Publishing type：Research paper (scientific journal)  

For individuals undergoing psychiatric rehabilitation, there is an urgent need to establish an objective biomarker of brain activity without invasive or behavioral restrictions. To investigate an objective index for potential psychiatric rehabilitation assessment and intervention strategies in the future, we tried to detect the “Berger effect”, the alpha EEG reactivity to eyes opening, and to verify the suitability of a sheet-type electroencephalography (EEG) device, HARU-1. We measured EEG of 20 healthy young to middle-aged subjects using HARU-1 from the forehead area during resting closed-eye and open-eye conditions. Fast Fourier transform and time-frequency analysis were then performed on the data from all subjects in the resting closed-eye and resting open-eye conditions. Statistical analysis found that the reference electrode derivation method showed a significant increase in alpha waves and a significant decrease in beta and gamma waves in the three forehead channels of Fp1, Fp2 and AFz during the resting closed eye condition compared to the resting open eye condition. In the bipolar derivation method, all Fp1-AFz, Fp2-Fp1 and AFz-Fp2 showed a significant decrease in the β and γ bands at approximately 13–50 Hz. These results demonstrated that HARU-1 accurately measured the “Berger effect” in the forehead region, suggesting that HARU-1 may be useful in detecting objective biomarkers of brain activity during psychiatric rehabilitation.

DOI： 10.3389/fpsyt.2025.1503715

PubMed

Publishing type：Research paper (scientific journal)  

Abstract

Introduction:

Chronic low back pain (CLBP) is a global health issue, and its nonspecific causes make treatment challenging. Understanding the neural mechanisms of CLBP should contribute to developing effective therapies.

Objectives:

To compare current source density (CSD) and functional connectivity (FC) extracted from resting electroencephalography (EEG) between patients with CLBP and healthy controls and to examine the correlations between EEG indices and symptoms.

Methods:

Thirty-four patients with CLBP and 34 healthy controls in an open data set were analyzed. Five-minute resting-state closed-eye EEG was acquired using the international 10-20 system. Current source density across frequency bands was calculated using exact low-resolution electromagnetic tomography. Functional connectivity was assessed between 24 cortical regions using lagged linear connectivity. Correlations between pain symptoms and CSD distribution and FC were examined in patients with CLBP.

Results:

Current source density analysis showed no significant differences between the groups. The CLBP group exhibited significantly reduced FC in the β3 band between the left middle temporal gyrus and the posterior cingulate cortex, and between the ventral medial prefrontal cortex and the left inferior parietal lobule. Prefrontal θ and δ activity positively correlated with pain symptoms. Increased β1 band FC between the right dorsolateral prefrontal cortex and right auditory cortex correlated with greater pain intensity.

Conclusions:

We found altered neural activity and connectivity in patients with CLBP, particularly in prefrontal and temporal regions. These results suggest potential targets for pain modulation through brain pathways and highlight the value of EEG biomarkers in understanding pain mechanisms and assessing treatment efficacy.

DOI： 10.1097/pr9.0000000000001233

PubMed

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

Event-related desynchronization (ERD) of the mu rhythm (8-13 Hz) is an important indicator of motor execution, neurofeedback, and brain-computer interface in EEG. This study investigated the feasibility of an ear electroencephalography (EEG) device monitoring mu-ERD during hand grasp and release movements. The EEG data of the right hand movement and the eye opened resting condition were measured with an ear EEG device. We calculated and compared mu rhythm power and time-frequency data from 20 healthy participants during right hand movement and eye opened resting. Our results showed a significant difference of mean mu rhythm power between the eye opened rest condition and the right hand movement condition and significant suppression in the 9-12.5 Hz frequency band in the time-frequency data. These results support the utility of ear EEG in detecting motor activity-related mu-ERD. Ear EEG could be instrumental in refining rehabilitation strategies by providing in-situ assessment of motor function and tailored feedback.

DOI： 10.1371/journal.pone.0321107

PubMed

DOI： 10.3758/s13415-025-01380-3

PubMed

Publishing type：Research paper (scientific journal)  

DOI： 10.1016/j.clinph.2024.11.005

PubMed

Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

DOI： https://doi.org/10.1177/15500594241290858

Publishing type：Research paper (scientific journal)  

DOI： 10.1038/s41598-024-68980-w

PubMed

Other URL： https://www.nature.com/articles/s41598-024-68980-w

これからの介護予防は、地域の通いの場や教室型の介護予防教室だけでなく、スマートフォンなどICT機器を用いた自己による健康管理も推奨されることになり、それに伴い高齢者のデジタルディバイド(情報格差)解消のためのスマホ教室のような地域活動の取り組みも注目されている。今回、大阪公立大学の作業療法専攻の学生と教員らが森之宮第二団地集会所にて「スマホ教室・健康測定会」を実施した。本活動は、地域住民にとってデジタルディバイドの解消や健康管理の意向が向上し、介護予防に貢献できるものである。今後は、各養成校と連携し作業療法士、学生とともにさまざまな地域に展開することも視野にいれたい。(著者抄録)

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

The purpose of this scoping review is to provide updated information on the neural basis and neurophysiological features associated with unilateral spatial neglect (USN) recovery. We applied the Preferred Reporting Systems for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) framework and identified 16 relevant papers from the databases. Critical appraisal was performed by two independent reviewers using a standardized appraisal instrument developed by the PRISMA-ScR. We identified and categorized investigation methods for the neural basis and neurophysiological features of USN recovery after stroke using magnetic resonance imaging (MRI), functional MRI, and electroencephalography (EEG). This review found two brain-level mechanisms underlying USN recovery at the behavioral level. These include the absence of stroke-related damage to the right ventral attention network during the acute phase and compensatory recruitment of analogous areas of the undamaged opposite hemisphere and prefrontal cortex during visual search tasks in the subacute or later phases. However, the relationship between the neural and neurophysiological findings and improvements in USN-related activities of daily living remains unknown. This review adds to the growing body of evidence regarding the neural mechanisms underlying USN recovery.

DOI： 10.1007/s10548-023-00980-x

PubMed

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

INTRODUCTION: The therapeutic structure of occupational therapy (OT) includes groups. Although the presence of others is expected to be relaxing due to the social buffering effect and the tend and befriend theory, it has not been sufficiently validated in accordance with the therapeutic structure of OT. The aim of this study was to investigate the electrophysiological evidence for the effectiveness of parallel groups and states of concentration on craft activities used in OT. METHODS: Thirty healthy young adults were used as controls to measure EEG and autonomic activity during craft activities in three conditions: alone, parallel, and nonparallel. EEG was analyzed using exact low-resolution electromagnetic tomography, and autonomic activity was analyzed using Lorenz plot analysis. RESULTS: Parasympathetic activity was significantly higher in the parallel condition than in the alone condition. A significant negative correlation was found between current source density and parasympathetic activity in the region centered on the right insular cortex in the α1 band, and functional connectivity in regions including the anterior cingulate cortex and insular cortex was associated with autonomic activity. CONCLUSION: Craft activities that occurred during frontal midline theta rhythm also increased parasympathetic activity. The results suggest that the parallel groups used in OT and the intensive state of craft activities induce a social buffering effect that increases parasympathetic activity despite the absence of physical contact or social support. This provides evidence for the effectiveness of the therapeutic structure of occupational activities and groups in OT.

DOI： 10.1159/000531005

PubMed

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

Mu rhythm, also known as the mu wave, occurs on sensorimotor cortex activity at rest, and the frequency range is defined as 8-13Hz, the same frequency as the alpha band. Mu rhythm is a cortical oscillation that can be recorded from the scalp over the primary sensorimotor cortex by electroencephalogram (EEG) and magnetoencephalography (MEG). The subjects of previous mu/beta rhythm studies ranged widely from infants to young and older adults. Furthermore, these subjects were not only healthy people but also patients with various neurological and psychiatric diseases. However, very few studies have referred to the effect of mu/beta rhythm with aging, and there was no literature review about this theme. It is important to review the details of the characteristics of mu/beta rhythm activity in older adults compared with young adults, focusing on age-related mu rhythm changes. By comprehensive review, we found that, compared with young adults, older adults showed mu/beta activity change in four characteristics during voluntary movement, increased event-related desynchronization (ERD), earlier beginning and later end, symmetric pattern of ERD and increased recruitment of cortical areas, and substantially reduced beta event-related desynchronization (ERS). It was also found that mu/beta rhythm patterns of action observation were changing with aging. Future work is needed in order to investigate not only the localization but also the network of mu/beta rhythm in older adults.

DOI： 10.3390/brainsci13050751

PubMed

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

INTRODUCTION: The current study measured the frontal midline theta rhythm (Fmθ), which appears in the frontal midline region during the attentional focus state, using the sheet-type wearable electroencephalograph (EEG) device HARU-1, and examined the modulation of frontal gamma band activity by cognitive tasks. METHODS: We measured the frontal EEG of 20 healthy subjects using HARU-1 for 2 min during the rest eyes-closed condition and simple mental calculation task condition, respectively. Statistical analyses were conducted using permutation testing based on t-test and cluster analysis to compare the results between the resting state and the task condition. RESULTS: Twelve of 20 subjects showed Fmθ during the task condition. The 12 subjects with Fmθ showed significantly higher activity of the theta and gamma bands, and significantly low activity of the alpha band during the task condition compared to the resting condition. In the eight subjects without Fmθ were significantly low activity of the alpha and beta bands and no significant activity in the theta and gamma band activity during the task condition compared to the resting condition. DISCUSSION: These results indicate that it is possible to measure Fmθ using HARU-1. A novel finding was the gamma band activity appearing with Fmθ in the left and right frontal forehead regions, suggesting that it reflects the function of the prefrontal cortex in working memory tasks.

DOI： 10.3389/fnhum.2023.1145282

PubMed

CiNii Research

LORETA法を用いて、手工芸活動中に出現するfrontal midline theta(Fmθ)の発生源および機能的結合性について検討した。健常大学生被験者8名(男性4名、年齢21～22歳)に手工芸活動(3本の刺繍糸を編む)を実施させ、脳波を測定した。Fmθの基準はfrontal midline付近において最大振幅を示す、4～8Hzの正弦波リズムであり、少なくとも1秒以上持続するものとした。大脳皮質における電流源密度分布の解析にはeLORETA法を用いた。その結果、Fmθ発生源は前帯状皮質および前頭葉に存在しており、Δ、θ、α、β、γ帯に多くの機能的結合が存在することが示された。これらの脳活動は手工芸活動に伴う認知制御の瞬間的な向上を反映していることが示唆された。

LORETA法を用いて、手工芸活動中に出現するfrontal midline theta(Fmθ)の発生源および機能的結合性について検討した。健常大学生被験者8名(男性4名、年齢21～22歳)に手工芸活動(3本の刺繍糸を編む)を実施させ、脳波を測定した。Fmθの基準はfrontal midline付近において最大振幅を示す、4～8Hzの正弦波リズムであり、少なくとも1秒以上持続するものとした。大脳皮質における電流源密度分布の解析にはeLORETA法を用いた。その結果、Fmθ発生源は前帯状皮質および前頭葉に存在しており、Δ、θ、α、β、γ帯に多くの機能的結合が存在することが示された。これらの脳活動は手工芸活動に伴う認知制御の瞬間的な向上を反映していることが示唆された。

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

The association between neurocognitive function (NCF) impairment and brain cortical functional connectivity in glioma patients remains unclear. The correlations between brain oscillatory activity or functional connectivity and NCF measured by the Wechsler Adult Intelligence Scale full-scale intelligence quotient scores (WAIS FSIQ), the Wechsler Memory Scale-revised general memory scores (WMS-R GM), and the Western aphasia battery aphasia quotient scores (WAB AQ) were evaluated in 18 patients with left frontal glioma using resting-state electroencephalography (EEG). Current source density (CSD) and lagged phase synchronization (LPS) were analyzed using exact low-resolution electromagnetic tomography (eLORETA). Although 2 and 2 patients scored in the borderline range of WAIS FSIQ and WMS-R GM, respectively, the mean WAIS FSIQ, WMS-R GM, and WAB AQ values of all patients were within normal limits, and none had aphasia. In the correlation analysis, lower WMS-R GM was associated with a higher LPS value between the right anterior prefrontal cortex and the left superior parietal lobule in the beta1 band (13-20 Hz, R = - 0.802, P = 0.012). These findings suggest that LPS evaluated by scalp EEG is associated with memory function in patients with left frontal glioma and mild NCF disorders.

DOI： 10.1038/s41598-022-22493-6

PubMed

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

DOI： 10.11596/asiajot.18.195.

Authorship：Lead author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

DOI： 10.3390/brainsci1202

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

DOI： 10.1038/s41598-021-

ウェアラブルなシート型脳波計(HARU-1)を用い、注意集中状態において前頭正中部に出現するθ律動(Frontal midline theta rhythm:Fmθ)を測定し、作業療法における有用性について検討した。若年から中年の健常者14名に対し、シート型脳波計を用い安静閉眼条件と単純暗算課題条件の前頭部脳波を2分間ずつ測定した。各条件の脳波データに対して2秒間ごとに時間周波数解析を行い、その結果について2つの条件の間で対応のあるt検定を実施した。その結果、14名中7名の被験者で、単純暗算課題条件にFmθの出現が見られた。7名分の時間周波数解析の結果を、安静閉眼条件と比較し、単純暗算課題条件にθ帯域とγ帯域の活動の有意な増大が見られた。HARU-1によって、Fmθに加えてγ帯域活動も観察されたことから、高次脳機能との関連が示唆されているθ-γ連関を捉えたものと考えられた。シート型脳波計による脳波測定が、作業課題遂行時の脳活動の客観的な評価法として有用である可能性が示唆された。(著者抄録)

本症例はCOVID-19重症肺炎に罹患し,長期の気管内挿管,深い鎮静,長期臥床により重篤なICU-Acquired Weakness(ICU-AW)およびADL低下を認めた.我々はCOVID-19リハビリテーションチームを編成し,感染対策および集中的なリハビリテーションを実施したことで,対象者は病前の生活に復帰することができた.本稿の目的は,COVID-19重症肺炎患者1例に対する急性期の作業療法の経験を報告することである.学際的チームアプローチによる作業療法が,集中治療後症候群の重症化を予防し,対象者の日常生活への復帰に貢献したと考えられた.(著者抄録)

Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

DOI： 10.1016/j.clineuro.2

右利きの日本人健常者24名(男性13名、女性11名、平均27.3±6.8歳)を対象に、「テトリス」プレイ中の前頭葉皮質の活性化パターンを、機能的近赤外線分光法を用いて調査した。テトリスのプレイ中に前頭部領域52チャンネルの活性を90秒間測定した。その結果、52チャンネルのうち14チャンネル(26.9%)で有意な活性が認められた。類似した活性パターンを示すチャンネル群を抽出する因子分析により、14チャンネルから2因子(両側外側前頭前野、右前頭前野)が抽出された。さらに、探索的解析により、高成績者では低成績者と比較して、右背外側前頭皮質を中心とする領域の活性が増加し、これらの領域と他の領域との活性の相関が低下していると推定された。以上から、テトリスをプレイすると両側外側前頭前野が有意に活性化することが明らかになった。また、高成績者は低成績者と比較して、右背外側前頭皮質を中心とした領域の活性と他の領域の活性との間の機能的結合性を低下させることで、局所的な活動を増加させている可能性が示唆された。

DOI： 10.1111/psyg.12585

PubMed

事象関連電位(ERP)を用いた研究は、自己の手を見ることで自己参照効果と呼ばれる自己特異的な脳活動が得られるとしているが、視覚的特徴による影響は不明である。本研究の目的は、自己参照効果に対する手の類似性の影響を明らかにすることである。健常な20代の男女25名に対し、手の自他鑑別を行わせる視覚oddball課題を類似度別に2課題実施し、ERP P300と遂行状況を検討した。P300は各課題で明確に誘発され、課題間でP300潜時、振幅、反応時間、エラー数に有意な差を認めた。自己の手に対する自己参照効果は、対照刺激となる手の画像の類似性によって影響を受け、一定ではないことが明らかとなった。自他の手の鑑別課題は、図形の鑑別課題に類似した視覚的情報処理が行われる可能性が示唆された。(著者抄録)