Updated on 2026/04/24

写真a

 
MUROTA KAEKO
 
Organization
Graduate School of Agriculture Department of Applied Biological Chemistry Professor
School of Agriculture Department of Applied Biological Chemistry
Title
Professor
Affiliation
Institute of Agriculture
Affiliation campus
Nakamozu Campus

Position

  • Graduate School of Agriculture Department of Applied Biological Chemistry 

    Professor  2026.04 - Now

  • School of Agriculture Department of Applied Biological Chemistry 

    Professor  2026.04 - Now

Degree

  • 博士（農学） （ Kyoto University ）

Research Areas

  • Life Science / Food sciences

  • Humanities & Social Sciences / Family and consumer sciences, and culture and living  / functional foods

Research Interests

  • 脂肪酸輸送担体

  • 脂肪酸

  • 脂溶性食品成分

  • 粘膜透過性

  • 消化管

  • 小腸

  • 吸収

  • 刷子縁膜輸送

  • リンパ

  • モノアシルグリセロール

  • プロビタミンA

  • フラボノイド

  • ビタミンE

  • ケルセチン

  • カイロミクロン

  • Lipid

  • Gastrointestinal Tract

  • Flavonoid

  • Caco-2

  • Absorption

  • Functional food factors, Bioavailability, Gastrointestinal tract, Dietary lipids, Polyphenols

  • 脂質

Professional Memberships

  • THE VITAMIN SOCIETY OF JAPAN

  • 日本農芸化学会

  • THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS

  • 日本栄養・食糧学会

  • 日本ポリフェノール学会

  • 日本フードファクター学会

▼display all

Awards

  • 農芸化学女性研究者賞

    室田 佳恵子

    2019.03   日本農芸化学会  

  • 平成20年度 日本栄養・食糧学会奨励賞

    2008.05  

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    Country：Japan

Papers

  • Functional evaluation of perilla leaf tea as a pancreatic lipase inhibitor: roles of rosmarinic acid and emulsion structure.

    Mohammad Ariful Islam Bhuiya, Keisuke Yoshikiyo, Yukine Moda, Pinky Karim Syeda K Fatima, Kaeko Murota

    Bioscience, biotechnology, and biochemistry   2026.01（ ISSN:0916-8451 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Obesity is a growing global concern, and pancreatic lipase inhibitors have emerged as potential targets for anti-obesity strategies. This study evaluates the potential of Perilla frutescens (L.) Britton var. frutescens leaf tea as a pancreatic lipase inhibitor for managing dietary fat absorption. Perilla leaf tea significantly inhibited the pancreatic lipase-mediated hydrolysis of emulsified triglycerides, depending on its polyphenol and rosmarinic acid contents. However, the inhibitory effect diminished at higher concentrations, which coincided with the increased emulsion particle size. Perilla leaf tea did not inhibit the hydrolysis of solubilized p-nitrophenyl palmitate, whereas authentic rosmarinic acid reduced lipase activity against both substrate types. These findings suggest that perilla leaf tea and rosmarinic acid have different lipase inhibition mechanisms. This study implies that rosmarinic acid contributes to the lipase-inhibiting properties of perilla leaf tea and emulsion structure plays a pivotal role in modulating the ability of the tea to inhibit lipase activity.

    DOI： 10.1093/bbb/zbag021

    PubMed

  • 【ポリフェノール研究の現状と展望】ポリフェノールの吸収と代謝-フラボノイド配糖体の親水性/疎水性と生体利用性

    室田 佳恵子

    Foods & Food Ingredients Journal of Japan   231 ( 1 )   16 - 23   2026.01（ ISSN:0919-9772 ）

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    ポリフェノールは複数のフェノール性水酸基を有する化合物の総称であるが、その化学構造は多種多様で8000種以上存在するといわれている。中でもフラボノイドは代表的で、主に配糖体やエステルとして存在し、酵素や腸内細菌により加水分解後に吸収されるが、一部は未変化のまま体内から検出される。ADME(吸収・分布・代謝・排泄)は、薬理学において薬効を変化させるステップとして十分な検証が必要とされ、機能性食品成分においても、その吸収性(体内濃度)、活性分子形態(代謝による構造変換)、標的臓器への蓄積性、排泄速度などを踏まえて作用機序を考える必要がある。本稿ではケルセチン配糖体を例に、構造や極性が生体利用性に及ぼす影響を整理し、吸収部位や代謝、吸収経路について、これまでの知見を以下の項目に分けて概説した。1)配糖体の構造と吸収部位。2)配糖体の極性と吸収性。3)エステル化合物の生体利用性。4)ポリフェノールの抱合代謝と吸収経路。

  • 【ミツバチ産品:プロポリスの健康機能研究と栄養・食糧学】ブラジル産グリーンプロポリス成分の吸収と代謝

    山家 雅之, 谷 央子, 室田 佳恵子

    日本栄養・食糧学会誌   77 ( 3 )   163 - 170   2024.06（ ISSN:0287-3516 ）

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    プロポリスはミツバチが作り出す養蜂産品のひとつで,高い抗菌,抗酸化作用を有しており,古くから民間療法として利用されてきた。ブラジル南東部で生産されるグリーンプロポリスはヒト試験において様々な有効性が報告されており,特徴的に含まれるアルテピリンCやドルパニンなどの経皮酸誘導体がその活性成分であると考えられているが,生体内への吸収や代謝に関する研究報告は多くない。私たちはこれまでに,ヒトおよびラットを用いてプロポリス成分の血中への吸収性や代謝物の解析を進め,プロポリス中でアルテピリンCよりも含有量の少ないドルパニンの方が高い血中濃度を示すことや,それらが抱合代謝を受けるだけでなく,酸化反応により水酸基が導入されることを明らかにしてきた。本総説では私たちが行ってきた研究の結果を中心に,プロポリス成分として経皮酸誘導体に焦点を当ててその吸収性と代謝性について概説するとともに,今後の展望について述べる。(著者抄録)

  • Efficient and safe extraction of an antioxidant, 3,5,4’-trihydroxy-6,7-methylenedioxyflavone-3-O-glycoside, from indigo leaves using alkaline hydrolysis of modifying ester moieties Reviewed

    Kimura Hideto, Ishihara Tomoe, Ishida Miki, Ishida Miki, Hirabayashi Yu, Jisaka Mitsuo, Jisaka Mitsuo, Murota Kaeko, Murota Kaeko

    Food Science and Technology Research   30 ( 3 )   313 - 321   2024.05（ ISSN:1344-6606 ）

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    Publishing type：Research paper (scientific journal)  

    J-GLOBAL

  • Co-ingestion with y-cyclodextrin improves bioavailability of a-linolenic acid in Perilla frutescens seed oil Reviewed

    Keisuke Yoshikiyo, Miho Takahashi, Yu Narumiya, Mikito Honda, Keita Iwasaki, Mika Ishigaki, Edward G. Nagato, Hemanth Noothalapati, Hidehisa Shimizu, Kaeko Murota, Tatsuyuki Yamamoto

    FOOD HYDROCOLLOIDS FOR HEALTH   3   2023.12（ ISSN:2667-0259 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.fhfh.2023.100116

  • The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection

    Masaya Goto, Shinya Yoshino, Kyona Hiroshima, Toru Kawakami, Kaeko Murota, Shigeru Shimamoto, Yuji Hidaka

    MOLECULES   28 ( 3 )   2023.02（ eISSN:1420-3049 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.3390/molecules28031128

    PubMed

  • Oleic acid stimulates cell proliferation and BRD4-L-MYC-dependent glucose transporter transcription through PPARa activation in ovarian cancer cells Reviewed

    Kaeko Murota

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   657 ( 21 )   24 - 34   2023（ ISSN:0006-291X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/J.BBRC.2023.03.051

    PubMed

  • Transport Form and Pathway from the Intestine to the Peripheral Tissues and the Intestinal Absorption and Metabolism Properties of Oleamide. Reviewed

    Yasuyuki Kobayashi, Natsumi Watanabe, Reina Hiura, Mai Kubota, Kousuke Furuta, Keiichiro Sugimoto, Kaeko Murota, Eri Nakamura, Toshiki Matsuura, Kenji Kai, Takashi Inui, Tomoya Kitakaze, Naoki Harada, Ryoichi Yamaji

    Journal of agricultural and food chemistry   70 ( 49 )   15499 - 15508   2022.12（ ISSN:0021-8561 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    This study aimed to obtain information on the transport form and pathway from the intestine to the peripheral tissues and on the intestinal absorption and metabolism properties of oleamide (cis-9-octadecenamide). Oleamide was primarily transported via the portal vein. Density gradient centrifugation indicated that plasma oleamide was enriched in the fractions containing albumin in the portal and peripheral blood. Oleamide formed a complex with albumin in an endothermic reaction (apparent Kd = 4.4 μM). The CD36 inhibitor inhibited the oleamide uptake into the intestinal epithelial Caco-2 cells, and oleamide decreased the cell surface CD36 level. The fatty acid amide hydrolase (FAAH) inhibitor increased the transepithelial transport of oleamide across Caco-2 cells and the plasma oleamide concentration in mice intragastrically administered with oleamide. These results indicate that oleamide is transported primarily via the portal vein as a complex with albumin. Furthermore, we suggest that oleamide is taken up via CD36 in the small intestine and degraded intracellularly by FAAH.

    DOI： 10.1021/acs.jafc.2c06791

    PubMed

  • Metabolic pathways of cinnamic acid derivatives in Brazilian green propolis in rats. Reviewed

    Masayuki Yamaga, Hiroko Tani, Kaeko Murota

    Bioscience, biotechnology, and biochemistry   86 ( 8 )   1075 - 1084   2022.07（ ISSN:0916-8451 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Cinnamic acid derivatives, which are dietary phenolic compounds, are attracting attention for their health benefits. Artepillin C, drupanin, baccharin, and p-coumaric acid are major cinnamic acid derivatives in Brazilian green propolis (BGP) used as functional food materials. To investigate the metabolism of these cinnamic acid derivatives, each compound was administered to rats, and their metabolic profiles were compared with those administered with BGP. Artepillin C is metabolized to hydroxylated metabolites (capillartemisin A), as well as glucuronide. Drupanin sulfate, glucuronide, and hydroxylated form were detected in plasma both after ingestion of drupanin and its 3-phenylpropionic acid ester (baccharin). p-Coumaric acid underwent sulfation, but not glucuronidation. These results reveal that the metabolic pathways of cinnamic acid derivatives in rats comprise ester hydrolysis and hydroxylation, as well as phase-II conjugation. Our findings may provide significant information for estimating the potential activity of various cinnamic acid derivatives derived from functional food materials.

    DOI： 10.1093/bbb/zbac076

    PubMed

  • Pharmacokinetics and metabolism of cinnamic acid derivatives and flavonoids after oral administration of Brazilian green propolis in humans. Reviewed

    Masayuki Yamaga, Hiroko Tani, Miyu Nishikawa, Keisuke Fukaya, Shin-Ichi Ikushiro, Kaeko Murota

    Food & function   12 ( 6 )   2520 - 2530   2021.03（ ISSN:2042-6496 ）

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    Authorship：Last author,　Corresponding author   Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Brazilian green propolis (BGP) has chemical compounds from botanical origin that are mainly cinnamic acid derivatives (artepillin C, baccharin, and drupanin) and flavonoids (kaempferide and 6-methoxykaempferide). These compounds are expected to play an important role in the pharmacological activities of BGP. However, there is little known about the pharmacokinetics and metabolism of these compounds after oral administration of BGP. The aim of this study is to investigate the pharmacokinetics and metabolism of BGP components in humans. Twelve volunteers received 3 capsules containing 360 mg of BGP ethanol extract powder. Plasma samples were collected before and up to 24 h after the intake of BGP capsules. The collected plasma samples with or without hydrolysis by the deconjugating enzyme were analyzed by LC/MS/MS. After enzymatic hydrolysis, the Cmax values of artepillin C and drupanin, which were detected mainly in plasma after ingestion of BGP capsules, were 1255 ± 517 and 2893 ± 711 nM, respectively, of which 89.3% and 88.2% were found to be the phenolic glucuronide conjugate. This is the first time that the pharmacokinetics of the BGP components of human metabolites have been reported. Our results could provide useful information for the design and interpretation of studies to investigate the mechanisms and pharmacological effects of BGP.

    DOI： 10.1039/d0fo02541k

    PubMed

  • Isolation of lactic acid bacteria capable of reducing environmental alkyl and fatty acid hydroperoxides, and the effect of their oral administration on oxidative-stressed nematodes and rats. Reviewed

    Akio Watanabe, Takuro Yamaguchi, Kaeko Murota, Naoaki Ishii, Junji Terao, Sanae Okada, Naoto Tanaka, Shinya Kimata, Akira Abe, Tomonori Suzuki, Masataka Uchino, Youichi Niimura

    PloS one   15 ( 2 )   e0215113   2020

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    Reinforcement of the hydroperoxide-eliminating activity in the small and large intestines should prevent associated diseases. We previously isolated a lactic acid bacterium, Pediococcus pentosaceus Be1 that facilitates a 2-electron reduction of hydrogen peroxide to water. In this study, we successfully isolated an alternative lactic acid bacterium, Lactobacillus plantarum P1-2, that can efficiently reduce environmental alkyl hydroperoxides and fatty acid hydroperoxides to their corresponding hydroxyl derivatives through a 2-electron reduction. Each strain exhibited a wide concentration range with regard to the environmental reducing activity for each hydroperoxide. Given this, the two lactic acid bacteria were orally administered to an oxygen-sensitive short-lived nematode mutant, and this resulted in a significant expansion of its lifespan. This observation suggests that P. pentosaceus Be1 and L. plantarum P1-2 inhibit internal oxidative stress. To determine the specific organs involved in this response, we performed a similar experiment in rats, involving induced lipid peroxidation by iron-overloading. We observed that only L. plantarum P1-2 inhibited colonic mucosa lipid peroxidation in rats with induced oxidative stress.

    DOI： 10.1371/journal.pone.0215113

    PubMed

  • Dynamics of the Cellular Metabolism of Leptosperin Found in Manuka Honey Reviewed

    Yoji Kato, Masaki Kawai, Shota Kawai, Yayako Okano, Natsumi Rokkaku, Akari Ishisaka, Kaeko Murota, Toshiyuki Nakamura, Yoshimasa Nakamura, Shinichi Ikushiro

    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY   67 ( 39 )   10853 - 10862   2019.10（ ISSN:0021-8561 ） （ eISSN:1520-5118 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1021/acs.jafc.9b03894

    PubMed

  • Roe-derived phospholipid administration enhances lymphatic docosahexaenoic acid-containing phospholipid absorption in unanesthetized rats Reviewed

    Kaeko Murota, Mika Takagi, Yomi Watanabe, Akira Tokumura, Takeshi Ohkubo

    PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS   139   40 - 48   2018.12（ ISSN:0952-3278 ） （ eISSN:1532-2823 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.plefa.2017.06.011

    PubMed

  • Inhibitory effect of catecholic colonic metabolites of rutin on fatty acid hydroperoxide and hemoglobin dependent lipid peroxidation in Caco-2 cells. Reviewed

    Agustin Martin Morales, Rie Mukai, Kaeko Murota, Junji Terao

    Journal of clinical biochemistry and nutrition   63 ( 3 )   175 - 180   2018.11（ ISSN:0912-0009 ） （ eISSN:1880-5086 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    DOI： 10.3164/jcbn.18-38

    PubMed

  • Lymphatic metabolites of quercetin after intestinal administration of quercetin-3-glucoside and its aglycone in rats. Reviewed

    Toshiyuki Nakamura, Chinatsu Kinjo, Yoshimasa Nakamura, Yoji Kato, Miyu Nishikawa, Masahiro Hamada, Noriyuki Nakajima, Shinichi Ikushiro, Kaeko Murota

    Archives of biochemistry and biophysics   645   126 - 136   2018.05（ ISSN:0003-9861 ） （ eISSN:1096-0384 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.abb.2018.03.024

    PubMed

  • Polyunsaturated fatty acids induce ovarian cancer cell death through ROS-dependent MAP kinase activation Reviewed

    Aiko Tanaka, Akane Yamamoto, Kaeko Murota, Toshifumi Tsujiuchi, Masao Iwamori, Nobuyuki Fukushima

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   493 ( 1 )   468 - 473   2017.11（ ISSN:0006-291X ） （ eISSN:1090-2104 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2017.08.168

    PubMed

  • Estimation of the Intestinal Absorption and Metabolism Behaviors of 2-and 3-Monochloropropanediol Esters Reviewed

    Naoki Kaze, Yomi Watanabe, Hirofumi Sato, Kaeko Murota, Miyako Kotaniguchi, Hiroshi Yamamoto, Hiroshi Inui, Shinichi Kitamura

    LIPIDS   51 ( 8 )   913 - 922   2016.08（ ISSN:0024-4201 ） （ eISSN:1558-9307 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11745-016-4143-z

    PubMed

  • Effect of Processed Onions on the Plasma Concentration of Quercetin in Rats and Humans. Reviewed

    Yasuaki Kashino, Kaeko Murota, Namiko Matsuda, Muneaki Tomotake, Takuya Hamano, Rie Mukai, Junji Terao

    Journal of food science   80 ( 11 )   H2597-602 - H2602   2015.11（ ISSN:0022-1147 ） （ eISSN:1750-3841 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1111/1750-3841.13079

    PubMed

  • Plasma metabolites of dietary flavonoids after combination meal consumption with onion and tofu in humans. Reviewed

    Toshiyuki Nakamura, Kaeko Murota, Shun Kumamoto, Kazuhiro Misumi, Noriko Bando, Shinichi Ikushiro, Nobuyuki Takahashi, Keiko Sekido, Yoji Kato, Junji Terao

    Molecular nutrition & food research   58 ( 2 )   310 - 7   2014.02（ ISSN:1613-4125 ） （ eISSN:1613-4133 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1002/mnfr.201300234

    PubMed

  • Extracellular metabolism-dependent uptake of lysolipids through cultured monolayer of differentiated Caco-2 cells Reviewed

    Maiko Inaba, Kaeko Murota, Miki Nikawadori, Erika Kishino, Risa Matusda, Mika Takagi, Takeshi Ohkubo, Tamotsu Tanaka, Junji Terao, Akira Tokumura

    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS   1841 ( 1 )   121 - 131   2014.01（ ISSN:1388-1981 ） （ eISSN:0006-3002 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbalip.2013.10.007

    PubMed

  • DHA attenuates postprandial hyperlipidemia via activating PPAR alpha in intestinal epithelial cells Reviewed

    Rino Kimura, Nobuyuki Takahashi, Shan Lin, Tsuyoshi Goto, Kaeko Murota, Rieko Nakata, Hiroyasu Inoue, Teruo Kawada

    JOURNAL OF LIPID RESEARCH   54 ( 12 )   3258 - 3268   2013.12（ ISSN:0022-2275 ） （ eISSN:1539-7262 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1194/jlr.M034942

    PubMed

  • Prenylation enhances quercetin uptake and reduces efflux in Caco-2 cells and enhances tissue accumulation in mice fed long-term. Reviewed

    Rie Mukai, Yutaka Fujikura, Kaeko Murota, Mariko Uehara, Shoko Minekawa, Naoko Matsui, Tomoyuki Kawamura, Hisao Nemoto, Junji Terao

    The Journal of nutrition   143 ( 10 )   1558 - 64   2013.10（ ISSN:0022-3166 ） （ eISSN:1541-6100 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.3945/jn.113.176818

    PubMed

  • Extracellular lipid metabolism influences the survival of ovarian cancer cells Reviewed

    Shohei Kuwata, Kei Ohkubo, Shun Kumamoto, Naoto Yamaguchi, Naoki Izuka, Kaeko Murota, Toshifumi Tsujiuchi, Masao Iwamori, Nobuyuki Fukushima

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   439 ( 2 )   280 - 284   2013.09（ ISSN:0006-291X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2013.08.041

    PubMed

  • Activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) in proximal intestine improves postprandial lipidemia in obese diabetic KK-Ay mice Reviewed

    Rino Kimura, Nobuyuki Takahashi, Tsuyoshi Goto, Kaeko Murota, Teruo Kawada

    OBESITY RESEARCH & CLINICAL PRACTICE   7 ( 5 )   E353 - E360   2013.09（ ISSN:1871-403X ） （ eISSN:1878-0318 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.orcp.2013.05.005

    PubMed

  • Liver Fatty Acid-binding Protein Binds Monoacylglycerol in Vitro and in Mouse Liver Cytosol Reviewed

    William S. Lagakos, Xudong Guan, Shiu-Ying Ho, Luciana Rodriguez Sawicki, Betina Corsico, Sarala Kodukula, Kaeko Murota, Ruth E. Stark, Judith Storch

    JOURNAL OF BIOLOGICAL CHEMISTRY   288 ( 27 )   19805 - 19815   2013.07（ ISSN:0021-9258 ） （ eISSN:1083-351X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1074/jbc.M113.473579

    PubMed

  • Influence of fatty acid patterns on the intestinal absorption pathway of quercetin in thoracic lymph duct-cannulated rats. Reviewed

    Kaeko Murota, Rainer Cermak, Junji Terao, Siegfried Wolffram

    The British journal of nutrition   109 ( 12 )   2147 - 53   2013.06（ ISSN:0007-1145 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1017/S0007114512004564

    PubMed

  • Plasma HDL Reduces Nonesterified Fatty Acid Hydroperoxides Originating from Oxidized LDL: a Mechanism for Its Antioxidant Ability Reviewed

    Mari Kotosai, Sachiko Shimada, Mai Kanda, Namiko Matsuda, Keiko Sekido, Yoshibumi Shimizu, Akira Tokumura, Toshiyuki Nakamura, Kaeko Murota, Yoshichika Kawai, Junji Terao

    LIPIDS   48 ( 6 )   569 - 578   2013.06（ ISSN:0024-4201 ） （ eISSN:1558-9307 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11745-013-3779-1

    PubMed

  • Asymmetric Dimethylarginine, an Endogenous NOS Inhibitor, Is Actively Metabolized in Rat Erythrocytes Reviewed

    Miyuki Yokoro, Makiko Suzuki, Kaeko Murota, Chie Otsuka, Hiromi Yamashita, Yoshitaka Takahashi, Hideaki Tsuji, Masumi Kimoto

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   76 ( 7 )   1334 - 1342   2012.07（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1271/bbb.120086

    PubMed

  • Bioavailability of orally administered water-dispersible hesperetin and its effect on peripheral vasodilatation in human subjects: implication of endothelial functions of plasma conjugated metabolites Reviewed

    Hiroko Takumi, Hiroyasu Nakamura, Terumi Simizu, Ryoko Harada, Takashi Kometani, Tomonori Nadamoto, Rie Mukai, Kaeko Murota, Yoshichika Kawai, Junji Terao

    FOOD & FUNCTION   3 ( 4 )   389 - 398   2012.04（ ISSN:2042-6496 ） （ eISSN:2042-650X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1039/c2fo10224b

    PubMed

  • Direct Absorption of Methyl Mercury by Lymph Reviewed

    Kaeko Murota, Mai Yoshida, Nana Ishibashi, Hideo Yamazaki, Takeshi Minami

    BIOLOGICAL TRACE ELEMENT RESEARCH   145 ( 3 )   349 - 354   2012.03（ ISSN:0163-4984 ） （ eISSN:1559-0720 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s12011-011-9190-y

    PubMed

  • Gastrointestinal Digestion and Absorption of Pen j 1, a Major Allergen from Kuruma Prawn, Penaeus japonicus Reviewed

    Ayumi Kunimoto, Miyuki Yokoro, Kaeko Murota, Rintaro Yamanishi, Toshiko Suzuki-Yamamoto, Makiko Suzuki, Chikao Yutani, Shinobu Doi, Miki Hiemori, Hiromi Yamashita, Yoshitaka Takahashi, Hideaki Tsuji, Masumi Kimoto

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   75 ( 7 )   1249 - 1258   2011.07（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1271/bbb.110021

    PubMed

  • Activation of peroxisome proliferator-activated receptor-alpha (PPAR alpha) suppresses postprandial lipidemia through fatty acid oxidation in enterocytes Reviewed

    Rino Kimura, Nobuyuki Takahashi, Kaeko Murota, Yuko Yamada, Saori Niiya, Noriyuki Kanzaki, Yoko Murakami, Tatsuya Moriyama, Tsuyoshi Goto, Teruo Kawada

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   410 ( 1 )   1 - 6   2011.06（ ISSN:0006-291X ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2011.05.057

    PubMed

  • alpha-Oligoglucosylation of a sugar moiety enhances the bioavailability of quercetin glucosides in humans. Reviewed

    Kaeko Murota, Namiko Matsuda, Yasuaki Kashino, Yutaka Fujikura, Toshiyuki Nakamura, Yoji Kato, Ryosuke Shimizu, Syuji Okuyama, Hisashi Tanaka, Takatoshi Koda, Keiko Sekido, Junji Terao

    Archives of biochemistry and biophysics   501 ( 1 )   91 - 7   2010.09（ ISSN:0003-9861 ） （ eISSN:1096-0384 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.abb.2010.06.036

    PubMed

  • Ingested quercetin but not rutin increases accumulation of hepatic beta-carotene in BALB/c mice. Reviewed

    Noriko Bando, Naomi Muraki, Kaeko Murota, Junji Terao, Rintaro Yamanishi

    Molecular nutrition & food research   54 Suppl 2   S261-7 - S267   2010.07（ ISSN:1613-4125 ） （ eISSN:1613-4133 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1002/mnfr.200900329

    PubMed

  • Different profiles of quercetin metabolites in rat plasma: comparison of two administration methods. Reviewed

    Yoshichika Kawai, Satomi Saito, Tomomi Nishikawa, Akari Ishisaka, Kaeko Murota, Junji Terao

    Bioscience, biotechnology, and biochemistry   73 ( 3 )   517 - 23   2009.03（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1271/bbb.80516

    PubMed

  • (-)-epicatechin gallate accumulates in foamy macrophages in human atherosclerotic aorta: Implication in the anti-atherosclerotic actions of tea catechins Reviewed

    Yoshichika Kawai, Hiroko Tanaka, Kaeko Murota, Michitaka Naito, Junji Terao

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS   374 ( 3 )   527 - 532   2008.09（ ISSN:0006-291X ） （ eISSN:1090-2104 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1016/j.bbrc.2008.07.086

    PubMed

  • Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. Reviewed

    Yoshichika Kawai, Tomomi Nishikawa, Yuko Shiba, Satomi Saito, Kaeko Murota, Noriyuki Shibata, Makio Kobayashi, Masaya Kanayama, Koji Uchida, Junji Terao

    The Journal of biological chemistry   283 ( 14 )   9424 - 34   2008.04（ ISSN:0021-9258 ） （ eISSN:1083-351X ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1074/jbc.M706571200

    PubMed

  • Chiisanoside is not absorbed but inhib its oil absorption in the small intestine of rodents Reviewed

    Kazurna Yoshizumi, Kaeko Murota, Shiro Watanabe, Hironori Tomi, Tomoko Tsuji, Junji Terao

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   72 ( 4 )   1126 - 1129   2008.04（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1271/bbb.70761

    PubMed

  • Vegetable flavonoids and cardiovascular disease.

    Terao J, Kawai Y, Murota K

    Asia Pacific journal of clinical nutrition   17 Suppl 1   291 - 3   2008（ ISSN:0964-7058 ）

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  • Antioxidant capacity of albumin-bound quercetin metabolites after onion consumption in humans. Reviewed

    Kaeko Murota, Azusa Hotta, Hikaru Ido, Yoshichika Kawai, Jae-Hak Moon, Keiko Sekido, Hiroki Hayashi, Takahiro Inakuma, Junji Terao

    The journal of medical investigation : JMI   54 ( 3-4 )   370 - 4   2007.08（ ISSN:1343-1420 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：Domestic journal  

    Quercetin is a major dietary flavonoid found in onions and other vegetables. It is known that dietary quercetin is metabolized in the intestinal mucosa and the liver and is present as its glucuronide/sulfate conjugates with or without methylation. Although quercetin is known to possess strong antioxidant activity, there are only limited reports on the antioxidant activity of its metabolites. In this study, the antioxidant capacity of quercetin metabolites under physiological conditions was investigated. After consumption of cooked onion, more than 80% of quercetin metabolites were localized in the human plasma fraction containing concentrated serum albumin. Other lipoprotein fractions contained only small amounts of quercetin metabolites. Addition of quercetin 3-O-beta-glucuronide to the lipoprotein-eliminated plasma fraction generated antioxidant activity against LDL oxidation in a dose-dependent manner. However, onion consumption failed to enhance the antioxidant activity of the lipoprotein-eliminated plasma fraction against LDL oxidation, probably because the amount of quercetin metabolites bound to albumin was less than the effective level in an ex vivo study. The physiological role of plasma albumin in retaining quercetin metabolites needs to be further clarified.

    DOI： 10.2152/jmi.54.370

    PubMed

  • Effects of quercetin and quercetin 3-glucuronide on the expression of bone sialoprotein gene. Reviewed

    Dong-Soon Kim, Hideki Takai, Masato Arai, Shouta Araki, Masaru Mezawa, Yoshichika Kawai, Kaeko Murota, Junji Terao, Yorimasa Ogata

    Journal of cellular biochemistry   101 ( 3 )   790 - 800   2007.06（ ISSN:0730-2312 ） （ eISSN:1097-4644 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1002/jcb.21233

    PubMed

  • Sodium cromoglycate inhibits absorption of the major soybean allergen, Gly m Bd 30K, in mice and human intestinal Caco-2 cells Reviewed

    Thanakorn Weangsripanaval, Kaeko Murota, Yoko Murakami, Masaru Kominami, Tatsuya Kusudo, Tatsuya Moriyama, Tadashi Ogawa, Teruo Kawada

    JOURNAL OF NUTRITION   136 ( 11 )   2874 - 2880   2006.11（ ISSN:0022-3166 ） （ eISSN:1541-6100 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jn/136.11.2874

    PubMed

  • Effect of dietary green tea catechin preparation on oxidative stress parameters in large intestinal mucosa of rats Reviewed

    M Yamamoto, S Miyamoto, JH Moon, K Murota, Y Hara, J Terao

    BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY   70 ( 1 )   286 - 289   2006.01（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1271/bbb.70.286

    PubMed

  • Quercetin appears in the lymph of unanesthetized rats as its phase II metabolites after administered into the stomach. Reviewed

    Kaeko Murota, Junji Terao

    FEBS letters   579 ( 24 )   5343 - 6   2005.10（ ISSN:0014-5793 ） （ eISSN:1873-3468 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1016/j.febslet.2005.08.060

    PubMed

  • Uptake of micellar long-chain fatty acid and sn-2-monoacylglycerol into human intestinal Caco-2 cells exhibits characteristics of protein-mediated transport Reviewed

    K Murota, J Storch

    JOURNAL OF NUTRITION   135 ( 7 )   1626 - 1630   2005.07（ ISSN:0022-3166 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1093/jn/135.7.1626

    PubMed

  • Quercetin-4'-glucoside is more potent than quercetin-3-glucoside in protection of rat intestinal mucosa homogenates against iron ion-induced lipid peroxidation. Reviewed

    Kaeko Murota, Yuki Mitsukuni, Mami Ichikawa, Tojiro Tsushida, Sayuri Miyamoto, Junji Terao

    Journal of agricultural and food chemistry   52 ( 7 )   1907 - 12   2004.04（ ISSN:0021-8561 ） （ eISSN:1520-5118 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1021/jf035151a

    PubMed

  • Phospholipid hydroperoxides are detoxified by phospholipase A(2) and GSH peroxidase in rat gastric mucosa Reviewed

    S Miyamoto, C Dupas, K Murota, J Terao

    LIPIDS   38 ( 6 )   641 - 649   2003.06（ ISSN:0024-4201 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11745-003-1109-6

    PubMed

  • Unique uptake and transport of isoflavone aglycones by human intestinal caco-2 cells: comparison of isoflavonoids and flavonoids. Reviewed

    Kaeko Murota, Sumie Shimizu, Sayuri Miyamoto, Toru Izumi, Akio Obata, Mamoru Kikuchi, Junji Terao

    The Journal of nutrition   132 ( 7 )   1956 - 61   2002.07（ ISSN:0022-3166 ） （ eISSN:1541-6100 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1093/jn/132.7.1956

    PubMed

  • Effect of quercetin and its conjugated metabolite on the hydrogen peroxide-induced intracellular production of reactive oxygen species in mouse fibroblasts. Reviewed

    Mutsuko Shirai, Rintaro Yamanishi, Jae-Hak Moon, Kaeko Murota, Junji Terao

    Bioscience, biotechnology, and biochemistry   66 ( 5 )   1015 - 21   2002.05（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    DOI： 10.1271/bbb.66.1015

    PubMed

  • Inhibitory effect of monoacylglycerol on fatty acid uptake into rat intestinal epithelial cells Reviewed

    Kaeko Murota, Noriko Matsui, Teruo Kawada, Nobuyuki Takahashi, Tohru Fushuki

    Bioscience, Biotechnology and Biochemistry   65 ( 6 )   1441 - 1443   2001.06（ ISSN:0916-8451 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1271/bbb.65.1441

    PubMed

  • [Plasma membrane fatty acid transporters].

    Murota K, Kawada T, Fushiki T

    Nihon rinsho. Japanese journal of clinical medicine   59 Suppl 2   240 - 4   2001.02（ ISSN:0047-1852 ）

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  • Influence of fatty alcohol and other fatty acid derivatives on fatty acid uptake into rat intestinal epithelial cells Reviewed

    K Murota, N Matsui, T Kawada, N Takahashi, T Shintani, K Sasaki, T Fushiki

    LIPIDS   36 ( 1 )   21 - 26   2001.01（ ISSN:0024-4201 ）

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    Publishing type：Research paper (scientific journal)  

    DOI： 10.1007/s11745-001-0663-2

    PubMed

  • Efficiency of absorption and metabolic conversion of quercetin and its glucosides in human intestinal cell line Caco-2. Reviewed

    K Murota, S Shimizu, H Chujo, J H Moon, J Terao

    Archives of biochemistry and biophysics   384 ( 2 )   391 - 7   2000.12（ ISSN:0003-9861 ）

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    Publishing type：Research paper (scientific journal)   International / domestic magazine：International journal  

    The efficiency of intestinal absorption and metabolic conversion of quercetin aglycone and its glucosides, quercetin-4'-O-beta-D-glucoside (Q4'G), quercetin-3-O-beta-D-glucoside (Q3G), and quercetin-3,4'-di-O-beta-D-glucoside (Q3,4'G), was estimated by using Caco-2 cell monolayers as an intestinal epithelial cell model. Aglycone was significantly lost from the apical side, resulting in the appearance of free and conjugated forms of quercetin and those of isorhamnetin in the cellular extracts. In the basolateral solution, the conjugated form of quercetin was predominant and increased with the elapse of incubation. As compared with quercetin aglycone, none of the quercetin glucosides were absorbed efficiently from apical side. However, Q4'G yielded conjugated quercetin and isorhamnetin in basolateral solution at higher amounts than Q3G or Q3,4'G. Lipophilicity of Q4'G was found to be higher than that of Q3G or Q3,4'G. This suggests that lipophilicity contributes to the relatively efficient absorption of Q4'G. It is likely that the occurrence of hydrolysis enhances the efficiency of intestinal absorption and metabolic conversion of dietary quercetin glucosides.

    DOI： 10.1006/abbi.2000.2123

    PubMed

  • Oleyl alcohol inhibits intestinal long-chain fatty acid absorption in rats Reviewed

    K Murota, T Kawada, N Matsui, M Sakakibara, N Takahashi, T Fushiki

    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY   46 ( 6 )   302 - 308   2000.12（ ISSN:0301-4800 ）

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    Publishing type：Research paper (scientific journal)  

  • Oleyl alcohol inhibits intestinal long-chain fatty acid absorption in rats.

    Murota K, Kawada T, Matsui N, Sakakibara M, Takahashi N, Fushiki T

    Journal of nutritional science and vitaminology   46 ( 6 )   302 - 8   2000.12（ ISSN:0301-4800 ）

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▼display all

Books and Other Publications

  • エッセンシャル食品化学

    中村 宜督, 榊原 啓之, 室田 佳恵子（ Role： Joint editor）

    講談社  2018.12 

MISC

  • 食事性ポリフェノールの生体利用性に影響する化学構造

    室田 佳恵子

    日本ポリフェノール学会雑誌   14   49 - 54   2025.06（ ISSN:2187-1175 ）

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    著者らはこれまで、フラボノイド配糖体の中でも特にケルセチンの配糖体に着目した生体利用性研究を行ってきた。フラボノイド配糖体を食品成分として摂取した場合、そのままの形で吸収される割合は低く、多くは加水分解で生じたアグリコンやその異化代謝物となって吸収される。そのため、フラボノイドの体内での機能性について明らかにするためには、フラボノイドの消化管内での消化・腸内細菌代謝動態を把握することが重要である。今回、ポリフェノールの消化吸収代謝について、化学構造という視点から、著者らの研究成果を含めこれまでの知見を以下の項目に分けて概説した。1)フラボノイド配糖体の消化吸収代謝。2)モノグルコシド配糖体の極性と吸収性。3)エステル体ポリフェノールの消化吸収代謝。4)ポリフェノールのリンパ系輸送経路と化学構造の関係。

  • Absorption and Metabolism of Components in Brazilian Green Propolis Invited Reviewed

    Masayuki Yamaga, Hiroko Tani, Kaeko Murota

    Nippon Eiyo Shokuryo Gakkaishi   77 ( 3 )   163 - 170   2024.06（ ISSN:0287-3516 ） （ eISSN:1883-2849 ）

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    Authorship：Corresponding author   Publishing type：Article, review, commentary, editorial, etc. (scientific journal)  

    DOI： 10.4327/jsnfs.77.163

  • リン脂質におけるDHAの結合位置の違いが消化吸収特性へ与える影響

    茂田幸音, 山浦凛子, 渡辺嘉, 室田佳恵子, 室田佳恵子

    脂質生化学研究   66   2024（ ISSN:0285-1520 ）

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  • DHA結合型リン脂質の膵酵素および腸管粘膜酵素による消化性の解析

    茂田幸音, 山浦凛子, 渡辺嘉, 室田佳恵子, 室田佳恵子

    日本栄養・食糧学会大会講演要旨集   78th   2024

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  • Potentials of agricultural wastes of ‘Shinku,’ a new red grapes cultivar in Shimane Prefecture utilizing in skin care cosmetics

    室田佳恵子, SHAHIDUR Rahman Mohammad, 多田明弘, 宮崎博隆

    島根大学生物資源科学部研究報告(Web)   ( 28 )   2024（ ISSN:2435-0885 ）

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  • リン脂質結合型DHAの消化吸収性に対する脂肪酸結合位置の影響

    茂田幸音, 山浦凛子, 渡辺嘉, 室田佳恵子, 室田佳恵子

    日本栄養・食糧学会大会講演要旨集   77th   2023

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  • 海外におけるポリフェノールデータベースの紹介と日本における現状ポリフェノールデータベースの課題と今後： Reviewed

    室田 佳恵子, Claudine Manach, Christine Morand, 下位 香代子

    化学と生物   59 ( 9 )   464 - 472   2021.09

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    Authorship：Lead author  

  • Variety of the world propolis and approach to the quality standard based on efficacy of propolis.

    山家雅之, 山家雅之, 谷央子, 室田佳恵子, 室田佳恵子

    日本ポリフェノール学会雑誌   10   2021（ ISSN:2187-1175 ）

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  • Absorption pathway of dietary flavonoids: the potential roles of the lymphatic transport in the intestine Reviewed

    Kaeko Murota

    FUNCTIONAL FOODS IN HEALTH AND DISEASE   10 ( 7 )   274 - 289   2020.07（ ISSN:2160-3855 ）

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    Publishing type：Book review, literature introduction, etc.  

    DOI： 10.31989/ffhd.v10i7.723

  • Digestion and absorption of dietary glycerophospholipids in the small intestine: Their significance as carrier molecules of choline and n-3 polyunsaturated fatty acids Invited Reviewed

    Kaeko Murota

    BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY   26   101633 - 101633   2020.07（ ISSN:1878-8181 ） （ eISSN:1878-8181 ）

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    Publishing type：Book review, literature introduction, etc.  

    DOI： 10.1016/J.BCAB.2020.101633

  • Bioavailability of Dietary Flavonoids: The Structural Changes by Various Metabolisms and the Physiological Functions-Absorption and Metabolism of Dietary Flavonoids are Involved in Their Physiological Functions

    室田佳恵子

    化学と生物   58 ( 5 )   2020（ ISSN:0453-073X ）

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  • Recent Trend and Future Directions of Research on Polyphenols and Health

    下位香代子, 室田佳恵子

    Foods & Food Ingredients Journal of Japan   225 ( 2 )   2020（ ISSN:0919-9772 ）

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  • Absorption, metabolism and distribution of dietary flavonoids

    室田佳恵子, 室田佳恵子

    ビタミン   93 ( 9 )   2019（ ISSN:0006-386X ）

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  • ファイトケミカルの生体利用性と機能性発現調節

    室田佳恵子

    ビタミン   93 ( 4 )   2019（ ISSN:0006-386X ）

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  • Flavonoid metabolism: the interaction of metabolites and gut microbiota. Reviewed International journal

    Kaeko Murota, Yoshimasa Nakamura, Mariko Uehara

    Bioscience, biotechnology, and biochemistry   82 ( 4 )   600 - 610   2018.04（ ISSN:0916-8451 ） （ eISSN:1347-6947 ）

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    Publishing type：Book review, literature introduction, etc.   International / domestic magazine：International journal  

    DOI： 10.1080/09168451.2018.1444467

    PubMed

  • 脂溶性食品成分の腸管吸収機構と生体利用性

    室田佳恵子

    オレオサイエンス   18 ( 8 )   2018（ ISSN:1345-8949 ）

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  • 注目の食品機能性成分~その分析から生理作用の解明まで 食事性フラボノイドの多様な構造と生体利用性

    室田佳恵子

    機能性食品と薬理栄養   11 ( 2 )   2017（ ISSN:1348-2564 ）

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  • レプトスペリンおよびメチルシリンゲートの吸収代謝機構の解析

    加藤陽二, 石坂朱里, 竹内美栄, 荒木裕佳子, 河合慶親, 北元憲利, 室田佳恵子, 石川大仁, 榊利之, 生城真一

    日本フードファクター学会学術集会講演要旨集   21st   2016

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  • 異物代謝酵素発現酵母を用いたエクオール抱合代謝解析

    IKUSHIRO SHIN'ICHI, KATAOKA MAI, NISHIKAWA MIYU, YASUDA KAORI, MUROTA KAEKO, UEHARA MARIKO, KAMAKURA MASAKI, SAKAKI TOSHIYUKI

    ビタミン   88 ( 4 )   263 - 263   2014.04（ ISSN:0006-386X ）

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  • Effect of fats on direct absorption of methyl mercury by lymph

    MINAMI Takeshi, MATSUNO Takamasa, UKIBE Daiki, TAKAGI Mika, YAMAZAKI Hideo, MUROTA Kaeko

    Annual Meeting of the Japanese Society of Toxicology   39   AP - 43   2012

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    Methyl mercury is contained in fish and seafood products and is taken up into the body in food. The aim of the present study is to observe the effect of fats such as olive oil, lard, soybean oil and oleic acid on the lymphatic absorption of methyl mercury. Conscious rats were infused with methyl mercury including in fat via duodenal tubing, and lymphatic fluids were continuously collected from the thoracic lymph duct every 30 minutes until 360 minutes after infusion. When methyl mercury was infused with lard, total mercury contents in lymph gradually increased until 120-150 min.; however, when methyl mercury with soybean oil, olive oil, or oleic acid was infused, mercury contents in lymph peaked at 30-60 min. Furthermore, the cumulative mercury concentration in lymph during 360 min was the lowest in olive oil group and was soybean oil group next. The cumulative mercury concentrations in both lard and oleic acid groups were about the same. Blood mercury concentrations in both olive oil and oleic acid groups increased gradually until 240 min, and then showed about 2-fold at 270 min compared with 240 min. Blood mercury concentrations in both soybean oil and lard groups showed about half values of both olive oil and oleic acid groups. It is concluded that the lymphatic absorption of methyl mercury varies according to the composition of fats. In addition, it is thought that the absorption of methyl mercury to blood does not relate to the absorption to lymph.

    DOI： 10.14869/toxpt.39.2.0.AP-43.0

    CiNii Research

  • Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo. Reviewed International journal

    Junji Terao, Kaeko Murota, Yoshichika Kawai

    Food & function   2 ( 1 )   11 - 7   2011.01（ ISSN:2042-6496 ） （ eISSN:2042-650X ）

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    Publishing type：Book review, literature introduction, etc.   International / domestic magazine：International journal  

    DOI： 10.1039/c0fo00106f

    PubMed

  • 食後高脂血症抑制につながる腸管組織での脂質代謝制御機構に関する研究

    新谷紗織, 木村梨乃, 高橋信之, 室田佳恵子, 山田優子, 神崎範之, 村上陽子, 森山達也, 後藤剛, 河田照雄

    肥満研究   17 ( Supplement )   2011（ ISSN:1343-229X ）

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  • 小腸上皮組織におけるPPARα活性化を介した食後高脂血症の抑制

    新谷紗織, 高橋信之, 木村梨乃, 室田佳恵子, 山田優子, 森山達哉, 後藤剛, 河田照雄

    日本栄養・食糧学会近畿支部大会講演要旨集   50th   2011

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  • 赤血球における非対称性アルギニンメチル化タンパク質の産生と分解

    横路 三有紀, 鈴木 麻希子, 室田 佳恵子, 高橋 吉孝, 山下 広美, 比江森 美樹, 辻 英明, 木本 眞順美

    日本栄養・食糧学会大会講演要旨集   64回   175 - 175   2010.05

  • Transport Mechanism of Dietary Flavonoids and their Metabolites

    Murota Kaeko, Kawai Yoshichika, Terao Junji

    VITAMINS   84 ( 12 )   589 - 598   2010（ ISSN:0006-386X ）

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    Flavonoids are present in various plant foods such as vegetables, fruits and beverages. Flavonoids are known as powerful antioxidants and have attracted much attention to their potential role in the prevention of various diseases. In plant foods, most flavonoids exist as glycosides and/or acidic forms, and the type of a sugar moiety is a major determinant of the intestinal absorption. In the gastrointestinal tract, dietary flavonoids are mainly absorbed as their aglycone forms by simple diffusion, whereas there are some kind of membrane transporters that may work for cellular influx of certain flavonoids. The predominant circulating molecules after an oral consumption are conjugative metabolites because flavonoids undergo extensive intestinal and hepatic glucuronidation and sulfation. ABC transporters have been shown to serve for the cellular efflux of flavonoid metabolites. This review will summarize the current literatures regarding on the transport mechanism of dietary flavonoids and their conjugative metabolites.

    DOI： 10.20632/vso.84.12_589

    CiNii Research

    Other URL： http://search.jamas.or.jp/link/ui/2011087011

  • Antiatherosclerotic Effects of Dietary Flavonoids: Insight into their Molecular Action Mechanism at the Target Site Reviewed

    Junji Terao, Kaeko Murota, Yoshichika Kawai

    RECENT ADVANCES IN POLYPHENOL RESEARCH, VOL 2   2   299 - 318   2010

  • ケルセチンへの糖鎖修飾がヒトにおける吸収代謝に与える影響

    藤倉温, 松田奈美子, 中村俊之, 加藤陽二, 清水亮輔, 奥山秀二, 田中久志, 關戸啓子, 寺尾純二, 室田佳恵子

    日本栄養・食糧学会大会講演要旨集   64th   2010

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  • Integrated Study of the Intestinal Absorption and Bioavailability of Dietary Lipids and Lipophilic Food Components

    室田佳恵子

    日本栄養・食糧学会誌   62 ( 3 )   2009（ ISSN:0287-3516 ）

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  • GASTROINTESTINAL DIGESTION AND ABSORBABILITY OF TROPOMYOSIN, A MAJOR ALLERGEN IN SHRIMP

    Ayumil Kunimoto, Kaeko Murota, Shinobu Doi, Chikao Yutani, Makiko Suzuki, Miki Hiemori, Hiromi Yamashita, Hideaki Tsuji, Masumi Kimoto

    ANNALS OF NUTRITION AND METABOLISM   55   267 - 267   2009（ ISSN:0250-6807 ）

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    Publishing type：Research paper, summary (international conference)  

  • α-トコフェロールの腸管吸収における脂質分解酵素の重要性

    室田 佳恵子, 村上 陽子, 伊佐治 知也, 大久保 剛, 松村 康生, 板東 紀子, 寺尾 純二, 河田 照雄

    脂質生化学研究   50   42 - 43   2008.06（ ISSN:0285-1520 ）

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  • Vegetable flavonoids and cardiovascular disease. Reviewed International journal

    Junji Terao, Yoshichika Kawai, Kaeko Murota

    Asia Pacific journal of clinical nutrition   17 Suppl 1   291 - 3   2008（ ISSN:0964-7058 ）

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  • Bioavailability and Antioxidative Activity of Flavonoids from Vegetables

    Azuma Keiko, Murota Kaeko, Terao Junji

    VITAMINS   80 ( 8 )   403 - 410   2006（ ISSN:0006-386X ）

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    Vegetables contain a variety of flavonoids, such as flavonols, flavones and anthocyanidins. Numerous in vitro studies have revealed diverse biochemical actions of flavonoids, and their antioxidant activity should be, at least partly, responsible for these actions. We are interested in quercetin (3, 3', 4', 5, 7-pentahydroxyflavone), a flavonol-type flavonoid as an anti-atherosclerotic food factor and have examined its bioavailability to evaluate the biological effect. Quercetin and other flavonoids frequently exist as their glycoside forms in vegetables. Glucoside-bound quercetin is absorbed and hydrolyzed in small intestine through glucose-transport system or passive transport after lactase phlorizin hydrolase (LPH)-dependent deglucosidation. Quercetin glycosides other than glucoside forms are likely to be absorbed in large intestine after hydrolysis with enterobacteria. Efficiency of the absorption is considerably affected by the coexisting food components. Lipids and emulsifiers were found to enhance the absorption. In any cases, resulting quercetin aglycone is converted to conjugated glucuronides and/or sulfates during the process of their absorption. Some metabolites circulating in the blood stream can act as free radical scavengers, as well as the inhibitors of lipoxygenase and xanthine oxidase. It is therefore likely that biological effect of quercetin is originated from conjugated metabolites. Metabolic conversion of flavonoids to their conjugates may be a process for regulating their action on cellular oxidative stress.

    DOI： 10.20632/vso.80.8_403

    CiNii Research

    Other URL： http://search.jamas.or.jp/link/ui/2006322122

  • Intestinal absorption and metabolism ofauercetin and its distribution in circulatory system.

    K Murota, A Hotta, JH Moon, J Terao

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   229   U57 - U57   2005.03（ ISSN:0065-7727 ）

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    Publishing type：Research paper, summary (international conference)  

  • Antioxidative flavonoid quercetin: implication of its intestinal absorption and metabolism. Reviewed International journal

    Kaeko Murota, Junji Terao

    Archives of biochemistry and biophysics   417 ( 1 )   12 - 7   2003.09（ ISSN:0003-9861 ） （ eISSN:1096-0384 ）

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    Publishing type：Book review, literature introduction, etc.   International / domestic magazine：International journal  

    DOI： 10.1016/S0003-9861(03)00284-4

    PubMed

  • Protective effect of quercetin aglycone and its glucosides on iron ion-induced lipid peroxidation in rat gastrointestinal mucosa homogenate.

    J Terao, Y Mitsukuni, M Ichikawa, S Miyamoto, K Murota

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   226   U56 - U56   2003.09（ ISSN:0065-7727 ）

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    Publishing type：Research paper, summary (international conference)  

  • 4. 小腸吸収モデル培養細胞におけるフラボノイド・イソフラボノイドの吸収代謝と構造相関

    寺尾 純二, 清水 寿美恵, 室田 佳恵子

    ビタミン   76 ( 9 )   437 - 437   2002.09（ ISSN:0006-386X ）

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  • Antioxidant effect of a conjugated quercetin metabolite on cultured cells Reviewed

    J Terao, M Shirai, JH Moon, K Murota, R Yamanishi

    XI BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL   633 - 636   2002

  • Antioxidant effect of a conjugated quercetin metabolite on liposomal membranes and cultured cells

    J Terao, M Shirai, JH Moon, K Murota, R Yamanishi

    FREE RADICAL BIOLOGY AND MEDICINE   33   S210 - S210   2002（ ISSN:0891-5849 ）

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    Publishing type：Research paper, summary (international conference)  

  • フラボノイド配糖体は消化管でそのまま吸収されるか? 小腸粘膜での加水分解が吸収を促進する可能性

    室田 佳恵子, 寺尾 純二

    化学と生物   39 ( 4 )   213 - 215   2001.04（ ISSN:0453-073X ）

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  • 2-I-7 ケルセチン代謝物(Quercetin 3-O-β-glucuronide)の線維芽細胞への移行と抗酸化活性

    白井 睦子, 山西 倫太郎, 室田 佳恵子, 寺尾 純二

    ビタミン   75 ( 4 )   222 - 222   2001.04（ ISSN:0006-386X ）

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  • Absorption and metabolic conversion of quercetin and its glucosides in Caco-2 cells.

    K Murota, S Shimizu, JH Moon, J Terao

    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY   221   U20 - U20   2001.04（ ISSN:0065-7727 ）

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    Publishing type：Research paper, summary (international conference)  

  • 5. オレイルアルコールはラットにおいて小腸での長鎖脂肪酸の吸収を阻害する

    室田 佳恵子, 河田 照雄, 松井 紀子, 榊原 通宏, 高橋 信之, 伏木 亨

    ビタミン   75 ( 2 )   102 - 103   2001.02（ ISSN:0006-386X ）

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  • 膜局在性脂肪酸トランスポーター蛋白(共著)

    室田佳恵子, 河田照雄, 伏木亨

    日本臨牀   59 ( 増刊2 )   240 - 244   2001

  • The Measurement of ^<45>Ca Using "Ready Cap" Solid Scintillator Developed for Utilization in the Liquid Scintillation Counter

    MUROTA Kaeko, HITOMI Yoshitaka, KAWADA Teruo, FUSHIKI Tohru, KITAJIMA Sakihito, KATO Takahisa

    Radioisotopes   47 ( 3 )   216 - 221   1998.03（ ISSN:0033-8303 ）

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Presentations

Grant-in-Aid for Scientific Research

  • Elucidation of the molecular mechanism govering flavonoid biosynthesis using transient expression systems in edible plants

    Grant-in-Aid for Scientific Research(C)  2027

  • グリセロホスホコリン－吸収機構の解明から安全なコリン供給体として－

    Grant-in-Aid for Scientific Research(B)  2027

  • Elucidation of the molecular mechanism govering flavonoid biosynthesis using transient expression systems in edible plants

    Grant-in-Aid for Scientific Research(C)  2026

  • グリセロホスホコリン－吸収機構の解明から安全なコリン供給体として－

    Grant-in-Aid for Scientific Research(B)  2026

Charge of off-campus class subject

  • 食品衛生学

  • 食品生化学

    Institution：Shimane University

  • 食品機能学

    Institution：Shimane University

  • 食品化学

  • 栄養学