

    緑書房  2020.05 

  • 犬と猫の検査・手技ガイド2019 私はこう読む

    辻本 元, 小山秀一, 大草 潔, 兼島 孝, 中村篤史 編集( Role: Joint author)

    EDUWARD Press  2019.04 

  • 薬用量マニュアル 第4版

    中山智宏, 佐伯潤, 長崎淳一 監修( Role: Joint author)

    学窓社  2016.10 

  • 小動物の臨床栄養学 第5版

    岩﨑利郎, 辻本元 監訳( Role: Joint author)

    インターズー  2014.03 

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MISC

  • Metal 3D Printing for Companion Animals

    三重慧一郎, 三重慧一郎, 西田英高, 秋吉秀保, 古家優, 谷浩行, 笹井和美

    スマートプロセス学会誌   10 ( 4 )   2021( ISSN:2186-702X

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  • 犬の慢性腸症における血中マグネシウム濃度と病態との関連 Reviewed International journal

    酒居幸生, 鳩谷晋吾, 古家優, 島村俊介, 鍋谷知代, 谷浩行, 嶋田照雅

    ペット栄養学会誌   24 ( 2 )   2021( ISSN:1344-3763

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    Publishing type:Rapid communication, short report, research note, etc. (scientific journal)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    J-GLOBAL

  • 犬の慢性腸症と消化器型リンパ腫を判別するアミノインデックスの構築

    酒居幸生, 古家優, 鳩谷晋吾, 島村俊介, 鍋谷知代, 金城綾二, 谷浩行, 嶋田照雅

    ペット栄養学会誌   24 ( 2 )   2021( ISSN:1344-3763

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  • Influence of hypomagnesemia on disease severity and prognosis in dogs with lymphocytic-plasmacytic enteritis

    酒居幸生, 鳩谷晋吾, 古家優, 島村俊介, 鍋谷知代, 谷浩行, 嶋田照雅

    ペット栄養学会誌   24 ( 1 )   2021( ISSN:1344-3763

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  • 尿管に発生した尿路上皮乳頭腫の犬の1例 International journal

    井上 侑花, 平田 翔吾, 田中 美有, 桑村 充, 金城 綾二, 古家 優, 北原 崇, 山崎 裕毅, 飯盛 安真, 三重 慧一郎, 西田 英高, 秋吉 秀保

    日本獣医麻酔外科学雑誌   50 ( Suppl.1 )   306 - 306   2019.06( ISSN:2189-6623

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    Publishing type:Research paper, summary (national, other academic conference)   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

  • 臨床試料とペットの大便における抗菌薬耐性菌(Antimicrobial-resistant bacteria in clinical specimens and feces of companion animals)

    安木 真世, 鳩谷 晋吾, 元岡 大祐, 島村 俊介, 谷 浩行, 古家 優, 三重 慧一郎, 三宅 眞実, 中村 昇太, 嶋田 照雅

    日本細菌学雑誌   74 ( 1 )   134 - 134   2019.03( ISSN:0021-4930 ( eISSN:1882-4110

  • 【犬の鼻腔腫瘍】骨転移を認めた犬の鼻腺癌の1例

    藤崎 友裕, 和田 悠佑, 金城 綾二, 古家 優, 森山 裕至, 井澤 武史, 桑村 充, 嶋田 照雅, 野口 俊助

    Joncol: Japanese Journal of Veterinary Clinical Oncology   15 ( 1 )   56 - 59   2019.01( ISSN:1880-4640

     More details

    犬の鼻腺癌の転移率は低いといわれており、転移のほとんどは肺とリンパ節に生じる。一方、骨・腎臓・肝臓・皮膚・脳への転移は、わずかに報告されているのみである。本症例では、犬鼻腺癌に対し放射線治療後、トセラニブリン酸塩(以下トセラニブ)を投与した。原発巣のコントロールは比較的良好だったが第250病日に死亡し、左下顎リンパ節・脾臓・上腕骨・腸骨に転移が確認された。トセラニブに対する原発巣と転移巣の反応性の違いの原因として、トセラニブの標的分子の発現の差異が示唆された。(著者抄録)

  • 結腸に発生した肥満細胞腫による腸重積を発症した犬の1例

    鍋谷 知代, 古家 優, 島村 俊介, 谷 浩行, 嶋田 照雅

    動物臨床医学   27 ( 4 )   148 - 152   2019.01( ISSN:1344-6991 ( eISSN:1881-1574

     More details

    9歳齢の未去勢フレンチ・ブルドッグが1ヵ月継続する食欲不振と血様下痢を主訴に来院した。超音波検査とCT検査において、結腸に腫瘤状病変が認められ、更にその近位に腸重積が確認された。結腸腫瘤の細胞診検査より肥満細胞腫が疑われ、腫瘤および重積部切除術を実施した。病理組織学的検査結果はKiupelらの2段階分類で高グレード肥満細胞腫であり、また、c-Kit遺伝子の変異は認められなかった。術後、各種抗癌剤と分子標的薬を投与したが奏効せず、診断後約3ヵ月で死亡した。本症例は、結腸の肥満細胞腫により重積を伴った稀な1例である。(著者抄録)

  • 尿管に発生した尿路上皮乳頭腫の犬の1例

    井上侑花, 平田翔吾, 田中美有, 田中美有, 桑村充, 金城綾二, 古家優, 古家優, 北原崇, 山崎裕毅, 山崎裕毅, 飯盛安真, 飯盛安真, 三重慧一郎, 三重慧一郎, 西田英高, 西田英高, 秋吉秀保, 秋吉秀保

    日本獣医麻酔外科学雑誌(Web)   50 ( Supplement 1 )   2019( ISSN:2189-6631

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  • イヌの乳腺腫瘍におけるHSP110の発現動態の解析 International journal

    岡田悟, 岡田悟, 古家優, 谷浩行, 笹井和美

    日本獣医学会学術集会講演要旨集   162nd   2019( ISSN:1347-8621

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    Authorship:Corresponding author   Kind of work:Joint Work   International / domestic magazine:Domestic journal  

    J-GLOBAL

  • 薬剤耐性菌伝播におけるキャリアとしての伴侶動物の重要性の評価

    安木真世, 鳩谷晋吾, 元岡大祐, 島村俊介, 谷浩行, 古家優, 三重慧一郎, 三宅眞実, 中村昇太, 嶋田照雅

    日本産業動物獣医学会(近畿)・日本小動物獣医学会(近畿)・日本獣医公衆衛生学会(近畿)   2019   2019

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Presentations

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Outline of collaborative research (seeds)

  • 伴侶動物における腫瘍特異的抗原の探索と診断・治療への応用

Grant-in-Aid for Scientific Research

  • Functional analysis of cancer-associated fibroblast in canine melanoma

    Grant-in-Aid for Scientific Research(C)  2026

  • 犬口腔扁平上皮癌の根治を目指した全身投与可能な核酸療法の確立

    Grant-in-Aid for Scientific Research(B)  2026

  • Functional analysis of cancer-associated fibroblast in canine melanoma

    Grant-in-Aid for Scientific Research(C)  2025

  • 犬口腔扁平上皮癌の根治を目指した全身投与可能な核酸療法の確立

    Grant-in-Aid for Scientific Research(B)  2025

  • Functional analysis of cancer-associated fibroblast in canine melanoma

    Grant-in-Aid for Scientific Research(C)  2024

  • 犬口腔扁平上皮癌の根治を目指した全身投与可能な核酸療法の確立

    Grant-in-Aid for Scientific Research(B)  2024

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Charge of on-campus class subject

  • 獣医内科学総論

    2024   Weekly class   Undergraduate

  • 小動物基礎臨床実習

    2024   Intensive lecture   Undergraduate

  • 獣医臨床栄養学

    2024   Weekly class   Undergraduate

  • 獣医腫瘍学

    2024   Weekly class   Undergraduate

  • 先端獣医内科学特論2

    2024   Intensive lecture   Graduate school

  • 高度医療学特別講義A

    2024   Intensive lecture   Graduate school

  • 獣医科学英語演習

    2024   Intensive lecture   Undergraduate

  • 小動物基礎臨床実習

    2022   Intensive lecture   Undergraduate

  • 獣医臨床栄養学

    2022   Weekly class   Undergraduate

  • 獣医腫瘍学

    2022   Weekly class   Undergraduate

  • 獣医科学特別演習1

    2022   Intensive lecture   Graduate school

  • 臨床基礎実習

    2022   Weekly class   Undergraduate

  • 獣医体験演習

    2022   Weekly class   Undergraduate

  • 獣医科学特別演習1

    2022   Intensive lecture   Graduate school

  • 伴侶動物診療学特論

    2022   Intensive lecture   Graduate school

  • 国際・国内インターンシップ

    2022   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 獣医科学特別研究1

    2022   Intensive lecture   Graduate school

  • 生物学実験

    2022   Intensive lecture   Undergraduate

  • 獣医皮膚病学

    2022   Weekly class   Undergraduate

  • 獣医消化器病学

    2022   Weekly class   Undergraduate

  • 獣医内科学総論

    2022   Weekly class   Undergraduate

  • 獣医内科学実習

    2022   Weekly class   Undergraduate

  • 総合臨床

    2022   Intensive lecture   Undergraduate

  • Special Lecture: Advanced Clinical Medicine A

    2021    

  • Comprehensive Veterinary Clinics

    2021    

  • Veterinary Gastroenterology

    2021    

  • Veterinary Clinical Nutrition

    2021    

  • Fundamental Experiments of Biology

    2021   Practical Training  

  • General Veterinary Internal Medicine

    2021    

  • First Year Seminar

    2021    

  • Practice in Veterinary Internal Medicine

    2021   Practical Training  

  • Practice in Veterinary Internal Medicine

    2021   Practical Training  

  • Veterinary Dermatology

    2021    

  • Basic clinical practices

    2021   Practical Training  

  • Veterinary Oncology

    2021    

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