Updated on 2024/03/27

写真a

 
MORITA YOSHITSUGU
 
Organization
Graduate School of Agriculture Department of Applied Biological Chemistry Lecturer
School of Agriculture Department of Applied Biological Chemistry
Title
Lecturer
Affiliation
Institute of Agriculture

Position

  • Graduate School of Agriculture Department of Applied Biological Chemistry 

    Lecturer  2023.04 - Now

  • School of Agriculture Department of Applied Biological Chemistry 

    Lecturer  2023.04 - Now

Degree

  • 博士（工学） （ Osaka University ）

  • 修士（工学） （ Osaka University ）

  • 学士（工学） （ Osaka University ）

Research Areas

  • Nanotechnology/Materials / Bio chemistry

  • Nanotechnology/Materials / Inorganic/coordination chemistry  / Bioinorganic Chemistry

Research Interests

  • Coordination Chemistry

  • Supramolecular Chemistry

  • Bioinorganic Chemistry

  • Biopolymer Chemistry

  • Biofunctional Chemistry

  • Hemoprotein

Professional Memberships

  • Protein Science Society of Japan

    2023.03 - Now

  • 日本化学会 生体機能関連化学部会

    2019.10 - Now

  • The Society of Polymer Science, Japan

    2017.07 - Now

  • Japan Society of Coordination Chemistry

    2011.07 - Now

  • The Chemical Society of Japan

    2008.12 - Now

Awards

  • 第 23 回 瀧野秀雄学術奨励賞

    森田能次

    2020.03   中央大学  

Job Career (off-campus)

  • Osaka Metropolitan University   Department of Applied Biological Chemistry, Graduate School of Agriculture,

    2023.04 - Now

  • Osaka Metropolitan University   Department of Applied Biological Chemistry, Graduate School of Agriculture   Project Researcher

    2022.04 - 2023.03

  • Chuo University   Faculty of Science and Engineering   Research Associate

    2017.04 - 2022.03

Papers

  • O<sub>2</sub> Affinities of Hemoglobin Variants Having a Different Amino Acid at the Position α99 Reviewed

    Y. Morita, R. Yoshida, A. Saito, T. Komatsu

    Chemistry Letters   2023.04（ ISSN:0366-7022 ） （ eISSN:1348-0715 ）

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.230105

  • Zinc Substituted Myoglobin−Albumin Fusion Protein: A Photosensitizer for Cancer Therapy Reviewed

    T. Yamada, Y. Morita, R. Takada, M. Funamoto, W. Okamoto, M. Kohno, T. Komatsu

    29 ( 22 )   e202203952   2023.04

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    Publishing type：Research paper (scientific journal)  

  • An artificial metallolyase with pliable 2-His-1-carboxylate facial triad for stereoselective Michael addition Reviewed

    R. Matsumoto, S. Yoshioka, M. Yuasa, Y. Morita, G. Kurisu, N. Fujieda

    Chem. Sci.   14 ( 14 )   3932 - 3937   2023（ ISSN:20416520 ） （ eISSN:2041-6539 ）

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    Publishing type：Research paper (scientific journal)  

    We repurposed the metal-binding site of a cupin superfamily protein into the 2-His-1-carboxylate facial triad, which is the common motifs in natural non-heme enzymes, to construct artificial metalloenzymes that can catalyze new-to-nature reactions.

    DOI： 10.1039/d2sc06809e

    PubMed

  • Poly(2-ethyl-2-oxazoline)-Conjugated Hemoglobins as a Red Blood Cell Substitute Reviewed

    W. Okamoto, Y. Hiwatashi, T. Kobayashi, Y. Morita, H. Onozawa, M. Iwazaki, M. Kohno, H. Tomiyasu, R. Tochinai, R. Georgieva, H. Bäumler, T. Komatsu

    ACS Applied Bio Materials   2023（ ISSN:2576-6422 ） （ eISSN:2576-6422 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsabm.3c00392

  • 遺伝子組換え融合蛋白質からなる人工酸素運搬体の創製

    森田 能次

    上原記念生命科学財団研究報告集   36   1 - 4   2022.12

  • Genetically and chemically tuned haemoglobin–albumin trimers with superior O<sub>2</sub> transport efficiency Reviewed

    Y. Morita, R. Takada, A. Saito, T. Komatsu

    Chemical Communications   2021.09（ ISSN:1359-7345 ） （ eISSN:1364-548X ）

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    Genetically and chemically tuned haemoglobin–albumin trimers demonstrated haemoglobin allostery and moderately low O<sub>2</sub> affinity, resulting in a higher O<sub>2</sub> transport efficiency compared to red blood cells.

    DOI： 10.1039/d1cc03684j

  • Rectangular Holes in Porphyrin Isomers Act As Mono- And Binucleating Ligands: Stereochemistry of Mono- And Diboron Porphycenes and Their Protonation Behaviors Reviewed

    Ning Xu, Toshikazu Ono, Yoshitsugu Morita, Teruyuki Komatsu, Yoshio Hisaeda

    Inorganic Chemistry   60 ( 2 )   2021（ ISSN:0020-1669 ） （ eISSN:1520-510X ）

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    Publishing type：Research paper (scientific journal)  

    The first boron complexes of porphycenes, structural isomers of porphyrin, are reported. They are synthesized in good yields by reacting the free-base porphycene ligands with BF ·Et O through a microwave-assisted method. Depending on the substituent group of porphycenes, two different coordination structures, mono- and diboron porphycenes, are obtained simultaneously. The single crystal structures and DFT calculations suggest that the boron atom of the monoboron porphycene is favorably coordinated on the dipyrroethene site, and the regioisomer of diboron porphycene is of cisoid stereochemistry, which is more stable than transoid. We also investigate the protonation behavior of boron porphycene complexes. Diboron porphycene does not undergo protonation, whereas monoboron porphycene undergoes protonation at the nonboron coordinating pyrroline site, resulting in a red shift in both absorption and emission spectra. Protonation and deprotonation of monoboron porphycene can be reversibly triggered using acids and bases. 3 2

    DOI： 10.1021/acs.inorgchem.0c01266

    PubMed

  • Protein Triad Comprising Genetically Fused Hemoglobin and Human Serum Albumins as an Artificial O<sub>2</sub> Carrier Resistant to Haptoglobin Binding Reviewed

    Y. Morita, Y. Shindo, T. Komatsu

    2021

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    Authorship：Lead author  

  • Polyelectrolyte/Gold Nanoparticle Nanotube Incorporating Doxorubicin‐Loaded Liposomes Reviewed

    Y. Enomoto, M. Akiyama, Y. Morita, T. Komatsu

    Chemistry – An Asian Journal   2021（ ISSN:1861-4728 ） （ eISSN:1861-471X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/asia.202101109

  • Halogen‐Bonding‐Donor Catalyzed Cyanosilylation of Aldehydes Reviewed

    K. Ueyama, S. Hayakawa, K. Nishio, D. Sawaguchi, K. Niitsuma, S. Michii, R. Tsuruoka, M. Ozawaa, K. Torita, Y. Morita, T. Komatsu, R. Haraguchi, S. Fukuzawa

    Asian J. Org. Chem.   10 ( 7 )   1742 - 1747   2021（ ISSN:2193-5807 ） （ eISSN:2193-5815 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1002/ajoc.202100184

    Other URL： https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.202100184

  • Catalase-Driven Protein Microtube Motors with Different Exterior Surfaces as Ultrasmall Biotools Reviewed

    M. Umebara, N. Sugai, K. Murayama, T. Sugawara, Y. Akashi, Y. Morita, R. Kato, T. Komatsu

    Materials Advances   2021（ eISSN:2633-5409 ）

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    Publishing type：Research paper (scientific journal)  

    We report the synthesis of catalase-driven protein microtube motors with different exterior surfaces. Their abilities of bacteria capture, reaction enhancement by self-stirring, and velocity control with light irradiation were highlighted.

    DOI： 10.1039/d1ma00610j

  • Acid Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino Dithiosulfonate Reviewed

    K. Kanemoto, K. Furuhashi, Y. Morita, T. Komatsu, S. Fukuzawa

    Org. Lett.   23   2021

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    Publishing type：Research paper (scientific journal)  

  • Supramolecular Linear Coordination Polymers of Human Serum Albumin and Haemoglobin Reviewed

    R. Adachi, S. Suzuki, T. Mitsuda, Y. Morita, T. Komatsu

    Chem. Comunn.   56   in press   2020.12

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    Publishing type：Research paper (scientific journal)  

  • Haemoglobin(βK120C)–albumin trimer as an artificial O<sub>2</sub> carrier with sufficient haemoglobin allostery Reviewed

    Y. Morita, A. Saito, J. Yamaguchi, T. Komatsu

    RSC Chemical Biology   1 ( 3 )   128 - 136   2020.08（ eISSN:2633-0679 ）

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    <p>Recombinant haemoglobin [rHb(βK120C)] was coupled with two human serum albumins (HSAs), yielding a rHb(βK120C)–HSA<sub>2</sub> heterotrimer, which shows a sigmoidal O<sub>2</sub> equilibrium curve and sufficient Hb allostery identical to those of native Hb.</p>

    DOI： 10.1039/d0cb00056f

  • Lewis acid–base synergistic catalysis of cationic halogen-bonding-donors with nucleophilic counter anions Reviewed

    K. Torita, R. Haraguchi, Y. Morita, S. Kemmochi, T. Komatsu, S. Fukuzawa

    Chem. Comunn.   56 ( 67 )   9715 - 9718   2020.08

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    Publishing type：Research paper (scientific journal)  

  • Genetically Engineered Haemoglobin Wrapped Covalently with Human Serum Albumins as an Artificial O<sub>2</sub> Carrier Reviewed

    R. Funaki, W. Okamot, C. Endo, Y. Morita, K. Kihira, T. Komatsu

    J. Mater. Chem. B   8   2020.02

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/C9TB02184A

  • Protein Nanoparticles Formed by Self-Assembly of Human Serum Albumin with a Fatty Acid Arm Reviewed

    Y. Morita, D. Takahashi, T. Komatsu

    Chem. Lett.   49 ( 1 )   103 - 106   2020.01

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)  

    DOI： 10.1246/cl.190785

  • Electrocatalytic reactivity of imine/oxime-type cobalt complex for direct perfluoroalkylation of indole and aniline derivatives Reviewed

    Luxia Cui, Toshikazu Ono, Yoshitsugu Morita, Yoshio Hisaeda

    Dalton Transactions   49 ( 22 )   7546 - 7551   2020（ ISSN:1477-9226 ） （ eISSN:1477-9234 ）

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    Publishing type：Research paper (scientific journal)  

    <p>Imine/Oxime-type cobalt complex-catalyzed direct perfluoroalkylation of indole and aniline derivatives with nonafluorobutyl iodide (<italic>n</italic>-C<sub>4</sub>F<sub>9</sub>I) under mild electrochemical method was demonstrated.</p>

    DOI： 10.1039/d0dt01377c

  • Nonbubble‐Propelled Biodegradable Microtube Motors Consisting Only of Protein Reviewed

    N. Sugai, Y. Morita, T. Komatsu

    Chem. Asian J.   14 ( 17 )   2953 - 2957   2019.07

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  • Protein Microtube Motors with a Pt Nanoparticle Interior and Avidin Exterior for Self-Propelled Transportation, Separation, and Stirring Reviewed

    Y. Nakai, N. Sugai, H. Kusano, Y. Morita, T. Komatsu

    ACS Appl. Nano Mater.   2 ( 8 )   4891 - 4899   2019.06

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  • Hemoglobin(βC93A)-Albumin Cluster: Mutation of Cysteine-β93 to Alanine Allows Moderate Reduction of O2 Affinity by Inositol Hexaphosphate. Reviewed

    Y. Morita, K. Igarashi, R. Funaki, T. Komatsu

    ChemBioChem in press   2019.02

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    Authorship：Lead author  

    DOI： 10.1002/cbic.201900079

  • Hemoglobin-Albumin Clusters Prepared using N-Succinimidyl 3-Maleimidopropionate as an Appropriate Crosslinker. Reviewed

    R. Funaki, T. Kashima, W. Okamoto, S. Sakata, Y. Morita, M. Sakata, T. Komatsu

    ACS Omega   4 ( 2 )   3228 - 3233   2019.02

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1021/acsomega.8b03474

  • Esterification of Tertiary Amides by Alcohols Through C-N Bond Cleavage over CeO2 Reviewed

    Takashi Toyao, Md Nurnobi Rashed, Yoshitsugu Morita, Takashi Kamachi, S. M. A. Hakim Siddiki, Md A. Ali, A. S. Touchy, Kenichi Kon, Zen Maeno, Kazunari Yoshizawa, Ken-ichi Shimizu

    CHEMCATCHEM   11 ( 1 )   449 - 456   2019.01（ ISSN:1867-3880 ） （ eISSN:1867-3899 ）

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    Publishing type：Research paper (scientific journal)  

    CeO2 has been found to promote ester forming alcoholysis reactions of tertiary amides. The present catalytic system is operationally simple, recyclable, and it does not require additives. The esterification process displays a wide substrate scope (>45 examples; up to 93% isolated yield). Results of a density functional theory (DFT) study combined with insitu FT-IR observations indicate that the process proceeds through rate limiting addition of a CeO2 lattice oxygen to the carbonyl group of the adsorbed acetamide species with energy barrier of 17.0kcal/mol. This value matches well with experimental value (17.9kcal/mol) obtained from analysis of the Arrhenius plot. Further studies by insitu FT-IR and temperature programmed desorption using probe molecules demonstrate that both acidic and basic properties are important, and consequently, CeO2 showed the best performance for the C-N bond cleavage reaction.

    DOI： 10.1002/cctc.201801098

  • Physicochemical Properties and Crystal Structures of Recombinant Canine and Feline Serum Albumins Reviewed

    KOMATSU Teruyuki, KIHIRA Kiyohito, YAMADA Kana, YOKOMAKU Kyoko, AKIYAMA Motofusa, MORITA Yoshitsugu

    International journal of microgravity science and application   36 ( 1 )   360104:1 - 6   2019.01

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    Publishing type：Research paper (scientific journal)  

    Serum albumin is the most prominent plasma protein in the blood circulatory system and is the main transporter of various compounds. Although ligand binding ability and crystal structure of human serum albumin (HSA) have been widely studied, there are only few reports on serum albumins of companion animals, particularly dogs and cats. This review describes the synthesis, physicochemical properties, and crystal structures of recombinant canine serum albumin (rCSA) and feline serum albumin (rFSA). The rCSA and rFSA were produced in a gram quantity by genetic engineering procedure using Pichia yeast. The proteins show identical features to those of the native CSA and FSA derived from canine and feline plasma. Single crystals of rFSA were prepared under a microgravity environment in the International Space Station. The overall structures of rCSA and rFSA closely resemble to that of HSA. These recombinant serum albumins are anticipated for use as a therapeutic reagent that can be exploited in numerous veterinary medicine situations.

    DOI： 10.15011//jasma.36.360104

    CiNii Article

  • Further Evidence Regarding the Important Role of Chlorine Atoms of Aripiprazole on Binding to the Site II Area of Human Albumin Reviewed

    Keiki Sakurama, Koji Nishi, Shuhei Imoto, Mai Hashimoto, Teruyuki Komatsu, Yoshitsugu Morita, Kazuaki Taguchi, Masaki Otagiri, Keishi Yamasaki

    Journal of Pharmaceutical Sciences   108 ( 5 )   1890 - 1895   2019（ ISSN:0022-3549 ） （ eISSN:1520-6017 ）

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    Publishing type：Research paper (scientific journal)  

    Previously, we reported on the high-affinity binding of aripiprazole (ARP), an antipsychotic drug, to human albumin and the role of the chlorine atom of ARP on this binding. In this study, we investigated the binding mode of ARP to human albumin in detail using ARP derivatives and several animal-derived albumins. ARP bound strongly to human and dog albumin. The circular dichroism (CD) spectra of ARP bound to human and dog albumin were also similar. Deschloro-ARP bound less strongly to all of the albumin species compared to ARP, and the shapes of CD spectra were similar for all albumin species. CD spectra of dimethyl-ARP, for which chlorine atoms were substituted methyl groups, were quite similar to that of deschloro-ARP. In displacement experiments, competitive binding was observed between ARP and deschloro-ARP. These results suggest that the chlorine atoms in ARP are involved in the binding modes of ARP for human and dog albumins, whereas ARP and deschloro-ARP appear to share the same binding region in site II. The aforementioned results imply that compounds having a chlorine atom bind more strongly to plasma proteins, resulting in a long blood retention time. Therefore, findings reported here may provide the basically useful data for drug design.

    DOI： 10.1016/j.xphs.2018.11.045

    PubMed

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Books and Other Publications

  • 赤血球代替物となる人工酸素運搬体の開発（フロンティア機能高分子金属錯体）

    森田能次, 小松晃之（ Role： Contributor）

    編著：西原 寛、山元公寿、三共出版  2020.06 

Presentations

  • アルブミン－ミオグロビン融合タンパク質の合成

    高田諒也, 森田能次, 小松晃之

    第11回CSJ化学フェスタ2021  2021.10 

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    Presentation type：Poster presentation  

  • ビスターピリジン鉄錯体で連結したヘモグロビン超構造体の合成と形態制御

    澤口玲実, 森田能次, 小松晃之

    錯体化学第71回討論会  2021.09 

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    Presentation type：Poster presentation  

  • 酸素吸脱着により構造変化する組換えヘモグロビン集合体の合成

    吉田瑠佳, 森田能次, 小松晃之

    錯体化学第71回討論会  2021.09 

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    Presentation type：Poster presentation  

  • Synthesis and O2 affinity control of recombinant human hemoglobin nanoparticles

    T. Kobayashi, W. Okamoto, M. Hasegawa, Y. Morita, T. Komatsu

    2021.09 

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    Presentation type：Poster presentation  

  • 協同効果を有する人工酸素運搬体（ヘモグロビン-アルブミン）トリマーの合成と酸素親和性制御 Invited

    森田能次, 小松晃之

    第70回高分子討論会  2021.09 

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    Presentation type：Oral presentation (invited, special)  

  • ポリオキサゾリン修飾ブタ血清アルブミンの合成

    臼井朝音, 岡本航, 森田能次, 河野光智, 小松晃之

    日本化学会第101春季年会  2021.03 

  • 換えヒトヘモグロビンナノ粒子の合成と酸素結合能

    小林樹広, 岡本航, 長谷川舞, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.03 

  • 協同的酸素結合能を有する（ヘモグロビン—アルブミン）トリマーの合成

    高田諒也, 齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.03 

  • 酸素結合解離に応答して構造が変化するヘモグロビンオリゴマーの合成

    森田能次, 大熊千夏, 小松晃之

    日本化学会第101春季年会  2021.03 

  • 金ナノ粒子で被覆したカタラーゼマイクロチューブモーターの合成と光照射による速度制御

    菅原智直, 加藤遼, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.03 

  • Lys-α99置換ヘモグロビン変異体の合成と酸素親和性

    吉田瑠佳, 齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第101春季年会  2021.03 

  • アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成

    森田能次, 高田諒也, 齊藤飛鳥, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

  • ポリオキサゾリン修飾ヘモグロビン（Hemoxa™）の合成と有効性評価

    樋渡侑樹, 岡本航, 橋本諒, 小野沢博登, 河野光智, 岩﨑正之, 森田能次, 小松晃之

    第27回日本血液代替物学会年次大会  2020.12 

  • 修飾ヘモグロビン・組換えヘモグロビンを用いた人工酸素運搬体製剤の新展開　アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成

    森田 能次, 高田 諒也, 齊藤 飛鳥, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • ポリオキサゾリン修飾ヘモグロビン(Hemoxa)の合成と有効性評価

    樋渡 侑樹, 岡本 航, 橋本 諒, 小野沢 博登, 河野 光智, 岩崎 正之, 森田 能次, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • ポリオキサゾリン修飾ヘモグロビン(Hemoxa)の合成と有効性評価

    樋渡 侑樹, 岡本 航, 橋本 諒, 小野沢 博登, 河野 光智, 岩崎 正之, 森田 能次, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • 修飾ヘモグロビン・組換えヘモグロビンを用いた人工酸素運搬体製剤の新展開　アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成

    森田 能次, 高田 諒也, 齊藤 飛鳥, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • 修飾ヘモグロビン・組換えヘモグロビンを用いた人工酸素運搬体製剤の新展開　アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成

    森田 能次, 高田 諒也, 齊藤 飛鳥, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • ポリオキサゾリン修飾ヘモグロビン(Hemoxa)の合成と有効性評価

    樋渡 侑樹, 岡本 航, 橋本 諒, 小野沢 博登, 河野 光智, 岩崎 正之, 森田 能次, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • 修飾ヘモグロビン・組換えヘモグロビンを用いた人工酸素運搬体製剤の新展開　アロステリック効果を有する組換えヘモグロビン-アルブミントリマーの合成

    森田 能次, 高田 諒也, 齊藤 飛鳥, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • ポリオキサゾリン修飾ヘモグロビン(Hemoxa)の合成と有効性評価

    樋渡 侑樹, 岡本 航, 橋本 諒, 小野沢 博登, 河野 光智, 岩崎 正之, 森田 能次, 小松 晃之

    人工血液  2020.11  日本血液代替物学会

  • ビスターピリジン鉄錯体で連結した組換えヘモグロビンナノファイバーの合成

    澤口玲実, 髙橋大輝, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • 変異導入による（組換えヘモグロビン－アルブミン）トリマーの酸素親和性制御

    高田諒也, 齋藤飛鳥, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • ポリオキサゾリンで被覆したヘモグロビンの合成と酸素結合能

    樋渡侑樹, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • ヘモグロビンナノ粒子の合成と酸素結合能

    長谷川舞, 岡本航, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • Synthesis and O2 Binding Property of Recombinant Cross-Linked Hemoglobin-Albumin Trimer with Cooperativity

    Y. Morita, Y. Shindo, T. Komatsu

    日本化学会第100春季年会  2020.03 

  • 自己攪拌能を有するα-グルコシターゼマイクロチューブモーターの合成

    梅原瑞希, 菅井夏穂, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • 化学修飾による（組換えヘモグロビン-アルブミン）トリマーの酸素親和性制御

    齋藤飛鳥, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • ポリアクリル酸で被覆した蛋白質マイクロチューブモーターの合成と機能

    内藤圭吾, 菅井夏穂, 森田能次, 小松晃之

    日本化学会第100春季年会  2020.03 

  • Efficient Synthesis Proceduere of Hemoglobin-Albumin Cluster “HemoActTM”

    T. Hamano, S. Sakata, R, Funaki, Y. Morita, T. Komatsu

    The 17th International Symposium on Blood Substitutes and Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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    Presentation type：Poster presentation  

  • Synthesis and Oxygen Binding Property of Recombinant Hemoglobin(βC93A)-Albumin Cluster “HemoActTM” with Allosteric Effect of Inositol Hexaphosphate

    Y. Morita, T. Komatsu

    The 17th International Symposium on Blood Substitutes and Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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    Presentation type：Poster presentation  

  • Recombinant Hemoglobin-Albumin Cluster “HemoActTM” as an Entirely Synthetic O2 Carrier

    R. Funaki, W. Okamoto, C. Endo, Y. Morita, K. Kihira, T. Komatsu

    The 17th International Symposium on Blood Substitutes and Oxygen Therapeutics (XVII-ISBS-2019)  2019.11 

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    Presentation type：Poster presentation  

  • アロステリック効果を有する（ヘモグロビン（βK120C）-アルブミン）トリマーの合成と酸素結合パラメーター

    齊藤飛鳥, 森田能次, 小松晃之

    第９回CSJ化学フェスタ2019  2019.10 

  • 大腸菌捕捉能を有するレクチン/カタラーゼマイクロチューブモーターの合成

    菅井夏穂, 森田能次, 小松晃之

    第９回CSJ化学フェスタ2019  2019.10 

  • バクテリア捕集能を有するカタラーゼマイクロチューブモータの合成

    菅井夏穂, 森田能次, 小松晃之

    2019.09 

  • ビスマレイミド架橋剤で連結したヘモグロビンオリゴマーの合成と酸素結合能

    高橋大輝, 森田能次, 小松晃之

    第68回高分子討論会  2019.09 

  • 協同性を保持した（ヘモグロビン（βK120C）-アルブミン）トリマーの合成と酸素結合能

    齊藤飛鳥, 森田能次, 小松晃之

    錯体化学会第68回討論会  2019.09 

  • （遠位アミノ酸置換ヘモグロビン-アルブミン）クラスターの合成と酸素結合能

    岡本 航, 遠藤千尋, 船木亮佑, 森田能次, 小松晃之

    錯体化学会第69回討論会  2019.09 

  • Synthesis and Drug Binding Properties of Recombinant Canine Serum Albumin

    T. Hasegawa, Y. Morita, T. Komatsu

    International Conference on Materials Science and Engineering (Materials Oceania)  2019.09 

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    Presentation type：Poster presentation  

  • アロステリック効果を有する人工酸素運搬体の開発 Invited

    森田能次

    第32回生物無機化学夏季セミナー  2019.09 

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    Presentation type：Oral presentation (invited, special)  

  • 協同的酸素結合能を有する（ヘモグロビン-アルブミン）トリマーの合成

    森田能次, 齊藤飛鳥, 小松晃之

    第13回バイオ関連化学シンポジウム2019  2019.09 

  • Hemoglobin (βC93A)-Albumin Cluster with Moderate Allosteric Effect by Inositol Hexaphosphate

    Y. Morita, T. Komatsu

    19th International Conference on Biological Inoerganic Chemistry (ISBIC-19)  2019.08 

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    Presentation type：Oral presentation (general)  

  • O2-Binidng Property of Recombinnat Hemoglobin(βC93A)-Albumin Cluster as a Red Blood Cell Substitute

    Y. Morita, T. Komatsu

    2019.06 

  • Synthesis and O2-Binidng Property of Distal Amino Acid Mutated Hemoglobin-Albumin Cluster

    R. Funaki, W. Okamoto, Y. Morita, T. Komatsu

    2019.06 

  • ポリオキサゾリン修飾ヘモグロビンの合成および酸素結合能

    樋渡佑樹, 森田能次, 小松晃之

    第68回高分子学会年次大会  2019.05 

  • 遠藤千尋、船木亮佑、森田能次、小松晃之、遠位アミノ酸を置換した組換え（ヘモグロビン-アルブミン）クラスターの合成と酸素親和性

    遠藤千尋, 船木亮佑, 森田能次, 小松晃之

    第68回高分子学会年次大会  2019.05 

  • Synthesis and Oxygen Affinity of Hemoglobin(βC93A)-Albumin Cluster

    Y. Morita, K. Igarashi, T. Komatsu

    日本化学会第99春季年会  2019.03 

  • （ヘモグロビン（βL28変異体）-アルブミン）クラスターの合成と酸素結合能

    岡本 航, 船木亮佑, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.03 

  • （ヘモグロビン（βK120C）-アルブミン）トリマーの合成

    齊藤飛鳥, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.03 

  • 外表面をアビジンで被覆した蛋白質マイクロチューブモーターの合成と機能

    菅井夏穂, 中井葉子, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.03 

  • 人工酸素運搬体（ヒトヘモグロビン-アルブミン）クラスターの調製

    濱野辰彦, 坂田 翔, 鹿島知周, 船木亮佑, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.03 

  • ビスマレイミド架橋剤を用いたヘモグロビン重合体の合成

    高橋大輝, 森田能次, 小松晃之

    日本化学会第99春季年会  2019.03 

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Industrial Property Rights

  • ポリオキサゾリン結合ヘモグロビン及び人工酸素運搬体

    小松 晃之, 森田 能次

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    property_type：Patent 

    Application no：特願2019-045253 

    Announcement no：特開2020-147515 

    J-GLOBAL

Grant-in-Aid for Scientific Research

  • Functional Controlling of Artificial Metalloenzymes Using Synthetic Polymers

    Grant-in-Aid for Early-Career Scientists  2024

  • 合成高分子を利用した人工金属酵素の合理的な機能制御手法の開発

    2023

  • 指向性進化法による超高発現融合タンパク質の合理的設計と合成

    2023

Charge of on-campus class subject

  • 生物物理化学実験

    2024   Weekly class   Undergraduate

  • 生命機能化学概論

    2024   Weekly class   Undergraduate

  • 生物物理化学特論

    2024   Weekly class   Graduate school

  • 初年次ゼミナール

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  • 生物物理化学実験

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  • 生物物理化学特論

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  • 生命機能化学概論

    2023   Weekly class   Undergraduate

  • 生物物理化学実験

    2023   Weekly class   Undergraduate

  • 基礎化学実験

    2023   Weekly class   Graduate school

  • 生物物理化学2

    2023   Weekly class   Undergraduate

  • 生物物理化学実験

    2023   Weekly class   Undergraduate

  • 生命機能化学研究プレゼンテーション

    2023   Intensive lecture   Graduate school

  • 生命機能化学特論B

    2023   Weekly class   Graduate school

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