Updated on 2026/07/23

写真a

 
MATSUDA SHINYA
 
Organization
Graduate School of Science Department of Biology Assistant Professor
School of Science Department of Biology
Title
Assistant Professor
Affiliation
Institute of Science
Homepage
https://www.omu.ac.jp/sci/biol-cellpombe/
Affiliation campus
Sugimoto Campus

Position

  • Graduate School of Science Department of Biology 

    Assistant Professor  2025.04 - Now

  • School of Science Department of Biology 

    Assistant Professor  2025.04 - Now

Degree

  • 博士（工学） （ The University of Tokushima ）

Research Areas

  • Life Science / Cell biology

  • Life Science / Applied biochemistry

  • Life Science / Molecular biology

Research Interests

  • 細胞運動

  • 細胞内シグナル伝達

  • 減数分裂

  • 天然物生合成遺伝子

  • 分裂酵母

  • Target of rapamycin (TOR)

  • アクチン

  • オートファジー

  • サイクリン依存性キナーゼ

  • テトラヒメナ

  • ヒト培養細胞

Professional Memberships

  • 日本細胞生物学会

    2023.04 - Now

  • 酵母遺伝学フォーラム

  • JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

  • THE MOLECULAR BIOLOGY SOCIETY OF JAPAN

Committee Memberships (off-campus)

  • 酵母遺伝資源運営委員会   運営委員  

    2026.04 - Now 

Job Career (off-campus)

  • University of Tsukuba   Faculty of Life and Environmental Sciences

    2021.09 - 2025.03

  • 静岡県立大学   薬学部   特任助教

    2020.04 - 2021.08

  • 神戸大学   バイオシグナル総合研究センター   研究機関研究員

    2017.04 - 2020.03

Papers

  • mTOR‐Dependent Autophagy Is Conserved in the Ciliate Tetrahymena thermophila Reviewed

    Shinya Matsuda, Kentaro Nakano

    Journal of Eukaryotic Microbiology   73 ( 3 )   e70086   2026.05（ ISSN:1066-5234 ） （ eISSN:1550-7408 ）

    　More details

    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)  

    ABSTRACT

    In Tetrahymena , autophagy appears to be involved in the integrity of the mitochondria which supply energy for active ciliary movement on the cell surface, the maintenance of various structures such as cilia, and cell shape changes associated with starvation. In this organism, which is evolutionarily distant from yeast and animal cells, the mechanisms controlling autophagy remain largely unknown. mTOR is a major regulatory factor that suppresses autophagy induction when cells are under nutrient‐rich conditions. Previous studies suggest that T. thermophila contains two mTOR orthologs, but lacks the canonical TORC1 subunits, while retaining TORC2‐associated components. To determine whether mTOR controls autophagy in T. thermophila , we examined Torin1, an ATP‐competitive inhibitor that blocks mTOR kinase activity regardless of complex composition. It markedly triggered ATG8 puncta formation and mitochondrial degradation under nutrient‐rich conditions. In contrast, rapamycin, a TORC1‐specific inhibitor widely used to induce autophagy, did not affect cell growth or autophagy. These findings demonstrate that mTOR functions as a negative regulator of autophagy in T. thermophila , likely through a rapamycin‐insensitive TORC2 or noncanonical complex. Our results highlight lineage‐specific divergence in mTOR signaling architecture and expand our understanding of the diversity of autophagy regulation across eukaryotes.

    DOI： 10.1111/jeu.70086

    PubMed

    Other URL： https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jeu.70086

  • Metabolic Flux Control Enhances Intracellular Biosynthesis of Fumagillin Derivatives in Human Cells Reviewed

    Shinya Matsuda

    Bioscience, Biotechnology, and Biochemistry   90 ( 7 )   919 - 922   2026.04（ ISSN:0916-8451 ）

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    Authorship：Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Intracellular biosynthesis of natural products in human cells represents a promising strategy for functional drug delivery. Here we engineered production of fumagillin metabolites in human cells expressing fungal cytochrome P450 Fma-P450. In endothelial-derived EA.hy926 cells, metabolic flux optimization enhanced metabolite production and enabled detection of cytotoxic activity.

    DOI： 10.1093/bbb/zbag061

    PubMed

  • Tetrahymena ATG8 homologs, TtATG8A and TtATG8B, are responsible for mitochondrial degradation induced by starvation. Reviewed OA

    Shinya Matsuda, Chieko Saito, Mami Nomura, Hitomi Kawahara, Noboru Mizushima, Kentaro Nakano

    2025.05

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1128/mbio.00783-25

    Repository URL： http://hdl.handle.net/10466/0002003932

  • 天然物生合成機能の発現による新しい遺伝子治療 Reviewed

    松田 真弥, 渡辺 賢二

    有機合成化学協会誌   80 ( 8 )   747 - 754   2022.08

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    Authorship：Lead author   Publishing type：Research paper (other academic)   International / domestic magazine：Domestic journal  

    DOI： 10.5059/yukigoseikyokaishi.80.747

  • Toward engineered biosynthesis of drugs in human cells Reviewed

    Shinya Matsuda, Yuta Tsunematsu, Takuma Matsushita, Yuji Ogata, Shihomi Hachiya, Shinji Kishimoto, Noriyuki Miyoshi, Kenji Watanabe

    ChemBioChem   23 ( 4 )   e202100645   2021.12

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1002/cbic.202100645

  • The S. pombe CDK5 Orthologue Pef1 Cooperates with Three Cyclins, Clg1, Pas1 and Psl1, to Promote Pre-Meiotic DNA Replication Reviewed

    Shinya Matsuda, Ushio Kikkawa, Akio Nakashima

    Biomolecules   11 ( 1 )   2021.01

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.3390/biom11010089

  • The S. pombe CDK5 ortholog Pef1 regulates sexual differentiation through control of the TORC1 pathway and autophagy Reviewed

    Shinya Matsuda, Ushio Kikkawa, Haruka Uda, Akio Nakashima

    Journal of Cell Science   2020.09

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    Authorship：Lead author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1242/jcs.247817

  • Alisol B, a triterpene from Alismatis rhizoma (dried rhizome of Alisma orientale), inhibits melanin production in murine B16 melanoma cells Reviewed

    Ichiro Yoshida, Chihiro Ito, Shinya Matsuda, Akihiko Tsuji, Noriyuki Yanaka, Keizo Yuasa

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   81 ( 3 )   534 - 540   2017.03

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1080/09168451.2016.12

  • PCTK3/CDK18 regulates cell migration and adhesion by negatively modulating FAK activity Reviewed

    Shinya Matsuda, Kohei Kawamoto, Kenji Miyamoto, Akihiko Tsuji, Keizo Yuasa

    SCIENTIFIC REPORTS   7   2017.03

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1038/srep45545

  • Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II Reviewed International coauthorship

    James C. Campbell Jeong Joo Kim Kevin Y. Li Gilbert Y. Huang Albert S. Reger Shinya Matsuda Banumathi Sankaran Todd M. Link Keizo Yuasa John E. Ladbury Darren E. Casteel Choel Kim

    JOURNAL OF BIOLOGICAL CHEMISTRY   291 ( 11 )   5623 - 5633   2016.03

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1074/jbc.M115.691303

  • Death-associated protein kinase 2 mediates nocodazole-induced apoptosis through interaction with tubulin Reviewed

    Kinuka Isshiki, Taishi Hirase, Shinya Matsuda, Kenji Miyamoto, Akihiko Tsuji, Keizo Yuasa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   468 ( 1 )   113 - 118   2015.12

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.bbrc.2015.10.151

  • Suppression of death-associated protein kinase 2 by interaction with 14-3-3 proteins Reviewed

    Keizo Yuasa, Reina Ota, Shinya Matsuda, Kinuka Isshiki, Masahiro Inoue, Akihiko Tsuji

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   464 ( 1 )   70 - 75   2015.08

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.bbrc.2015.05.105

  • PCTAIRE Kinase 3/Cyclin-dependent Kinase 18 Is Activated through Association with Cyclin A and/or Phosphorylation by Protein Kinase A Reviewed

    Shinya Matsuda, Kyohei Kominato, Shizuyo Koide-Yoshida, Kenji Miyamoto, Kinuka Isshiki, Akihiko Tsuji, Keizo Yuasa

    JOURNAL OF BIOLOGICAL CHEMISTRY   289 ( 26 )   18387 - 18400   2014.06

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    Authorship：Lead author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1074/jbc.M113.542936

  • Engineering of α1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis. Reviewed

    Hada K, Isshiki K, Matsuda S, Yuasa K, Tsuji A

    Protein engineering, design & selection : PEDS   26 ( 2 )   123 - 131   2013.02

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1093/protein/gzs091

  • cGMP-dependent protein kinase I promotes cell apoptosis through hyperactivation of death-associated protein kinase 2 Reviewed

    Kinuka Isshiki, Shinya Matsuda, Akihiko Tsuji, Keizo Yuasa

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   422 ( 2 )   280 - 284   2012.06

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.bbrc.2012.04.148

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MISC

  • Development of gene therapy by natural product biosynthetic genes

    松田真弥

    月刊メディカル・サイエンス・ダイジェスト   50 ( 2 )   2024（ ISSN:1347-4340 ）

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Presentations

  • 分裂酵母の細胞膜の溝を形成するBAR ドメインタンパ ク質Pil1 とPil2 の使い分け

    井川 希美, 松田 真弥, 中村 太郎

    日本農芸化学会 2026年度大会  2026.03 

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    Presentation type：Oral presentation (general)  

  • テトラヒメナの細胞質分裂に必要な新規遺伝子の同定

    山木佳奈子, 松田真弥, Wolfgang Maier, Jacek Gaertig, 中野賢太郎

    生体運動研究合同班会議 2026  2026.01 

  • テトラヒメナの繊毛運動を制御する新奇アクチン関連タンパク質 tArp

    加川海来, 萩田美乃里, 中山卓郎, 柴小菊, 箕浦高子, 松田真弥, 稲葉一男, 稲垣祐司, 中野賢太郎

    生体運動研究合同班会議 2026  2026.01 

  • テトラヒメナの細胞質分裂の新奇分子機構の解明

    山木 佳奈子, 松田 真弥, Maier Wolfgang, Gaertig Jacek, 中野 賢太郎

    第48回日本分子生物学会年会  2025.12 

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    Presentation type：Poster presentation  

  • 繊毛虫テトラヒメナにおけるTORシグナルを介したオートファジーとミトコンドリア分解機構の解析

    松田 真弥, 中野 賢太郎

    第48回日本分子生物学会年会  2025.12 

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    Presentation type：Poster presentation  

  • 分裂酵母の胞子で形成される凸凹とαグルカンの関係

    加藤智也, 松田真弥, 中村太郎

    第42回YEAST WORKSHOP  2025.11 

  • 溝構造形成タンパク質Pil2が胞子膜へ局在するメカニズム

    井川希美, 松田真弥, 中村太郎

    第42回YEAST WORKSHOP  2025.11 

  • 分裂酵母における脂質輸送タンパク質Vps13パラログの機能解析

    志賀翔吾, 松田真弥, 中村太郎

    第42回YEAST WORKSHOP  2025.11 

  • Cyclin-dependent kinase Pef1 promotes meiosis in Shizosaccharomyces pombe.

    Shinya Matsuda, Taro Nakamura, Akio Nakashima

    The 12th International Fission Yeasts Meeting  2025.08 

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    Presentation type：Poster presentation  

  • tARP is an actin-related protein required for ciliary function that is conserved in ciliates and related eukaryotic groups

    Miku Kagawa, Minori Hagita, Takuro Nakayama, Kogiku Shiba, Takako Kato-Minoura, Shinya Matsuda, Kazuo Inaba, Yuji Inagaki, Kentaro Nakano

    Joint Meeting of JSCB 77th & JSDB 58th  2025.07 

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    Presentation type：Poster presentation  

  • Cellular responses to starvation in the ciliate Tetrahymena: focus on mitochondrial degradation Invited

    Shinya Matsuda, Chieko Saito, Mami Nomura, Hitomi Kawahara, Noboru Mizushima, Kentaro Nakano

    Joint Meeting of JSCB 77th & JSDB 58th  2025.07 

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    Presentation type：Symposium, workshop panel (nominated)  

  • Identification of the gene responsible for the cytokinetic mutant cdaC in the ciliate Tetrahymena thermophila

    Kanako Yamaki, Shinya Matsuda, Wolfgang Maier, Jacek Gaertig, Kentaro Nakano

    Joint Meeting of JSCB 77th JSDB 58th  2025.07 

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    Presentation type：Poster presentation  

  • 分裂酵母サイクリン依存性キナーゼPef1による接合制御機構の解析

    松田真弥, 森山直人, 森田陸離, 中嶋昭雄, 中野賢太郎

    第57回酵母遺伝学フォーラム  2024.09 

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    Presentation type：Oral presentation (general)  

  • 分裂酵母のサイクリン依存性キナーゼ Pef1 による接合制御機構の解析

    森山 直人, 森田 陸離, 中野 賢太郎, 松田 真弥

    第76回日本細胞生物学会大会  2024.07 

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    Presentation type：Poster presentation  

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Grant-in-Aid for Scientific Research

  • Study of the molecular mechanisms that guarantee the functional quality and quantity of the actin cytoskeleton

    Grant-in-Aid for Scientific Research(C)  2026

  • 分子動力学計算とモデル生物で導き出す減数分裂開始機構の実態

    Grant-in-Aid for Scientific Research(C)  2025

  • Study of the molecular mechanisms that guarantee the functional quality and quantity of the actin cytoskeleton

    Grant-in-Aid for Scientific Research(C)  2025

Charge of on-campus class subject

  • 生物学特別研究5A

    2026   Intensive lecture   Graduate school

  • 生物学特別研究4A

    2026   Intensive lecture   Graduate school

  • 生物学特別研究3A

    2026   Intensive lecture   Graduate school

  • 生物学特別演習2A

    2026   Intensive lecture   Graduate school

  • 生物学特別演習1A

    2026   Intensive lecture   Graduate school

  • 生物学特別研究2A

    2026   Intensive lecture   Graduate school

  • 生物学特別研究1A

    2026   Intensive lecture   Graduate school

  • 生体機能生物学演習2A

    2026   Intensive lecture   Graduate school

  • 生体機能生物学演習1A

    2026   Intensive lecture   Graduate school

  • 生物学卒業研究A

    2026   Intensive lecture   Undergraduate

  • 生物学卒業演習A

    2026   Intensive lecture   Undergraduate

  • 専門生物学実験1

    2026   Weekly class   Undergraduate

  • 細胞生物学4

    2026   Weekly class   Undergraduate

  • 生物学の潮流

    2026   Weekly class   Undergraduate

  • 生体機能生物学演習1B

    2025   Intensive lecture   Graduate school

  • 生体機能生物学演習2B

    2025   Intensive lecture   Graduate school

  • 海外特別研究1

    2025   Intensive lecture   Graduate school

  • 海外特別研究2

    2025   Intensive lecture   Graduate school

  • 生物学特別研究1B

    2025   Intensive lecture   Graduate school

  • 生物学特別研究2B

    2025   Intensive lecture   Graduate school

  • 生物学特別演習1B

    2025   Intensive lecture   Graduate school

  • 生物学特別演習2B

    2025   Intensive lecture   Graduate school

  • 専門生物学実験2

    2025   Intensive lecture   Undergraduate

  • 生物学卒業演習B

    2025   Intensive lecture   Undergraduate

  • 生物学卒業研究B

    2025   Intensive lecture   Undergraduate

  • 生物学実験B

    2025   Weekly class   Undergraduate

  • 生体機能生物学ゼミナール

    2025   Intensive lecture   Graduate school

  • 生体機能生物学特別演習

    2025   Intensive lecture   Graduate school

  • 海外特別研究3

    2025   Intensive lecture   Graduate school

  • 海外特別研究4

    2025   Intensive lecture   Graduate school

  • 海外特別研究5

    2025   Intensive lecture   Graduate school

  • 生物学特別研究3B

    2025   Intensive lecture   Graduate school

  • 生物学特別研究4B

    2025   Intensive lecture   Graduate school

  • 生物学特別研究5B

    2025   Intensive lecture   Graduate school

  • 生体機能生物学演習1A

    2025   Intensive lecture   Graduate school

  • 生体機能生物学演習2A

    2025   Intensive lecture   Graduate school

  • 生物学特別研究1A

    2025   Intensive lecture   Graduate school

  • 生物学特別研究2A

    2025   Intensive lecture   Graduate school

  • 生物学特別演習1A

    2025   Intensive lecture   Graduate school

  • 生物学特別演習2A

    2025   Intensive lecture   Graduate school

  • 生物学特別研究3A

    2025   Intensive lecture   Graduate school

  • 生物学特別研究4A

    2025   Intensive lecture   Graduate school

  • 生物学特別研究5A

    2025   Intensive lecture   Graduate school

  • 生物学の潮流

    2025   Weekly class   Undergraduate

  • 専門生物学実験1

    2025   Weekly class   Undergraduate

  • 生物学卒業演習A

    2025   Intensive lecture   Undergraduate

  • 生物学卒業研究A

    2025   Intensive lecture   Undergraduate

▼display all

Charge of off-campus class subject

  • _

    2022
    -
    2025
    Institution：University of Tsukuba

  • 基礎生物学実験

    2021
    -
    2025
    Institution：University of Tsukuba

  • 細胞生物学実験

    2021
    -
    2025
    Institution：University of Tsukuba

Social Activities　⇒ Link to the list of Social Activities

  • 第10回サイエンス・ギャラリー（高校生ポスター発表会）

    Role(s)： Consultant

    Type： Science festival

    奈良県立青翔高等学校  2025.07

  • 茨城県高校生科学研究発表会 審査員

    Role(s)： Consultant

    Type： Research consultation

    2024.03

  • 茨城県高校生科学研究発表会 審査員

    Role(s)： Consultant

    Type： Other

    2022.03

  • シンセティック・セルバイオロジー -微生物や植物の遺伝子を薬にする-

    Role(s)： Lecturer

    Type： Science cafe

    バイオeカフェ@筑波大学  2022.01

  • 細胞運動制御におけるPCTK3シグナル伝達機構の解明

    Type： Citizen’s meeting/Assembly

    未来博士3分間コンペティション2015  2015.11

Media Coverage

  • 繊毛虫テトラヒメナのATG8ホモログであるTtATG8AおよびTtATG8Bは、飢餓によって誘導されるミトコンドリア分解に関与する Internet

    ユサコ株式会社  https://www.usaco.co.jp/article/detail.html?itemid=2478&dispmid=610