Updated on 2026/05/14

写真a

 
ANDO MITSURU
 
Organization
Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology Lecturer
School of Engineering Department of Applied Chemistry
Title
Lecturer
Affiliation
Institute of Engineering

Position

  • Graduate School of Engineering Division of Science and Engineering for Materials, Chemistry and Biology 

    Lecturer  2026.04 - Now

  • School of Engineering Department of Applied Chemistry 

    Lecturer  2026.04 - Now

Degree

  • 博士(薬学) ( Kyoto University )

Job Career (off-campus)

  • Institute for Life and Medical Sciences, Kyoto University   Lab. of Aging and Infection Control, Dept. of Biosystems Science   Adjunct Researcher

    2026.04 - Now

  • Institute for Life and Medical Sciences, Kyoto University   Department of Regeneration Science and Engineering

    2022.04 - 2026.03

  • Institute for Frontier Life and Medical Sciences, Kyoto University   Department of Regeneration Science and Engineering

    2021.05 - 2022.03

  • Institute for Frontier Life and Medical Sciences, Kyoto University   Department of Regeneration Science and Engineering   Research assistant

    2021.04

  • Okinawa Institute of Science and Technology Graduate University   Imaging Section   CryoEM trainee

    2021.02

  • Okinawa Institute of Science and Technology Graduate University   Imaging Section   CryoEM trainee

    2020.01

  • JST-CREST [Extracellular Fine Particles]   CREST-postdoctoral researcher

    2018.04 - 2020.03

  • Japan Science and Technology Agency

    2017.04 - 2018.03

  • Kyoto University   Graduate School of Engineering

    2014.04 - 2021.03

  • Japan Science and Technology Agency

    2014.04 - 2018.03

  • 日本学術振興会   特別研究員(PD)

    2013.04 - 2014.03

  • 日本学術振興会   特別研究員(DC2)

    2012.04 - 2013.03

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Papers

  • Preparation of Platelet Membrane‐Coated Gelatin Nanoparticle Toward Alternative to Platelet Preparation

    Mitsuru Ando, Keisuke Moriyama, Isamu Akiba, Yasuhiko Tabata

    Macromolecular Rapid Communications   2026.02( ISSN:1022-1336 ( eISSN:1521-3927

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    Authorship:Lead author, Corresponding author   Publishing type:Research paper (scientific journal)  

    ABSTRACT

    Platelets play a critical role in hemostasis and tissue repair; however, their short shelf life of approximately four days poses a major challenge to their supply. This limitation underscores the need for long‐term storage alternatives. In this study, we developed and characterized platelet membrane–coated gelatin nanoparticles (PL‐GNPs) as potential platelet substitutes. PL‐GNPs were prepared by coating gelatin nanoparticles (GNPs) with platelet‐derived membrane vesicles. Cryo‐electron microscopy revealed the formation of a core–shell structure, and immunoblotting demonstrated that key platelet surface proteins, CD41 and CD61, were preserved on the PL‐GNP surface in the same orientation as in platelets. The membrane coating improved the stability of the nanoparticles against collagenase‐dependent degradation. Moreover, PL‐GNPs bound effectively to fibrinogen, an essential interaction in thrombus formation, and retained this function even after one month of storage at 4°C. Collectively, these findings indicate that PL‐GNPs recapitulate the critical structural and functional properties of native platelets and hold promise as a stable, long‐term storable alternative to conventional platelet preparations for therapeutic use.

    DOI: 10.1002/marc.202500826

    Other URL: https://onlinelibrary.wiley.com/doi/full-xml/10.1002/marc.202500826

  • Poly(2‐Propyl‐2‐Oxazoline)‐Induced Lipid Nanotube Formation in Phospholipid Multilayers

    Ryosuke Mizuta, Tatsuhiko Murata, Mitsuru Ando, Tomoki Nishimura, Shin‐ichi Sawada, Kazunari Akiyoshi, Yoshihiro Sasaki

    Macromolecular Rapid Communications   2025.11

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/marc.202500702

  • Mesenchymal Stem Cell Membrane Coating of Gelatin Nanospheres with Drug Release Ability for Inflammatory Tissue Targeting

    Keisuke Moriyama, Mitsuru Ando, Kazuo Sakurai, Isamu Sakurai, Yasuhiko Tabata

    bioRxiv   2025.06

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    Authorship:Corresponding author  

    DOI: 10.1101/2025.06.01.657318

  • Association with Cationized Gelatin Nanospheres Enhances Mitochondria Uptake and Membrane Potential.

    Wenxuan Yang, Satoshi Abe, Mitsuru Ando, Yasuhiko Tabata

    Tissue engineering. Part A   2024.12

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    The objective of this study is to investigate the influence of exogenous mitochondria (Mt) internalization on the Mt membrane potential of cells. Cationized gelatin nanospheres (cGNS) were prepared to mix Mt at different ratios to prepare Mt associated with cGNS (Mt-cGNS). The Mt internalization depended on the Mt/cGNS mixing ratio to achieve the maximum at the ratio of 3/1. Rho 0 cells of a Mt function-deficient line were prepared to evaluate the enhancement of Mt membrane potential of rho 0 cells after the internalization of Mt-cGNS. When evaluated by using tetramethylrhodamine methyl ester reagent, the mitochondrial membrane potential of rho 0 cells after incubation with Mt-cGNS enhanced compared with that incubated with Mt only and maintained at a significantly higher level even for 6 days. The Mt-cGNS were internalized into rho 0 cells by an actin-dependent pathway, followed by fused with endogenous Mt. It is concluded that association with the cGNS enabled Mt to enhance the cellular internalization, followed by the fusion with endogenous Mt to maintain an enhanced Mt membrane potential.

    DOI: 10.1089/ten.tea.2024.0265

    PubMed

  • Distribution and Incorporation of Extracellular Vesicles into Chondrocytes and Synoviocytes.

    Takashi Ohtsuki, Ikumi Sato, Ren Takashita, Shintaro Kodama, Kentaro Ikemura, Gabriel Opoku, Shogo Watanabe, Takayuki Furumatsu, Hiroshi Yamada, Mitsuru Ando, Kazunari Akiyoshi, Keiichiro Nishida, Satoshi Hirohata

    International journal of molecular sciences   25 ( 22 )   2024.11

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Osteoarthritis (OA) is a chronic disease affecting over 500 million people worldwide. As the population ages and obesity rates rise, the societal burden of OA is increasing. Pro-inflammatory cytokines, particularly interleukin-1β, are implicated in the pathogenesis of OA. Recent studies suggest that crosstalk between cartilage and synovium contributes to OA development, but the mechanisms remain unclear. Extracellular vesicles (EVs) were purified from cell culture-conditioned medium via ultracentrifugation and confirmed using transmission electron microscopy, nanoparticle tracking analysis, and western blotting. We demonstrated that EVs were taken up by human synoviocytes and chondrocytes in vitro, while in vivo experiments revealed that fluorescent-labelled EVs injected into mouse joints were incorporated into chondrocytes and synoviocytes. EV uptake was significantly inhibited by dynamin-mediated endocytosis inhibitors, indicating that endocytosis plays a major role in this process. Additionally, co-culture experiments with HEK-293 cells expressing red fluorescent protein (RFP)-tagged CD9 and the chondrocytic cell line OUMS-27 confirmed the transfer of RFP-positive EVs across a 600-nm but not a 30-nm filter. These findings suggest that EVs from chondrocytes are released into joint fluid and taken up by cells within the cartilage, potentially facilitating communication between cartilage and synovium. The results underscore the importance of EVs in OA pathophysiology.

    DOI: 10.3390/ijms252211942

    PubMed

  • Manipulation of Macrophage Uptake by Controlling the Aspect Ratio of Graft Copolymer Micelles. Reviewed

    Yusuke Sakamoto, Shota Fujii, Shin Takano, Jokichi Fukushima, Mitsuru Ando, Noriyuki Kodera, Tomoki Nishimura

    Nano letters   24 ( 19 )   5838 - 5846   2024.05

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Nanostructures of drug carriers play a crucial role in nanomedicine due to their ability to influence drug delivery. There is yet no clear consensus regarding the optimal size and shape (e.g., aspect ratio) of nanoparticles for minimizing macrophage uptake, given the difficulties in controlling the shape and size of nanoparticles while maintaining identical surface properties. Here, we employed graft copolymer self-assembly to prepare polymer micelles with aspect ratios ranging from 1.0 (spherical) to 10.8 (cylindrical) and closely matched interfacial properties. Notably, our findings emphasize that cylindrical micelles with an aspect ratio of 2.4 are the least susceptible to macrophage uptake compared with both their longer counterparts and spherical micelles. This reduced uptake of the short cylindrical micelles results in a 3.3-fold increase in blood circulation time compared with their spherical counterparts. Controlling the aspect ratio of nanoparticles is crucial for improving drug delivery efficacy through better nanoparticle design.

    DOI: 10.1021/acs.nanolett.4c01054

    PubMed

  • A Simple Preparation Method of Gelatin Hydrogels Incorporating Cisplatin for Sustained Release. Reviewed

    Takahisa Suzuki, Shigeru Tsunoda, Kota Yamashita, Toshie Kuwahara, Mitsuru Ando, Yasuhiko Tabata, Kazutaka Obama

    Pharmaceutics   14 ( 12 )   2022.11

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    The objective of this study was to develop a new preparation method for cisplatin (CDDP)-incorporated gelatin hydrogels without using chemical crosslinking nor a vacuum heating instrument for dehydrothermal crosslinking. By simply mixing CDDP and gelatin, CDDP-crosslinked gelatin hydrogels (CCGH) were prepared. CDDP functions as a crosslinking agent of gelatin to form the gelatin hydrogel. Simultaneously, CDDP is incorporated into the gelatin hydrogel as a controlled release carrier. CDDP's in vitro and in vivo anticancer efficacy after incorporation into CCGH was evaluated. In the in vitro system, the CDDP was released gradually due to CCGH degradation with an initial burst release of approximately 16%. CDDP metal-coordinated with the degraded fragment of gelatin was released from CCGH with maintaining the anticancer activity. After intraperitoneal administration of CCGH, CDDP was detected in the blood circulation while its toxicity was low. Following intraperitoneal administration of CCGH in a murine peritoneal dissemination model of human gastric cancer MKN45-Luc cell line, the survival time was significantly prolonged compared with free CDDP solution. It is concluded that CCGH prepared by the CDDP-based crosslinking of gelatin is an excellent sustained release system of CDDP to achieve superior anticancer effects with minimal side effects compared with free CDDP solution.

    DOI: 10.3390/pharmaceutics14122601

    PubMed

  • Single-component nanodiscs via the thermal folding of amphiphilic graft copolymers with the adjusted flexibility of the main chain. Reviewed

    Tomoki Nishimura, Yusuke Hatatani, Mitsuru Ando, Yoshihiro Sasaki, Kazunari Akiyoshi

    Chemical science   13 ( 18 )   5243 - 5251   2022.05

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    Publishing type:Research paper (scientific journal)   International / domestic magazine:International journal  

    Nanodiscs have attracted considerable attention as structural scaffolds for membrane-protein research and as biomaterials in e.g. drug-delivery systems. However, conventional disc-fabrication methods are usually laborious, and disc fabrication via the self-assembly of amphiphiles is difficult. Herein, we report the formation of polymer nanodiscs based on the self-assembly of amphiphilic graft copolymers by adjusting the persistence length of the main chain. Amphiphilic graft copolymers with a series of different main-chain persistence lengths were prepared and these formed, depending on the persistence length, either rods, discs, or vesicles. Notably, polymer nanodiscs were formed upon heating a chilled polymer solution without the need for any additives, and the thus obtained nanodiscs were used to solubilize a membrane protein during cell-free protein synthesis. Given the simplicity of this disc-fabrication method and the ability of these discs to solubilize membrane proteins, this study considerably expands the fundamental and practical scope of graft-copolymer nanodiscs and demonstrates their utility as tools for studying the structure and function of membrane proteins.

    DOI: 10.1039/d2sc01674e

    PubMed

  • Preparation of cationic proteoliposomes using cell-free membrane protein synthesis: the chaperoning effect of cationic liposomes Reviewed

    Mitsuru Ando, Yoshihiro Sasaki, Kazunari Akiyoshi

    RSC ADVANCES   10 ( 48 )   28741 - 28745   2020.08( eISSN:2046-2069

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/d0ra05825d

  • Proteoliposome Engineering with Cell-Free Membrane Protein Synthesis: Control of Membrane Protein Sorting into Liposomes by Chaperoning Systems. Reviewed

    Ando M, Schikula S, Sasaki Y, Akiyoshi K

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)   5 ( 10 )   1800524   2018.10( ISSN:2198-3844

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/advs.201800524

    PubMed

  • Targeted Delivery of Interferon Gamma Using a Recombinant Fusion Protein of a Fibrin Clot-Binding Peptide With Interferon Gamma for Cancer Gene Therapy Reviewed

    Mitsuru Ando, Mai Fujimoto, Yuki Takahashi, Makiya Nishikawa, Atsushi Hamana, Yoshinobu Takakura

    JOURNAL OF PHARMACEUTICAL SCIENCES   106 ( 3 )   892 - 897   2017.03( ISSN:0022-3549 ( eISSN:1520-6017

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1016/j.xphs.2016.11.018

    PubMed

  • Liposome chaperon in cell-free membrane protein synthesis: one-step preparation of KcsA-integrated liposomes and electrophysiological analysis by the planar bilayer method Reviewed

    M. Ando, M. Akiyama, D. Okuno, M. Hirano, T. Ide, S. Sawada, Y. Sasaki, K. Akiyoshi

    BIOMATERIALS SCIENCE   4 ( 2 )   258 - 264   2016( ISSN:2047-4830 ( eISSN:2047-4849

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1039/c5bm00285k

    PubMed

  • Comprehensive study of liposome-assisted synthesis of membrane proteins using a reconstituted cell-free translation system Reviewed

    Tatsuya Niwa, Yoshihiro Sasaki, Eri Uemura, Shugo Nakamura, Minato Akiyama, Mitsuru Ando, Shinichi Sawada, Sada-atu Mukai, Takuya Ueda, Hideki Taguchi, Kazunari Akiyoshi

    SCIENTIFIC REPORTS   5   18025   2015.12( ISSN:2045-2322

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/srep18025

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  • Contribution of epigenetic modifications to the decline in transgene expression from plasmid DNA in mouse liver Reviewed

    Lei Zang, Makiya Nishikawa, Mitsuru Ando, Yuki Takahashi, Yoshinobu Takakura

    Pharmaceutics   7 ( 3 )   199 - 212   2015.08( ISSN:1999-4923

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.3390/pharmaceutics7030199

    PubMed

  • Effects of upregulated indoleamine 2, 3-dioxygenase 1 by interferon gamma gene transfer on interferon gamma-mediated antitumor activity Reviewed

    K. W Watcharanurak, L. Zang, M. Nishikawa, K. Yoshinaga, Y. Yamamoto, Y. Takahashi, M. Ando, K. Saito, Y. Watanabe, Y. Takakura

    GENE THERAPY   21 ( 9 )   794 - 801   2014.09( ISSN:0969-7128 ( eISSN:1476-5462

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/gt.2014.54

  • Enhancement of Anticancer Effect of Interferon-gamma Gene Transfer against Interferon-gamma-Resistant Tumor by Depletion of Tumor-Associated Macrophages Reviewed

    Tsuyoshi Kiyota, Yuki Takahashi, Kanitta Watcharanurak, Makiya Nishikawa, Saori Ohara, Mitsuru Ando, Yoshihiko Watanabe, Yoshinobu Takakura

    MOLECULAR PHARMACEUTICS   11 ( 5 )   1542 - 1549   2014.05( ISSN:1543-8384

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/mp4007216

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  • Long-Term Elimination of Hepatitis C Virus from Human Hepatocyte Chimeric Mice After Interferon-gamma Gene Transfer Reviewed

    Yuki Takahashi, Mitsuru Ando, Makiya Nishikawa, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Yoshinobu Takakura

    HUMAN GENE THERAPY CLINICAL DEVELOPMENT   25 ( 1 )   28 - 39   2014.03( ISSN:2324-8637 ( eISSN:2324-8645

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1089/humc.2013.066

    PubMed

  • Prevention of adverse events of interferon gamma gene therapy by gene delivery of interferon gamma-heparin-binding domain fusion protein in mice Reviewed

    Mitsuru Ando, Yuki Takahashi, Takuma Yamashita, Mai Fujimoto, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura

    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT   1   14023   2014( ISSN:2329-0501

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/mtm.2014.23

    PubMed

  • Expression Profile-Dependent Improvement of Insulin Sensitivity by Gene Delivery of Interleukin-6 in a Mouse Model of Type II Diabetes Reviewed

    Hanae Mukumoto, Yuki Takahashi, Mitsuru Ando, Makiya Nishikawa, Yoshinobu Takakura

    MOLECULAR PHARMACEUTICS   10 ( 10 )   3812 - 3821   2013.10( ISSN:1543-8384 ( eISSN:1543-8392

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1021/mp400288e

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  • Gene Delivery of Albumin Binding Peptide-Interferon-gamma Fusion Protein with Improved Pharmacokinetic Properties and Sustained Biological Activity Reviewed

    Noriko Miyakawa, Makiya Nishikawa, Yuki Takahashi, Mitsuru Ando, Masayuki Misaka, Yoshihiko Watanabe, Yoshinobu Takakura

    JOURNAL OF PHARMACEUTICAL SCIENCES   102 ( 9 )   3110 - 3118   2013.09( ISSN:0022-3549 ( eISSN:1520-6017

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jps.23493

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  • Obstacles and Approaches to the Development of Gene Therapy and Nucleic Acid-based Drug Foreword Reviewed

    Kahori Shimizu, Mitsuru Ando

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   132 ( 12 )   1371 - 1372   2012.12( ISSN:0031-6903 ( eISSN:1347-5231

  • Control of Spatiotemporal Distribution of Interferon gamma by Genetically Fusing Functional Peptides Reviewed

    Mitsuru Ando, Yuki Takahashi, Makiya Nishikawa, Yoshinobu Takakura

    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN   132 ( 12 )   1399 - 1406   2012.12( ISSN:0031-6903 ( eISSN:1347-5231

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  • Constant and steady transgene expression of interferon-gamma by optimization of plasmid construct for safe and effective interferon-gamma gene therapy Reviewed

    Mitsuru Ando, Yuki Takahashi, Makiya Nishikawa, Yoshihiko Watanabe, Yoshinobu Takakura

    JOURNAL OF GENE MEDICINE   14 ( 4 )   288 - 295   2012.04( ISSN:1099-498X

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    Authorship:Lead author   Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jgm.2616

    PubMed

  • Inhibition of nuclear delivery of plasmid DNA and transcription by interferon gamma: hurdles to be overcome for sustained gene therapy Reviewed

    L. Zang, M. Nishikawa, K. Machida, M. Ando, Y. Takahashi, Y. Watanabe, Y. Takakura

    GENE THERAPY   18 ( 9 )   891 - 897   2011.09( ISSN:0969-7128

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1038/gt.2011.35

    PubMed

  • Prolonged Circulation Half-life of Interferon gamma Activity by Gene Delivery of Interferon gamma-Serum Albumin Fusion Protein in Mice Reviewed

    Noriko Miyakawa, Makiya Nishikawa, Yuki Takahashi, Mitsuru Ando, Masayuki Misaka, Yoshihiko Watanabe, Yoshinobu Takakura

    JOURNAL OF PHARMACEUTICAL SCIENCES   100 ( 6 )   2350 - 2357   2011.06( ISSN:0022-3549

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jps.22473

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  • Persistent interferon transgene expression by RNA interference-mediated silencing of interferon receptors Reviewed

    Yuki Takahashi, Elin Vikman, Makiya Nishikawa, Mitsuru Ando, Yoshihiko Watanabe, Yoshinobu Takakura

    JOURNAL OF GENE MEDICINE   12 ( 9 )   739 - 746   2010.09( ISSN:1099-498X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jgm.1493

    PubMed

  • Effect of the content of unmethylated CpG dinucleotides in plasmid DNA on the sustainability of transgene expression Reviewed

    Masaru Mitsui, Makiya Nishikawa, Lei Zang, Mitsuru Ando, Kayoko Hattori, Yuki Takahashi, Yoshihiko Watanabe, Yoshinobu Takakura

    JOURNAL OF GENE MEDICINE   11 ( 5 )   435 - 443   2009.05( ISSN:1099-498X

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    Publishing type:Research paper (scientific journal)  

    DOI: 10.1002/jgm.1317

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MISC

  • DDSナノ粒子の表面修飾材料としての細胞膜

    安藤 満

    細胞   58 ( 1 )   72 - 75   2026.01( ISSN:1346-7557

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    Drug Delivery System(DDS)では,薬剤を必要な部位へ適切に届ける技術が重要である。血球細胞の細胞膜には血中滞留性や標的指向性などDDSに必要な機能が備わっており,膜タンパク質を含む細胞膜をナノ粒子に被覆することで,天然細胞に近い体内動態を付与できる。著者らは内包薬剤を酵素分解依存的に徐放するゼラチンナノ粒子に,血小板や間葉系幹細胞の細胞膜を被覆した細胞膜被覆ゼラチンナノ粒子の開発に取り組んでおり,細胞膜被覆により,膜タンパク質の配向性・機能を保持したままゼラチンナノ粒子の体内動態を改善することに成功している。間葉系幹細胞被覆ゼラチンナノ粒子に薬剤を内包することで,慢性炎症である肝線維症のモデルマウスに対して顕著な治療効果を示した。細胞膜被覆技術は多様なナノ粒子に応用可能であり,炎症制御や再生医療の新たなDDS戦略として期待される。(著者抄録)

  • Plasma membrane as surface modification materials for DDS nanoparticles Invited

    Mitsuru Ando

    58 ( 1 )   72 - 75   2026.01

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    Authorship:Lead author, Corresponding author   Publishing type:Article, review, commentary, editorial, etc. (trade magazine, newspaper, online media)  

  • Is the advanced application of membrane protein as biomaterials just around next corner?

    Ando Mitsuru

    Drug Delivery System   37 ( 1 )   84 - 85   2022.01( ISSN:0913-5006 ( eISSN:1881-2732

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    Authorship:Lead author  

    DOI: 10.2745/dds.37.84

  • Proteo-liposome Engineering: Chaperoning Science for Preparation of Membrane Protein-reconstituted Liposomes

    膜   39 ( 5 )   2014( ISSN:0385-1036

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    Authorship:Lead author  

    J-GLOBAL

Industrial Property Rights

Grant-in-Aid for Scientific Research

  • オルガネラ機能の再構成による細胞オペレーション技術の創出

    挑戦的研究(開拓)  2027

  • オルガネラ機能の再構成による細胞オペレーション技術の創出

    挑戦的研究(開拓)  2026