Updated on 2024/04/01

写真a

 
ISHIBASHI Osamu
 
Organization
Graduate School of Agriculture Department of Applied Biological Chemistry Associate Professor
School of Agriculture Department of Applied Biological Chemistry
Title
Associate Professor
Affiliation
Institute of Agriculture

Position

  • Graduate School of Agriculture Department of Applied Biological Chemistry 

    Associate Professor  2022.04 - Now

  • School of Agriculture Department of Applied Biological Chemistry 

    Associate Professor  2022.04 - Now

Degree

  • 理学修士 ( Tokyo Institute of Technology )

  • 博士(工学) ( Others )

Research Areas

  • Life Science / Applied molecular and cellular biology  / Molecular biology, Molecular pathology, RNA biology

  • Life Science / General surgery and pediatric surgery

  • Life Science / Orthopedics

Research Interests

  • bone metabolism

  • non-coding RNA

  • biomarker

  • Environmental allergy

  • 甲状腺癌

  • GPCR

  • house-dust-induced allergy

  • Bone Metabolism

  • non-coding RNA

  • osteoclast

  • thyroid carcinoma

  • molecular diagnosis

  • podocyte

  • biomarker

Research subject summary

  • リガンド未同定(オーファン)GPCRによる破骨細胞分化・機能制御

  • 甲状腺濾胞癌の分子診断を可能にするバイオマーカーの探索

  • 腎糸球体ポドサイト障害応答性トランスクリプトの探索と腎疾患バイオマーカーへの応用

  • 屋内環境に生息する微小昆虫チャタテムシの新規アレルゲンコンポーネントの同定と活性評価

Research Career

  • Functional analysis of an orphan GPCR that is selectively expressed in osteoclasts

    Orphan GPCR, Osteoclast, Genome editing  Joint Research in Japan

    2013.04 - Now 

  • 甲状腺濾胞癌の分子診断を可能にするバイオマーカーの探索

    甲状腺濾胞癌、分子診断、バイオマーカー  Joint Research in Japan

    2012.04 - Now 

  • 腎糸球体ポドサイト障害応答性トランスクリプトの探索と腎疾患バイオマーカーへの応用

    ポドサイト、糸球体障害  Joint Research in Japan

    2013.04 - Now 

  • 屋内環境アレルゲンである微小昆虫チャタテムシの新規アレルゲンコンポーネントの同定とアレルギー診断法の開発

    ヒラタチャタテ、チャタテムシ、アレルギー、アレルゲンコンポーネント  Joint Research in Japan

    2015.04 - Now 

Professional Memberships

  • 日本分子生物学会

    2014.10 - Now

  • 日本生化学会

    2012 - Now   Domestic

  • 日本生殖免疫学会

    2008 - Now   Domestic

  • 日本RNA学会

    2007 - Now   Domestic

  • 日本骨代謝学会

    1998 - Now   Domestic

Committee Memberships (off-campus)

  • 評議員   日本生殖免疫学会  

Awards

  • Kansai TechPlan 2023

    Team Allosergon (Head: Osamu Ishibashi)

    2023.11  

  • 第23回日本生殖免疫学会優秀賞

    2008.12   日本生殖免疫学会  

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    Country:Japan

  • 第16回日本胎盤学会相馬賞

    2008.10   日本胎盤学会  

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    Country:Japan

  • The 2nd Joint Meeting of The American Society for Bone and Mineral Research and the International Bone and Mineral Society: Travel Award

    1998.12   The American Society for Bone and Mineral Research and the International Bone and Mineral Society  

  • 第14回日本骨代謝学会優秀演題

    1996.07   日本骨代謝学会  

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    Country:Japan

Papers

  • Usefulness of ultrasonographic detective flow imaging to evaluate parathyroid adenoma in patients with primary hyperparathyroidism Reviewed

    Akasu, Haruki, Jikuzono, Tomoo, Matsui, Mami, Sen, Masaomi, Saitou, Marie, Ishibashi, Osamu, Sugitani, Iwao

    Journal of Nippon Medical School   ( In Press )   2024.01

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    Publishing type:Research paper (scientific journal)  

  • Review: Regulation of macrophage polarization in allergy by noncoding RNAs

    Non-coding RNA   InPress   2023.12

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)  

    DOI: 10.51094/jxiv.499

  • Identification of a novel carboxylesterase dominantly expressed in the booklouse, Liposcelis bostrychophila

    Osamu Ishibashi

    Journal of Stored Products Research   104   2023.12( ISSN:0022-474X

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    Authorship:Lead author, Last author, Corresponding author   Publishing type:Research paper (scientific journal)  

    Booklice are tiny insect pests commonly found indoors and characterized by high proliferation ability. Booklice contamination in stored foods causes profound food loss and possibly allergic reactions after ingestion; thus, booklice are known as stored-food pests. Therefore, the safe extermination of booklice would solve food loss and allergic concerns. Organophosphates (OPs) are used as harmless insecticides against various pests; nonetheless, cases of OP poisoning are reported worldwide. Therefore, considering protecting stored-food products, OP doses should be minimal. It is generally known that carboxylesterase-mediated inactivation of OPs decreases the efficacy of OPs, suggesting that an inhibitor of carboxylesterase could be a synergist in reducing the effective dose of OP. Herein, I report the molecular cloning of a novel carboxylesterase dominantly expressed in a representative species of indoor booklice, Liposcelis bostrychophila, designated Liposcelis bostrychophila carboxylesterase 1 (LBCE1). The recombinant protein of LBCE1 was shown to have an elastase activity. Furthermore, using the 3D-structural model of LBCE1, its possible binding to OP insecticides was predicted in silico. These results suggest that a specific LBCE1 inhibitor may serve as a synergist to better control booklice.

    DOI: 10.1016/j.jspr.2023.102179

  • Usefulness of ultrasonographic detective flow imaging to diagnose parathyroid tumors: two case reports.

    Mami Matsui, Tomoo Jikuzono, Shoko Kure, Osamu Ishibashi, Haruki Akasu, Iwao Sugitani

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   2022.10

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    Parathyroid tumors (PTs) are sometimes difficult to diagnose because they are small and have a low-velocity blood flow, which can be missed by current imaging modalities. PTs consist of parathyroid adenoma (PA), parathyroid cyst, and parathyroid carcinoma (PC). Detective flow imaging (DFI) is a new imaging technology that displays a low-velocity blood flow. Herein, we report two cases in which DFI was useful for the diagnosis of PTs. One case consisted of a PA and a parathyroid cyst in close proximity, and the other was a PC. To the best of our knowledge, this is the first report to demonstrate the usefulness of DFI in the diagnosis of PTs.

    DOI: 10.1272/jnms.JNMS.2023_90-604

    PubMed

  • Associations of AminoIndex Cancer Screening (Breast) Grade with Clinical and Laboratory Variables.

    Tomoo Jikuzono, Osamu Ishibashi, Shoko Kure, Yumi Ohmae, Toshimichi Ohmae

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   89 ( 4 )   377 - 383   2022.08

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    BACKGROUND: Altered metabolism in the blood of cancer patients is closely related to changes in amino acids. Amino acids play an important physiological role as essential metabolites and regulators of metabolism. AminoIndex Cancer Screening (AICS) uses multivariate analysis of plasma-free amino acid profiles to screen for seven cancer types, including breast cancer. METHODS: To determine the clinical utility of AICS (breast), we retrospectively analyzed associations of AICS (breast) score with clinical and laboratory variables in 390 patients who underwent AICS (breast) testing. The mean age of participants was 50.7 years (range: 26-87 years) and all were female. RESULTS: The AICS (breast) grade was A, B, and C for 250 (64.1%), 90 (23.1%), and 50 (12.8%) participants, respectively. AICS (breast) was significantly correlated with AICS (gastric) (r = 0.487, p < 0.0001) and AICS (lung) (r = 0.523, p < 0.0001). Multivariate linear regression analysis showed no significant difference of AICS (breast) grade with age, body mass index, estimated glomerular filtration rate, dyslipidemia, or blood pressure. However, neutrophil-to-lymphocyte ratio significantly differed in relation to AICS (breast) grade (cut-off value, 1.7; p = 0.030), although only data from 72 patients were analyzed. CONCLUSION: To our knowledge, this is the first study to report associations of AICS (breast) grade with clinical variables.

    DOI: 10.1272/jnms.JNMS.2022_89-403

    PubMed

  • The Role of miR-217-5p in the Puromycin Aminonucleoside-Induced Morphological Change of Podocytes. Invited Reviewed

    Osamu Ishibashi, Mika Hayashi, Aya Horikawa, Hitoshi Owada, Ryotaro Miyamoto, Naoya Mizukami, Takashi Inui

    Non-coding RNA   8 ( 3 )   2022.06

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Podocytes, alternatively called glomerular epithelial cells, are terminally differentiated cells that wrap around glomerular capillaries and function as a part of the glomerular filtration barrier in the kidney. Therefore, podocyte injury with morphological alteration and detachment from glomerular capillaries leads to severe proteinuria and subsequent renal failure through glomerulosclerosis. Previous RNA sequencing analysis of primary rat podocytes exposed to puromycin aminonucleoside (PAN), a well-known experimental model of injured podocytes, identified several transcripts as being aberrantly expressed. However, how the expression of these transcripts is regulated remains unclear. MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally inhibit the expression of their target transcripts. In this study, using small RNA sequencing analysis, miR-217-5p was identified as the most upregulated transcript in PAN-treated rat podocytes. MiR-217-5p overexpression in E11 podocyte cells led to shrunken cells with abnormal actin cytoskeletons. Consistent with these changes in cell morphology, gene ontology (GO) enrichment analysis showed that interactive GO terms related to cell morphogenesis were enriched with the predicted targets of miR-217-5p. Of the predicted targets highly downregulated by PAN, Myosin 1d (Myo1d) is a nonmuscle myosin predicted to be involved in actin filament organization and thought to play a role in podocyte morphogenesis and injury. We demonstrated that miR-217-5p targets Myo1d by luciferase assays, qRT-PCR, and Western blotting. Furthermore, we showed that miR-217-5p was present in urine from PAN- but not saline-administrated rats. Taken together, our data suggest that miR-217-5p may serve as a therapeutic target and a biomarker for podocyte injury.

    DOI: 10.3390/ncrna8030043

    PubMed

  • Use of ultrasonographic shear wave measurements to diagnose thyroid metastasis from breast carcinoma.

    Masae Hoshi, Tomoo Jikuzono, Shigekazu Suzuki, Osamu Ishibashi, Yoko Kawamoto, Shoko Kure, Masashi Kawamoto, Ryuji Ohashi, Iwao Sugitani

    Journal of Nippon Medical School = Nippon Ika Daigaku zasshi   2022.05

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:Domestic journal  

    A metastatic thyroid tumor (MTT) arising from breast carcinoma (BC) is rare and sometimes difficult to diagnose. We present a case of MTT from BC; we suspected anaplastic thyroid carcinoma at initial presentation. The patient was a 58-year-old female with a hard nodule in the right anterior neck and a history of breast cancer. Computed tomography indicated tumors on both thyroid lobes, and ultrasonography (US) with shear wave measurement (SWM) showed malignant features. We performed fine needle aspiration cytology (FNAC), the results of which led us to strongly suspect MTT from BC. The surgically resected specimen was evaluated histopathologically, including by immunohistochemistry (IHC), and the diagnosis was confirmed. In addition to FNAC and IHC, SWM is useful to diagnose MTT from BC.

    DOI: 10.1272/jnms.JNMS.2023_90-501

    PubMed

  • RNA recovery from specimens of duct-washing cytology performed contemporaneously with mammary ductoscopy. Reviewed

    Tomoo Jikuzono, Eriko Manabe, Shoko Kure, Haruki Akasu, Tomoko Ishikawa, Yoko Fujiwara, Masujiro Makita, Osamu Ishibashi

    BMC research notes   15 ( 1 )   34 - 34   2022.02

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    Authorship:Corresponding author   Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    OBJECTIVE: Conventional cytological diagnosis including duct-washing cytology (DWC) is sometimes performed using ductal epithelial cells collected during mammary ductoscopy; it is useful for detection of early-stage breast cancer such as ductal carcinoma in situ (DCIS). However, conventional cytological diagnosis focuses exclusively on cellular morphology; false negatives and false positives may be caused by inadequate specimen preparation (triggering cell degeneration) or poor examiner diagnostic skills. Molecular diagnosis using RNA biomarkers is expected to compensate for the weaknesses of cytological diagnosis. We previously employed microarray analysis to identify highly expressed genes in DCIS, suggesting that they may be useful for DCIS diagnosis. Here, we explored whether DWC samples yielded RNA of sufficient quantity and quality for RNA biomarker-based diagnosis. RESULTS: We extracted RNAs from 37 DWC samples. RNA from 12 samples exhibited RNA integrities of  ≥ 6, indicative of moderate-to-high quality. We then showed that cocaine and amphetamine regulated transcript prepropeptide (CARTPT) and breast cancer-associated transcript 54 (BRCAT54) mRNA-previously shown by microarray analysis to be highly expressed in DCIS-were detectable in these samples. Therefore, DWC samples may be useful for molecular diagnosis involving RNA biomarkers.

    DOI: 10.1186/s13104-022-05928-1

    PubMed

  • VsN, a Reliability-index of Shear-wave Measurement in Sonoelastography, Is Useful for the Diagnosis of Thyroid Tumor Malignancy Reviewed

    Jikuzono T, Ishibashi O, Kure S, Itoh C, Yamada T, Sugitani I.

    In Vivo 雑誌   36 ( 1 )   264 - 273   2022.01

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    Kind of work:Joint Work  

  • Structure-based prediction of the IgE epitopes of the major dog allergen Can f 1. Reviewed

    Nakatsuji M, Sugiura K, Suda K, Sakurai M, Ubatani M, Muroya H, Okubo R, Noguchi R, Kamata Y, Fukutomi Y, Ishibashi O, Nishimura S, Inui T.

    FEBS J. 雑誌   2021.10

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  • Microarray analysis of ductal carcinoma in situ samples obtained by puncture from surgical resection specimens Reviewed

    Tomoo Jikuzono, Eriko Manabe, Shoko Kure, Haruki Akasu, Tomoko Ishikawa, Yoko Fujiwara, Masujiro Makita, Osamu Ishibashi

    BMC Research Notes 雑誌 BMC   14 ( 1 )   2021.08

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  • Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report Reviewed

    Tomoo Jikuzono, Shigekazu Suzuki, Osamu Ishibashi, Shoko Kure, Atsuko Sakanushi, Munenaga Nakamizo, Masashi Kawamoto, Ryuji Ohashi, Tetsu Yamada, Iwao Sugitani

    Journal of Nippon Medical School 雑誌   2021

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  • Microarray analysis of formalin-fixed, paraffin-embedded follicular thyroid carcinoma samples from patients who developed postoperative distant metastasis. Reviewed

    Jikuzono T, Ishikawa T, Hirokawa M, Sugitani I, Ishibashi O.

    BMC Res. Notes, 13, 241, 2020.   13 ( 241 )   2020.05

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  • Crystal structure of the dog allergen Can f 6 and structure-based implications of its cross-reactivity with the cat allergen Fel d 4. Reviewed

    Yamamoto K†, Ishibashi O†, Sugiura K, Ubatani M, Sakaguchi M, Nakatsuji M, Shimamoto S, Noda M, Uchiyama S, Fukutomi Y, Nishimura S, Inui T

    Sci. Rep. 雑誌   9   2019

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  • Gpr137b is an orphan G-protein-coupled receptor associated with M2 macrophage polarization. Reviewed

    Islam Z, Inui T, Ishibashi O

    Biochem. Biophys.Res. Commun. 雑誌   509   657 - 663   2019

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  • Datasets of microarray analysis to identify Gpr137b-dependent interleukin-4-responsive genes in the mouse macrophage cell line RAW264. Reviewed

    Islam Z, Inui T, Ishibashi O

    Data Brief 雑誌   2019

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    Kind of work:Joint Work  

  • A novel splicing variant of small nucleolar RNA host gene 4 is a podocyte-selective non-coding RNA upregulated in response to puromycin aminonucleoside-induced podocyte injury. Reviewed

    Horikawa A, Yoneda T, Yaoita E, Yamaguchi K, Shigenobu S, Kuramochi M, Yamate J, Inui T, Ishibashi O

    J. Biochem. 雑誌   165 ( 5 )   447 - 454   2019

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  • Proteinase K treatment improves RNA recovery from thyroid cells fixed with liquid-based cytology solution. Reviewed

    Jikuzono T, Horikawa A, Ishikawa T, Hirokawa M, Sugitani I, Inui T, Ishibashi O

    BMC Res. Notes 雑誌   2018

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  • MiR-141-3p is upregulated in esophageal squamous cell carcinoma and targets pleckstrin homology domain leucine-rich repeat protein phosphatase-2, a negative regulator of the PI3K/AKT pathway. Reviewed

    Ishibashi O, Akagi I, Ogawa Y, Inui T

    Biochem. Biophys.Res. Commun. 雑誌   501   507 - 513   2018

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  • Lip b 1 is a novel allergenic protein isolated from the booklouse, Liposcelis bostrychophila.

    Ishibashi O, Sakuragi K, Fukutomi Y., Kawakami Y, Kamata Y, Sakurai M, Nakayama S, Uchiyama H, Kobayashi H, Kojima H, Inui T

    Allergy   72   918 - 926   2017

  • RNA-Seq analysis of human cell lines established from normal and neoplastic esophageal squamous epithelium. Reviewed

    Akagi I, Ishibashi O

    Genom. Data 雑誌   5   4 - 6   2017

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  • Development of pH-Independent Drug Release Formulation Using Lipocalin-Type Prostaglandin D Synthase Reviewed

    Mizoguchi M, Nakatsuji M, Takano J, Ishibashi O, Wada K, Inui T

    J. Pharm. Sci. 雑誌   105   2735 - 2742   2016

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  • Novel Characteristics of Trypanosoma brucei Guanosine 5'-monophosphate Reductase Distinct from Host Animals. Reviewed

    Bessho T, Okada T, Kimura C, Shinohara T, Tomiyama A, Imamura A, Kuwamura M, Nishimura K, Fujimori K, Shuto S, Ishibashi O, Kubata BK, Inui T

    PLoS Negl. Trop. Dis 雑誌   10   2016

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  • miR-200a, miR-200b and miR-429 Are Onco-miRs that Target the PTEN Gene in Endometrioid Endometrial Carcinoma. Reviewed

    Yoneyama, K., Ishibashi, O., Kawase, R., Kurose, K., Takeshita, T.

    Anticancer Res. 雑誌   35 ( 3 )   1401 - 1410   2015.03

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    Kind of work:Joint Work  

  • Novel Characteristics of Trypanosoma brucei Guanosine 5’-monophosphate Reductase Distinct from Host Animals.

    Bessho, T., Okada, T., Kimura, C., Shinohara, T., Tomiyama, A., Imamura, A., Kuwamura, M., Nishimura, K., Fujimori, K., Shuto, S., Ishibashi, O., Kubata, K., Inui, T.

    PLOS Negl. Trop. Dis.   2015

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  • Human Lipocalin-type Prostaglandin D Synthase-Based Drug Delivery System for Poorly Water-Soluble Anti-Cancer Drug SN-38. Reviewed

    Nakatsuji, M., Inoue, H., Kohno, M., Saito, M., Tsuge, S., Shimizu, S., Ishida, A., Ishibashi, O., Inui, T.

    PLOS ONE 雑誌   10 ( e0142206 )   2015

  • Dataset of microarray analysis to identify endoglin-dependent bone morphogenetic protein-2-responsive genes in the murine periodontal ligament cell line PDL-L2. Reviewed

    Ishibashi, O., Inui, T.

    Genomics Data 雑誌   2   24 - 26   2014

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  • Interactions between the non-seed region of siRNA and RNA-binding RLC/RISCproteins, Ago and TRBP, in mammalian cells. Reviewed

    Takahashi, T., Zenno, S., Ishibashi, O., Takizawa, T., Saigo, K., Ui-Tei, K.

    Nucleic Acids Research 雑誌   42   2014

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  • Comprehensive Analysis of MicroRNA and mRNA Expression in Normal and Tumorous Human Esophageal Squamous Cell Lines Using Microarray Datasets. Reviewed

    Akagi, I., Ishibashi, O., Matsutani, T., Hagiwara, N., Matsuda, A., Nomura, T., Makino, H., Yoshida, H., Miyashita, M., Uchida, E.

    Dataset Papers Sci. 雑誌   376541   2014

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  • Bone Morphogenetic Protein-2 Desensitizes MC3T3-E1 Osteoblastic Cells to Estrogen Through Transcriptional Downregulation of Estrogen Receptor 1. Reviewed

    Ishibashi, O.

    Journal of Bone Metabolism 雑誌   20   2013

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    Kind of work:Single Work  

  • Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by mir-210 and mir-518c that are aberrantly expressed in preeclamptic placentas: A novel marker for predicting preeclampsia. Reviewed

    Ishibashi, O.#, Ohkuchi, A.#, Ali, M.M., Kurashina, R., Luo, S-S., Ishikawa, T., Takizawa, T., Hirashima, C, Takahashi, K., Migita, M., 他7名(#共同筆頭著者)

    Hypertension. 雑誌   2012.02

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  • Plasma level of hydroxysteroid (17-beta) dehydrogenase 1 in the second trimester is an independent risk factor for predictiong preeclampsia after adjusting for the effects of mean blood pressure, bilateral notching and plasma level of soluble fms-like tyrosine kinase 1/placental growth factor ratio. Reviewed

    Ohkuchi, A.†, Ishibashi, O.†, Hirachima, C., Takahashi, K., Matsubara, S., Takizawa, T., *Suzuki, M. (†共筆頭著者)

    Hypertension Research 雑誌   35   2012

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  • MiR-21 is enriched in the RNA-induced silencing complex and targets COL4A1 in human granulosa cell lines. Reviewed

    Mase, Y., Ishibashi, O., Ishikawa, T., Takizawa, T., Kiguchi, T., Ohba, T., Katabuchi, H., Takeshita, T., Takizawa, T.

    Reproductive Sciences 雑誌   19   2012

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  • Short RNA duplexes elicit RIG-I-mediated apoptosis in a cell type- and length-dependent manner. Reviewed

    Ishibashi, O., Ali, M.M., Luo, S-S., Ohba, T., Katabuchi, H., Takeshita, T., Takizawa, T.

    Science Signaling 雑誌   4   2011.11

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  • Relationship between altered expression levels of miR21, miR143, miR145, and miR205 and clinicopathologic features of esophageal squamous cell carcinoma. Reviewed

    Akagi, I., Miyashita, M., Ishibashi, O., Mishima, T., Kikuchi, K., Makino, H., Nomura, T., Hagiwara, N., Uchida, E., Takizawa, T.

    Disease of the Esophagus 雑誌   24   523 - 530   2011.09

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  • Real-time PCR-based microRNAome of human bile detects miR-9 as a potential diagnostic biomarker for biliary tract cancer. Reviewed

    Shigehara, K., Yokomuro, S., Ishibashi, O., Mizuguchi, Y., Arima, Y., Kawahigashi, Y., Kanda, T., Akagi, I., Tajiri, T., Takizawa, T., 他2名

    PLoS ONE 雑誌   6   2011.08

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  • Identification of obstructive jaundice- related microRNAs in mouse Liver. Reviewed

    Kanda, T., Ishibashi, O., Kawahigashi, Y., Mishima, T., Kosuge, T., Mizuguchi, Y., Shimizu, T., Arima, Y., Yokomuro, S., Yoshida, H., 他3名

    Hepato-Gastroenterology 雑誌   57   1013 - 1023   2010.09

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  • Endoglin is involved in BMP-2-induced osteogenic differentiation of periodontal ligament cells through a pathway independent of Smad-1/5/8 phosphorylation. Reviewed

    Ishibashi, O.*, Ikegame, M., Takizawa, F., Yoshizawa, T., Matsuda, A., Ali, M.M., Iizawa, F., Mera, H., Kawashima, H.*(*共同責任著者)

    Journal of Cellular Physiology 雑誌   222   465 - 473   2010.02

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  • Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes. Reviewed

    Luo, S.S.#, Ishibashi, O.#, Ishikawa, G.#, Ishikawa, T., Katayama, A., Mishima, T., Takizawa, T., Shigihara, T., Goto, T., Izumi, A., 他3名 (#共筆頭著者)

    Biology of Reproduction 雑誌   81   717 - 729   2009.10

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  • MicroRNA profiling of human intrahepatic cholangiocarcinoma cell lines reveals biliary epithelial cell-specific microRNAs. Reviewed

    Kawahigashi, Y., Mishima, T., Mizuguchi, Y., Arima, Y., Yokomuro, S., Kanda, T., Ishibashi, O., Yoshida, H., Tajiri, T., Takizawa, T.*

    Journal of Nippon Medical School 雑誌   76   188 - 197   2009.08

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  • Chondromodulin-1 directly suppresses growth of human cancer cells. Reviewed

    Mera, H., Kawashima, H., Yoshizawa, T., Ishibashi, O., Ali, M.M., Hayami, T., Kitahara, H., Yamagiwa, H., Kondo, N., Ogose, A., 他2名

    BMC Cancer 雑誌   9   2009.03

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  • Overexpression of PIK3CA is associated with lymph node metastasis in esophageal squamous cell carcinoma. Reviewed

    Akagi, I., Miyashita, M., Makino, H., Nomura, T., Hagiwara, N., Takahashi, K., Cho, K., Mishima, T., Ishibashi, O., Ushijima, T., 他2名

    International Journal Oncology 雑誌   34   767 - 775   2009.03

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  • MicroRNA (miRNA) cloning analysis reveals sex differences in miRNA expression profiles between adult mouse testis and ovary. Reviewed

    Mishima, T., Takizawa, T., Luo, S.S., Ishibashi, O., Kawahigashi, Y., Mizuguchi, Y., Ishikawa, T., Mori, M., Kanda, T., Goto, T., 他1名

    Reproduction 雑誌   136   811 - 822   2008.12

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  • PIASxbeta is a key regulator of osterix transcriptional activity and matrix mineralization in osteoblasts. Reviewed

    Ali, M.M., Yoshizawa, T., Ishibashi, O., Matsuda, A., Ikegame, M., Shimomura, J., Mera, H., Nakashima, K., Kawashima, H.

    Journal of Cell Science 雑誌   120   2565 - 2573   2007.08

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    Kind of work:Joint Work  

  • MMP-9 antisense oligodeoxynucleotide inhibits osteoclastic bone resorption. Reviewed

    Ishibashi, O.#, Niwa, S.#, Kadoyama, K., Inui, T. (#共同筆頭著者)

    Life Sciences 雑誌   79   1657 - 1660   2006.09

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    Kind of work:Joint Work  

  • Recruitment of osteoclasts in the mandible of osteopetrotic (op/op) mice. Reviewed

    Ida-Yonemochi, H., Ishibashi, O., Sakai, H., Saku, T.

    European Journal of Oral Sciences. 雑誌   112   148 - 155   2004.04

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    Kind of work:Joint Work  

  • Homeobox protein MSX2 acts as a molecular defense mechanism for preventing ossification in ligament fibroblasts. Reviewed

    Yoshizawa, T., Takizawa, F., Iizawa, F., Ishibashi, O., Kawashima, H., Matsuda, A., Endoh, N., Kawashima, H.

    Molecular and Cellular Biology 雑誌   24   3460 - 3472   2004.04

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    Kind of work:Joint Work  

  • Tensile stress induces alpha adaptin C production in mouse calvariae in an organ culture: possible involvement of endocytosis in mechanical stress-stimulated osteoblast differentiation. Reviewed

    Shimomura, J., Ishibashi, O., Ikegame, M., Yoshizawa, T., Ejiri, S., Noda, T., Kawashima, H.

    Journal of Cellular Physiology 雑誌   195   488 - 496   2003.06

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    Kind of work:Joint Work  

  • A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. Reviewed

    Saito, Y., Yoshizawa, T., Takizawa, F., Ikegame, M., Ishibashi, O., Okuda, K., Hara K, Ishibashi, K., Obinata, M., Kawashima, H.

    Journal of Cell Science 雑誌   115   4191 - 4200   2002.11

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    Kind of work:Joint Work  

  • Tamoxifen agonism and estrogen antagonism of c-fos gene promoter activity through non-consensus-responsive elements in MC3T3-E1 osteoblasts. Reviewed

    Ishibashi, O.#, Yamagishi, T.#, Hanada, K., Kawashima, H. (#共同筆頭著者)

    Biochemical and Biophysical Research Communications 雑誌   289   705 - 711   2001.12

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    Kind of work:Joint Work  

  • Brefeldin A inhibits osteoclastic bone resorption through induction of apoptosis. Reviewed

    Niwa, S.#, Ishibashi, O.#, Inui, T. (#共同筆頭著者)

    Life Sciences 雑誌   70   315 - 324   2001.09

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    Kind of work:Joint Work  

  • Cloning and characterization of the functional promoter of mouse estrogen receptor beta gene. Reviewed

    Ishibashi, O., Kawashima, H.

    Biochimica et Biophysica Acta 雑誌   1519   223 - 229   2001.06

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    Kind of work:Joint Work  

  • Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR. Reviewed

    Ishibashi, O., Inui, T., Mori, Y., Kurokawa, T., Kokubo, T., Kumegawa, M.

    Calcified Tissue International 雑誌   68   109 - 116   2001.02

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    Kind of work:Joint Work  

  • Tensile stress induces bone morphogenetic protein 4 in preosteoblastic and fibroblastic cells, which later differentiate into osteoblasts leading to osteogenesis in the mouse calvariae in organ culture. Reviewed

    Ikegame, M., Ishibashi, O., Yoshizawa, T., Shimomura, J., Komori, T., Ozawa, H., Kawashima, H.

    Journal of Bone and Mineral Research 雑誌   16   24 - 32   2001.01

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    Kind of work:Joint Work  

  • Breast cancer cells express cathepsins B and L but not cathepsins K or H. Reviewed

    Ishibashi, O., Mori, Y., Kurokawa, T., Kumegawa, M.

    Cancer Biochemistry and Biophysics 雑誌   17   69 - 78   1999.07

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    Kind of work:Joint Work  

  • Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action. Reviewed

    Inui, T., Ishibashi, O., Origane, Y., Fujimori, K., Kokubo, T., Nakajima, M.

    Biochemical and Biophysical Research Communications 雑誌   289   705 - 711   1999.04

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    Kind of work:Joint Work  

  • Increased expression of lysosomal cysteine proteases with differentiation of HL-60 and THP-1 towards macrophage-like cells induced by phorbol ester. Reviewed

    Ishibashi, O.

    Journal of Biochemistry, Molecular Biology and Biophysics 雑誌   2   259 - 264   1999.01

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    Kind of work:Joint Work  

  • Production and characterization of two variants of human cystatin SA encoded by two alleles at the CST2 locus of the type 2 cystatin gene family. Reviewed

    Saitoh, E., Minaguchi, K., Ishibashi, O.

    Archives of Biochemistry and Biophysics. 雑誌   352   199 - 206   1998.04

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    Kind of work:Joint Work  

  • A new method to synthesize competitor RNAs for accurate analyses by competitive RT-PCR. Reviewed

    Ishibashi, O.

    Journal of Biochemical and. Biophysical Methods. 雑誌   35   203 - 207   1997.12

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    Kind of work:Joint Work  

  • Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption. Reviewed

    Inui, T., Ishibashi, O., Inaoka, T., Origane, Y., Kumegawa, M., Kokubo, T., Yamamura, T.

    Journal of Biological Chemistry 雑誌   272   8109 - 8112   1997.03

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    Kind of work:Joint Work  

  • Localization of cathepsin K in human osteoclasts by in situ hybridization and immunohistochemistry. Reviewed

    Littlewood-Evans, A., Kokubo, T., Ishibashi, O., Inaoka, T., Wlodarski, B., Gallagher, J., Bilbe, G.

    Bone 雑誌   20   81 - 86   1997.02

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    Kind of work:Joint Work  

  • A fruiting body-specific novel cDNA, mfbBc,containing continuous 5′-CCA(A/C)CA direct repeats within the coding region,derived from the basidiomycete Lentinus edodes. Reviewed

    Ishibashi, O., Yamazaki, T., Shishido, K.

    Mycoscience 雑誌   37   227 - 232   1996.07

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    Kind of work:Joint Work  

  • Basidiomycetous ras cDNA functionally replaces its homolog genes in yeast. Reviewed

    Ishibashi, O., Shishido, K.

    Current Genetics 雑誌   25   30 - 33   1996.01

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    Kind of work:Joint Work  

  • Molecular cloning of human cDNA for cathepsin K: novel cysteine proteinase predominantly expressed in bone. Reviewed

    Inaoka T., Bilbe G., Ishibashi, O., Tezuka K, Kumegawa M, Kokubo T.

    Biochemical and Biophysical Research Communications 雑誌   206   89 - 96   1995.01

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    Kind of work:Joint Work  

  • Nucleotide sequence of a ras gene from the basidiomycete Coprinus cinereus. Reviewed

    Ishibashi, O., Shishido, K.

    Gene 雑誌   125   233 - 234   1993.03

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    Kind of work:Joint Work  

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Books and Other Publications

  • 「カテプシンK」:骨粗鬆症ナビゲーター-骨の構造とカルシウム代謝調節機構

    石橋 宰( Role: Joint author)

    メディカルレビュー社(東京)  2001 

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    Responsible for pages:212-216  

  • 「カテプシンK」:最新骨粗鬆症

    石橋 宰,久米川正好

    ライフサイエンス出版(東京)  1999 

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    Responsible for pages:225-235  

  • Role of proteases in osteoclastic resorption: In Advances in Organ Biology

    Kokubo T, Ishibashi O, Kumegawa M( Role: Joint author)

    JAI Press Inc. (Greenwich, CT)  1999 

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    Responsible for pages:359-370  

Presentations

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Industrial Property Rights

  • Follicular thyroid-specific biomarker

    Osamu Ishibashi, Tomoo Jikuzono

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    property_type:Patent 

    Application no:PCT/JP20222/015687 

    Announcement no:特開WO2022/210783 

  • Follicular thyroid-specific biomarker

    Osamu Ishibashi, Tomoo Jikuzono

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    property_type:Patent 

    Application no:特願2021- 57814; PCT/JP20222/015687 

    Announcement no:特開WO2022/210783 

Collaborative research (seeds) keywords

  • 甲状腺癌診断ツール開発

    Category:Life Science 

  • 環境アレルゲン検査

    Category:Life Science 

Outline of collaborative research (seeds)

  • 屋内環境中の微小昆虫チャタテムシによるアレルギーの診断と治療戦略

  • 腎糸球体ポドサイト障害応答性トランスクリプトの探索と腎疾患バイオマーカーへの応用

  • 破骨細胞選択的に高発現するオーファンGPCRの機能解析

  • 甲状腺濾胞癌の分子診断を可能にするバイオマーカーの探索

Grant-in-Aid for Scientific Research

  • リバビリンによる抗原虫作用の機序解明に基づくアフリカトリパノソーマ症の新薬開発

    2023

  • 細胞診および血液検体を用いた新規甲状腺濾胞癌特異的マーカーによる術前分子診断

    2023

  • リガンド非依存的GPCR活性化による破骨細胞の分化・機能制御の機構解明

    2023

  • 関節内の細胞外小胞体による局所恒常性維持の機序解明

    2023

  • 甲状腺微小乳頭癌の個別的管理のためのバイオマーカー探索と患者報告アウトカム研究

    2022

  • 関節内の細胞外小胞体による局所恒常性維持の機序解明

    2022

  • リガンド非依存的GPCR活性化による破骨細胞の分化・機能制御の機構解明

    2022

  • リバビリンによる抗原虫作用の機序解明に基づくアフリカトリパノソーマ症の新薬開発

    Grant-in-Aid for Challenging Research (Pioneering)/(Exploratory)  2022

  • 甲状腺細胞診検体を用いた濾胞癌におけるゲノムワイド分子診断マーカーの探索

    2021

  • 甲状腺微小乳頭癌の個別的管理のためのバイオマーカー探索と患者報告アウトカム研究

    2021

  • 関節内の細胞外小胞体による局所恒常性維持の機序解明

    2021

  • 重症喘息の気道に腐生する真菌へのアレルギー診断法の開発とその実態解明

    2021

  • リガンド非依存的GPCR活性化による破骨細胞の分化・機能制御の機構解明

    2021

  • 甲状腺細胞診検体を用いた濾胞癌におけるゲノムワイド分子診断マーカーの探索

    2020

  • リガンド非依存的GPCR活性化による破骨細胞の分化・機能制御の機構解明

    2020

  • 関節軟骨修復に寄与するマイクロRNAの探索

    2020

  • 重症喘息の気道に腐生する真菌へのアレルギー診断法の開発とその実態解明

    2020

  • 甲状腺微小乳頭癌の個別的管理のためのバイオマーカー探索と患者報告アウトカム研究

    2020

  • 低アレルゲン化ワクチンを用いたアレルゲン免疫療法によるイヌアレルギー治療への挑戦

    2019

  • 関節軟骨修復に寄与するマイクロRNAの探索

    2019

  • 甲状腺細胞診検体を用いた濾胞癌におけるゲノムワイド分子診断マーカーの探索

    2019

  • リガンド非依存的GPCR活性化による破骨細胞の分化・機能制御の機構解明

    2019

  • 低アレルゲン化ワクチンを用いたアレルゲン免疫療法によるイヌアレルギー治療への挑戦

    2018

  • 破骨細胞特異的Gタンパク質共役受容体GPR137Bの機能解析と制御化合物探索

    2018

  • 関節軟骨修復に寄与するマイクロRNAの探索

    2018

  • 低アレルゲン化ワクチンを用いたアレルゲン免疫療法によるイヌアレルギー治療への挑戦

    2017

  • 破骨細胞特異的Gタンパク質共役受容体GPR137Bの機能解析と制御化合物探索

    2017

  • 破骨細胞特異的Gタンパク質共役受容体GPR137Bの機能解析と制御化合物探索

    2016

  • GMP reductaseを標的とした新規アフリカ睡眠病治療薬の開発

    2015

  • 癌指向性を有する難水溶性薬剤内包タンパク質ナノカプセルの開発とDDSへの応用

    2015

  • GMP reductaseを標的とした新規アフリカ睡眠病治療薬の開発

    2014

  • 癌指向性を有する難水溶性薬剤内包タンパク質ナノカプセルの開発とDDSへの応用

    2014

  • GMP reductaseを標的とした新規アフリカ睡眠病治療薬の開発

    2013

  • 癌指向性を有する難水溶性薬剤内包タンパク質ナノカプセルの開発とDDSへの応用

    2013

  • 妊娠高血圧症候群に伴う蛋白尿発症に関わるマイクロRNAの同定と機能解析

    2013

  • 妊娠高血圧症候群に伴う蛋白尿発症に関わるマイクロRNAの同定と機能解析

    2012

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Contract research

  • 体液中マイクロRNAの直接定量に基づく新しい病態診断基盤技術の開発

    国立研究開発法人科学技術振興機構  2013

  • インテリジェンス型エクソソームを用いた癌指向性核酸デリバリーシステムの開発

    国立研究開発法人科学技術振興機構  2013

  • インテリジェンス型エクソソームを用いた癌指向性核酸デリバリーシステムの開発

    独立行政法人科学技術振興機構  2012

Incentive donations / subsidies

  • カルボキシルエステラーゼ阻害剤を共力剤とした貯穀害虫ヒラタチャタテの駆除の試み

    飯島藤十郎記念食品科学振興財団  令和5年度飯島藤十郎記念食品科学振興財団学術研究助成  2023.04

  • 食品害虫であるチャタテムシに対する防虫・殺虫効果を有する食用植物由来天然物の探索

    公益財団法人飯島藤十郎記念食品科学振興財団  2020

  • 貯穀害虫チャタテムシに対する駆除法開発へ向けた統合オミクスによる基盤研究

    公益財団法人飯島藤十郎記念食品科学振興財団  2017

  • 体液中マイクロRNAの直接定量に基づく新しい癌診断技術の開発

    公益財団法人黒住医学研究振興財団  黒住医学研究振興財団 第21回研究助成金  2014.04

  • 体液中マイクロRNAの直接定量に基づく新しい癌診断技術の開発

    公益財団法人 黒住医学研究振興財団  黒住医学研究振興財団 第21回研究助成金  2013.04

Acceptance of Researcher

  • 2022  Number of researchers:2

Original item・Special report (Research Activity)

  • 2024

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    Original item:Sigma Xi full member (2024.02~)

Charge of on-campus class subject

  • 生物無機化学

    2023   Weekly class   Undergraduate

  • 生体高分子機能学特論

    2023   Weekly class   Graduate school

  • バイオインフォマティクス特論

    2023   Weekly class   Graduate school

  • ゲノム創薬学

    2023   Intensive lecture   Undergraduate

  • 創薬科学実習II

    2023   Intensive lecture   Undergraduate

  • 創薬科学実習I

    2023   Intensive lecture   Undergraduate

  • 生命機能化学概論

    2023   Weekly class   Undergraduate

  • 生物物理化学実験

    2023   Weekly class   Undergraduate

  • 創薬科学実習1

    2023   Intensive lecture   Undergraduate

  • 創薬科学のすすめ

    2023   Weekly class   Undergraduate

  • バイオインフォマティクス基礎実習

    2023   Weekly class   Undergraduate

  • 科学英語B

    2023   Intensive lecture   Undergraduate

  • 生物物理化学実験

    2023   Weekly class   Undergraduate

  • 基礎化学実験

    2023   Weekly class   Graduate school

  • 生命機能化学研究プレゼンテーション

    2023   Intensive lecture   Graduate school

  • 生命機能化学特論B

    2023   Weekly class   Graduate school

  • 初年次ゼミナール

    2022   Weekly class   Undergraduate

  • 創薬科学のすすめ

    2022   Weekly class   Undergraduate

  • 生体高分子機能学特論

    2022   Weekly class   Graduate school

  • バイオインフォマティクス特論

    2022   Weekly class   Graduate school

  • ゲノム創薬学

    2022   Intensive lecture   Undergraduate

  • 創薬科学実習I

    2022   Intensive lecture   Undergraduate

  • 生命機能化学概論

    2022   Weekly class   Undergraduate

  • 生物無機化学

    2022   Weekly class   Undergraduate

  • 生命機能化学研究プレゼンテーション

    2022   Intensive lecture   Graduate school

  • 生命機能化学特論B

    2022   Weekly class   Graduate school

  • 生物物理化学実験

    2022   Weekly class   Undergraduate

  • 食品衛生学実習

    2022   Intensive lecture   Undergraduate

  • 生命環境科学入門

    2022   Weekly class   Graduate school

  • Genome-based Drug Discovery

    2021    

  • Laboratory Training in Drug Discovery Sciences & Technology I

    2021   Practical Training  

  • Topics in Biological Macromolecules

    2021    

  • Bioinorganic Chemistry

    2021    

  • Introduction of Drug Discovery

    2021    

  • Topics in Life, Environment, and Advanced Sciences

    2021    

  • Topics in Bioinformatics

    2021    

  • General Principles of Applied Biological Chemistry

    2021    

  • Laboratory : Biophysical Chemistry

    2021   Practical Training  

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Number of instructed thesis, researches

  • 2023

    Number of instructed the graduation thesis:Number of graduation thesis reviews:2

    [Number of instructed the Master's Program] (previous term):

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):3

  • 2022

    Number of instructed the graduation thesis:

    [Number of master's thesis reviews] (chief):[Number of master's thesis reviews] (vice-chief):4

Social Activities

  • 公大講座「ダニやカビだけではない~ハウスダスト中に含まれる多様なアレルゲン~」

    Role(s): Lecturer

    大阪公立大学  2023年度公大講座  2023.11

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    SDGs:

    Type:Lecture

  • 大阪女子大学同窓会斐文会・秋の講座「骨粗鬆症のおはなし ~いつまでも健康な骨であるために~」

    Role(s): Lecturer

    大阪女子大学同窓会斐文会  大阪女子大学同窓会斐文会・秋の講座  2023.11

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    SDGs:

    Type:Lecture

    Number of participants:30(人)

  • NPO法人科学映像館を支える会 アドバイザー

    Role(s): Logistic support

    科学映像館  2021.04 - Now

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    Type:Internet

  • 出前講義 コンピュータを用いて探る核酸分子の「かたち」と「役割」

    2019.04 - 2020.03

  • 府大講座 「骨粗鬆症のおはなし ~いつまでも健康な骨であるために~ 」

    2012.04 - 2013.03

Visiting Lectures ⇒ Link to the list of Visiting Lectures

  • コンピュータを用いて探る核酸分子の「かたち」と「役割」

    Category:Agricultural science (applied biology, biofunctional chemistry, green space environmental science), Nursing (nursing, sex education)

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    Audience:Schoolchildren, Junior high school students, High school students, College students, Teachers, Researchers, General, Company, Civic organization

    生物の遺伝情報の担ぎ手であるRNAやDNAといった核酸分子の構造は複雑であり、そのことにより様々な役割・機能を果たしています。世界中の多くの研究者が、その構造や機能を解き明かすために日々実験に励んでいますが、それでもなお解明されていないことは多く残されています。最近、生命科学における情報科学の応用(バイオインフォマティクス)が急速に進み、優れたアルゴリズムが開発されてきたことにより、コンピュータを用いて生体分子の構造や機能を高精度で推測することができるようになりました(in silico解析)。本講義では、核酸分子、特にRNA分子のin silico解析についてわかりやすく解説します。

  • 骨粗鬆症のおはなし ~いつまでも健康な骨であるために~

    Category:Agricultural science (applied biology, biofunctional chemistry, green space environmental science), Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science), Nursing (nursing, sex education)

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    Audience:Schoolchildren, Junior high school students, High school students, College students, Teachers, Researchers, General, Company, Civic organization

    Keyword:骨粗鬆症 

     骨粗鬆症は、骨量が減少し、骨がスカスカで脆くなった状態である。超高齢化時代に突入している日本にとって、今後さらなる増加が予想される骨粗鬆症への対策は喫緊の課題である。骨粗鬆症による骨折は、しばしば寝たきりの原因ともなり、医療のみならず介護・福祉の面でも深刻な問題である。しかし一方で、骨粗鬆症は、日常生活への配慮によって予防が見込める疾患である。この講義では、私達の骨の基本的な構造や役割を説明し、骨粗鬆症発症を防ぐために注意すべき点、さらに、不幸にして発症してしまった場合の治療法に関して概説する。

  • アレルギー性呼吸器疾患の原因 ~ ハウスダストに含まれる多様なアレルゲン

    Category:Life sciences (food, nutrition science, living environment, human welfare), Medicine (medical care, rehabilitation, health exercise science, physical fitness / training, sports practice science)

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    SDGs:

    Audience:Junior high school students, High school students, Guardians, Researchers, General, Scientific organization, Company, Civic organization, Governmental agency, Media

    Keyword:アレルギー;ハウスダスト 

    昆虫等、注目されることのないハウスダストアレルゲンを原因とするアレルギー性疾患についての概説

Academic Activities

  • Cancer Screening and Prevension

    2021.10 - Now

  • Non-coding RNA (MDPI)

    Role(s): Planning, management, etc.

    2021.10 - Now

  • Journal of Bone Metabolism

    2014.08 - Now

  • SM Journal of Gynecology and Obstetrics

    2014 - Now

  • Journal of Dentistry and Oral Health

    2014 - Now

  • Journal of Advanced Techniques in Biology and Medicine

    2013.09 - 2017.08

  • Advances in Medicine

    2013 - 2018.09

  • Datasets Papers in Science

    2012 - 2017.03

▼display all

Foreigner acceptance

  • 2015

    International Students :1

International exchange activities

  • アメリカ国立衛生研究所(NIH)研究員(Dr. S. Muljo & Dr. Z. Islam)との総説論文共同執筆
    DOI: 10.3390/ncrna9060075

    Field category :Research

    Country name :USA   2023.04 - 2023.12

Other

  • バイオインフォマティクス技術者検定試験合格

    2023 - Now

  • 遺伝子分析科学認定士(初級)資格

    2023 - Now

  • 第1種放射線取扱主任者免状

  • エックス線作業主任者資格