Updated on 2024/02/27
Graduate School of Rehabilitation Science Division of Rehabilitation Science
Professor 2022.04 - Now
School of Medicine Department of Rehabilitation Science
Professor 2022.04 - Now
博士（医学） （ Osaka University ）
Life Science / Neuroscience-general / Synaptic plasticity
Life Science / Physiology / Visceral pain and hyperesthesia
neural plasticity
synaptic formation
dendritic spine
restoration of neural function
visceral sensation
hollow organs
epithelial cells
ATP release
シナプス新生シグナル経路の活性化による神経機能回復の促進
管腔臓器の内臓知覚伝達調節機構を利用した内臓知覚過敏の緩和
膀胱や消化管の上皮は膨張するとATPを分泌して伸展感覚を中枢神経に伝達し、尿意や便意、内蔵痛の発生に寄与している。このATP分泌機構を調節するシグナル経路やATP分泌に対する運動の効果を解明することで、尿路系・消化器系の内臓感覚の異常（頻尿・便通異常・排泄痛）を改善する可能性を検討する。
Individual
2008.01 - Now
成熟期の神経系でもシナプスは刺激に応じて新生と消失を活発に繰り返している。我々が海馬で発見したシナプス新生を促進するシグナル系を活性化することで神経機能の再建を効率的に促進できるかどうかを検討し、シナプス新生の促進を利用した運動機能および高次脳機能の新たな機能回復法を確立することを目指す。
Individual
2003.04 - Now
日本生理学会
2009.04 - Now Domestic
日本解剖学会
1994.03 - Now Domestic
日本神経科学学会
1994.06 - Now Domestic
Society for Neuroscience
1996.10 - Now Overseas
日本自律神経学会
2009.10 - Now Domestic
評議員 日本生理学会
2013.03 - Now
学長表彰（教育）
2021.08 大阪府立大学
秋田大学医学部医学科教育賞・優秀教育賞
2011.04 秋田大学医学部
奈良先端科学技術大学院大学バイオサイエンス研究科 助手
1996.04 - 2005.03
チューリッヒ大学生化学部 博士研究員
2003.04 - 2007.08
秋田大学大学院医学系研究科 助教
2008.01 - 2009.04
秋田大学大学院医学系研究科 准教授
2009.04 - 2014.03
関西看護医療大学看護学部 特任准教授
2014.04 - 2016.03
Osaka University Faculty of Human Science Bachelor's Course Graduated/Completed
- 1991.03
Osaka University Graduate School, Division of Medicine Master's Course Graduated/Completed
- 1993.03
Osaka University Graduate School, Division of Medicine Doctor's Course Unfinished Course
- 1996.03
Effects of Cardiac Glycoside Digoxin on Dendritic Spines and Motor Learning Performance in Mice Reviewed
Hashimoto J, Fujita E, Tanimoto K, Kondo S, and Matsumoto-Miyai K.
Neuroscience 541 77 - 90 2024.03（ ISSN:03064522 ）
Social communication of maternal immune activation affected offspring is improved by Si-based hydrogen-producing agent Reviewed
Usui N, Matsumoto-Miyai K, Koyama Y, Kobayashi Y, Nakamura Y, Kobayashi H, and Shimada S.
Front. Psychiatry 13 872302 2022.04
The nitric oxide-cyclic guanosine monophosphate pathway inhibits the bladder ATP release in response to a physiological or pathological stimulus. Reviewed
Okuyama E, Kawatani M, Hashimoto J, Tanimoto K, Hashimoto M, and Matsumoto-Miyai K.
Physiol. Rep. 9 e14938 2021.07
The contribution of peripheral 5-hydroxytryptamine receptors to micturition control.
Nephrology & Urology 6 ( 2 ) 159 - 164 2017.08
Serotonergic regulation of distention-induced ATP release from the urothelium. Reviewed
Matsumoto-Miyai K, Yamada E, Shinzawa E, Koyama Y, Shimada S, Yoshizumi M, and Kawatani M.
Am. J. Physiol. Renal Physiol. 310 F646 - F655 2016.04
Authentic role of ATP signaling in micturition reflex. Reviewed
Takezawa K, Kondo M, Kiuchi H, Ueda N, Soda T, Fukuhara S, Takao T, Miyagawa Y, Tsujimura A, Matsumoto-Miyai K, Ishida Y, Negoro H, Ogawa O, Nonomura N, and Shimada S.
Sci. Rep. 6 2016.01
Regulatory effects of 5-hydroxytryptamine receptors on voiding function. Reviewed
Matsumoto-Miyai K, Yoshizumi M, and Kawatani M.
Adv. Ther. 325 S3 - S15 2015.10
Nerve growth factor and estrogen receptor mRNA expression in paravertebral muscles of patients with adolescent idiopathic scoliosis: a preliminary study. Reviewed
Kudo D, Miyakoshi N, Hongo M, Matsumoto-Miyai K, Kasukawa Y, Misawa A, Ishikawa Y, and Shimada Y.
Spine Deform. 3 122 - 127 2015.03
LBX1 mRNA expression in paravertebral muscles of patients with adolescent idiopathic scoliosis: a preliminary study. Reviewed
Kudo D, Miyakoshi N, Hongo M, Matsumoto-Miyai K, Kasukawa Y, Misawa A, Ishikawa Y, and Shimada Y.
Akita J. Med. 40 151 - 156 2014.08
Activity-controlled proteolytic cleavage at the synapse. Reviewed
Sonderegger P and Matsumoto-Miyai K.
Trends Neurosci. 37 413 - 423 2014.08
Synergistic effects of loxoprofen and glycine on the micturition reflex in conscious rats. Reviewed
Fukiya Y, Yoshizumi M, Saito M, Matsumoto-Miyai K, Nimura T, and Kawatani M.
Biomed. Res. 35 17 - 23 2014.02
膀胱の自律神経支配．
河谷正仁, 松本-宮井和政, 善積克
臨床神経科学 32 ( 12 ) 1363 - 1365 2014.02
膀胱知覚と脊髄の可塑性，最近の知見．
善積克, 松本-宮井和政, 林田健一郎, 河谷正仁
排尿障害プラクティス 21 ( 3 ) 193 - 201 2013.10
The regulation of distention-induced ATP release from urothelium by the adenylyl cyclase-cyclic AMP pathway. Reviewed
Matsumoto-Miyai K, Yamada E, Yoshizumi M, and Kawatani M.
Biomed. Res. 33 153 - 157 2012.06
膀胱上皮からのATP分泌における貯蔵量作動性Ca2+流入とCa2+抑制性アデニル酸シクラーゼの役割．
松本-宮井和政, 河谷正仁
排尿障害プラクティス 20 ( 1 ) 16 - 23 2012.03
Pulse diode laser irradiation (830 nm) of lumbosacral spinal roots diminished hyperreflexia induced by acetic acid or PGE2 infusion in rat urinary bladder. Reviewed
Ito T, Ishikawa T, Matsumoto-Miyai K, and Kawatani M.
LUTS 3 69 - 75 2011.09
Store-operated Ca2+ entry suppresses distention-induced ATP release from urothelium. Reviewed
Matsumoto-Miyai K, Kagase A, Yamada E, Yoshizumi M, Murakami M, Ohba M, and Kawatani M.
Am. J. Physiol. Renal Physiol. 300 F716 - 720 2011.03
Role of supraspinal and spinal α1-adrenergic receptor subtypes in the micturition reflex in conscious rats. Reviewed
Yoshizumi M, Matsumoto-Miyai K, Yonezawa A, and Kawatani M.
Am. J. Physiol. Renal Physiol. 299 F785 - 791 2010.10
カルシウムイオンによる膀胱上皮からのATP分泌の制御機構． Reviewed
松本-宮井和政, 河谷正仁
自律神経 47 ( 5 ) 432 - 435 2010.10
膀胱上皮から分泌されるATPの排尿機能への役割．
松本-宮井和政, 善積克, 河谷正仁
脳21 13 ( 3 ) 247 - 252 2010.07
プロテオリシスによる活動依存的海馬ニューロンフィロポディア誘導機構．
松本-宮井和政
脳21 13 ( 1 ) 22 - 27 2010.01
Extracellular Ca2+ regulates the stimulus-elicited ATP release from urothelium. Reviewed
Matsumoto-Miyai K, Kagase A, Murakawa Y, Momota Y, and Kawatani M.
Auton. Neurosci. 150 94 - 99 2009.10
The urothelial α1D receptor is predominantly involved in the adrenergic facilitation of micturition reflex. Reviewed
Wang X, Matsumoto-Miyai K, Yoshizumi M, Ito T, Yanase H, Momota Y, Tsujimoto G, Tanoue A, and Kawatani M.
LUTS 1 S10 - S14 2009.09
Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Reviewed
Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee C, Lüscher D, Hettwer S, Wölfel J, Ladner A-P, Ster J, Gerber U, Rülicke T, Kunz B, and Sonderegger P.
Cell 136 1161 - 1171 2009.03
NMDA-dependent proteolysis of presynaptic adhesion molecule L1 in the hippocampus by neuropsin. Reviewed
Matsumoto-Miyai K, Ninomiya A, Yamasaki H, Tamura K, Nakamura Y, and Shiosaka S.
J. Neurosci. 23 7727 - 7736 2003.10
Prolonged recovery of ultraviolet B-irradiated skin in neuropsin (KLK8)-deficient mice. Reviewed
Kirihara T, Matsumoto-Miyai K, Nakamura Y, Sadayama T, Yoshida S, and Shiosaka S.
Br. J. Dermatol. 149 700 - 706 2003.10
Distribution and densitometry mapping of L1-CAM Immunoreactivity in the adult mouse brain - light microscopic observation. Reviewed
Munakata H, Nakamura Y, Matsumoto-Miyai K, Itoh K, Yamasaki H, and Shiosaka S.
BMC Neurosci. 4 ( 1 ) 2003.04
Decidualization induces the expression and activation of an extracellular protease neuropsin in mouse uterus. Reviewed
Matsumoto-Miyai K, Kitagawa R, Ninomiya A, Momota Y, Yoshida S, and Shiosaka S.
Biol. Reprod. 67 1414 - 1418 2002.11
Epidermal expression of serine protease, neuropsin (KLK8) in normal and pathological skin samples. Reviewed
Kuwae K, Matsumoto-Miyai K, Yoshida S, Sadayama T, Yoshikawa K, Hosokawa K, and Shiosaka S.
Mol. Pathol. 55 235 - 241 2002.08
Serine proteinase inhibitor 3 and murinoglobulin I are potent inhibitors of neuropsin in adult mouse brain. Reviewed
Kato K, Kishi T, Kamachi T, Akisada M, Oka T, Midorikawa R, Takio K, Dohmae N, Bird PI, Sun J, Scott F, Miyake Y, Yamamoto K, Machida A, Tanaka T, Matsumoto K, Shibata M, and Shiosaka S.
J. Biol. Chem. 276 14562 - 14571 2001.05
Abnormalities of synapses and neurons in the hippocampus of neuropsin-deficient mice. Reviewed
Hirata A, Yoshida S, Inoue N, Matsumoto-Miyai K, Ninomiya A, Taniguchi M, Matsuyama T, Kato K, Iizasa H, Kataoka Y, Yoshida N, and Shiosaka S.
Mol. Cell. Neurosci. 17 600 - 610 2001.03
Effects of fibronectin cleaved by neuropsin on cell adhesion and migration. Reviewed
Tani N, Matsumoto K, Ota I, Yoshida S, Takada Y, Shiosaka S, and Matsuura N.
Neurosci. Res. 39 247 - 251 2001.02
Neuropsin regulates an early phase of Schaffer-collateral long-term potentiation in the murine hippocampus. Reviewed
Komai S, Matsuyama T, Matsumoto K, Kato K, Kobayashi M, Imamura K, Yoshida S, Ugawa S, and Shiosaka S.
Eur. J. Neurosci. 12 1479 - 1486 2000.04
Protease M/neurosin mRNA is expressed in mature oligodendrocytes. Reviewed
Yamanaka H, He X-P, Matsumoto K, Shiosaka S, and Yoshida S.
Mol. Brain Res. 71 217 - 224 1999.08
Crystal structure of neuropsin, a hippocampal protease involved in kindling epileptogenesis. Reviewed
Kishi T, Kato M, Shimizu T, Kato K, Matsumoto K, Yoshida S, Shiosaka S, and Hakoshima T.
J. Biol. Chem. 274 4220 - 4224 1999.02
Immunohistochemical localization of pleiotrophin and midkine in the ligual epithelium of the adult rat. Reviewed
Wakisaka S, Tabata MJ, Maeda T, Matsumoto K, Wanaka A, Muramatsu H, Muramatsu T, and Kurisu K.
Arch. Histol. Cytol. 61 475 - 480 1998.12
Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. Reviewed
Matsumoto K, Ishii N, Yoshida S, Shiosaka S, Wanaka A, and Tohyama M.
Mol. Brain Res. 61 179 - 189 1998.10
Characterization of recombinant and brain neuropsin, a plasticity-related serine protease. Reviewed
Shimizu C, Yoshida S, Shibata M, Kato K, Momota Y, Matsumoto K, Shiosaka T, Midorikawa R, Kamachi T, Kawabe A, and Shiosaka S.
J. Biol. Chem. 273 11189 - 11196 1998.10
Structure and chromosomal localization of a murine LIM/homeobox gene, Lhx8. Reviewed
Kitanaka J-I, Takemura M, Matsumoto K, Mori T, and Wanaka A.
Genomics 49 307 - 309 1998.04
Blockade of neuropsin, a serine protease, ameliorates kindling epilepsy. Reviewed
Momota Y, Yoshida S, Ito J, Shibata M, Kato K, Sakurai K, Matsumoto K, and Shiosaka S.
Eur. J. Neurosci. 10 760 - 764 1998.02
Crystallization and preliminary X-ray analysis of neuropsin, a serine protease expressed in the limbic system of mouse brain. Reviewed
Kishi T, Kato M, Shimizu T, Kato K, Matsumoto K, Yoshida S, Shiosaka S, Hakoshima T.
J. Struct. Biol. 118 248 - 251 1997.04
LIM-homeodomain gene family in neural development. Reviewed
Wanaka A, Matsumoto K, Kashihara Y, Furuyama T, Tanaka T, Mori T, Tanno Y, Yokoya S, Kitanaka J, Takemura M, and Tohyama M.
Dev. Neurosci. 19 97 - 100 1997.01
Localization of bcl-2, bax, and bcl-x mRNAs in the developing inner ear of the mouse. Reviewed
Ishii N, Wanaka A, Ohno K, Matsumoto K, Eguchi Y, Mori T, Tsujimoto Y, and Tohyama M.
Brain Res. 726 123 - 128 1996.07
Differential expression of LIM-homeodomain genes in the embryonic murine brain. Reviewed
Matsumoto K, Tanaka T, Furuyama T, Kashihara Y, Ishii N, Tohyama M, Kitanaka J, Takemura M, Mori T, and Wanaka A.
Neurosci. Lett. 211 147 - 150 1996.06
L3, a novel murine LIM-homeodomain transcription factor expressed in the ventral telencephalon and the mesenchyme surrounding the oral cavity. Reviewed
Matsumoto K, Tanaka T, Furuyama T, Kashihara Y, Mori T, Ishii N, Kitanaka J, Takemura M, Tohyama M, and Wanaka A.
Neurosci. Lett. 204 113 - 116 1996.02
Molecular cloning of novel leucine-rich repeat proteins and their expression in the developing mouse nervous system. Reviewed
Taguchi A, Wanaka A, Imai Y, Mori T, Matsumoto K, Takagi T, and Tohyama M.
Mol. Brain Res. 35 31 - 40 1996.01
Localization of novel receptor tyrosine kinase genes of eph-family, MDK1 and its splicing variant, in the developing mouse nervous system Reviewed
Mori T, Wanaka A, Taguchi A, Matsumoto K, and Tohyama M.
Mol. Brain Res. 34 154 - 160 1995.09
Differential expressions of the eph family of receptor tyrosine kinase genes (sek, elk, eck) in the developing nervous system. Reviewed
Mori T, Wanaka A, Matsumoto K, Taguchi A, Ishii N, and Tohyama M.
Mol. Brain Res. 29 325 - 335 1995.04
Localization of pleiotrophin and midkine in the postnatal developing cerebellum. Reviewed
Matsumoto K, Wanaka A, Mori T, Taguchi A, Ishii N, Muramatsu H, Muramatsu T, and Tohyama M.
Neurosci. Lett. 178 216 - 220 1994.09
Growth factors and extracellular signal-regulated kinases (Mitogen-activated kinase) in the rat pineal grand. Reviewed
Kiyama H, Wanaka A, Kato H, Maeno H, Matsumoto K, Sun G, Shiosaka S, and Tohyama M.
Neuroendocrinology 59 152 - 155 1994.02
A novel heparin-binding growth factor family, pleiotrophin and midkine, is expressed in the developing cerebral cortex. Reviewed
Matsumoto K, Wanaka A, Takatsuji K, Muramatsu H, Muramatsu T, and Tohyama M.
Dev. Brain Res. 79 229 - 241 1994.02
人体の解剖生理学 第2版（木山博資・遠山正彌編集）：単元「栄養摂取の機構」（pp. 239-262)
松本-宮井和政（ Role： Joint author）
金芳堂 2017.04
脳内環境辞典（高橋良輔・山中宏二・樋口真人・漆谷真編集）：単元「ニューロトリプシン」（pp. 72-73）
宮井和政（ Role： Joint author）
メディカルドゥ 2017.03
痛みのScience & Practice シリーズ第6巻 ：痛み診療キーポイント（川真田樹人編集）：単元「内臓痛」「関連痛」（pp. 54-55）
松本-宮井和政、河谷正仁（ Role： Joint author）
文光堂 2014.05
神経因性膀胱ベッドサイドマニュアル（榊原隆次編集）：単元「臨床オリエンテド下部尿路の解剖と生理」（pp. 9-20）
松本-宮井和政、河谷正仁（ Role： Joint author）
中外医学社 2014.05
痛み・しびれ：その原因と対処法（山本隆允編集）：単元「痛み（しびれ）の分類」（pp. 25-30）
松本-宮井和政、河谷正仁（ Role： Joint author）
真興交易㈱医書出版部 2013.11
痛みのScience & Practice シリーズ第2巻 ：痛みの薬物治療（山本達郎編集）：単元「内臓痛のメカニズム」（pp. 50-57）
松本-宮井和政、河谷正仁（ Role： Joint author）
文光堂 2013.07
Advances in Medicine and Biology, Vol. 13 (Berhardt LV ed.): "The Regulatory Mechanism Underlying ATP Release from Urothelium" (pp. 203-215)
Matsumoto-Miyai K, Yoshizumi M, and Kawatani M（ Role： Joint author）
Nova Science Publishers, Inc. 2011.04
動くシナプスと神経ネットワーク（塩坂貞夫編集）：単元「プロテアーゼ－接着分子系を介したシナプス改変機構」（pp. 155-168）
松本-宮井和政、塩坂貞夫（ Role： Joint author）
金芳堂 2003.09
ハイジとスパイの国から Invited
松本-宮井和政
脳21 9 ( 3 ) 345 - 347 2006.07
シナプス新生シグナル経路の活性化による神経機能回復の促進
管腔臓器の内臓知覚伝達調節機構を利用した内臓知覚過敏の緩和
シナプス新生シグナル経路の活性化による神経機能再建の促進
2023
内臓感覚能に対する身体運動の効果とその分子機構の解明
2023
形態機能学実習1
2023 Weekly class Undergraduate
形態機能学1
2023 Weekly class Undergraduate
リハビリテーション学基礎特論
2023 Weekly class Graduate school
理学療法学研究法III
2023 Intensive lecture Undergraduate
理学療法学研究法I
2023 Weekly class Undergraduate
理学療法学研究法II
2023 Intensive lecture Undergraduate
神経解剖学特別講義
2023 Intensive lecture Graduate school
神経解剖学特論
2023 Weekly class Graduate school
微生物学総論
2023 Weekly class Undergraduate
形態機能学実習2
2023 Weekly class Undergraduate
形態機能学2
2023 Weekly class Undergraduate
理学療法学卒業研究
2023 Intensive lecture Undergraduate