Updated on 2024/04/18
Graduate School of Science Department of Biological Chemistry
Associate Professor 2022.04 - Now
School of Science Department of Biological Chemistry
Associate Professor 2022.04 - Now
M.biomedical science （ Others ） ( Kobe University )
Ph.D （ Others ） ( Kobe University )
Life Science / Molecular biology / 分子生物学
Life Science / Cell biology / 細胞生物学
Life Science / Cell biology
Life Science / Molecular biology
骨格筋、脂肪細胞、白色脂肪細胞、褐色脂肪細胞、Rac1、GLUT4、CD36、FATP1、低分子量GTP結合タンパク質、グルコース取込み、脂肪酸、インスリン、肥満、糖尿病、NAFLD、脂肪肝、細胞内シグナル伝達、肝臓、ノックアウトマウス
肥満、糖尿病発症におけるRac1の関与
温度刺激応答シグナル伝達機構の解明
脂肪細胞における糖取り込みシグナル伝達機構の解明
骨格筋における糖取り込みシグナル伝達機構の解明
日本生化学会
日本分子生物学会
Insulin-stimulated translocation of the fatty acid transporter CD36 to the plasma membrane is mediated by the small GTPase Rac1 in adipocytes Reviewed
Man Piu Chan, Nobuyuki Takenaka, Yuki Abe, Takaya Satoh
cell signaling 2024.02
Impaired insulin signaling mediated by the small GTPase Rac1 in skeletal muscle of the leptin-deficient obese mouse. M. P. Chan, N. Takenaka, T. Satoh. Reviewed
M. P. Chan, N. Takenaka, T. Satoh.
International Journal of Molecular Sciences 24 ( 14 ) 2023.07
Hasegawa K.
International Journal of Molecular Sciences 24 ( 5 ) 2023.03（ ISSN:16616596 ）
Atrophy of White Adipose Tissue Accompanied with Decreased Insulin-Stimulated Glucose Uptake in Mice Lacking the Small GTPase Rac1 Specifically in Adipocytes. Reviewed
Kiko Hasegawa, Nobuyuki Takenaka, Kenya Tanida, Man Piu Chan, Mizuki Sakata, Atsu Aiba, Takaya Satoh
International journal of molecular sciences 22 ( 19 ) 2021.10
The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling. Reviewed
Nobuyuki Takenaka, Mika Nakao, Kiko Hasegawa, Man Piu Chan, Takaya Satoh
FEBS letters 594 ( 24 ) 4370 - 4380 2020.12
A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes. Reviewed
Nobuyuki Takenaka, Mika Nakao, Sayaka Matsui, Takaya Satoh
International journal of molecular sciences 20 ( 21 ) 2019.10
A critical role for the small GTPase Rac1 in insulin signaling that regulates glucose uptake in skeletal muscle Reviewed
Satoh, T., and Takenaka, N.
Research on Chemical Intermediates An International Journal 2019.07
Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle
Takenaka, N., Araki、N., and Satoh, T.
PLOS ONE 著書 2019.02
Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle. Reviewed
Nobuyuki Takenaka, Natsumi Araki, Takaya Satoh
PloS one 14 ( 2 ) e0212219 2019
ACK1.“Encyclopedia of Signaling Molecules” (2nd Edition, Sangdun Choi, ed; Springer Nature) Reviewed
Takenaka, N., and Satoh, T
Springer Nature 2017.09
In situ detection of the activation of Rac1 and RalA small GTPases in mouse adipocytes by immunofluorescent microscopy following in vivo and ex vivo insulin stimulation. Reviewed
Takenaka, N., Nihata, Y., Ueda, S., and Satoh, T.
Cellular Signaling 39 2017.07
Rac1 activation caused by membrane translocation of a guanine nucleotide exchange factor in Akt2-mediated insulin signaling in mouse skeletal muscle. Reviewed
Takenaka, N., Nihata, Y., and Satoh, T
PLOS ONE 著書 11 ( 5 ) 2016.05
Role for RalA downstream of Rac1 in skeletal muscle insulin signalling.
Takenaka, N., Sumi, T., Matsuda, K., Fujita, J., Hosooka, T., Noguchi, T., Aiba, A., and Satoh, T
Biochemical Journal 著書 469 ( 3 ) 2015.07
Immunofluorescent detection of the activation of the small GTPase Rac1 in mouse skeletal muscle fibers. Reviewed
Takenaka, N., Nihata, Y., and Satoh, T
Analytical Biochemistry 476 2014.09
Phospholipase Cε, an effector of Ras and Rap small GTPases, is required for airway inflammatory response in a mouse model of bronchial asthma. Reviewed
Nagano, T., Edamatsu, H., Kobayashi, K., Takenaka, N., Yamamoto, M., Sasaki, N., Nishimura, Y., and Kataoka, T.
PLOS ONE 雑誌 9 ( 9 ) 2014.09
A critical role of the small GTPase Rac1 in Akt2-mediated GLUT4 translocation in mouse skeletal muscle. Reviewed
Takenaka, N., Izawa, R., Wu, J., Kitagawa, K., Nihata, Y., Hosooka, T., Noguchi, T., Ogawa, W., Aiba, A., and Satoh, T.
FEBS J. 雑誌 Wiley 281 2014.01
Role of the guanine nucleotide exchange factor in Akt2-mediated plasma membrane translocation of GLUT4 in insulin-stimulated skeletal muscle Reviewed
Takenaka, N., Yasuda, N., Nihata, Y., Hosooka, T., Noguchi, T., Aiba, A., and Satoh, T.
Cellular Signalling 雑誌 ELSEVIER 2014
MDCK cell culture-derived formalin-inactivated influenza whole virion vaccine from an influenza virus library conferred cross-protective immunity by intranasal administration in mice Reviewed
Haredy,A., Takenaka,N.,Yamada,H., Sakoda,Y., Okamatsu,M., Yamamoto,N., Omasa,T., Ohtake,H.,Mori,Y.,Kida,H., Yamanishi,K.,Okamoto,S
Clinical and Vaccine Immunology 雑誌 ASM press 20 ( 7 ) 2013.05
Akt2 regulates Rac1 activity in the insulin-dependent signaling pathway leading to GLUT4 translocation to the plasma membrane in skeletal muscle cells. Reviewed
Nozaki, S, Takeda, T, Kitaura, T, Takenaka, N., Kataoka, T. and Satoh
Cellular Signalling 雑誌 ELSEVIER 25 2013.03
Comparison of the cross-reactive anti-influenza neutralizing activity of polymeric and monomeric IgA monoclonal antibodies. Reviewed
Tanimoto, T., Haredy, A., Takenaka, N., Tamura, S., Okuno, Y., Mori, Y., Yamanishi, K., and Okamoto, S.
Viral immune. 雑誌 Mary ann libert 25 ( 5 ) 2012.10
Influenza virus neuraminidase contributes to the dextran sulfate-dependent suppressive replication of some influenza A virus strains. Reviewed
Yamada, H., Haredy, A., Takenaka, N., Mori, Y., Yamanishi, K., and Okamoto, S.
Antiviral research 雑誌 ELSEVIER 96 ( 3 ) 2012.09
Complementation of the function of glycoprotein H of human herpesvirus-6 variant A by glycoprotein H of variant B in the viral life cycle. Reviewed
Oyaizu, H., Tang, H., Ota, M., Takenaka, N., Ozono, K., Yamanishi K., and Moir, Y.
Journal of Virology 雑誌 ASM press 86 ( 16 ) 2012.08
Role of RalA downstream of Rac1 in insulin-dependent glucose uptake in muscle cells. Reviewed
Nozaki, S, Ueda, S., Takenaka, N., Kataoka, T. and Satoh, T
Cellular Signalling 雑誌 ELSEVIER 24 2012.07
Intranasal immunization with formalin-inactivated human influenza A whole-virion vaccine alone or split-virion vaccine with mucosal adjuvants show similar cross-protection. Reviewed
Okamoto, S., Matsuoka, S., Takenaka, N., Haredy, A., Tanimoto, T., Gomi, Y., Ishikawa, T.,Akagi, T., Akashi, M., Okuno, Y., Mori, Y. and Yamanishi, K.
Clinical and Vaccine Immunology 雑誌 ASM press 19 ( 7 ) 2012.05
Phospholipase Ce as a potential molecular target for anti-inflammatory therapy and cancer prevention. Reviewed
Edamatsu, H., Takenaka, N., Hu, L. and Kataoka
Inflammation and regeneration 雑誌 J-Stage 31 2011.11
Phospholipase Cε plays a crucial role in ultraviolet B-induced neutrophil-associated skin inflammation by regulating the expression of CXCL1/KC. Reviewed
Oka, M., Edamatsu, H., Kunisada, M., Hu, L., Takenaka, N., Sakaguchi, M., Kataoka, T., and Nishigori, C.
Laboratory Investigation 雑誌 nature 91 2011.02
Overexpression of phospholipase Ce in keratinocytes upregulates cytokine expression and causes dermatitis with acanthosis and T-cell infiltration. Reviewed
Takenaka, N., Edamatsu, H., Suzuki, N., Saito, H., Inoue, Y., Oka, M., Hu, L., and Kataoka, T.
European journal of imunology 雑誌 Wiley 41 ( 1 ) 2011.01
Enhancement of ultraviolet B-induced skin tumor development in phospholipase Cε-knockout mice is associated with decreased cell death. Reviewed
Oka, M., Edamatsu, H., Kunisada, M., Hu, L., Takenaka, N., Dien, S., Sakaguchi, M., Kitazawa, R., Norose, K., Kataoka, T., and Nishigori, C
Carcinogenesis 雑誌 Oxford journal 31 ( 10 ) 2010.08
Crucial role of phospholipase Ce in induction of local skin inflammatory reactions in the elicitation stage of allergic contact hypersensitivity. Reviewed
Hu, L., Edamatsu, H., Takenaka, N., Ikuta, S., and Kataoka, T.
Eur. J. Immunol. 雑誌 Wiley 184 ( 2 ) 2010.01
バイオサイエンス実験 入門から応用へ
石原 道博, 居原 秀, 恩田 真紀, 川西 優喜, 木下 誉富, 児玉 靖司, 佐藤 孝哉, 白石 一乗, 竹田 恵美, 竹中 延之, 円谷 健, 西野 貴子, 原 正之, 藤井 郁雄, 藤原 大祐, 森 英樹, 八木 孝司, 吉原 静恵（ Role： Joint author）
大阪公立大学共同出版会 2016.03
3T3-L1脂肪細胞での脂肪酸輸送担体CD36を介するインスリン応答性脂肪酸取込みにおける低分子量GTPアーゼRac1の役割の検討 Domestic conference
陳 敏彪、竹中 延之、阿部 佑紀、佐藤 孝哉
第46回日本分子生物学会年会 2023.12
3T3-L1脂肪細胞での脂肪酸輸送担体CD36を介するインスリン応答性脂肪酸取込みにおける低分子量GTPアーゼRalAの関与の検討 Domestic conference
阿部 佑紀、竹中 延之、陳 敏彪、佐藤 孝哉
第46回日本分子生物学会年会 2023.11
レプチン欠損肥満マウスの骨格筋における低分子量GTPアーゼRac1を介するインスリンシグナル伝達系の障害 Domestic conference
陳 敏彪、竹中 延之、佐藤 孝哉
第96回日本生化学会大会 2023.10
Role of the small GTPase Rac1 in insulin-stimulated fatty acid uptake in mouse white adipocytes Domestic conference
2022.12
Role of the GTP-binding protein Rac1 in insulin-stimulated glucose uptake and lipogenesis in mouse brown adipocytes Domestic conference
2022.12
Role of the small GTPase Rac1 in hypertrophy of white adipocytes Domestic conference
2022.12
褐色脂肪細胞でのインスリン応答性糖取り込みにおける低分子量GTPアーゼRac1の機能
田中 るいん, 竹中 延之, 佐藤 孝哉
日本生化学会大会プログラム・講演要旨集 2021.11 (公社)日本生化学会
肥満と2型糖尿病のモデルマウスの骨格筋におけるインスリンシグナル伝達系の解析
陳 敏彪, 竹中 延之, 佐藤 孝哉
日本生化学会大会プログラム・講演要旨集 2021.11 (公社)日本生化学会
白色脂肪細胞でのインスリン応答性脂肪酸取り込みにおける低分子量GTPアーゼRac1の機能
坂田 瑞希, 竹中 延之, 佐藤 孝哉
日本生化学会大会プログラム・講演要旨集 2021.11 (公社)日本生化学会
白色脂肪細胞でのインスリン応答性糖取り込みにおけるRac1によるRalAの制御
長谷川 紀子, 陳 敏彪, 坂田 瑞希, 竹中 延之, 佐藤 孝哉
日本生化学会大会プログラム・講演要旨集 2021.11 (公社)日本生化学会
脂肪細胞でのインスリン応答性糖取り込みにおけるタンパク質キナーゼAkt2による低分子量GTP結合タンパク質Rac1の制御
中尾 美翔, 竹中 延之, 佐藤 孝哉
日本生化学会大会プログラム・講演要旨集 2019.09 (公社)日本生化学会
白色脂肪細胞でのインスリン依存性糖取り込みにおけるRac1の活性制御
長谷川 紀子, 竹中 延之, 佐藤 孝哉
日本生化学会大会プログラム・講演要旨集 2019.09 (公社)日本生化学会
脂肪酸トランスポーターの細胞内動態の分析方法、及び脂肪酸トランスポーター改変タンパク質の利用
竹中延之、佐藤孝哉
Cell biology
2021
Biochemistry I
2021
First Year Seminar
2021
Fundamental Experiments of Biology
2021 Practical Training
Molecular Biology I
2021